{"id":172350,"date":"2019-04-17T06:30:15","date_gmt":"2019-04-16T22:30:15","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=172350"},"modified":"2019-04-16T17:03:00","modified_gmt":"2019-04-16T09:03:00","slug":"%e5%b7%b2%e6%a0%a1%e7%a8%bf%e4%bb%b6-%e4%b8%ad%e5%9b%bd%e8%8d%af%e7%a7%91%e5%a4%a7%e5%ad%a6-nano-lett-%e6%8a%a5%e9%81%93-%e7%ba%b3%e7%b1%b3%e9%85%8d%e4%bd%8d%e8%81%9a%e5%90%88%e7%89%a9%e5%8d%8f","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=172350","title":{"rendered":"\u4e2d\u56fd\u836f\u79d1\u5927\u5b66 Nano Lett.\u62a5\u9053: \u7eb3\u7c73\u914d\u4f4d\u805a\u5408\u7269\u534f\u540cNO\u548c\u5316\u5b66\u52a8\u529b\u5b66\u7528\u4e8e\u6cbb\u7597\u809d\u764c"},"content":{"rendered":"

\u3010\u80cc\u666f\u4ecb\u7ecd\u3011<\/strong><\/p>\n

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\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u6700\u8fd1\uff0c\u4e2d\u56fd\u836f\u79d1\u5927\u5b66\u7684\u4e01\u5a05\u6559\u6388\u548c\u9ec4\u5f20\u5efa\u7814\u7a76\u5458\uff08\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u7b49\u4eba\u62a5\u9053\u4e86\u4e00\u79cd\u8c37\u80f1\u7518\u80bd\uff08GSH\uff09\u654f\u611f\u7684NO\u4f9b\u4f53{1, 5-\u53cc[(L-\u812f\u6c28\u9178-1-\u57fa)\u4e8c\u6c2e\u70ef-1-\u9393-1, 2-\u4e8c\u9187-O2-\u57fa] -2,4-\u4e8c\u785d\u57fa\u82ef\uff0cBPDB }\uff0c\u901a\u8fc7\u7b80\u5355\u7684\u6c89\u6dc0\u548c\u79bb\u5b50\u4ea4\u6362\u8fc7\u7a0b\uff0c\u4e0e\u94c1\u79bb\u5b50\u914d\u4f4d\u5f62\u6210\u7eb3\u7c73\u914d\u4f4d\u805a\u5408\u7269\uff08NCP\uff09\uff0c\u63d0\u9ad8\u4e86NO\u7684\u7cbe\u786e\u9776\u5411\u6027\u548c\u534f\u540c\u6cbb\u7597\u6548\u679c\u3002\u5176\u4e2d\uff0c\u6240\u5236\u5907\u7684Fe(II)-BNCP\u5177\u6709\u826f\u597d\u7684\u6eb6\u89e3\u6027\u3001\u751f\u7269\u76f8\u5bb9\u6027\u548c\u4f53\u5185\u5faa\u73af\u7a33\u5b9a\u6027\u3002\u805a\u5408\u7269\u7ed3\u6784\u4e2d\u7684NO\u4f9b\u4f53\u5728\u80bf\u7624\u7ec6\u80de\u5185\u9ad8\u6d53\u5ea6\u8c37\u80f1\u7518\u80bd\u6761\u4ef6\u4e0b\u5feb\u901f\u91ca\u653eNO\uff0c\u4e9a\u94c1\u79bb\u5b50\u5728\u80bf\u7624\u9ad8\u6d53\u5ea6H2<\/sub>O2<\/sub>\u5fae\u73af\u5883\u6761\u4ef6\u4e0b\u901a\u8fc7Fenton\u53cd\u5e94\u548cHaber-Weiss\u53cd\u5e94\u5206\u522b\u4ea7\u751f\u7f9f\u81ea\u7531\u57fa\u548c\u8fc7\u6c27\u81ea\u7531\u57fa\u3002\u7f9f\u81ea\u7531\u57fa\u53d1\u6325\u5316\u5b66\u52a8\u529b\u5b66\u6cbb\u7597\uff08CDT\uff09\u529f\u6548\uff1b\u8fc7\u6c27\u81ea\u7531\u57fa\u4e0e\u91ca\u653e\u51fa\u7684NO\u8fc5\u901f\u53cd\u5e94\u751f\u6210\u6c27\u5316\u80fd\u529b\u66f4\u5f3a\u7684\u8fc7\u6c27\u4e9a\u785d\u57fa\u9634\u79bb\u5b50\uff0c\u589e\u5f3aNO\u7684\u6cbb\u7597\u6d3b\u6027\u3002\u7f9f\u81ea\u7531\u57fa\u548c\u8fc7\u6c27\u4e9a\u785d\u57fa\u9634\u79bb\u5b50\u53d1\u6325\u5316\u5b66\u52a8\u529b\u5b66\u548cNO\u7684\u534f\u540c\u6cbb\u7597\u6548\u679c\u3002\u901a\u8fc7\u5bf9\u4e0a\u8ff0\u5404\u79cd\u81ea\u7531\u57fa\u7684\u68c0\u6d4b\uff0c\u6e05\u6670\u5730\u9610\u660e\u4e86\u534f\u540c\u673a\u5236\u3002\u4e0e\u6b63\u5e38\u809d\u7ec6\u80de\u76f8\u6bd4\uff0c\u805a\u5408\u7269\u5177\u6709\u809d\u80bf\u7624\u7ec6\u80de\u9776\u5411\u81ea\u7531\u57fa\u91ca\u653e\u80fd\u529b\uff1b\u5728\u5c0f\u9f20\u809d\u79fb\u690d\u7624\u6a21\u578b\u4e2d\uff0c\u8868\u73b0\u51faCDT\u4e0eNO\u534f\u540c\u589e\u5f3a\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u4e14\u5bf9\u6b63\u5e38\u7ec4\u7ec7\/\u7ec6\u80de\u7684\u6bd2\u6027\u8f83\u5c0f\u3002\u8be5\u7814\u7a76\u4e0d\u4ec5\u5b9e\u73b0\u4e86NO-CDT\u7597\u6cd5\u7684\u534f\u540c\u6548\u5e94\uff0c\u800c\u4e14\u8fd8\u63d0\u4f9b\u4e86\u4e00\u79cd\u901a\u8fc7\u5408\u7406\u8bbe\u8ba1\u524d\u836f\u5206\u5b50\uff08\u4f8b\u5982NO\u4f9b\u4f53\uff09\u6784\u5efa\u7684\u7eb3\u7c73\u914d\u4f4d\u805a\u5408\u7269\u5b9e\u73b0\u7279\u5f02\u6027\u7684\u3001\u7b80\u5355\u4e14\u6709\u6548\u7684\u7eb3\u7c73\u7ed9\u836f\u7b56\u7565\u3002\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a\u201cNanoscale Coordination Polymers for Synergistic NO and Chemo-dynamic Therapy of Liver Cancer\u201d<\/strong>\u53d1\u5e03\u5728\u8457\u540d\u671f\u520aNano Lett.<\/strong>\u4e0a\u3002
\n \"\"
\n \u3010\u56fe\u6587\u89e3\u8bfb\u3011<\/strong><\/p>\n

\u56fe\u4e00\u3001Fe(II)-BNCP\u7684\u5236\u5907\u548c\u4f5c\u7528\u673a\u5236<\/strong>
\n \"\"\uff08A\uff09 Fe(III)-BNCP\u548cFe(II)-BNCP\u5236\u5242\u7684\u5236\u5907\u8fc7\u7a0b\uff1b<\/p>\n

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\n \"\"\uff08A\uff09 \u4e0d\u540cGSH\u6c34\u5e73\u7684\u91ca\u653e\u91cf\uff1b<\/p>\n

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\uff08D\uff09 Zn(II)-DNCP\u3001Fe(II)-DNCP\u3001Zn(II)-BNCP\u548cFe(II)-BNCP\u5728400 \u03bcM H2<\/sub>O2<\/sub>\u65f6\u4ea7\u751fONOO–<\/sup>\u7684\u91cf\u3002<\/p>\n

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\n \"\"\uff08A\uff09\u6cbb\u759712\u5929\u540e\uff0c\u80bf\u7624\u4f53\u79ef\u53d8\u5316\u56fe\uff1b<\/p>\n

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\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

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\u6587\u732e\u94fe\u63a5\uff1aNanoscale Coordination Polymers for Synergistic NO and<\/a><\/strong>
\n Chemo-dynamic Therapy of Liver Cancer<\/strong><\/a>\uff08Nano Lett., 2019<\/strong>, DOI: 10.1021\/acs.nanolett.9b01093\uff09<\/p>\n

\u901a\u8baf\u4f5c\u8005\u7b80\u4ecb<\/strong><\/p>\n

\"\"<\/p>\n

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\"\"<\/p>\n

\u9ec4\u5f20\u5efa\uff0c\u7814\u7a76\u5458\uff0c\u535a\u58eb\u751f\u5bfc\u5e08\u3002\u56fd\u5bb6\u4f18\u9752\uff082018\uff09\uff0c\u6c5f\u82cf\u7701\u6770\u9752\uff082016\uff09\uff0c\u6559\u80b2\u90e8\u65b0\u4e16\u7eaa\u4f18\u79c0\u4eba\u624d\uff082013\uff09\u3002<\/strong>\u8fd1\u5e74\u5728\u836f\u7269\u5316\u5b66\u3001\u5316\u5b66\u53ca\u76f8\u5173\u9886\u57df\u6742\u5fd7Journal of Medicinal Chemistry, Advanced Materials\uff0cChemical Science\u7b49\u53d1\u8868SCI\u79d1\u7814\u8bba\u658750\u4f59\u7bc7\uff0c\u5176\u4e2d\u836f\u7269\u5316\u5b66\u9886\u57df\u4e00\u533a\u6742\u5fd7Journal of Medicinal Chemistry \u4e0a\u53d1\u886813\u7bc7\u3002\u7533\u8bf7\u4e2d\u56fd\u53d1\u660e\u4e13\u522915\u9879\uff0c\u5df2\u83b7\u6388\u67436\u9879\uff0c\u7533\u8bf7PCT\u4e13\u52291\u9879\uff1b\u4e3b\u6301\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d14\u9879\uff1b\u91cd\u5927\u65b0\u836f\u521b\u5236\u79d1\u6280\u91cd\u5927\u4e13\u9879\u5b50\u4efb\u52a11\u9879\uff1b2014\u5e74\u83b7\u5f97\u4e2d\u56fd\u836f\u5b66\u4f1a-\u65bd\u7ef4\u96c5\u9752\u5e74\u836f\u7269\u5316\u5b66\u5956\uff0c2014\u5e74\u6c5f\u82cf\u7701\u53cc\u521b\u8ba1\u5212\u56e2\u961f\u6838\u5fc3\u6210\u5458\uff0c2016\u5e74\u6c5f\u82cf\u7701\u201c333\u201d\u5de5\u7a0b\u7b2c\u4e09\u6279\u57f9\u517b\u5bf9\u8c61\u3002<\/p>\n

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