{"id":173683,"date":"2019-05-01T06:30:34","date_gmt":"2019-04-30T22:30:34","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=173683"},"modified":"2019-04-30T18:19:56","modified_gmt":"2019-04-30T10:19:56","slug":"%e5%b7%b2%e6%a0%a1%e7%a8%bf%e4%bb%b6-%e4%b8%ad%e5%b1%b1%e5%a4%a7%e5%ad%a6%e7%ad%89%e4%b8%89%e6%96%b9-nano-lett-%e6%8a%a5%e9%81%93-%e7%94%9f%e7%89%a9%e5%a4%96%e6%b3%8c%e4%bd%93%e9%a9%b1%e5%8a%a8","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=173683","title":{"rendered":"\u4e2d\u5c71\u5927\u5b66\u7b49\u4e09\u65b9 Nano Lett.\u62a5\u9053: \u751f\u7269\u5916\u6ccc\u4f53\u9a71\u52a8\u5bf9\u63a5\u7eb3\u7c73\u9897\u7c92\u5bf9\u539f\u4f4d\u4e73\u817a\u764c\u80ba\u8f6c\u79fb\u7684\u7279\u5f02\u6027\u5316\u7597"},"content":{"rendered":"

\u3010\u80cc\u666f\u4ecb\u7ecd\u3011<\/strong><\/p>\n

\u00a0 \u00a0 \u00a0 \u00a0 \u4f17\u6240\u5468\u77e5\uff0c\u51b3\u5b9a\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u548c\u53cd\u5e94\u7684\u836f\u7269\u8fc7\u7a0b\uff0c\u5728\u836f\u7269\u5206\u5b50\u8fdb\u5165\u4eba\u4f53\u5185\u540e\u5c31\u663e\u5f97\u975e\u5e38\u91cd\u8981\u3002\u8fd9\u79cd\u76f8\u4e92\u4f5c\u7528\u5305\u62ec\u836f\u7269\u4e0e\u751f\u7269\u9776\u6807\u7684\u7ed3\u5408\u3001\u836f\u7269\u4e0e\u8840\u6d46\u86cb\u767d\u7684\u7ed3\u5408\u7b49\u7b49\u3002\u5176\u4e2d\uff0c\u7531585\u4e2a\u6c28\u57fa\u9178\u7ec4\u6210\u7684\u4eba\u8840\u6e05\u767d\u86cb\u767d\uff08HSA\uff09\u662f\u8840\u6d46\u4e2d\u6700\u4e30\u5bcc\u7684\u86cb\u767d\u8d28\uff0c\u5177\u6709\u4e09\u4e2a\u7ed3\u6784\u540c\u6e90\u7684\u7ed3\u6784\u57df\uff0c\u53ef\u4ee5\u5f88\u5bb9\u6613\u5730\u63a5\u53d7\u5316\u5b66\u7269\u8d28\u4f5c\u4e3a\u4f9b\u4f53\u3002\u56e0\u6b64\uff0c\u5b83\u5728\u51b3\u5b9a\u5404\u79cd\u5185\u6e90\u6027\u548c\u5916\u6e90\u6027\u7269\u8d28\u4ee5\u53ca\u6cbb\u7597\u5242\u7684\u914d\u7f6e\u65b9\u9762\u8d77\u7740\u91cd\u8981\u4f5c\u7528\u3002\u901a\u5e38\uff0c\u987aPt\u548cHSA\u4e4b\u95f4\u7684\u53cd\u5e94\u88ab\u8ba4\u4e3a\u662f\u94c2\uff08Pt\uff09\u5728\u8840\u6d46\u4e2d\u7ed3\u5408\u7684\u4e3b\u8981\u9014\u5f84\u3002\u4f46\u5b83\u4eec\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u662f\u4e0d\u53ef\u9006\u7684\uff0c\u5bfc\u81f4\u5176\u4ea7\u7269\u5728\u6cbb\u7597\u4e0a\u6ca1\u6709\u6d3b\u6027\u3002\u867d\u7136\u901a\u8fc7\u5728\u8f74\u5411\u4f4d\u7f6e\u5f15\u5165\u529f\u80fd\u5316\u914d\u4f53\uff0c\u5236\u5907\u7684\u65b0\u4e00\u4ee3Pt\u914d\u5408\u7269-Pt(IV)\u524d\u836f\u5728\u7ec6\u80de\u6eb6\u8d28\u8fd8\u539f\u4f5c\u7528\u4e0b\uff0cPt(IV)\u524d\u836f\u53ef\u5206\u89e3\u6210\u6709\u6bd2\u7684Pt(II)\u836f\u7269\u3002\u4f8b\u5982Pt(IV)\u524d\u836f\u88ab\u8d1f\u8f7d\u5728\u805a\u534a\u80f1\u6c28\u9178\u57fa(\u4e8c\u786b\u9170\u80fa)\u7eb3\u7c73\u8f7d\u4f53\u4e0a\uff0c\u901a\u8fc7\u4e8c\u786b\u952e\u54cd\u5e94GSH\uff0c\u6709\u671b\u514b\u670d\u5f02\u79cd\u79fb\u690d\u7624\u4e2d\u987aPt\u7684\u8010\u836f\u6027\u95ee\u9898\u3002\u4f46\u662f\u5728\u4e0d\u540c\u7684\u5f00\u53d1\u9636\u6bb5\u4ecd\u65e7\u5b58\u5728\u8fc7\u65e9\u91ca\u653e\u3001\u975e\u7279\u5f02\u6027\u5206\u5e03\u548c\u751f\u7269\u76f8\u5bb9\u6027\u5dee\u7b49\u6311\u6218\u3002<\/p>\n

\u00a0 \u00a0 \u00a0 \u00a0 \u7136\u800c\uff0c\u5de8\u566c\u7ec6\u80de\u4f5c\u4e3a\u6700\u4e30\u5bcc\u7684\u5faa\u73af\u7ec6\u80de\u4e4b\u4e00\uff0c\u53ef\u4ee5\u4f18\u5148\u88ab\u4e73\u817a\u764c\u5438\u6536\u4ee5\u52a0\u901f\u6076\u6027\u8f6c\u79fb\uff0c\u5728\u539f\u4f4d\u80bf\u7624\u4e2d\u5360\u636e\u4e00\u534a\u4ee5\u4e0a\u7684\u7ec6\u80de\u6570\u91cf\u3002\u5176\u4e2d\uff0c\u5916\u6ccc\u4f53\u662f\u7531\u54fa\u4e73\u52a8\u7269\u7ec6\u80de\u901a\u8fc7\u591a\u80de\u4f53\u4e0e\u8d28\u819c\u878d\u5408\u800c\u4e3b\u52a8\u5206\u6ccc\u768440-150 nm\u819c\u5305\u88f9\u5c0f\u6ce1\uff0c\u662f\u4e13\u95e8\u4ece\u4e8b\u7ec6\u80de\u95f4\u7684\u8fdc\u8ddd\u79bb\u901a\u8baf\uff0c\u4fc3\u8fdb\u86cb\u767d\u8d28\u548c\/\u6216\u6838\u9178\u7684\u8f6c\u79fb\uff0c\u4ee5\u4fbf\u5728\u53d7\u4f53\u7ec6\u80de\u4e2d\u8fdb\u884c\u540e\u7eed\u8c03\u63a7\u3002\u6b64\u5916\uff0c\u5728\u4f53\u6db2\u4e2d\u5177\u6709\u589e\u5f3a\u7a33\u5b9a\u6027\u7684\u540c\u79cd\u5f02\u4f53\u5916\u6ccc\u4f53\u53ef\u4ee5\u4f5c\u4e3a\u5408\u5e76\u8d27\u7269\u7684\u9690\u5f62\u6597\u7bf7\uff0c\u51cf\u5c11\u5355\u6838\u541e\u566c\u7ec6\u80de\u7cfb\u7edf(MPS)\u7684\u6e05\u9664\uff0c\u53ef\u4ee5\u907f\u514d\u6bd2\u6027\u548c\u514d\u75ab\u539f\u6027\u3002\u7531\u4e8e\u5de8\u566c\u7ec6\u80de\u6765\u6e90\u7684\u5916\u6ccc\u4f53\u5177\u6709\u72ec\u7279\u7684\u80bf\u7624\u5f52\u5de2\u80fd\u529b\uff0c\u6240\u4ee5\u5176\u4f5c\u4e3a\u836f\u7269\u9012\u9001\u5e73\u53f0\u53ef\u80fd\u662f\u5bf9\u4e73\u817a\u764c\u8fdb\u884c\u9776\u5411\u6027\u6cbb\u7597\u7684\u4e00\u4e2a\u6f5c\u5728\u7b56\u7565\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u00a0 \u00a0 \u00a0 \u00a0 \u00a0\u8fd1\u65e5\uff0c\u4e2d\u5c71\u5927\u5b66\u7684\u5434\u94a7\u6559\u6388\u53ca\u5408\u4f5c\u65b9\u8054\u5408<\/strong>\u62a5\u9053\u4e86\u4e00\u79cd\u901a\u8fc7\u5efa\u6a21\u8ba1\u7b97\u9884\u6d4b\u7531\u6708\u6842\u9178\u5b98\u80fd\u5316\u7684Pt(IV)\u524d\u836f[Pt(lau)]\u3001\u4eba\u8840\u6e05\u767d\u86cb\u767d\uff08HSA\uff09\u548c\u5375\u78f7\u8102\u7ec4\u6210\u7684\uff0c\u901a\u8fc7\u7eb3\u7c73\u6c89\u6dc0\u5236\u5907\u7684\u6700\u4f73\u5bf9\u63a5\u7eb3\u7c73\u9897\u7c92\uff08NPs\uff09\uff0c\u5e76\u901a\u8fc7\u8367\u5149\u5149\u8c31\u8fdb\u884c\u9a8c\u8bc1\u3002\u7136\u540e\uff0c\u4f5c\u8005\u8fdb\u4e00\u6b65\u8bbe\u8ba1\u4e86\u4e00\u79cd\u751f\u7269\u6fc0\u53d1\u7684\u5de8\u566c\u7ec6\u80de\u884d\u751f\u7684\u88ab\u79f0\u4e3aRex\u7684\u5916\u6ccc\u4f53\uff0c\u4f5c\u4e3a\u5bf9\u63a5NPs\u7684\u80bf\u7624\u7279\u5f02\u6027\u7a7f\u68ad\u7684\u8f7d\u4f53\u3002\u901a\u8fc7\u4f7fPt(lau)HSA NPs\u548cRex\u7684\u6df7\u5408\u7269\u8fdb\u884c\u5faa\u73af\u8d85\u58f0\u5904\u7406\u548c\u5feb\u901f\u8d85\u901f\u79bb\u5fc3\u5236\u5907\u51faNPs\/Rex\u3002\u8fd9\u79cd\u9ad8\u6027\u80fd\u7684NPs\/Rex\u8f93\u9001\u7cfb\u7edf\u53ef\u4ee5\u589e\u5f3a\u7684\u80f6\u4f53\u7a33\u5b9a\u6027\u548c\u6c27\u5316\u8fd8\u539f\u89e6\u53d1\u7684\u91ca\u653e\u66f2\u7ebf\u3002\u5229\u7528\u7ec6\u80de\u52a8\u529b\u5b66\u7684\u7814\u7a76\uff0c\u8bc1\u660eNPs\/Rex\u662f\u901a\u8fc7\u591a\u79cd\u9014\u5f84\u5185\u5316\uff0c\u907f\u514d\u4e86\u53cc\u5c42\u5305\u57cb\uff0c\u5e76\u4e14\u5728\u80de\u8d28\u6eb6\u80f6\u4e2d\u751f\u7269\u8fd8\u539f\u540e\u6210\u529f\u5730\u5236\u6210\u4e86Pt\u5316\u6838\u9178\u3002\u901a\u8fc7\u89c2\u5bdf\u987aPt\u5bf9NPs\/Rex\u5904\u7406\u540e\u7ec6\u80de\u589e\u6b96\u548c\u7ec6\u80de\u5468\u671f\u7684\u7279\u5f02\u6027\u4f5c\u7528\uff0c\u8bc1\u5b9e\u4e86Pt(lau)\u7684\u7ec6\u80de\u5185\u6d3b\u5316\u3002\u5728\u4f53\u5185\u5e94\u7528\u4e2d\uff0c\u4eff\u751f\u6d82\u5c42\u8d4b\u4e88\u5bf9\u63a5\u5177\u6709\u5ef6\u957f\u7684\u8840\u6db2\u5faa\u73af\u3001\u9776\u5411\u6027\u548c\u589e\u5f3a\u7684\u751f\u7269\u76f8\u5bb9\u6027\u4ee5\u53caNPs\u4e2d\u7684\u987aPt\u5316\u7597\u4e73\u817a\u764c\u7ec6\u80de\u4e2d\u7684\u8102\u80aa\u57ab\u548c\u80ba\u7684\u8f6c\u79fb\u7ed3\u8282\u539f\u4f4d\u80bf\u7624\u3002\u56e0\u6b64\uff0c\u8fd9\u79cd\u6709\u5229\u7684\u7eb3\u7c73\u5e73\u53f0\u53ef\u80fd\u4e3a\u76ee\u524d\u4e34\u5e8a\u4e0a\u4f7f\u7528\u7684Pt\u6297\u764c\u836f\u7269\u7684\u884d\u751f\u5316\u548c\u5f00\u53d1\u63d0\u4f9b\u4e00\u79cd\u6709\u4ef7\u503c\u7684\u65b9\u6cd5\u3002\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a\u201cPursuing Specific Chemotherapy of Orthotopic Breast Cancer with Lung Metastasis from Docking Nanoparticles Driven by Bioinspired Exosomes\u201d<\/strong>\u53d1\u5e03\u5728\u8457\u540d\u671f\u520aNano Lett.<\/strong>\u4e0a\u3002<\/p>\n

\u4e2d\u5c71\u5927\u5b66\u751f\u7269\u533b\u5b66\u5de5\u7a0b\u5b66\u9662\u4e3a\u8bba\u6587\u7b2c\u4e00\u5355\u4f4d\uff0c\u5434\u94a7\u6559\u6388\u4e3a\u6700\u540e\u901a\u8baf\u4f5c\u8005\u3002\u5408\u4f5c\u65b9\u5eb7\u5948\u5c14\u5927\u5b66\u7684\u9a6c\u660e\u6797\u6559\u6388\u548c\u4e2d\u56fd\u836f\u79d1\u5927\u5b66\u7684\u845b\u4eae\u526f\u6559\u6388\u4e3a\u5171\u540c\u901a\u8baf\u4f5c\u8005\u3002<\/strong><\/p>\n

\"\"<\/p>\n

\u3010\u56fe\u6587\u89e3\u8bfb\u3011<\/strong><\/p>\n

\u56fe\u4e00\u3001\u5916\u6ccc\u4f53\u5e73\u53f0\uff08Rex\uff09\u8d1f\u8f7dPt(lau)HSA NPs\u8fdb\u884c\u6709\u6548\u6cbb\u7597\u4e73\u817a\u764c\u7684\u793a\u610f\u56fe<\/strong><\/p>\n

\"\"<\/p>\n

\u56fe\u4e8c\u3001 Pt(lau)HSA NPs\u548cNPs\/Rex\u7b49\u7ec4\u7684\u7406\u5316\u8868\u5f81<\/strong>
\n \"\"\uff08A\uff09\u6709\u548c\u7269Pt(IV)\u524d\u836f\u7684\u60c5\u51b5\u4e0bHSA\u7684\u8367\u5149\u53d1\u5c04\u5149\u8c31\uff1b<\/p>\n

\uff08B\uff09Pt(lau)\u4e0eHSA\u7684\u6c28\u57fa\u9178\u6b8b\u57fa\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u6a21\u578b\uff1b<\/p>\n

\uff08C\uff09Pt(IV)HSA NPs\u88ab\u5305\u5c01\u5230Rex\u4e2d\u7684\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08D\uff09Pt(lau)HSA NPs\u7684\u5c3a\u5bf8\u548cZeta\u7535\u4f4d\u7684\u5206\u5e03\uff1b<\/p>\n

\uff08E\uff09NPs\/Rex\u7684\u5c3a\u5bf8\u548cZeta\u7535\u4f4d\u7684\u5206\u5e03\uff1b<\/p>\n

\uff08F\uff09Pt(lau)HSA NPs\u7684TEM\u56fe\u50cf\uff08\u6bd4\u4f8b\u5c3a= 100 nm\uff09\uff1b<\/p>\n

\uff08G\uff09NPs\/Rex\u7684TEM\u56fe\u50cf\uff08\u6bd4\u4f8b\u5c3a= 100 nm\uff09\uff1b<\/p>\n

\uff08H\uff09\u5f53\u88ab\u6355\u83b7\u65f6\uff0cRex\uff08\u84dd\u8272\uff09\u548cNPs Rex\uff08\u7ea2\u8272\uff09\u7528\u7279\u5f02\u4e8e\u5de8\u566c\u7ec6\u80de\u6807\u8bb0\u7684Alexa Fluor 488\u6807\u8bb0\u7684\u6297\u4f53\u67d3\u8272\u3002<\/p>\n

\u56fe\u4e09\u3001Pt(lau)HSA NPs\u548cNPs\/Rex\u7b49\u7ec4\u7684\u4f53\u5916\u7ec6\u80de\u5b9e\u9a8c<\/strong>
\n \"\"\uff08A\uff09\u7528Dil-NPs\/Rex\u4ee50.5\u548c5.0 \u03bcg\/ mL\u5b75\u80b24T1\u7ec6\u80de\u7684\u5e73\u5747\u8367\u5149\u5f3a\u5ea6\uff08MFI\uff09\uff1b<\/p>\n

\uff08B\uff09NPs\/Rex\u57284T1\u7ec6\u80de\u4e2d\u7684\u4f5c\u7528\u673a\u5236\uff1b<\/p>\n

\uff08C\uff09\u5b75\u80b26 h\u540e\u987aPt\u3001Pt(lau)HSA NPs\u548cNPs\/Rex\u57284T1\u7ec6\u80de\u4e2d\u7684\u5206\u5e03\uff1b<\/p>\n

\uff08D\uff09\u5b75\u80b26 h\u540e\u987aPt\u3001Pt(lau)HSA NPs\u548cNPs\/Rex\u57284T1\u7ec6\u80de\u4e2d\u7684DNA\u5e73\u677f\u5316\uff1b<\/p>\n

\uff08E\uff09\u7528\u987aPt\u3001Pt(lau)HSA NPs\u548cNPs\/Rex\u5904\u7406\u7ec6\u80de72 h\u540e\u7684\u7ec6\u80de\u6bd2\u6027\uff1b<\/p>\n

\uff08F\uff09\u7528\u987aPt\u3001Pt(lau)HSA NPs\u548cNPs\/Rex\u5904\u7406\u76844T1\u7ec6\u80de\u7684\u7ec6\u80de\u6d3b\u529b\u7684\u53cc\u8272\u6838\u67d3\u8272\uff1b<\/p>\n

\uff08G\uff09\u7528\u987aPt\u3001Pt(lau)HSA NPs\u548cNPs\/Rex\u4ee510 \u03bcM\u5904\u740624 h\u76844T1\u7ec6\u80de\u7684\u6d41\u5f0f\u7ec6\u80de\u56fe\uff1b<\/p>\n

\uff08H\uff09\u7528\u987aPt\u3001Pt(lau)HSA NPs\u548cNPs\/Rex\u5b75\u80b212 h\u540e 4T1\u7ec6\u80de\u7684\u7ebf\u7c92\u4f53\u819c\u7535\u4f4d\uff1b<\/p>\n

\uff08I\uff09\u7528PBS\u3001HAS\u3001Rex\u3001\u987aPt\u3001Pt(lau)HSA NPs\u548cNPs\/Rex\u5b75\u80b212 h\u540e4T1\u7ec6\u80de\u7684ROS\u6c34\u5e73\uff1b<\/p>\n

\uff08J\uff09\u7528PBS\u3001HAS\u3001Rex\u3001\u987aPt\u3001Pt(lau)HSA NPs\u548cNPs\/Rex\u5b75\u80b212 h\u76844T1\u7ec6\u80de\u7684\u534a\u80f1\u5929\u51ac\u91763\/7\u6d3b\u6027\u3002<\/p>\n

\u56fe\u56db\u3001Pt(lau)HSA NPs\u548cNPs\/Rex\u7b49\u7ec4\u7684\u5c0f\u9f20\u4f53\u5185\u5206\u5e03\u5b9e\u9a8c<\/strong>
\n \"\"\uff08A\uff09\u5411SD\u5927\u9f20\uff08n = 3\uff09\u5355\u6b21\u9759\u8109\u5185\u6ce8\u5c04\u540e\u987aPt\u3001Pt(lau)HSA NPs\u548cNPs\/Rex\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u66f2<\/p>\n

\uff08B\uff09\u5c06\u4e73\u817a\u764c\u7ec6\u80de\u539f\u4f4d\u6ce8\u5c04\u5230\u5c0f\u9f20\u4e73\u817a\u8102\u80aa\u57ab\u4e2d\u7684\u65b9\u6848\uff1b<\/p>\n

\uff08C\uff09\u5728\u643a\u5e264T1\u80bf\u7624\u7684BALB\/c\u5c0f\u9f20\uff08n = 3\uff09\u4e2dDiR\u3001DiR-Pt(lau)HSA NPs\u548cDiR-NPs\/Rex\u7684\u751f\u7269\u5206\u5e03\uff1b<\/p>\n

\uff08D\uff09\u4ece\u56feC\u91cf\u5316\u7684\u6bcf\u4e2a\u7ec4\u7ec7\u7684\u76f8\u5bf9\u8367\u5149\u4fe1\u53f7\u3002<\/p>\n

\u56fe\u4e94\u3001Pt(lau)HSA NPs\u548cNPs\/Rex\u7b49\u7ec4\u5bf9\u5c0f\u9f20\u4f53\u5185\u80bf\u7624\u7684\u6cbb\u7597\u6548\u679c<\/strong>
\n \"\"\uff08A\uff09\u5316\u7597\u671f\u95f4\u6765\u81ea4T1\u8377\u7624BALB\/c\u5c0f\u9f20\u7684\u8102\u80aa\u57ab\u4e2d\u7684\u539f\u4f4d\u80bf\u7624\u4f53\u79ef\uff08n = 5\uff09\uff1b<\/p>\n

\uff08B\uff09\u4e0ePBS\u76f8\u6bd4\uff0c\u5404\u79cd\u5236\u5242\u7684\u539f\u4f4d\u80bf\u7624\u6291\u5236\u7387\uff1b<\/p>\n

\uff08C\uff09\u5168\u8eab\u6cbb\u7597\u540e\u6765\u81ea\u643a\u5e264T1\u80bf\u7624\u7684BALB\/c\u5c0f\u9f20\u7684\u5178\u578b\u539f\u4f4d\u80bf\u7624\uff1b<\/p>\n

\uff08D, E\uff09H\uff06E\u548cTUNEL\u7528\u4e8e\u6bcf\u7ec4\u4e2d\u7684\u539f\u4f4d\u80bf\u7624\u3002<\/p>\n

\u56fe\u516d\u3001Pt(lau)HSA NPs\u548cNPs\/Rex\u7b49\u7ec4\u5bf9\u6297\u80ba\u764c\u8f6c\u79fb\u7684\u6cbb\u7597\u6548\u679c<\/strong>
\n \"\"\uff08A\uff09\u5316\u7597\u540e4T1\u8377\u7624BALB\/c\u5c0f\u9f20\u7684\u80ba\u8f6c\u79fb\u6027\u7ed3\u8282\u6570\uff08n = 5\uff09\uff1b<\/p>\n

\uff08B\uff09\u4e0ePBS\u76f8\u6bd4\uff0c\u5404\u79cd\u5236\u5242\u7684\u8f6c\u79fb\u6027\u7ed3\u8282\u6291\u5236\u7387\uff1b<\/p>\n

\uff08C\uff09\u6765\u81ea4T1\u8377\u7624BALB\/c\u5c0f\u9f20\u5168\u8eab\u6cbb\u7597\u540e\uff0c\u5177\u6709\u53ef\u89c6\u5316\u8f6c\u79fb\u6027\u7ed3\u8282\u7684\u80ba\u7ec4\u7ec7\uff08\u9ed1\u8272\u7bad\u5934\uff09\uff1b<\/p>\n

\uff08D\uff09\u6bcf\u7ec4\u80ba\u90e8\u8f6c\u79fb\u6027\u7ed3\u8282\u7684H\uff06E\u67d3\u8272\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

\u00a0 \u00a0 \u00a0 \u00a0 \u7efc\u4e0a\u6240\u8ff0\uff0c\u4f5c\u8005\u6210\u529f\u5408\u6210\u4e86\u4e00\u79cd\u65b0\u578b\u7684\u6c27\u5316\u8fd8\u539f\u53cd\u5e94\u6027Pt(IV)\u524d\u836f\uff0c\u5373Pt(lau)\uff0c\u5b83\u80fd\u591f\u901a\u8fc7\u758f\u6c34\u76f8\u4e92\u4f5c\u7528\u548c\u6c22\u952e\u7f51\u7edc\u4e0eHSA\u5bf9\u63a5\uff0c\u5f62\u6210Pt(lau)HSA NPs\u3002\u540c\u65f6\uff0c\u4e3a\u4e86\u660e\u786e\u5b9a\u4f4d\u539f\u4f4d\u80bf\u7624\u548c\u4e73\u817a\u764c\u7684\u8f6c\u79fb\u6027\u80ba\uff0c\u4f5c\u8005\u53c8\u8bbe\u8ba1\u4e86\u4e00\u79cd\u6765\u6e90\u4e8e\u5de8\u566c\u7ec6\u80de\u7684\u5916\u6ccc\u4f53Rex\u4ee5\u5c01\u88c5\u5bf9\u63a5\u7684NPs\u3002\u4f5c\u8005\u901a\u8fc7\u4e00\u7cfb\u5217\u7cfb\u7edf\u7684\u5b9e\u9a8c\u7814\u7a76\uff0c\u53d1\u73b0Pt(lau)HSA NPs\u5916\u6ccc\u4f53\u5e73\u53f0(NPs\/Rex)\u5177\u6709\u5f88\u597d\u7684\u6297\u80bf\u7624\u6548\u679c\u3002\u9996\u5148\uff0c\u5728\u8840\u6db2\u7cfb\u7edf\u4e2d\u8fd9\u79cd\u4eff\u751f\u6d82\u5c42NPs\/Rex\u7684\u5faa\u73af\u65f6\u95f4\u66f4\u957f\u3001\u751f\u7269\u5b89\u5168\u6027\u66f4\u9ad8\uff0c\u53ef\u4ee5\u4f18\u5148\u5728\u80bf\u7624\u90e8\u4f4d\u79ef\u805a\uff0c\u5c24\u5176\u662f\u5728\u539f\u4f4d\u8102\u80aa\u57ab\u548c\u8f6c\u79fb\u6027\u80ba\u4e2d\u3002\u7136\u540e\uff0c\u5feb\u901f\u9ad8\u6548\u5730\u5185\u5316\u5230\u80bf\u7624\u7ec6\u80de\u4e2d\u3002\u63a5\u7740\uff0c\u7531\u4e8ePt(lau)\u4e0e\u80de\u8d28\u8fd8\u539f\u5242\u7684\u53d1\u751f\u6c27\u5316\u8fd8\u539f\u53cd\u5e94\uff0c\u8be5\u7eb3\u7c73\u5e73\u53f0\u80fd\u591f\u5206\u89e3\u5e76\u91ca\u653e\u5176\u6d3b\u6027\u836f\u7269\u6838\u5fc3\uff0c\u4ece\u800c\u89e6\u53d1\u51cb\u4ea1\u4fe1\u53f7\uff0c\u6291\u5236\u7ec6\u80de\u589e\u6b96\uff0c\u5b8c\u6210\u4e73\u817a\u764c\u7684\u6740\u4f24\u4efb\u52a1\u3002\u7531\u4e8eRex\u5728\u80ba\u7ec4\u7ec7\u4e2d\u5177\u6709\u826f\u597d\u7684\u805a\u96c6\u80fd\u529b\uff0cNPs\/Rex\u53ef\u4ee5\u8fdb\u4e00\u6b65\u5e94\u7528\u4e8e\u975e\u5c0f\u7ec6\u80de\u80ba\u764c(NSCLC)\u7684\u6cbb\u7597\u3002\u6b64\u5916\uff0c\u6765\u6e90\u4e8e\u5de8\u566c\u7ec6\u80de\u7684\u5916\u6ccc\u4f53\u4e5f\u88ab\u8bc1\u660e\u4e0d\u7ecf\u4efb\u4f55\u4fee\u9970\u5c31\u80fd\u7a7f\u900f\u54fa\u4e73\u52a8\u7269\u8840\u8111\u5c4f\u969c\uff0c\u56e0\u6b64\u8be5\u5e73\u53f0\u5728\u6cbb\u7597\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf(CNS)\u75be\u75c5\u65b9\u9762\u4e5f\u6709\u5f88\u5927\u7684\u524d\u666f\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aPursuing Specific Chemotherapy of Orthotopic Breast Cancer with Lung Metastasis from Docking Nanoparticles Driven by Bioinspired Exosomes<\/a><\/strong>\uff08Nano Letter, 2019<\/strong>, DOI: 10.1021\/acs.nanolett.9b00824\uff09<\/p>\n

\u901a\u8baf\u4f5c\u8005\u7b80\u4ecb<\/strong><\/p>\n

\u5434\u94a7\uff0c\u7537\uff0c\u4e2d\u5c71\u5927\u5b66\u751f\u7269\u533b\u5b66\u5de5\u7a0b\u5b66\u9662\u6559\u6388\uff0c\u535a\u58eb\u751f\u5bfc\u5e08\uff0c\u7b2c\u5341\u4e00\u6279\u9752\u5e74\u5343\u4eba<\/strong>\u30022016\u5e74\u56de\u56fd\u524d\u4e8e\u7f8e\u56fd\u54c8\u4f5b\u5927\u5b66\u533b\u5b66\u9662\u53ca\u9ebb\u7701\u7406\u5de5\u5b66\u9662Robert Langer\u53caOmid Farokhzad\u5b9e\u9a8c\u5ba4\u62c5\u4efb\u535a\u58eb\u540e\u7814\u7a76\u5458\u53ca\u8bb2\u5e08\u30022016\u5e741\u6708\u8d77\u5168\u804c\u62c5\u4efb\u4e2d\u5c71\u5927\u5b66\u6559\u6388\uff0c\u7814\u7a76\u6d89\u53ca\u751f\u7269\u6750\u6599\u3001\u836f\u7269\u63a7\u91ca\u3001\u7ec4\u7ec7\u5de5\u7a0b\u53ca\u7eb3\u7c73\u533b\u5b66\u7b49\u524d\u6cbf\u5c16\u7aef\u9886\u57df\u3002\u5434\u94a7\u6559\u6388\u7ed3\u5408\u529f\u80fd\u9ad8\u5206\u5b50\u6750\u6599\u3001\u836f\u7269\u4f20\u9012\u3001\u7ec4\u7ec7\u5de5\u7a0b\u53ca\u7eb3\u7c73\u533b\u5b66\u51e0\u4e2a\u65b9\u5411\uff0c\u56f4\u7ed5\u201c\u65b0\u578b\u751f\u7269\u53ef\u964d\u89e3\u529f\u80fd\u9ad8\u5206\u5b50\u5728\u836f\u7269\u4f20\u9012\u53ca\u7ec4\u7ec7\u5de5\u7a0b\u4e2d\u7684\u5e94\u7528\u201d\u7b49\u7814\u7a76\u70ed\u70b9\uff0c\u4e3b\u8981\u81f4\u529b\u4e8e\uff1a1\uff09\u5f00\u53d1\u7528\u4e8e\u764c\u75c7\u6cbb\u7597\u7684\u65b0\u578b\u751f\u7269\u5b89\u5168\u7684\u7eb3\u7c73\u7f13\u63a7\u91ca\u836f\u7269\u4f53\u7cfb\uff1b2\uff09\u7814\u5236\u7528\u4e8e\u7cd6\u5c3f\u75c5\u6216\u764c\u75c7\u6cbb\u7597\u7684\u65b0\u578b\u53e3\u670d\u86cb\u767d\u7c7b\u7eb3\u7c73\u9012\u836f\u4f53\u7cfb\uff1b3\uff09\u53d1\u5c55\u65b0\u578b\u751f\u7269\u76f8\u5bb9\u6027\u9ad8\u3001\u6027\u80fd\u53ef\u8c03\u63a7\u7684\u6c34\u51dd\u80f6\u53ca\u7eb3\u7c73\u7ea4\u7ef4\u652f\u67b6\u6750\u6599\u7528\u4e8e\u4f24\u53e3\u6108\u5408\uff0c\u9aa8\u4fee\u590d\u53ca\u518d\u751f\uff0c\u5e72\u7ec6\u80de\u8c03\u63a7\u5206\u5316\u7b49\u7ec4\u7ec7\u5de5\u7a0b\u7814\u7a76\u53ca\u900f\u76ae\u836f\u7269\u9012\u9001\u7814\u7a76\uff0c<\/strong>\u53d6\u5f97\u4e86\u4e00\u7cfb\u5217\u91cd\u8981\u7814\u7a76\u8fdb\u5c55\u548c\u7814\u7a76\u6210\u679c\uff0c\u5148\u540e\u5728Chem. Rev.\u3001Adv. Drug. Deliv. Rev.\u3001Angew. Chem. Int. Ed.\u3001ACS Nano\u3001Nano Letters\u3001Adv. Funct. Mater.\u3001Biomaterials\u3001J. Control. Release<\/strong>\u7b49\u56fd\u9645\u8457\u540d\u671f\u520a\u6742\u5fd7\u53d1\u8868SCI\u8bba\u6587\u7ea690\u7bc7\uff0c\u8bba\u6587\u5f15\u7528\u7ea65500\u6b21\uff0c\u7533\u8bf7\u56fd\u9645\u56fd\u5185\u4e13\u5229\u7ea610\u9879\u3002<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4ebaCQR\u7f16\u8bd1\u3002<\/p>\n

\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1\uff1atougao@cailiaoren.com.<\/p>\n

\u4ee5\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1acailiaokefu.<\/p>\n","protected":false},"excerpt":{"rendered":"

\u3010\u80cc\u666f\u4ecb\u7ecd\u3011 \u00a0 \u00a0 \u00a0 \u00a0 \u4f17\u6240\u5468\u77e5\uff0c\u51b3\u5b9a\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u548c\u53cd\u5e94\u7684\u836f\u7269\u8fc7\u7a0b\uff0c\u5728\u836f\u7269\u5206\u5b50\u8fdb\u5165\u4eba\u4f53\u5185\u540e\u5c31\u663e\u5f97\u975e\u5e38\u91cd\u8981\u3002\u8fd9\u79cd\u76f8\u4e92\u4f5c\u7528\u5305\u62ec\u836f\u7269\u4e0e\u751f\u7269\u9776\u6807\u7684\u7ed3\u5408\u3001\u836f\u7269\u4e0e\u8840…<\/p>\n","protected":false},"author":7770,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215,2],"tags":[4004],"class_list":["post-173683","post","type-post","status-publish","format-standard","hentry","category-jiedu","category-keji","tag-nps-rex"],"_links":{"self":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/173683"}],"collection":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/users\/7770"}],"replies":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=173683"}],"version-history":[{"count":6,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/173683\/revisions"}],"predecessor-version":[{"id":174624,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/173683\/revisions\/174624"}],"wp:attachment":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=173683"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=173683"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=173683"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}