{"id":126379,"date":"2018-02-23T14:00:11","date_gmt":"2018-02-23T06:00:11","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=126379"},"modified":"2018-02-19T14:48:32","modified_gmt":"2018-02-19T06:48:32","slug":"%e6%b7%b1%e5%9c%b3%e5%a4%a7%e5%ad%a6adv-mater-%ef%bc%9a89zr%e6%a0%87%e8%ae%b0%e7%9a%84%e7%99%8c%e7%97%87%e7%bb%86%e8%83%9e%e8%86%9c%e9%87%8d%e7%bb%84%e8%a3%85%e5%bd%a2%e6%88%90%e7%9a%84%e5%a4%9a","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=126379","title":{"rendered":"\u6df1\u5733\u5927\u5b66Adv. Mater.\uff1a89Zr\u6807\u8bb0\u7684\u764c\u75c7\u7ec6\u80de\u819c\u91cd\u7ec4\u88c5\u5f62\u6210\u7684\u591a\u5ba4\u8102\u8d28\u4f53\u5728PET\u793a\u8e2a\u548c\u764c\u75c7\u9776\u5411\u8bca\u7597\u4e2d\u7684\u5e94\u7528"},"content":{"rendered":"

\u3010\u5f15\u8a00<\/b><\/strong>\u3011<\/p>\n

\u7ec6\u80de\u819c\u62e5\u6709\u6781\u597d\u7684\u751f\u7269\u76f8\u5bb9\u6027\u3001\u9003\u8131\u514d\u75ab\u7cfb\u7edf\u548c\u7f51\u72b6\u5185\u76ae\u7cfb\u7edf\u7684\u80fd\u529b\uff0c\u56e0\u6b64\u88ab\u8ba4\u4e3a\u5728\u764c\u75c7\u7684\u9776\u5411\u8bca\u7597\u4e2d\u6709\u5f88\u597d\u7684\u6f5c\u529b\u3002\u76ee\u524d\uff0c\u57fa\u4e8e\u751f\u7269\u7ec6\u80de\u819c\u7684\u764c\u75c7\u8bca\u7597\u7814\u7a76\u5df2\u53d6\u5f97\u4e86\u4e00\u4e9b\u7a81\u7834\u6027\u7684\u8fdb\u5c55\uff0c\u8fd9\u4e9b\u7814\u7a76\u4e3b\u8981\u4ee5\u5149\u5b66\u6210\u50cf\u4e3a\u8f85\u52a9\u3002\u7531\u4e8e\u5149\u5b66\u6210\u50cf\u7684\u7a7f\u900f\u6df1\u5ea6\u9650\u5236\u548c\u4e0d\u80fd\u5b9a\u91cf\u7684\u7279\u70b9\uff0c\u8fd9\u4e9b\u524d\u671f\u7684\u7814\u7a76\u5de5\u4f5c\u5728\u836f\u7269\u4ee3\u8c22\u52a8\u529b\u5b66\u4e0a\u7684\u95ee\u9898\u4e0a\u5f88\u96be\u89e3\u91ca\u3002\u800c\u57fa\u4e8e\u751f\u7269\u7ec6\u80de\u819c\u7684\u764c\u75c7\u8bca\u7597\u7cfb\u7edf\u7684\u836f\u7269\u4ee3\u8c22\u52a8\u529b\u5b66\u7814\u7a76\u53ef\u4ee5\u5e2e\u52a9\u79d1\u7814\u5de5\u4f5c\u8005\u66f4\u597d\u5730\u8bbe\u8ba1\u548c\u6539\u8fdb\u8bca\u7597\u7cfb\u7edf\uff0c\u56e0\u6b64\u5f00\u53d1\u53ef\u5b9a\u91cf\u3001\u7cbe\u51c6\u548c\u53ef\u957f\u671f\u6210\u50cf\u7684\u751f\u7269\u819c\u7eb3\u7c73\u7c92\u5b50\uff0c\u6765\u5b9e\u73b0\u8bca\u7597\u8fc7\u7a0b\u4e2d\u7684\u5206\u5e03\u548c\u4ee3\u8c22\u793a\u8e2a\u5c31\u663e\u5f97\u5341\u5206\u5fc5\u8981\u4e86\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb<\/b><\/strong>\u3011<\/p>\n

\u8fd1\u65e5\uff0c\u6df1\u5733\u5927\u5b66<\/b><\/strong>\u533b\u5b66\u90e8\u7684\u4f55\u524d\u519b\u6559\u6388<\/b><\/strong>\u548c\u5149\u7535\u5b66\u9662\u7684\u5f20\u6657\u6559\u6388<\/b><\/strong>\uff0c\u4e0e\u7f8e\u56fd\u5a01\u65af\u5eb7\u661f\u5927\u5b66\u9ea6\u8fea\u900a\u5206\u6821<\/b><\/strong>\u7684\u8521\u4f1f\u6ce2<\/b><\/strong>\u6559\u6388<\/b><\/strong>\u8bfe\u9898\u7ec4\u5408\u4f5c\uff0c\u8054\u5408\u5f00\u53d1\u4e86\u4e00\u79cd89<\/sup>Zr\u6807\u8bb0\u7684\u764c\u7ec6\u80de\u819c\u91cd\u7ec4\u88c5\u5f62\u6210\u7684\u591a\u5ba4\u8102\u8d28\u4f53\uff0c\u5e76\u5728PET\u793a\u8e2a\u548c\u764c\u75c7\u9776\u5411\u8bca\u7597\u4e2d\u53d6\u5f97\u4e86\u5f88\u597d\u7684\u6548\u679c\u3002\u5728\u8fd9\u4e2a\u5de5\u4f5c\u4e2d\uff0c\u4f5c\u8005\u5c06Tween-80\u5f15\u5165\u764c\u7ec6\u80de\u819c\uff0c\u5408\u6210\u4e86\u4e00\u79cd\u65b0\u578b\u7684\u591a\u5ba4\u8102\u8d28\u4f53(MCLs)\u3002\u56db\u7fa7\u57fa\u82ef\u57fa\u535f\u5549(TCPP)\u4f5c\u4e3a\u8367\u5149\u6307\u793a\u5242\u548c\u5149\u52a8\u529b\u5b66\u6cbb\u7597\u7684\u5149\u654f\u5242\u88ab\u5f15\u5165MCLs\u3002MCLs\u53c8\u901a\u8fc7\u87af\u5408\u5242p-SCN-deferoxamine\u4e3a\u6865\u8fde\uff0c\u8fde\u63a589<\/sup>Zr\uff0c\u5f62\u6210\u6700\u7ec8\u7684\u7eb3\u7c73\u7ed3\u6784\uff0c89<\/sup>Zr-Df-MCL\u3002\u5728\u540e\u7eed\u7684\u52a8\u7269\u5b9e\u9a8c\u4e2d\uff0c89<\/sup>Zr-Df-MCL\u8868\u73b0\u51fa\u4e86\u5353\u8d8a\u7684\u653e\u5c04\u5316\u5b66\u7a33\u5b9a\u6027\u3001\u66f4\u597d\u7684\u80bf\u7624\u6e17\u900f\u6027\u548c\u6ede\u7559\u6548\u679c\uff1b\u5728\u4fdd\u6301\u957f\u671f\u4e14\u6709\u6548\u7684\u5149\u52a8\u529b\u5b66\u6cbb\u7597\u6548\u679c\u540c\u65f6\uff0c\u4e5f\u80fd\u901a\u8fc7\u809d\u810f\u6392\u6cc4\u4ece\u4f53\u5185\u6e05\u9664\u3002\u8fd9\u79cdMCLs\u6784\u5efa\u65b9\u6cd5\u4e5f\u4e3a\u5176\u4ed6\u764c\u75c7\u7684\u6cbb\u7597\u63d0\u4f9b\u4e86\u65b0\u7684\u601d\u8def\u3002\u8be5\u6210\u679c\u4ee5\u9898\u4e3a”Reassembly of <\/b><\/strong>89<\/b><\/sup><\/strong>Zr-labeled Cancer Cell Membranes into Multicompartment Membrane-Derived Liposomes for PET-Trackable Tumor-Targeted Theranostics<\/b><\/strong>“\u53d1\u8868\u5728Adv. Mater.<\/b><\/strong>\u4e0a\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb<\/b><\/strong>\u3011<\/p>\n

\u56fe<\/b><\/strong>1 MCLs<\/b><\/strong>\u7684\u5236\u5907\u8fc7\u7a0b\u548c<\/b><\/strong>89<\/b><\/sup><\/strong>Zr<\/b><\/strong>\u6807\u8bb0<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(A)MCL\u5236\u5907\u793a\u610f\u56fe<\/p>\n

(B)Tween-80\u80f6\u675f\u3001\u7ec6\u80de\u819c\u7eb3\u7c73\u56ca\u6ce1\uff08CMVs\uff09\u548cMCLs\u7684\u7c92\u5f84<\/p>\n

(C,D)CMVs\u548cMCLs\u7684TEM\u56fe<\/p>\n

(E)89<\/sup>Zr\u5728\u4e0d\u540c\u65f6\u95f4\u5bf9Df-MCLs\u7684\u6807\u8bb0\u6548\u7387<\/p>\n

(F)89<\/sup>Zr-Df-MCLs\u5bf9\u5e94\u4e0d\u540c\u65f6\u95f4\u7684\u8584\u5c42\u8272\u8c31\u653e\u5c04\u81ea\u663e\u5f71\u56fe<\/p>\n

(G)89<\/sup>Zr-Df-MCLs\u7684\u8840\u6e05\u7a33\u5b9a\u6027<\/p>\n

\u56fe<\/b><\/strong>2<\/b><\/strong>\u00a0<\/b><\/strong>89<\/b><\/sup><\/strong>Zr-Df-MCLs<\/b><\/strong>\u7684\u751f\u7269\u4f53\u5206\u5e03\u548c\u809d\u810f\u6392\u6cc4<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(A)89<\/sup>Zr-Df-MCLs\u9759\u8109\u6ce8\u5c04\u5c0f\u9f20\u4f53\u5185PET\u6210\u50cf(0.5, 1, 2, 5, 12, 24, 48\u548c72\u5c0f\u65f6)<\/p>\n

(B)\u5728\u4e0d\u540c\u65f6\u95f4\u70b9\uff0c\u809d\u810f\u901a\u8fc7\u7caa\u4fbf\u6e05\u966489<\/sup>Zr-Df-MCLs<\/p>\n

(C)\u4e0d\u540c\u65f6\u95f4\u70b9\u7caa\u4fbf\u7684PET\u6210\u50cf<\/p>\n

(D)1h\u4e3b\u8981\u5668\u5b98\u7684PET\u6210\u50cf<\/p>\n

(E)24h\u4e3b\u8981\u5668\u5b98\u7684PET\u6210\u50cf<\/p>\n

\u56fe<\/b><\/strong>3 <\/b><\/strong>89<\/b><\/sup><\/strong>Zr-Df-MCLs<\/b><\/strong>\u7684\u80bf\u7624\u9776\u5411\u548c\u6cbb\u7597<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(A)\u542b\u67094T1\u80bf\u7624\u7684\u5c0f\u9f20\u5728\u9759\u8109\u6ce8\u5c0489<\/sup>Zr-Df-MCLs\u540e\u5728\u4e0d\u540c\u65f6\u95f4\u70b9\u7684PET\u6210\u50cf<\/p>\n

(B)\u80bf\u7624\u5185\u4e0d\u540c\u65f6\u95f4\u70b9\u7684\u9759\u8109\u6ce8\u5c0489<\/sup>Zr-Df-MCLs\u542b\u91cf<\/p>\n

(C)\u542b\u67094T1\u80bf\u7624\u7684\u5c0f\u9f20\u5728\u9759\u8109\u6ce8\u5c0489<\/sup>Zr-Df-MCLs 72\u5c0f\u65f6\u540e\uff0c89Zr-Df-MCLs\u5728\u4e0d\u540c\u5668\u5b98\u4e2d\u7684\u5206\u5e03<\/p>\n

(D)\u5c0f\u9f20\u7ecf\u8fc7\u4e0d\u540c\u5904\u7406\u8fc7\u7a0b\u540e\u7684\u4f53\u91cd\u53d8\u5316<\/p>\n

(E)\u5c0f\u9f20\u7ecf\u8fc7\u4e0d\u540c\u5904\u7406\u8fc7\u7a0b\u540e\uff0c\u4f53\u5185\u7684\u80bf\u7624\u53d8\u5316<\/p>\n

\u56fe<\/b><\/strong>4<\/b><\/strong>\u00a0\u6dcb\u5df4\u7ed3\u7684<\/b><\/strong>PET<\/b><\/strong>\u6210\u50cf<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(A)89<\/sup>Zr-Df-MCLs\u5c0f\u9f20\u8db3\u4e0b\u6ce8\u5c04\u540e\uff0c\u5728\u4e0d\u540c\u65f6\u95f4\u70b9\u7684\u6dcb\u5df4\u7ed3PET\u6210\u50cf<\/p>\n

(B)\u5728\u4e0d\u540c\u65f6\u95f4\u70b9\uff0c\u5c0f\u9f20\u8db3\u4e0b\u548c\u6dcb\u5df4\u7ed3\u4e2d\u768489<\/sup>Zr-Df-MCLs\u542b\u91cf<\/p>\n

(C)\u8db3\u4e0b\u6ce8\u5c0424\u5c0f\u65f6\u540e\uff0c\u4f53\u5185\u548c\u4f53\u5916\u5c0f\u9f20\u8db3\u4e0b\u548c\u6dcb\u5df4\u7ed3\u768489<\/sup>Zr-Df-MCLs\u542b\u91cf<\/p>\n

(D)\u8db3\u4e0b\u6ce8\u5c0424\u5c0f\u65f6\u540e\uff0c\u6dcb\u5df4\u7ed3\u548c\u5c0f\u9f20\u7684\u4f53\u5916PET\u6210\u50cf<\/p>\n

\u3010\u5c0f\u7ed3<\/b><\/strong>\u3011<\/p>\n

\u8fd9\u4e2a\u5de5\u4f5c\u8bbe\u8ba1\u4e86\u4e00\u79cd\u4ee5\u7ec6\u80de\u819c\u91cd\u7ec4\u88c5\u7684\u65b9\u6cd5\u6765\u6784\u5efa\u591a\u5ba4\u8102\u8d28\u4f53\u3002\u591a\u5ba4\u8102\u8d28\u4f53\u4e0ep-SCN-deferoxamine\u8fde\u63a5\uff0c\u901a\u8fc7\u540e\u8005\u7684\u87af\u5408\u4f5c\u7528\uff0c\u6784\u5efa\u4e8689<\/sup>Zr-Df-MCLs\u300289<\/sup>Zr-Df-MCL\u8868\u73b0\u51fa\u4e86\u5353\u8d8a\u7684\u653e\u5c04\u5316\u5b66\u7a33\u5b9a\u6027\u3001\u66f4\u597d\u7684\u80bf\u7624\u6e17\u900f\u6027\u548c\u6ede\u7559\u6548\u679c\uff1b\u5728\u4fdd\u6301\u957f\u671f\u4e14\u6709\u6548\u7684\u5149\u52a8\u529b\u5b66\u6cbb\u7597\u6548\u679c\u540c\u65f6\uff0c\u4e5f\u80fd\u901a\u8fc7\u809d\u810f\u6392\u6cc4\u4ece\u4f53\u5185\u6e05\u9664\u3002\u6b64\u5de5\u4f5c\u4e3a\u540e\u7eed\u7684\u764c\u75c7\u7eb3\u7c73\u8bca\u7597\u5de5\u4f5c\u63d0\u4f9b\u4e86\u4e00\u79cd\u65b0\u7684\u601d\u8def\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1a<\/strong>Reassembly of\u00a089<\/sup>Zr-Labeled Cancer Cell Membranes into Multicompartment Membrane-Derived Liposomes for PET-Trackable Tumor-Targeted Theranostics<\/a>. (Adv. Mater., 2018, DOI: 10.1002\/adma.201704934)<\/p>\n

\u3010\u4f5c\u8005\u7b80\u4ecb<\/b><\/strong>\u3011<\/p>\n

\u5f20\u6657<\/b><\/strong>\uff0c\u6df1\u5733\u5927\u5b66<\/b><\/strong>\u7279\u8058\u6559\u6388\u3001\u6df1\u5733\u5e02\u9ed1\u78f7\u5149\u7535\u6280\u672f\u5de5\u7a0b\u5b9e\u9a8c\u5ba4<\/b><\/strong>\u4e3b\u4efb\u3002\u9996\u5c4a\u57fa\u91d1\u59d4\u4f18\u9752\u3001\u4e2d\u7ec4\u90e8\u9752\u5343\u3001\u7701\u6770\u9752\u7b49\u3002\u4e3b\u8981\u4ece\u4e8b\u4e8c\u7ef4\u6750\u6599\u4fe1\u606f\u5149\u7535\u5b50\u4e0e\u751f\u7269\u5149\u5b50\u6280\u672f\u7814\u7a76\u7814\u7a76\uff0c\u8fd1\u4e94\u5e74\u6765\uff0c\u4ee5\u901a\u4fe1\u4f5c\u8005\u53d1\u8868\u4e2d\u79d1\u9662\u4e00\u533a\u8bba\u658750\u4f59\u7bc7\uff0c\u5305\u62ecPNAS\u3001Nature Communications\u7b49\uff0c\u5c01\u9762\u8bba\u6587\u8d85\u8fc730\u7bc7\u3002\u8bba\u6587\u603bSCI\u5f15\u7528\u8d85\u8fc71\u4e07\u6b21\uff0cH-index\u4e3a50\uff0c\u4e24\u7bc7\u8bba\u6587\u5165\u9009\u5165\u9009\u4e2d\u56fd\u767e\u7bc7\u6700\u5177\u5f71\u54cd\u529b\u56fd\u9645\u5b66\u672f\u8bba\u6587\u3002\u517c\u4efb\u6c11\u76df\u4e2d\u592e\u59d4\u5458\u3001\u5e7f\u4e1c\u7701\u653f\u534f\u59d4\u5458\u3001\u6df1\u5733\u5e02\u653f\u534f\u59d4\u5458\u3001 \u300aPhotonics Research\u300b\u7b49\u591a\u4e2aSCI\u671f\u520a\u526f\u4e3b\u7f16\u3001\u4e2d\u56fd\u6fc0\u5149\u9752\u5e74\u7f16\u59d4\u4f1a\u79d8\u4e66\u957f\u7b49\u3002<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u5b66\u672f\u7ec4gaxy\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u6574\u7406\u7f16\u8f91\u3002 \u00a0<\/p>\n

\u6750\u6599\u725b\u7f51\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u662f\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c\u70b9\u6211\u52a0\u5165\u7f16\u8f91\u90e8\u5927\u5bb6\u5ead<\/a>\u3002 \u00a0<\/p>\n

\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1tougao@cailiaoren.com\u3002<\/p>\n

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