{"id":146159,"date":"2018-07-17T14:00:16","date_gmt":"2018-07-17T06:00:16","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=146159"},"modified":"2018-07-15T15:21:01","modified_gmt":"2018-07-15T07:21:01","slug":"%e6%b5%99%e5%a4%a7%e5%91%a8%e6%b0%91%e5%9b%a2%e9%98%9fadv-funct-mater-%e5%b0%81%e9%9d%a2%e6%96%87%e7%ab%a0%ef%bc%9a%e9%80%9a%e8%bf%87%e5%85%89%e6%bf%80%e6%b4%bb%e7%9a%84%e7%bb%84%e8%a3%85%e7%ba%b3","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=146159","title":{"rendered":"\u6d59\u5927\u5468\u6c11\u56e2\u961fAdv. Funct. Mater.\u5c01\u9762\u6587\u7ae0\uff1a\u901a\u8fc7\u5149\u6fc0\u6d3b\u7684\u7ec4\u88c5\u7eb3\u7c73\u7c92\u5b50\u4ee5\u6539\u5584\u80bf\u7624\u90e8\u4f4d\u7684\u6e17\u900f\u5e76\u6839\u9664\u4e09\u91cd\u9634\u6027\u4e73\u817a\u764c\u7684\u8f6c\u79fb"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-146170\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/07\/cover.jpg\" alt=\"\" width=\"465\" height=\"600\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/07\/cover.jpg 465w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/07\/cover-233x300.jpg 233w\" sizes=\"(max-width: 465px) 100vw, 465px\" \/><\/p>\n<p><strong>\u3010\u5f15\u8a00\u3011<\/strong><strong>\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/strong><\/p>\n<p>\u7eb3\u7c73\u836f\u7269\u7684\u5c3a\u5bf8\u662f\u5176\u5728\u80bf\u7624\u90e8\u4f4d\u5bcc\u96c6\u548c\u6e17\u900f\u7684\u5173\u952e\u56e0\u7d20\uff1a\u5927\u9897\u7c92\u7eb3\u7c73\u836f\u7269\u5177\u8f83\u957f\u8840\u6db2\u5faa\u73af\u534a\u8870\u671f\uff0c\u6709\u5229\u4e8e\u901a\u8fc7EPR \u6548\u5e94\u5728\u80bf\u7624\u90e8\u4f4d\u5bcc\u96c6\uff1b\u5c0f\u9897\u7c92\u7eb3\u7c73\u836f\u7269\u5177\u6709\u8f83\u5f3a\u7684\u6269\u6563\u80fd\u529b\uff0c\u6709\u5229\u4e8e\u5f80\u80bf\u7624\u5185\u90e8\u6e17\u900f\u83b7\u5f97\u66f4\u5747\u5300\u7684\u80bf\u7624\u5206\u5e03\u3002\u7406\u60f3\u7684\u7eb3\u7c73\u8f7d\u836f\u7cfb\u7edf\u5e94\u8be5\u5177\u6709\u5c3a\u5bf8\u53ef\u53d8\u6027\uff0c\u5373\u4ee5\u5927\u9897\u7c92\u5f62\u5f0f\u83b7\u5f97\u80bf\u7624\u9ad8\u5bcc\u96c6\u540e\uff0c\u518d\u88c2\u53d8\u6210\u5c0f\u9897\u7c92\u4ee5\u83b7\u5f97\u80bf\u7624\u5185\u90e8\u7684\u9ad8\u6e17\u900f\u3002<\/p>\n<p><strong>\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n<p>\u8fd1\u65e5\uff0c<strong>\u6d59\u6c5f\u5927\u5b66\u5468\u6c11\u6559\u6388\u3001\u7530\u6885\u6559\u6388\u3001\u5f20\u5b8f\u6559\u6388<\/strong>\u548c<strong>\u82ac\u5170\u8d6b\u5c14\u8f9b\u57fa\u5927\u5b66Helder Santos\u6559\u6388\uff08\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u56e2\u961f\u5728<strong>Advanced Functional Materials<\/strong><strong>\uff08\u300a\u5148\u8fdb\u529f\u80fd\u6750\u6599\u300b\uff09<\/strong>\u6742\u5fd7\u5728\u7ebf\u53d1\u8868\u4e86\u4e00\u7bc7\u9898\u4e3a\u201c<strong>Light-activatable assembled nanoparticles to improve tumor penetration and eradicate metastasis in triple negative breast cancer<\/strong>\u201d\u7684\u6587\u7ae0\uff0c\u4ecb\u7ecd\u4e86\u4e00\u79cd\u5177\u6709\u80bf\u7624\u9ad8\u5bcc\u96c6\u548c\u6e17\u900f\u7684\u7eb3\u7c73\u836f\u7269\u9012\u9001\u7cfb\u7edf<strong>TSNCs<\/strong>\uff0c\u91c7\u7528\u8fd1\u7ea2\u5916\u6fc0\u5149\u7167\u5c04\u4e73\u817a\u764c\u5c0f\u9f20\uff0c\u901a\u8fc7\u5149\u70ed\u6548\u5e94\u53d1\u6325\u6297\u80bf\u7624\u4f5c\u7528\u7684\u540c\u65f6\u4f7f<strong>TSNCs<\/strong>\u5206\u89e3\u4e3a\u5c0f\u9897\u7c92\u836f\u7269\uff0c\u5b9e\u73b0\u836f\u7269\u5728\u80bf\u7624\u7ec4\u7ec7\u7684\u6df1\u5c42\u6e17\u900f\uff0c\u663e\u8457\u63d0\u9ad8\u80bf\u7624\u6cbb\u7597\u6548\u679c\u3002<\/p>\n<p><strong>\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n<p><strong>\u56fe1.TSNCs\u5f62\u8c8c\u548c\u7ed3\u6784\u8868\u5f81<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-146171\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/07\/figure-1.jpg\" alt=\"\" width=\"600\" height=\"405\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/07\/figure-1.jpg 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/07\/figure-1-300x203.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>(A) TSNCs\u7535\u955c\u7167\u7247\uff0c\u6807\u5c3a\uff1a50 nm\uff08\u63d2\u56fe\u4e3a\u5c40\u90e8\u653e\u5927\u9ad8\u6e05\u7167\u7247\uff0c\u6807\u5c3a\uff1a20 nm\uff09\uff1b<\/p>\n<p>(B) TSNCs\u7c92\u5f84\u5927\u5c0f\u5206\u5e03\u56fe\uff1b<\/p>\n<p>(C) TSNCs\u548cDOX\u7d2b\u5916-\u53ef\u89c1-\u8fd1\u7ea2\u5916\u5149\u8c31\uff1b<\/p>\n<p>(D) \u4e0d\u540c\u5f3a\u5ea6808 nm\u6fc0\u5149\u7167\u5c04TSNCs\u6e29\u5ea6\u53d8\u5316\u66f2\u7ebf\uff1b<\/p>\n<p>(E) 808 nm\u6fc0\u5149\u7167\u5c04\u540eTSNCs\u7535\u955c\u7167\u7247\uff1b<\/p>\n<p>(F) 808 nm\u6fc0\u5149\u7167\u5c04\u540eTSNCs\u7c92\u5f84\u5206\u5e03\u56fe\u3002<\/p>\n<p><strong>\u56fe2.TSNCs\u5bf9\u7ec6\u80de\u7684\u6740\u4f24\u8bc4\u4ef7<\/strong><\/p>\n<p><strong><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-146172\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/07\/figure-2.jpg\" alt=\"\" width=\"600\" height=\"429\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/07\/figure-2.jpg 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/07\/figure-2-300x215.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/strong><\/p>\n<p>(A-C) \u4e0d\u540c\u6d53\u5ea6DOX \u548cTSNCs \u5b75\u80b2\u5c0f\u9f20\u6765\u6e90\u4e73\u817a\u764c4T1 \u7ec6\u80de24 \u5c0f\u65f6 (A) 48 \u5c0f\u65f6 (B) \u548c72 \u5c0f\u65f6 (C) \u540e\u7684\u7ec6\u80de\u5b58\u6d3b\u7387\u66f2\u7ebf\u56fe\uff1b<\/p>\n<p>(D) \u6fc0\u5149\u7167\u5c04TSNCs\u91ca\u653eDOX\u5bf9\u7ec6\u80deDNA\u635f\u4f24\u76f8\u5173\u6807\u5fd7\u7269\u03b3H2AX\u7684\u514d\u75ab\u8367\u5149\u56fe\uff1b<\/p>\n<p>(E) \u7ec6\u80deDNA\u635f\u4f24\u5b9a\u91cf\u7ed3\u679c\u3002<\/p>\n<p><strong>\u56fe3. DOX \u548cTSNCs \u57284T1 3D \u80bf\u7624\u7ec6\u80de\u7403\u5185\u7684\u7a7f\u900f\u5b9e\u9a8c\u53ca\u4e0d\u540c\u5904\u7406\u56e0\u7d20\u5bf9\u80bf\u7624\u7ec6\u80de\u6740\u4f24\u8bc4\u4ef7<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-146173\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/07\/figure-3.jpg\" alt=\"\" width=\"404\" height=\"600\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/07\/figure-3.jpg 404w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/07\/figure-3-202x300.jpg 202w\" sizes=\"(max-width: 404px) 100vw, 404px\" \/><\/p>\n<p>(A) DOX \u548cTSNCs \u57284T1 3D \u80bf\u7624\u7ec6\u80de\u7403\u5185\u7684\u7a7f\u900f\u3002\u6fc0\u5149\u5171\u805a\u7126\u663e\u5fae\u955cZ \u8f74\u626b\u63cfDOX\uff0c<\/p>\n<p>TSNCs\u8054\u5408\u6216\u4e0d\u8054\u5408\u8fd1\u7ea2\u5916\u6fc0\u5149\u5904\u7406\u540e\u7684DOX\u8367\u5149\u5206\u5e03, \u6807\u5c3a\u4e3a200 \u03bcm\uff1b<\/p>\n<p>(B) Control\u3001Laser\u3001CuSNDs\u3001TSNCs\u3001DOX\u3001CuSNDs+laser\u548cTSNCs+laser\u5404\u7ec4\u5904\u7406\u56e0\u7d20\u6cbb\u7597\u540e24\u5c0f\u65f64T1 \u80bf\u7624\u7ec6\u80de\u5b58\u6d3b\u7387(*** <em>P<\/em> &lt; 0.001)\u3002<\/p>\n<p><strong>\u56fe4. DOX\u3001CuSNDs\u548cTSNCs \u57284T1\u8377\u7624\u5c0f\u9f20\u4f53\u5185\u4ee3\u8c22\u60c5\u51b5<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-146174\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/07\/figure-4.jpg\" alt=\"\" width=\"408\" height=\"600\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/07\/figure-4.jpg 408w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/07\/figure-4-204x300.jpg 204w\" sizes=\"(max-width: 408px) 100vw, 408px\" \/><\/p>\n<p>(A) \u5c0f\u9f20\u6765\u6e90\u4e73\u817a\u764c4T1\u539f\u4f4d\u7624\u88f8\u9f20\u5c3e\u9759\u8109\u6ce8\u5c04TSNCs \u540e\u4e0d\u540c\u65f6\u95f4\u70b9\u7684\u5149\u58f0\u6210\u50cf\uff1b<\/p>\n<p>(B) \u5c0f\u9f20\u5c3e\u9759\u8109\u6ce8\u5c04TSNCs \u548cCuSNDs24 \u5c0f\u65f6\u5185\u7684\u8840\u6db2\u836f\u4ee3\u52a8\u529b\u5b66\u66f2\u7ebf;<\/p>\n<p>(C) \u4e73\u817a\u764c4T1\u539f\u4f4d\u7624\u88f8\u9f20\u5c3e\u9759\u8109\u6ce8\u5c04TSNCs24\u5c0f\u65f6\u540e\u751f\u7269\u5206\u5e03\u67f1\u72b6\u56fe;<\/p>\n<p>(D) \u4e73\u817a\u764c4T1\u539f\u4f4d\u7624\u88f8\u9f20\u5c3e\u9759\u8109\u6ce8\u5c04DOX \u6216TSNCs 24 \u5c0f\u65f6\u540e\u5c0f\u52a8\u7269\u6d3b\u4f53DOX \u8367\u5149\u6210\u50cf\u56fe\uff1b<\/p>\n<p>(E) \u4e73\u817a\u764c4T1 \u539f\u4f4d\u7624\u88f8\u9f20\u5c3e\u9759\u8109\u6ce8\u5c04DOX \u6216TSNCs 24 \u5c0f\u65f6\u540e\u80bf\u7624\u79bb\u4f53DOX \u8367\u5149\u6210\u50cf\u56fe;<\/p>\n<p>(F) \u5c0f\u52a8\u7269\u6d3b\u4f53DOX\u8367\u5149\u5b9a\u91cf\u56fe\uff1b<\/p>\n<p>(G) \u5c0f\u52a8\u7269\u79bb\u4f53DOX\u8367\u5149\u5b9a\u91cf\u56fe\u3002<\/p>\n<p><strong>\u56fe5. DOX\u548cTSNCs \u57284T1\u8377\u7624\u5c0f\u9f20\u4f53\u5185\u5206\u5e03\u7684\u8367\u5149\u6210\u50cf<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-146163\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/07\/figure-5.jpg\" alt=\"\" width=\"597\" height=\"600\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/07\/figure-5.jpg 597w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/07\/figure-5-150x150.jpg 150w\" sizes=\"(max-width: 597px) 100vw, 597px\" \/><\/p>\n<p>(A) \u5c0f\u9f20\u6765\u6e90\u4e73\u817a\u764c4T1 \u539f\u4f4d\u7624\u88f8\u9f20\u5c3e\u9759\u8109\u6ce8\u5c04DOX \u6216TSNCs 24\u5c0f\u65f6\u540e\u4e3b\u8981\u5668\u5b98\u79bb\u4f53DOX\u8367\u5149\u6210\u50cf\u56fe\uff1b<\/p>\n<p>(B) \u4e73\u817a\u764c4T1\u539f\u4f4d\u7624\u88f8\u9f20\u5c3e\u9759\u8109\u6ce8\u5c04DOX\uff0c TSNCs 24\u5c0f\u65f6\u540e\u4e3b\u8981\u5668\u5b98\u79bb\u4f53DOX \u8367\u5149\u51b0\u51bb\u5207\u7247\u56fe;<\/p>\n<p>(C) 4T1\u539f\u4f4d\u7624\u88f8\u9f20\u5c3e\u9759\u8109\u6ce8\u5c04DOX \u6216TSNCs 24 \u5c0f\u65f6\u540e\u4e3b\u8981\u5668\u5b98\u79bb\u4f53DOX \u8367\u5149\u5b9a\u91cf\u56fe<strong>\u3002<\/strong><\/p>\n<p><strong>\u56fe6. DOX\u3001TSNCs\u548cTSNCs+laser \u57284T1 \u539f\u4f4d\u80bf\u7624\u7ec4\u7ec7\u5185\u8840\u7ba1\u9644\u8fd1\u548c\u8840\u7ba1\u7a00\u5c11\u533a\u57df\u7684\u5206\u5e03<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-146164\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/07\/figure-6.jpg\" alt=\"\" width=\"411\" height=\"600\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/07\/figure-6.jpg 411w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/07\/figure-6-206x300.jpg 206w\" sizes=\"(max-width: 411px) 100vw, 411px\" \/><\/p>\n<p>(A) DOX\u3001TSNCs\u548cTSNCs+laser \u57284T1 \u539f\u4f4d\u80bf\u7624\u7ec4\u7ec7\u5185\u8840\u7ba1\u9644\u8fd1\u548c\u8840\u7ba1\u7a00\u5c11\u533a\u57df\u7684\u5206\u5e03\u3002\u6fc0\u5149\u5171\u805a\u7126\u663e\u5fae\u955c\u626b\u63cf\u5404\u7ec4\u5904\u7406\u540e\u80bf\u7624\u7ec4\u7ec7\u5207\u7247\u7684\u84dd\u8272\u8367\u5149\uff08\u7ec6\u80de\u6838\uff09\u3001\u7ea2\u8272\u8367\u5149\uff08\u8840\u7ba1\u6807\u8bb0\u7269CD34\uff09\u7eff\u8272\u8367\u5149\uff08DOX\uff09\uff0c\u6807\u5c3a\u4e3a50 \u03bcm\uff1b<\/p>\n<p>(B) DOX\u3001TSNCs\u548cTSNCs+laser \u57284T1 \u539f\u4f4d\u80bf\u7624\u7ec4\u7ec7\u5185\u4e4f\u6c27\u533a\u57df\u7684\u5206\u5e03\u3002\u6fc0\u5149\u5171\u805a\u7126\u663e\u5fae\u955c\u626b\u63cf\u5404\u7ec4\u5904\u7406\u540e\u80bf\u7624\u7ec4\u7ec7\u5207\u7247\u7684\u84dd\u8272\u8367\u5149\uff08\u7ec6\u80de\u6838\uff09\u3001\u7ea2\u8272\u8367\u5149\uff08\u4e4f\u6c27\u7ec6\u80de\u6807\u8bb0\u7269HIF-1\u03b1\uff09\u7eff\u8272\u8367\u5149\uff08DOX\uff09\uff0c\u6807\u5c3a\u4e3a50 \u03bcm\u3002<\/p>\n<p><strong>\u56fe7. 4T1\u8377\u7624\u5c0f\u9f20\u5149\u70ed\u6cbb\u7597\u8fc7\u7a0b\u53ca\u80bf\u7624\u5207\u7247\u75c5\u7406\u5206\u6790<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-146165\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/07\/figure-7.jpg\" alt=\"\" width=\"585\" height=\"600\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/07\/figure-7.jpg 585w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/07\/figure-7-293x300.jpg 293w\" sizes=\"(max-width: 585px) 100vw, 585px\" \/><\/p>\n<p>(A) 4T1\u539f\u4f4d\u7624\u5c0f\u9f20\u5c3e\u9759\u8109\u6ce8\u5c04\u751f\u7406\u76d0\u6c34\u3001CuSNDs \u548cTSNCs \u540e24 \u5c0f\u65f6\u7ed9\u4e88808 nm \u8fd1\u7ea2\u5916\u6fc0\u5149\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u968f\u65f6\u95f4\u53d8\u5316\u7684\u7ea2\u5916\u70ed\u50cf\u56fe\uff1b<\/p>\n<p>(B) \u8fd1\u7ea2\u5916\u6fc0\u5149\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u5404\u7ec4\u80bf\u7624\u968f\u65f6\u95f4\u53d8\u5316\u7684\u6e29\u5ea6\u66f2\u7ebf\u56fe\uff1b<\/p>\n<p>(C) Control\u3001Laser\u3001CuSNDs\u3001TSNCs\u3001DOX\u3001CuSNDs + laser \u548cTSNCs + laser \u5404\u7ec4\u5904\u7406\u56e0\u7d20\u6cbb\u7597\u540e4\u5c0f\u65f6\uff0c4T1\u539f\u4f4d\u80bf\u7624\u7ec4\u7ec7\u5207\u7247\u7684H&amp;E\u3001TUNEL\u3001Ki-67\u548cHSP70\u514d\u75ab\u7ec4\u5316\u67d3\u8272\uff0c\u6807\u5c3a= 50 \u03bcm\u3002<\/p>\n<p><strong>\u56fe8. 4T1\u8377\u7624\u5c0f\u9f20\u5149\u70ed\u6cbb\u7597\u6548\u679c\u8bc4\u4ef7<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-146166\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/07\/figure-8.jpg\" alt=\"\" width=\"600\" height=\"458\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/07\/figure-8.jpg 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/07\/figure-8-300x229.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>(A) \u5c0f\u9f20\u6765\u6e90\u4e73\u817a\u764c4T1 \u539f\u4f4d\u7624\u5c0f\u9f20\u7ecf\u8fc7Control\u3001Laser\u3001CuSNDs\u3001TSNCs\u3001DOX\u3001CuSNDs + laser \u548cTSNCs + laser \u6cbb\u7597\u540e\uff0c\u80bf\u7624\u5927\u5c0f\u968f\u65f6\u95f4\u53d8\u5316\u7684\u80bf\u7624\u751f\u957f\u66f2\u7ebf\uff08* <em>P<\/em> &lt; 0.05,*** <em>P <\/em>&lt; 0.001\uff09\uff1b<\/p>\n<p>(B) \u4e73\u817a\u764c4T1\u539f\u4f4d\u7624\u5c0f\u9f20\u7ecf\u8fc7Control\u3001Laser\u3001CuSNDs\u3001TSNCs\u3001DOX\u3001CuSNDs + laser \u548cTSNCs + laser \u6cbb\u7597\u540e\u89e3\u5256\u6240\u5f97\u80bf\u7624\u7167\u7247\uff1b<\/p>\n<p>(C) \u4e73\u817a\u764c4T1 \u539f\u4f4d\u7624\u5c0f\u9f20\u7ecf\u8fc7Control\u3001Laser\u3001CuSNDs\u3001TSNCs\u3001DOX\u3001CuSNDs + laser \u548cTSNCs + laser \u6cbb\u7597\u540e\u89e3\u5256\u6240\u5f97\u80bf\u7624\u91cd\u91cf\uff08***<em> P<\/em> &lt; 0.001\uff09\u3002<\/p>\n<p><strong>\u56fe9. 4T1\u8377\u7624\u5c0f\u9f20\u5149\u70ed\u6cbb\u7597\u540e\u80ba\u8f6c\u79fb\u60c5\u51b5\u53ca\u809d\u810fH&amp;E\u67d3\u8272<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-146167\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/07\/figure-9.jpg\" alt=\"\" width=\"600\" height=\"409\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/07\/figure-9.jpg 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/07\/figure-9-300x205.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>(A) \u5c0f\u9f20\u6765\u6e90\u4e73\u817a\u764c4T1 \u539f\u4f4d\u7624\u5c0f\u9f20\u7ecf\u8fc7Control\u3001Laser\u3001CuSNDs\u3001TSNCs\u3001DOX\u3001CuSNDs + laser \u548cTSNCs + laser\u6cbb\u7597\u540e\u80ba\u8f6c\u79fb\u60c5\u51b5\uff1b<\/p>\n<p>(B) \u4e73\u817a\u764c4T1 \u539f\u4f4d\u7624\u5c0f\u9f20\u7ecf\u8fc7Control\u3001Laser\u3001CuSNDs\u3001TSNCs\u3001DOX\u3001CuSNDs + laser \u548cTSNCs + laser \u6cbb\u7597\u540e\u809d\u810fH&amp;E\u67d3\u8272\u3002<\/p>\n<p><strong>\u56fe10. \u4e0d\u540c\u5904\u7406\u56e0\u7d20\u5904\u74064T1\u7ec6\u80de\u540e\u6b8b\u7559\u5e72\u7ec6\u80de\u6210\u7403\u60c5\u51b5<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-146168\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/07\/figure-10.jpg\" alt=\"\" width=\"498\" height=\"600\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/07\/figure-10.jpg 498w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/07\/figure-10-249x300.jpg 249w\" sizes=\"(max-width: 498px) 100vw, 498px\" \/><\/p>\n<p>(A) \u5c0f\u9f20\u6765\u6e90\u4e73\u817a\u764c 4T1 \u7ec6\u80deControl\u3001Laser\u3001CuSNDs\u3001TSNCs\u3001DOX\u3001CuSNDs + laser\u548cTSNCs + laser\u5904\u7406\u540e\u6b8b\u7559\u5e72\u7ec6\u80de\u6210\u7403\u60c5\u51b5\uff1b<\/p>\n<p>(B) \u5404\u7ec4\u80bf\u7624\u5e72\u7ec6\u80de\u7403\u6570\u91cf\u5b9a\u91cf\u7ed3\u679c\uff08***<em> P <\/em>&lt; 0.001\uff09\u3002<\/p>\n<p><strong>\u56fe11. \u4e0d\u540c\u5904\u7406\u56e0\u7d20\u5bf94T1\u8377\u7624\u5c0f\u9f20\u5fc3\u810f\u6bd2\u6027\u5f71\u54cd\u7684\u8bc4\u4ef7<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-146169\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/07\/figure-11.jpg\" alt=\"\" width=\"471\" height=\"600\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/07\/figure-11.jpg 471w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/07\/figure-11-236x300.jpg 236w\" sizes=\"(max-width: 471px) 100vw, 471px\" \/><\/p>\n<p>(A) \u5c0f\u9f20\u6765\u6e90\u4e73\u817a\u764c 4T1 \u7ec6\u80deControl\u3001DOX\u548cTSNCs + laser\u6cbb\u7597\u540e\u5fc3\u52a8\u8d85\u58f0\u56fe\uff1b<\/p>\n<p>(B) \u5404\u7ec4\u5c0f\u9f20\u5de6\u5fc3\u5c04\u8840\u5206\u6570\u503c\uff1b<\/p>\n<p>(C) \u5404\u7ec4\u5c0f\u9f20\u5de6\u5fc3\u6536\u7f29\u5206\u6570\u503c\uff1b<\/p>\n<p>(D) \u5404\u7ec4\u5c0f\u9f20\u5fc3\u810fH&amp;E\u67d3\u8272\u7ed3\u679c\uff08** <em>P<\/em> &lt; 0.01\uff09\u3002<\/p>\n<p><strong>\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n<p>TSNCs \u591a\u529f\u80fd\u7eb3\u7c73\u8f7d\u836f\u7cfb\u7edf\u5177\u6709\u826f\u597d\u7684EPR \u6548\u5e94\uff0c\u53ef\u4ee5\u88ab\u52a8\u9776\u5411\u5bcc\u96c6\u81f3\u80bf\u7624\uff0c\u5728808 nm \u8fd1\u7ea2\u5916\u6fc0\u5149\u7167\u5c04\u4e0b\uff0cTSNCs \u53ef\u4ee5\u5b9e\u73b0\u80bf\u7624\u5185\u90e8\u8840\u7ba1\u7a00\u5c11\u548c\u4e4f\u6c27\u533a\u57df\u7684\u9ad8\u6e17\u900f\u6027\u3002TSNCs \u8054\u5408\u8fd1\u7ea2\u5916\u6fc0\u5149\u7167\u5c04\u6240\u4ea7\u751f\u7684\u5149\u70ed-\u5316\u7597\u534f\u540c\u4f5c\u7528\u53ef\u4ee5\u663e\u8457\u7684\u6291\u5236\u80bf\u7624\u7684\u751f\u957f\u548c\u8fdc\u5904\u8f6c\u79fb\u3002TSNCs\u53ef\u4ee5\u907f\u514d\u6e38\u79bbDOX \u4ea7\u751f\u7684\u5fc3\u810f\u6bd2\u6027\uff0c\u65e0\u660e\u663e\u7cfb\u7edf\u6027\u6bd2\u6027\u4ea7\u751f\u3002<\/p>\n<p><strong>\u00a0<\/strong><strong>\u6587\u732e\u94fe\u63a5\uff1a<\/strong><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/adfm.201801738\"><strong>https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/adfm.201801738<\/strong><\/a> <strong>(Adv. Funct. Mater., 2018, <\/strong><strong>DOI: 10.1002\/adfm.201801738<\/strong><strong>)<\/strong><\/p>\n<p><strong>\u3010\u901a\u8baf\u4f5c\u8005\u53ca\u56e2\u961f\u7b80\u4ecb\u3011<\/strong><\/p>\n<p>\u5468\u6c11\u6559\u6388\uff1a\u201c\u56fd\u5bb6\u9752\u5e74\u5343\u4eba\u8ba1\u5212\u201d\u548c\u6d59\u6c5f\u5927\u5b66\u201c\u767e\u4eba\u8ba1\u5212\u201d\u5165\u9009\u8005\uff0c\u5e76\u62c5\u4efb\u6559\u80b2\u90e8\u6076\u6027\u80bf\u7624\u9884\u8b66\u4e0e\u5e72\u9884\u91cd\u70b9\u5b9e\u9a8c\u5ba4\u526f\u4e3b\u4efb\u3002\u81ea2016\u5e74\u56de\u56fd\u4ee5\u6765\uff0c\u5468\u6c11\u7814\u7a76\u5458\u53ca\u5176\u5e26\u9886\u7684\u7814\u7a76\u56e2\u961f\u5145\u5206\u5229\u7528\u6211\u6821\u5b66\u79d1\u95e8\u7c7b\u9f50\u5168\u3001\u5b66\u79d1\u7ed3\u6784\u5c42\u6b21\u4e30\u5bcc\u3001\u4ea4\u53c9\u5b66\u79d1\u5e73\u53f0\u96c6\u805a\u7b49\u5b66\u79d1\u751f\u6001\u591a\u6837\u5316\u7684\u4f18\u52bf\uff0c\u4e3b\u8981\u56f4\u7ed5\u201c\u5206\u5b50\u5f71\u50cf\u548c\u7eb3\u7c73\u533b\u5b66\u201d\u5728\u764c\u75c7\u8bca\u65ad\u53ca\u6cbb\u7597\u4e2d\u7684\u5e94\u7528\u8fd9\u4e00\u56fd\u9645\u7814\u7a76\u70ed\u70b9\uff0c\u81f4\u529b\u4e8e\u65b0\u578b\u7eb3\u7c73\u836f\u7269\u7684\u7814\u53d1\uff0c\u53d6\u5f97\u4e86\u4e00\u7cfb\u5217\u521b\u65b0\u6027\u5e76\u5177\u6709\u8f83\u9ad8\u4e34\u5e8a\u8f6c\u5316\u524d\u666f\u7684\u91cd\u8981\u7814\u7a76\u6210\u679c\uff0c\u6574\u4e2a\u56e2\u961f\u8fd1\u5e74\u6765\u5df2\u7ecf\u53d1\u8868\u4e86\u4e00\u7cfb\u5217\u9ad8\u6c34\u5e73\u5b66\u672f\u8bba\u6587\uff08Adv. Funct. Mater. 2018, 28, 1801738, \u00a0Adv. Funct. Mater. 2018, 28, 1704634, \u00a0ACS Appl. Mater. Interfaces 2018, 10, 193, \u00a0J. Nucl. 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