{"id":106339,"date":"2017-10-16T06:30:46","date_gmt":"2017-10-15T22:30:46","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=106339"},"modified":"2017-10-13T22:43:21","modified_gmt":"2017-10-13T14:43:21","slug":"%e5%94%90%e6%9c%ac%e5%bf%a0%e9%99%a2%e5%a3%abjacs%ef%bc%9a%e7%9a%82%e8%8b%b7%e5%8c%85%e8%a6%86%e5%ae%9e%e7%8e%b0%e8%81%9a%e9%9b%86%e8%af%b1%e5%af%bc%e5%8f%91%e5%85%89%e7%ba%b3%e7%b1%b3%e9%a2%97","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=106339","title":{"rendered":"\u5510\u672c\u5fe0\u9662\u58ebJACS\uff1a\u7682\u82f7\u5305\u8986\u5b9e\u73b0\u805a\u96c6\u8bf1\u5bfc\u53d1\u5149\u7eb3\u7c73\u9897\u7c92\u548c\u6709\u673a\u78f7\u5149\u7eb3\u7c73\u6676\u4f53\u7684\u8d85\u5feb\u9012\u9001"},"content":{"rendered":"

\u3010\u80cc\u666f\u4ecb\u7ecd\u3011<\/strong><\/p>\n

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\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u9999\u6e2f\u79d1\u6280\u5927\u5b66\u5510\u672c\u5fe0\u9662\u58eb\uff08\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u56e2\u961f\u5229\u7528\u7682\u82f7\u72ec\u7279\u7684\u7ec6\u80de\u7a7f\u900f\u6027\u548c\u4e24\u4eb2\u6027\u6027\u8d28\uff0c\u7528\u4e8e\u5305\u8986\u548c\u9012\u9001\u5177\u6709\u6df1\u7ea2\u8272\u805a\u96c6\u8bf1\u5bfc\u53d1\u5149\u7eb3\u7c73\u9897\u7c92\uff08AIE NPs\uff09\u548c\u6709\u673a\u78f7\u5149\u7eb3\u7c73\u6676\u4f53\uff08NCs\uff09\u8fdb\u5165\u7ec6\u80de\u4e2d\u3002\u5b9e\u9a8c\u8868\u660e\u8fd9\u79cd\u65b9\u6cd5\u5177\u6709\u751f\u7269\u76f8\u5bb9\u6027\u597d\uff0c\u6210\u672c\u4f4e\u5ec9\uff0c\u9012\u9001\u8d85\u5feb\u901f\u7b49\u4f18\u5f02\u7684\u7279\u6027\uff0c\u9002\u7528\u4e8e\u5c06\u5404\u79cd\u5404\u6837\u7684AIE NPs\u548cNCs\u9012\u9001\u5230\u764c\u7ec6\u80de\u4e2d\u3002\u76f8\u5173\u6210\u679c\u4ee5\u9898\u4e3a\u201cUltrafast Delivery of Aggregation-Induced Emission Nanoparticles and Pure Organic Phosphorescent Nanocrystals by Saponin Encapsulation<\/strong>\u201d\u53d1\u8868\u5728\u4e86Journal of the American Chemical Society<\/strong>\u4e0a\u3002\u672c\u6587\u7684\u7b2c\u4e00\u4f5c\u8005\u535a\u58eb\u751fAlexander Nicol<\/strong>\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe1 \u5316\u5b66\u7ed3\u6784\u548c<\/strong>\u548c<\/b><\/strong>\u5149\u8c31<\/b><\/strong>\u6027\u80fd<\/b><\/strong><\/p>\n

\"\"<\/p>\n

\uff08A-C\uff09(A) CAPP, (B)TPE-TETRAD \u548c(C) BDBF\u7684\u5316\u5b66\u7ed3\u6784\u548c\u6027\u80fd\uff0cCAPP\u548cTPE-TETRAD\u6df1\u7ea2\u8272\u53d1\u5149AIEgens\uff0cBDBF\u53ef\u4ee5\u5f62\u6210\u6709\u673a\u78f7\u5149\u7eb3\u7c73\u6676\u4f53\uff0c\u5b83\u4eec\u90fd\u662f\u7ec6\u80de\u819c\u4e0d\u6e17\u900f\u7684\u3002<\/p>\n

\u56fe2 <\/strong>\u7682\u82f7\u5305\u8986\u540e\u7684\u7eb3\u7c73\u6750\u6599<\/b><\/strong>\u7c92\u5ea6\u5206\u5e03\u53ca\u52a8\u6001\u5149\u6563\u5c04\u5206\u6790\uff08DLS\uff09<\/b><\/strong><\/p>\n

\"\"<\/p>\n

\uff08A\uff09\u7682\u82f7\u5305\u8986\u7684CAPP\u7eb3\u7c73\u9897\u7c92\u7684\u7c92\u5ea6\u5206\u5e03<\/p>\n

\uff08B\uff09\u7682\u82f7\u5305\u8986\u7684TPE-TETRAD \u7eb3\u7c73\u9897\u7c92\u7684\u7c92\u5ea6\u5206\u5e03\u3002\u63d2\u5165\u7684\u56fe\u7247\u4e3a\u7535\u955c\u56fe\u3002<\/p>\n

\u56fe3 CLSM\u56fe\u50cf<\/strong><\/p>\n

\"\"<\/p>\n

\uff08A-F\uff09\u75280.5\u03bcg\/ mL\u7684\u7682\u82f7\u5305\u8986\u7684TPE-TETRAD \u7eb3\u7c73\u9897\u7c92\u5206\u522b\u57f9\u80b2\uff08A\uff0930\u79d2\uff0c\uff08B\uff092\u5206\u949f\uff0c\uff08C\uff093\u5206\u949f\uff0c\uff08D\uff095\u5206\u949f\uff0c\uff08E\uff0910\u5206\u949f\u548c\uff08F\uff0930\u5206\u949f\u540e\u7684HeLa\u5bab\u9888\u764c\u7ec6\u80de\u7684CLSM\u56fe\u50cf<\/p>\n

\u56fe4 \u6709\u6548\u67d3\u8272\u65f6\u95f4\u5bf9\u6bd4<\/strong><\/p>\n

\"\"<\/p>\n

\u7ec6\u80de\u53ef\u6e17\u900f\u7684AIEgens\uff0c\u5546\u4e1a\u8367\u5149\u67d3\u6599\u548c\u5404\u79cdAIE NPs\u9012\u9001\u65b9\u6cd5\u4e4b\u95f4\u7684\u6709\u6548\u67d3\u8272\u65f6\u95f4\u6bd4\u8f83\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

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\u6587\u732e\u94fe\u63a5\uff1a<\/strong>Ultrafast Delivery of Aggregation-Induced Emission Nanoparticles and Pure Organic Phosphorescent Nanocrystals by Saponin Encapsulation<\/a>\uff08JACS, 2017, DOI:10.1021\/jacs.7b08710\uff09<\/p>\n

\u56e2\u961f\u4ecb\u7ecd<\/strong><\/p>\n

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\u56e2\u961f\u5728\u8be5\u9886\u57df\u5de5\u4f5c\u6c47\u603b<\/strong><\/p>\n

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\u8be6\u60c5\u8bbf\u95ee\u5510\u672c\u5fe0\u9662\u58eb\u56e2\u961f\u7f51\u7ad9\uff1ahttp:\/\/webhost1.ust.hk\/~tangbz\/<\/a><\/p>\n

\u76f8\u5173\u4f18\u8d28\u6587\u732e\u63a8\u8350<\/strong><\/p>\n

    \n
  1. Ju Mei; Nelson L. C. Leung; Ryan T. K. Kwok; Jacky W. Y. Lam; Ben Zhong Tang*, Aggregation-Induced Emission: Together We Shine, United We Soar! Chem. Rev.<\/i><\/em>2015<\/b><\/strong>, 115<\/i><\/em>, 11718-11940.<\/li>\n
  2. Ryan T. K. Kwok; Chris W. T. Leung; Jacky W. Y. Lam; Ben Zhong Tang*, Biosensing by luminogens with aggregation-induced emission characteristics. Chem. Soc. Rev.<\/i><\/em>2015<\/b><\/strong>, 44<\/i><\/em>, 4228-4238.<\/li>\n
  3. Xinggui Gu, Engui Zhao, Jacky W. Y. Lam, Qian Peng, Yujun Xie, Yilin Zhang, Kam Sing Wong, Herman H. Y. Sung, Ian D. Williams, Ben Zhong Tang*, Mitochondrion-Specific Live-Cell Bioprobe Operated in a Fluorescence Turn-On Manner and a Well-Designed Photoactivatable Mechanism. Adv. Mater.<\/i><\/em>2015<\/b><\/strong>, 27(44)<\/i><\/em>, 7093-7100.<\/li>\n
  4. Xinggui Gu, Engui Zhao, Teng Zhao, Miaomiao Kang, Chen Gui, Jacky W. Y. Lam, Shengwang Du, Michael M. T. Loy and Ben Zhong Tang*, A Mitochondrion-Specific Photoactivatable Fluorescence Turn-On AIE-Based Bioprobe for Localization Super-Resolution Microscope. Adv. Mater.<\/i><\/em>2016<\/b><\/strong>, 28<\/i><\/em>, 5064-5071.<\/li>\n
  5. Zhegang Song, Duo Mao, Simon H. P. Sung, Ryan T. K. Kwok, Jacky W. Y. Lam, Deling Kong, Dan Ding* and Ben Zhong Tang*, Activatable Fluorescent Nanoprobe with Aggregation-Induced Emission Characteristics for Selective In Vivo Imaging of Elevated Peroxynitrite Generation. Adv. Mater.<\/i><\/em>2016<\/b><\/strong>, 28<\/i><\/em>, 7249-7256.<\/li>\n
  6. Chris Y. Y. Yu, Huae Xu, Shenglu Ji, Ryan T. K. Kwok, Jacky W. Y. Lam, Xiaolin Li*, Sunil Krishnan, Dan Ding*, Ben Zhong Tang*, Mitochondrion-Anchoring Photosensitizer with Aggregation-Induced Emission Characteristics Synergistically Boosts the Radiosensitivity of Cancer Cells to Ionizing Radiation. Adv. Mater<\/i><\/em>. 2017<\/b><\/strong>, 29, <\/i><\/em>1606167.<\/li>\n
  7. Wang Zhang Yuan, Yeqiang Tan, Yongyang Gong, Ping Lu, Jacky W. Y. Lam, Xiao Yuan Shen, Cunfang Feng, Herman H-Y. Sung, Yawei Lu, Ian D. Williams, Jing Zhi Sun, Yongming Zhang*, Ben Zhong Tang*, Synergy between Twisted Conformation and Effective Intermolecular Interactions: Strategy for Efficient Mechanochromic Luminogens with High Contrast. Adv. Mater.<\/i><\/em>2013<\/b><\/strong>, 25<\/i><\/em>, 2837-2843.<\/li>\n
  8. Sijie Chen, Yuning Hong,Yang Liu, Jianzhao Liu, Chris W. T. Leung, Min Li, Ryan T. K. Kwok, Engui Zhao, Jacky W. Y. Lam, Yong Yu, Ben Zhong Tang*, Full-Range Intracellular pH Sensing by an Aggregation-Emission-Active Two-Channel Ratiometric Fluorogen. J. Am. Chem. Soc.<\/i><\/em>2013<\/b><\/strong>, 135<\/i><\/em>, 4926-4929.<\/li>\n
  9. Zhengke Wang, Sijie Chen, Jacky W. Y. Lam, Wei Qin, Ryan T. K. Kwok, Ni Xie, Qiaoling Hu, Ben Zhong Tang*, Long-Term Fluorescent Cellular Tracing by the Aggregates of AIE Bioconjugates. J. Am. Chem. Soc.<\/i><\/em>2013<\/b><\/strong>,135<\/i><\/em>, 8238-8245.<\/li>\n
  10. Hui-Qing Peng, Xiaoyan Zheng, Ting Han, Ryan T. K. Kwok, Jacky W. Y. Lam, Xuhui Huang, Ben Zhong Tang*, Dramatic Differences in Aggregation-Induced Emission and Supramolecular Polymerizability of Tetraphenylethene-Based Stereoisomers. J. Am. Chem. Soc.<\/i><\/em>2017<\/b><\/strong>, 139 (29),<\/i><\/em>10150-10156.<\/li>\n<\/ol>\n

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