{"id":164213,"date":"2019-01-11T06:30:03","date_gmt":"2019-01-10T22:30:03","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=164213"},"modified":"2019-01-10T19:02:48","modified_gmt":"2019-01-10T11:02:48","slug":"%e5%88%98%e5%ae%8f%e3%80%81%e6%ad%a5%e6%96%87%e5%8d%9a%e6%9d%8e%e7%90%b3%e7%90%b3-jacs-%e8%87%aa%e7%bb%84%e8%a3%85%e9%93%9c-%e6%b0%a8%e5%9f%ba%e9%85%b8%e7%ba%b3%e7%b1%b3%e9%a2%97%e7%b2%92%e7%94%a8","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=164213","title":{"rendered":"\u5218\u5b8f\u3001\u6b65\u6587\u535a&\u674e\u7433\u7433 JACS : \u81ea\u7ec4\u88c5\u94dc-\u6c28\u57fa\u9178\u7eb3\u7c73\u9897\u7c92\u7528\u4e8e\u5fae\u73af\u5883\u903b\u8f91\u95e8\u63a7\u5236\u7684\u5316\u5b66\u52a8\u529b\u5b66\u764c\u75c7\u6cbb\u7597"},"content":{"rendered":"

\u3010\u80cc\u666f\u4ecb\u7ecd\u3011<\/strong><\/p>\n

\u6076\u6027\u80bf\u7624\u7ec4\u7ec7\u7531\u4e8e\u75c5\u7406\u6027\u539f\u56e0\uff0c\u5177\u6709\u548c\u6b63\u5e38\u7ec4\u7ec7\u4e0d\u540c\u7684\u5fae\u73af\u5883\uff0c\u4f8b\u5982\u5f31\u9178\u6027pH\u3001\u4f4e\u6c27\u548c\u9ad8\u8c37\u80f1\u7518\u80bd(GSH)\u6d53\u5ea6\u7b49\u3002\u80fd\u591f\u54cd\u5e94\u7279\u5b9a\u80bf\u7624\u5fae\u73af\u5883(TME)\u7684\u7eb3\u7c73\u5236\u5242\uff0c\u53ef\u4ee5\u4ee5\u6700\u5c0f\u7684\u4fb5\u5165\u6027\u548c\u9ad8\u7279\u5f02\u6027\u6740\u6b7b\u764c\u7ec6\u80de\uff0c\u6709\u5e7f\u6cdb\u7684\u5e94\u7528\u524d\u666f\u3002\u6700\u8fd1\u53d1\u5c55\u7684\u5229\u7528\u542b\u8fc7\u6e21\u91d1\u5c5e\u94c1\u7684\u7eb3\u7c73\u9897\u7c92\u7684\u5316\u5b66\u52a8\u529b\u5b66\u7597\u6cd5\u53ef\u80fd\u5728\u80bf\u7624\u533a\u57df\u4ea7\u751f\u9ad8\u6bd2\u6027\u6d3b\u6027\u6c27(ROS)\uff0c\u5b9e\u73b0\u9ad8\u7279\u5f02\u6027\u548c\u4f4e\u6bd2\u6027\u7684\u52a8\u529b\u5b66\u80bf\u7624\u6cbb\u7597\u3002\u4f8b\u5982\uff0c\u5229\u7528\u56db\u6c27\u5316\u4e09\u94c1\u3001\u53cd\u94c1\u78c1\u6027\u9ec4\u94c1\u77ff\u548c\u542b\u94c1\u7eb3\u7c73\u9897\u7c92\u4e0e\u80bf\u7624\u7ec4\u7ec7\u4e2d\u8fc7\u91cf\u4ea7\u751f\u7684H2<\/sub>O2<\/sub>\u53cd\u5e94\uff0c\u901a\u8fc7Fe2+<\/sup>\u50ac\u5316\u7684\u82ac\u987f\u53cd\u5e94\uff0c\u4ea7\u751f\u7f9f\u57fa\u81ea\u7531\u57fa(\u00b7OH)\u6740\u6b7b\u80bf\u7624\u7ec6\u80de\u3002\u4f46\u662f\uff0c\u5c3d\u7ba1\u8fd9\u4e9b\u542b\u94c1\u7684\u7eb3\u7c73\u5236\u5242\u53ef\u4ee5\u7279\u5f02\u6027\u54cd\u5e94TME\uff0c\u5e76\u4e14\u5177\u6709\u9ad8\u7684\u6cbb\u7597\u7279\u5f02\u6027\u548c\u4f4e\u4fb5\u88ad\u6027\uff0c\u4f46\u662fFe2+\u50ac\u5316\u7684\u82ac\u987f\u53cd\u5e94\u4ec5\u5728\u5f3a\u9178\u6761\u4ef6(pH=2-4)\u4e0b\u8fdb\u884c\uff0c\u5728\u751f\u7406\u4e2d\u6027\u6761\u4ef6\u548c\u5f31\u9178\u6027\u80bf\u7624\u73af\u5883\u4e0b\u53cd\u5e94\u6548\u7387\u76f8\u5bf9\u8f83\u4f4e\u3002\u56e0\u6b64\uff0c\u5f00\u53d1\u5728\u5f31\u9178\u6027TME\u4e2d\u5177\u6709\u9ad8\u50ac\u5316\u6d3b\u6027\u548c\u7279\u5f02\u6027\u7684\u5316\u5b66\u52a8\u529b\u5b66\u7eb3\u7c73\u5236\u5242\u662f\u975e\u5e38\u6709\u610f\u4e49\u7684\u3002<\/p>\n

\u00a0 \u00a0 \u00a0 \u00a0 \u4e0eFe2+<\/sup>\u50ac\u5316\u7684\u82ac\u987f\u53cd\u5e94\u76f8\u6bd4\uff0cCu+<\/sup>\u50ac\u5316\u7684\u7c7b\u82ac\u987f\u53cd\u5e94\u5373\u4f7f\u5728\u5728\u5f31\u9178\u6027\u548c\u4e2d\u6027\u6761\u4ef6\u4e0b\uff0cCu+<\/sup>\u50ac\u5316\u7684\u7c7b\u82ac\u987f\u53cd\u5e94\u4e5f\u53ef\u4ee5\u9ad8\u6548\u53d1\u751f\uff0c\u53ef\u8fbe\u5230Fe2+<\/sup>\u82ac\u987f\u53cd\u5e94\u901f\u7387\u7684160\u500d\u3002\u7136\u800c\uff0c\u7531\u4e8eCu2+<\/sup>\/Cu+<\/sup>(~0.16 V)\u7684\u6c27\u5316\u8fd8\u539f\u7535\u4f4d\u4f4e\uff0cCu+<\/sup>\u975e\u5e38\u5bb9\u6613\u88ab\u6c27\u5316\u6210Cu2+<\/sup>\uff0c\u5bfc\u81f4\u5728\u4f53\u5185\u7eb3\u7c73\u5236\u5242\u7684\u7c7b\u82ac\u987f\u53cd\u5e94\u96be\u4ee5\u53d1\u751f\u3002\u56e0\u6b64\uff0c\u5982\u679c\u80fd\u591f\u5229\u7528\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u7279\u5f02\u6027\u5206\u5b50\u63a7\u5236Cu+<\/sup>\u5728\u80bf\u7624\u7ec4\u7ec7\u7684\u7279\u5f02\u6027\u4ea7\u751f\uff0c\u8fdb\u800c\u901a\u8fc7\u7c7b\u82ac\u987f\u53cd\u5e94\u751f\u6210ROS\uff0c\u5b9e\u73b0\u9ad8\u7279\u5f02\u6027\u7684\u80bf\u7624\u6740\u4f24\uff0c\u5c06\u662f\u975e\u5e38\u5de7\u5999\u4e14\u6709\u610f\u4e49\u7684\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u4e2d\u79d1\u9662\u5317\u4eac\u7eb3\u7c73\u80fd\u6e90\u4e0e\u7eb3\u7c73\u7cfb\u7edf\u6240\u674e\u7433\u7433\u7814\u7a76\u5458\u3001\u534e\u4e1c\u5e08\u8303\u5927\u5b66\u7684\u6b65\u6587\u535a\u6559\u6388\u548c\u5c71\u4e1c\u5927\u5b66\u5218\u5b8f\u6559\u6388\uff08\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u7b49\u4eba\u8bbe\u8ba1\u4e86\u4e00\u79cd\u81ea\u7ec4\u88c5\u94dc-\u6c28\u57fa\u9178\u786b\u9187\u76d0\u7eb3\u7c73\u9897\u7c92\uff08Cu-Cys NPs\uff09\uff0c\u53ef\u4ee5\u6309\u7167\u201cAND\u201d\u903b\u8f91\u95e8\u4f9d\u6b21\u54cd\u5e94\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u8c37\u80f1\u7518\u80bd\u548cH2<\/sub>O2<\/sub>\uff0c\u4ea7\u751f\u7f9f\u57fa\u81ea\u7531\u57fa\u4ee5\u5b9e\u73b0\u5316\u5b66\u52a8\u529b\u5b66\u6cbb\u7597\u764c\u75c7\u3002\u9996\u5148\uff0c\u901a\u8fc7\u5185\u541e\u4f5c\u7528\u5230\u80bf\u7624\u7ec6\u80de\u5185\u7684Cu-Cys NPs\u4e0e\u5c40\u90e8GSH\u53cd\u5e94\uff0cGSH\u5c06Cu2+<\/sup>\u8fd8\u539f\u4e3aCu+<\/sup>\u5e76\u8017\u5c3dGSH\u3002\u7b2c\u4e8c\u6b65\uff0cCu+<\/sup>\u4e0e\u5c40\u90e8H2<\/sub>O2<\/sub>\u53cd\u5e94\uff0c\u901a\u8fc7\u7c7bFenton\u53cd\u5e94\u751f\u6210\u9ad8\u6bd2\u6027\u7684\u7f9f\u57fa\u81ea\u7531\u57fa(\u00b7OH)\uff0c\u8fd9\u4e00\u53cd\u5e94\u5728\u5f31\u9178\u6027TME\u4e2d\u5177\u6709\u9ad8\u53cd\u5e94\u901f\u7387\uff0c\u6709\u6548\u8bf1\u5bfc\u80bf\u7624\u7ec6\u80de\u51cb\u4ea1\u3002\u7531\u4e8e\u80bf\u7624\u4e2dGSH\u548cH2<\/sub>O2<\/sub>\u4e0e\u6b63\u5e38\u7ec6\u80de\u76f8\u6bd4\u7279\u5f02\u6027\u9ad8\u6d53\u5ea6\u5b58\u5728\uff0cGSH\u548cH2<\/sub>O2<\/sub>\u63a7\u5236\u7684\u201cAND\u201d\u903b\u8f91\u95e8\u5bf9Cu-Cys NPs\u7684\u201c\u8fd8\u539f-\u6c27\u5316\u201d\u8fdb\u884c\u7cbe\u51c6\u7684\u65f6\u7a7a\u63a7\u5236\uff0c\u5bf9\u764c\u7ec6\u80de\u8868\u73b0\u51fa\u9ad8\u7ec6\u80de\u6bd2\u6027\uff0c\u800c\u5bf9\u6b63\u5e38\u7ec6\u80de\u7684\u6bd2\u6027\u6781\u4f4e\u3002\u5c0f\u9f20\u4f53\u5185\u5b9e\u9a8c\u8bc1\u5b9e\u4e86Cu-Cys NPs\u80fd\u6709\u6548\u6291\u5236\u8010\u836f\u4e73\u817a\u764c\u751f\u957f\u800c\u4e0d\u5f15\u8d77\u660e\u663e\u7684\u5168\u8eab\u6bd2\u6027\u3002\u4f5c\u4e3a\u80bf\u7624\u5fae\u73af\u5883\u7279\u5f02\u6027\u54cd\u5e94\u7684\u65b0\u578b\u786b\u9187\u94dc\u7eb3\u7c73\u5236\u5242\uff0cCu-Cys NPs\u5728\u5316\u5b66\u52a8\u529b\u5b66\u764c\u75c7\u6cbb\u7597\u4e2d\u5177\u6709\u5de8\u5927\u6f5c\u529b\u3002\u7814\u7a76\u6210\u679c\u4ee5\u9898 \u201cSelf-Assembled Copper\u2212Amino Acid Nanoparticles for in Situ Glutathione \u201cAND\u201d H2O2 Sequentially Triggered Chemodynamic Therapy\u201d<\/strong> \u53d1\u8868\u5728\u56fd\u9645\u8457\u540d\u671f\u520aJACS<\/strong>\u4e0a\u3002<\/p>\n

\u5c71\u4e1c\u5927\u5b66\u535a\u58eb\u751f\u9a6c\u4fdd\u91d1\u548c\u4e2d\u79d1\u9662\u5317\u4eac\u7eb3\u7c73\u80fd\u6e90\u6240\u535a\u58eb\u751f\u738b\u8212\u662f\u6587\u7ae0\u7684\u5e76\u5217\u7b2c\u4e00\u4f5c\u8005\u3002<\/strong><\/p>\n

\u3010\u56fe\u6587\u89e3\u6790\u3011<\/strong><\/p>\n

\u56fe\u4e00\u3001Cu-Cys NPs\u5408\u6210\u5de5\u827a\u548c\u542b\u94dc\u7eb3\u7c73\u5236\u5242\u4ecb\u5bfc\u7684\u5316\u5b66\u52a8\u529b\u5b66\u6cbb\u7597\u7684\u793a\u610f\u56fe<\/strong><\/p>\n

\"\"<\/p>\n

 <\/p>\n

\u56fe\u4e8c\u3001Cu-Cys NPs\u7684\u7406\u5316\u8868\u5f81<\/strong>
\n \"\"\uff08a\uff09Cu-Cys NPs\u7684SEM\uff08\u5de6\uff09\u548cTEM\uff08\u53f3\uff09\u56fe\u50cf\uff1b<\/p>\n

\uff08b\uff09L-\u80f1\u6c28\u9178\u548cCu-Cys NPs\u7684HRTEM\u56fe\u50cf\uff1b<\/p>\n

\uff08c\uff09Cu-Cys NPs\u548cL-\u80f1\u6c28\u9178\u7684XRD\u56fe\u8c31\uff1b<\/p>\n

\uff08d\uff09\u534a\u80f1\u6c28\u9178\u3001Cu-Cys NPs\u548cL-\u80f1\u6c28\u9178\u7684FT-IR\u5149\u8c31\uff1b<\/p>\n

\uff08e\uff09Cu-Cys NPs\u7684Cu 2p XPS\u5149\u8c31\uff1b<\/p>\n

\uff08f\uff09EPMA\u5bf9Cu-Cys NPs\u7684S\u548cCu\u5143\u7d20\u6620\u5c04mapping\uff1b<\/p>\n

\uff08g\uff09EPMA\u5bf9Cu-Cys NPs\u4e2dS\u548cCu\u7684\u5b9a\u91cf\u5206\u6790\u3002
\n \u2003
\n \u56fe\u4e09\u3001Cu-Cys NPs\u4f53\u5916\u5316\u5b66\u6cbb\u7597\u673a\u5236<\/strong>
\n \"\"\uff08a\uff09Cu-Cys NPs\u4e0eGSH \u53cd\u5e94\u4ea7\u7269\uff08Cu-G\uff09\u7684\u6fc0\u53d1\u548c\u53d1\u5c04\u5149\u8c31\uff1b<\/p>\n

\uff08b\uff09Cu-G\u7684XPS\u80fd\u8c31\uff1b<\/p>\n

\uff08c\uff09pH = 7.4\u65f6\uff0cMB\u964d\u89e3\u663e\u793a\u7531Cu\uff08I\uff09\u548cH2<\/sub>O2<\/sub>\u4e4b\u95f4\u7684\u7c7bFenton\u53cd\u5e94\u53ef\u4ee5\u4ea7\u751f\u00b7OH\uff1b<\/p>\n

\uff08d\uff09MB\u5728\u4e0d\u540c\u65f6\u95f4\u70b9\u7684\u964d\u89e3\u8fc7\u7a0b\uff1b<\/p>\n

\uff08e\uff09\u5728\u4e0d\u540cpH\u6761\u4ef6\u4e0b\u7684MB\u964d\u89e3\u901f\u7387\uff1b<\/p>\n

\uff08f\uff09TPA\u4e0e\u4ea7\u751f\u7684\u00b7OH-\u8bf1\u5bfc\u7684\u8367\u5149\u589e\u5f3a\u7684\u53cd\u5e94\u3002
\n \u2003
\n \u56fe\u56db\u3001Cu-Cys NPs\u7684\u7ec6\u80de\u6bd2\u6027\u548c\u7ec6\u80de\u5185\u4ea7\u751fROS<\/strong>
\n \"\"\uff08a\uff09Cu-Cys NPs\u57f9\u517b24 h\u7684\u4e0d\u540c\u764c\u7ec6\u80de\u548c\u6b63\u5e38\u7ec6\u80de\u7684\u5b58\u6d3b\u7387\uff1b<\/p>\n

\uff08b\uff09Cu-Cys NPs\u57f9\u517b48 h\u7684\u4e0d\u540c\u764c\u7ec6\u80de\u548c\u6b63\u5e38\u7ec6\u80de\u7684\u5b58\u6d3b\u7387\uff1b<\/p>\n

\uff08c\uff09HeLa\u7ec6\u80de\u548cADSCs\u7684\u6d3b\/\u6b7b\u67d3\u8272\uff1b<\/p>\n

\uff08d\uff09Cu-Cys NPs\u5904\u7406\u7684MCF-7R\u7ec6\u80de\u4e2dCu\u548cS\u7684EPMA mapping\uff1b<\/p>\n

\uff08e\uff09 MCF-7R\u7ec6\u80de\u4e2d\u5185\u541e\u7684Cu-Cys NPs\u548c\u80de\u5185GSH\u7684\u53cd\u5e94\uff0c\u53cd\u5e94\u4ea7\u7269\u5177\u6709\u7ea2\u8272\u8367\u5149\uff1b<\/p>\n

\uff08f\uff09100 \u03bcg mL-1<\/sup>\u7684Cu-Cys NPs\u5904\u7406\u524d\u540eMCF-7R\u7ec6\u80de\u4e2d\u7684GSH\/GSSG\u6bd4\u7387\uff1b<\/p>\n

\uff08g\uff09Cu-Cys NPs\u5904\u7406\u4e4b\u524d\u548c\u4e4b\u540e\uff0cADSCs\u548cMCF-7R\u7ec6\u80de\u4e2d\u7684ROS\u67d3\u8272\uff1b<\/p>\n

\uff08h\uff09\u76f8\u5bf9ROS\u5e94\u6fc0\u6c34\u5e73\uff1b<\/p>\n

\uff08i\uff09100 \u03bcg mL-1<\/sup>\u7684Cu-Cys NPs\u5904\u7406\u540e\uff0c\u7ec6\u80de\u6d41\u5f0f\u5206\u6790\u663e\u793aMCF-7\u7ec6\u80de\u4e2d\u7684\u4e9aG1\u6bd4\u7387\u3002<\/p>\n

\u56fe\u4e94\u3001NOD-SCID\u514d\u75ab\u7f3a\u9677\u5c0f\u9f20\u7684MCF-7R\u539f\u4f4d\u5f02\u79cd\u79fb\u690d\u7624\u4e2d\u4f7f\u7528Cu-Cys NPs\u4e0eDOX\u8fdb\u884c\u4f53\u5185\u764c\u75c7\u5316\u7597<\/strong>
\n \"\"\uff08a\uff09\u663e\u793aCu-Cys NPs\u5904\u7406\u671f\u95f4\u5c0f\u9f20\u4e2d\u80bf\u7624\u5927\u5c0f\u7684\u7167\u7247\uff1b<\/p>\n

\uff08b\uff09\u6cbb\u7597\u671f\u95f4\u5c0f\u9f20\u7684\u4f53\u91cd\u53d8\u5316\u66f2\u7ebf\uff1b<\/p>\n

\uff08c\uff09\u6cbb\u7597\u671f\u95f4\u80bf\u7624\u5927\u5c0f\u7684\u53d8\u5316\u66f2\u7ebf\uff1b<\/p>\n

\uff08d\uff09\u6cbb\u759740 d\u540e\u6765\u81eaMCF-7R\u8377\u7624\u5c0f\u9f20\u7684\u80bf\u7624\u7684\u6570\u7801\u7167\u7247\uff1b<\/p>\n

\uff08e\uff09\u6cbb\u7597\u540eMCF-7R\u8377\u7624\u5c0f\u9f20\u5185\u80bf\u7624\u7684\u5e73\u5747\u8d28\u91cf\uff1b<\/p>\n

\uff08f\uff09MCF-7R\u8377\u7624\u5c0f\u9f20\u7684\u80bf\u7624\u5207\u7247\u7684H\uff06E\u67d3\u8272\u548cTUNEL\u67d3\u8272\uff1b<\/p>\n

\uff08g\uff09\u6cbb\u7597\u540e\u4e3b\u8981\u7ec4\u7ec7\u7684\u7ec4\u7ec7\u5b66\u5206\u6790\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

\u603b\u4e4b\uff0c\u7814\u7a76\u4eba\u5458\u901a\u8fc7\u7b80\u5355\u7684\u5316\u5b66\u914d\u4f4d\u8fc7\u7a0b\u5408\u6210\u4e86\u81ea\u7ec4\u88c5\u7684Cu-Cys NPs\uff0c\u5229\u7528\u80bf\u7624\u7ec6\u80de\u5185\u7279\u5f02\u6027\u9ad8\u6d53\u5ea6\u7684GSH\u548cH2<\/sub>O2<\/sub>\u5b9e\u73b0\u4e86\u201cAND\u201d\u903b\u8f91\u95e8\u63a7\u5236\u7684\u8fd8\u539f-\u6c27\u5316\u53cd\u5e94\u8bf1\u5bfcROS\u4ea7\u751f\uff0c\u5b9e\u73b0\u5316\u5b66\u52a8\u529b\u5b66\u7597\u6cd5\u9ad8\u7279\u5f02\u6027\u3001\u9ad8\u6548\u5730\u6740\u6b7b\u764c\u7ec6\u80de\u3002\u5c0f\u9f20\u7684\u4f53\u5185\u5b9e\u9a8c\u7ed3\u679c\u8bc1\u5b9e\uff0c\u4e0e\u540c\u7b49\u5242\u91cf\u7684\u4e34\u5e8a\u5316\u7597\u836f\u7269\u963f\u9709\u7d20\u7684\u4f4e\u80bf\u7624\u6291\u5236\u7387\u548c\u9ad8\u6bd2\u6027\u76f8\u6bd4\uff0cCu-Cys NPs\u53ef\u4ee5\u6709\u6548\u5730\u6291\u5236\u8010\u836f\u4e73\u817a\u764c\u751f\u957f\u800c\u6ca1\u6709\u660e\u663e\u7684\u5168\u8eab\u6bd2\u6027\u3002\u56e0\u6b64\uff0c\u4f5c\u4e3a\u4e00\u79cd\u65b0\u578b\u91d1\u5c5e\u6709\u673a\u786b\u9187\u76d0\u7eb3\u7c73\u5236\u5242\uff0cCu-Cys NPs\u5728\u7279\u5f02\u6027\u764c\u75c7\u5316\u5b66\u52a8\u529b\u5b66\u6cbb\u7597\u65b9\u9762\u5177\u6709\u6f5c\u529b\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5<\/strong>\uff1aSelf-Assembled Copper\u2212Amino Acid Nanoparticles for in Situ Glutathione \u201cAND\u201d H2O2 Sequentially Triggered Chemodynamic Therapy<\/a>\u00a0<\/strong>(JACS, 2019<\/strong>, DOI: 10.1021\/jacs.8b08714)
\n \u2003<\/p>\n

\u901a\u8baf\u4f5c\u8005\u53ca\u56e2\u961f\u4ecb\u7ecd<\/strong><\/p>\n

\u674e\u7433\u7433\uff0c\u4e2d\u79d1\u9662\u5317\u4eac\u7eb3\u7c73\u80fd\u6e90\u4e0e\u7cfb\u7edf\u7814\u7a76\u6240\u7814\u7a76\u5458\uff0c\u7eb3\u7c73\u80fd\u6e90\u4e0e\u751f\u7269\u4f20\u611f\u8bfe\u9898\u7ec4\u8d1f\u8d23\u4eba\u3002<\/strong>2002\u5e74\u83b7\u5b89\u5fbd\u5927\u5b66\u5b66\u58eb\u5b66\u4f4d\uff0c2005\u5e74\u83b7\u5317\u4eac\u5e08\u8303\u5927\u5b66\u7855\u58eb\u5b66\u4f4d\uff0c2008\u5e74\u83b7\u4e2d\u79d1\u9662\u7406\u5316\u6240\u535a\u58eb\u5b66\u4f4d\u3002\u66fe\u83b72014\u5e74\u4e2d\u79d1\u9662\u5362\u5609\u9521\u9752\u5e74\u4eba\u624d\u5956\uff0c2015\u5e74\u4e2d\u79d1\u9662\u9752\u5e74\u4fc3\u8fdb\u4f1a\u4f1a\u5458\u3002\u4e3b\u6301\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u3001\u5317\u4eac\u5e02\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u7b4910\u4f59\u9879\u9879\u76ee\u3002\u5728Adv. Mater.\u3001J. Am. Chem. Soc.\u3001ACS Nano\u3001Adv. Funct. Mater.\u3001Nano Energy\u7b49\u5b66\u672f\u671f\u520a\u53d1\u8868\u7b2c\u4e00\/\u901a\u8baf\u4f5c\u800539\u7bc7\uff0c\u8bba\u6587\u5171\u88ab\u5f15\u75285000\u4f59\u6b21\uff0cH-index\u4e3a32\uff0c\u83b7\u6388\u6743\u53d1\u660e\u4e13\u52297\u9879\uff0c\u53c2\u7f16\u82f1\u6587\u4e13\u84573\u7ae0\u3002<\/strong><\/p>\n

\u7f51\u9875\u94fe\u63a5\uff1ahttp:\/\/www.escience.cn\/people\/linlinnano\/<\/a><\/strong><\/p>\n

\u6b65\u6587\u535a\uff0c\u534e\u4e1c\u5e08\u8303\u5927\u5b66\u6559\u6388\uff0c\u56fd\u5bb6\u6770\u51fa\u9752\u5e74\u57fa\u91d1\u83b7\u5f97\u8005\uff0c\u79d1\u6280\u90e8\u4e2d\u9752\u5e74\u79d1\u6280\u521b\u65b0\u9886\u519b\u4eba\u624d<\/strong>\u30022002\u5e74\u4e8e\u5357\u4eac\u5de5\u4e1a\u5927\u5b66\u83b7\u535a\u58eb\u5b66\u4f4d\uff0c\u540c\u5e74\u8fdb\u5165\u4e2d\u56fd\u79d1\u5b66\u9662\u4e0a\u6d77\u7845\u9178\u76d0\u7814\u7a76\u6240\u5de5\u4f5c\u30022016\u5e74\u8d77\u4f5c\u4e3a\u7279\u8058\u6559\u6388\uff08\u4e8c\u7ea7\uff09\u52a0\u76df\u534e\u4e1c\u5e08\u8303\u5927\u5b66\u5316\u5b66\u4e0e\u5206\u5b50\u5de5\u7a0b\u5b66\u9662\uff0c\u62c5\u4efb\u4e0a\u6d77\u5e02\u7eff\u8272\u5316\u5b66\u4e0e\u5316\u5de5\u8fc7\u7a0b\u7eff\u8272\u5316\u91cd\u70b9\u5b9e\u9a8c\u5ba4\u5e38\u52a1\u526f\u4e3b\u4efb\u3001\u534e\u4e1c\u5e08\u8303\u5927\u5b66\u7b2c\u4e09\u5c4a\u79d1\u5b66\u7814\u7a76\u59d4\u5458\u4f1a\u59d4\u5458\u3001\u5316\u5b66\u9662\u5b66\u672f\u59d4\u5458\u4f1a\u526f\u4e3b\u4efb\u3002\u4ee5\u7b2c\u4e00\u3001\u901a\u8baf\u4f5c\u8005\u5728Nat. Nanotechnol.\u3001J. Am. Chem. Soc.\u3001Angew. Chem.\u3001Adv. Mater.\u7b49\u5b66\u672f\u671f\u520a\u4e0a\u53d1\u8868\u8bba\u658760\u4f59\u7bc7\uff0c\u8bba\u6587SCI\u4ed6\u5f157000\u4f59\u6b21\uff1b\u83b7\u6388\u6743\u4e2d\u56fd\u53d1\u660e\u4e13\u5229\u591a\u9879\u3002<\/strong><\/p>\n

\u7f51\u9875\u94fe\u63a5\uff1ahttps:\/\/faculty.ecnu.edu.cn\/s\/3327\/main.jspy<\/a><\/strong><\/p>\n

\u5218\u5b8f\uff0c\u5c71\u4e1c\u5927\u5b66\u6676\u4f53\u6750\u6599\u56fd\u5bb6\u91cd\u70b9\u5b9e\u9a8c\u5ba4\uff0c\u6d4e\u5357\u5927\u5b66\u524d\u6cbf\u4ea4\u53c9\u79d1\u5b66\u7814\u7a76\u9662\u535a\u58eb\u751f\u5bfc\u5e08\uff0c\u56fd\u5bb6\u6770\u51fa\u9752\u5e74\u57fa\u91d1\u83b7\u5f97\u8005\u3002<\/strong>\u4e3b\u6301\u4e86\u5341\u4e94\u3001\u5341\u4e00\u4e94\u3001\u5341\u4e8c\u4e94863\u3001\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u91cd\u5927\u9879\u76ee\u8bfe\u9898\u3001\u91cd\u70b9\u9879\u76ee\uff0c\u4f5c\u4e3a\u9996\u5e2d\u4e13\u5bb6\u4e3b\u6301\u4e86\u5341\u4e09\u4e94\u56fd\u5bb6\u91cd\u70b9\u7814\u53d1\u9879\u76ee\u548c\u81ea\u7136\u57fa\u91d1\u91cd\u5927\u9879\u76ee\u3002\u5728Adv. Mater.\u3001Nano Lett.\u3001ACS Nano\u3001J. Am. Chem. Soc.\u3001Adv. Fun. Mater.\u3001Environ. Eng. Sci.\u7b49\u5b66\u672f\u671f\u520a\u4e0a\u53d1\u8868SCI\u6587\u7ae0200\u4f59\u7bc7\uff0c\u5176\u4e2d\uff0c\u5f71\u54cd\u56e0\u5b50\u5927\u4e8e10\u7684\u8fd130\u7bc7\uff0c\u6587\u7ae0\u88ab\u5f15\u6b21\u6570\u8d85\u8fc711000\u6b21\uff0cH\u56e0\u5b50\u4e3a50\uff0c2015\u5e74\u5ea6\u8fdb\u5165\u82f1\u56fd\u7687\u5bb6\u5316\u5b66\u4f1a\u671f\u520a\u201cTop 1% \u9ad8\u88ab\u5f15\u4e2d\u56fd\u4f5c\u8005\u201d\u699c\u5355\u3002\u6388\u6743\u4e13\u522930\u4f59\u9879\uff0c\u7814\u7a76\u6210\u679c\u5df2\u7ecf\u5728\u76f8\u5173\u4ea7\u4e1a\u5f97\u5230\u5e94\u7528\u3002<\/strong><\/p>\n

\u7f51\u9875\u94fe\u63a5\uff1ahttp:\/\/www.liugroup.sdu.edu.cn\/<\/a><\/strong><\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u9ad8\u751f\u7ec4\u5c0f\u80d6\u7eb8\u7f16\u8bd1\uff0c\u6750\u6599\u4eba\u6574\u7406\u3002<\/strong><\/p>\n

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