{"id":149420,"date":"2018-08-09T06:06:19","date_gmt":"2018-08-08T22:06:19","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=149420"},"modified":"2018-08-08T16:07:24","modified_gmt":"2018-08-08T08:07:24","slug":"%e6%b9%96%e5%8d%97%e5%a4%a7%e5%ad%a6%e8%b0%ad%e8%94%9a%e6%b3%93%e9%99%a2%e5%a3%abj-am-chem-soc-%e4%b8%89%e7%bb%b4%e7%ba%b3%e7%b1%b3%e9%80%bb%e8%be%91%e6%9c%ba%e5%99%a8%e7%94%a8%e4%ba%8e%e7%99%8c","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=149420","title":{"rendered":"\u6e56\u5357\u5927\u5b66\u8c2d\u851a\u6cd3\u9662\u58ebJ. Am. Chem. Soc.: \u4e09\u7ef4\u7eb3\u7c73\u903b\u8f91\u673a\u5668\u7528\u4e8e\u764c\u7ec6\u80de\u8868\u9762\u8fd0\u7b97\u8bc6\u522b"},"content":{"rendered":"

\u3010\u5f15\u8a00<\/b><\/strong>\u3011<\/p>\n

\u7ec6\u80de\u8868\u9762\u5b58\u5728\u6210\u5343\u4e0a\u4e07\u79cd\u53d7\u4f53\uff0c\u4ed6\u4eec\u5728\u7ec6\u80de\u7684\u4ea4\u6d41\u3001\u6210\u957f\u3001\u589e\u503c\u548c\u6b7b\u4ea1\u4e2d\u626e\u6f14\u91cd\u8981\u89d2\u8272\uff0c\u5e76\u4e14\u53ef\u4f5c\u4e3a\u75be\u75c5\u8bca\u65ad\u3001\u6cbb\u7597\u548c\u751f\u7269\u533b\u5b66\u5de5\u7a0b\u7684\u751f\u7269\u6807\u5fd7\u7269\u3002\u8fd1\u5e74\u6765\uff0c\u57fa\u4e8e\u5206\u5b50\u8bc6\u522b\u7684DNA\u5206\u5b50\u673a\u5668\u9886\u57df\u53d6\u5f97\u8fc5\u731b\u53d1\u5c55\uff0c\u4e3a\u764c\u75c7\u7684\u7cbe\u51c6\u8bca\u7597\u63d0\u4f9b\u4e86\u65b0\u7684\u5206\u5b50\u8bbe\u8ba1\u7b56\u7565\u4e0e\u624b\u6bb5\u3002\u901a\u8fc7\u96c6\u6210\u5404\u5206\u5b50\u5143\u5668\u4ef6\u7684\u7eb3\u7c73\u673a\u5668\u6765\u8bc6\u522b\u8fd9\u4e9b\u751f\u7269\u6807\u5fd7\u7269\uff0c\u7136\u540e\u8fd0\u7b97\u4ea7\u751f\u7279\u5f02\u7684\u54cd\u5e94\u4fe1\u53f7\uff0c\u53ef\u5b9e\u73b0\u764c\u7ec6\u80de\u7684\u7cbe\u51c6\u8bc6\u522b\uff0c\u5728\u4eba\u5de5\u5206\u5b50\u5668\u4ef6\u548c\u751f\u7269\u533b\u836f\u9886\u57df\u5177\u6709\u5de8\u5927\u6f5c\u529b\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb<\/b><\/strong>\u3011<\/p>\n

\u8fd1\u65e5\uff0c\u6e56\u5357\u5927\u5b66<\/b><\/strong>\u7684\u8c2d\u851a\u6cd3\u9662\u58eb\u548c\u5ba6\u53cc\u71d5\u6559\u6388\uff08\u5171\u540c\u901a\u8baf\uff09<\/b><\/strong>\u56e2\u961f\u8bbe\u8ba1\u5e76\u6784\u5efa\u4e86\u4e00\u79cd\u57fa\u4e8e\u6838\u9178\u9002\u4f53\u548cDNA\u4e09\u68f1\u67f1(TP)\u7684\u4e09\u7ef4\u7eb3\u7c73\u903b\u8f91\u673a\u5668\u3002\u8fd9\u79cd\u7eb3\u7c73\u7ea7\u673a\u5668\u53ef\u5728\u764c\u7ec6\u80de\u819c\u8868\u9762\u5b9e\u73b0\u5e03\u5c14\u903b\u8f91\u8fd0\u7b97\uff0c\u5c55\u73b0\u51fa\u7cbe\u51c6\u8bca\u7597\u7684\u6f5c\u529b\u3002\u76f8\u6bd4\u4e8e\u4f20\u7edf\u7684\u6e38\u79bb\u4e8e\u6eb6\u6db2\u4e2d\u7684\u7ebf\u6027\u53cc\u94feDNA\u8ba1\u7b97\u7cfb\u7edf\uff0c\u8fd9\u79cd\u4e09\u7ef4DNA\u7eb3\u7c73\u673a\u5668\u96c6\u6210\u4e86\u6240\u6709\u7684\u903b\u8f91\u8fd0\u7b97\u5355\u5143\uff0c\u5f53\u7279\u5b9a\u7ec6\u80de\u7c7b\u578b\u51fa\u73b0\u65f6\uff0c\u8fd0\u7b97\u4ea7\u751f\u7279\u5f02\u7684\u54cd\u5e94\u4fe1\u53f7\uff0c\u5927\u5927\u63d0\u5347\u4e86\u7ec6\u80de\u8bc6\u522b\u7684\u51c6\u786e\u6027\u3002\u8fd9\u79cd\u5206\u5b50\u96c6\u6210\u8bbe\u8ba1\u7b56\u7565\u5177\u6709\u5e7f\u9614\u7684\u6f5c\u529b\u3002\u8be5\u6210\u679c\u4ee5\u9898\u4e3a”Engineering a 3D DNA-Logic Gate Nanomachine for Bispecific Recognition and Computing on Target Cell Surfaces<\/b><\/strong>“\u53d1\u8868\u5728J. Am. Chem. Soc.<\/b><\/strong>\u4e0a\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/b><\/strong><\/p>\n

\u56fe<\/b><\/strong>1<\/b><\/strong>.DNA\u7eb3\u7c73\u673a\u5668\u7684\u5de5\u4f5c\u539f\u7406<\/b><\/strong><\/p>\n

\"\"<\/p>\n

\u56fe<\/b><\/strong>2<\/b><\/strong>.<\/b><\/strong>\u4e09\u7ef4DNA\u903b\u8f91\u7eb3\u7c73\u673a\u5668\u5728\u6eb6\u6db2\u4e2d\u7684\u81ea\u7ec4\u88c5\u548c\u52a8\u6001\u903b\u8f91\u8fd0\u7b97<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a).\u57fa\u4e8eDNA\u4e09\u68f1\u67f1\uff08TP\uff09\u7684\u7eb3\u7c73\u903b\u8f91\u673a\u5668\u94fe\u7f6e\u6362\u793a\u610f\u56fe\uff1b<\/p>\n

(b).DNA\u903b\u8f91TP\u5206\u6b65\u81ea\u7ec4\u88c5\u7684\u7535\u6cf3\u7ed3\u679c\uff1b<\/p>\n

(c).DLS\u7ed3\u679c\uff1b<\/p>\n

(e).DNA\u903b\u8f91TP\u52a8\u6001\u884c\u4e3a\u7684\u6d3b\u6027\u7535\u6cf3\u7ed3\u679c<\/p>\n

(f).cS\u6216cF\u7684\u6bd4\u4f8b\u4f18\u5316<\/p>\n

(g). DNA\u903b\u8f91TP\u5bf9DNA\u94fe\u7f6e\u6362\u7684\u8367\u5149\u53d8\u5316<\/p>\n

\u56fe<\/b><\/strong>3<\/b><\/strong>.<\/b><\/strong>\u7ebf\u6027\u53cc\u94feDNA\u548c\u4e09\u7ef4DNA\u903b\u8f91TP\u5728\u7ec6\u80de\u8868\u9762\u9776\u5411\u4e2d\u7684\u533a\u522b<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a).\u7ebf\u6027\u53cc\u94feDNA\u548c\u4e09\u7ef4DNA\u903b\u8f91TP\u572810%FBS\u4e2d\u7684\u7a33\u5b9a\u6027\u8003\u5bdf\uff1b<\/p>\n

(b).\u7ebf\u6027\u53cc\u94feDNA\u548c\u4e09\u7ef4DNA\u903b\u8f91TP\u5728\u9776\u7ec6\u80de\u8868\u9762\u5206\u5b50\u8fd0\u7b97\u7684\u56fe\u793a\uff1b<\/p>\n

(c).\u00a0\u6d41\u5f0f\u7ec6\u80de\u672f\u5bf9\u5404\u7ec4\u7684\u8367\u5149\u5f3a\u5ea6\u5206\u6790\uff1b<\/p>\n

\u56fe<\/b><\/strong>4<\/b><\/strong>.<\/b><\/strong>\u4e09\u7ef4DNA\u903b\u8f91\u7eb3\u7c73\u673a\u5668\u7528\u4e8e\u8bc6\u522b\u7ec6\u80de\u8868\u9762<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a).\u6d41\u5f0f\u7ec6\u80de\u672f\u5206\u6790\uff1b<\/p>\n

(b).\u6fc0\u5149\u5171\u805a\u7126\u6210\u50cf\uff1b<\/p>\n

(c).DNA\u903b\u8f91\u95e8\u8fd0\u7b97\u771f\u503c\u8868\uff1b<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/b><\/strong><\/p>\n

\u5728\u8fd9\u4e2a\u5de5\u4f5c\u4e2d\uff0c\u5f6d\u745e\u8d44<\/b><\/strong>\u548c\u90d1\u5c0f\u82b3<\/b><\/strong>\u662f\u672c\u6587\u7684\u5e76\u5217\u7b2c\u4e00\u4f5c\u8005<\/b><\/strong>\uff0c\u4ed6\u4eec\u5171\u540c\u8bbe\u8ba1\u548c\u6784\u5efa\u4e86\u4e00\u79cd\u57fa\u4e8e\u9002\u914d\u4f53\u7684\u4e09\u7ef4DNA\u903b\u8f91\u95e8TP\u7eb3\u7c73\u673a\u5668\u3002\u8fd9\u79cd\u7eb3\u7c73\u673a\u5668\u9664\u4e86\u5728\u764c\u75c7\u7ec6\u80de\u819c\u8868\u9762\u5b9e\u73b0\u5e03\u6797\u903b\u8f91\u8fd0\u7b97\uff0c\u8fd8\u53ef\u4ee5\u8f7b\u6613\u8fdb\u5165\u7ec6\u80de\u5185\uff0c\u5c55\u73b0\u51fa\u8bca\u7597\u7684\u6f5c\u529b\u3002\u4e0e\u57fa\u4e8e\u7ebf\u6027\u53cc\u94feDNA\u76f8\u6bd4\uff0c\u8fd9\u79cd\u4e09\u7ef4DNA\u7eb3\u7c73\u673a\u5668\u96c6\u6210\u4e86\u6240\u6709\u7684\u903b\u8f91\u8fd0\u7b97\u5355\u5143\uff0c\u5f53\u7279\u5b9a\u7ec6\u80de\u7c7b\u578b\u51fa\u73b0\u65f6\uff0c\u8fd0\u7b97\u4ea7\u751f\u7279\u5f02\u7684\u54cd\u5e94\u4fe1\u53f7\uff0c\u5927\u5927\u63d0\u5347\u4e86\u7ec6\u80de\u8bc6\u522b\u7684\u51c6\u786e\u6027\u3002\u8be5\u7814\u7a76\u5f97\u5230\u4e86\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u59d4\u3001\u79d1\u6280\u90e8\u3001\u6559\u80b2\u90e8\u7b49\u90e8\u95e8\u7684\u79d1\u7814\u8d44\u52a9\u3002<\/p>\n

Engineering a 3D DNA-Logic Gate Nanomachine for Bispecific Recognition and Computing on Target Cell Surfaces<\/a><\/p>\n

\u00a0(J. Am. Chem. Soc., 2018, DOI: 10. 1021\/jacs.8b04319)<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u5b66\u672f\u7ec4gaxy\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u6574\u7406\u7f16\u8f91\u3002 \u00a0<\/p>\n

\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1tougao@cailiaoren.com\u3002<\/p>\n

\u6295\u7a3f\u4ee5\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1acailiaokefu\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u3010\u5f15\u8a00\u3011 \u7ec6\u80de\u8868\u9762\u5b58\u5728\u6210\u5343\u4e0a\u4e07\u79cd\u53d7\u4f53\uff0c\u4ed6\u4eec\u5728\u7ec6\u80de\u7684\u4ea4\u6d41\u3001\u6210\u957f\u3001\u589e\u503c\u548c\u6b7b\u4ea1\u4e2d\u626e\u6f14\u91cd\u8981\u89d2\u8272\uff0c\u5e76\u4e14\u53ef\u4f5c\u4e3a\u75be\u75c5\u8bca\u65ad\u3001\u6cbb\u7597\u548c\u751f\u7269\u533b\u5b66\u5de5\u7a0b\u7684\u751f\u7269\u6807\u5fd7\u7269\u3002\u8fd1\u5e74\u6765\uff0c\u57fa\u4e8e\u5206\u5b50\u8bc6\u522b…<\/p>\n","protected":false},"author":7336,"featured_media":149427,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215],"tags":[75],"class_list":["post-149420","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-jiedu","tag-biomaterial"],"_links":{"self":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/149420"}],"collection":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/users\/7336"}],"replies":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=149420"}],"version-history":[{"count":5,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/149420\/revisions"}],"predecessor-version":[{"id":149835,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/149420\/revisions\/149835"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/media\/149427"}],"wp:attachment":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=149420"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=149420"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=149420"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}