{"id":127588,"date":"2018-03-03T06:30:54","date_gmt":"2018-03-02T22:30:54","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=127588"},"modified":"2018-03-01T21:46:11","modified_gmt":"2018-03-01T13:46:11","slug":"%e5%90%b4%e5%af%8c%e6%a0%b9%e9%99%88%e6%88%98-jacs-%e4%b8%80%e7%a7%8d%e5%85%89%e8%b0%83%e6%8e%a7%e7%9a%84%e7%bb%86%e8%83%9e%e6%a0%b8%e8%8d%af%e7%89%a9%e9%80%92%e9%80%81%e5%b9%b3%e5%8f%b0","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=127588","title":{"rendered":"\u5434\u5bcc\u6839&\u9648\u6218 JACS: \u4e00\u79cd\u5149\u8c03\u63a7\u7684\u7ec6\u80de\u6838\u836f\u7269\u9012\u9001\u5e73\u53f0"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n

\u7ec6\u80de\u6838\u662f\u7ec6\u80de\u7684\u63a7\u5236\u4e2d\u5fc3\uff0c\u5728\u7ec6\u80de\u7684\u751f\u957f\u3001\u4ee3\u8c22\u3001\u5206\u5316\u548c\u6b7b\u4ea1\u7b49\u8fc7\u7a0b\u4e2d\u8d77\u7740\u91cd\u8981\u7684\u4f5c\u7528\u3002\u540c\u65f6\uff0c\u7ec6\u80de\u6838\u7684\u529f\u80fd\u5f02\u6837\u4e0e\u764c\u75c7\u3001\u5fc3\u529f\u80fd\u4e0d\u5168\u548c\u8111\u5931\u8c03\u7b49\u75be\u75c5\u7684\u4ea7\u751f\u606f\u606f\u76f8\u5173\uff0c\u56e0\u6b64\u7ec6\u80de\u6838\u6210\u4e3a\u8bb8\u591a\u836f\u7269\u6700\u91cd\u8981\uff0c\u4e5f\u662f\u6700\u7ec8\u7684\u9776\u70b9\u3002\u7136\u800c\uff0c\u7531\u4e8e\u7ec6\u80de\u6444\u53d6\u836f\u7269\u7684\u8fc7\u7a0b\u975e\u5e38\u590d\u6742\uff0c\u5982\u4f55\u5c06\u836f\u7269\u9ad8\u6548\u7684\u9012\u9001\u5230\u7ec6\u80de\u6838\u4e2d\u4f9d\u65e7\u662f\u4e9f\u9700\u89e3\u51b3\u7684\u4e00\u5927\u96be\u9898\u3002\u836f\u7269\u7684\u7ec6\u80de\u6838\u9012\u9001\u9762\u4e34\u7740\u4ee5\u4e0b\u51e0\u91cd\u5c4f\u969c\uff0c\u9996\u5148\u9700\u8981\u4f7f\u836f\u7269\u987a\u5229\u901a\u8fc7\u7ec6\u80de\u819c\uff0c\u5bcc\u96c6\u5728\u7ec6\u80de\u5185\u90e8\u3002\u5176\u6b21\uff0c\u5f88\u591a\u836f\u7269\u5728\u8fdb\u5165\u7ec6\u80de\u540e\u4e0d\u53ef\u907f\u514d\u5730\u88ab\u6eb6\u9176\u4f53\u6355\u83b7\u5e76\u4e14\u96be\u4ee5\u4ece\u6eb6\u9176\u4f53\u9003\u9038\uff0c\u5728\u6eb6\u9176\u4f53\u4e2d\u504f\u9178\u6027\u7684\u73af\u5883\u4e0b\u53d1\u751f\u964d\u89e3\uff0c\u5bfc\u81f4\u5176\u4e0d\u80fd\u8fdb\u5165\u7ec6\u80de\u6838\u4e2d\u53d1\u6325\u836f\u6548\u3002\u6b64\u5916\uff0c\u7ec6\u80de\u6838\u8868\u9762\u5b58\u5728\u6838\u5b54\u590d\u5408\u7269\uff0c\u901a\u5e38\u53ea\u80fd\u5141\u8bb8\u5c0f\u5206\u5b50\u91cf\u7684\u7269\u8d28\u81ea\u7531\u8fdb\u51fa\u7ec6\u80de\u6838\uff0c\u800c\u5206\u5b50\u91cf\u8f83\u5927\u7684\u7269\u8d28\u53ca\u7c92\u5f84\u8f83\u5927\u7684\u7eb3\u7c73\u9897\u7c92\u5219\u96be\u4ee5\u7a7f\u8fc7\u6838\u5b54\u590d\u5408\u7269\u3002\u56e0\u6b64\uff0c\u5bf9\u4e8e\u5f88\u591a\u7eb3\u7c73\u836f\u7269\u800c\u8a00\uff0c\u5373\u4f7f\u5b83\u4eec\u80fd\u591f\u6210\u529f\u5730\u4ece\u6eb6\u9176\u4f53\u9003\u9038\uff0c\u4f46\u7531\u4e8e\u6838\u5b54\u590d\u5408\u7269\u7684\u963b\u62e6\uff0c\u8fd9\u4e9b\u7eb3\u7c73\u836f\u7269\u4f9d\u7136\u65e0\u6cd5\u8fbe\u5230\u7ec6\u80de\u6838\uff0c\u4ece\u800c\u6781\u5927\u9650\u5236\u4e86\u5176\u836f\u6548\u7684\u53d1\u6325\u3002\u76ee\u524d\u6700\u5e38\u7528\u7684\u836f\u7269\u8fdb\u6838\u7b56\u7565\u662f\u5229\u7528\u6838\u5b9a\u4f4d\u591a\u80bd\u6765\u589e\u5f3a\u7ec6\u80de\u6838\u5bf9\u7eb3\u7c73\u836f\u7269\u7684\u6444\u53d6\uff0c\u4f46\u8fd9\u79cd\u65b9\u6cd5\u7684\u8fdb\u6838\u6548\u7387\u5341\u5206\u6709\u9650\uff0c\u5e76\u4e14\u4e0d\u9002\u7528\u4e8e\u7c92\u5f84\u8f83\u5927\u7684\u7eb3\u7c73\u9897\u7c92\u3002\u56e0\u6b64\uff0c\u5982\u4f55\u53d1\u5c55\u51fa\u4e00\u79cd\u9ad8\u6548\u7684\u8fdb\u6838\u7b56\u7565\u6765\u589e\u5f3a\u5c0f\u5206\u5b50\u836f\u7269\u53ca\u7eb3\u7c73\u836f\u7269\u5728\u7ec6\u80de\u6838\u5185\u7684\u5bcc\u96c6\u6210\u4e3a\u4e86\u4e00\u4e2a\u4e9f\u5f85\u89e3\u51b3\u7684\u95ee\u9898\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u65e5\u524d\uff0c\u4e1c\u5357\u5927\u5b66\u751f\u7269\u79d1\u5b66\u4e0e\u533b\u5b66\u5de5\u7a0b\u5b66\u9662\u3001\u751f\u7269\u7535\u5b50\u5b66\u56fd\u5bb6\u91cd\u70b9\u5b9e\u9a8c\u5ba4<\/strong>\u7684\u5434\u5bcc\u6839\u6559\u6388<\/strong>\u548c\u7f8e\u56fd\u5bc6\u6b47\u6839\u5927\u5b66<\/strong>\u7684\u9648\u6218\u6559\u6388<\/strong>\u5408\u4f5c\uff0c\u5408\u6210\u4e86\u4ee5\u591a\u9762\u4f53\u4f4e\u805a\u500d\u534a\u7845\u6c27\u70f7\uff08POSS\uff09\u4e3a\u6838\u5fc3\uff0c\u63a5\u679d\u6709\u5149\u654f\u5242\u5b5f\u52a0\u62c9\u73ab\u7470\u7ea2\uff08RB\uff09\u548c\u805a\u4e59\u4e8c\u9187\u5206\u5b50\uff08PEG\uff09\u7684\u81ea\u7ec4\u88c5\u7eb3\u7c73\u8f7d\u836f\u5e73\u53f0(PPR NPs)\uff0c\u9996\u6b21\u5b9e\u73b0\u4e86\u5149\u63a7\u7684\u7ec6\u80de\u6838\u819c\u901a\u900f\u6027\u8c03\u8282\uff0c\u5e76\u4fc3\u8fdb\u4e86\u7ec6\u80de\u6838\u5bf9\u5c0f\u5206\u5b50\u836f\u7269\u4ee5\u53ca\u7eb3\u7c73\u6750\u6599\u7684\u6444\u53d6\u3002\u76f8\u5173\u6210\u679c\u4ee5\u9898\u4e3a\u201cDevelopment of a Light-Controlled Nanoplatform for Direct Nuclear Delivery of Molecular and Nanoscale Materials<\/strong>\u201d\u53d1\u8868\u5728Journal of the American Chemical Society<\/strong>\u4e0a\uff0c\u5434\u5bcc\u6839\u6559\u6388\u9648\u6218\u6559\u6388\u4e3a\u8be5\u8bba\u6587\u7684\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff0c\u4e1c\u5357\u5927\u5b66\u7855\u58eb\u751f\u795d\u96c5\u7487<\/strong>\u548c\u535a\u58eb\u751f\u8d3e\u6d69\u7136<\/strong>\u4e3a\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\u3002\u4e1c\u5357\u5927\u5b66\u4e3a\u8be5\u8bba\u6587\u7b2c\u4e00\u5b8c\u6210\u5355\u4f4d\u3002\u76f8\u5173\u5de5\u4f5c\u5f97\u5230\u4e86\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u3001\u6c5f\u82cf\u7701\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u4f18\u79c0\u9752\u5e74\u57fa\u91d1\u3001\u4e2d\u592e\u9ad8\u6821\u57fa\u672c\u79d1\u7814\u4e13\u9879\u8d44\u91d1\u3001\u6c5f\u82cf\u7701\u9ad8\u5c42\u6b21\u521b\u65b0\u521b\u4e1a\u4eba\u624d\u5f15\u8fdb\u8ba1\u5212\uff08\u5373\u201c\u53cc\u521b\u4eba\u624d\u201d\uff09\u548c\u6c5f\u82cf\u7701\u201c\u516d\u5927\u4eba\u624d\u9ad8\u5cf0\u201d\u8ba1\u5212\u7684\u652f\u6301\u3002<\/p>\n

\u3010\u56fe\u6587\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u56fe1 PPR NPs\u5408\u6210\u53ca\u7ec6\u80de\u6838\u5c0f\u5206\u5b50\u836f\u7269\u9012\u9001\u793a\u610f\u56fe<\/strong><\/p>\n

\"\"<\/p>\n

(a) PPR NPs\u5408\u6210\u53ca\u7ec4\u88c5\u793a\u610f\u56fe\uff1b<\/p>\n

(b) PPR NPs \u7ec6\u80de\u5185\u541e\u53ca\u5149\u4fc3\u6eb6\u9176\u4f53\u91ca\u653e\u53ca\u7ec6\u80de\u6838\u819c\u901a\u900f\u6027\u8c03\u8282\u793a\u610f\u56fe\u3002<\/p>\n

\u56fe2 PPR NPs\u6750\u6599\u8868\u5f81\u53ca\u7ec6\u80de\u5185\u541e\u56fe<\/strong><\/p>\n

\"\"<\/p>\n

(a) PPR NPs \u7684\u52a8\u6001\u5149\u6563\u5c04\u8868\u5f81\u7ed3\u679c\u53ca\u900f\u5c04\u7535\u955c\u56fe\uff1b<\/p>\n

(b) RB\u548cPPR NPs\u7684\u8367\u5149\u53d1\u5c04\u5149\u8c31\uff1b<\/p>\n

(c) RB\u548cPPR NPs\u5728532 nm\u6fc0\u5149\u7167\u5c04\u4e0b\u7684\u5355\u7ebf\u6001\u6c27\u4ea7\u751f\u60c5\u51b5\uff1b<\/p>\n

(d) RB\u548cPPR NPs\u4e0e\u4eba\u80ba\u764c\u7ec6\u80de\uff08A549\uff09\u5171\u5b75\u80b2\u540e\u7684\u5171\u805a\u7126\u6210\u50cf\u6548\u679c\u56fe\uff1b<\/p>\n

(e) PPR NPs\u57284\u2103\u53ca\u53e0\u6c2e\u5316\u94a0\u5904\u7406\u4e0b\u4e0eA549\u5171\u5b75\u80b2\u540e\u7684\u5171\u805a\u7126\u6210\u50cf\u56fe\uff1b<\/p>\n

(f) PPR NPs \u5904\u7406\u7684A549\u7ec6\u80de\u4e0e\u6eb6\u9176\u4f53\u67d3\u6599\u7684\u5171\u5b9a\u4f4d\u6548\u679c\u56fe\u3002<\/p>\n

\u56fe3 PPR NPs\u5149\u7167\u7834\u574f\u6eb6\u9176\u4f53\u53ca\u7ec6\u80de\u6838\u819c\u5bcc\u96c6\u6548\u679c\u56fe<\/strong><\/p>\n

\"\"<\/p>\n

(a) A549\u7ec6\u80de\u5149\u7167\u524d\u540e\u7684\u5416\u5576\u6a59\u67d3\u8272\u6210\u50cf\u6548\u679c\u56fe\uff1b<\/p>\n

(b) PPR NPs\u5728\u4e0d\u540cpH\u4e0b\u7684\u5355\u7ebf\u6001\u6c27\u4ea7\u751f\uff1b<\/p>\n

(c) PPR NPs \u5728\u4e0d\u540cpH\u4e0b\u7684\u8367\u5149\u53d1\u5c04\u5149\u8c31\uff1b<\/p>\n

(d) PPR NPs\u5904\u7406\u8fc7\u7684A549\u7ec6\u80de\u5728\u5149\u7167\u524d\u540e\u4e0e\u7ec6\u80de\u6838\u67d3\u6599Hoechst33342\u5171\u67d3\u7684\u6210\u50cf\u6548\u679c\u56fe\uff1b<\/p>\n

(e) \u56fed\u4e2dPPR NPs\u53caHoechst33342\u8367\u5149\u7edf\u8ba1\u56fe\u3002<\/p>\n

\u56fe4 PPR NPs\u4fc3\u8fdb\u7eb3\u7c73\u9897\u7c92\u8fdb\u6838\u6548\u679c<\/strong><\/p>\n

\"\"<\/p>\n

(a)PPR NPs\u8c03\u63a7\u6838\u819c\u901a\u900f\u6027\u5e76\u4fc3\u8fdb\u5927\u5c3a\u5bf8\u7eb3\u7c73\u9897\u7c92\u8fdb\u6838\u793a\u610f\u56fe\uff1b<\/p>\n

(b)PPR NPs\u5728\u5149\u7167\u6761\u4ef6\u4e0b\u534f\u52a9\u666e\u9c81\u58eb\u84dd\u548c\u91d1\u7eb3\u7c73\u68d2\u8fdb\u5165\u7ec6\u80de\u6838\u6210\u50cf\u56fe\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

\u672c\u5de5\u4f5c\u5408\u6210\u4e86\u4ee5POSS\u4e3a\u6838\u5fc3\uff0c\u63a5\u679d\u6709\u5149\u654f\u5242RB\u53caPEG\u5206\u5b50\u7684\u7eb3\u7c73\u81ea\u7ec4\u88c5\u7ed3\u6784\uff0c\u901a\u8fc7pH\u54cd\u5e94\u7684\u5355\u7ebf\u6001\u6c27\u4ea7\u751f\u53ca\u591a\u6c28\u57fa\u5f15\u8d77\u7684\u8d28\u5b50\u6d77\u7ef5\u6548\u5e94\u5b9e\u73b0\u4e86\u5149\u63a7\u7684\u6eb6\u9176\u4f53\u9003\u9038\uff0c\u5e76\u4e14\u8fdb\u4e00\u6b65\u5bcc\u96c6\u4e8e\u6838\u819c\u533a\u57df\u5b9e\u73b0\u4e86\u7ec6\u80de\u6838\u819c\u901a\u900f\u6027\u7684\u8c03\u8282\u3002\u6b64\u5916\uff0c\u8be5\u6750\u6599\u4e0d\u4ec5\u80fd\u591f\u4f5c\u4e3a\u7eb3\u7c73\u8f7d\u4f53\u88c5\u8f7d\u5c0f\u5206\u5b50\u7269\u8d28\u5b9e\u73b0\u9ad8\u6548\u8fdb\u6838\uff0c\u8fd8\u80fd\u591f\u901a\u8fc7\u8fd9\u79cd\u5149\u89e6\u53d1\u7834\u574f\u6838\u819c\u7684\u65b9\u6cd5\u5b9e\u73b0\u5176\u4ed6\u7eb3\u7c73\u9897\u7c92\uff08\u5982\u91d1\u7eb3\u7c73\u68d2\u548c\u666e\u9c81\u58eb\u84dd\u7eb3\u7c73\u9897\u7c92\uff09\u7684\u8fdb\u6838\u3002\u76f8\u6bd4\u4e8e\u5e38\u89c1\u7684\u7ec6\u80de\u6838\u836f\u7269\u9012\u9001\u7b56\u7565\uff08\u5982\u6838\u5b9a\u4f4d\u591a\u80bd\u4fee\u9970\uff09\uff0c\u8fd9\u79cd\u5229\u7528\u5149\u8c03\u63a7\u7269\u8d28\u8fdb\u6838\u7684\u65b9\u6cd5\u53ef\u63a7\u6027\u5f3a\uff0c\u8fdb\u6838\u6548\u7387\u9ad8\uff0c\u6253\u7834\u4e86\u6838\u5b54\u5bf9\u8fdb\u6838\u7269\u8d28\u5c3a\u5bf8\u548c\u5f62\u8c8c\u7684\u9650\u5236\uff0c\u5e76\u4e14\u5177\u6709\u5f88\u597d\u7684\u666e\u9002\u6027\u3002<\/p>\n

\u6587\u7ae0\u94fe\u63a5\uff1aDevelopment of a Light-Controlled Nanoplatform for Direct Nuclear Delivery of Molecular and Nanoscale Materials.<\/a><\/strong>\uff08JACS\uff0c2018\uff0cDOI:\u00a010.1021\/jacs.7b13672\uff09<\/p>\n

\u672c\u6587\u7531\u5434\u5bcc\u6839<\/b><\/strong>\u6559\u6388\u548c\u9648\u6218<\/b><\/strong>\u6559\u6388\u56e2\u961f\u4f9b\u7a3f\u3002<\/p>\n

\u6750\u6599\u4eba\u7f51\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u662f\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c\u70b9\u6211\u52a0\u5165\u7f16\u8f91\u90e8<\/a>\u3002<\/p>\n

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