{"id":165194,"date":"2019-01-19T06:38:39","date_gmt":"2019-01-18T22:38:39","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=165194"},"modified":"2019-04-26T18:10:45","modified_gmt":"2019-04-26T10:10:45","slug":"%e5%85%a8%e7%90%83%e7%94%9f%e7%89%a9%e6%9d%90%e6%96%99%e7%ac%ac%e4%b8%80%e9%97%a8%e6%b4%be-robert-langer-%e5%92%8c%e4%bb%96%e7%9a%84%e5%ad%a6%e7%94%9f%e4%bb%ac","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=165194","title":{"rendered":"\u5168\u7403\u751f\u7269\u6750\u6599\u7b2c\u4e00\u95e8\u6d3e \u2014\u2014 Robert Langer \u548c\u4ed6\u7684\u5b66\u751f\u4eec"},"content":{"rendered":"

\u3010\u5f15\u8bed\u3011<\/strong><\/p>\n

\u751f\u7269\u4e13\u680f\uff1a\u5b9a\u671f\u68b3\u7406\u751f\u7269\u9886\u57df\u53d1\u5e03\u8fc7\u7684\u597d\u6587\u7ae0\uff0c\u603b\u7ed3\u4e00\u4e9b\u4e13\u4e1a\u77e5\u8bc6\uff0c\u77e5\u540d\u4eba\u7269\uff0c\u4e13\u4e1a\u6280\u80fd\u4f9b\u5927\u5bb6\u53c2\u8003\u3002<\/strong><\/p>\n

\u6750\u6599\u4eba\u73b0\u5728\u8bbe\u7acb\u5404\u79cd\u6587\u7ae0\u4e13\u680f\uff0c\u6240\u6d89\u53ca\u9886\u57df\u6b63\u5728\u6162\u6162\u5b8c\u5584\uff0c\u7531\u6b64\u4e5f\u9700\u8981\u66f4\u591a\u7684\u4e13\u680f\u4f5c\u8005\uff0c\u671f\u5f85\u4f60\u4eec\u7684\u52a0\u5165\uff0c\u6709\u610f\u5411\u7684\u5c0f\u4f19\u4f34\u76f4\u63a5\u5fae\u4fe1\u8054\u7cfbcailiaorenVIP\u3002\u4e0d\u8981\u518d\u72b9\u8c6b\uff0c\u4e0b\u4e00\u4e2a\u4e13\u680f\u521b\u59cb\u4eba\u5c31\u662f\u4f60\u3002\u8bf7\u8bb0\u4f4f\uff1a\u7eb5\u7136\u4f60\u79bb\u6211\u5343\u91cc\u4e07\u91cc\uff0c\u6211\u90fd\u5728\u6750\u6599\u4eba\u7b49\u4f60\uff01<\/strong><\/p>\n

\u8bf4\u5230\u751f\u7269\u6750\u6599\u9886\u57df\u7b2c\u4e00\u5927\u95e8\u6d3e\uff0c\u9886\u57df\u5185\u7684\u79d1\u7814\u5de5\u4f5c\u8005\u4eec\u4e00\u5b9a\u4f1a\u60f3\u5230\u7f8e\u56fd\u9ebb\u7701\u7406\u5de5\u5b66\u9662\u7684Robert Langer\u8bfe\u9898\u7ec4\u3002\u4f5c\u4e3a\u56fd\u9645\u7ec4\u7ec7\u5de5\u7a0b\u9886\u57df\u7684\u7b2c\u4e00\u5927\u8bfe\u9898\u7ec4\uff08\u6ca1\u6709\u4e4b\u4e00\u4e14\u4e0d\u63a5\u53d7\u53cd\u9a73\uff09\uff0c\u4f17\u591a\u751f\u7269\u6750\u6599\u9886\u57df\u7684\u5927\u4f6c\u90fd\u5728\u5176\u5b9e\u9a8c\u5ba4\u5b66\u4e60\u548c\u5de5\u4f5c\u8fc7\u3002\u8bfe\u9898\u7ec4\u62e5\u6709\u5168\u7f8e\u6700\u5927\u7684\u5b9e\u9a8c\u5ba4\u2014\u2014\u8d85\u8fc7\u767e\u4eba\u7684\u5de5\u4f5c\u4eba\u5458\uff0c\u6bcf\u5e74\u903e\u5343\u4e07\u7f8e\u91d1\u7684\u7814\u53d1\u7ecf\u8d39\uff0c\u662f\u5168\u7403\u6700\u5927\u7684\u751f\u7269\u533b\u5b66\u5de5\u7a0b\u5b9e\u9a8c\u5ba4\u3002\u548c\u5927\u591a\u6570\u79d1\u7814\u72d7\u4ee5\u704c\u6c34\u4e3a\u76ee\u7684\u7684\u642c\u7816\u5fd7\u5411\u4e0d\u540c\uff0c\u8bfe\u9898\u7ec4\u5df2\u7ecf\u5b9e\u73b0\u4e86\u4e00\u6d41\u6210\u679c\u505a\u4ea7\u54c1\uff0c\u4e8c\u6d41\u7ed3\u679c\u6c34CNS\uff0c\u4e09\u6d41\u4ea7\u7269\u6254\u9876\u520a\uff0c\u65e9\u5df2\u7ecf\u5728\u4ea7\u5b66\u7814\u4e00\u4f53\u5316\u7684\u9053\u8def\u4e0a\u72c2\u5954\u591a\u5e74\u3002\u4e0b\u9762\u5c31\u8ba9\u5c0f\u7f16\u5e26\u9886\u5927\u5bb6\u4e00\u8d77\u4ef0\u671b\u4e00\u4e0b\u8fd9\u4f4d\u725b\u903c\u7684\u8001\u677f\u548c\u4ed6\u725b\u903c\u7684\u5b66\u751f\u4eec\u3002<\/p>\n

Robert Langer\u662f\u5168\u7403\u7ec4\u7ec7\u5de5\u7a0b\u9886\u57df\u7684\u7b2c\u4e00\u4eba\uff0c\u4e5f\u662f\u7f8e\u56fd\u6700\u6709\u94b1\u7684\u79d1\u5b66\u5bb6\u4e4b\u4e00\uff0c\u4e3b\u8981\u7814\u7a76\u9776\u5411\u836f\u7269\u4f20\u9012\u7cfb\u7edf\u548c\u7ec4\u7ec7\u5de5\u7a0b\u5b66\uff0c\u76ee\u524d\u5df2\u53d1\u88681200\u591a\u7bc7\u7814\u7a76\u8bba\u6587\uff0c\u7533\u8bf7\u8fc7900\u591a\u9879\u4e13\u5229\uff0c400\u591a\u9879\u4e13\u5229\u5df2\u7ecf\u6388\u6743\u3002Robert Langer\u6bd5\u4e1a\u4e8e\u5eb7\u5948\u5c14\u5927\u5b66\u548cMIT\u5316\u5de5\u4e13\u4e1a\uff0c\u6b64\u540e\u5229\u7528\u81ea\u5df1\u7684\u5316\u5b66\u548c\u5316\u5de5\u80cc\u666f\uff0c\u7814\u7a76\u4e0e\u751f\u7269\u548c\u533b\u5b66\u76f8\u5173\u8054\u7684\u9879\u76ee\u300243\u5c81\u7684Robert Langer\u4f5c\u4e3a\u6700\u5e74\u8f7b\u7684\u5b66\u8005\u83b7\u5f97\u4e86\u7f8e\u56fd\u4e09\u5927\u79d1\u5b66\u9662\u9662\u58eb\uff08\u7f8e\u56fd\u79d1\u5b66\u9662\u3001\u7f8e\u56fd\u5de5\u7a0b\u9662\u548c\u533b\u5b66\u9662\uff09\u5934\u8854\uff0c\u83b7\u5f97\u4e86\u5305\u62ecAlbany\u533b\u5b66\u4e2d\u5fc3\u533b\u5b66\u4e0e\u751f\u7269\u533b\u5b66\u7814\u7a76\u5927\u5956\u3001Lemelson-MIT\u5956\u548cCharles Stark Draper\u5956\u5728\u5185\u7684\u591a\u79cd\u8363\u8a89\uff0c\u4e00\u76f4\u6d3b\u8dc3\u5728\u751f\u7269\u6750\u6599\u7814\u7a76\u9886\u57df\u7684\u6700\u524d\u6cbf\u3002<\/p>\n

\u9664\u4e86\u6301\u7eed\u5728\u9876\u520a\u4e0a\u53d1\u8868\u6587\u7ae0\uff0cRobert Langer\u5e26\u7740\u4ed6\u7684\u5b66\u751f\u4eec\u4e00\u5757\u513f\u521b\u529e\u4e8625\u5bb6\u516c\u53f8\uff0c\u4e3b\u8981\u6d89\u53ca\u751f\u7269\u6280\u672f\u548c\u533b\u7597\u5668\u68b0\u3002\u8fd9\u91cc\uff0c\u5c0f\u7f16\u4ecb\u7ecd\u4e00\u4e9bRobert Langer\u7684\u4ee3\u8868\u4f5c\u548c\u516c\u53f8\u3002<\/p>\n

2017\u5e74Robert Langer\u5728Nature Materials\u4e0a\u62a5\u9053\u4e86\u4e00\u79cd\u6709\u673a\u7845\u805a\u5408\u7269\uff0c\u88ab\u79f0\u4e3aXPL\uff08crosslinked polymer layer\uff09\u3002\u8fd9\u79cd\u6750\u6599\u6d82\u8986\u5728\u4eba\u4f53\u76ae\u80a4\u4e0a\u4f1a\u5f62\u6210\u4e00\u79cd\u6781\u8584\u4e14\u900f\u660e\u3001\u51e0\u4e4e\u4e0d\u53ef\u89c1\u7684\u8584\u819c\uff0c\u4e0e\u4eba\u4f53\u672c\u6765\u7684\u76ae\u80a4\u65e0\u5f02\u3002\u5728\u4eba\u4f53\u5b9e\u9a8c\u4e2d\u53d1\u73b0\uff0c\u8fd9\u79cd\u6750\u6599\u53ef\u4ee5\u6d88\u9664\u773c\u888b\uff0c\u5177\u6709\u5f88\u5f3a\u7684\u4fdd\u6e7f\u80fd\u529b\uff0c\u53ef\u4ee5\u9632\u5fa1\u7d2b\u5916\u7ebf\uff0c\u5e76\u4e0d\u6015\u6c34\u6d17\u3002\u8fd9\u79cd\u6750\u6599\u5b9b\u5982\u4eba\u7c7b\u7684\u201c\u7b2c\u4e8c\u5c42\u76ae\u80a4\u201d\uff0c\u80fd\u591f\u5f88\u597d\u5730\u4fdd\u62a4\u76ae\u80a4\uff0c\u4f7f\u808c\u80a4\u6062\u590d\u9752\u6625\u3002<\/p>\n

\"\"<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1ahttps:\/\/www.nature.com\/articles\/nmat4635<\/p>\n

2016\u5e74\u8bfe\u9898\u7ec4\u5728PNAS\u4e0a\u62a5\u9053\u4e86\u4e00\u79cd\u53ef\u4ee5\u5b9e\u73b0\u91cf\u4ea7\u3001\u4f4e\u6210\u672c\u4e14\u5b89\u5168\u7684\u6c34\u51dd\u80f6\u3002\u8fd9\u79cd\u6c34\u51dd\u80f6\u662f\u7531\u7ea4\u7ef4\u7d20\u805a\u5408\u7269\u548c\u6c34\u51dd\u80f6\u4e8c\u6c27\u5316\u7845\u7c92\u5b50\u6df7\u5408\u751f\u6210\uff0c\u7ec4\u4efd\u4e4b\u95f4\u4f9d\u9760\u805a\u5408\u7269-\u7eb3\u7c73\u7c92\u5b50\u7684\u975e\u5171\u4ef7\u952e\u4f5c\u7528\u7a33\u5b9a\u3002\u53ef\u5b9e\u73b0\u5927\u89c4\u6a21\u5236\u5907\uff0c\u4ece\u5b9e\u9a8c\u7ea7\u522b\u76840.5\u6beb\u5347\u523015\u5347\uff0c\u751a\u81f3\u66f4\u5927\uff1b\u8fd9\u79cd\u6c34\u51dd\u80f6\u53ef\u6210\u529f\u5e94\u7528\u4e8e\u7ba1\u9053\u6e05\u6d01\u548c\u706b\u707e\u6251\u706d\u3002<\/p>\n

\"\"<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1ahttps:\/\/www.pnas.org\/content\/pnas\/113\/50\/14255.full.pdf<\/p>\n

Living Proof\u662f\u6210\u7acb\u4e8e2005\u5e74\u7684\u7f8e\u5bb9\u4ea7\u54c1\u516c\u53f8\uff0c\u8001\u53cb\u8bb0\u4e2d\u7684\u597d\u83b1\u575e\u5973\u661fJennifer Aniston\u662f\u8fd9\u5bb6\u516c\u53f8\u7684\u4ee3\u8a00\u4eba\u53ca\u6295\u8d44\u4eba\u4e4b\u4e00\u3002Living Proof\u7684\u6d17\u53d1\u6c34\u4e2d\u7528\u5230\u7684\u4e00\u79cd\u53eb\u505aPolyalkylaminoester-1\u7684\u805a\u6c28\u57fa\u916f\uff0c\u5c31\u662fRobert Langer\u56e2\u961f\u5728\u7814\u7a76\u57fa\u56e0\u7597\u6cd5\u7684\u8fc7\u7a0b\u4e2d\u53d1\u73b0\u7684\uff1b\u56e2\u961f\u5f00\u53d1\u7684\u6700\u65b0\u4ea7\u54c1\u5c31\u662f\u4e00\u79cd\u53eb\u505aNeotensil\u7684\u660e\u80f6\uff0c\u5b83\u53ef\u4ee5\u8d77\u5230\u7d27\u81f4\u76ae\u80a4\u7684\u6548\u679c\u3002\u8fd9\u79cd\u4ea7\u54c1\u662f\u4e00\u79cd\u53ef\u4ee5\u8d34\u5728\u8138\u90e8\u7684\u805a\u5408\u7269\u819c\uff0c\u5b83\u53ef\u4ee5\u6a21\u62df\u5e74\u8f7b\u76ae\u80a4\u7684\u7d27\u81f4\u548c\u5f39\u6027\uff0c\u53ea\u8981\u628a\u5b83\u8d34\u5728\u8138\u4e0a\uff0c\u5c31\u53ef\u4ee5\u91cd\u65b0\u5851\u9020\u76ae\u80a4\u5f62\u8c61\uff1b\u6b64\u5916\uff0c\u516c\u53f8\u8fd8\u63a8\u51fa\u4e86\u4e00\u6b3e\u53bb\u773c\u888b\u7684\u795e\u5668\uff0c\u7531\u4e24\u652f\u7279\u5236\u51dd\u80f6\u548c\u4e00\u652f\u6309\u6469\u5668\u7ec4\u6210\u3002\u51dd\u80f6\u80fd\u591f\u5e2e\u52a9\u906e\u76d6\u773c\u888b\uff0c\u5f62\u6210\u4e00\u5c42\u65e0\u5f62\u7684\u5f39\u6027\u819c\uff0c\u4f7f\u7528\u8005\u65e0\u9700\u53bb\u533b\u9662\u66f4\u65e0\u9700\u52a8\u5200\u3002<\/p>\n

\"\"<\/p>\n

Moderna\u516c\u53f8\u81ea\u6210\u7acb\u4ee5\u6765\u5c31\u4ee5\u5f00\u53d1\u4eba\u7c7b\u86cb\u767d\u8d28\u4ee5\u53ca\u6297\u4f53\u836f\u7269\u4f5c\u4e3a\u516c\u53f8\u7684\u6838\u5fc3\u3002\u8be5\u516c\u53f8\u6280\u672f\u7684\u80cc\u540e\u7406\u5ff5\u662f\uff0c\u4fe1\u4f7f\u6838\u7cd6\u6838\u9178(RNA)\u672c\u8eab\u53ef\u4ee5\u4f5c\u4e3a\u836f\u7269\u4f7f\u7528\u2014\u2014RNA\u662f\u4ece\u8131\u6c27\u6838\u7cd6\u6838\u9178(DNA)\u8f6c\u5f55\u5408\u6210\u7684\u5e26\u6709\u9057\u4f20\u4fe1\u606f\u7684\u4e00\u7c7b\u5355\u94fe\u6838\u7cd6\u6838\u9178\u3002\u8be5\u516c\u53f8\u5728\u878d\u8d44\u4e2d\u52df\u96c64.5\u4ebf\u7f8e\u5143\uff0c\u662f\u751f\u7269\u79d1\u6280\u9886\u57df\u53f2\u4e0a\u6700\u5927\u89c4\u6a21\u7684\u79c1\u52df\u80a1\u6743\u878d\u8d44\u6d3b\u52a8\u3002\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u8be5\u516c\u53f8\u7684\u878d\u8d44\u603b\u989d\u9ad8\u8fbe\u60ca\u4eba\u76849.5\u4ebf\u7f8e\u5143\u3002<\/p>\n

\"\"<\/p>\n

\u4ecb\u7ecd\u5b8c\u5982\u6b64\u5389\u5bb3\u7684\u5927\u4f6c\uff0c\u6211\u4eec\u4e00\u8d77\u6765\u770b\u770b\u540d\u5e08\u9ebe\u4e0b\u7684\u9ad8\u5f92\u4eec<\/p>\n

1.David J. Mooney\uff0c\u54c8\u4f5b\u5927\u5b66\u6559\u6388\uff0c\u4ed6\u662f\u901a\u8fc7\u6c34\u51dd\u80f6(hydrogel)\u7b49\u6750\u6599\u6a21\u62df\u5929\u7136\u7ec6\u80de\u5916\u57fa\u8d28\u6700\u65e9\u7684\u4e00\u6279\u79d1\u5b66\u5bb6\u4e4b\u4e00\u3002David Mooney\u7684\u7814\u7a76\u65b9\u5411\u5305\u62ec\u5404\u79cd\u836f\u7269\u8f93\u9001\u3001\u514d\u75ab\u7597\u6cd5\u548c\u518d\u751f\u533b\u5b66\u9879\u76ee\uff0c\u4ee5\u4fc3\u8fdb\u4f53\u5185\u7ec4\u7ec7\u548c\u5668\u5b98\u7684\u518d\u751f\u548c\u9776\u5411\u7834\u574f\u3002<\/p>\n

David Mooney\u56e2\u961f2018\u5e74\u5728PNAS\u4e0a\u53d1\u6587\uff0c\u901a\u8fc7\u91c7\u75283D\u7ec6\u80de\u57f9\u517b\u7cfb\u7edf\u63a2\u7d22\u7ec6\u80de\u5fae\u73af\u5883\u7684\u76f8\u4e92\u4f5c\u7528\u3002\u8be5\u7cfb\u7edf\u5141\u8bb8\u72ec\u7acb\u63a7\u5236\u57f9\u517b\u57fa\u8d28\u521a\u5ea6\uff0c\u5e94\u529b\u677e\u5f1b\u548c\u7c98\u9644\u914d\u4f53\u5bc6\u5ea6\uff0c\u4ee5\u7cfb\u7edf\u5730\u63a2\u7d22\u53d7RNA-seq\u7684\u4e0d\u540c\u751f\u7269\u7269\u7406\u53c2\u6570\u7ec4\u5408\u5f71\u54cd\u7684\u8f6c\u5f55\u7a0b\u5e8f\u3002\u5728\u5c0f\u9f20\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u548c\u4eba\u76ae\u8d28\u795e\u7ecf\u5143\u7956\u7ec6\u80de\u4e2d\uff0c\u7814\u7a76\u8005\u53d1\u73b0\u8fd9\u4e9b\u5e95\u7269\u7279\u6027\u4e4b\u95f4\u5b58\u5728\u663e\u7740\u7684\u8026\u5408\uff0c\u5e76\u4e14\u6bcf\u79cd\u7279\u6027\u5bf9\u57fa\u56e0\u8868\u8fbe\u53d8\u5316\u7684\u76f8\u5bf9\u8d21\u732e\u968f\u7ec6\u80de\u7c7b\u578b\u800c\u53d8\u5316\u3002\u901a\u8fc7\u751f\u7269\u4fe1\u606f\u5b66\u5206\u6790\uff0c\u53d1\u73b0\u5305\u5c01\u5c0f\u9f20\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7684\u6c34\u51dd\u80f6\u7684\u521a\u5ea6\u8c03\u8282\u591a\u79cd\u7ec6\u80de\u56e0\u5b50\u7684\u5206\u6ccc\uff0c\u5e76\u56e0\u6b64\u5f71\u54cdTranswell\u5171\u57f9\u517b\u6a21\u578b\u4e2d\u7684\u9020\u8840\u5e72\u7ec6\u80de\u5206\u5316\u3002\u8fd9\u4e9b\u7ed3\u679c\u53ef\u4ee5\u6df1\u5165\u4e86\u89e3\u4e0d\u540c\u7ec4\u7ec7\u4e2d\u7ec6\u80de\u5982\u4f55\u6574\u5408\u751f\u7269\u7269\u7406\u7279\u5f81\uff0c\u5e76\u4e3a\u5408\u6210\u751f\u7269\u5b66\u5bb6\u548c\u751f\u7269\u5de5\u7a0b\u5e08\u63d0\u4f9b\u7b56\u7565\uff0c\u4ee5\u8bbe\u8ba1\u5bf9\u7ec6\u80de\u751f\u7269\u7269\u7406\u73af\u5883\u7684\u54cd\u5e94\u3002<\/p>\n

\"\"<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1ahttps:\/\/www.pnas.org\/content\/pnas\/115\/36\/E8368.full.pdf<\/p>\n

2.Molly Stevens\u6559\u6388\uff0c\u5e1d\u56fd\u7406\u5de5\u5b66\u9662\u751f\u7269\u533b\u5b66\u5de5\u7a0b\u7814\u7a76\u6240\u751f\u7269\u533b\u5b66\u6750\u6599\u79d1\u5b66\u7814\u7a76\u5ba4\u7684\u4e3b\u4efb\uff0c\u79d1\u7814\u754c\u516c\u8ba4\u7684\u6a21\u8303\u4eba\u7269\uff0c2010\u5e74\u88ab\u65f6\u4ee3\u5468\u520a\u8bc4\u4ef7\u4e3a40\u5c81\u4ee5\u4e0b\u79d1\u5b66\u5bb6\u4e16\u754cTOP10\u3002Molly Stevens\u56e2\u961f\u5229\u7528\u751f\u7269\u5de5\u7a0b\u65b9\u6cd5\uff0c\u4e3b\u8981\u89e3\u51b3\u751f\u7269\u4f20\u611f\u548c\u518d\u751f\u533b\u5b66\u4e2d\u7684\u95ee\u9898\u3002\u5229\u7528\u521b\u65b0\u8bbe\u8ba1\u548c\u6700\u5148\u8fdb\u7684\u6750\u6599\u8868\u5f81\u65b9\u6cd5\u6765\u7406\u89e3\u548c\u8bbe\u8ba1\u751f\u7269\u6750\u6599\u754c\u9762\u3002<\/p>\n

Molly Stevens\u56e2\u961f2018\u5e74\u5728Science\u4e0a\u53d1\u6587\u7814\u7a76\u9aa8\u77ff\u7269\u8d28\u7684\u7ec4\u88c5\u3002\u9aa8\u7ec4\u4ef6\u5206\u5c42\u7ec4\u88c5\u4ee5\u63d0\u4f9b\u521a\u5ea6\u548c\u97e7\u6027\u3002\u7136\u800c\uff0c\u9aa8\u9abc\u7684\u4e3b\u8981\u6210\u5206\u2014\u2014\u77ff\u7269\u8d28\u548c\u80f6\u539f\u86cb\u767d\u4e4b\u95f4\u7684\u7ec4\u7ec7\u548c\u5173\u7cfb\u5c1a\u672a\u660e\u786e\u9610\u660e\u3002 \u4f7f\u7528\u4e09\u7ef4\u7535\u5b50\u65ad\u5c42\u626b\u63cf\u6210\u50cf\u548c\u9ad8\u5206\u8fa8\u7387\u4e8c\u7ef4\u7535\u5b50\u663e\u5fae\u955c\uff0c\u4f5c\u8005\u8bc1\u660e\u9aa8\u77ff\u7269\u8d28\u4ece\u7eb3\u7c73\u7ea7\u5f00\u59cb\u5206\u5c42\u7ec4\u88c5\uff1a\u9488\u72b6\u77ff\u7269\u5355\u5143\u6a2a\u5411\u5408\u5e76\u5f62\u6210\u8840\u5c0f\u677f\uff0c\u5e76\u4e14\u8fd9\u4e9b\u8fdb\u4e00\u6b65\u7ec4\u7ec7\u6210\u5927\u81f4\u7684\u5806\u53e0\u5e73\u884c\u8840\u5c0f\u677f\u3002 \u8fd9\u4e9b\u5806\u53e0\u805a\u7ed3\u6210\u805a\u96c6\u4f53\uff0c\u5176\u8d85\u8fc7\u80f6\u539f\u539f\u7ea4\u7ef4\u7684\u6a2a\u5411\u5c3a\u5bf8\u5e76\u8de8\u8d8a\u76f8\u90bb\u7684\u539f\u7ea4\u7ef4\u4f5c\u4e3a\u8fde\u7eed\u7684\u4ea4\u53c9\u539f\u7ea4\u7ef4\u77ff\u5316\u3002\u5728\u8fd9\u4e9b\u89c2\u5bdf\u7684\u57fa\u7840\u4e0a\uff0c\u4f5c\u8005\u63d0\u51fa\u4e86\u77ff\u7269\u76f8\u7684\u5c42\u6b21\u548c\u8fde\u7eed\u6027\u7684\u7ed3\u6784\u6a21\u578b\uff0c\u8fd9\u6709\u52a9\u4e8e\u9aa8\u7684\u7ed3\u6784\u5b8c\u6574\u6027\u3002<\/p>\n

\"\"<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1ahttp:\/\/science.sciencemag.org\/content\/360\/6388\/eaao2189<\/p>\n

3.Ali Khademhosseini\uff0c\u9ebb\u7701\u7406\u5de5\u5b66\u9662\u6559\u6388\uff0c\u5176\u7814\u7a76\u6210\u679c\u83b740\u591a\u9879\u56fd\u5bb6\u53ca\u56fd\u9645\u5927\u5956\u548c\u8363\u8a89\u3002\u540c\u65f6\u4ed6\u662fACS Nano\u7684\u526f\u4e3b\u7f16\uff0cH\u56e0\u5b50\u9ad8\u8fbe80\uff0c\u7814\u7a76\u9886\u57df\u6d89\u53ca\u751f\u7269\u6750\u6599\u3001\u533b\u7528\u5668\u68b0\u548c\u7ec4\u7ec7\u5de5\u7a0b\u3002<\/p>\n

\u5c3d\u7ba1\u751f\u7269\u6253\u5370\u6280\u672f\u53d6\u5f97\u4e86\u8fdb\u5c55\uff0c\u4f46\u662f\u5177\u6709\u7ec6\u80de\u5f02\u8d28\u6027\u7684\u5468\u5411\u591a\u5c42\u7ba1\u72b6\u7ec4\u7ec7\u6216\u5668\u5b98\u7684\u751f\u7269\u5236\u9020\u4ecd\u7136\u662f\u4e00\u4e2a\u6311\u6218\uff0c\u4f8b\u5982\u8840\u7ba1\uff0c\u6c14\u7ba1\uff0c\u80a0\uff0c\u7ed3\u80a0\uff0c\u8f93\u5c3f\u7ba1\u548c\u5c3f\u9053\u3002\u8bfe\u9898\u7ec4\u4e8e2018\u5e74\u5728Advanced Materials\u4e0a\u53d1\u8868\u6587\u7ae0\uff0c\u63d0\u51fa\u4e86\u4e00\u79cd\u6709\u524d\u9014\u7684\u591a\u901a\u9053\u540c\u8f74\u6324\u51fa\u7cfb\u7edf\uff08MCCES\uff09\uff0c\u7528\u4e8e\u5728\u4e00\u4e2a\u6b65\u9aa4\u4e2d\u5bf9\u5468\u5411\u591a\u5c42\u7ba1\u72b6\u7ec4\u7ec7\u8fdb\u884c\u5fae\u6d41\u4f53\u751f\u7269\u6253\u5370\uff0c\u4f7f\u7528\u6784\u6210\u660e\u80f6\u7532\u57fa\u4e19\u70ef\u9170\u57fa\uff0c\u85fb\u9178\u76d0\u548c\u516b\u81c2\u805a\uff08\u4e59\u4e8c\u9187\uff09\u4e19\u70ef\u9178\u916f\u4e0e\u4e09\u5b63\u620a\u56db\u9187\u6838\u7684\u5b9a\u5236\u751f\u7269\u7c89\u672b\u3002\u8fd9\u4e9b\u53ef\u704c\u6ce8\u7684\u5957\u7ba1\u6784\u9020\u53ef\u4ee5\u5728\u751f\u7269\u6253\u5370\u7ba1\u7684\u6574\u4e2a\u957f\u5ea6\u4e0a\u4ee5\u89c4\u5219\u7684\u95f4\u9694\u4ece\u5355\u5c42\u8fde\u7eed\u8c03\u6574\u5230\u4e09\u5c42\u3002\u4f7f\u7528\u5b9a\u5236\u7684bioink\u548cMCCES\uff0c\u4ee5\u53ca\u5177\u6709\u8db3\u591f\u7684\u751f\u7269\u529f\u80fd\u6027\uff08\u5305\u62ec\u7ec6\u80de\u6d3b\u529b\uff0c\u589e\u6b96\u548c\u5206\u5316\uff09\u7684\u76f8\u5173\u7ec6\u80de\u7c7b\u578b\u751f\u7269\u6253\u5370\u51e0\u79cd\u7ba1\u72b6\u7ec4\u7ec7\u6784\u5efa\u4f53\u3002\u5229\u7528\u4eba\u5c3f\u8def\u4e0a\u76ae\u7ec6\u80de\u548c\u4eba\u8180\u80f1\u5e73\u6ed1\u808c\u7ec6\u80de\u4ee5\u53ca\u8840\u7ba1\u7ec4\u7ec7\u6784\u5efa\u4f53\uff0c\u4ee5\u53ca\u4eba\u8110\u9759\u8109\u5185\u76ae\u7ec6\u80de\u548c\u4eba\u5e73\u6ed1\u808c\u7ec6\u80de\uff0c\u5bf9\u5957\u7ba1\u5c3f\u8def\u4e0a\u76ae\u7ec4\u7ec7\u6784\u5efa\u4f53\u8fdb\u884c\u751f\u7269\u6253\u5370\u3002\u8fd9\u4e9b\u751f\u7269\u6253\u5370\u7684\u7ba1\u72b6\u7ec4\u7ec7\u53ef\u4ee5\u7528\u6d41\u4f53\u548c\u8425\u517b\u7269\u4e3b\u52a8\u704c\u6ce8\uff0c\u4ee5\u4fc3\u8fdb\u5d4c\u5165\u7ec6\u80de\u7c7b\u578b\u7684\u751f\u957f\u548c\u589e\u6b96\u3002\u8fd9\u79cd\u53ef\u8c03\u548c\u53ef\u704c\u6ce8\u7684\u5468\u5411\u591a\u5c42\u7ec4\u7ec7\u7684\u5236\u9020\u4ee3\u8868\u4e86\u5236\u9020\u4eba\u4f53\u7ba1\u72b6\u7ec4\u7ec7\u7684\u57fa\u672c\u6b65\u9aa4\u3002<\/p>\n

\"\"<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1ahttps:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.201706913<\/p>\n

4.Antonios G. Mikos\uff0c\u73b0\u4efb\u7f8e\u56fd\u751f\u7269\u6750\u6599\u5b66\u4f1a\u4e3b\u5e2d\u3001\u7f8e\u56fd\u5de5\u7a0b\u9662\u9662\u58eb\uff0c\u7f8e\u56fd\u83b1\u65af\u5927\u5b66\u751f\u7269\u5de5\u7a0b\u4e0e\u5316\u5b66\u3001\u751f\u7269\u5206\u5b50\u5de5\u7a0bLouis Calder\u6559\u6388\uff0c\u53ca\u8be5\u6821\u751f\u7269\u533b\u5b66\u5de5\u7a0bJ.W. Cox\u5b9e\u9a8c\u5ba4\u548c\u7ec4\u7ec7\u5de5\u7a0b\u201c\u5353\u8d8a\u4e2d\u5fc3\u201d\u4e3b\u4efb\u3002\u8bfe\u9898\u7ec4\u5229\u7528\u5408\u6210\u7684\u53ef\u751f\u7269\u964d\u89e3\u805a\u5408\u7269\u4f5c\u4e3a\u7ec6\u80de\u7684\u652f\u6301\u6027\u652f\u67b6\uff0c\u5f15\u5bfc\u7ec4\u7ec7\u751f\u957f\u7684\u5bfc\u7ba1\uff0c\u9776\u5411\u7ec6\u80de\u7c98\u9644\u7684\u7279\u5f02\u6027\u5e95\u7269\uff0c\u4ee5\u53ca\u7ec6\u80de\u54cd\u5e94\u7684\u523a\u6fc0\u6750\u6599\u3002<\/p>\n

\u57fa\u4e8e\u805a\u5408\u7684\u9ad8\u5185\u76f8\u4e73\u6db2\uff08polyHIPEs\uff09\u7684\u7ec4\u7ec7\u5de5\u7a0b\u652f\u67b6\u7684\u8bbe\u8ba1\u5df2\u7ecf\u6210\u4e3a\u6709\u5e0c\u671b\u7684\u9aa8\u79fb\u690d\u7b56\u7565\u3002\u5728\u76ee\u524d\u7684\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u4e86\u6c27\u5316\u8fd8\u539f\u5f15\u53d1\u7684\u6c34\u51dd\u80f6\u8f7d\u4f53\uff0c\u5176\u5229\u7528\u53ef\u751f\u7269\u964d\u89e3\u7684\u5927\u5206\u5b50\u5355\u4f53\u805a\uff08\u4e59\u4e8c\u9187\uff09-\u4e8c\u786b\u82cf\u7cd6\u9187\u539f\u4f4d\u9012\u9001\u4eba\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08hMSC\uff09\u3002\u8c03\u8282\u6c34\u51dd\u80f6\u8f7d\u4f53\u6027\u8d28\uff0c\u5305\u62ec\u7f51\u7edc\u5f62\u6210\u65f6\u95f4\uff0c\u6eb6\u80f6-\u51dd\u80f6\u5206\u6570\u548c\u6eb6\u80c0\u6bd4\uff0c\u4ee5\u5728\u6ca1\u6709\u5916\u90e8\u523a\u6fc0\u548c5-7\u5929\u7684\u9776\u7ec6\u80de\u91ca\u653e\u671f\u7684\u60c5\u51b5\u4e0b\u5b9e\u73b0\u5feb\u901f\u56fa\u5316\u3002\u4e0e\u6807\u51c6\u60ac\u6d6e\u63a5\u79cd\u76f8\u6bd4\uff0c\u8fd9\u4e9b\u539f\u4f4d\u8f7d\u4f53\u80fd\u591f\u6539\u5584hMSC\u57283D\u6253\u5370\u7684\u805aHIPE\u79fb\u690d\u7269\u4e2d\u7684\u5206\u5e03\u3002\u53e6\u5916\uff0c\u8f7d\u4f53\u52a0\u8f7d\u7684polyHIPEs\u652f\u6301\u91ca\u653e\u540ehMSC\u7684\u6301\u7eed\u7ec6\u80de\u6d3b\u529b\u548c\u6210\u9aa8\u5206\u5316\u3002\u603b\u4e4b\uff0c\u8fd9\u4e9b\u53d1\u73b0\u8bc1\u660e\u4e86\u8fd9\u79cd\u539f\u4f4d\u56fa\u5316\u6c34\u51dd\u80f6\u8f7d\u4f53\u7684\u6f5c\u529b\uff0c\u4ee5\u589e\u5f3ahMSC\u5728\u9aa8\u79fb\u690d\u7269\u4e2d\u7684\u7ec6\u80de\u5206\u5e03\u548c\u4fdd\u7559\u3002\u867d\u7136\u6700\u521d\u4e13\u6ce8\u4e8e\u6539\u5584\u9aa8\u518d\u751f\uff0c\u4f46\u662f\u9884\u671f\u5728\u4e0d\u4f9d\u8d56\u4e8e\u53ef\u5728\u5927\u79fb\u690d\u7269\u6216\u7ec4\u7ec7\u4e2d\u51cf\u5f31\u7684\u5916\u90e8\u523a\u6fc0\u800c\u5c06\u7ec6\u80de\u5305\u5c01\u5728\u6c34\u51dd\u80f6\u8f7d\u4f53\u4e2d\u7684\u80fd\u529b\u5728\u7ec4\u7ec7\u5de5\u7a0b\u4e2d\u5177\u6709\u5e7f\u6cdb\u7684\u5e94\u7528\u3002<\/p>\n

\"\"<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1ahttps:\/\/ac.els-cdn.com\/S0142961218306641\/1-s2.0-S0142961218306641-main.pdf?_tid=5aaa769d-8aae-43b5-a412-494d21b75c17&acdnat=1547627532_2b7afa9391798df24922ee82ec8405e1<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u4e13\u680f\u4f5c\u8005tt\u4f9b\u7a3f\uff0c<\/strong>\u6750\u6599\u4eba\u7f16\u8f91\u90e8\u7f16\u8f91\u3002<\/p>\n

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