{"id":120245,"date":"2018-01-07T14:00:54","date_gmt":"2018-01-07T06:00:54","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=120245"},"modified":"2018-01-05T21:19:58","modified_gmt":"2018-01-05T13:19:58","slug":"adv-mater%ef%bc%9a%e7%94%9f%e7%89%a9%e5%8f%af%e9%99%8d%e8%a7%a3%e7%9a%84%e5%85%89%e5%93%8d%e5%ba%94%e7%ba%b3%e7%b1%b3%e6%91%87%e9%93%83%e5%ae%9e%e7%8e%b0%e7%99%8c%e7%97%87%e8%af%8a","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=120245","title":{"rendered":"Adv. Mater\uff1a\u751f\u7269\u53ef\u964d\u89e3\u7684\u5149\u54cd\u5e94\u201c\u7eb3\u7c73\u6447\u94c3\u201d\u5b9e\u73b0\u764c\u75c7\u8bca\u7597\u4e00\u4f53\u5316"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/strong>
\n \u5c06\u8bca\u65ad\u548c\u7cbe\u51c6\u6cbb\u7597\u76f8\u7ed3\u5408\u7684\u591a\u529f\u80fd\u7eb3\u7c73\u5e73\u53f0\u7528\u4e8e\u764c\u75c7\u7684\u8bca\u65ad\u4e0e\u6cbb\u7597\uff0c\u5728\u7eb3\u7c73\u751f\u7269\u6280\u672f\u65b9\u9762\u8868\u73b0\u51fa\u5de8\u5927\u7684\u6f5c\u529b\u3002\u5728\u4e0d\u540c\u7684\u751f\u7269\u6210\u50cf\u6280\u672f\u4e2d\uff0c\u8d85\u58f0\u6210\u50cf\u56e0\u5177\u6709\u5b9e\u65f6\u6210\u50cf\u3001\u5bf9\u7ec4\u7ec7\u65e0\u635f\u4f24\u3001\u82b1\u8d39\u4f4e\u7b49\u4f18\u70b9\uff0c\u6210\u4e3a\u4e34\u5e8a\u4e0a\u666e\u904d\u5e94\u7528\u7684\u8bca\u65ad\u6280\u672f\u3002\u88c5\u8f7d\u5404\u79cd\u6cbb\u7597\u5242\u7684\u5fae\u6ce1\u5219\u88ab\u5e7f\u6cdb\u7528\u4f5c\u8d85\u58f0\u9020\u5f71\u5242\uff08UCAs\uff09\u3002\u901a\u5e38\u6765\u8bf4\u8d85\u58f0\u9020\u5f71\u5242\u662f\u7531\u60f0\u6027\u7684\u5168\u6c1f\u5316\u78b3\u6c14\u4f53\u548c\u805a\u5408\u7269\u6216\u86cb\u767d\u8d28\u7ec4\u5408\u800c\u6210\uff0c\u4f46\u662f\u60f0\u6027\u6c14\u4f53\u5728\u4f53\u6e29\u7684\u73af\u5883\u4e0b\u4f1a\u53d1\u751f\u81a8\u80c0\u800c\u4ece\u677e\u6563\u7684\u5916\u58f3\u4e2d\u6269\u6563\u51fa\u6765\uff0c\u56e0\u800c\u534a\u8870\u671f\u5f88\u77ed\uff08<20 min\uff09\uff1b\u53e6\u5916\uff0c\u5fae\u6ce1\u7684\u76f4\u5f84\u8f83\u5927\uff08\u901a\u5e38\u4e3a1-8 \u03bcm\uff09\uff0c\u8fdb\u4e00\u6b65\u963b\u788d\u4e86\u9020\u5f71\u5242\u5728\u975e\u5fae\u7c73\u8840\u7ba1\u7ec4\u7ec7\u5468\u56f4\u7684\u6e17\u900f\u3002\u56e0\u6b64\uff0c\u63d0\u9ad8\u8d85\u58f0\u9020\u5f71\u5242\u7684\u7a33\u5b9a\u6027\u548c\u80bf\u7624\u7a7f\u900f\u6027\u5bf9\u7814\u7a76\u8005\u6765\u8bf4\u4ecd\u7136\u662f\u91cd\u5927\u7684\u6311\u6218\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong>
\n \u8fd1\u65e5\uff0c\u6df1\u5733\u5927\u5b66\u9ec4\u9e4f\u6559\u6388\u548c\u6e29\u5dde\u5927\u5b66\u6768\u4e91\u7814\u7a76\u5458\uff08\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u56e2\u961f\u5728Advanced Materials<\/strong>\u5728\u7ebf\u53d1\u8868\u4e86\u4e00\u7bc7\u9898\u4e3a\u201cLight-Responsive Biodegradable Nanorattles for Cancer Theranostics<\/strong>\u201d\u7684\u6587\u7ae0\uff0c\u4ecb\u7ecd\u4e86\u4e00\u79cd\u751f\u7269\u53ef\u964d\u89e3\u7684\u5149\u54cd\u5e94\u7eb3\u7c73\u6447\u94c3\uff0c\u53ef\u4ee5\u5728\u6fc0\u5149\u6fc0\u53d1\u4e0b\u5229\u7528\u8d85\u58f0\/\u5149\u58f0\u53cc\u6a21\u6001\u6210\u50cf\u5bf9\u764c\u75c7\u8fdb\u884c\u8bca\u65ad\uff0c\u540c\u65f6\u5b9e\u73b0\u764c\u75c7\u5149\u70ed\u6cbb\u7597\u3002\u8be5\u7814\u7a76\u6700\u5927\u7684\u521b\u65b0\u70b9\u5728\u4e8e\u7814\u7a76\u8005\u5c06\u91d1\u7eb3\u7c73\u68d2\uff08GNR\uff09\u4e0e\u5168\u6c1f\u620a\u70f7\uff08PFP\uff09\u540c\u65f6\u8d1f\u8f7d\u5230\u4ecb\u5b54\u4e8c\u6c27\u5316\u7845\u4e2d\uff0c\u5f97\u5230\u5149\u54cd\u5e94\u7eb3\u7c73\u6447\u94c3\uff1aGNR@SiO2-PFP\uff0c\u5229\u7528GNR\u7684\u5149\u70ed\u6548\u5e94\u6fc0\u53d1PFP\u4ea7\u751f\u5fae\u6ce1\u5f97\u5230\u9ad8\u8d28\u91cf\u7684\u56fe\u50cf\uff0c\u540c\u65f6\u5b9e\u73b0\u5bf9\u764c\u75c7\u7684\u5149\u70ed\u6cbb\u7597\u4f5c\u7528\uff1b\u53e6\u5916\uff0c\u5229\u7528\u4ecb\u5b54\u4e8c\u6c27\u5316\u7845\u4f5c\u4e3a\u8f7d\u4f53\uff0c\u4e0d\u4ec5\u53ef\u4ee5\u5ef6\u957f\u5176\u8840\u6db2\u5faa\u73af\u65f6\u95f4\uff0c\u800c\u4e14\u53ef\u751f\u7269\u964d\u89e3\u964d\u4f4e\u4f53\u5185\u6bd2\u6027\u3002\u8fd9\u4e00\u6750\u6599\u7684\u53d1\u660e\u4e3a\u540e\u7eed\u764c\u75c7\u7684\u8bca\u65ad\u4e0e\u6cbb\u7597\u7814\u7a76\u63d0\u4f9b\u4e86\u65b0\u7684\u65b9\u5411\u548c\u601d\u8def\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe1. GNR@SiO2-PFP\u7eb3\u7c73\u6447\u94c3\u7684\u8868\u5f81<\/strong><\/p>\n

\"\"<\/p>\n

a\uff09 GNR@ZnO\u7684TEM\u8868\u5f81\u3002<\/p>\n

b\uff09 GNR@SiO2\u7684TEM\u8868\u5f81\u3002<\/p>\n

c\uff09 GNR@SiO2\u7684SEM\u8868\u5f81\u3002<\/p>\n

d\uff09 GNR\u3001GNR@ZnO\u548cGNR@SiO2\u6eb6\u6db2\u7167\u7247\u3002<\/p>\n

e\uff09 GNR\u548cGNR@SiO2 \u7684UV-vis-NIR\u5149\u8c31\u3002<\/p>\n

f\uff09 pH7.4\u73af\u5883\u4e0bGNR\u548cGNR@SiO2 \u7684Zeta\u7535\u4f4d\u3002<\/p>\n

\u56fe2. GNR@SiO2-PFP\u5728\u4f53\u5916\u4ea7\u751f\u5fae\u6ce1\u8fc7\u7a0b\u8868\u5f81<\/strong><\/p>\n

\"\"<\/p>\n

a\uff09 808 nm\uff0c1 W\/cm2\uff0c5 min\u6761\u4ef6\u4e0bPBS\u548c\u4e0d\u540c\u6d53\u5ea6\u7684GNR@SiO2\u6eb6\u6db2\uff085,10,20,40,80 ppm of Au\uff09\u7684\u5347\u6e29\u66f2\u7ebf\u3002<\/p>\n

b\uff09 PFP\u7684GC-MS\u8272\u8c31\u56fe\u3002<\/p>\n

c\uff09 42 \u2103\u52a0\u70ed2 min\u540e\u6c14\u6ce1\u4ea7\u751f\u60c5\u51b5\u3002<\/p>\n

d-e) \u6fc0\u5149\u7167\u5c04\u524d\u540eGNR@SiO2-PFP\u4ea7\u751f\u6c14\u6ce1\u7684\u7167\u7247\uff08808 nm\uff0c1 W\/cm2\uff0c5 min\uff09\u3002<\/p>\n

f-g) GNR@SiO2-PFP\u5b75\u80b2\u540e\u6fc0\u5149\u7167\u5c04\u4e0bA375\u7ec6\u80de\u5185\u4ea7\u751f\u6c14\u6ce1\u7684\u7167\u7247\uff08808 nm\uff0c1 W\/cm2\uff0c5 min\uff09\u3002<\/p>\n

\u56fe3. \u5b75\u80b2GNR@SiO2-PFP\u540eA375\u7ec6\u80de\u7684\u751f\u7269\u7535\u955c\u8868\u5f81<\/strong><\/p>\n

\"\"<\/p>\n

a-b) GNR@SiO2-PFP\u5b75\u80b22\u5c0f\u65f6\u540eA375\u7ec6\u80de\u7684bio-TEM\u8868\u5f81\u3002<\/p>\n

c-d) GNR@SiO2-PFP\u5b75\u80b25\u5c0f\u65f6\u540eA375\u7ec6\u80de\u7684bio-TEM\u8868\u5f81\u3002<\/p>\n

e-f) GNR@SiO2-PFP\u5b75\u80b224\u5c0f\u65f6\u540eA375\u7ec6\u80de\u7684bio-TEM\u8868\u5f81\u3002<\/p>\n

\u56fe4. \u4f53\u5916\u7ec6\u80de\u5b9e\u9a8c<\/strong><\/p>\n

\"\"<\/p>\n

a\uff09 A375\u7ec6\u80de\u5206\u522b\u5b75\u80b2\u4e0d\u540c\u6d53\u5ea6\uff080-100 ppm\uff09GNR@SiO2\u548cGNR@SiO2-PFP\u7eb3\u7c73\u7c92\u5b5024\u5c0f\u65f6\u540e\u7684\u7ec6\u80de\u6bd2\u6027\u5b9e\u9a8c\u3002<\/p>\n

b\uff09 A375\u7ec6\u80de\u5b75\u80b2GNR@SiO224\u5c0f\u65f6\u540e\u6fc0\u5149\u7167\u5c04\uff08808 nm\uff0c1 W\/cm2\uff09\u4e0d\u540c\u65f6\u95f4\u7684\u7ec6\u80de\u6d3b\u6027\u5b9e\u9a8c\uff08**P<0.01\uff0c***P<0.001\uff09\u3002<\/p>\n

c\uff09 \u4e0d\u540c\u5904\u7406\u65b9\u5f0f\u5904\u7406A375\u540e\u6b7b\/\u6d3b\u7ec6\u80de\u53cc\u67d3\u7ed3\u679c\uff08calcein AM\uff1a\u6d3b\u7ec6\u80de\uff0c\u7eff\u8272\u8367\u5149\uff1bPI\uff1a\u6b7b\u7ec6\u80de\uff0c\u7ea2\u8272\u8367\u5149\uff1bGNR@SiO2\u5185Au\u542b\u91cf\uff1a25 ppm\uff1b808 nm\uff0c1 W\/cm2\uff0c5 min\uff09\u3002<\/p>\n

\u56fe5. \u8d85\u58f0\u548c\u5149\u58f0\uff08US\/PA\uff09\u6210\u50cf<\/strong><\/p>\n

\"\"<\/p>\n

a\uff09 GNR@SiO2-PFP\u6eb6\u6db2\u52a0\u70ed\u524d\u540e\u4ee5\u53ca\u6fc0\u5149\u7167\u5c04\u540e\u4f53\u5916\u8d85\u58f0\u6210\u50cf\u56fe\uff08Au\uff1a10 ppm\uff09\u3002<\/p>\n

b\uff09 GNR@SiO2-PFP\u6eb6\u6db2\u52a0\u70ed\u524d\u540e\u4ee5\u53ca\u6fc0\u5149\u7167\u5c04\u540e\u4f53\u5916\u8d85\u58f0\u6210\u50cf\u56fe\u5bf9\u5e94\u7684\u7070\u5ea6\u503c\uff08Au\uff1a10 ppm\uff09\u3002c\uff09 \u4e0d\u540c\u6d53\u5ea6\u4e0bGNR@SiO2-PFP\u6eb6\u6db2\u7684\u4f53\u5916\u5149\u58f0\u6210\u50cf\u56fe\uff08OD\uff1a0.25-1.5\uff09\u3002<\/p>\n

d\uff09 GNR@SiO2-PFP\u6ce8\u5c04\u524d\u540e\u53ca\u6fc0\u5149\u7167\u5c04\u524d\u540e\u7684\u4f53\u5185\u8d85\u58f0\u6210\u50cf\u56fe\u3002<\/p>\n

e\uff09 GNR@SiO2-PFP\u6ce8\u5c04\u524d\u540e\u53ca\u6fc0\u5149\u7167\u5c04\u524d\u540e\u80bf\u7624\u7ec4\u7ec7\u7684\u8d85\u58f0\u4fe1\u53f7\u7070\u5ea6\u503c\u3002<\/p>\n

f\uff09 GNR@SiO2-PFP\u6ce8\u5c04\u524d\u4ee5\u53ca\u6ce8\u5c04\u540e\u4e0d\u540c\u65f6\u95f4\u70b9\u7684\u5149\u58f0\u6210\u50cf\u56fe\u3002<\/p>\n

g\uff09 GNR@SiO2-PFP\u6ce8\u5c04\u524d\u4ee5\u53ca\u6ce8\u5c04\u540e\u4e0d\u540c\u65f6\u95f4\u70b9\u7684\u5149\u58f0\u4fe1\u53f7\u503c\u3002<\/p>\n

\u56fe6. GNR@SiO2-PFP\u5bf9A375\u80bf\u7624\u8001\u9f20\u4f53\u5185\u6cbb\u7597\u6548\u679c\u8bc4\u4ef7<\/strong><\/p>\n

\"\"<\/p>\n

a\uff09 PBS\u548cGNR@SiO2-PFP\u6ce8\u5c0424\u5c0f\u65f6\u540e\u6fc0\u5149\u7167\u5c04\u8001\u9f20\u7684\u70ed\u6210\u50cf\u793a\u610f\u56fe\u3002<\/p>\n

b\uff09 PBS\u548cGNR@SiO2-PFP\u6ce8\u5c0424\u5c0f\u65f6\u540e\u6fc0\u5149\u7167\u5c04\u8001\u9f20\u7684\u6e29\u5ea6\u53d8\u5316\u3002<\/p>\n

c\uff09 \u80bf\u7624\u4f53\u79ef\u7684\u76f8\u5bf9\u751f\u957f\u66f2\u7ebf\u3002<\/p>\n

d\uff09 \u4e0d\u540c\u5904\u7406\u65b9\u5f0f\u5904\u740618\u5929\u540e\u80bf\u7624\u8d28\u91cf\u3002<\/p>\n

e\uff09 \u4e0d\u540c\u5904\u7406\u7ec4\u8001\u9f20\u7684\u7167\u7247\u3002<\/p>\n

f\uff09 \u4e0d\u540c\u5904\u7406\u7ec4\u8001\u9f20\u80bf\u7624\u5207\u7247\u7684H&E\u8868\u5f81\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong>
\n GNR@SiO2-PFP\u7eb3\u7c73\u6447\u94c3\u901a\u8fc7\u5149\u54cd\u5e94\u53ef\u4ee5\u91ca\u653e\u5fae\u6ce1\u4f7f\u8d85\u58f0\u6210\u50cf\u8d28\u91cf\u63d0\u9ad8\uff0c\u540c\u65f6\u5fae\u6ce1\u53ef\u4ee5\u7a7f\u900f\u975e\u5fae\u8840\u7ba1\uff0c\u589e\u52a0\u80bf\u7624\u90e8\u4f4d\u6750\u6599\u7684\u5bcc\u96c6\uff1b\u800c\u4e14\u53ef\u5728US\/PA\u53cc\u6a21\u6001\u6210\u50cf\u7684\u4ecb\u5bfc\u4e0b\u5bf9\u9ed1\u8272\u7d20\u7624\u8fdb\u884c\u5149\u70ed\u6cbb\u7597\u3002\u8fd9\u4e00\u7eb3\u7c73\u6447\u94c3\u7684\u53d1\u660e\u5b9e\u73b0\u4e86\u764c\u75c7\u7684\u8bca\u7597\u4e00\u4f53\u5316\uff0c\u968f\u7740\u7eb3\u7c73\u533b\u5b66\u7684\u53d1\u5c55\uff0c\u8be5\u7814\u7a76\u4e3a\u764c\u75c7\u7684\u8bca\u65ad\u4e0e\u6cbb\u7597\u63d0\u4f9b\u4e86\u65b0\u7684\u7814\u7a76\u601d\u8def\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1a<\/strong>Light-Responsive Biodegradable Nanorattles for Cancer Theranostics<\/a>\uff08Advanced. Materials.\uff0c2017\uff0cDOI: 10.1002\/adma.201706150\uff09<\/p>\n

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