{"id":171982,"date":"2019-04-11T06:30:50","date_gmt":"2019-04-10T22:30:50","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=171982"},"modified":"2019-04-10T19:04:34","modified_gmt":"2019-04-10T11:04:34","slug":"%e3%80%90%e5%b7%b2%e6%a0%a1%e7%a8%bf%e3%80%91%e5%9b%bd%e5%ae%b6%e7%ba%b3%e7%b1%b3%e7%a7%91%e5%ad%a6%e4%b8%ad%e5%bf%83acs-nano-%e4%b8%80%e7%a7%8d%e5%8f%af%e6%8b%93%e5%b1%95%e7%9a%84%e6%98%9f%e5%bd%a2","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=171982","title":{"rendered":"\u56fd\u5bb6\u7eb3\u7c73\u79d1\u5b66\u4e2d\u5fc3ACS Nano: \u4e00\u79cd\u53ef\u62d3\u5c55\u7684\u661f\u5f62\u7eb3\u7c73\u5e73\u53f0\uff0c\u7528\u4e8e\u529f\u80fd\u548c\u89e3\u5256\u5b66\u6210\u50cf\u6307\u5bfc\u7684\u80bf\u7624\u5149\u70ed\u6cbb\u7597"},"content":{"rendered":"

\u3010\u80cc\u666f\u4ecb\u7ecd\u3011<\/strong><\/p>\n

\u6076\u6027\u80bf\u7624\u4f5c\u4e3a\u5168\u7403\u7b2c\u4e8c\u5927\u6b7b\u4ea1\u539f\u56e0\uff0c\u5df2\u7ecf\u6210\u4e3a\u6700\u4e3b\u8981\u7684\u516c\u5171\u536b\u751f\u5b89\u5168\u5a01\u80c1\u4e4b\u4e00\u3002\u591a\u6a21\u6001\u6210\u50cf\u53ef\u4ee5\u63d0\u4f9b\u80bf\u7624\u7684\u89e3\u5256\u5b66\u3001\u75c5\u7406\u5b66\u548c\u5206\u5b50\u5b66\u7b49\u4e92\u8865\u4fe1\u606f\uff0c\u5728\u51c6\u786e\u8bca\u65ad\u3001\u6307\u5bfc\u6cbb\u7597\u5e72\u9884\u3001\u836f\u7269\u793a\u8e2a\u548c\u76d1\u6d4b\u6cbb\u7597\u53cd\u5e94\u65b9\u9762\u6709\u7740\u826f\u597d\u7684\u524d\u666f\u3002X\u5c04\u7ebf\u8ba1\u7b97\u673a\u65ad\u5c42\u626b\u63cf\uff08CT\uff09\u662f\u4e00\u79cd\u9ad8\u5206\u8fa8\u7387\u3001\u65e0\u6df1\u5ea6\u9650\u5236\u3001\u53ef\u4e09\u7ef4\u91cd\u5efa\u7684\u6210\u50cf\u7cfb\u7edf\u3002\u78c1\u5171\u632f\u6210\u50cf\uff08MRI\uff09\u53ef\u4ee5\u63d0\u4f9b\u6e05\u6670\u7684\u8f6f\u7ec4\u7ec7\u7ed3\u6784\uff0c\u5177\u6709\u826f\u597d\u7684\u7a7a\u95f4\u5206\u8fa8\u7387\u3002\u5149\u58f0\u6210\u50cf\uff08PAI\uff09\u662f\u4e00\u79cd\u65b0\u5174\u7684\u3001\u57fa\u4e8e\u5149\u58f0\u6548\u5e94\u7684\u6210\u50cf\u65b9\u5f0f\uff0c\u5177\u6709\u8f83\u9ad8\u7684\u7a7a\u95f4\u5206\u8fa8\u7387\u548c\u5b9e\u65f6\u76d1\u6d4b\u80fd\u529b\u3002\u4e0e\u8fd9\u4e9b\u7ed3\u6784\u6210\u50cf\u65b9\u5f0f\u76f8\u6bd4\uff0c\u53ef\u6fc0\u6d3b\u8fd1\u7ea2\u5916\u8367\u5149\u6210\u50cf\uff08NIRFI\uff09\u662f\u4e00\u79cd\u975e\u5e38\u7406\u60f3\u7684\u529f\u80fd\u6210\u50cf\u65b9\u6cd5\uff0c\u7ecf\u5408\u7406\u8bbe\u8ba1\u80fd\u591f\u4ee5\u4f4e\u6210\u672c\u3001\u9ad8\u7279\u5f02\u3001\u9ad8\u7075\u654f\u7684\u65b9\u5f0f\uff0c\u5b9e\u73b0\u7279\u5b9a\u5206\u5b50\u8868\u8fbe\u548c\u6d3b\u6027\u7684\u53ef\u89c6\u5316\u5e76\u7528\u4e8e\u75c5\u7406\u68c0\u6d4b\u3002\u7531\u4e8e\u5355\u4e00\u6a21\u5f0f\u4e0d\u8db3\u4ee5\u63d0\u4f9b\u6240\u6709\u9700\u8981\u7684\u4fe1\u606f\uff0c\u901a\u8fc7\u5c06CT\u3001MRI\u3001PAI\u548cNIRF\u7b49\u591a\u79cd\u6210\u50cf\u6a21\u5f0f\u76f8\u7ed3\u5408\uff0c\u6574\u5408\u5176\u5404\u81ea\u7684\u4f18\u52bf\uff0c\u63d0\u4f9b\u4e92\u8865\u7684\u529f\u80fd\u548c\u89e3\u5256\u5b66\u4fe1\u606f\uff0c\u53ef\u4ee5\u66f4\u597d\u5730\u8fbe\u5230\u80bf\u7624\u51c6\u786e\u8bca\u65ad\u7684\u76ee\u7684\u3002\u8fd1\u5e74\u6765\uff0c\u57fa\u4e8e\u7eb3\u7c73\u6750\u6599\u7684\u591a\u6a21\u6001\u6210\u50cf\u5e73\u53f0\u5f15\u8d77\u4e86\u5e7f\u6cdb\u7684\u5173\u6ce8\uff0c\u5176\u4e2d\u517c\u5177\u6210\u50cf\u4e0e\u6cbb\u7597\u7279\u6027\u7684\u7eb3\u7c73\u6750\u6599\u5c24\u5177\u5438\u5f15\u529b\u3002\u76ee\u524d\u5df2\u6709\u7684\u591a\u6a21\u6001\u7eb3\u7c73\u8bca\u7597\u5e73\u53f0\u591a\u91c7\u53d6\u5c06\u6240\u6709\u5143\u7d20\u7b80\u5355\u6574\u5408\u7684\u201c\u4e00\u4f53\u5316\u201d\u7b56\u7565\uff0c\u4f46\u6784\u6210\u590d\u6742\u3001\u5408\u6210\u56f0\u96be\u3001\u7a33\u5b9a\u6027\u5dee\u548c\u6f5c\u5728\u7684\u5b89\u5168\u7b49\u95ee\u9898\u6781\u5927\u5730\u9650\u5236\u4e86\u8fd9\u4e9b\u7eb3\u7c73\u5e73\u53f0\u66f4\u4e3a\u5e7f\u6cdb\u7684\u751f\u7269\u533b\u5b66\u5e94\u7528\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u6700\u8fd1\uff0c\u56fd\u5bb6\u7eb3\u7c73\u79d1\u5b66\u4e2d\u5fc3\u8d75\u5b87\u4eae<\/strong>\u3001\u8042\u5e7f\u519b<\/strong>\uff0c\u674e\u4e00\u53f6\u7814\u7a76\u5458<\/strong>\u56e2\u961f\u5408\u4f5c\u62a5\u9053\u4e86\u4e00\u79cd\u53ef\u62d3\u5c55\u7684\u661f\u5f62\u7eb3\u7c73\u5e73\u53f0\uff0c\u5e76\u5c06\u5176\u7528\u4e8e\u529f\u80fd\u548c\u89e3\u5256\u5b66\u6210\u50cf\u6307\u5bfc\u7684\u80bf\u7624\u5149\u70ed\u6cbb\u7597\u3002\u4f5c\u8005\u57fa\u4e8e\u805a\u591a\u5df4\u80fa\u5305\u8986\u661f\u5f62\u91d1\u7eb3\u7c73\u7c92\uff08GNS@PDA\uff09\uff0c\u8bbe\u8ba1\u4e86\u4e00\u4e2a\u7b80\u5355\u800c\u529f\u80fd\u5f3a\u5927\u5e76\u6613\u4e8e\u591a\u79cd\u529f\u80fd\u62d3\u5c55\u7684\u7eb3\u7c73\u8bca\u7597\u5e73\u53f0\uff0c\u5b9e\u73b0\u4e86\u529f\u80fd\u548c\u89e3\u5256\u6210\u50cf\u6307\u5bfc\u7684\u80bf\u7624\u5149\u70ed\u6cbb\u7597\u3002\u8be5\u7eb3\u7c73\u5e73\u53f0\u652f\u6301CT\/ PAI \/\u53cc\u5149\u5b50\u8367\u5149\/\u70ed\u7ea2\u5916\u56db\u6a21\u6001\u6210\u50cf\uff0c\u5e76\u80fd\u8fdb\u4e00\u6b65\u62d3\u5c55\u6210\u7ea4\u7ef4\u7ec6\u80de\u6d3b\u5316\u86cb\u767d\uff08FAP\uff09\u6fc0\u6d3b\u7684NIRFI\u4ee5\u53ca\u57fa\u4e8eFe3+<\/sup>\u7684MRI\u8fdb\u884c\u80bf\u7624\u7efc\u5408\u8bca\u65ad\u3002\u6b64\u5916\uff0cGNS@PDA\u5177\u6709\u826f\u597d\u7684\u5149\u70ed\u6027\u80fd\uff0c\u53ef\u5728\u80bf\u7624\u7ec4\u7ec7\u9ad8\u6548\u5bcc\u96c6\u3002\u5728\u591a\u6a21\u6001\u6210\u50cf\u7684\u7cbe\u786e\u6307\u5bfc\u4e0b\uff0cGNS@PDA\u5728\u5f02\u79cd\u79fb\u690d\u5c0f\u9f20\u80bf\u7624\u6a21\u578b\u4e2d\u5b9e\u73b0\u4e86\u5bf9\u5b9e\u4f53\u7624(\u223c200 mm3<\/sup>)\u7684\u5149\u70ed\u6d88\u878d\u3002\u8be5\u7814\u7a76\u53d1\u5c55\u7684\u53ef\u62d3\u5c55\u7eb3\u7c73\u5e73\u53f0\u6709\u671b\u7528\u4e8e\u764c\u75c7\u7684\u591a\u6a21\u6001\u8bca\u7597\u3002\u76f8\u5173\u6210\u679c\u4ee5\u201cAn Extendable Star-Like Nanoplatform for Functional and Anatomical Imaging-Guided Photothermal Oncotherapy<\/strong>\u201d\u53d1\u8868\u4e8e\u77e5\u540d\u5b66\u672f\u671f\u520aACS Nano<\/strong>\u3002<\/p>\n

\u3010\u56fe\u6587\u6458\u8981\u3011<\/strong><\/p>\n

\u529f\u80fd\u548c\u89e3\u5256\u5b66\u6210\u50cf\u6307\u5bfc\u7684\u53ef\u62d3\u5c55\u80bf\u7624\u7eb3\u7c73\u8bca\u7597\u5e73\u53f0<\/strong>
\n \"\"\"\"\uff08a\uff09GNS@PDA\u7eb3\u7c73\u5e73\u53f0\u7684\u6784\u5efa\u4e0e\u529f\u80fd\u62d3\u5c55;<\/p>\n

\uff08b\uff09\u57fa\u4e8eGNS @ PDA\u7eb3\u7c73\u8bca\u7597\u5e73\u53f0\u7528\u4e8e\u8fd1\u7ea2\u5916\u8367\u5149\uff08NIRF\uff09\u3001\u5149\u58f0\uff08PA\uff09\u3001\u78c1\u5171\u632f\uff08MR\uff09\u3001\u8ba1\u7b97\u673a\u65ad\u5c42\u626b\u63cf\uff08CT\uff09\u3001\u53cc\u5149\u5b50\u53d1\u5149\uff08TPL\uff09\u548c\u70ed\u7ea2\u5916\uff08 IRT\uff09\u6210\u50cf\u6307\u5bfc\u7684\u80bf\u7624\u5149\u70ed\u6cbb\u7597\uff08PTT\uff09\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe\u4e00\u3001\u7eb3\u7c73\u5e73\u53f0\u7684\u8868\u5f81\u548c\u4f53\u5916NIRF\u6fc0\u6d3b<\/strong>
\n \"\"\uff08a\uff09GNS@PDA\u7684TEM\u56fe\u3002\u6807\u5c3a\uff1a100 \u03bcm\u3002\u63d2\u56fe\u4e3a\u653e\u5927\u56fe\uff0c\u6807\u5c3a\uff1a20 \u03bcm\uff1b<\/p>\n

\uff08b\uff09Cy7\u80bd\u3001GNS@PDA\u548cGNS@PDA-Cy7\u6eb6\u6db2\u7684\u7d2b\u5916-\u53ef\u89c1\u5438\u6536\u5149\u8c31\uff1b<\/p>\n

\uff08c\uff09GNS@PDA\u3001GNS@PDA-Cy7\u548cCy7\u80bd\u6eb6\u6db2\u7684\u660e\u573a\u548cNIRF\u56fe\uff1b<\/p>\n

\uff08d\uff09Cy7\u80bd\u3001GNS@PDA\u3001GNS@PDA-Cy7\u6eb6\u6db2\u7684NIRF\u53d1\u5c04\u5149\u8c31\uff1b<\/p>\n

\uff08e\uff09\u4e0eHPNE\u6216Mia-paca-2\u7ec6\u80de\u5b75\u80b26 h\u540e\uff0cGNS@PDA-Cy7\u7684NIRF\u53d1\u5c04\u5149\u8c31;<\/p>\n

\uff08f\uff09\u4e0eMia-paca-2\u7ec6\u80de\u5171\u5b75\u80b2\u4e0d\u540c\u65f6\u95f4\u540e\uff0cGNS@PDA-Cy7\u7684NIRF\u53d1\u5c04\u5149\u8c31\u3002\u63d2\u56fe\u4e3a\u4e0a\u6e05\u6db2\u7684NIRF\u56fe\u50cf\uff1b<\/p>\n

\uff08g\uff09\u4e0eGNS@PDA-Cy7\u5171\u5b75\u80b2\u4e0d\u540c\u65f6\u95f4\u540e\uff0cMiapaca-2\u7ec6\u80de\u7684\u6d41\u5f0f\u7ec6\u80de\u5206\u6790\u7ed3\u679c\uff1b<\/p>\n

\uff08h\uff09\u4e0eGNS@PDA-Cy7\u5171\u5b75\u80b2\u4e0d\u540c\u65f6\u95f4\u540e\uff0cMia-paca-2\u7ec6\u80de\u5e73\u5747\u8367\u5149\u5f3a\u5ea6\uff08MFI\uff09\uff1b<\/p>\n

\uff08i\uff09\u4e0eGNS@PDA-Cy7\u5171\u5b75\u80b2\u540e\uff0c\u4e0d\u540c\u6570\u91cfMia-paca-2\u7ec6\u80de\u7684NIRF\u53d1\u5c04\u5149\u8c31\u3002Ex<\/sub> = 740 nm\u3002<\/p>\n

\u56fe\u4e8c\u3001\u7eb3\u7c73\u5e73\u53f0\u7684\u5149\u70ed\u7279\u6027<\/strong>
\n \"\"\uff08a\uff09\u8fd1\u7ea2\u5916\u6fc0\u5149\uff08808 nm\uff0c1.4 W\/cm2<\/sup>\uff09\u7167\u5c04\u540e\uff0cGNS@PDA\uff080~100 \u03bcg \/mL\uff09\u7684\u6e29\u5ea6\u53d8\u5316\uff1b<\/p>\n

\uff08b\uff09\u6fc0\u5149\u8f90\u7167\u8fc7\u7a0b\u4e2dGNS@PDA\u7684\u7ea2\u5916\u70ed\u56fe\uff1b<\/p>\n

\uff08c\uff09\u4e0d\u540c\u5149\u529f\u7387\u5bc6\u5ea6\uff080.7 W\/cm2<\/sup>\uff0c1.4 W\/cm2<\/sup>\uff0c2.8 W\/cm2<\/sup>\uff09\u8fd1\u7ea2\u5916\u6fc0\u5149\u7167\u5c04\u4e0b\uff0cGNS@PDA\u7684\u6e29\u5ea6\u53d8\u5316\uff1b<\/p>\n

\uff08d\uff09GNS@PDA\u7684\u5347\u6e29\u548c\u51b7\u5374\u66f2\u7ebf\uff1b<\/p>\n

\uff08e\uff09\u51b7\u5374\u65f6\u95f4\u4e0e\u6e29\u5ea6\u5dee\u7684\u8d1f\u81ea\u7136\u5bf9\u6570\u5173\u7cfb\u56fe\uff1b<\/p>\n

\uff08f\uff09\u4e09\u4e2a\u6fc0\u5149\u8f90\u7167\u5f00\/\u5173\u5faa\u73af\u5185\uff0cGNS@PDA\u548cGNS-PEG\u7684\u6e29\u5ea6\u53d8\u5316\u3002<\/p>\n

\u56fe\u4e09\u3001\u7eb3\u7c73\u5e73\u53f0\u7684\u4f53\u5916\u5149\u70ed\u6cbb\u7597<\/strong>
\n \"\"\uff08a\uff09Mia-paca-2\u7ec6\u80de\u7ecfGNS@PDA\u6216GNS-PEG\u5904\u7406\u540e\u7684\u53cc\u5149\u5b50\u53d1\u5149\uff08TPL\uff09\u56fe\u3002\u6807\u5c3a\uff1a20 \u03bcm\uff1b<\/p>\n

\uff08b\uff09\u5149\u70ed\u6cbb\u7597\u540e\uff0cMia-paca-2\u7ec6\u80de\u7ecf\u9499\u9ec4\u7eff\u7d20\uff08AM\uff0c\u7eff\u8272\uff09\u548c\u7898\u5316\u4e19\u5576\uff08PI\uff0c\u7ea2\u8272\uff09\u67d3\u8272\u7684\u8367\u5149\u56fe\u3002\u6807\u5c3a\uff1a100 \u03bcm\uff1b<\/p>\n

\uff08c\uff09\u6fc0\u5149\u7167\u5c04\u540e\uff0cGNS@PDA\u6216GNS-PEG\u5bf9Mia-paca-2\u7ec6\u80de\u7684\u5149\u70ed\u6740\u4f24\uff1b<\/p>\n

\uff08d\uff09GNS@PDA\u6216GNS-PEG\u7a7f\u900fMia-paca-2\u7ec6\u80de\u7403\uff08Mia-SS\uff09\u7684TPL\u56fe\u50cf\uff1b<\/p>\n

\uff08e\uff09\u6fc0\u5149\u7167\u5c04\u540e\uff0cPI\u67d3\u8272\u7684Mia-SS\u8367\u5149\u56fe\u53ca\u5176\u4e09\u7ef4\u91cd\u5efa\u56fe\u3002\u6807\u5c3a\uff1a100 \u03bcm\u3002<\/p>\n

\u56fe\u56db\u3001\u7eb3\u7c73\u5e73\u53f0\u7684\u4f53\u5185\u89e3\u5256\u5b66\uff08CT\/PA\/MR\uff09\u548c\u529f\u80fd\uff08NIRF\uff09\u6210\u50cf<\/strong>
\n \"\"\uff08a\uff09\u7624\u5185\u6ce8\u5c04GNS@PDA\u524d\u540e\u8377\u7624\u5c0f\u9f20\u7684\u4e09\u7ef4\u91cd\u5efaCT\u6210\u50cf\uff1b<\/p>\n

\uff08b\uff09\u9759\u8109\u6ce8\u5c04GNS@PDA\u6216GNS-PEG\u540e\uff0c\u8377\u7624\u5c0f\u9f20\u7684PA\u6210\u50cf\uff1b<\/p>\n

\uff08c\uff09\u80bf\u7624\u90e8\u4f4dPA\u5f3a\u5ea6\u7684\u5b9a\u91cf\u5206\u6790\uff1b<\/p>\n

\uff08d\uff09\u9759\u8109\u6ce8\u5c04GNS@PDA-Fe\u540e\uff0c\u8377\u7624\u5c0f\u9f20\u7684MR\u6210\u50cf\uff1b<\/p>\n

\uff08e\uff09\u9759\u8109\u6ce8\u5c04\u751f\u7406\u76d0\u6c34\uff08\u5de6\u9f20\uff09\u6216GNS@PDA-Cy7\uff08\u53f3\u9f20\uff09\u540e\uff0c\u8377\u7624\u5c0f\u9f20\u7684NIRF\u6210\u50cf\uff1b<\/p>\n

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\uff08g\uff09\u9759\u8109\u6ce8\u5c04GNS@PDA-Cy7\u540e\uff0c\u5c0f\u9f20\u80bf\u7624\u53ca\u4e3b\u8981\u5668\u5b98\u7684\u79bb\u4f53NIRF\u6210\u50cf\uff1b<\/p>\n

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\n \u6587\u732e\u94fe\u63a5\uff1aAn Extendable Star-Like Nanoplatform for Functional and Anatomical Imaging-Guided Photothermal Oncotherapy<\/a>\uff08ACS Nano.<\/em> 2019.<\/strong> DOI\uff1a10.1021\/acsnano.8b09607\uff09<\/p>\n

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