{"id":162328,"date":"2018-12-20T08:45:55","date_gmt":"2018-12-20T00:45:55","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=162328"},"modified":"2018-12-20T08:28:17","modified_gmt":"2018-12-20T00:28:17","slug":"%e4%bb%8a%e6%97%a5nature%ef%bc%9a%e9%80%9a%e8%bf%87%e9%93%81%e5%82%ac%e5%8c%96sp3-c-h%e5%ae%98%e8%83%bd%e5%8c%96%e6%9d%a5%e9%85%b6%e6%95%88%e5%ba%94%e7%bb%84%e8%a3%85%e7%a2%b3-%e7%a2%b3%e9%94%ae","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=162328","title":{"rendered":"\u4eca\u65e5Nature\uff1a\u901a\u8fc7\u94c1\u50ac\u5316sp3\u00a0C-H\u5b98\u80fd\u5316\u6765\u9176\u6548\u5e94\u7ec4\u88c5\u78b3-\u78b3\u952e"},"content":{"rendered":"<p><strong><b>\u3010\u5f15\u8a00\u3011<\/b><\/strong><\/p>\n<p>\u867d\u7136\u78b3-\u6c22(C-H)\u952e\u5728\u6709\u673a\u5206\u5b50\u4e2d\u542b\u91cf\u4e30\u5bcc\uff0c\u4f46\u901a\u5e38\u88ab\u8ba4\u4e3a\u662f\u65e0\u53cd\u5e94\u7684\uff0c\u65e0\u6cd5\u8fdb\u884c\u5316\u5b66\u64cd\u4f5c\u3002C-H\u529f\u80fd\u5316\u6280\u672f\u7684\u6700\u65b0\u8fdb\u5c55\u5df2\u5f00\u59cb\u6539\u53d8\u8fd9\u4e00\u903b\u8f91\uff0c\u540c\u65f6\u5f3a\u8c03\u4e86sp<sup>3<\/sup>\u78b3\u4e0a\u9009\u62e9\u6027\u70f7\u57fa\u5316\u7684\u91cd\u8981\u6027\u548c\u6311\u6218\u3002<\/p>\n<p><strong><b>\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/b><\/strong><\/p>\n<p>\u4eca\u65e5\uff0c\u5728<strong><b>\u7f8e\u56fd\u52a0\u5dde\u7406\u5de5\u5927\u5b66Frances H. Arnold\u6559\u6388<\/b><\/strong><strong><b>\uff08\u901a\u8baf\u4f5c\u8005\uff09<\/b><\/strong>\u56e2\u961f\u7684\u5e26\u9886\u4e0b\uff0c\u4e0e<strong><b>\u5965\u5730\u5229\u81ea\u7136\u8d44\u6e90\u4e0e\u751f\u547d\u79d1\u5b66\u5927\u5b66<\/b><\/strong>\u5408\u4f5c\uff0c\u5f15\u5165\u4e00\u79cd\u65b0\u7684\u9176\u4fc3\u7b56\u7565\uff0c\u7528\u4e8esp<sup>3<\/sup>\u00a0C-H\u952e\u7684\u70f7\u57fa\u5316\u3002\u8fd9\u6837\u7684\u8bbe\u8ba1\u4ece\u6700\u5e7f\u6cdb\u4f7f\u7528\u7684\u751f\u7269C-H\u529f\u80fd\u5316\u8f6c\u5316\u4e2d\u83b7\u5f97\u7075\u611f\uff1aC-H\u6c27\u5316\u3002\u6765\u81ea\u7ec6\u80de\u8272\u7d20P450\u9176\u50ac\u5316\u5242\u88ab\u5b8c\u5168\u9057\u4f20\u7f16\u7801\u5e76\u5728\u7ec6\u83cc\u4e2d\u4ea7\u751f\uff0c\u5728\u7ec6\u83cc\u4e2d\uff0c\u5b83\u4eec\u53ef\u4ee5\u901a\u8fc7\u5b9a\u5411\u8fdb\u5316\u6765\u8c03\u8282\u6d3b\u6027\u548c\u9009\u62e9\u6027\u3002\u8fd9\u4e9b\u86cb\u767d\u8d28\u901a\u8fc7\u6d3b\u5316\u8fc7\u6e21\u91d1\u5c5e\u94c1\u6765\u8fdb\u884c\u8fd9\u79cd\u5316\u5b66\u53cd\u5e94\uff0c\u4e3a\u4e3b\u5bfcC-H\u5b98\u80fd\u5316\u9886\u57df\u7684\u8d35\u91d1\u5c5e\u50ac\u5316\u5242\u63d0\u4f9b\u4e86\u4e00\u79cd\u7406\u60f3\u7684\u66ff\u4ee3\u54c1\u3002\u5b9e\u9a8c\u5ba4\u8fdb\u5316\u9176\u529f\u80fd\u5316\u591a\u79cd\u542b\u6709\u82c4\u57fa\u3001\u70ef\u4e19\u57fa\u6216\u03b1-\u6c28\u57faC-H\u952e\u7684\u5e95\u7269\uff0c\u5177\u6709\u9ad8\u8f6c\u6362\u7387\u548c\u4f18\u5f02\u7684\u9009\u62e9\u6027\u3002\u5229\u7528\u8fd9\u4e9b\u9176\u7684\u94c1-\u8840\u7ea2\u7d20\u8f85\u52a9\u56e0\u5b50\u4ecb\u5bfcsp<sup>3<\/sup>\u00a0C-H\u70f7\u57fa\u5316\uff0c\u8868\u660e\u4e0d\u540c\u7684\u8840\u7ea2\u7d20\u86cb\u767d\u53ef\u4ee5\u4f5c\u4e3a\u975e\u751f\u7269\u8f6c\u5316\u7684\u6f5c\u5728\u50ac\u5316\u5242\uff0c\u5e76\u5c06\u4fc3\u8fdb\u65b0\u578b\u9176\u7c7bC-H\u5b98\u80fd\u5316\u53cd\u5e94\u5728\u5316\u5b66\u548c\u5408\u6210\u751f\u7269\u5b66\u4e2d\u7684\u5e94\u7528\u3002\u76f8\u5173\u6210\u679c\u4ee5\u9898\u4e3a\u201c<strong><b>Enzymatic assembly of carbon\u2013carbon bonds via iron-catalysed sp<\/b><\/strong><strong><sup><b>3<\/b><\/sup><\/strong><strong><b>\u00a0C\u2013H functionalization<\/b><\/strong>\u201d\u53d1\u8868\u5728\u4e86<strong><b>Nature<\/b><\/strong>\u4e0a\u3002<\/p>\n<p><strong><b>\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/b><\/strong><\/p>\n<p><strong><b>\u56fe1<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>\u9176\u4fc3C-H\u5b98\u80fd\u5316\u4f53\u7cfb<\/b><\/strong><strong><b><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-162329\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/12\/1-24.jpg\" alt=\"\" width=\"600\" height=\"759\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/12\/1-24.jpg 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/12\/1-24-237x300.jpg 237w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/b><\/strong><\/p>\n<p><strong><b>\u56fe2 <\/b><\/strong><strong><b>Haem-\u86cb\u767d\u8d28\u50ac\u5316\u7684sp<\/b><\/strong><strong><sup><b>3<\/b><\/sup><\/strong><strong><b>\u00a0C-H\u70f7\u57fa\u5316<\/b><\/strong><strong><b><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-162330\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/12\/2-26.jpg\" alt=\"\" width=\"600\" height=\"392\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/12\/2-26.jpg 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/12\/2-26-300x196.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/b><\/strong><\/p>\n<p><strong><b>\u56fe3<\/b><\/strong><strong><b>\u00a0\u7528P411-CHF\u8fdb\u884c\u82c4\u57faC-H\u70f7\u57fa\u5316<\/b><\/strong><strong><b><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-162331\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/12\/3-28.jpg\" alt=\"\" width=\"600\" height=\"727\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/12\/3-28.jpg 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/12\/3-28-248x300.jpg 248w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/b><\/strong><\/p>\n<p><strong><b>\u56fe<\/b><\/strong><strong><b>4 P411\u9176\u5728sp<\/b><\/strong><strong><sup><b>3<\/b><\/sup><\/strong><strong><b>\u00a0C-H\u70f7\u57fa\u5316\u4e2d\u7684\u5e94\u7528<\/b><\/strong><strong><b><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-162332\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/12\/4-24.jpg\" alt=\"\" width=\"600\" height=\"801\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/12\/4-24.jpg 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2018\/12\/4-24-225x300.jpg 225w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/b><\/strong><\/p>\n<p><strong><b>\u6587\u732e\u94fe\u63a5<\/b><\/strong><strong><b>\uff1a<\/b><\/strong><a href=\"https:\/\/www.nature.com\/articles\/s41586-018-0808-5\" target=\"_blank\" rel=\"noopener\"><u>Enzymatic assembly of carbon<\/u><u>&#8211;<\/u><u>carbon bonds via iron-catalysed sp<\/u><u><sup>3<\/sup><\/u><u>\u00a0C<\/u><u>&#8211;<\/u><u>H functionalization<\/u><\/a>\uff08Nature, 2018, DOI\uff1a10.1038\/s41586-018-0808-5\uff09<\/p>\n<p>\u672c\u6587\u7531\u6750\u6599\u4eba\u7f16\u8f91\u90e8\u5b66\u672f\u7ec4<strong><b>\u6728\u6587\u97ec<\/b><\/strong>\u7ffb\u8bd1\uff0c\u6750\u6599\u725b\u6574\u7406\u7f16\u8f91\u3002<\/p>\n<p>\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1tougao@cailiaoren.com\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u5f15\u8a00\u3011 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