{"id":158245,"date":"2018-11-10T06:30:57","date_gmt":"2018-11-09T22:30:57","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=158245"},"modified":"2018-11-09T15:51:19","modified_gmt":"2018-11-09T07:51:19","slug":"%e5%8d%8e%e5%8d%97%e7%90%86%e5%b7%a5%e5%a4%a7%e5%ad%a6acc-chem-res-%e7%bb%bc%e8%bf%b0-%e5%9f%ba%e4%ba%8e%e8%82%bf%e7%98%a4%e9%85%b8%e5%ba%a6%e5%93%8d%e5%ba%94%e7%9a%84%e9%a9%ac%e6%9d%a5%e9%85%b8","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=158245","title":{"rendered":"\u534e\u5357\u7406\u5de5\u5927\u5b66Acc. Chem. Res.\u7efc\u8ff0: \u57fa\u4e8e\u80bf\u7624\u9178\u5ea6\u54cd\u5e94\u7684\u9a6c\u6765\u9178\u9170\u80fa\u7528\u4e8e\u764c\u75c7\u667a\u80fd\u8f7d\u836f"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/b><\/strong><\/p>\n

\u7eb3\u7c73\u836f\u7269\u56e0\u4e3a\u53ef\u4ee5\u5728\u80bf\u7624\u533a\u57df\u9009\u62e9\u6027\u5730\u5bcc\u96c6\uff0c\u53d7\u5230\u4e86\u5e7f\u6cdb\u7684\u5173\u6ce8\u3002\u5728\u8fc7\u53bb\u7684\u51e0\u5341\u5e74\u4e2d\uff0c\u79d1\u5b66\u5bb6\u5f00\u53d1\u51fa\u4e86\u5f88\u591a\u79cd\u7eb3\u7c73\u8f7d\u836f\u4f53\u7cfb\u3002\u8fd9\u5176\u4e2d\uff0c\u4e0d\u5c11\u8f7d\u836f\u4f53\u7cfb\u5df2\u7ecf\u53d6\u5f97\u4e86\u4e34\u5e8a\u5e94\u7528\u8d44\u683c\uff0c\u8fd8\u6709\u5f88\u591a\u5728\u4e34\u5e8a\u63a2\u7d22\u9636\u6bb5\u3002\u5c3d\u7ba1\u5982\u6b64\uff0c\u6574\u4f53\u4e0a\u6765\u8bf4\uff0c\u8fd9\u4e9b\u764c\u75c7\u7eb3\u7c73\u836f\u7269\u7684\u6cbb\u7597\u6548\u679c\u5e76\u4e0d\u5c3d\u5982\u4eba\u610f\u3002\u5728\u65e9\u671f\u7684\u7814\u7a76\u4e2d\uff0c\u79d1\u5b66\u5bb6\u8fc7\u5206\u6ce8\u91cd\u63d0\u9ad8\u7eb3\u7c73\u7c92\u5b50\u5728\u80bf\u7624\u90e8\u4f4d\u7684\u5bcc\u96c6\uff0c\u800c\u5ffd\u7565\u4e86\u7eb3\u7c73\u836f\u7269\u7684\u7597\u6548\u5f88\u5927\u7a0b\u5ea6\u4e0a\u662f\u7531\u7eb3\u7c73\u836f\u7269\u4ece\u6ce8\u5c04\u90e8\u4f4d\u5230\u4f5c\u7528\u90e8\u4f4d\u6240\u9700\u8981\u514b\u670d\u7684\u4f20\u9012\u969c\u788d\u6240\u51b3\u5b9a\u7684\u3002\u8fd9\u4e9b\u4f20\u9012\u8fc7\u7a0b\u53ef\u4ee5\u7b80\u8981\u6982\u62ec\u4e3a\u8840\u6db2\u5faa\u73af\u3001\u80bf\u7624\u90e8\u4f4d\u7684\u8840\u7ba1\u6e17\u51fa\u548c\u5bcc\u96c6\u3001\u80bf\u7624\u7ec4\u7ec7\u7684\u6e17\u900f\u3001\u80bf\u7624\u7ec6\u80de\u6444\u53d6\u4ee5\u53ca\u80de\u5185\u836f\u7269\u91ca\u653e\u3002\u56e0\u6b64\uff0c\u9700\u8981\u63d0\u9ad8\u7eb3\u7c73\u7c92\u5b50\u5728\u6bcf\u4e00\u4e2a\u73af\u8282\u7684\u4f20\u9012\u6548\u7387\u3002\u7531\u4e8e\u4e0d\u540c\u9012\u9001\u73af\u8282\u7684\u5fae\u73af\u5883\u90fd\u662f\u4e0d\u4e00\u6837\u7684\uff0c\u56e0\u800c\u5bf9\u4e8e\u7eb3\u7c73\u7c92\u5b50\u800c\u8a00\uff0c\u6bcf\u4e00\u6b65\u7684\u4f18\u5316\u6761\u4ef6\u90fd\u662f\u4e0d\u540c\u7684\uff0c\u751a\u81f3\u662f\u76f8\u4e92\u77db\u76fe\u7684\u3002\u53ef\u4ee5\u8bf4\u6bcf\u4e00\u6b65\u4f20\u9012\u8fc7\u7a0b\u90fd\u4f1a\u4e3a\u7eb3\u7c73\u7c92\u5b50\u7684\u8bbe\u8ba1\u8bbe\u7f6e\u4e00\u4e2a\u969c\u788d\u3002\u4f20\u7edf\u7684\u836f\u7269\u4f20\u9012\u4f53\u7cfb\u867d\u7136\u6709\u4e00\u5b9a\u7684\u4f18\u70b9\uff0c\u5374\u4e0d\u80fd\u540c\u65f6\u514b\u670d\u8fd9\u4e9b\u969c\u788d\u3002\u7406\u60f3\u7684\u836f\u7269\u4f20\u9012\u4f53\u7cfb\u9700\u8981\u6ee1\u8db3\u4f20\u9012\u8fc7\u7a0b\u6bcf\u4e00\u6b65\u7684\u8981\u6c42\uff0c\u5305\u62ec\u6301\u7eed\u5f88\u4e45\u7684\u5faa\u73af\u8fc7\u7a0b\uff0c\u589e\u5f3a\u7684\u8840\u7ba1\u5916\u6e17\u548c\u80bf\u7624\u5bcc\u96c6\uff0c\u9ad8\u6548\u7684\u80bf\u7624\u6e17\u900f\uff0c\u826f\u597d\u7684\u7ec6\u80de\u6444\u53d6\u4ee5\u53ca\u53ef\u63a7\u7684\u7ec6\u80de\u5185\u836f\u7269\u91ca\u653e\u3002<\/p>\n

\u523a\u6fc0\u54cd\u5e94\u7684\u7eb3\u7c73\u7c92\u5b50\u7531\u4e8e\u53ef\u5bf9\u5c40\u90e8\u5fae\u73af\u5883\u54cd\u5e94\uff0c\u53ef\u4ee5\u514b\u670d\u5728\u836f\u7269\u4f20\u9012\u8fc7\u7a0b\u4e2d\u7684\u79cd\u79cd\u969c\u788d\u3002\u5728\u8fd9\u4e9b\u523a\u6fc0\u4e2d\uff0cpH\u54cd\u5e94\u6700\u5e38\u89c1\uff0c\u56e0\u4e3a\u4e0d\u540c\u7684\u7ec4\u7ec7\u548c\u7ec6\u80de\u5668\u90fd\u5177\u6709\u4e0d\u540c\u7684pH\u503c\u3002\u6bd4\u5982\u80bf\u7624\u5fae\u73af\u5883\u4f1a\u6bd4\u8840\u6db2\u66f4\u9178\u6027\uff0c\u800c\u6eb6\u9176\u4f53\u8fd9\u7c7b\u7ec6\u80de\u5668\u4f1a\u66f4\u9178\u6027\u4e00\u4e9b\u3002\u901a\u8fc7\u5229\u7528\u8fd9\u4e9bpH\u53d8\u5316\uff0c\u4e00\u7cfb\u5217\u57fa\u4e8epH\u54cd\u5e94\u7684\u4f20\u9012\u4f53\u7cfb\u88ab\u5f00\u53d1\u51fa\u6765\uff0c\u7528\u4e8e\u514b\u670d\u4f20\u9012\u8fc7\u7a0b\u4e2d\u7684\u969c\u788d\u3002\u7136\u800c\u5f88\u591a\u8fd9\u7c7b\u667a\u80fd\u54cd\u5e94\u4f53\u7cfb\u90fd\u662f\u9488\u5bf9\u7ec6\u80de\u5185pH\u54cd\u5e94\u7684\uff0c\u5bf9\u80bf\u7624\u9178\u6027\u73af\u5883\u54cd\u5e94\u7684\u7eb3\u7c73\u836f\u7269\u4f9d\u7136\u8f83\u5c11\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/b><\/strong><\/p>\n

\u534e\u5357\u7406\u5de5\u5927\u5b66\u738b\u5747\u6559\u6388\u3001\u675c\u91d1\u5fd7\u7279\u8058\u7814\u7a76\u5458<\/b><\/strong>\u5728Acc. Chem. Res.<\/b><\/strong>\u4e0a\uff0c\u53d1\u8868\u4e86\u9898\u4e3a”Tumor-Acidity-Cleavable Maleic Acid Amide (TACMAA): A Powerful Tool for Designing Smart Nanoparticles to Overcome Delivery Barriers in Cancer Nanomedicine<\/b><\/strong>“\u7684\u7efc\u8ff0\u3002\u5728\u8fd9\u7bc7\u7efc\u8ff0\u4e2d\uff0c\u4f5c\u8005\u7cfb\u7edf\u5730\u603b\u7ed3\u4e86\u4ed6\u4eec\u56e2\u961f\u5728\u57fa\u4e8eTACMAA\u7684\u7eb3\u7c73\u8f7d\u836f\u4f53\u7cfb\u8bbe\u8ba1\u601d\u60f3\uff0c\u4ee5\u53ca\u5229\u7528TACMAA\u5e2e\u52a9\u7eb3\u7c73\u8f7d\u836f\u4f53\u7cfb\u514b\u670d\u4f20\u9012\u8fc7\u7a0b\u4e2d\u7684\u79cd\u79cd\u969c\u788d\u3002\u8fd9\u7bc7\u7efc\u8ff0\u4e3b\u8981\u5206\u4e3a\u4e94\u4e2a\u90e8\u5206\uff0cTACMAA\u7684\u5316\u5b66\uff0c\u80bf\u7624\u9178\u5ea6\u5f15\u53d1\u7684\u7535\u8377\u53cd\u8f6c\uff0c\u80bf\u7624\u9178\u5ea6\u5f15\u53d1\u7684\u58f3\u5206\u79bb\uff0c\u80bf\u7624\u9178\u5ea6\u5f15\u53d1\u7684\u5c3a\u5bf8\u53d8\u5316\uff0c\u80bf\u7624\u9178\u5ea6\u5f15\u53d1\u7684\u914d\u4f53\u91cd\u6d3b\u5316\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/b><\/strong><\/p>\n

1.<\/b><\/strong>MAA\u5316\u5b66\u57fa\u7840<\/b><\/strong><\/p>\n

\u4e00\u822c\u7684\u9170\u80fa\u952e\u53ea\u4f1a\u5728\u6781\u7aef\u7684\u9178\u6027\u6761\u4ef6\u4e0b\u624d\u4f1a\u964d\u89e3\uff0c\u7136\u800c\uff0cMAA\u884d\u751f\u7269\u7684\u9170\u80fa\u952e\u5728\u6e29\u548c\u7684\u9178\u6027\u73af\u5883\u4e2d\u5c31\u4f1a\u88ab\u5207\u65ad\u3002\u8fd9\u79cd\u589e\u5f3a\u7684pH\u7075\u654f\u5ea6\u4e3b\u8981\u5f52\u7ed3\u4e8e\u90bb\u4f4d\u7684\u7fa7\u57fa\u53ef\u4ee5\u8f7b\u6613\u5730\u8fdb\u653b\u9170\u80fa\u952e\u7684\u7fb0\u57fa\uff0c\u5f62\u6210\u4e94\u5143\u73af\u3002<\/p>\n

2<\/b><\/strong>.<\/b><\/strong>\u80bf\u7624\u9178\u5ea6\u8bf1\u5bfc\u7684\u7535\u8377\u53cd\u8f6c<\/b><\/strong><\/p>\n

\u8868\u9762\u7535\u8377\u5728\u8c03\u63a7\u7eb3\u7c73\u7c92\u5b50\u7684\u4f53\u5185\u884c\u4e3a\u4e0a\u6709\u7740\u975e\u5e38\u91cd\u8981\u7684\u4f5c\u7528\u3002\u901a\u5e38\u60c5\u51b5\u4e0b\uff0c\u663e\u8d1f\u7535\u548c\u7535\u4e2d\u6027\u7684\u7eb3\u7c73\u7c92\u5b50\u53ef\u4ee5\u8868\u73b0\u51fa\u8f83\u957f\u7684\u8840\u6db2\u5faa\u73af\u548c\u66f4\u597d\u7684\u80bf\u7624\u5bcc\u96c6\uff0c\u4f46\u662f\u4e0d\u80fd\u6709\u6548\u5730\u88ab\u764c\u7ec6\u80de\u541e\u566c\u3002\u76f8\u53cd\uff0c\u5e26\u6b63\u7535\u7684\u7eb3\u7c73\u7c92\u5b50\u53ef\u4ee5\u6709\u6548\u5730\u88ab\u764c\u7ec6\u80de\u541e\u566c\uff0c\u4f46\u5f88\u5bb9\u6613\u5728\u8840\u6db2\u5faa\u73af\u4e2d\u88ab\u514d\u75ab\u7cfb\u7edf\u6e05\u9664\u3002\u56e0\u6b64\u8840\u6db2\u5faa\u73af\u548c\u7ec6\u80de\u541e\u566c\u5bf9\u7eb3\u7c73\u7c92\u5b50\u7684\u8bbe\u8ba1\u8981\u6c42\u662f\u4e0d\u4e00\u6837\u7684\u3002\u7406\u60f3\u7684\u7eb3\u7c73\u7c92\u5b50\u5728\u8840\u6db2\u5faa\u73af\u4e2d\u5e94\u8be5\u4fdd\u6301\u60f0\u6027\uff0c\u5728\u5bcc\u96c6\u5728\u80bf\u7624\u7ec6\u80de\u9644\u8fd1\u65f6\uff0c\u53c8\u53ef\u4ee5\u7acb\u523b\u88ab\u764c\u7ec6\u80de\u8bc6\u522b\u3002<\/p>\n

Figure<\/b><\/strong>\u00a01<\/b><\/strong>.PAMA-DMMA\u7eb3\u7c73\u51dd\u80f6\u7684\u8868\u5f81<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a).\u9178\u6027\u73af\u5883\u8bf1\u5bfcPAMA-DMMA\u7eb3\u7c73\u51dd\u80f6\u7684\u7535\u8377\u53d8\u5316<\/p>\n

(b,c).\u5316\u5b66\u7ed3\u6784\u548c\u9178\u6027\u89e6\u53d1\u673a\u7406<\/p>\n

(d).PAMA-DMMA\u7eb3\u7c73\u51dd\u80f6\u5728pH6.8\u65f6\u7684Zeta\u70b9\u4f4d\u968f\u65f6\u95f4\u7684\u53d8\u5316<\/p>\n

(e).FITC\u6807\u8bb0\u7684PAMA-DMMA\u5728pH7.4\u548cpH6.8\u7684\u80de\u541e\u6548\u679c\u5bf9\u6bd4<\/p>\n

(f). FITC\u6807\u8bb0\u7684PAMA-DMMA\u5728\u80bf\u7624\u7ec4\u7ec7\u4e2d\u7684\u5206\u5e03<\/p>\n

Figure<\/b><\/strong>\u00a0<\/b><\/strong>2<\/b><\/strong>.\u8d1f\u8f7d\u963f\u9709\u7d20\u7684<\/b><\/strong>\u4e24\u6027\u79bb\u5b50\u7eb3\u7c73\u7c92\u5b50\u7684\u8868\u5f81<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a).\u8d1f\u8f7d\u963f\u9709\u7d20\u7684\u4e24\u6027\u79bb\u5b50\u7eb3\u7c73\u7c92\u5b50\u5728\u80bf\u7624\u9178\u6027\u73af\u5883\u4e2d\u7684\u8868\u9762\u7535\u8377\u53d8\u5316\u793a\u610f\u56fe<\/p>\n

(b).\u8840\u6d46\u4e2d\u963f\u9709\u7d20\u6d53\u5ea6\u7684\u53d8\u5316<\/p>\n

(c).\u80bf\u7624\u7ec4\u7ec7\u4e2d\u963f\u9709\u7d20\u6d53\u5ea6\u7684\u5b9a\u91cf\u5206\u6790<\/p>\n

(d).\u52a8\u7269\u5b9e\u9a8c<\/p>\n

3<\/b><\/strong>.<\/b><\/strong>\u80bf\u7624\u9178\u5ea6\u8bf1\u5bfc\u7684\u58f3\u5206\u79bb<\/b><\/strong><\/p>\n

\u9664\u4e86\u8bf1\u5bfc\u76f4\u63a5\u7684\u7535\u8377\u53d8\u5316\uff0cTACMAA\u4e5f\u53ef\u4ee5\u89e6\u53d1\u7eb3\u7c73\u7c92\u5b50\u7684\u58f3\u5206\u79bb\u3002\u7eb3\u7c73\u7c92\u5b50\u7684PEG\u5316\u53ef\u4ee5\u4fdd\u62a4\u7eb3\u7c73\u7c92\u5b50\u4e0d\u81f3\u4e8e\u8fc5\u901f\u4ece\u4f53\u5185\u6e05\u9664\uff0c\u7136\u800cPEG\u5316\u7684\u7eb3\u7c73\u7c92\u5b50\u5374\u4e0d\u80fd\u6709\u6548\u5730\u88ab\u7ec6\u80de\u541e\u566c\u3002\u6709\u6548\u7684\u65b9\u6cd5\u5c31\u662f\u5728\u7eb3\u7c73\u7c92\u5b50\u88ab\u8fd0\u8f93\u7684\u65f6\u5019\uff0c\u7528PEG\u5c06\u7eb3\u7c73\u7c92\u5b50\u4fdd\u62a4\u8d77\u6765\uff1b\u800c\u5f53\u7eb3\u7c73\u7c92\u5b50\u5230\u8fbe\u80bf\u7624\u533a\u57df\u65f6\uff0c\u5c06PEG\u79fb\u9664\u3002<\/p>\n

Figure<\/b><\/strong>\u00a0<\/b><\/strong>3<\/b><\/strong>.PEG\u4fee\u9970\u7684\u7eb3\u7c73\u7c92\u5b50\u5728\u8f7d\u836f\u4e2d\u7684\u5e94\u7528<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a).PEG\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u4ece\u5e26\u6b63\u7535\u7684\u7eb3\u7c73\u7c92\u5b50\u4e0a\u79fb\u9664<\/p>\n

(b).Cy5-siRNA\u5728\u80bf\u7624\u7ec4\u7ec7\u4e2d\u7684\u5bcc\u96c6<\/p>\n

(c).\u52a8\u7269\u5b9e\u9a8c<\/p>\n

4<\/b><\/strong>.<\/b><\/strong>\u80bf\u7624\u9178\u5ea6\u8bf1\u5bfc\u7684\u5c3a\u5bf8\u53d8\u5316<\/b><\/strong><\/p>\n

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Figure<\/b><\/strong>\u00a0<\/b><\/strong>4<\/b><\/strong>. \u5c3a\u5bf8\u53d8\u5316\u7684\u7eb3\u7c73\u7c92\u5b50\u5728\u8f7d\u836f\u4e2d\u7684\u5e94\u7528<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a).PEG\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u4ece\u7eb3\u7c73\u7c92\u5b50\u4e0a\u79fb\u9664<\/p>\n

(b).\u8d1f\u8f7dsiRNA\u7684\u7eb3\u7c73\u7c92\u5b50\u7684\u836f\u4ee3\u52a8\u529b\u5b66<\/p>\n

(c).Cy5-siRNA\u5728\u8868\u8fbeGFP\u7684\u7ec6\u80de\u4e0a\u7684\u8367\u5149\u5f3a\u5ea6<\/p>\n

5<\/b><\/strong>.<\/b><\/strong>\u80bf\u7624\u9178\u5ea6\u8bf1\u5bfc\u7684\u914d\u4f53\u6fc0\u6d3b<\/b><\/strong><\/p>\n

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Figure<\/b><\/strong>\u00a0<\/b><\/strong>5<\/b><\/strong>.\u914d\u4f53\u6fc0\u6d3b\u7684\u7eb3\u7c73\u7c92\u5b50\u5728\u8f7d\u836f\u4e2d\u7684\u5e94\u7528<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a).PCL-CDM-PAMAM\/Pt\u7684\u7ed3\u6784\uff0c\u53ca\u5176\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u81ea\u7ec4\u88c5<\/p>\n

(b).iCluster\u7684\u514d\u75ab\u8367\u5149\u56fe\u50cf<\/p>\n

(c).\u80bf\u7624\u751f\u957f\u66f2\u7ebf<\/p>\n

(d).\u5c0f\u9f20\u5b58\u6d3b\u7387<\/p>\n

\u3010\u7ed3\u8bba\u4e0e\u5c55\u671b\u3011<\/b><\/strong><\/p>\n

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Tumor-Acidity-Cleavable Maleic Acid Amide (TACMAA): A Powerful Tool for Designing Smart Nanoparticles to Overcome Delivery Barriers in Cancer Nanomedicine<\/a><\/p>\n

\u00a0(Acc. Chem. Res., 2018, DOI: 10. 1021\/acs.accounts.8b00195)<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u5b66\u672f\u7ec4gaxy\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u6574\u7406\u7f16\u8f91\u3002 \u00a0<\/p>\n

\u6750\u6599\u725b\u7f51\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1tougao@cailiaoren.com\u3002<\/p>\n

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\u738b\u5747\u6559\u6388\u7b80\u4ecb\uff1a<\/b><\/strong><\/p>\n

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\n \u675c\u91d1\u5fd7\u7279\u8058\u7814\u7a76\u5458\u7b80\u4ecb<\/b><\/strong>\uff1a<\/p>\n

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Related<\/i><\/b><\/em><\/strong>\u00a0references on this topic<\/i><\/b><\/em><\/strong>:<\/p>\n

    \n
  1. Jin-Zhi Du, Tian-Meng Sun, Wen-Jing Song, Juan Wu, Jun Wang*,A Tumor-Acidity-Activated Charge-Conversional Nanogel as an Intelligent Vehicle for Promoted Tumoral-Cell Uptake and Drug Delivery\u00a0 Chem. Int. Ed.<\/i><\/em>\u00a0<\/i><\/em>2010<\/b><\/strong>,\u00a049, 3621\u20133626.<\/li>\n
  2. Jin-Zhi Du, Xiao-Jiao Du, Cheng-Qiong Mao, Jun Wang*, Tailor-Made Dual pH-Sensitive Polymer-Doxorubicin Nanoparticles for Efficient Anti-Cancer Drug Delivery Am. Chem. Soc<\/i><\/em>. <\/i><\/em>2011<\/b><\/strong>,\u00a0133, 17560\u201317563.\u00a0<\/li>\n
  3. Hong-Jun Li#<\/sup>, Jin-Zhi Du#<\/sup>, Xiao-Jiao Du#<\/sup>, Cong-Fei Xu, Chun-Yang Sun, Hong-Xia Wang, Zhi-Ting Cao, Xian-Zhu Yang, Yan-Hua Zhu, ShumingNie*, Jun Wang*, Stimuli-Responsive Clustered Nanoparticles for Improved Tumor Penetration and Therapeutic Efficacy\u00a0 Natl. Acad. Sci. U. S. A.<\/i><\/em>\u00a0<\/i><\/em>2016<\/b><\/strong>, 113, 4164\u20134169.<\/li>\n
  4. Hong-Jun Li#<\/sup>, Jin-Zhi Du*,#<\/sup>, Jing Liu, Xiao-Jiao Du, Song Shen, Yan-Hua Zhu, Xiaoyan Wang, Xiaodong Ye, Shuming Nie*,Jun Wang*, Smart Superstructures with Ultrahigh pH-Sensitivity for Targeting Acidic Tumor Microenvironment: Instantaneous Size Switching and Improved Tumor Penetration, ACS Nano<\/i><\/em>\u00a02016<\/b><\/strong>, 10, 6753\u20136761.<\/li>\n
  5. Song Shen#, Hong-Jun Li#, Kai-Ge Chen, Yu-Cai Wang, Xian-Zhu Yang, Zhe-Xiong Lian, Jin-Zhi Du*, Jun Wang*, Spatial Targeting of Tumor-Associated Macrophages and Tumor Cells with a pH-Sensitive Cluster Nanocarrier for Cancer Chemoimmunotherapy, Nano Lett<\/i><\/em>., 2017<\/b><\/strong>, 17, 3822\u20133829.<\/li>\n
  6. Xian-Zhu Yang, Jin-Zhi Du, Cheng-Qiong Mao. Shuang Dou, Hong-Yan Long, Jun Wang*, Sheddable Nanoparticles for Tumor-Acidity Targeting Small Interfering RNA DeliveryACS Nano<\/i><\/em>\u00a0<\/i><\/em>2012<\/b><\/strong>, 6, 771\u2013781.\u00a0<\/li>\n
  7. You-Yong Yuan, Chen-Qiong Mao, Xiao-Jiao Du,Jin-Zhi Du, Feng Wang,\u00a0Jun Wang*, Surface Charge Switchable Nanoparticles Based on Zwitterionic Polymer for Enhanced Drug Delivery to Tumor\u00a0 Mater.<\/i><\/em>\u00a0<\/i><\/em>2012<\/b><\/strong>, 24, 5476\u20135480.\u00a0<\/li>\n
  8. Chun-Yang Sun#<\/sup>, Yang Liu#<\/sup>, Jin-Zhi Du#<\/sup>, Zhi-Ting Cao, Cong-Fei Xu, Jun Wang*Facile Generation of Tumor pH-Labile Linkage-Bridged Block Copolymers for Chemotherapeutic Delivery\u00a0 Chem. Int. Ed.<\/i><\/em>\u00a0<\/i><\/em>2016<\/b><\/strong>, 128, 1010-1014.<\/li>\n
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