{"id":146676,"date":"2018-07-23T14:00:51","date_gmt":"2018-07-23T06:00:51","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=146676"},"modified":"2018-07-23T09:49:00","modified_gmt":"2018-07-23T01:49:00","slug":"%e6%b5%99%e6%b1%9f%e5%a4%a7%e5%ad%a6adv-mater-%ef%bc%9a%e4%b8%8a%e8%bd%ac%e6%8d%a2%e7%ba%b3%e7%b1%b3%e7%b2%92%e5%ad%90%e7%9a%84%e5%93%8d%e5%ba%94%e6%80%a7%e7%bb%84%e8%a3%85%e7%94%a8%e4%ba%8eph","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=146676","title":{"rendered":"\u6d59\u6c5f\u5927\u5b66Adv. Mater.\uff1a\u4e0a\u8f6c\u6362\u7eb3\u7c73\u7c92\u5b50\u7684\u54cd\u5e94\u6027\u7ec4\u88c5\u7528\u4e8epH\u6fc0\u6d3b\u548c\u8fd1\u7ea2\u5916\u89e6\u53d1\u7684\u6df1\u5ea6\u80bf\u7624\u5149\u52a8\u529b\u6cbb\u7597"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n

\u5149\u52a8\u529b\u6cbb\u7597\u56e0\u5176\u5fae\u521b\u800c\u4e14\u5177\u6709\u65f6\u7a7a\u63a7\u5236\u6cbb\u7597\u80fd\u529b\uff0c\u5df2\u7ecf\u5e7f\u6cdb\u5e94\u7528\u4e8e\u80bf\u7624\u6cbb\u7597\u3002\u8fd1\u5e74\u6765\uff0c\u9567\u7cfb\u5143\u7d20\u63ba\u6742\u7684\u4e0a\u8f6c\u6362\u7eb3\u7c73\u7c92\u5b50\u5df2\u7ecf\u53ef\u4ee5\u7528\u4f5c\u7eb3\u7c73\u4f20\u5bfc\u5668\u5b9e\u73b0\u4f53\u5185\u6df1\u5c42\u7ec4\u7ec7\u7684\u5149\u52a8\u529b\u6cbb\u7597\uff0c\u4f46\u662f\u8fd9\u79cd\u5149\u52a8\u529b\u6cbb\u7597\u5242\u5177\u6709\u660e\u663e\u7684\u526f\u4f5c\u7528\u3002\u4e3a\u4e86\u964d\u4f4e\u60a3\u8005\u7684\u8d1f\u62c5\uff0cpH \u503c\u3001\u8c37\u80f1\u7518\u80bd\u548c\u9176\u7b49\u591a\u79cd\u54cd\u5e94\u7684\u5149\u654f\u5242\u88ab\u5f00\u53d1\u51fa\u6765\u3002\u5c3d\u7ba1\u8fd9\u4e9b\u6cbb\u7597\u4f53\u7cfb\u4f9d\u7136\u8981\u6d89\u53ca\u53ef\u89c1\u5149\u7684\u4f7f\u7528\uff0c\u5149\u52a8\u529b\u6cbb\u7597\u7684\u5b89\u5168\u6027\u5df2\u7ecf\u5f97\u5230\u8f83\u5927\u7684\u63d0\u9ad8\u3002\u7136\u800c\uff0c\u622a\u6b62\u76ee\u524d\uff0c\u4ec5\u5728\u80bf\u7624\u5904\u6fc0\u6d3b\u800c\u4e14\u4f7f\u7528\u7ea2\u5916\u5149\u5c31\u53ef\u4ee5\u51fa\u53d1\u7684\u5149\u52a8\u529b\u6cbb\u7597\u5242\u8fd8\u6ca1\u6709\u76f8\u5173\u62a5\u9053\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u6d59\u6c5f\u5927\u5b66\u51cc\u4ee3\u821c\u6559\u6388<\/strong>\u8bfe\u9898\u7ec4\u53d1\u5c55\u4e86\u4e00\u79cd\u80bf\u7624pH\u654f\u611f\u7684\u5149\u52a8\u529b\u7eb3\u7c73\u6cbb\u7597\u5242\uff0c\u8be5\u6cbb\u7597\u5242\u80fd\u591fpH 7.4\uff08\u6b63\u5e38\u8840\u6db2\uff09\u548c6.5\uff08\u7ec6\u80de\u5916\u80bf\u7624\uff09\u4e4b\u95f4\u53d1\u751f\u7ec4\u88c5\u7ed3\u6784\u7684\u6539\u53d8\u5e76\u4e14\u89e3\u79bb\u51fa\u5149\u654f\u5242\uff0c\u8fdb\u800c\u5728\u8fd1\u7ea2\u5916\u5149\u7684\u7167\u5c04\u6761\u4ef6\u4e0b\u4e0a\u8f6c\u6362\u7eb3\u7c73\u7c92\u5b50\u80fd\u591f\u6fc0\u53d1\u5149\u654f\u5242\u3002\u6b64\u5916\uff0c\u5149\u52a8\u529b\u6cbb\u7597\u5242\u7684\u4e0a\u8f6c\u6362\u53d1\u5149\u8fd8\u53ef\u4ee5\u7528\u4e8e\u6210\u50cf\u5f15\u5bfc\u7684\u5149\u52a8\u529b\u6cbb\u7597\u3002\u8be5\u6210\u679c\u4ee5\u9898\u4e3a”Responsive Assembly of Upconversion Nanoparticles for pH-Activated and Near-Infrared-Triggered Photodynamic Therapy of Deep Tumors”<\/strong>\u53d1\u8868\u5728Advanced Materials<\/strong>\u4e0a\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe<\/strong>1 <\/strong>\u80bf\u7624<\/strong>pH<\/strong>\u6fc0\u6d3b\u5149\u52a8\u529b\u7eb3\u7c73\u6cbb\u7597\u5242\u7684\u8bbe\u8ba1\u793a\u610f\u56fe\u548c\u673a\u5236<\/strong><\/p>\n

\"\"<\/p>\n

(a) \u4e0a\u8f6c\u6362\u7eb3\u7c73\u7c92\u5b50\u7684pH\u54cd\u5e94\u3001\u914d\u4f53\u8f85\u52a9\u7ec4\u88c5\u7684\u793a\u610f\u56fe\uff1b<\/p>\n

(b) \u80bf\u7624Ph\u54cd\u5e94\u7684\u6df1\u5c42\u7ec4\u7ec7\u5149\u52a8\u529b\u6cbb\u7597\u793a\u610f\u56fe\u3002<\/p>\n

\u56fe2 \u5149\u52a8\u529b\u7eb3\u7c73\u6cbb\u7597\u5242\u7684\u8868\u5f81<\/strong><\/p>\n

\"\"<\/p>\n

(a) \u5149\u52a8\u529b\u7eb3\u7c73\u6cbb\u7597\u5242\u5728pH 7.4\u6761\u4ef6\u4e0b\u7684TEM\u56fe\u7247\uff1b<\/p>\n

(b) \u5149\u52a8\u529b\u7eb3\u7c73\u6cbb\u7597\u5242\u5728pH 5.5\u6761\u4ef6\u4e0b\u7684TEM\u56fe\u7247\uff1b<\/p>\n

(c) \u4e0d\u540cpH\u503c\u6761\u4ef6\u4e0b\u5149\u52a8\u529b\u7eb3\u7c73\u6cbb\u7597\u5242zeta\u7535\u4f4d\u7684\u53d8\u5316\uff1b<\/p>\n

(d) \u4e0d\u540cpH\u503c\u6761\u4ef6\u4e0b\u5149\u52a8\u529b\u7eb3\u7c73\u6cbb\u7597\u5242\u7684\u7c92\u5b50\u5c3a\u5bf8\u5206\u5e03\uff1b<\/p>\n

(e) \u4e0d\u540cpH\u503c\u6761\u4ef6\u4e0b\u5149\u52a8\u529b\u7eb3\u7c73\u6cbb\u7597\u5242\u7684\u8367\u5149\u5f3a\u5ea6\uff1b<\/p>\n

(f) \u4e0d\u540cpH\u503c\u6761\u4ef6\u4e0b\u5149\u52a8\u529b\u7eb3\u7c73\u6cbb\u7597\u5242\u6eb6\u6db2\u900f\u8fc7\u7387\u7684\u53d8\u5316\uff1b<\/p>\n

(g) Ce6\u548c\u4e0a\u8f6c\u6362\u7eb3\u7c73\u7c92\u5b50\u7684\u4e0a\u8f6c\u6362\u53d1\u5149\u8c31\u56fe\uff1b<\/p>\n

(h) \u5149\u52a8\u529b\u7eb3\u7c73\u6cbb\u7597\u5242\u5728980\u7eb3\u7c73\u6fc0\u5149\u7167\u5c04\u4e0d\u540c\u65f6\u95f4\u540e\u5bf91,3-\u4e8c\u82ef\u57fa\u5f02\u82ef\u5e76\u544b\u5583\u5438\u6536\u5149\u8c31\u7684\u5f71\u54cd\uff1b<\/p>\n

(i) 1,3-\u4e8c\u82ef\u57fa\u5f02\u82ef\u5e76\u544b\u5583\u5728\u5149\u52a8\u529b\u7eb3\u7c73\u6cbb\u7597\u5242\u6216pH\u54cd\u5e94\u805a\u5408\u7269\u914d\u4f53\u5b58\u5728\u6761\u4ef6\u4e0b \u5bf9pH\u503c\u4f9d\u8d56\u7684\u5438\u6536\u60c5\u51b5\u3002<\/p>\n

\u56fe3 \u5149\u52a8\u529b<\/strong>\u7eb3\u7c73<\/strong>\u6cbb\u7597\u5242\u4e0e\u7ec6\u80de\u95f4\u4f53\u5916pH\u4f9d\u8d56\u7684\u76f8\u4e92\u4f5c\u7528<\/strong><\/p>\n

\"\"<\/p>\n

(a) pH 6.5\u6761\u4ef6\u4e0b\u901a\u8fc7\u5171\u805a\u7126\u6fc0\u5149\u626b\u63cf\u663e\u5fae\u955c\u7814\u7a76\u5149\u52a8\u529b\u7eb3\u7c73\u6cbb\u7597\u5242(PPNs)\u548cpH\u4e0d\u654f\u611f\u7684\u5149\u52a8\u529b\u7eb3\u7c73\u8bd5\u5242(PIPNs)\u7684\u7ec6\u80de\u6444\u53d6\u60c5\u51b5\uff1b<\/p>\n

(b) PIPNs \u5728pH 6.5\u62167.4\u4e14\u65e0980\u7eb3\u7c73\u6fc0\u5149\u7167\u5c04\u6761\u4ef6\u4e0b\u7684A549\u7ec6\u80de\u7684CCK-8\u6d4b\u5b9a\uff1b<\/p>\n

(c) PIPNs \u5728pH 6.5\u62167.4\u4e14\u6709980\u7eb3\u7c73\u6fc0\u5149\u7167\u5c04\u6761\u4ef6\u4e0b\u7684A549\u7ec6\u80de\u7684CCK-8\u6d4b\u5b9a\uff1b<\/p>\n

(d) PPNs \u5728pH 6.5\u62167.4\u4e14\u65e0980\u7eb3\u7c73\u6fc0\u5149\u7167\u5c04\u6761\u4ef6\u4e0b\u7684A549\u7ec6\u80de\u7684CCK-8\u6d4b\u5b9a\uff1b<\/p>\n

(e) PPNs \u5728pH 6.5\u62167.4\u4e14\u6709980\u7eb3\u7c73\u6fc0\u5149\u7167\u5c04\u6761\u4ef6\u4e0b\u7684A549\u7ec6\u80de\u7684CCK-8\u6d4b\u5b9a\u3002<\/p>\n

\u56fe4 \u4e0a\u8f6c\u6362\u53d1\u5149\u6210\u50cf\u5f15\u5bfc\u7684\u4f53\u5185\u5149\u52a8\u529b\u6cbb\u7597<\/strong><\/p>\n

\"\"<\/p>\n

(a) \u6ce8\u5c04\u5149\u52a8\u529b\u7eb3\u7c73\u6cbb\u7597\u5242\u7684\u5c0f\u9f20\u4f53\u5185\u4e0a\u8f6c\u6362\u53d1\u5149\u56fe\u7247\uff1b<\/p>\n

(b) \u6cbb\u7597\u4e2d\u7279\u5b9a\u7ec4\u5c0f\u9f20\u7684\u76f8\u5bf9\u80bf\u7624\u4f53\u79ef\u53d8\u5316\uff1b<\/p>\n

(c) \u6cbb\u7597\u4e2d\u7279\u5b9a\u7ec4\u5c0f\u9f20\u7684\u4f53\u91cd\u53d8\u5316\uff1b<\/p>\n

(d) \u5728\u5149\u52a8\u529b\u6cbb\u759714\u5929\u540e\u4e0d\u540c\u7ec4\u5c0f\u9f20\u6536\u96c6\u7684\u80bf\u7624\u5207\u7247\u7684\u5178\u578bH&E\u3001TUNEL\u3001Ki67\u548c CD31\u67d3\u8272\u56fe\u7247\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

\u672c\u6587\u62a5\u9053\u4e86\u4e00\u79cdpH\u6fc0\u6d3b\u3001\u8fd1\u7ea2\u5916\u5149\u89e6\u53d1\u7684\u5149\u52a8\u529b\u5b66\u6cbb\u7597\u4f53\u7cfb\uff0c\u5728\u8f7b\u5ea6\u9178\u6027\u80bf\u7624\u5fae\u73af\u5883\u4e2d\uff0c\u8be5\u79cd\u5149\u52a8\u529b\u5b66\u6cbb\u7597\u5242\u80fd\u591f\u89e3\u79bb\u4ece\u800c\u4fc3\u8fdb\u5149\u654f\u5242\u7684\u5149\u6d3b\u5316\u8fc7\u7a0b\u3002\u4f53\u5916\u548c\u4f53\u5185\u5b9e\u9a8c\u7ed3\u679c\u5747\u8868\u660e\u8be5\u79cd\u5149\u52a8\u529b\u5b66\u6cbb\u7597\u5242\u53ef\u4ee5\u514b\u670d\u5e38\u89c4\u6cbb\u7597\u5242\u7684\u4e00\u4e9b\u5f0a\u7aef\uff0c\u8bf8\u5982\u7ec4\u7ec7\u6e17\u900f\u6df1\u5ea6\u6709\u9650\u3001\u80bf\u7624\u7ec6\u80de\u9776\u5411\u80fd\u529b\u4e0d\u8db3\u548c\u663e\u8457\u7684\u526f\u4f5c\u7528\u7b49\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aResponsive Assembly of Upconversion Nanoparticles for pH-Activated and Near-Infrared-Triggered Photodynamic Therapy of Deep Tumors\u00a0<\/a>\u00a0\u00a0(Adv. Mater. 2018, DOI: 10.1002\/adma.201802808)<\/strong><\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u9ad8\u5206\u5b50\u548c\u751f\u7269\u5b66\u672f\u7ec4Gaxy\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u5ba1\u6838\u6574\u7406\u3002<\/p>\n

\u6750\u6599\u725b\u7f51\u7ad9\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u53ca\u884c\u4e1a\u4ece\u4e1a\u5458\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c\u70b9\u6211\u52a0\u5165\u6750\u6599\u4eba\u7f16\u8f91\u90e8<\/a>\u3002<\/p>\n

\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1tougao@cailiaoren.com\u3002<\/p>\n

\u6295\u7a3f\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1acailiaorenkefu\u3002<\/p>\n

\u6750\u6599\u6d4b\u8bd5\u3001\u6570\u636e\u5206\u6790\uff0c<\/strong>\u4e0a<\/strong><\/a>\u6d4b\u8bd5\u8c37<\/strong><\/a>\uff01<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

\u3010\u5f15\u8a00\u3011 \u5149\u52a8\u529b\u6cbb\u7597\u56e0\u5176\u5fae\u521b\u800c\u4e14\u5177\u6709\u65f6\u7a7a\u63a7\u5236\u6cbb\u7597\u80fd\u529b\uff0c\u5df2\u7ecf\u5e7f\u6cdb\u5e94\u7528\u4e8e\u80bf\u7624\u6cbb\u7597\u3002\u8fd1\u5e74\u6765\uff0c\u9567\u7cfb\u5143\u7d20\u63ba\u6742\u7684\u4e0a\u8f6c\u6362\u7eb3\u7c73\u7c92\u5b50\u5df2\u7ecf\u53ef\u4ee5\u7528\u4f5c\u7eb3\u7c73\u4f20\u5bfc\u5668\u5b9e\u73b0\u4f53\u5185\u6df1\u5c42\u7ec4\u7ec7\u7684\u5149\u52a8\u529b…<\/p>\n","protected":false},"author":7746,"featured_media":146681,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215],"tags":[3423,3424,3425],"class_list":["post-146676","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-jiedu","tag-3423","tag-3424","tag-3425"],"_links":{"self":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/146676"}],"collection":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/users\/7746"}],"replies":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=146676"}],"version-history":[{"count":4,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/146676\/revisions"}],"predecessor-version":[{"id":147294,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/146676\/revisions\/147294"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/media\/146681"}],"wp:attachment":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=146676"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=146676"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=146676"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}