{"id":147253,"date":"2018-07-26T14:00:53","date_gmt":"2018-07-26T06:00:53","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=147253"},"modified":"2018-07-23T10:08:22","modified_gmt":"2018-07-23T02:08:22","slug":"%e8%91%a3%e6%96%87%e9%a3%9e-kam-w-leong-adv-mater-%e4%bb%bf%e7%94%9f%e7%9a%84%e8%81%94%e7%a1%92%e5%8c%96%e7%89%a9%e6%a1%a5%e6%8e%a5%e4%bb%8b%e5%ad%94%e4%ba%8c%e6%b0%a7%e5%8c%96%e7%a1%85","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=147253","title":{"rendered":"\u8463\u6587\u98de& Kam W. Leong Adv. Mater.: \u4eff\u751f\u7684\u8054\u7852\u5316\u7269\u6865\u63a5\u4ecb\u5b54\u4e8c\u6c27\u5316\u7845\u7eb3\u7c73\u9897\u7c92\u7528\u4e8e\u53cc\u54cd\u5e94\u86cb\u767d\u9012\u9001"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n

\u4ecb\u5b54\u4e8c\u6c27\u5316\u7845\u7eb3\u7c73\u9897\u7c92\uff08MSNs\uff09\u7531\u4e8e\u5176\u53ef\u8c03\u8282\u7684\u5b54\u5f84\u3001\u5f62\u6001\u548c\u8868\u9762\u5b98\u80fd\u5316\u800c\u5728\u836f\u7269\u9012\u9001\u4e2d\u53d7\u5230\u76f8\u5f53\u5927\u7684\u5173\u6ce8\uff0c\u4f46\u662f\u7eaf\u65e0\u673a\u9aa8\u67b6\u7684\u7f13\u6162\u751f\u7269\u964d\u89e3\u6027\u9650\u5236\u4e86\u5b83\u4eec\u7684\u5e94\u7528\uff0c\u7279\u522b\u662f\u4f18\u9009\u57fa\u8d28\u964d\u89e3\u7684\u63a7\u91ca\u673a\u5236\u3002\u6709\u673a\u6865\u63a5\u7684MSNs\u53ef\u4ee5\u5728\u5206\u5b50\u6c34\u5e73\u4e0a\u5c06\u529f\u80fd\u6027\u6709\u673a\u4e8c\u6c27\u5316\u7845\u90e8\u5206\u7ed3\u5408\u5230\u4ecb\u5b54\u4e8c\u6c27\u5316\u7845\u9aa8\u67b6\u4e2d\u6765\u89e3\u51b3\u8be5\u7f3a\u70b9\u3002\u5176\u4e2d\u86cb\u767d\u8d28\u6cbb\u7597\u5242\u662f\u5728\u5206\u5b50\u6c34\u5e73\u4e0a\u5e72\u9884\u7684\u6700\u6709\u6548\u836f\u7269\u4e4b\u4e00, \u4f46\u5b83\u6613\u53d7\u86cb\u767d\u9176\u964d\u89e3\u548c\u53d8\u6027\u7684\u5f71\u54cd\u3002\u4e3a\u4e86\u589e\u5f3a\u751f\u7269\u964d\u89e3\u548c\u6539\u5584\u6709\u673a\u6865\u8054MSNs\u7684\u6309\u9700\u86cb\u767d\u8d28\u91ca\u653e\uff0c\u901a\u8fc7\u8fdb\u4e00\u6b65\u5c06\u5176\u4ed6\u5143\u7d20\u7eb3\u5165\u7528\u4e8e\u86cb\u767d\u8d28\u9012\u9001\u7684\u4ecb\u5b54\u4e8c\u6c27\u5316\u7845\u6846\u67b6\u4e2d\u6269\u5c55\u5176\u73af\u5883\u54cd\u5e94\u6027\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u4e2d\u56fd\u79d1\u5b66\u9662\u82cf\u5dde\u751f\u7269\u533b\u5b66\u5de5\u7a0b\u6280\u672f\u7814\u7a76\u6240\u7684\u8463\u6587\u98de\u548c\u7f8e\u56fd\u54e5\u4f26\u6bd4\u4e9a\u5927\u5b66\u7684Kam W. Leong\u6559\u6388\uff08\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u7b49\u62a5\u9053\u4e86\u5c06\u542b\u4e8c\u7852\u5316\u7269\u6865\u8054\u7684\u6709\u673a\u4e8c\u6c27\u5316\u7845\u90e8\u5206\u5305\u542b\u5728\u4e8c\u6c27\u5316\u7845\u9aa8\u67b6\u4e2d\u4ee5\u5236\u5907\u5177\u6709\u6c27\u5316\u548c\u6c27\u5316\u8fd8\u539f\u53cc\u54cd\u5e94\u6027\u7684\u53ef\u751f\u7269\u964d\u89e3\u7684\u4e2d\u5b54\u4e8c\u6c27\u5316\u7845\u7eb3\u7c73\u9897\u7c92\uff08MSNs\uff09\u3002\u8fd9\u4e9b\u4e8c\u7852\u5316\u7269\u6865\u63a5\u7684MSNs\u901a\u8fc7\u9759\u7535\u76f8\u4e92\u4f5c\u7528\u5c06\u5177\u6709\u7ec6\u80de\u6bd2\u6027RNase A\u5305\u5c01\u52308-10 nm\u7684\u5185\u90e8\u5b54\u4e2d\uff0c\u5e76\u5728\u6c27\u5316\u6216\u6c27\u5316\u8fd8\u539f\u6761\u4ef6\u4e0b\u901a\u8fc7\u57fa\u8d28\u964d\u89e3\u91ca\u653e\u8d1f\u8f7d\u7684\u836f\u7269\u3002\u7528\u764c\u7ec6\u80de\u884d\u751f\u7684\u819c\u7247\u6bb5\u4fee\u9970\u8868\u9762\u540e\uff0cMSNs\u8d1f\u8f7d\u7684RNase A\u8868\u73b0\u51fa\u81ea\u6e90\u764c\u7ec6\u80de\u7684\u540c\u6e90\u9776\u5411\u6027\u548c\u514d\u75ab\u4fb5\u88ad\u6027\u7684\u7279\u5f81\u3002\u7ec6\u80de\u819c\u5305\u88ab\u7684\u5177\u6709\u53cc\u54cd\u5e94\u6027\u53ef\u964d\u89e3\u7684MSNs\u5177\u6709\u826f\u597d\u7684\u4f53\u5916\u548c\u4f53\u5185\u6297\u764c\u6027\u80fd\u5305\u62ec\u589e\u52a0\u8840\u6db2\u5faa\u73af\u65f6\u95f4\u548c\u589e\u5f3a\u5728\u80bf\u7624\u5904\u7684\u7d2f\u79ef\u4ee5\u53ca\u4f4e\u6bd2\u6027\u3002\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a\u201cBioinspired Diselenide-Bridged Mesoporous Silica Nanoparticles for Dual-Responsive Protein Delivery\u201d<\/strong>\u53d1\u5e03\u5728\u56fd\u9645\u8457\u540d\u671f\u520aAdv. Mater.<\/strong>\u4e0a\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe\u4e00\u3001\u4e8c\u7852\u5316\u7269\u6865\u8054MSNs\u7684\u5236\u5907\u793a\u610f\u56fe\u548c\u53cc\u54cd\u5e94<\/strong><\/p>\n

\"\"<\/strong><\/p>\n

\u00a0\u56fe\u4e8c\u3001\u4e8c\u7852\u5316\u7269\u6865\u8054MSNs\u7684\u7406\u5316\u8868\u5f81\u00a0<\/strong><\/p>\n

\"\"<\/strong><\/p>\n

\uff08a\uff09 BTESePD\u76841<\/sup>H NMR\uff1b<\/p>\n

\uff08b\uff09 BTESePD\u7684MS\uff1b<\/p>\n

\uff08c\uff09 MSN0 (S-S, 4:1)\u7684TEM\u56fe\u548c3D\u6a21\u578b\u56fe\uff1b<\/p>\n

\uff08d\uff09 MSN1 (Se-Se, 4:1) \u7684TEM\u56fe\u548c3D\u6a21\u578b\u56fe\uff1b<\/p>\n

\uff08e\uff09 MSN2 (Se-Se, 3:2) \u7684TEM\u56fe\u548c3D\u6a21\u578b\u56fe\u3002<\/p>\n

\u56fe\u4e09\u3001\u4e8c\u7852\u6865\u8054MSNs\u7684\u53cc\u54cd\u5e94\u964d\u89e3\u548c\u86cb\u767d\u8d28\u91ca\u653e\u00a0<\/strong><\/p>\n

\"\"<\/strong><\/p>\n

\uff08a\uff09 \u4e0d\u540c\u964d\u89e3\u95f4\u9694\u4e0b5\u00d710-3<\/sup> M GSH\u6216100\u00d710 -6<\/sup> M H2<\/sub>O2<\/sub>\u4e0bMSNs\u7684TEM\u56fe\uff1b<\/p>\n

\uff08b\uff09 MSNs @ RNase A\u57285\u00d710-3<\/sup> M GSH\u3001100\u00d710 -6<\/sup> M H2<\/sub>O2<\/sub>\u6216\u6c34\u4e2d48 h\u7684\u836f\u7269\u91ca\u653e\u66f2\u7ebf\u3002<\/p>\n

\u56fe\u56db\u3001\u764c\u7ec6\u80de\u819c\u4fee\u9970\u7684MSNs @ RNase A\u7684\u5236\u5907\u00a0<\/strong><\/p>\n

\"\"<\/strong><\/p>\n

\uff08a\uff09 MSN0@RNase A@CM\u7684TEM\u56fe\uff1b<\/p>\n

\uff08b\uff09 MSN1@RNase A@CM\u7684TEM\u56fe\uff1b<\/p>\n

\uff08c\uff09 MSN2@RNase A@CM\u7684TEM\u56fe\uff1b<\/p>\n

\uff08d\uff09 MSNs@RNase A\u7684\u5c3a\u5bf8\uff1b<\/p>\n

\uff08e\uff09 MSNs@RNase A\u7684Zeta\u7535\u4f4d\uff1b<\/p>\n

\uff08f\uff09 MSNs@RNase A@CM\u7684SDS-PAGE\u86cb\u767d\u8d28\u5206\u6790\uff1b<\/p>\n

\uff08g\uff09 HeLa\u7ec6\u80de\u4e2dDiD\u6807\u8bb0\u7684\u764c\u7ec6\u80de\u819c\u4fee\u9970(\u7ea2\u8272)\u548cFITC\u6807\u8bb0\u7684MENs(\u7eff\u8272)\u7684\u7ec6\u80de\u51851 h\u548c6 h\u3002<\/p>\n

\u56fe\u4e94\u3001MSNs@RNase A@CM\u7684\u540c\u6e90\u9776\u5411\u6027\u3001\u514d\u75ab\u9003\u9038\u548c\u6297\u764c\u7279\u6027\u00a0<\/strong><\/p>\n

\"\"<\/strong><\/p>\n

\uff08a\uff09 MSNs@FITC-RNase A@CM\u5b75\u80b26 h\u540e\uff0cHeLa\u7ec6\u80de\u6216RAW264.7\u7ec6\u80de\u7684\u76f8\u5bf9\u8367\u5149\u5f3a\u5ea6\uff1b<\/p>\n

\uff08b\uff09 \u4e0d\u540c\u6d53\u5ea6\u7684MSNs@RNase A\u6216MSNs@RNase A@CM\u5b75\u80b248 h\u5bf9HeLa\u7ec6\u80de\u7684\u7ec6\u80de\u6bd2\u6027\uff1b<\/p>\n

\uff08c\uff09 \u5c0f\u9f20\u4e2dcy5.5\u6807\u8bb0\u7684MSNs@RNase A@CM\u7684\u5faa\u73af\u65f6\u95f4\uff1b<\/p>\n

\uff08d\uff09 \u9759\u8109\u6ce8\u5c04HeLa\u80bf\u7624\u88f8\u9f2024 h\u540e\uff0ccy5.5\u6807\u8bb0\u7684MSNs@RNase A@CM\u7684\u751f\u7269\u5206\u5e03\uff1b<\/p>\n

\uff08e\uff09 MSNs@RNase A@CM\u5904\u7406HeLa\u80bf\u7624\u88f8\u9f2028 d\u540e\u7684\u80bf\u7624\u7167\u7247\uff1b<\/p>\n

\uff08f\uff09 MSNs@RNase A@CM\u5904\u7406HeLa\u80bf\u7624\u88f8\u9f2028 d\u540e\u7684\u80bf\u7624\u4f53\u79ef\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

\u7814\u7a76\u4e86\u5f00\u53d1\u5177\u6709\u5927\u5185\u90e8\u5b54\u5f84\u7684\u4e8c\u7852\u5316\u7269\u6865\u8054MSNs\uff0c\u7528\u4e8e\u57fa\u8d28\u964d\u89e3\u63a7\u91ca\u7684\u86cb\u767d\u8d28\u9012\u9001\u3002\u8d1f\u8f7dRNase A\u7684MSNs\u5177\u6709\u6c27\u5316\/\u6c27\u5316\u8fd8\u539f\u53cc\u54cd\u5e94\u7684\u86cb\u767d\u91ca\u653e\u3002\u7528\u764c\u7ec6\u80de\u819c\u7684\u7247\u6bb5\u8fdb\u884c\u8868\u9762\u4fee\u9970\u540e\u7684MSNs@RNase A@CM\u663e\u793a\u51fa\u540c\u6e90\u9776\u5411\u6027\u548c\u514d\u75ab\u4fb5\u88ad\u6027\u7279\u5f81\uff0c\u5bfc\u81f4\u4f53\u5916\u548c\u4f53\u5185\u6297\u764c\u6548\u679c\u7684\u6539\u5584\u4ee5\u53ca\u8f83\u4f4e\u7684\u5168\u8eab\u6bd2\u6027\u3002\u867d\u7136\u4e8c\u786b\u5316\u7269\u548c\u4e8c\u7852\u5316\u7269\u7684MSNs\u5177\u6709\u76f8\u4f3c\u7684\u6c27\u5316\u8fd8\u539f\u54cd\u5e94\u751f\u7269\u964d\u89e3\u6027\uff0c\u4f46\u662f\u57fa\u4e8e\u4e8c\u7852\u5316\u7269\u7684MSNs\u5bf9\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684ROS\u4e5f\u654f\u611f\uff0c\u589e\u52a0\u4e86\u8be5\u9012\u9001\u7cfb\u7edf\u7684\u591a\u529f\u80fd\u6027\u3002\u63d0\u51fa\u7684\u4e00\u79cd\u591a\u54cd\u5e94\u53ef\u964d\u89e3\u7eb3\u7c73\u8f7d\u4f53\u7528\u4e8e\u63a7\u5236\u9012\u9001\u751f\u7269\u5927\u5206\u5b50\uff08\u86cb\u767d\u8d28\u548c\u6838\u9178\u6cbb\u7597\u5242\uff09\u5177\u6709\u6309\u9700\u91ca\u653e\u548c\u4f4e\u6bd2\u6027\u7684\u53ef\u80fd\u6027\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aBioinspired Diselenide-Bridged Mesoporous Silica Nanoparticles for Dual-Responsive Protein Delivery<\/a><\/strong>\uff08Adv. Mater., 2018<\/strong>, DOI: 10.1002\/adma.201801198\uff09<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u751f\u7269\u6750\u6599\u7ec4\u5c0f\u80d6\u7eb8\u7f16\u8bd1\u3002<\/strong><\/p>\n

\u6750\u6599\u725b\u7f51\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u662f\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c\u70b9\u6211\u52a0\u5165\u6750\u6599\u4eba\u7f16\u8f91\u90e8<\/a><\/strong>\u3002<\/p>\n

\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1tougao@cailiaoren.com.<\/p>\n

\u6295\u7a3f\u4ee5\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1acailiaokefu.<\/p>\n

\u6750\u6599\u6d4b\u8bd5\uff0c\u6570\u636e\u5206\u6790\uff0c\u4e0a\u6d4b\u8bd5\u8c37<\/a><\/strong>\uff01<\/p>\n","protected":false},"excerpt":{"rendered":"

\u3010\u5f15\u8a00\u3011 \u4ecb\u5b54\u4e8c\u6c27\u5316\u7845\u7eb3\u7c73\u9897\u7c92\uff08MSNs\uff09\u7531\u4e8e\u5176\u53ef\u8c03\u8282\u7684\u5b54\u5f84\u3001\u5f62\u6001\u548c\u8868\u9762\u5b98\u80fd\u5316\u800c\u5728\u836f\u7269\u9012\u9001\u4e2d\u53d7\u5230\u76f8\u5f53\u5927\u7684\u5173\u6ce8\uff0c\u4f46\u662f\u7eaf\u65e0\u673a\u9aa8\u67b6\u7684\u7f13\u6162\u751f\u7269\u964d\u89e3\u6027\u9650\u5236\u4e86\u5b83\u4eec\u7684\u5e94\u7528\uff0c\u7279…<\/p>\n","protected":false},"author":7770,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215,2],"tags":[3442],"class_list":["post-147253","post","type-post","status-publish","format-standard","hentry","category-jiedu","category-keji","tag-msnsrnaseacm"],"_links":{"self":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/147253"}],"collection":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/users\/7770"}],"replies":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=147253"}],"version-history":[{"count":4,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/147253\/revisions"}],"predecessor-version":[{"id":147309,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/147253\/revisions\/147309"}],"wp:attachment":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=147253"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=147253"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=147253"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}