{"id":151630,"date":"2018-08-22T06:30:18","date_gmt":"2018-08-21T22:30:18","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=151630"},"modified":"2018-08-22T10:26:56","modified_gmt":"2018-08-22T02:26:56","slug":"%e5%be%b7%e5%9b%bd%e5%9f%83%e5%b0%94%e6%9c%97%e6%a0%b9-%e7%ba%bd%e4%bc%a6%e5%a0%a1%e5%a4%a7%e5%ad%a6%e7%9a%84andriy-mokhir-%e6%95%99%e6%8e%88%e8%af%be%e9%a2%98%e7%bb%84-angew%e9%ab%98%e6%95%88","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=151630","title":{"rendered":"\u5fb7\u56fd\u57c3\u5c14\u6717\u6839-\u7ebd\u4f26\u5821\u5927\u5b66\u7684Andriy Mokhir\u00a0\u6559\u6388\u8bfe\u9898\u7ec4 Angew:\u9ad8\u6548\u7387\u3001\u9ad8\u7279\u5f02\u6027\u80bf\u7624\u7ebf\u7c92\u4f53\u819c\u9776\u5411\u7684\u5316\u5408\u57fa\u56e2"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-151631 aligncenter\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/08\/1-38.png\" alt=\"\" width=\"600\" height=\"549\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/08\/1-38.png 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/08\/1-38-300x275.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\u5728\u8fc7\u53bb\u7684\u5341\u5e74\u91cc\uff0c\u764c\u75c7\u7684\u6cbb\u7597\u53d6\u5f97\u8f83\u5927\u7684\u8fdb\u5c55\uff0c\u5c24\u5176\u662f\u4e00\u4e9b\u8f83\u597d\u7684\u9776\u5411\u836f\u7684\u51fa\u73b0\uff0c\u4f7f\u764c\u75c7\u7684\u81f4\u6b7b\u7387\u8fde\u7eed\u964d\u4f4e\u3002\u76ee\u524d\uff0c\u589e\u52a0\u836f\u7269\u9776\u5411\u6027\u7684\u65b9\u6cd5\u5305\u62ec\uff1a\u8bbe\u8ba1\u80fd\u9776\u5411\u80bf\u7624\u7ec6\u80de\u4e2d\u8fc7\u8868\u8fbe\u7684\u751f\u7269\u5927\u5206\u5b50\uff08\u86cb\u767d\u6fc0\u9176\u3001\u7279\u5f02\u6027\u53d7\u4f53\uff09\u6216\u8005\u662f\u80fd\u5bf9\u80bf\u7624\u73af\u5883\u54cd\u5e94\uff08\u8f83\u9ad8\u6c34\u5e73\u7684\u6d3b\u6027\u6c27\uff09\u7684\u57fa\u56e2\u3002\u7ebf\u7c92\u4f53\u56e0\u5176\u5728\u7ec6\u80de\u4e2d\u7684\u91cd\u8981\u4f5c\u7528\uff0c\u6210\u4e3a\u6297\u764c\u836f\u7269\u9776\u5411\u7684\u8f83\u597d\u9009\u62e9\u3002\u7ebf\u7c92\u4f53\u7684\u819c\u7535\u4f4d\u5728\u80bf\u7624\u7ec6\u80de\u4e2d\u6bd4\u5728\u6b63\u5e38\u7ec6\u80de\u4e2d\u4f4e\uff0c\u6240\u4ee5\u79bb\u57df\u4eb2\u8102\u9633\u79bb\u5b50\uff08DLC\uff09\u53ef\u4ee5\u7528\u4f5c\u80bf\u7624\u7684\u9776\u5411\u57fa\u56e2\u3002\u4f46\u662f\u80bf\u7624\u7ec6\u80de\u548c\u6b63\u5e38\u7ec6\u80de\u4e2d\u7684\u7535\u52bf\u76f8\u5dee\u4e0d\u5927\uff0c\u6240\u4ee5\u8fd9\u7c7b\u9776\u5411\u836f\u4e5f\u53ef\u80fd\u4f1a\u4f5c\u7528\u4e8e\u6b63\u5e38\u7ec6\u80de\u3002<\/p>\n<p>\u8fd1\u65e5\uff0c\u5fb7\u56fd\u57c3\u5c14\u6717\u6839-\u7ebd\u4f26\u5821\u5927\u5b66\u7684Andriy Mokhir\u00a0\u6559\u6388\u8bfe\u9898\u7ec4\u63d0\u51fa\u4e86\u201c<strong><b>\u6d3b\u6027\u6c27\u54cd\u5e94\u57fa\u56e2\u4fdd\u62a4\u7ebf\u7c92\u4f53\u9776\u5411\u57fa\u56e2<\/b><\/strong><strong><b>\u201d<\/b><\/strong><strong><b>\u7684<\/b><\/strong>\u6982\u5ff5\uff08<strong><b>pro-DLCs<\/b><\/strong>\uff09\uff08\u56fe1A\uff09\u3002\u4f5c\u8005\u7528\u6d3b\u6027\u6c27\u54cd\u5e94\u7684\u5316\u5b66\u7ed3\u6784\u8fde\u63a5\u79bb\u57df\u4eb2\u8102\u9633\u79bb\u5b50N-\u70f7\u57fa\u6c28\u57fa\u4e8c\u8302\u94c1\uff08\u56fe1B\uff09\uff0c\u8fd9\u6837\u7684\u8bc6\u522b\u57fa\u56e2\u5bf9\u80bf\u7624\u7ec6\u80de\u5185\u7ebf\u7c92\u4f53\u5177\u6709\u66f4\u5f3a\u7684\u9776\u5411\u6027\u3002\u76f8\u5173\u6210\u679c\u4ee5\u201cROS-responsive N-alkylaminoferrocenes for cancer cell specific<\/p>\n<p>targeting of mitochondria\u201d\u53d1\u8868\u5728Angew. Chem.\uff08DOI\uff1a10.1002\/anie.201805955\uff09<\/p>\n<p>\u56fe1.\u00a0<strong><b>pro-DLCs<\/b><\/strong>\u54cd\u5e94\u539f\u7406\u53ca\u76f8\u5173\u5316\u5b66\u7ed3\u6784\u5f0f<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-151632 aligncenter\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/08\/2-36.png\" alt=\"\" width=\"600\" height=\"550\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/08\/2-36.png 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/08\/2-36-300x275.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\uff08\u6765\u6e90\uff1a<em><i>A<\/i><\/em><em><i>ngew. Chem. Int. Ed.<\/i><\/em><em><i>\uff09<\/i><\/em><\/p>\n<p>\u4f5c\u8005\u5408\u6210\u4e86\u4e00\u4e9b\u5316\u5408\u7269\u4fa7\u9762\u8bc1\u660e\u8bc6\u522b\u57fa\u56e2\u8d85\u5f3a\u7684\u9009\u62e9\u6027\u3002\u9996\u5148\uff0c\u4f5c\u8005\u8fde\u63a5\u4e24\u79cd\u8367\u5149\u57fa\u56e2\u5408\u6210<strong><b>pro-DLCs<\/b><\/strong>\u00a0<strong><b>1<\/b><\/strong>\u548c <strong><b>pro-DLCs2<\/b><\/strong>\uff08\u56fe1B)\uff0c\u901a\u8fc7\u7528<strong><b>pro-DLCs<\/b><\/strong>\u00a0<strong><b>1<\/b><\/strong>\u4e0e\u5e02\u9762\u4e0a\u7684\u7ebf\u7c92\u4f53\u793a\u8e2a\u67d3\u6599R123\u5171\u540c\u5b75\u80b2\u80bf\u7624\u7ec6\u80de\uff08A2780 cells\uff09\u548c\u4eba\u4f53\u6b63\u5e38\u7ec6\u80de\uff08NHDF cells\uff09\uff0c\u53ef\u4ee5\u53d1\u73b0R123\u548c<strong><b>pro-DLCs<\/b><\/strong>\u00a0<strong><b>1<\/b><\/strong>\u80fd\u5728\u80bf\u7624\u7ec6\u80de\u8fdb\u884c\u5171\u5b9a\u4f4d\u8367\u5149\u6210\u50cf\uff0c\u800c\u5728\u6b63\u5e38\u7ec6\u80de\u4e2d\u53ea\u80fd\u68c0\u6d4b\u5230R123\u7684\u8367\u5149\uff08\u56fe2a\uff0cc\uff09\u3002\u7136\u540e\uff0c\u4f5c\u8005\u5728\u6b63\u5e38\u7ec6\u80de\u4e2d\u52a0\u5165H<sub>2<\/sub>O<sub>2<\/sub>\u6a21\u62df\u80bf\u7624\u7279\u5f02\u6027\u73af\u5883\uff0c\u53d1\u73b0\u6b63\u5e38\u7ec6\u80de\u4e2d\u4e5f\u80fd\u68c0\u6d4b\u5230R123\u548c<strong><b>pro-DLCs<\/b><\/strong>\u00a0<strong><b>1<\/b><\/strong><strong><b>\u7684<\/b><\/strong><strong><b>\u5171\u5b9a\u4f4d<\/b><\/strong><strong><b>\u8367\u5149<\/b><\/strong>\uff08\u56fe2d\uff09\u3002\u6700\u540e\uff0c\u4f5c\u8005\u5206\u522b\u7528<strong><b>pro-DLCs<\/b><\/strong>\u00a0<strong><b>2<\/b><\/strong>\u548c\u672a\u7ecf\u4fee\u9970\u7684<strong><b>8<\/b><\/strong>\uff08\u56fe1C)\u4e0e\u5e02\u552e\u7ebf\u7c92\u4f53\u5171\u5b9a\u4f4d\u67d3\u6599TMR\u5171\u5b75\u80b2\u80bf\u7624\u7ec6\u80de\uff0c\u53d1\u73b0\u53ea\u6709<strong><b>pro-DLCs<\/b><\/strong>\u00a0<strong><b>2<\/b><\/strong>\u80fd\u4e0eTMR\u5171\u5b9a\u4f4d\u3002<\/p>\n<p>\u56fe2.\u5e02\u552e\u67d3\u6599\u4e0e\u5404\u7c7bpro-DLC\u5316\u5408\u7269\u5171\u805a\u7126\u5bf9\u6bd4\u56fe<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-151633 aligncenter\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/08\/3-37.png\" alt=\"\" width=\"600\" height=\"779\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/08\/3-37.png 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/08\/3-37-231x300.png 231w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\uff08\u6765\u6e90\uff1a<em><i>A<\/i><\/em><em><i>ngew. Chem. Int. Ed.<\/i><\/em><em><i>\uff09<\/i><\/em><\/p>\n<p>\u5728\u80bf\u7624\u6cbb\u7597\u7684\u8fd0\u7528\u4e2d\uff0c\u4f5c\u8005\u5171\u4ef7\u8fde\u63a5\u4e34\u5e8a\u7528\u6297\u764c\u836f\u5361\u6ce2\u94c2carboplatin\u5408\u6210<strong><b>pro-DLCs3<\/b><\/strong>\u3002IC<sub>50<\/sub>\u5b9e\u9a8c\u7684\u7ed3\u679c\u663e\u793a<strong><b>pro-DLCs3<\/b><\/strong>\u4e0e\u5316\u5408\u7269<strong><b>9<\/b><\/strong>\u6709\u63a5\u8fd1\u7684\u836f\u7269\u6d3b\u6027\uff0c\u4e14\u5747\u8fdc\u9ad8\u4e8e\u5316\u5408\u7269<strong><b>pro-DLCs6 <\/b><\/strong>\u548c<strong><b>11<\/b><\/strong>\uff08\u56fe3A\uff09\u3002\u56e0\u4e3a<strong><b>pro-DLCs3<\/b><\/strong>\u5728\u7ec6\u80de\u4e2d\u7684\u79ef\u7d2f\u6548\u7387\u4e0elogP\u503c\u5177\u6709\u76f8\u5173\u6027\uff0c<strong><b>pro-DLCs3<\/b><\/strong>\u53ea\u80fd\u662f\u901a\u8fc7\u88ab\u52a8\u8fd0\u8f93\u79ef\u7d2f\u5230\u7ec6\u80de\u5185\uff08\u56fe3B\uff09\u3002\u968f\u540e\uff0c\u4f5c\u8005\u53d1\u73b0<strong><b>pro-DLCs3<\/b><\/strong>\u8fd0\u8f7dPt\u7684\u6548\u7387\u9ad8\u4e8e\u5316\u5408\u7269<strong><b>11<\/b><\/strong>\uff08\u56fe3C\uff09\uff0c\u4fa7\u9762\u8bc1\u660e\u54cd\u5e94\u7ed3\u6784\u5728\u9776\u5411\u4e0a\u7684\u4f18\u8d8a\u6027\u3002\u6700\u540e\uff0c\u4f5c\u8005\u901a\u8fc7\u4e00\u7cfb\u5217\u673a\u5236\u63a2\u7d22\u5b9e\u9a8c\uff0c\u77e5\u9053<strong><b>pro-DLCs3\u80fd\u8f83\u5927\u7a0b\u5ea6\u7684\u589e\u52a0\u80bf\u7624\u7ec6\u80de\u7ebf\u7c92\u4f53\u819c\u7684\u7535\u52bf<\/b><\/strong>\uff08\u56fe3D\uff09<strong><b>\uff0c\u51cf\u5c11\u7ec6\u80de\u5185GSH\u6d53\u5ea6<\/b><\/strong>\uff08\u56fe3E\uff09<strong><b>\uff0c\u589e\u52a0\u7ec6\u80de\u5185\u7684\u6d3b\u6027\u6c27\u6d53\u5ea6<\/b><\/strong>\uff08\u56fe3F\uff09<strong><b>\uff0c\u5e76\u4e14\u5bf9\u764c\u7ec6\u80de\u5468\u671f\u7684\u5f71\u54cd\u8f83\u5c0f<\/b><\/strong>\uff08\u56fe3G\uff09<strong><b>\u3002<\/b><\/strong><\/p>\n<p>\u56fe3.pro-DLCs3\u7684\u6297\u764c\u673a\u5236\u63a2\u7d22<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-151634 aligncenter\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/08\/4-30.png\" alt=\"\" width=\"600\" height=\"393\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/08\/4-30.png 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/08\/4-30-300x197.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\uff08\u6765\u6e90\uff1a<em><i>A<\/i><\/em><em><i>ngew. Chem. Int. Ed.<\/i><\/em><em><i>\uff09<\/i><\/em><\/p>\n<p>\u4f5c\u8005\u5728\u672c\u6587\u4e2d\u8bc1\u660e\u4e86\u5176\u5408\u6210\u7684\u8bc6\u522b\u57fa\u56e2\u80fd\u7279\u5f02\u6027\u9776\u5411\u80bf\u7624\u7ec6\u80de\u7684\u7ebf\u7c92\u4f53\u819c\u7ed3\u6784\uff0c\u6240\u5408\u6210\u7684<strong><b>pro-DLCs<\/b><\/strong>\u00a0<strong><b>1\u3001pro-DLCs<\/b><\/strong>\u00a0<strong><b>2<\/b><\/strong>\u80fd\u548c\u5e02\u552e\u67d3\u6599\u4e00\u6837\u8fdb\u884c\u7ebf\u7c92\u4f53\u819c\u7ed3\u6784\u8367\u5149\u6210\u50cf\uff0c\u4e14\u53ea\u5728\u80bf\u7624\u73af\u5883\u4e2d\u54cd\u5e94\u3002\u968f\u540e\uff0c\u4e00\u7cfb\u5217\u5b9e\u9a8c\u7684\u5b9e\u9a8c\u7ed3\u679c\u663e\u793a\u51fa<strong><b>pro-DLCs3<\/b><\/strong>\u7684\u4e34\u5e8a\u4f7f\u7528\u7684\u4f18\u8d8a\u6027\uff1a\u8f83\u5f3a\u7684\u836f\u7269\u6d3b\u6027\uff0c\u8f83\u9ad8\u7684\u836f\u7269\u8fd0\u8f7d\u6548\u7387\u3002\u5e76\u4e14\uff0c<strong><b>pro-DLCs3\u8f83\u9ad8\u7684\u836f\u7269\u6d3b\u6027\u53d6\u51b3\u4e8e\u5176\u5bf9\u80bf\u7624\u7ec6\u80de\u7ebf\u7c92\u4f53\u7535\u52bf\u3001\u8c37\u80f1\u7518\u80bd\uff08GSH\uff09\u4ee5\u53ca\u6d3b\u6027\u6c27\uff08ROS\uff09\u7684\u5f71\u54cd\u3002<\/b><\/strong>\u8fd9\u6837\u7684\u7ed3\u6784\u5177\u6709\u7b80\u5355\u7684\u54cd\u5e94\u5f62\u5f0f\u4e14\u9ad8\u6548\u7684\u54cd\u5e94\u6548\u7387\uff0c\u5bf9\u4e34\u5e8a\u4e0a\u80bf\u7624\u7684\u8bca\u65ad\u53ca\u6cbb\u7597\u5177\u6709\u91cd\u5927\u610f\u4e49\u3002<\/p>\n<p>\u672c\u6587\u7531\u7f51\u7edc\u4f5c\u8005\u96e8\u56de<span style=\"font-family: \u5fae\u8f6f\u96c5\u9ed1;\">\u4f9b\u7a3f<\/span>\uff0c\u6750\u6599\u725b\u6574\u7406\u7f16\u8f91\u3002<\/p>\n<p>\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1tougao@cailiaoren.com\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5728\u8fc7\u53bb\u7684\u5341\u5e74\u91cc\uff0c\u764c\u75c7\u7684\u6cbb\u7597\u53d6\u5f97\u8f83\u5927\u7684\u8fdb\u5c55\uff0c\u5c24\u5176\u662f\u4e00\u4e9b\u8f83\u597d\u7684\u9776\u5411\u836f\u7684\u51fa\u73b0\uff0c\u4f7f\u764c\u75c7\u7684\u81f4\u6b7b\u7387\u8fde\u7eed\u964d\u4f4e\u3002\u76ee\u524d\uff0c\u589e\u52a0\u836f\u7269\u9776\u5411\u6027\u7684\u65b9\u6cd5\u5305\u62ec\uff1a\u8bbe\u8ba1\u80fd\u9776\u5411\u80bf\u7624\u7ec6\u80de\u4e2d\u8fc7\u8868\u8fbe\u7684\u751f\u7269&#8230;<\/p>\n","protected":false},"author":9133,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215],"tags":[],"class_list":["post-151630","post","type-post","status-publish","format-standard","hentry","category-jiedu"],"_links":{"self":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/151630"}],"collection":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/users\/9133"}],"replies":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=151630"}],"version-history":[{"count":6,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/151630\/revisions"}],"predecessor-version":[{"id":151672,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/151630\/revisions\/151672"}],"wp:attachment":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=151630"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=151630"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=151630"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}