{"id":169868,"date":"2019-03-21T06:30:32","date_gmt":"2019-03-20T22:30:32","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=169868"},"modified":"2019-03-20T18:09:52","modified_gmt":"2019-03-20T10:09:52","slug":"%e5%8d%97%e5%bc%80%e5%a4%a7%e5%ad%a6%e5%88%98%e8%82%b2adv-mater-%e7%bb%bc%e8%bf%b0%e5%a4%9a%e5%88%ba%e6%bf%80%e5%93%8d%e5%ba%94%e7%8e%af%e7%b3%8a%e7%b2%be%e8%b6%85%e5%88%86%e5%ad%90%e7%bb%84","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=169868","title":{"rendered":"\u5357\u5f00\u5927\u5b66\u5218\u80b2Adv. Mater. \u7efc\u8ff0:\u591a\u523a\u6fc0\u54cd\u5e94\u73af\u7cca\u7cbe\u8d85\u5206\u5b50\u7ec4\u88c5\u4f53"},"content":{"rendered":"

\u3010\u80cc\u666f\u4ecb\u7ecd\u3011<\/strong><\/p>\n

\u73af\u7cca\u7cbe\uff08CDs\uff09\u662f\u4ece\u6dc0\u7c89\u7684\u9176\u4fc3\u964d\u89e3\u4e2d\u63d0\u53d6\u7684\u4e00\u7c7b\u73af\u72b6\u4f4e\u805a\u7cd6\uff0c\u6e90\u4e8e1891\u5e74Antoine Villiers\u5728\u78b3\u6c34\u5316\u5408\u7269\u53d1\u9175\u540e\u7684\u964d\u89e3\u7269\u4e2d\u5076\u7136\u7684\u53d1\u73b0\u3002\u73af\u7cca\u7cbe\u4f5c\u4e3a\u03b1-1,4-\u7cd6\u82f7\u952e\u8fde\u63a5\u7684\u622a\u9525\u72b6\u5927\u73af\u5be1\u7cd6\u5bb6\u65cf\u4e2d\u7684\u4e00\u5458\uff0c\u6839\u636eD\u8461\u8404\u7cd6\u5355\u5143\u7684\u6570\u91cf\uff0c\u4eba\u4eec\u5c06\u5929\u7136\u73af\u7cca\u7cbe\u5206\u7c7b\u4e3a\u03b1\uff0c\u03b2\u548c\u03b3\u73af\u7cca\u7cbe\uff0c\u8fd9\u4e9b\u73af\u7cca\u7cbe\u73b0\u5728\u5747\u53ef\u4ee5\u901a\u8fc7\u5927\u89c4\u6a21\u5de5\u4e1a\u751f\u4ea7\u83b7\u5f97\u3002\u5728\u8fc7\u53bb\u7684120\u5e74\u53d1\u5c55\u8fc7\u7a0b\u4e2d\uff0c\u73af\u7cca\u7cbe\u88ab\u5e94\u7528\u4e8e\u51e0\u4e4e\u6240\u6709\u7684\u5de5\u4e1a\u9886\u57df\u4e2d\u3002\u4e0e\u6b64\u540c\u65f6\uff0c\u5728\u5b66\u672f\u9886\u57df\uff0c\u7531\u4e8e\u5b83\u4eec\u5728\u6c34\u6eb6\u6db2\u548c\u56fa\u4f53\u72b6\u6001\u4e0b\u5bf9\u5404\u79cd\u6709\u673a\u548c\u751f\u7269\u6d3b\u6027\u5e95\u7269\u5177\u6709\u4f18\u5f02\u7684\u5206\u5b50\u7ed3\u5408\u80fd\u529b\uff0c\u56e0\u6b64\u57fa\u4e8e\u73af\u7cca\u7cbe\u7684\u5206\u5b50\u8bc6\u522b\u548c\u7ec4\u88c5\u5728\u8fc7\u53bb\u51e0\u5341\u5e74\u4e2d\u5df2\u7ecf\u6210\u4e3a\u8d85\u5206\u5b50\u5316\u5b66\u4e2d\u5173\u6ce8\u7684\u7126\u70b9\u3002\u6b64\u5916\uff0c\u73af\u7cca\u7cbe\u7684\u81ea\u7ec4\u88c5\u8fd8\u884d\u751f\u51fa\u8bb8\u591a\u5176\u4ed6\u5177\u6709\u72ec\u7279\u62d3\u6251\u7ed3\u6784\u7684\u5fae\u7eb3\u7c73\u7ed3\u6784\uff0c\u5982\u7d22\u70c3\u3001\uff08\u51c6\uff09\u8f6e\u70f7\u3001\u8d85\u5206\u5b50\u805a\u5408\u7269\u3001\u4ea4\u8054\u6c34\u51dd\u80f6\u548c\u7f51\u72b6\u7269\u3001\u529f\u80fd\u5316\u7eb3\u7c73\u9897\u7c92\u7b49\uff0c\u8fd9\u6781\u5927\u5730\u6269\u5c55\u4e86\u8d85\u5206\u5b50\u5316\u5b66\u7684\u7814\u7a76\u76ee\u6807\u3002
\n \u523a\u6fc0\u54cd\u5e94\u578b\u7eb3\u7c73\u6750\u6599\u53ef\u4ee5\u9002\u5e94\u5fae\u73af\u5883\u53d8\u5316\u5e76\u4ee5\u52a8\u6001\u65b9\u5f0f\u54cd\u5e94\uff0c\u4ece\u4ece\u800c\u63d0\u4f9b\u4e86\u4e00\u79cd\u6709\u6548\u7684\u65b9\u6cd5\u6765\u6a21\u62df\u81ea\u7136\u548c\u751f\u7406\u8fc7\u7a0b\u7684\u53cd\u5e94\u3002\u8be5\u7b56\u7565\u53ef\u4ee5\u8fdb\u4e00\u6b65\u4f7f\u6211\u4eec\u80fd\u591f\u5236\u9020\u51fa\u667a\u80fd\u533b\u5b66\u548c\u4eff\u751f\u7eb3\u7c73\u6750\u6599\u3002\u6b64\u5916\uff0c\u9009\u62e9\u5728\u751f\u7269\u7cfb\u7edf\u4e2d\u8d77\u4f5c\u7528\u7684\u7406\u60f3\u523a\u6fc0\u54cd\u5e94\u6a21\u578b\u9700\u8981\u8003\u8651\u4e00\u4e9b\u56e0\u7d20\uff0c\u5982\u751f\u7269\u76f8\u5bb9\u6027\u3001\u9884\u671f\u4f5c\u7528\u4f4d\u70b9\u548c\u751f\u7269\u5b89\u5168\u95ee\u9898\u3002\u4ece\u8fd9\u4e9b\u56e0\u7d20\u6765\u8003\u8651\u7684\u8bdd\uff0c\u751f\u7269\u76f8\u5bb9\u6027\u597d\u4e14\u964d\u89e3\u540e\u964d\u89e3\u7269\u80fd\u88ab\u4eba\u4f53\u5438\u6536\u7684\u73af\u7cca\u7cbe\u5355\u5143\u88ab\u8ba4\u4e3a\u662f\u6784\u5efa\u54cd\u5e94\u523a\u6fc0\u7684\u8d85\u5206\u5b50\u7ec4\u88c5\u4f53\u6700\u4e3a\u7406\u60f3\u7684\u7ec4\u6210\u90e8\u5206\u4e4b\u4e00\uff0c\u540c\u65f6\u7531\u4e8e\u5176\u57fa\u4e8e\u975e\u5171\u4ef7\u76f8\u4e92\u4f5c\u7528\u7684\u52a8\u529b\u5b66\u548c\u53ef\u9006\u6027\u8d28\uff0c\u73af\u7cca\u7cbe\u5355\u5143\u5728\u5ba2\u4f53\u5206\u5b50\u7684\u7ed3\u5408\u4e0a\u8868\u73b0\u51fa\u826f\u597d\u7684\u5c3a\u5bf8\/\u5f62\u72b6\u5339\u914d\u80fd\u529b\u3002\u56e0\u6b64\uff0c\u901a\u8fc7\u73af\u7cca\u7cbe\u523a\u6fc0\u54cd\u5e94\u578b\u8d85\u5206\u5b50\u7eb3\u7c73\u4f53\u7cfb\u6784\u5efa\u667a\u80fd\u751f\u7269\u529f\u80fd\u6750\u6599\u5927\u6709\u53ef\u4e3a\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u6700\u8fd1\uff0cAdv. Mater.<\/strong>\u5728\u7ebf\u520a\u767b\u4e86\u5357\u5f00\u5927\u5b66\u5f20\u701b\u6e9f\u526f\u6559\u6388<\/strong>\u3001\u535a\u58eb\u751f\u5218\u8000\u534e<\/strong>\u4ee5\u53ca\u5218\u80b2\u6559\u6388<\/strong>\u603b\u7ed3\u7684\u5173\u4e8e\u591a\u523a\u6fc0\u54cd\u5e94\u7684\u73af\u7cca\u7cbe\u8d85\u5206\u5b50\u7ec4\u88c5\u4f53\u7814\u7a76\u8fdb\u5c55\u7684\u7efc\u8ff0\u3002\u9898\u76ee\u662f\u201cCyclodextrin-Based Multistimuli-Responsive Supramolecular Assemblies and Their Biological Functions<\/strong>\u201d\u3002\u5728\u8fd9\u7bc7\u7efc\u8ff0\u4e2d\uff0c\u4f5c\u8005\u4ecb\u7ecd\u4e86\u8be5\u8bfe\u9898\u7ec4\u4ee5\u53ca\u56fd\u5185\u5916\u76f8\u5173\u57fa\u4e8e\u73af\u7cca\u7cbe\u7684\u523a\u6fc0\u54cd\u5e94\u578b\u8d85\u5206\u5b50\u7eb3\u7c73\u7ec4\u88c5\u4f53\u7684\u6700\u65b0\u8fdb\u5c55\uff0c\u8ba8\u8bba\u4e86\u57fa\u4e8e\u73af\u7cca\u7cbe\u7684\u667a\u80fd\u751f\u7269\u529f\u80fd\u6750\u6599\u5236\u5907\u7684\u524d\u666f\u4ee5\u53ca\u6240\u9762\u4e34\u7684\u6311\u6218\uff0c\u63d0\u51fa\u4e86\u4f5c\u8005\u7684\u4e00\u4e9b\u89c1\u89e3\u548c\u5efa\u8bae\uff0c\u5e76\u671f\u671b\u8fd9\u4e9b\u7eb3\u7c73\u6750\u6599\u80fd\u5728\u751f\u7269\u533b\u5b66\u9886\u57df\u66f4\u597d\u5730\u8f6c\u5316\u548c\u53d1\u5c55\u3002<\/p>\n

\u3010\u56fe\u6587\u89e3\u8bfb\u3011<\/strong><\/p>\n

1\u3001\u5f15\u8a00<\/strong><\/p>\n

\u56fe\u4e00\u3001\u51e0\u79cd\u5178\u578b\u7684\u57fa\u4e8eCD\u7684\u8d85\u5206\u5b50\u7ec4\u88c5\u4f53\u7cfb<\/strong>
\n \"\"\uff08a\uff09 \u03b1\uff0c\u03b2\u548c\u03b3\u73af\u7cca\u7cbe\u7684\u5206\u5b50\u7ed3\u6784\uff08n\u4ee3\u8868D-\u8461\u8404\u7cd6\u5355\u5143\u7684\u6570\u76ee\uff09\uff1b<\/p>\n

\uff08b\uff09 \u7d22\u70c3\uff1b<\/p>\n

\uff08c\uff09 \u529f\u80fd\u5316\u7eb3\u7c73\u7c92\u5b50\uff1b<\/p>\n

\uff08d\uff09 \u8d85\u5206\u5b50\u805a\u5408\u7269\uff1b<\/p>\n

\uff08e\uff09 \u6c34\u51dd\u80f6\uff1b<\/p>\n

\uff08f\uff09 \u8f6e\u70f7\uff1b<\/p>\n

\uff08g\uff09\u4ea4\u8054\u7f51\u7edc\u7ed3\u6784\u3002<\/p>\n

2\u3001pH\u54cd\u5e94\u578b\u8d85\u5206\u5b50\u7ec4\u88c5<\/strong><\/p>\n

\u7ec6\u80de\u95f4\u5ba4\u3001\u4f53\u6db2\u548c\u5668\u5b98\u90fd\u6709\u5176\u7279\u6709\u7684pH\u5e76\u80fd\u7ef4\u6301\u5176\u9178\u78b1\u5e73\u8861\uff0c\u8fd9\u4f7f\u5f97\u6211\u4eec\u80fd\u591f\u6784\u5efapH\u654f\u611f\u7684\u8d85\u5206\u5b50\u7ec4\u4ef6\u6765\u7cbe\u786e\u5b9a\u4f4d\u4e8e\u4f5c\u7528\u4f4d\u70b9\u3002<\/p>\n

2.1\u3001pH\u654f\u611f\u94fe\u63a5<\/strong><\/p>\n

\u987a\u5f0f\u4e4c\u5934\u57fa\u3001\u8159\u57fa\u3001\u809f\u57fa\u3001\u7f29\u919b\u57fa\u3001\u916e\u57fa\u4ee5\u53ca\u7ec4\u6c28\u9178\u548c\u54aa\u5511\u57fa\u7b49\u8bb8\u591a\u9178\u4e0d\u7a33\u5b9a\u7684\u53d6\u4ee3\u57fa\u88ab\u5e7f\u6cdb\u5e94\u7528\u4e8e\u6784\u5efapH\u654f\u611f\u7eb3\u7c73\u4f53\u7cfb\u3002<\/p>\n

\u56fe\u4e8c\u3001\u57fa\u4e8e\u73af\u7cca\u7cbe\u7684pH\u54cd\u5e94\u578b\u8d85\u5206\u5b50\u7ec4\u88c5<\/strong>
\n \"\"\uff08a\uff09 I\uff09\u901a\u8fc7\u5c06\u03b1-\u73af\u7cca\u7cbe\u63a5\u5165PEG\u5316\u7684\u591a\u78f7\u9178\u916f-\u591a\u67d4\u6bd4\u661f\u524d\u836f\u4e0a\u7684\u8d85\u5206\u5b50\u51dd\u80f6\u5316\u3002II\uff09\u8d85\u5206\u5b50\u6c34\u51dd\u80f6\u7684SEM\u56fe\u50cf\u3002III\uff09\u5728\u4e0d\u540cpH\u503c\u4e0b\u7eb3\u7c73\u7c92\u5b50\u7684\u91ca\u836f\u66f2\u7ebf\uff1b<\/p>\n

\uff08b\uff09 I\uff09\u7531\u03b2\u73af\u7cca\u7cbe\u63a5\u679d\u7684\u900f\u660e\u8d28\u9178\uff08HACD\uff09\u548c\u53ef\u6c34\u89e3\u7684\u91d1\u521a\u70f7\u5f62\u6210\u7684\u8d85\u5206\u5b50\u7eb3\u7c73\u7c92\u5b50\u3002II\uff09\u8d85\u5206\u5b50\u7eb3\u7c73\u7c92\u5b50\u7684TEM\u56fe\u50cf\u3002III\uff09\u5728\u91d1\u521a\u70f7\u5ba2\u4f53\u7684\u916f\u89e3\u4f5c\u7528\u524d\uff08\u6761\u5e261\u548c3\uff09\u548c\u540e\uff08\u6761\u5e262\u548c4\uff09\uff0c\u91d1\u521a\u70f7\u57fa\u5ba2\u4f53\uff08\u6761\u5e261\u548c2\uff09\u548c\u4e8c\u5143\u8d85\u5206\u5b50\u7eb3\u7c73\u7c92\u5b50\uff08\u6761\u5e263\u548c4\uff09\u63a7\u5236pDNA\u7684\u7ed3\u5408\u53ca\u91ca\u653e\uff1b<\/p>\n

\uff08c\uff09 I\uff09\u8d1f\u8f7dICG\u7684\u548c\u03b2-\u73af\u7cca\u7cbe\u5c01\u7aef\u7684\u4e8c\u6c27\u5316\u7845-\u91d1\u6742\u5316\u7eb3\u7c73\u68d2\uff0c\u901a\u8fc7\u9759\u7535\u76f8\u4e92\u4f5c\u7528\u975e\u5171\u4ef7\u5730\u4fee\u9970\u7ebf\u7c92\u4f53\u9776\u5411\u80bd\u548c\u7535\u8377\u53ef\u9006\u7684PEG\u5316\u58f3\u805a\u7cd6\u3002II\uff09\u591a\u7ec4\u5206\u7eb3\u7c73\u68d2\u7684TEM\u56fe\u50cf\u3002III\uff09\u7eb3\u7c73\u7ec4\u4ef6\u5728\u4e0d\u540c\u65f6\u95f4\u548cpH\u503c\u4e0b\u7684Zeta\u7535\u4f4d\u53d8\u5316\uff0c\u8868\u660e\u5176\u5728\u9178\u6027\u6761\u4ef6\u4e0bpH\u8c03\u63a7\u7684\u7535\u8377\u53cd\u8f6c\u3002IV\uff09\u5904\u740621\u5929\u540e\u7684\u80bf\u7624\u91cd\u91cf\u3002<\/p>\n

2.2\u3001\u53ef\u8d28\u5b50\u5316\u4f4d\u70b9<\/strong><\/p>\n

\u5728\u73af\u7cca\u7cbe\u9aa8\u67b6\u4e2d\u5f15\u5165\u53ef\u8d28\u5b50\u5316\u6c2e\u539f\u5b50\u662f\u5b9e\u73b0pH\u654f\u611f\u7eb3\u7c73\u7ec4\u88c5\u4f53\u7684\u53e6\u4e00\u79cd\u53ef\u884c\u7b56\u7565\u3002<\/p>\n

\u56fe\u4e09\u3001\u57fa\u4e8e\u73af\u7cca\u7cbe\u7684pH\u54cd\u5e94\u578b\u8d85\u5206\u5b50\u7ec4\u88c5<\/strong>
\n \"\"\uff08a\uff09 I\uff09\u88ab\u03b2\u73af\u7cca\u7cbe-\u4fee\u9970\u7684CuS\u7eb3\u7c73\u7c92\u5b50\u5305\u8986\u7684\u82ef\u5e76\u54aa\u5511\u63a5\u679d\u7684\u4ecb\u5b54\u4e8c\u6c27\u5316\u7845\u7eb3\u7c73\u7c92\u5b50\u3002II\uff09\u8d85\u5206\u5b50\u7eb3\u7c73\u7c92\u5b50\u7684TEM\u56fe\u50cf\u3002III\uff09\u5728\u4e0d\u540cpH\u503c\u4e0b\u591a\u7ec4\u5206\u7eb3\u7c73\u7c92\u5b50\u7684\u91ca\u836f\u66f2\u7ebf\uff1b<\/p>\n

\uff08b\uff09 I\uff09\u7531N\uff0cN-\u4e8c\u5f02\u4e19\u57fa\u4e59\u4e8c\u80fa\u6539\u6027\u7684\u03b2\u73af\u7cca\u7cbe\u548c\u805a\u4e59\u4e8c\u9187\u5316\u91d1\u521a\u70f7\u5f62\u6210\u7684\u7528\u4e8e\u9012\u9001\u7425\u73c0\u9170\u80c6\u78b1\u7684\u8d85\u5206\u5b50\u7eb3\u7c73\u7c92\u5b50\u3002II\uff09\u5728\u4e0d\u540cpH\u503c\u7f13\u51b2\u6eb6\u6db2\u4e2d\u7425\u73c0\u9170\u80c6\u78b1\u7684\u4f53\u5916\u91ca\u653e\u66f2\u7ebf\u3002III\uff09\u7528\u76d0\u6c34\uff0c\u6e38\u79bb\u7425\u73c0\u9170\u80c6\u78b1\u548c\u8f7d\u836f\u8d85\u5206\u5b50\u7eb3\u7c73\u7c92\u5b50\u5904\u7406\u540e\u80ba\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u6a21\u578b\u7684\u4f53\u5185\u751f\u7269\u6210\u50cf\uff0c\u663e\u793a\u51fa\u8d85\u5206\u5b50\u7eb3\u7c73\u7c92\u5b50\u5bf9\u4e73\u817a\u764c\u80ba\u8f6c\u79fb\u7684\u589e\u5f3a\u7684\u6cbb\u7597\u6548\u679c\u3002<\/p>\n

2.3\u3001\u901a\u8fc7pKa\u8c03\u63a7\u4f18\u5316\u57fa\u4e8e\u73af\u7cca\u7cbe\u7684\u5177\u6709\u751f\u7269\u6d3b\u6027\u7ec4\u88c5\u4f53<\/strong><\/p>\n

\u9178\u5ea6\u5e38\u6570\uff08pKa\uff09\u53ef\u4ee5\u76f4\u63a5\u53cd\u6620\u6eb6\u6db2\u7684\u8d28\u5b50\u5316\u72b6\u6001\uff0c\u5316\u5b66\u57fa\u56e2\u7684\u7279\u5b9a\u7ed3\u6784-\u6d3b\u6027\u5173\u7cfb\u5f88\u5927\u7a0b\u5ea6\u4e0a\u53d6\u51b3\u4e8e\u5176\u8d28\u5b50\u5316\u72b6\u6001\u3002<\/p>\n

\u56fe\u56db\u3001\u901a\u8fc7pKa\u8c03\u63a7\u57fa\u4e8e\u73af\u7cca\u7cbe\u7684\u5177\u6709\u751f\u7269\u6d3b\u6027\u7ec4\u88c5\u4f53<\/strong>
\n \"\"\uff08a\uff09 I\uff09\u916a\u80fa\u4fee\u9970\u7684\u03b2\u73af\u7cca\u7cbe\u7684\u5206\u5b50\u7ed3\u6784\u53ca\u5176\u4e0e\u8131\u6c27\u80c6\u9178\uff08DCA\uff09\u7684\u7ed3\u5408\u6a21\u5f0f\u3002II\uff09DCA\uff0c\u916a\u80fa\u4fee\u9970\u7684\u03b2\u73af\u7cca\u7cbe\u548c\u5305\u5408\u590d\u5408\u7269\u4e0eHT-29\u7ec6\u80de\u4e00\u8d77\u5b75\u80b248\u5c0f\u65f6\u540e\u7684\u7ec6\u80de\u6bd2\u6027\u3002\u6ce8\u5c04DCA\uff0c\u916a\u80fa\u4fee\u9970\u7684\u03b2\u73af\u7cca\u7cbe\u548c\u5305\u5408\u7269\u540e\uff0c\u9759\u8109\u6ce8\u5c04\u540eIII\uff09\u8840\u6db2\u548cIV)\u5c3f\u6db2\u4e2d\u603b\u80c6\u9178\u6d53\u5ea6\uff0c\u8868\u660e\u6709\u7ec6\u80de\u6bd2\u6027\u7684DCA\u53ef\u901a\u8fc7\u5c3f\u6db2\u6392\u6cc4\u4ece\u5c0f\u9f20\u8840\u6db2\u4e2d\u5feb\u901f\u9664\u53bb\uff1b<\/p>\n

\uff08b\uff09 I\uff09\u542bHACD\uff0c\u846b\u82a6[6]\u8132\uff08CB [6]\uff09\u548c\u91d1\u521a\u70f7\u884d\u751f\u7269\uff08ADA\uff09\u7684\u8d85\u5206\u5b50siRNA\u590d\u5408\u7269\u3002I-III\uff09\u764c\u7ec6\u80de\uff08PC-3\uff09\u548cIV-VI\uff09\u6b63\u5e38\u7ec6\u80de\uff08NIH3T3\uff09\u4e0eII\uff0cV\uff09\u542b6-\u7fa7\u57fa-\u8367\u5149\u7d20\u6c28\u57fa\u78f7\u9178\u916f\u6807\u8bb0\u7684siRNA\u57f9\u517b\u57fa\uff0cIII\uff0cVI\uff09ADA\u2282 HACD\u590d\u5408\u7269\uff0c\u6216IV\uff0cVII\uff09\uff08CB [6]\u2282ADA\uff09\u2282HACD\u7ec4\u88c5\u4f53\u5171\u5b75\u80b2\u7684\u8367\u5149\u663e\u5fae\u955c\u56fe\u50cf\uff0c\u8868\u660e\u7531IV\uff09HACD\u4fee\u9970\u548c\u846b\u82a6 [6] \u8132\u534f\u540c\u7684pKa\u79fb\u4f4d\u8bf1\u5bfc\u7684\u764c\u7ec6\u80de\u4e2dsiRNA\u7684\u9776\u5411\u548c\u5185\u5316\u589e\u5f3a\u3002<\/p>\n

3\u3001\u57fa\u4e8e\u6c27\u5316\u8fd8\u539f\u54cd\u5e94\u578b\u73af\u7cca\u7cbe\u8d85\u5206\u5b50\u7ec4\u88c5<\/strong><\/p>\n

\u5728\u7ec6\u80de\u5185\u5916\u73af\u5883\u4e2d\u5e7f\u6cdb\u5206\u5e03\u7740\u4e0d\u540c\u7684\u7535\u8377\u7535\u52bf\u548c\u6c27\u5316\u8fd8\u539f\u6001\uff0c\u7814\u7a76\u5177\u6709\u6c27\u5316\u8fd8\u539f\u654f\u611f\u57fa\u56e2\u7684\u751f\u7269\u76f8\u5bb9\u6027\u7eb3\u7c73\u7ed3\u6784\u4ee5\u4fc3\u8fdb\u5bf9\u7279\u5b9a\u90e8\u4f4d\u7684\u523a\u6fc0\u54cd\u5e94\u662f\u6709\u610f\u4e49\u7684\u3002<\/p>\n

3.1\u3001\u4e8c\u786b\u952e\u94fe\u63a5<\/strong><\/p>\n

\u56fe\u4e94\u3001\u57fa\u4e8e\u73af\u7cca\u7cbe\u7684\u542b\u4e8c\u786b\u952e\u8fde\u63a5\u7684\u6c27\u5316\u8fd8\u539f\u54cd\u5e94\u578b\u7eb3\u7c73\u7ec4\u88c5\u4f53<\/strong>
\n \"\"\uff08a\uff09 I\uff09\u7531\u82dd\u4e8c\u9170\u4e9a\u80fa\uff08PDI\uff09\u548cRGD\u80bd\u5c01\u7aef\u7684\u57fa\u4e8e\u03b2\u73af\u7cca\u7cbe\u7684\u805a\u8f6e\u70f7\u53ca\u5176\u4e8c\u6b21\u7ec4\u88c5\u8fc7\u7a0b\u5f62\u6210\u8d85\u5206\u5b50\u7eb3\u7c73\u7c92\u5b50\u3002II\uff09\u6765\u81ea\u4ea4\u8054\uff08SCNP\uff09\u548c\u975e\u4ea4\u8054\uff08NP\uff09\u7eb3\u7c73\u7c92\u5b50\u7684PTX\u5728\u4e0d\u540c\u6761\u4ef6\u4e0b\u7684\u63a7\u91ca\u66f2\u7ebf\uff0c\u663e\u793a\u51fa\u7ec4\u88c5\u4f53GSH\u54cd\u5e94\u548c\u6fc0\u5149\u89e6\u53d1\u7684\u836f\u7269\u91ca\u653e\uff1b<\/p>\n

\uff08b\uff09 I\uff09CPT\u4fee\u9970\u7684\u57fa\u4e8e\u03b2\u73af\u7cca\u7cbe\u8d85\u5206\u5b50\u7ec8\u6b62\u7684\u542b\u6709\u9776\u5411\u529f\u80fd\u548c\u663e\u5f71\u5242\u7684\u805a\u5408\u7269\u53ca\u5176\u4e8c\u6b21\u7ec4\u88c5\u8fc7\u7a0b\u5f62\u6210\u8d85\u5206\u5b50\u7eb3\u7c73\u7c92\u5b50\u3002II\uff09\u6d89\u53caGSH\u89e6\u53d1\u7684\u7ea7\u8054\u53cd\u5e94\u7684\u836f\u7269\u91ca\u653e\u673a\u5236\u3002III\uff09\u542b\u6709\u548c\u4e0d\u542b\u6709GSH\u7684\u53ef\u6253\u65ad\uff08SNP\uff09\u548c\u4e0d\u53ef\u6253\u65ad\uff08SCNP\uff09\u7eb3\u7c73\u7c92\u5b50\u7684CPT\u7684\u63a7\u91ca\u66f2\u7ebf\u3002<\/p>\n

3.2\u3001\u4e8c\u8302\u94c1\u57fa<\/strong><\/p>\n

\u56fe\u516d\u3001\u542b\u4e8c\u8302\u94c1\u57fa\u7684\u57fa\u4e8e\u73af\u7cca\u7cbe\u7684\u6c27\u5316\u8fd8\u539f\u54cd\u5e94\u578b\u7eb3\u7c73\u7ec4\u88c5\u4f53<\/strong>
\n \"\"\uff08a\uff09 I\uff09\u7ecf\u4e8c\u8302\u94c1\u4fee\u9970\u03b2\u73af\u7cca\u7cbe\u81ea\u805a\u5408\u7684pDNA\u7f29\u5408\u3002II\uff09\u4ea4\u66ff\u6dfb\u52a0GSH\u548cH2<\/sub>O2<\/sub>\u65f6\u6c34\u52a8\u529b\u5b66\u76f4\u5f84\u7684\u53ef\u9006\u53d8\u5316\uff1bIII\uff09\u52a0\u5165H2<\/sub>O2<\/sub>\u524d\u540e\uff0c\u4e0d\u540cN \/ P\u6bd4\u7684pDNA\u743c\u8102\u7cd6\u51dd\u80f6\u7535\u6cf3\u5ef6\u8fdf\uff0c\u8868\u660eH2<\/sub>O2<\/sub>\u89e6\u53d1pDNA\u7684\u91ca\u653e\uff1b<\/p>\n

\uff08b\uff09 I\uff09\u901a\u8fc7\u5305\u5408\u542b\u6709\u4e8c\u786b\u952e\u8fde\u63a5\u7684CPT\u548c\u4e8c\u8302\u94c1\u7684PEG\u5316\u03b2\u73af\u7cca\u7cbe\uff0c\u7edc\u5408\u5f62\u6210\u8d85\u5206\u5b50\u80f6\u675f\uff1bII\uff09\u8d85\u5206\u5b50\u80f6\u675f\u5728\u4e0d\u540cGSH\u6d53\u5ea6\u4e0b\u7684CPT\u91ca\u653e\u66f2\u7ebf\uff1bIII\uff09\u8d85\u5206\u5b50\u80f6\u675f\u5728\u4e0d\u540cH2O2\u6d53\u5ea6\u4e0b\u7684CPT\u91ca\u653e\u66f2\u7ebf\u3002<\/p>\n

4\u3001\u57fa\u4e8e\u73af\u7cca\u7cbe\u7684\u9176\u54cd\u5e94\u578b\u8d85\u5206\u5b50\u7ec4\u88c5<\/strong><\/p>\n

\u4e00\u65b9\u9762\uff0c\u73af\u7cca\u7cbe\u4f5c\u4e3a\u4e00\u79cd\u6dc0\u7c89\u9176\u89e3\u4ea7\u7269\u7528\u4e8e\u591a\u79cd\u5b9e\u9645\u7528\u9014\uff0c\u4e0e\u73af\u7cca\u7cbe\u7cd6\u57fa\u8f6c\u79fb\u9176\u5173\u7cfb\u5bc6\u5207\uff1b\u53e6\u4e00\u65b9\u9762\uff0c\u73af\u7cca\u7cbe\u56fa\u6709\u7684\u758f\u6c34\u6027\u7a7a\u8154\u957f\u671f\u4ee5\u6765\u4e00\u76f4\u88ab\u7528\u4f5c\u6a21\u4eff\u5929\u7136\u9176\u7684\u57fa\u8d28\u7ed3\u5408\u56ca\u7684\u7406\u60f3\u6a21\u578b\u3002<\/p>\n

\u56fe\u4e03\u3001\u57fa\u4e8e\u73af\u7cca\u7cbe\u7684\u9176\u54cd\u5e94\u578b\u8d85\u5206\u5b50\u7ec4\u88c5<\/strong>
\n \"\"\uff08a\uff09 I\uff09\u03b2\u73af\u7cca\u7cbe\u8bf1\u5bfc\u5206\u89e3\u548c\u03b1-\u6dc0\u7c89\u9176\u89e6\u53d1\u7684\u8418\u6865\u8054\u53cc\u5421\u5576\u76d0\u91cd\u7ec4\uff1bII\uff09\u5728\u03b1-\u6dc0\u7c89\u9176\u5b58\u5728\u4e0b\u8418\u57fa\u56e2\u7684\u8367\u5149\u731d\u706d\uff1bIII\uff09\u8367\u5149-\u65f6\u95f4\u66f2\u7ebf\u7684\u521d\u59cb\u659c\u7387\u4e0e\u03b1-\u6dc0\u7c89\u9176\u6d53\u5ea6\u4e4b\u95f4\u7684\u7ebf\u6027\u76f8\u5173\u6027\uff1b<\/p>\n

\uff08b\uff09 I\uff09\u8d1f\u8f7d\u6c2f\u866b\u82ef\u7532\u9170\u80fa\u548c\u03b1\u73af\u7cca\u7cbe\u5c01\u7aef\u7684\u4e2d\u7a7a\u4ecb\u5b54\u7845\u7eb3\u7c73\u7c92\u5b50\u548c\u5916\u52a0\u03b1-\u6dc0\u7c89\u9176\u7684\u5feb\u901f\u91ca\u836f\uff1bII\uff09\u03b1-\u6dc0\u7c89\u9176\u5bf9\u7d2f\u79ef\u91ca\u653e\u901f\u7387\u7684\u5f71\u54cd\uff1bIII\uff09\u88c5\u8f7d\u519c\u836f\u7684\u8d85\u5206\u5b50\u7eb3\u7c73\u7c92\u5b50\u548c\u5546\u4e1a\u914d\u65b9\u5728\u4e0d\u540c\u91c7\u6458\u65f6\u95f4\u7684\u6a21\u578b\u6606\u866b\u4e0a\u7684\u751f\u7269\u6d3b\u6027\u8c03\u67e5\u7ed3\u679c\uff0c\u8868\u660e\u5b9e\u9a8c\u7ec4\u4e2d\u6709\u7740\u66f4\u9ad8\u7684\u6740\u866b\u6548\u7387\u3002<\/p>\n

5\u3001\u5149\u54cd\u5e94\u578b\u8d85\u5206\u5b50\u7ec4\u88c5<\/strong><\/p>\n

\u7531\u4e8e\u5149\u4f5c\u523a\u6fc0\u4e3a\u4e00\u79cd\u975e\u4fb5\u88ad\u6027\u548c\u73af\u4fdd\u7684\u54cd\u5e94\u65b9\u5f0f\uff0c\u5149\u54cd\u5e94\u8d85\u5206\u5b50\u7ec4\u88c5\u4f53\u5728\u6cbb\u7597\u8bb8\u591a\u5371\u53ca\u751f\u547d\u7684\u75be\u75c5\u548c\u4e2d\u6bd2\u65b9\u9762\u6709\u7740\u826f\u597d\u7684\u524d\u666f\u3002<\/p>\n

5.1\u3001\u5076\u6c2e\u5316\u5408\u7269<\/strong><\/p>\n

\u56fe\u516b\u3001\u57fa\u4e8e\u5076\u6c2e\u5316\u5408\u7269\u7684\u73af\u7cca\u7cbe\u8d85\u5206\u5b50\u7ec4\u88c5<\/strong>
\n \"\"\uff08a\uff09\u5177\u6709\u4e0d\u540c\u7c7b\u578b\u7684\u73af\u7cca\u7cbe\u7684\u4e09\u79cd\u5178\u578b\u5076\u6c2e\u82ef\u5ba2\u4f53\u3002I\uff09\u03b1\u73af\u7cca\u7cbe\u548c\u5076\u6c2e\u7684\uff1bII\uff09\u03b2\u73af\u7cca\u7cbe\u4e0e\u7fa7\u5316AAP\uff1bIII\uff09\u548c\u03b3\u73af\u7cca\u7cbe\u4e0e\u56db\u90bb\u5f02\u4e19\u6c27\u57fa\u53d6\u4ee3\u7684\u5076\u6c2e\u82ef\uff08ipAzo\uff09\uff1b<\/p>\n

\uff08b\uff09 I\uff09\u901a\u8fc7\u03b2\u73af\u7cca\u7cbe\u4fee\u9970\u7684\u7ec6\u80de\u548c\u805a\u4e59\u4e8c\u9187\u5316\u7684\u5076\u6c2e\u82ef\u4e4b\u95f4\u7684\u53ef\u9006\u5149\u5f02\u6784\u5316\uff0c\u5149\u63a7\u7ec6\u80de-\u7ec6\u80de\u63a5\u89e6\uff1bII\uff09\u5728\u7d2b\u5916\u7167\u5c04\u524d\u540e\uff0c\u03b2-CD\u4fee\u9970\u7684\u7ec6\u80de\u6d41\u5f0f\u672f\u5206\u6790\uff0c\u663e\u793a\u6563\u70b9\u56fe\u53f3\u4e0a\u8c61\u9650\u4e2d\u7ec6\u80de\u95f4\u7684\u53ef\u9006\u805a\u96c6\uff1b<\/p>\n

\uff08c\uff09 I\uff09\u7528Pd\u5d4c\u5165\u7684\u4e8c\u6c27\u5316\u7845\u7eb3\u7c73\u7c92\u5b50\uff0c\u5076\u6c2e\u82ef\u57fa\u4f5c\u4e3a\u6746\u548c\u03b2-CD\u4f5c\u4e3a\u5c01\u7aef\u5242\u5236\u5907\u7684\u5149\u54cd\u5e94\u578b\u751f\u7269\u6b63\u4ea4\u50ac\u5316\u5242\uff1bII\uff09\u7d2b\u5916\u5149\u6d3b\u5316\u4e0b\uff0c\u5728\u7ec6\u80de\u4e2d\u7531\u8d85\u5206\u5b50\u7eb3\u7c73\u7c92\u5b50\u50ac\u5316\u7684Suzuki-Miyaura\u5076\u8054\u53cd\u5e94\uff1bIII-V\uff09\u5206\u522b\u7528\u4ea4\u53c9\u5076\u8054\u4ea7\u7269\uff08\u7eff\u8272\u901a\u9053\uff09\uff0cMitoTracker Red CMXRos\uff08\u7ea2\u8272\u901a\u9053\uff09\u548cHoechst 33258\uff08\u84dd\u8272\u901a\u9053\uff09\u5bf9HeLa\u7ec6\u80de\u8fdb\u884c\u67d3\u8272\uff1b<\/p>\n

\uff08d\uff09 I\uff09\u542b\u5076\u6c2e\u82ef\u7684\u9506\u91d1\u5c5e-\u6709\u673a\u9aa8\u67b6\u7684\u5236\u5907\u53ca\u5176\u901a\u8fc7\u03b2\u73af\u7cca\u7cbe\u4e0e\u5076\u6c2e\u82ef\u57fa\u7684\u53ef\u9006\u5730\u5149\u5f02\u6784\u7ed3\u5408\uff0c\u6765\u6355\u83b7\u548c\u91ca\u653e\u7f57\u4e39\u660eB\uff1bII\uff09\u7d2b\u5916\u5149\u7167\u5c04\u548c\u91d1\u521a\u70f7\u80fa\u4f5c\u4e3a\u7ade\u4e89\u5ba2\u4f53\u5f15\u53d1\u7684\u8367\u5149\u67d3\u6599\u7684\u9010\u6b65\u91ca\u653e\u3002<\/p>\n

\u56fe\u4e5d\u3001\u542b\u5076\u6c2e\u5316\u5408\u7269\u7684\u73af\u7cca\u7cbe\u8d85\u5206\u5b50\u7ec4\u88c5\u4f53<\/strong>
\n \"\"\uff08a\uff09 \u901a\u8fc7\u5076\u6c2e\u82ef-\u6865\u8054\u53cc\uff08\u03b2\u73af\u7cca\u7cbe\uff09\u548c\u91d1\u521a\u70f7\u4fee\u9970\u7684\u82ef\u4e19\u6c28\u9178\u4e8c\u80bd\u4e4b\u95f4\u7684\u8d85\u5206\u5b50\u7ec4\u88c5\u6210\u7eb3\u7c73\u7247-\u7eb3\u7c73\u7ba1\u7684\u76f8\u4e92\u8f6c\u5316\uff1b<\/p>\n

\uff08b\uff09 I\uff09\u03b2\u73af\u7cca\u7cbe\u4fee\u9970\u7684\u91d1\u7eb3\u7c73\u7c92\u5b50\uff1bII\uff09\u4e24\u4eb2\u6027\u03b2\u73af\u7cca\u7cbe\u7eb3\u7c73\u7c92\u5b50\u4e0e\u53cd\u5f0f\u548c\u987a\u5f0f-AAP\u7684\u53ef\u9006\u805a\u96c6\u548c\u5206\u6563\uff1b<\/p>\n

\uff08c\uff09 I\uff09\u901a\u8fc7PTX\u4fee\u9970\u7684\u03b2\u73af\u7cca\u7cbe\u548cAAP\u5149\u63a7\u805a\u96c6\u5fae\u7ba1\uff1bII\uff09A549\u7ec6\u80de\u4e2d\u4e3b-\u5ba2\u4f53\u590d\u5408\u7269\u5bf9\u805a\u96c6\u5fae\u7ba1\u7684\u5171\u5b9a\u4f4d\u30024’\uff0c6-\u4e8c\u8112\u57fa-2-\u82ef\u57fa\u5432\u54da\u4e8c\u76d0\u9178\u76d0\u6c34\u5408\u7269\uff08DAPI\uff09\uff0c\u5f02\u786b\u6c30\u9178\u8367\u5149\u7d20\uff08FITC\uff09\u548c\u542b\u91d1\u521a\u70f7\u7684\u7f57\u4e39\u660eB\uff08RhB-ADA\uff09\u5206\u522b\u7528\u4e8e\u7ec6\u80de\u6838\uff0c\u5fae\u7ba1\u548c\u03b2\u73af\u7cca\u7cbe\u67d3\u8272\u3002<\/p>\n

5.2\u3001\u4e8c\u82b3\u57fa\u4e59\u70ef<\/strong><\/p>\n

\u56fe\u5341\u3001\u57fa\u4e8e\u73af\u7cca\u7cbe\u7684\u5149\u54cd\u5e94\u578b\u8d85\u5206\u5b50\u7ec4\u88c5<\/strong>
\n \"\"\uff08a\uff09 I\uff09\u57fa\u4e8e\u5168\u6c1f\u73af\u620a\u70ef\u4e8c\u82b3\u57fa\u4e59\u70ef\u7684\u5149\u81f4\u53d8\u8272\u53cd\u5e94\uff1bII\uff09\u7531\u4e24\u4eb2\u6027\u535f\u5549\uff0c\u82b1\u83c1\u67d3\u6599\u548c\u4e8c\u82b3\u57fa\u4e59\u70ef\u6865\u8054\u53cc\uff08\u7532\u57fa\uff09\u73af\u7cca\u7cbe\u5f62\u6210\u7684\u4e09\u5143\u7403\u5f62\u7eb3\u7c73\u7c92\u5b50\uff1bIII\uff09\u4e09\u5143\u7ec4\u88c5\u4f53\u5728254 nm\u7d2b\u5916\u5149\u7167\u5c04\u4e0b\u7684\u8367\u5149\u731d\u706d\uff1bIV\uff09\u5728\u7d2b\u5916\u548c\u53ef\u89c1\u5149\u7684\u4ea4\u66ff\u7167\u5c04\u4e0b\uff0c\u4e09\u5143\u7ec4\u88c5\u4f53\u5728680 nm\u5904\u7684\u8367\u5149\u53d1\u5c04\u5149\u8c31\u548c\u5f3a\u5ea6\u53d8\u5316\uff1b<\/p>\n

\uff08b\uff09 I\uff09\u5149\u9178\u5316\u90e8\u82b1\u9752\u7684\u5149\u81f4\u53d8\u8272\u53cd\u5e94\uff1bII\uff09\u7531\u03b2\u73af\u7cca\u7cbe\u548cZn2+<\/sup>\u914d\u4f4d\u76844,4′-\u8054\u5421\u5576\u5f62\u6210\u7684\u805a\u8f6e\u70f7\u53ca\u5176\u5728\u6c34\u6eb6\u6db2\u4e2d\u7531\u5149\u9178\u5316\u90e8\u82b1\u9752\u5f15\u53d1\u7684\u53ef\u9006\u81ea\u7ec4\u88c5\uff1b<\/p>\n

\uff08c\uff09 I\uff09CPT\u548c\u8418\u4e8c\u7532\u9170\u4e9a\u80fa\uff08Nap-CPT-Ad\uff09\u4fee\u9970\u7684\u91d1\u521a\u70f7\u884d\u751f\u7269\u4e0eHACD\u7edc\u5408\u5f62\u6210\u8d1f\u8f7dNIR\u8367\u5149\u67d3\u6599\u7684\u8d85\u5206\u5b50\u7eb3\u7c73\u7c92\u5b50\uff1bII\uff09\u5728\u6fc0\u5149\u7167\u5c04\u4e0d\u540c\u65f6\u95f4\u540e\uff0c\u751f\u7406\u76d0\u6c34\uff08\u5bf9\u7167\uff09\u548c\u8d1f\u8f7d\u67d3\u6599\u7684\u7eb3\u7c73\u7c92\u5b50\uff0c\u80bf\u7624\u7167\u5c04\u533a\u7684\u6700\u5927\u6e29\u5ea6\u66f2\u7ebf\uff1bIII\uff09\u5728\u6fc0\u5149\u7167\u5c04\u4e0d\u540c\u65f6\u95f4\u540e\uff0c\u751f\u7406\u76d0\u6c34\uff08\u5bf9\u7167\uff09\u548c\u8d1f\u8f7d\u67d3\u6599\u7684\u7eb3\u7c73\u7c92\u5b50\u5904\u7406\u7684\u8377\u7624\u5c0f\u9f20\u7684\u7ea2\u5916\u70ed\u56fe\u50cf\uff1b<\/p>\n

\uff08d\uff09 I\uff09\u7531\u4e0a\u8f6c\u6362\u6750\u6599\u4e3a\u6838\u5c42\uff0c\u542b\u4e9a\u7532\u57fa\u84dd\u7684\u4e8c\u6c27\u5316\u7845\u4e3a\u5939\u5fc3\u58f3\u5c42\uff0c\u8d1f\u8f7d\u7f57\u4e39\u660eB\u7684\u03b2\u73af\u7cca\u7cbe\u5c01\u7aef\u7684\u4ecb\u5b54\u4e8c\u6c27\u5316\u7845\u58f3\u5c42\u7ec4\u6210\u7684\u6838-\u58f3-\u58f3\u7eb3\u7c73\u7c92\u5b50\uff1bII\uff09\u8d85\u5206\u5b50\u7eb3\u7c73\u7c92\u5b50\u5728980 nm\uff0c\u4e0d\u540c\u529f\u7387\u5bc6\u5ea6\u8fde\u7eedNIR\u7167\u5c04\u4e0b\u7684\u91ca\u653e\u66f2\u7ebf\u3002<\/p>\n

5.3\u3001\u5176\u4ed6\u7c7b\u578b\u7684\u57fa\u4e8e\u73af\u7cca\u7cbe\u7684\u5149\u54cd\u5e94\u578b\u7eb3\u7c73\u7ec4\u88c5\u4f53<\/strong><\/p>\n

6\u3001\u57fa\u4e8e\u73af\u7cca\u7cbe\u7684\u78c1\u54cd\u5e94\u578b\u8d85\u5206\u5b50\u7ec4\u88c5<\/strong><\/p>\n

\u56fe\u5341\u4e00\u3001\u57fa\u4e8e\u73af\u7cca\u7cbe\u7684\u78c1\u54cd\u5e94\u578b\u8d85\u5206\u5b50\u7ec4\u88c5<\/strong>
\n \"\"\uff08a\uff09 \u542b\u7ebf\u7c92\u4f53\u9776\u5411\u80bd\u4fee\u9970\u7684\u78c1\u6027\u7eb3\u7c73\u7c92\u5b50\uff08MitP-MNP\uff09\u7684HACD\u4ea4\u8054\u5f62\u6210\u7684\u4e8c\u5143\u8d85\u5206\u5b50\u7eb3\u7c73\u7ea4\u7ef4\uff1b<\/p>\n

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\uff08c\uff09 Matrigel\u4fb5\u88ad\u6a21\u578b\u4e2d\u7684\u80bf\u7624\u7ec6\u80de\u4fb5\u88ad\u793a\u610f\u56fe\uff0c\u8868\u660e\u7531MitP-MNP\u2282HACD\u7eb3\u7c73\u7ea4\u7ef4\u8bf1\u5bfc\u7684\u6291\u5236\u4f5c\u7528\u589e\u5f3a\uff1b<\/p>\n

\uff08d\uff09 MitP-MNP\u2282HACD\u7eb3\u7c73\u7ea4\u7ef4\u5bf9A549\u7ec6\u80de\u8f6c\u79fb\u7684\u4f53\u5185\u6291\u5236\u3002<\/p>\n

7\u3001\u603b\u7ed3\u4e0e\u5c55\u671b<\/strong><\/p>\n

\u5728\u8fd9\u7bc7\u7efc\u8ff0\u4e2d\uff0c\u4f5c\u8005\u603b\u7ed3\u4e86\u6700\u8fd1\u51e0\u5e74\u4e2d\u57fa\u4e8e\u73af\u7cca\u7cbe\u7684\u523a\u6fc0\u54cd\u5e94\u578b\u8d85\u5206\u5b50\u7ec4\u88c5\u7684\u7814\u7a76\u8fdb\u5c55\uff0c\u5e76\u9009\u62e9\u4e00\u4e9b\u5177\u6709\u4ee3\u8868\u6027\u7684\u4f8b\u5b50\u5e76\u4ecb\u7ecd\u4e86\u5b83\u4eec\u7684\u76f8\u5173\u751f\u7269\u5b66\u529f\u80fd\u3002\u8fd9\u4e9b\u8d85\u5206\u5b50\u6750\u6599\u7684\u6f5c\u5728\u751f\u7269\u5b66\u5e94\u7528\u5df2\u7ecf\u4ece\u751f\u7269\u4f20\u611f\u3001\u836f\u7269\u9012\u9001\u91ca\u653e\u3001\u7ec6\u80de\u5185\/\u7ec6\u80de\u95f4\u4fe1\u53f7\u4f20\u5bfc\u5230\u75be\u75c5\u7684\u8bca\u65ad\u548c\u6cbb\u7597\u7b49\u65b9\u9762\u5f97\u5230\u4e86\u5e7f\u6cdb\u7684\u5e94\u7528\u3002\u4f5c\u8005\u8ba4\u4e3a\u5c3d\u7ba1\u8be5\u9886\u57df\u76ee\u524d\u53d6\u5f97\u4e86\u663e\u8457\u7684\u8fdb\u5c55\uff0c\u4f46\u8981\u638c\u63e1\u7ed3\u6784-\u6d3b\u6027\u5173\u7cfb\u5e76\u4fc3\u8fdb\u5176\u5b9e\u9645\u5e94\u7528\u4ecd\u9700\u8981\u5927\u91cf\u7684\u52aa\u529b\uff0c\u4f5c\u8005\u8ba4\u4e3a\u4ee5\u4e0b\u51e0\u70b9\u662f\u9700\u8981\u91cd\u70b9\u5173\u6ce8\u7684\u95ee\u9898\u3002<\/p>\n

i\uff09 \u9664\u4e86\u4e3b\u8981\u7684\u5355\u548c\u591a\u53d6\u4ee3\u7684\u03b2\u73af\u7cca\u7cbe\u4e4b\u5916\uff0c\u5728\u6269\u5c55\u5176\u4ed6\u7c7b\u578b\u7684\u73af\u7cca\u7cbe\u7684\u4f7f\u7528\u65b9\u9762\u4ecd\u5b58\u5728\u5de8\u5927\u7684\u6311\u6218\uff0c\u5e76\u4e14\u7528\u4e8e\u533a\u57df\u9009\u62e9\u6027\u4fee\u9970CD\u9aa8\u67b6\u7684\u65b9\u6cd5\u7684\u6570\u91cf\u76f8\u5f53\u6709\u9650\u3002<\/p>\n

ii\uff09 \u5355\u4ef7\u7684\u73af\u7cca\u7cbe-\u836f\u7269\u4f53\u7cfb\u6eb6\u89e3\u548c\u9012\u9001\u4e0d\u7b26\u5408\u4e2a\u6027\u5316\u7cbe\u51c6\u533b\u5b66\u7684\u9ad8\u6807\u51c6\u3002\u6b64\u5916\uff0c\u6d89\u53ca\u4fee\u9970\u73af\u7cca\u7cbe\u7684\u9ad8\u5ea6\u53d7\u63a7\u7684\u5206\u5b50\u8bc6\u522b\uff08\u5982\u91d1\u521a\u70f7\u548c\u5076\u6c2e\u82ef\u5ba2\u4f53\u5206\u5b50\uff09\u5c1a\u672a\u5b8c\u5168\u7528\u4e8e\u751f\u7269\u533b\u5b66\u5e94\u7528\u3002<\/p>\n

iii\uff09 \u57fa\u4e8e\u73af\u7cca\u7cbe\u7684\u8d85\u5206\u5b50\u7ec4\u88c5\u4f53\u7684\u751f\u7269\u5b66\u529f\u80fd\u7814\u7a76\u5c40\u9650\u5728\u6297\u764c\u4e0a\uff0c\u800c\u56fd\u5185\u5916\u5bf9\u5fc3\u8111\u8840\u7ba1\u75be\u75c5\u7b49\u5176\u4ed6\u6025\u6162\u6027\u75c5\u7684\u6cbb\u7597\u7814\u7a76\u76f8\u5bf9\u8f83\u5c11\u3002<\/p>\n

iv\uff09 \u4e00\u4e9b\u76ee\u524d\u53ef\u7528\u7684\u8d85\u5206\u5b50\u7eb3\u7c73\u7ed3\u6784\u5728\u6750\u6599\u548c\u6210\u672c\u65b9\u9762\u5b58\u5728\u8fc7\u5ea6\u8bbe\u8ba1\u548c\u6d6a\u8d39\uff0c\u8feb\u5207\u9700\u8981\u7b80\u5316\u548c\u4f18\u5316\u57fa\u4e8e\u73af\u7cca\u7cbe\u7684\u751f\u7269\u529f\u80fd\u7eb3\u7c73\u7ed3\u6784\u7ec4\u6210\u3002<\/p>\n

v\uff09 \u5728\u8fd9\u4e9b\u523a\u6fc0\u54cd\u5e94\u578b\u7ec4\u88c5\u4f53\u4e2d\uff0c\u6c27\u5316\u8fd8\u539f\u548cpH\u503c\u7684\u53d8\u5316\u901a\u5e38\u4f1a\u5728\u4f53\u5185\u4ea7\u751f\u5316\u5b66\u5e9f\u6599\uff0c\u56e0\u6b64\u5149\u3001\u78c1\u7b49\u5176\u4ed6\u8fdc\u7a0b\u548c\u975e\u63a5\u89e6\u6027\u54cd\u5e94\u6709\u7740\u66f4\u6709\u524d\u666f\u7684\u7814\u7a76\u4ef7\u503c\u3002<\/p>\n

\n \u6587\u732e\u94fe\u63a5\uff1a Cyclodextrin-Based Multistimuli-Responsive Supramolecular Assemblies and Their Biological Functions <\/a>\uff08Adv. Mater.<\/em> 2019,<\/strong> 1806158\uff09<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u9ad8\u751f\u7ec4\u6211\u4ea6\u662f\u884c\u4eba\u7f16\u8bd1\uff0c\u6750\u6599\u4eba\u6574\u7406\u3002<\/p>\n

\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1\uff1atougao@cailiaoren.com.<\/a><\/p>\n

\u6295\u7a3f\u4ee5\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1acailiaokefu.<\/p>\n","protected":false},"excerpt":{"rendered":"

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