{"id":131951,"date":"2018-03-26T06:30:13","date_gmt":"2018-03-25T22:30:13","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=131951"},"modified":"2018-03-26T01:56:07","modified_gmt":"2018-03-25T17:56:07","slug":"%e5%8d%8e%e7%a7%91%e6%9d%a8%e5%9d%a4%e7%a6%b9acs-nano-%e6%b3%a8%e5%b0%84%e6%b0%b4%e5%87%9d%e8%83%b6%e8%82%bd%e4%b8%8e%e5%85%8d%e7%96%ab%e6%b2%bb%e7%96%97","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=131951","title":{"rendered":"\u534e\u79d1\u6768\u5764\u79b9ACS Nano :\u6ce8\u5c04\u6c34\u51dd\u80f6\u80bd\u4e0e\u514d\u75ab\u6cbb\u7597"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n

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\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u7ebd\u7ea6\u5dde\u7acb\u5927\u5b66\u7684Jonathan F. Lovell\u6559\u6388\u548c\u534e\u4e2d\u79d1\u6280\u5927\u5b66\u7684\u6768\u5764\u79b9\u6559\u6388\uff08\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u7b49\u4eba\u5f00\u53d1\u4e86\u4e00\u79cd\u8702\u6bd2\u80bd-RADA32\u6df7\u5408\u6210\u6c34\u51dd\u80f6\u80bd\uff0c\u901a\u8fc7\u5bf9\u514d\u75ab\u6291\u5236\u80bf\u7624\u5fae\u73af\u5883\u7684\u6709\u6548\u8c03\u63a7\uff0c\u5728\u6297\u9ed1\u7d20\u7624\u4e2d\u8fdb\u884c\u6709\u6548\u7684\u5316\u5b66\u514d\u75ab\u6cbb\u7597\u3002\u5f62\u6210\u7684\u8702\u6bd2\u80bd-RADA32-DOX (MRD)\u6c34\u51dd\u80f6\u5177\u6709\u4ea4\u7ec7\u7684\u7eb3\u7c73\u7ea4\u7ef4\u7ed3\u6784\uff0c\u5177\u6709\u826f\u597d\u7684\u751f\u7269\u76f8\u5bb9\u6027\uff0c\u5728\u4f53\u5916\u548c\u4f53\u5185\u90fd\u5177\u6709\u53d7\u63a7\u7684\u836f\u7269\u91ca\u653e\u7279\u6027\uff0c\u5bf9\u9ed1\u7d20\u7624\u7ec6\u80de\u5177\u6709\u589e\u5f3a\u7684\u6740\u4f24\u4f5c\u7528\u3002\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a\u201cTumor Ablation and Therapeutic ImmunityInduction by an Injectable Peptide Hydrogel<\/strong>\u201d\u53d1\u5e03\u5728\u56fd\u9645\u8457\u540d\u671f\u520aACS Nano<\/strong>\u4e0a\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe1.MRD\u6c34\u51dd\u80f6\u7684\u5236\u5907\u53ca\u8868\u5f81<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09 MRD\u5bf9\u9ed1\u7d20\u7624\u7684\u6297\u80bf\u7624\u4f5c\u7528\u673a\u7406\u56fe\uff1b<\/p>\n

\uff08b\uff09 MRD\u6c34\u51dd\u80f6\u8d1f\u8f7d\u5404\u79cd\u836f\u7269\u7684\u7167\u7247\u56fe\uff1b<\/p>\n

\uff08c\uff09 MR\u548cMRD\u7684TEM\u56fe\uff1b<\/p>\n

\uff08d\uff09 MRD\u6c34\u51dd\u80f6\u7684\u9891\u7387\u626b\u63cf\u6d41\u53d8\u5206\u6790\u56fe\uff1b<\/p>\n

\uff08e\uff09 MRD\u6c34\u51dd\u80f6\u7684\u9636\u68af\u6027\u5e94\u53d8\u65f6\u95f4\u53d8\u5316\u6d41\u53d8\u5206\u6790\u56fe\uff1b<\/p>\n

\uff08f\uff09 MR\u6eb6\u6db2\u3001MR\u80bd\u3001MR\u6c34\u51dd\u80f6\u3001MRD\u6c34\u51dd\u80f6\u7684CD\u56fe\u50cf\uff1b<\/p>\n

\uff08g\uff09 \u5728\u86cb\u767d\u9176K\u5b58\u5728\u6216\u4e0d\u5b58\u5728\u65f6\uff0cMRD\u6c34\u51dd\u80f6\u7684\u91ca\u653e\u56fe\uff1b<\/p>\n

\uff08h\uff09 \u5728\u86cb\u767d\u9176K\u5b58\u5728\u6216\u4e0d\u5b58\u5728\u65f6\uff0cMR\u6c34\u51dd\u80f6\u7684\u91ca\u653e\u56fe\u3002<\/p>\n

\u56fe2.MRD\u6c34\u51dd\u80f6\u7684\u4f53\u5916\u6297\u80bf\u7624\u6548\u679c<\/strong><\/p>\n

\"\"<\/p>\n

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\u56fe3.MRD\u6c34\u51dd\u80f6\u7684\u4f53\u5916\u6297\u80bf\u7624\u673a\u7406\u548c\u514d\u75ab\u4f5c\u7528<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09MR\u6c34\u51dd\u80f6\u4f5c\u7528B16-GFP\u7ec6\u80de\u7684CLSM\u56fe\uff1b<\/p>\n

\uff08b\uff09\u5728\uff08a\uff09\u4e2d\u6240\u5448\u73b0\u7684CLSM\u56fe\u50cf\u7814\u7a76\uff1b<\/p>\n

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\uff08e\u3001f\uff09MR\u6c34\u51dd\u80f6\u5904\u7406\u540eDC\u8868\u9762\u6807\u5fd7\u7269CD80\u548cCD86\u8868\u8fbe\u6c34\u5e73\u56fe\uff1b<\/p>\n

\uff08g\uff09MR\u6c34\u51dd\u80f6\u8bf1\u5bfc\u80bf\u7624\u7ec6\u80de\u6b7b\u4ea1\u5bf9\u6210\u719fDCs\u7684\u5f71\u54cd\u56fe\u3002<\/p>\n

\u56fe4.MRD\u6c34\u51dd\u80f6\u5728\u4f53\u5185\u836f\u7269\u91ca\u653e\u6982\u51b5\u548c\u6297\u80bf\u7624\u4f5c\u7528<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09 \u5728\u4e0d\u540c\u65f6\u95f4\u70b9\uff0c\u76ae\u4e0b\u6ce8\u5c04MR-Cy7\u548cCy7\u67d3\u6599\u7684\u8fd1\u7ea2\u5916\u4f53\u5185\u8367\u5149\u6210\u50cf\u56fe\uff1b<\/p>\n

\uff08b\uff09 \u4ece\uff08a\uff09\u4e2d\u7684\u5b9a\u91cf\u6570\u636e\u56fe\uff1b<\/p>\n

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\uff08d\uff09 \u5728\u76f8\u5e94\u6cbb\u7597\u7ec4\uff0c\u5177\u6709CR\u7684\u5c0f\u9f20\u80bf\u7624\u767e\u5206\u6bd4\uff1b<\/p>\n

\uff08e\uff09 \u5728\uff08c\uff09\u4e2d\u6240\u8ff0\u76f8\u5e94\u6cbb\u7597\u7ec4\u7684\u5b58\u6d3b\u7387\u56fe\u3002<\/p>\n

\u56fe5.\u8840\u6db2\u5206\u6790\u548c\u751f\u5316\u5206\u6790<\/strong><\/p>\n

\"\"<\/p>\n

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\uff08b\uff09 \u4e3b\u8981\u5668\u5b98\u7684\u7ec4\u7ec7\u5b66\u68c0\u6d4b\u56fe\u3002<\/p>\n

\u56fe6.MRD\u6c34\u51dd\u80f6\u5728\u4f53\u5185\u7684\u514d\u75ab\u6d3b\u5316\u4f5c\u7528<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09 MRD\u6c34\u51dd\u80f6\u7684\u514d\u75ab\u6cbb\u7597\u5206\u6790\u65b9\u6848\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08b\uff09 \u5728PLNs\u4e2d\u6fc0\u6d3bDCs\u7684\u767e\u5206\u6bd4\u56fe\uff1b<\/p>\n

\uff08c\uff09 \u5728\u80bf\u7624\u4e2d\u6fc0\u6d3bNKs\u7684\u767e\u5206\u6bd4\u56fe\uff1b<\/p>\n

\uff08d\uff09 \u6d4b\u91cfM1-like\u548cM2-like TAMs\u7684\u7ec6\u80de\u6d41\u5f0f\u56fe\uff1b<\/p>\n

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\uff08f\uff09 \u5728\u4e0d\u540c\u6cbb\u7597\u7ec4\u7684\u80bf\u7624\u5185\uff0cM2\/\u603b\u5de8\u566c\u7ec6\u80de\u7684\u767e\u5206\u6bd4\uff1b<\/p>\n

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\uff08h\uff09 \u6bcf\u7ec4\u80bf\u7624\u4e2dCD8+<\/sup>T\u7ec6\u80de\u767e\u5206\u6bd4\uff1b<\/p>\n

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\uff08j\uff09 \u6bcf\u7ec4\u80bf\u7624\u5185CD8+<\/sup> IFN\u03b3+<\/sup> T\u7ec6\u80de\u7684\u90e8\u5206\u6bd2\u6027\u5b9e\u9a8c\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

\u7814\u7a76\u5f00\u53d1\u4e86\u4e00\u79cd\u529f\u80fd\u5f3a\u5927\u7684\u80bd\u6c34\u51dd\u80f6 – MRD\u6c34\u51dd\u80f6\u3002\u5b83\u5728\u6c34\u51dd\u80f6\u9aa8\u67b6\u4e2d\u5305\u88f9\u4e86\u8702\u6bd2\u80bd\u548cDOX\u3002\u8fd9\u79cd\u6c34\u51dd\u80f6-\u80bd\u662f\u53ef\u4ee5\u901a\u8fc7\u91cd\u5851\u514d\u75ab\u6291\u5236TMEs\u800c\u6709\u6548\u7684\u8054\u5408\u6cbb\u7597\u9ed1\u7d20\u7624\u3002\u7531\u4e8e\u5176\u63a7\u5236\u7684\u836f\u7269\u91ca\u653e\u7279\u6027\u53ca\u5176\u5bf9\u5148\u5929\u6027\u514d\u75ab\u7ec6\u80de\u7684\u8c03\u8282\u80fd\u529b\uff0c\u6d88\u8017M2-like\u7684TAMs\uff0c\u4ee5\u53ca\u76f4\u63a5\u6297\u764c\u548c\u514d\u75ab\u523a\u6fc0\uff0c\u4f7f\u5f97MRD\u6c34\u51dd\u80f6\u5bf9\u76ae\u4e0b\u7624\u548c\u8f6c\u79fb\u7624\u6709\u5f3a\u5927\u7684\u6297\u764c\u4f5c\u7528\u3002MRD\u6c34\u51dd\u80f6\u53ef\u4ee5\u8fdb\u4e00\u6b65\u7528\u4e8e\u5728\u4f53\u5185\u6839\u9664\u9ed1\u8272\u7d20\u7624\uff0c\u5e76\u5f15\u8d77\u5f3a\u70c8\u7684\u514d\u75ab\u8bb0\u5fc6\u6548\u5e94\uff0c\u800c\u6210\u4e3a\u6297\u764c\u5e94\u7528\u7684\u6709\u529b\u5de5\u5177\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aTumor Ablation and Therapeutic Immunity Induction by an Injectable Peptide Hydrogel<\/a>\uff08ACS Nano, 2018, DOI:10.1021\/acsnano.7b08148\uff09<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u7f16\u8f91\u90e8\u5411\u798f\u6e05\u7f16\u8bd1\uff0c\u5468\u68a6\u9752\u5ba1\u6838\uff0c\u70b9\u6211\u52a0\u5165\u6750\u6599\u4eba\u7f16\u8f91\u90e8<\/a>\u3002<\/p>\n

\u6750\u6599\u6d4b\u8bd5\uff0c\u6570\u636e\u5206\u6790\uff0c\u4e0a\u6d4b\u8bd5\u8c37<\/a>\uff01<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

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