{"id":153707,"date":"2018-09-18T06:57:11","date_gmt":"2018-09-17T22:57:11","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=153707"},"modified":"2018-09-17T22:57:55","modified_gmt":"2018-09-17T14:57:55","slug":"%e8%8d%a7%e5%85%89%e6%8e%a2%e9%92%88%e7%82%b9%e4%ba%ae%e7%9a%84%e7%94%9f%e5%91%bd%e7%a7%91%e5%ad%a6%e4%b8%96%e7%95%8c-%e6%b9%96%e5%8d%97%e5%a4%a7%e5%ad%a6%e5%bc%a0%e6%99%93%e5%85%b5%e6%95%99%e6%8e%88","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=153707","title":{"rendered":"\u8367\u5149\u63a2\u9488\u70b9\u4eae\u7684\u751f\u547d\u79d1\u5b66\u4e16\u754c \u6e56\u5357\u5927\u5b66\u5f20\u6653\u5175\u6559\u6388\u548c\u8c2d\u851a\u6cd3\u9662\u58eb\u8bfe\u9898\u7ec4Chem. Soc. Rev.: \u5c0f\u5206\u5b50\u8367\u5149\u63a2\u9488\u5728\u764c\u75c7\u6210\u50cf\u4e2d\u7684\u5e94\u7528"},"content":{"rendered":"

\u3010\u5f15\u8a00<\/b><\/strong>\u3011<\/p>\n

\u6839\u636eWHO\u516c\u5e03\u7684\u6570\u636e\uff0c\u52302035\u5e74\uff0c\u5168\u7403\u5c06\u4f1a\u4ea7\u751f2400\u4e07\u4e2a\u764c\u75c7\u65b0\u75c5\u4f8b\u4ee5\u53ca1450\u4e07\u4e2a\u764c\u75c7\u76f8\u5173\u6b7b\u4ea1\u3002\u5728\u8fd9\u4e9b\u764c\u75c7\u76f8\u5173\u7684\u6b7b\u4ea1\u4e2d\uff0c\u6709\u5927\u7ea630%\u7684\u60a3\u8005\u662f\u53ef\u4ee5\u901a\u8fc7\u65e9\u671f\u8bca\u65ad\u633d\u6551\u7684\uff0c\u56e0\u6b64\u4e5f\u8bf4\u660e\u4e86\u764c\u75c7\u65e9\u671f\u8bca\u65ad\u548c\u9776\u5411\u6cbb\u7597\u5728\u63d0\u9ad8\u60a3\u8005\u5b58\u6d3b\u7387\u4e2d\u7684\u91cd\u8981\u6027\u3002<\/p>\n

\u764c\u75c7\u76f8\u5173\u751f\u7269\u6807\u8bb0\u7269\u7684\u68c0\u6d4b\u5728\u4e34\u5e8a\u8bca\u65ad\u4e0a\u6709\u5e7f\u6cdb\u7684\u5e94\u7528\u3002\u5728\u8fd9\u4e9b\u764c\u75c7\u76f8\u5173\u7684\u751f\u7269\u6807\u8bb0\u7269\u4e2d\uff0c\u9176\u56e0\u4e3a\u5728\u8bb8\u591a\u751f\u7406\u3001\u75c5\u7406\u548c\u836f\u7406\u8fc7\u7a0b\u4e2d\u7684\u91cd\u8981\u4f5c\u7528\u800c\u53d7\u5230\u4e86\u5e7f\u6cdb\u7684\u5173\u6ce8\u3002\u524d\u671f\u7684\u7814\u7a76\u4e5f\u5df2\u7ecf\u8bc1\u660e\u9176\u6d3b\u6027\u7684\u5f02\u5e38\u4e0e\u591a\u79cd\u764c\u75c7\u606f\u606f\u76f8\u5173\uff1a\u8c37\u6c28\u9170\u8f6c\u80bd\u9176\u5728\u809d\u764c\u7b49\u591a\u79cd\u764c\u75c7\u4e2d\u6709\u5f88\u9ad8\u8868\u8fbe\uff1b\u78b1\u6027\u78f7\u9178\u9176\u5728\u9aa8\u764c\u4e2d\u6d3b\u6027\u663e\u8457\u589e\u52a0\u3002\u56e0\u6b64\uff0c\u8fd9\u4e9b\u9176\u5728\u80bf\u7624\u7ec6\u80de\u4e2d\u7684\u5b9a\u4f4d\u4ee5\u53ca\u8868\u8fbe\u6c34\u5e73\u5bf9\u764c\u75c7\u7684\u65e9\u671f\u8bca\u65ad\u548c\u6cbb\u7597\u7597\u6548\u6709\u5f88\u5927\u7684\u5f71\u54cd\u3002\u5f88\u591a\u6210\u50cf\u6280\u672f\u5df2\u7ecf\u88ab\u5f00\u53d1\u4e14\u88ab\u5e94\u7528\u5230\u8fd9\u7c7b\u9176\u7684\u68c0\u6d4b\u548c\u6210\u50cf\u4e2d\uff0c\u6bd4\u5982\u78c1\u5171\u632f\u6210\u50cf(MRI)\u3001\u6838\u6210\u50cf\u3001\u6b63\u7535\u5b50\u53d1\u5c04\u65ad\u5c42\u6210\u50cf(PET)\u548c\u8367\u5149\u6210\u50cf\u3002\u6bcf\u4e00\u79cd\u6210\u50cf\u6280\u672f\u90fd\u4e0d\u53ef\u66ff\u4ee3\uff0c\u5e76\u5728\u7075\u654f\u5ea6\u3001\u6210\u50cf\u6df1\u5ea6\u548c\u5206\u8fa8\u7387\u4e0a\u90fd\u6709\u81ea\u5df1\u7684\u7279\u70b9\u3002MRI\u5728\u6d3b\u7ec6\u80de\u4e2d\u5bf9\u4f4e\u542b\u91cf\u7684\u9176\u7f3a\u4e4f\u8db3\u591f\u7684\u7279\u5f02\u6027\u548c\u7075\u654f\u5ea6\uff1bSPECT\u548cPET\u5177\u6709\u8f83\u9ad8\u7684\u7075\u654f\u5ea6\uff0c\u4f46\u5206\u8fa8\u7387\u5374\u4e0d\u5c3d\u5982\u4eba\u610f\u3002<\/p>\n

\u57fa\u4e8e\u5c0f\u5206\u5b50\u8367\u5149\u63a2\u9488\u7684\u8367\u5149\u6210\u50cf\u6280\u672f\u5df2\u88ab\u5e7f\u6cdb\u7528\u4e8e\u6d3b\u7ec6\u80de\u591a\u4e2a\u52a8\u6001\u8fc7\u7a0b\u7684\u53ef\u89c6\u5316\u548c\u91cf\u5316\u4e2d\uff0c\u53ef\u5b9e\u73b0\u9ad8\u7075\u654f\u5ea6\u548c\u5feb\u901f\u65e0\u635f\u7684\u5b9e\u65f6\u68c0\u6d4b\u3002\u5c0f\u5206\u5b50\u8367\u5149\u63a2\u9488\u56e0\u4e3a\u7ed3\u6784\u7684\u53ef\u4fee\u9970\u6027\uff0c\u56e0\u6b64\u53ef\u4ee5\u8ba2\u5236\u5404\u79cd\u5404\u6837\u7684\u63a2\u9488\u6765\u5b9e\u73b0\u7ec6\u80de\u548c\u6d3b\u4f53\u5185\u539f\u751f\u73af\u5883\u4e2d\u9176\u7684\u5b9e\u65f6\u68c0\u6d4b\u548c\u6210\u50cf\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb<\/b><\/strong>\u3011<\/p>\n

\u8fd1\u65e5\uff0c\u6e56\u5357\u5927\u5b66<\/b><\/strong>\u5f20\u6653\u5175\u6559\u6388\uff08\u901a\u8baf\u4f5c\u8005\uff09\u548c\u8c2d\u851a\u6cd3\u9662\u58eb\u8bfe\u9898\u7ec4<\/b><\/strong>\u5728Chem. Soc. Rev.<\/b><\/strong>\u4e0a\uff0c\u53d1\u8868\u4e86\u9898\u4e3a”Recent Progress in Small-Molecule Enzymatic Fluorescent Probes for Cancer Imaging<\/b><\/strong>“\u7684\u7efc\u8ff0\u3002<\/p>\n

\u5728\u8fd9\u7bc7\u7efc\u8ff0\u4e2d\uff0c\u4f5c\u8005\u603b\u7ed3\u4e86\u9488\u5bf9\u9176\u7684\u5c0f\u5206\u5b50\u8367\u5149\u63a2\u9488\u5728\u764c\u75c7\u6210\u50cf\u4e2d\u7684\u53d1\u5c55\u3002\u6587\u7ae0\u9996\u5148\u9610\u8ff0\u4e86\u5c0f\u5206\u5b50\u8367\u5149\u63a2\u9488\u5728\u764c\u7ec6\u80de\u4e2d\u4f20\u611f\u548c\u6210\u50cf\u7684\u4f18\u52bf\uff0c\u4ee5\u53ca\u5f3a\u8c03\u4e86\u5c0f\u5206\u5b50\u8367\u5149\u63a2\u9488\u5728\u764c\u7ec6\u80de\u9176\u6d3b\u6027\u68c0\u6d4b\u548c\u6210\u50cf\u4e2d\u7684\u5e94\u7528\u548c\u8bbe\u8ba1\u7b56\u7565\u3002\u968f\u540e\uff0c\u4f5c\u8005\u8ba8\u8bba\u4e86\u5c0f\u5206\u5b50\u9176\u8367\u5149\u63a2\u9488\u5728\u4e34\u5e8a\u4e0a\u7684\u5e94\u7528\u548c\u6027\u80fd\uff0c\u5e76\u8fdb\u4e00\u6b65\u91cd\u70b9\u4ecb\u7ecd\u4e86\u8fd9\u4e2a\u65b0\u5174\u9886\u57df\u7684\u6311\u6218\u548c\u673a\u4f1a\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/b><\/strong><\/p>\n

1.<\/b><\/strong>\u5c0f\u5206\u5b50\u9176\u8367\u5149\u63a2\u9488\u7684\u8bbe\u8ba1\u601d\u8def<\/b><\/strong><\/p>\n

\u5927\u591a\u6570\u5c0f\u5206\u5b50\u9176\u8367\u5149\u63a2\u9488\u7684\u8bbe\u8ba1\u662f\u57fa\u4e8e\u4e0e\u9176\u6d3b\u6027\u90e8\u4f4d\u7684\u7279\u5f02\u6027\u4f5c\u7528\uff0c\u6d3b\u6027\u90e8\u4f4d\u5305\u62ec\u50ac\u5316\u4f4d\u70b9\u548c\u7ed3\u5408\u4f4d\u70b9\u3002\u6839\u636e\u63a2\u9488\u4e0e\u9176\u4f5c\u7528\u7684\u673a\u7406\uff0c\u5c0f\u5206\u5b50\u9176\u8367\u5149\u63a2\u9488\u53ef\u5206\u4e3a\u57fa\u4e8e\u5e95\u7269\u7684\u5c0f\u5206\u5b50\u9176\u8367\u5149\u63a2\u9488\u548c\u975e\u57fa\u4e8e\u5e95\u7269\u7684\u5c0f\u5206\u5b50\u9176\u8367\u5149\u63a2\u9488\u3002\u57fa\u4e8e\u5e95\u7269\u7684\u5c0f\u5206\u5b50\u9176\u8367\u5149\u63a2\u9488\u662f\u5c06\u5e95\u7269\u4e0e\u8367\u5149\u56e2\u76f8\u8fde\uff0c\u4e0e\u9176\u4f5c\u7528\u540e\u5149\u8c31\u6027\u8d28\u53d1\u751f\u53d8\u5316\uff1b\u975e\u57fa\u4e8e\u5e95\u7269\u7684\u5c0f\u5206\u5b50\u9176\u8367\u5149\u63a2\u9488\u7531\u4e09\u90e8\u5206\u7ec4\u6210\uff1a\u4ee5\u5171\u4ef7\u65b9\u5f0f\u548c\u975e\u5171\u4ef7\u65b9\u5f0f\u53ef\u4e0e\u9176\u6d3b\u6027\u4f4d\u70b9\u7ed3\u5408\u7684\u57fa\u56e2\uff0c\u8367\u5149\u56e2\u548c\u4e24\u8005\u4e4b\u95f4\u7684\u8fde\u63a5\u7269\u3002<\/p>\n

Figure<\/b><\/strong>\u00a01<\/b><\/strong>.<\/b><\/strong>\u57fa\u4e8e\u5e95\u7269\u7684\u5c0f\u5206\u5b50\u9176\u8367\u5149\u63a2\u9488\u7684\u7ed3\u6784\u4e0e\u673a\u7406<\/b><\/strong><\/p>\n

\"\"<\/p>\n

Figure <\/b><\/strong>2<\/b><\/strong>.<\/b><\/strong>\u975e\u57fa\u4e8e\u5e95\u7269\u7684\u5c0f\u5206\u5b50\u9176\u8367\u5149\u63a2\u9488\u7684\u7ed3\u6784\u4e0e\u673a\u7406<\/b><\/strong><\/p>\n

\"\"<\/p>\n

Figure <\/b><\/strong>3<\/b><\/strong>.\u5171\u4ef7\u7ed3\u5408\u548c\u975e\u5171\u4ef7\u7ed3\u5408\u7684<\/b><\/strong>\u975e\u57fa\u4e8e\u5e95\u7269\u7684\u5c0f\u5206\u5b50\u9176\u8367\u5149\u63a2\u9488<\/b><\/strong><\/p>\n

\"\"<\/p>\n

\u4e3a\u4e86\u4f7f\u8367\u5149\u4fe1\u53f7\uff08\u6ce2\u957f\u6216\u8005\u5f3a\u5ea6\uff09\u5728\u76ee\u6807\u9176\u7684\u4f5c\u7528\u4e0b\u53d1\u751f\u53d8\u5316\uff0c\u591a\u79cd\u4fe1\u53f7\u8f6c\u5316\u673a\u7406\u88ab\u5e94\u7528\u5728\u9176\u63a2\u9488\u4f5c\u7528\u5f53\u4e2d\uff0c\u6bd4\u5982\u5206\u5b50\u5185\u7535\u8377\u8f6c\u79fb(ICT)\u3001\u8367\u5149\u5171\u632f\u80fd\u91cf\u8f6c\u79fb(FRET)\u3001\u6fc0\u53d1\u6001\u5206\u5b50\u5185\u8d28\u5b50\u8f6c\u79fb(ESIPT)\u3001\u5149\u81f4\u7535\u5b50\u8f6c\u79fb(PET)\u3001\u7ed3\u6784\u53d8\u5316\u548c\u5206\u5b50\u5185\u8fd0\u52a8\u53d7\u9650\u7b49\u3002<\/p>\n

Figure <\/b><\/strong>4<\/b><\/strong>.\u5c0f\u5206\u5b50\u9176\u8367\u5149\u63a2\u9488\u7684\u54cd\u5e94\u673a\u7406<\/b><\/strong><\/p>\n

\"\"<\/p>\n

2<\/b><\/strong>.<\/b><\/strong>\u5bf9\u78f7\u9178\u9176\u54cd\u5e94\u7684<\/b><\/strong>\u5c0f\u5206\u5b50\u8367\u5149\u63a2\u9488<\/b><\/strong><\/p>\n

\u78f7\u9178\u9176\u662f\u4e00\u7c7b\u53ef\u4ee5\u53bb\u9664\u6838\u9178\u3001\u86cb\u767d\u8d28\u548c\u78b3\u6c34\u5316\u5408\u7269\u7b49\u4e0d\u540c\u57fa\u8d28\u4e2d\u78f7\u9178\u57fa\u56e2\u7684\u4fe1\u53f7\u9176\u3002\u78f7\u9178\u9176\u4f5c\u4e3a\u91cd\u8981\u7684\u5206\u5b50\u5f00\u5173\u53ef\u8c03\u8282\u591a\u79cd\u7ec6\u80de\u4fe1\u53f7\u901a\u8def\u3002\u78f7\u9178\u9176\u7684\u6d3b\u6027\u5f02\u5e38\u4e0e\u764c\u7ec6\u80de\u7684\u589e\u503c\u3001\u5206\u5316\u548c\u8f6c\u79fb\u6709\u5f88\u5927\u7684\u8054\u7cfb\uff0c\u56e0\u800c\u5bf9\u78f7\u9178\u9176\u7684\u5b9e\u65f6\u76d1\u6d4b\u5728\u764c\u75c7\u8bca\u7597\u65b9\u9762\u6709\u5f88\u91cd\u8981\u7684\u610f\u4e49\u3002<\/p>\n

Figure <\/b><\/strong>5<\/b><\/strong>.\u78b1\u6027\u78f7\u9178\u9176\u8367\u5149\u63a2\u94881-7\u7ed3\u6784<\/b><\/strong><\/p>\n

\"\"<\/p>\n

Figure <\/b><\/strong>6<\/b><\/strong>. \u78b1\u6027\u78f7\u9178\u9176\u8367\u5149\u63a2\u94888-10\u7ed3\u6784<\/b><\/strong><\/p>\n

\"\"<\/p>\n

Figure <\/b><\/strong>7<\/b><\/strong>. \u8367\u5149\u63a2\u948811\u7684\u7ed3\u6784\uff0c\u4ee5\u53ca\u5bf9\u78b1\u6027\u78f7\u9178\u9176\u7684\u68c0\u6d4b\u539f\u7406\u4e0e\u6210\u50cf<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a).\u8367\u5149\u63a2\u948811\u7684\u7ed3\u6784\uff0c\u4ee5\u53ca\u5bf9\u78b1\u6027\u78f7\u9178\u9176\u7684\u68c0\u6d4b\u539f\u7406<\/p>\n

(b,c).\u8367\u5149\u63a2\u9488\u7684\u6eb6\u6db2\u6001\u68c0\u6d4b\u56fe<\/p>\n

(d).\u7ec6\u80de\u6210\u50cf<\/p>\n

Figure <\/b><\/strong>8<\/b><\/strong>.\u8367\u5149\u63a2\u948812\u7684\u7ed3\u6784<\/b><\/strong><\/p>\n

\"\"<\/p>\n

3.\u5bf9\u7fa7\u9178\u916f\u6c34\u89e3\u9176\u54cd\u5e94\u7684<\/b><\/strong>\u5c0f\u5206\u5b50\u8367\u5149\u63a2\u9488<\/b><\/strong><\/p>\n

Figure <\/b><\/strong>9.<\/b><\/strong>\u8367\u5149\u63a2\u948813-23\u7684\u7ed3\u6784<\/b><\/strong><\/p>\n

\"\"<\/p>\n

4.\u5bf9\u9170\u86cb\u767d\u786b\u916f\u9176\u54cd\u5e94\u7684<\/b><\/strong>\u5c0f\u5206\u5b50\u8367\u5149\u63a2\u9488<\/b><\/strong><\/p>\n

Figure <\/b><\/strong>10.<\/b><\/strong>\u00a0\u8367\u5149\u63a2\u948824-25\u7684\u7ed3\u6784<\/b><\/strong><\/p>\n

\"\"<\/p>\n

5.\u5bf9\u7cd6\u82f7\u9176\u54cd\u5e94\u7684\u5c0f\u5206\u5b50\u8367\u5149\u63a2\u9488<\/b><\/strong><\/p>\n

\u7cd6\u57fa\u5316\u4fee\u9970\u53ef\u4ee5\u53d1\u751f\u5728\u7ec6\u80de\u7684\u86cb\u767d\u8868\u8fbe\u3001\u65b0\u9648\u4ee3\u8c22\u3001\u529f\u80fd\u7b49\u65b9\u65b9\u9762\u9762\uff0c\u800c\u7cd6\u57fa\u5316\u7684\u5f02\u5e38\u4e5f\u53ef\u8ba4\u4e3a\u662f\u764c\u7ec6\u80de\u7684\u7279\u70b9\uff0c\u56e0\u6b64\u7cd6\u82f7\u9176\u662f\u5341\u5206\u91cd\u8981\u7684\u764c\u7ec6\u80de\u6807\u8bb0\u7269\u3002<\/p>\n

Figure <\/b><\/strong>11.<\/b><\/strong>\u8367\u5149\u63a2\u948826-36\u7684\u7ed3\u6784<\/b><\/strong><\/p>\n

\"\"<\/p>\n

Figure <\/b><\/strong>12<\/b><\/strong>.\u5bf9\u7cd6\u82f7\u9176\u54cd\u5e94\u7684\u8367\u5149\u63a2\u948837\u548c38\u7684\u7ed3\u6784\u548c\u8367\u5149\u6210\u50cf<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a).\u8367\u5149\u63a2\u948837\u548c38\u7684\u7ed3\u6784<\/p>\n

(b).\u8367\u5149\u6210\u50cf<\/p>\n

Figure <\/b><\/strong>13<\/b><\/strong>.\u8367\u5149\u63a2\u948839-42\u7684\u7ed3\u6784<\/b><\/strong><\/p>\n

\"\"<\/p>\n

6.\u5bf9\u86cb\u767d\u9176\u54cd\u5e94\u7684\u5c0f\u5206\u5b50\u8367\u5149\u63a2\u9488<\/b><\/strong><\/p>\n

Figure <\/b><\/strong>14<\/b><\/strong>.\u5bf9\u4eae\u6c28\u9178\u6c28\u80bd\u9176\u54cd\u5e94\u7684\u8367\u5149\u63a2\u9488<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a).\u8367\u5149\u63a2\u948843\u548c44\u7684\u5316\u5b66\u7ed3\u6784<\/p>\n

(b).\u4eae\u6c28\u9178\u6c28\u80bd\u9176\u7684\u9176\u8c31\u5206\u6790<\/p>\n

(c).\u7ec6\u80de\u63d0\u53d6\u7269\u4e2d\u5b58\u5728\u6d3b\u8dc3\u7684\u4eae\u6c28\u9178\u6c28\u80bd\u9176<\/p>\n

Figure <\/b><\/strong>15<\/b><\/strong>.\u8367\u5149\u63a2\u948845-51\u7684\u7ed3\u6784<\/b><\/strong><\/p>\n

\"\" \"\"<\/p>\n

Figure<\/b><\/strong>\u00a016<\/b><\/strong>.\u5bf9\u6c28\u80bd\u9176N\u54cd\u5e94\u7684\u8367\u5149\u63a2\u948852-55\u7684\u7ed3\u6784<\/b><\/strong><\/p>\n

\"\"<\/p>\n

Figure <\/b><\/strong>17<\/b><\/strong>.\u5bf9DPPIV\u548cFAP\u54cd\u5e94\u7684\u8367\u5149\u63a2\u948856-62\u7684\u7ed3\u6784<\/b><\/strong><\/p>\n

\"\"<\/p>\n

Figure <\/b><\/strong>18<\/b><\/strong>.\u8367\u5149\u63a2\u948863-65\u7684\u7ed3\u6784<\/b><\/strong><\/p>\n

\"\"<\/p>\n

Figure <\/b><\/strong>19<\/b><\/strong>.<\/b><\/strong>\u8367\u5149\u63a2\u948865\u5728\u80bf\u7624\u7ec4\u7ec7\u4e2d\u7684\u53cc\u5149\u5b50\u6210\u50cf<\/b><\/strong><\/p>\n

\"\"<\/p>\n

Figure <\/b><\/strong>20<\/b><\/strong>.\u8367\u5149\u63a2\u948866-71\u7684\u7ed3\u6784<\/b><\/strong><\/p>\n

\"\"<\/p>\n

Figure <\/b><\/strong>21<\/b><\/strong>.\u8367\u5149\u63a2\u948872-75\u7684\u7ed3\u6784<\/b><\/strong><\/p>\n

\"\"<\/p>\n

Figure <\/b><\/strong>22<\/b><\/strong>.\u8367\u5149\u63a2\u948872-75\u5728MCF-7\u7ec6\u80de\u4e2d\u5bf9caspase-3\u7684\u6210\u50cf<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a-c).\u8367\u5149\u63a2\u948872\u5728\u6b63\u5e38\u7684MCF-7\u7ec6\u80de\u4e2d<\/p>\n

(d-f).\u8367\u5149\u63a2\u948872\u5728\u51cb\u4ea1\u7684MCF-7\u7ec6\u80de\u4e2d<\/p>\n

(g-i).\u8367\u5149\u63a2\u948872\u5728\u51cb\u4ea1\u7684MCF-7\u7ec6\u80de\u4e2d\uff0c\u7528\u6291\u5236\u5242\u548ccaspase\u6297\u4f53\u5904\u7406\u540e\u7684\u6210\u50cf<\/p>\n

Figure <\/b><\/strong>23<\/b><\/strong>.\u8367\u5149\u63a2\u948876-78\u7684\u7ed3\u6784<\/b><\/strong><\/p>\n

\"\"<\/p>\n

Figure <\/b><\/strong>24<\/b><\/strong>.\u8367\u5149\u63a2\u948879-82\u7684\u7ed3\u6784<\/b><\/strong><\/p>\n

\"\"<\/p>\n

Figure <\/b><\/strong>25<\/b><\/strong>.\u8367\u5149\u63a2\u948883-86\u7684\u7ed3\u6784<\/b><\/strong><\/p>\n

\"\"<\/p>\n

Figure <\/b><\/strong>26<\/b><\/strong>.\u8367\u5149\u63a2\u948887-89\u7684\u7ed3\u6784<\/b><\/strong><\/p>\n

\"\"<\/p>\n

Figure <\/b><\/strong>27<\/b><\/strong>.\u8367\u5149\u63a2\u948890\u5bf9CatB\u7684\u8367\u5149\u54cd\u5e94\u548c\u7ec6\u80de\u6210\u50cf<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a).\u8367\u5149\u63a2\u948890\u5bf9CatB\u7684\u54cd\u5e94\u673a\u7406<\/p>\n

(b).\u8367\u5149\u63a2\u948890\u5728MDA-MB-231\u7ec6\u80de\u4e2d\u7684\u6210\u50cf<\/p>\n

Figure <\/b><\/strong>28<\/b><\/strong>.CatB\u53ef\u6fc0\u6d3b\u7684\u8bca\u7597\u63a2\u948891\u548c92\u7684\u5316\u5b66\u7ed3\u6784<\/b><\/strong><\/p>\n

\"\"<\/p>\n

Figure <\/b><\/strong>29<\/b><\/strong>.\u8367\u5149\u63a2\u948893-96\u7684\u7ed3\u6784<\/b><\/strong><\/p>\n

\"\"<\/p>\n

Figure <\/b><\/strong>30<\/b><\/strong>.\u8367\u5149\u63a2\u948897-103\u7684\u7ed3\u6784<\/b><\/strong><\/p>\n

\"\"<\/p>\n

Figure <\/b><\/strong>31<\/b><\/strong>.\u8367\u5149\u63a2\u9488104-107\u7684\u7ed3\u6784<\/b><\/strong><\/p>\n

\"\"<\/p>\n

Figure <\/b><\/strong>32<\/b><\/strong>.\u8367\u5149\u63a2\u9488108-111\u7684\u7ed3\u6784<\/b><\/strong><\/p>\n

\"\"<\/p>\n

7.\u5bf9\u6c27\u5316\u8fd8\u539f\u9176\u54cd\u5e94\u7684\u5c0f\u5206\u5b50\u8367\u5149\u63a2\u9488<\/b><\/strong><\/p>\n

Figure <\/b><\/strong>33<\/b><\/strong>.\u8367\u5149\u63a2\u9488112-116\u7684\u7ed3\u6784<\/b><\/strong><\/p>\n

\"\"<\/p>\n

Figure <\/b><\/strong>34<\/b><\/strong>.\u8367\u5149\u63a2\u9488116\u5bf9\u7edc\u6c28\u9178\u9176\u7684\u7ec6\u80de\u6210\u50cf<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a).\u8367\u5149\u63a2\u9488116\u5728\u4e0d\u540c\u65f6\u95f4\u4e0d\u540c\u7ec6\u80de\u4e2d\u7684\u8367\u5149\u6210\u50cf<\/p>\n

(b).\u7ec6\u80de\u4e2d\u8367\u5149\u5f3a\u5ea6\u968f\u65f6\u95f4\u7684\u53d8\u5316<\/p>\n

(c).\u7edc\u6c28\u9178\u9176\u5728\u4e0d\u540c\u7ec6\u80de\u4e2d\u7684\u6d3b\u6027<\/p>\n

Figure <\/b><\/strong>35<\/b><\/strong>.\u8367\u5149\u63a2\u9488117-123\u7684\u7ed3\u6784<\/b><\/strong><\/p>\n

\"\"<\/p>\n

Figure <\/b><\/strong>36<\/b><\/strong>.\u8367\u5149\u63a2\u9488124-133\u7684\u7ed3\u6784<\/b><\/strong><\/p>\n

\"\"<\/p>\n

Figure <\/b><\/strong>37<\/b><\/strong>.\u8367\u5149\u63a2\u9488129\u7684\u5c0f\u9f20\u80bf\u7624\u6210\u50cf<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a,b).\u8367\u5149\u63a2\u9488129\u5728\u6ce8\u5165\u5c0f\u9f20\u524d\u540e\u7684\u8367\u5149\u6210\u50cf<\/p>\n

(c).\u5c0f\u9f20\u4f53\u5185\u8367\u5149\u5f3a\u5ea6\u968f\u65f6\u95f4\u7684\u53d8\u5316<\/p>\n

Figure <\/b><\/strong>38<\/b><\/strong>.\u8367\u5149\u63a2\u9488134-136\u7684\u7ed3\u6784<\/b><\/strong><\/p>\n

\"\"<\/p>\n

Figure <\/b><\/strong>39<\/b><\/strong>.\u8367\u5149\u63a2\u9488137-142\u7684\u7ed3\u6784<\/b><\/strong><\/p>\n

\"\"<\/p>\n

Figure <\/b><\/strong>40<\/b><\/strong>.\u8367\u5149\u63a2\u9488143-146\u7684\u7ed3\u6784<\/b><\/strong><\/p>\n

\"\"<\/p>\n

Figure <\/b><\/strong>41<\/b><\/strong>.\u8367\u5149\u63a2\u9488144\u5bf9COX-2\u7684\u54cd\u5e94<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a).\u8367\u5149\u63a2\u9488144\u4e0eCOX-2\u4f5c\u7528\u524d\u540e\u7684\u8367\u5149\u5149\u8c31<\/p>\n

(b).\u80bf\u7624\u8367\u5149\u7167\u7247<\/p>\n

Figure <\/b><\/strong>42<\/b><\/strong>.\u8367\u5149\u63a2\u9488147-148\u7684\u7ed3\u6784<\/b><\/strong><\/p>\n

\"\"<\/p>\n

Figure <\/b><\/strong>43<\/b><\/strong>.\u8367\u5149\u63a2\u9488149-150\u7684\u7ed3\u6784<\/b><\/strong><\/p>\n

\"\"<\/p>\n

Figure <\/b><\/strong>44<\/b><\/strong>.\u8367\u5149\u63a2\u9488151-155\u7684\u7ed3\u6784<\/b><\/strong><\/p>\n

\"\"<\/p>\n

7.\u5bf9\u8f6c\u79fb\u9176\u54cd\u5e94\u7684\u5c0f\u5206\u5b50\u8367\u5149\u63a2\u9488<\/b><\/strong><\/p>\n

Figure <\/b><\/strong>45<\/b><\/strong>.\u8367\u5149\u63a2\u9488145\u5bf9GGT\u7684\u54cd\u5e94<\/b><\/strong><\/p>\n

\"\"<\/p>\n

Figure <\/b><\/strong>46<\/b><\/strong>.\u8367\u5149\u63a2\u9488157-168\u7684\u7ed3\u6784<\/b><\/strong><\/p>\n

\"\"<\/p>\n

Figure <\/b><\/strong>47<\/b><\/strong>.\u8367\u5149\u63a2\u9488169-175\u7684\u7ed3\u6784<\/b><\/strong><\/p>\n

\"\"<\/p>\n

8.\u5c0f\u5206\u5b50\u8367\u5149\u63a2\u9488\u5728\u4e34\u5e8a\u4e0a\u7684\u5e94\u7528<\/b><\/strong><\/p>\n

\u764c\u75c7\u624b\u672f\u4e2d\u7684\u5149\u5b66\u6210\u50cf\u663e\u5f71\u5242\u662f\u5c0f\u5206\u5b50\u8367\u5149\u63a2\u9488\u5728\u4e34\u5e8a\u4e0a\u6700\u5f15\u4eba\u6ce8\u76ee\u7684\u5e94\u7528\u3002\u5bf9\u4e8e\u764c\u75c7\u6cbb\u7597\u4e2d\u7684\u624b\u672f\u4ecb\u5165\uff0c\u6700\u5927\u7684\u6311\u6218\u662f\u786e\u5b9a\u80bf\u7624\u548c\u6b63\u5e38\u7ec4\u7ec7\u95f4\u7684\u8fb9\u754c\u3002\u8367\u5149\u6210\u50cf\u5728\u6b64\u9886\u57df\u4e2d\u5df2\u7ecf\u53d6\u5f97\u4e86\u91cd\u5927\u7684\u53d1\u5c55\u3002<\/p>\n

Figure <\/b><\/strong>48<\/b><\/strong>.\u5e94\u7528\u5728\u533b\u5b66\u9886\u57df\u4e2d\u7684\u8367\u5149\u63a2\u9488\u7ed3\u6784<\/b><\/strong><\/p>\n

\"\"<\/p>\n

Figure <\/b><\/strong>49<\/b><\/strong>.\u53cc\u6a21\u6001\u6210\u50cf\u63a2\u9488\u7684\u7ed3\u6784<\/b><\/strong><\/p>\n

\"\"<\/p>\n

\u3010\u7ed3\u8bba\u4e0e\u5c55\u671b\u3011<\/b><\/strong><\/p>\n

\u5728\u8fc7\u53bb\u7684\u51e0\u5341\u5e74\u4e2d\uff0c\u5c0f\u5206\u5b50\u9176\u8367\u5149\u63a2\u9488\u5df2\u7ecf\u5728\u764c\u75c7\u6210\u50cf\u4e2d\u53d6\u5f97\u4e86\u5341\u5206\u77a9\u76ee\u7684\u53d1\u5c55\u3002\u5c0f\u5206\u5b50\u9176\u8367\u5149\u63a2\u9488\u53ef\u5bf9\u764c\u7ec6\u80de\u4e2d\u7684\u9176\u8fdb\u884c\u68c0\u6d4b\u548c\u6210\u50cf\uff0c\u4e3a\u764c\u75c7\u7684\u8bca\u65ad\u548c\u6cbb\u7597\u63d0\u4f9b\u4e86\u4e00\u4e2a\u5f3a\u5927\u7684\u65b9\u6cd5\u3002\u5728\u8fd9\u7bc7\u7efc\u8ff0\u4e2d\uff0c\u4f5c\u8005\u603b\u7ed3\u4e86\u8fd9\u4e2a\u65b0\u5174\u9886\u57df\u7684\u6700\u65b0\u53d1\u5c55\uff0c\u5305\u62ec\u5c0f\u5206\u5b50\u9176\u8367\u5149\u63a2\u9488\u7684\u8bbe\u8ba1\u7b56\u7565\u3001\u764c\u7ec6\u80de\u4e2d\u9176\u6d3b\u6027\u7684\u68c0\u6d4b\u548c\u6210\u50cf\uff0c\u4ee5\u53ca\u4e34\u5e8a\u4e0a\u7684\u5e94\u7528\u3002<\/p>\n

\u5c3d\u7ba1\u5c0f\u5206\u5b50\u9176\u8367\u5149\u63a2\u9488\u5df2\u7ecf\u5728\u764c\u75c7\u6210\u50cf\u4e2d\u53d6\u5f97\u4e86\u663e\u8457\u7684\u53d1\u5c55\uff0c\u4e00\u4e9b\u6311\u6218\u4f9d\u7136\u5b58\u5728\uff0c\u6bd4\u5982\u5982\u4f55\u5c06\u79d1\u7814\u6210\u679c\u8f6c\u5316\u6210\u5b9e\u9645\u4e34\u5e8a\u5e94\u7528\u3002\u9996\u5148\uff0c\u56e0\u4e3a\u9176\u5728\u764c\u75c7\u65e9\u671f\u8bca\u65ad\u4e2d\u8f83\u4f4e\u7684\u4e30\u5ea6\uff0c\u8367\u5149\u63a2\u9488\u7684\u7075\u654f\u5ea6\u548c\u9009\u62e9\u6027\u9700\u8981\u63d0\u9ad8\uff1b\u5176\u6b21\uff0c\u4e3a\u4e86\u66f4\u597d\u5730\u8fdb\u884c\u4f53\u5185\u6210\u50cf\uff0c\u9700\u8981\u5f00\u53d1\u7ea2\u5916\u63a2\u9488\u548c\u53cc\u5149\u5b50\u63a2\u9488\uff0c\u964d\u4f4e\u8367\u5149\u80cc\u666f\u4fe1\u53f7\u548c\u63d0\u9ad8\u6210\u50cf\u7a7f\u900f\u6df1\u5ea6\uff1b\u6700\u540e\uff0c\u9700\u8981\u5b9e\u73b0\u9176\u6d3b\u6027\u7684\u5b9a\u91cf\u68c0\u6d4b\u3002<\/p>\n

Recent Progresses in Small-Molecule Enzymatic Fluorescent Probes for Cancer Imaging<\/a><\/p>\n

\u00a0(Chem. Soc. Rev., 2018, DOI: 10. 1039\/c7cs00862g)<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u5b66\u672f\u7ec4gaxy\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u6574\u7406\u7f16\u8f91\u3002 \u00a0<\/p>\n

\u6750\u6599\u725b\u7f51\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1tougao@cailiaoren.com\u3002<\/p>\n

\u6295\u7a3f\u4ee5\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1acailiaokefu\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u3010\u5f15\u8a00\u3011 \u6839\u636eWHO\u516c\u5e03\u7684\u6570\u636e\uff0c\u52302035\u5e74\uff0c\u5168\u7403\u5c06\u4f1a\u4ea7\u751f2400\u4e07\u4e2a\u764c\u75c7\u65b0\u75c5\u4f8b\u4ee5\u53ca1450\u4e07\u4e2a\u764c\u75c7\u76f8\u5173\u6b7b\u4ea1\u3002\u5728\u8fd9\u4e9b\u764c\u75c7\u76f8\u5173\u7684\u6b7b\u4ea1\u4e2d\uff0c\u6709\u5927\u7ea630%\u7684\u60a3\u8005\u662f\u53ef\u4ee5\u901a…<\/p>\n","protected":false},"author":7336,"featured_media":153811,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[533],"tags":[2939],"class_list":["post-153707","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-zongshu","tag-2939"],"_links":{"self":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/153707"}],"collection":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/users\/7336"}],"replies":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=153707"}],"version-history":[{"count":2,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/153707\/revisions"}],"predecessor-version":[{"id":153865,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/153707\/revisions\/153865"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/media\/153811"}],"wp:attachment":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=153707"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=153707"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=153707"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}