{"id":158230,"date":"2018-11-09T06:41:25","date_gmt":"2018-11-08T22:41:25","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=158230"},"modified":"2018-11-08T09:42:21","modified_gmt":"2018-11-08T01:42:21","slug":"%e5%8d%97%e6%b4%8b%e7%90%86%e5%b7%a5%e5%a4%a7%e5%ad%a6nat-commun-%e8%87%aa%e6%a4%8d%e5%85%a5%e7%9a%84%e5%8f%8c%e5%b1%82%e5%be%ae%e7%b1%b3%e7%ba%a7%e8%8d%af%e7%89%a9%e5%ba%93%e7%94%a8%e4%ba%8e","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=158230","title":{"rendered":"\u5357\u6d0b\u7406\u5de5\u5927\u5b66Nat. Commun.: 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double-layered micro-drug-reservoirs for efficient and controlled ocular drug delivery<\/b><\/strong>\u201d\u7684\u6587\u7ae0\uff0c\u6587\u4e2d\u4f5c\u8005\u8bbe\u8ba1\u4e86\u4e00\u79cd\u67d4\u6027\u7684\u805a\u5408\u7269\u773c\u90e8\u8d34\u7247\uff0c\u7531\u4e00\u7cfb\u5217\u53ef\u751f\u7269\u964d\u89e3\u548c\u53ef\u5206\u79bb\u7684\u5fae\u9488\u7ec4\u6210\uff0c\u7528\u4e8e\u5c40\u90e8\u9ad8\u6548\u548c\u53ef\u63a7\u7684\u773c\u90e8\u836f\u7269\u91ca\u653e\u3002\u5fae\u9488\u53ef\u4ee5\u7a7f\u900f\u773c\u90e8\u5c4f\u969c\uff08\u89d2\u819c\u4e0a\u76ae\u548c\u57fa\u8d28\u5c42\uff09\uff0c\u5177\u6709\u6700\u5c0f\u7684\u4fb5\u88ad\u6027\uff0c\u53ef\u4ee5\u81ea\u690d\u5165\u4f5c\u4e3a\u836f\u7269\u5e93\u7528\u4e8e\u53ef\u63a7\u7684\u836f\u7269\u91ca\u653e\u3002\u53cc\u5c42\u7ed3\u6784\u7684\u5fae\u9488\u5141\u8bb8\u5feb\u901f\u548c\u7f13\u6162\u7684\u53cc\u76f8\u91ca\u653e\u52a8\u529b\u5b66\u548c\u591a\u79cd\u836f\u7269\u7684\u5305\u88c5\u4ece\u800c\u7528\u4e8e\u534f\u540c\u6cbb\u7597\u3002\u4f53\u5185\u5b9e\u9a8c\u8bc1\u660e\uff0c\u4e0e\u5c40\u90e8\u6ef4\u773c\u6db2\u548c\u5feb\u901f\u836f\u7269\u91ca\u653e\u65b9\u6cd5\u76f8\u6bd4\uff0c\u8fd9\u79cd\u773c\u90e8\u8d34\u7247\u5728\u6cbb\u7597\u89d2\u819c\u65b0\u751f\u8840\u7ba1\u65b9\u9762\u5177\u6709\u5353\u6548\u6cbb\u7597\u6548\u679c\u3002<\/p>\n<p><strong><b>\u3010\u56fe\u6587\u7b80\u4ecb\u3011<\/b><\/strong><\/p>\n<p><strong><b>\u56fe\u4e00\uff1a\u773c\u90e8\u8d34\u7247\u7528\u4e8e\u773c\u90e8\u91ca\u653e\u836f\u7269\u7684\u793a\u610f\u56fe<\/b><\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-158246 size-full aligncenter\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/11\/\u56fe\u724726.png\" alt=\"\" width=\"554\" height=\"146\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/11\/\u56fe\u724726.png 554w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/11\/\u56fe\u724726-300x79.png 300w\" sizes=\"(max-width: 554px) 100vw, 554px\" \/><\/p>\n<p>\u8be5\u773c\u90e8\u8d34\u7247\u662f\u7531\u4e00\u7cfb\u5217\u53ef\u81ea\u690d\u5165\u7684\u5fae\u7c73\u7ea7\u836f\u7269\u5e93\u7ec4\u6210\u3002<\/p>\n<p><strong><b>\u56fe\u4e8c\uff1a\u805a\u5408\u7269\u773c\u90e8\u8d34\u7247\u7684\u5236\u5907\u793a\u610f\u56fe<\/b><\/strong><\/p>\n<p><strong><b>\u00a0<img loading=\"lazy\" decoding=\"async\" class=\"wp-image-158247 size-full aligncenter\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/11\/\u56fe\u724727.png\" alt=\"\" width=\"650\" height=\"279\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/11\/\u56fe\u724727.png 650w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/11\/\u56fe\u724727-300x129.png 300w\" sizes=\"(max-width: 650px) 100vw, 650px\" \/><\/b><\/strong><\/p>\n<p>\u8be5\u773c\u90e8\u8d34\u7247\u662f\u7531\u4e00\u7cfb\u5217\u9488\u72b6\u7684\u53cc\u5c42\u5fae\u7c73\u7ea7\u836f\u7269\u5e93\u7ec4\u6210\u3002<\/p>\n<p><strong><b>\u56fe\u4e09\uff1a\u53cc\u5c42\u5fae\u9488\u7684\u8868\u5f81<\/b><\/strong><\/p>\n<p><strong><b>\u00a0<img loading=\"lazy\" decoding=\"async\" class=\"wp-image-158248 size-full aligncenter\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/11\/\u56fe\u724728.png\" alt=\"\" width=\"554\" height=\"269\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/11\/\u56fe\u724728.png 554w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/11\/\u56fe\u724728-300x146.png 300w\" sizes=\"(max-width: 554px) 100vw, 554px\" \/><\/b><\/strong><\/p>\n<p><strong><b>\u00a0<\/b><\/strong>a\uff0cb\uff09\u805a\u5408\u7269\u5fae\u9488\u8d34\u7247\u7684\u793a\u610f\u56fe\u53caSEM\u56fe\uff08\u5916\u5c42\u662f\u7531\u4ea4\u8054\u4e86\u7684MeHA\u7ec4\u6210\uff0c\u5185\u90e8\u662f\u7531\u00a0HA\u7ec4\u6210\uff0c\u6bd4\u4f8b\u5c3a\u662f100 \u03bcm\u3002<\/p>\n<p>c-e\uff09\u00a0\u5171\u805a\u7126\u663e\u5fae\u955c\u56fe\uff1ac\uff09\u8d1f\u8f7d\u6709\u5916\u5c42\u7684Alexa Fluor: IgG(680)\uff08\u7ea2\u8272\uff09\u548c\u5185\u90e8\u7684IgG(488)\uff08\u7eff\u8272\uff09\u4e0e\u514d\u75ab\u7403\u86cb\u767dG\u7ed3\u5408\u7684\u53cc\u5c42\u5fae\u9488\uff1bd\uff09\u53ea\u6709\u5916\u5c42Alexa Fluor: IgG(680)\uff08\u7ea2\u8272\uff09\u7684\u53cc\u5c42\u5fae\u9488\uff1be\uff09\u53ea\u6709\u5185\u90e8IgG(488)\uff08\u7eff\u8272\uff09\u7684\u53cc\u5c42\u5fae\u9488\u3002\u6bd4\u4f8b\u5c3a\u662f100 \u03bcm\u3002<\/p>\n<p>f\uff09 \u53cc\u5c42\u5fae\u9488\u5728\u6a21\u62df\u773c\u6cea\u548c\u660e\u80f6\u6c34\u51dd\u80f6\uff0837 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\/>\u00a0<\/b><\/strong><strong><b>\u00a0<\/b><\/strong>a\uff09\u53cc\u5c42\u5fae\u9488\u5728\u743c\u8102\u7cd6\u51dd\u80f6\u4e2d\u7684\u91ca\u653e\u793a\u610f\u56fe\u3002<\/p>\n<p>\u00a0b\uff09\u53cc\u5c42\u5fae\u9488\u5728\u743c\u8102\u7cd6\u51dd\u80f6\u4e2d\u4e0d\u540c\u65f6\u95f4 \uff083\u00a0min-6 h\uff09\u7684\u5149\u5b66\u548c\u8367\u5149\u56fe\u50cf\u3002\u6bd4\u4f8b\u5c3a\u662f200 \u03bcm\u3002<\/p>\n<p><strong><b>\u56fe\u4e94\uff1a\u53cc\u5c42\u5fae\u9488\u5728\u732a\u7684\u89d2\u819c\u4e2d\u7684\u7814\u7a76<\/b><\/strong><\/p>\n<p><strong><b>\u00a0<img loading=\"lazy\" decoding=\"async\" class=\"wp-image-158252 size-full aligncenter\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/11\/\u56fe\u724730.png\" alt=\"\" width=\"554\" height=\"432\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/11\/\u56fe\u724730.png 554w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/11\/\u56fe\u724730-300x234.png 300w\" sizes=\"(max-width: 554px) 100vw, 554px\" \/><\/b><\/strong>a\uff0cb\uff09\u89d2\u819c\u5728\u63d2\u9488\u4e4b\u524d\u548c\u4e4b\u540e\u7684\u4eae\u573a\u56fe\u50cf\u3002\u6bd4\u4f8b\u5c3a\u662f2 mm\u3002<\/p>\n<p>c\uff0cd\uff09\u89d2\u819c\u5728\u63d2\u9488\u4e4b\u524d\u548c\u4e4b\u540e\u79fb\u9664\u6389\u652f\u6491\u90e8\u5206\u7684\u6a2a\u622a\u9762\u4eae\u573a\u56fe\u50cf\u3002\u6bd4\u4f8b\u5c3a\u662f200 \u03bcm\u3002<\/p>\n<p>e\uff09\u89d2\u819c\u7684\u82cf\u6728\u7cbe\u4f0a\u7ea2\u67d3\u8272\u533a\u57df\uff0c\u5176\u4e2d\u7684\u7a7a\u7a74\u662f\u7531\u4e8e\u53cc\u5c42\u5fae\u9488\u7684\u63d2\u5165\u3002\u6bd4\u4f8b\u5c3a\u662f100 \u03bcm\u3002<\/p>\n<p>f\uff09\u53cc\u5c42\u5fae\u9488\u63d2\u5165\u89d2\u819c\u7684\u5e73\u5747\u63d2\u5165\u529b\u3002<\/p>\n<p>g-i\uff09\u53cc\u5c42\u5fae\u9488\u5d4c\u5165\u89d2\u819c\u7684\u5171\u805a\u7126\u663e\u5fae\u955c\u56fe\u3002\u6bd4\u4f8b\u5c3a\u662f100 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double-layered micro-drug-reservoirs for efficient and controlled ocular drug delivery (Nat. Commun. 2018,)<\/p>\n<p>\u672c\u6587\u7531\u4f5c\u8005\u56e2\u961f\u4f9b\u7a3f\uff0c\u6750\u6599\u4eba\u7f16\u8f91\u90e8\u7f16\u8f91\u3002<\/p>\n<p>\u6295\u7a3f\u4ee5\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1acailiaorenvip\u3002<\/p>\n<p>\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1tougao@cailiaoren.com\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u5f15\u8a00\u3011 \u773c\u90e8\u75be\u75c5\u00a0\uff08\u9752\u5149\u773c\u3001\u7cd6\u5c3f\u75c5\u89c6\u7f51\u819c\u75c5\u53d8\u3001\u5e74\u9f84\u76f8\u5173\u6027\u9ec4\u6591\u53d8\u6027\u7b49\uff09\u5728\u5168\u4e16\u754c\u8303\u56f4\u5185\u5df2\u7ecf\u5f15\u8d77\u4e86\u4e25\u91cd\u7684\u4e34\u5e8a\u95ee\u9898\u3002\u7136\u800c\uff0c\u7531\u4e8e\u5b58\u5728\u591a\u4e2a\u7ed3\u6784\u969c\u788d\uff08\u4f8b\u5982\u89d2\u819c\u4e0a\u76ae\u548c\u8840\u6db2-\u89c6&#8230;<\/p>\n","protected":false},"author":10213,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215],"tags":[],"class_list":["post-158230","post","type-post","status-publish","format-standard","hentry","category-jiedu"],"_links":{"self":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/158230"}],"collection":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/users\/10213"}],"replies":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=158230"}],"version-history":[{"count":2,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/158230\/revisions"}],"predecessor-version":[{"id":158269,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/158230\/revisions\/158269"}],"wp:attachment":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=158230"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=158230"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=158230"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}