{"id":178000,"date":"2019-06-19T06:30:46","date_gmt":"2019-06-18T22:30:46","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=178000"},"modified":"2019-06-18T19:26:26","modified_gmt":"2019-06-18T11:26:26","slug":"%e5%b7%b2%e6%a0%a1%e7%a8%bf%e4%bb%b6-%e8%8b%8f%e5%b7%9e%e5%a4%a7%e5%ad%a6nano-lett-%e6%8a%a5%e9%81%93-%e9%93%81%e7%ba%b3%e7%b1%b3%e7%b2%92%e5%ad%90%e7%94%a8%e4%ba%8e%e4%bd%8e%e5%8a%9f%e7%8e%87","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=178000","title":{"rendered":"\u82cf\u5dde\u5927\u5b66Nano Lett.\u62a5\u9053: \u94c1\u7eb3\u7c73\u7c92\u5b50\u7528\u4e8e\u4f4e\u529f\u7387\u5c40\u90e8\u78c1\u70ed\u6cbb\u7597\u7ed3\u5408\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u5b9e\u73b0\u5168\u8eab\u6297\u80bf\u7624\u6cbb\u7597"},"content":{"rendered":"<p><strong>\u3010\u80cc\u666f\u4ecb\u7ecd\u3011<\/strong><\/p>\n<p>\u78c1\u70ed\u7597\u6cd5\uff08MHT\uff09\u662f\u4e00\u79cd\u5229\u7528\u78c1\u6027\u7eb3\u7c73\u7c92\u5b50\u5728\u5f3a\u4ea4\u53d8\u78c1\u573a\uff08AMF\uff09\u4e0b\u4ea7\u751f\u5927\u91cf\u70ed\u91cf\u6740\u6b7b\u80bf\u7624\u7684\u6280\u672f\u3002\u5bf9\u6bd4\u5149\u70ed\u7597\u6cd5\uff0c\u7531\u4e8eAMF\u5177\u6709\u4f18\u5f02\u7684\u7ec4\u7ec7\u7a7f\u900f\u80fd\u529b\uff0c\u6240\u4ee5MHT\u53ef\u4ee5\u6740\u6b7b\u5404\u79cd\u5668\u5b98\u4e2d\u7684\u6df1\u90e8\u80bf\u7624\u3002\u867d\u7136MHT\u4f5c\u4e3a\u5c40\u90e8\u6cbb\u7597\u5b9e\u4f53\u7624\u7684\u5fae\u521b\u65b9\u6cd5\u5728\u4e34\u5e8a\u4e0a\u8fdb\u884c\u4e86\u6d4b\u8bd5\uff0c\u4f46\u662f\u76ee\u524d\u7684MHT\u8fd8\u5b58\u5728\u8bb8\u591a\u5c40\u9650\u6027\u3002\u6b64\u5916\uff0cMHT\u6cbb\u7597\u96be\u4ee5\u6740\u6b7b\u7684\u8f6c\u79fb\u6027\u80bf\u7624\u3002\u867d\u7136\u7eaf\u94c1\u7eb3\u7c73\u9897\u7c92\uff08FeNPs\uff09\u53ef\u80fd\u662f\u6709\u6548\u7684MHT\u8bd5\u5242\uff0c\u4f46\u662f\u94c1\u5bb9\u6613\u5728\u6c34\u6eb6\u6db2\u4e2d\u88ab\u6c27\u5316\u3002\u5c3d\u7ba1\u5df2\u6709\u5f88\u591a\u62a5\u9053\u4e3a\u5229\u7528\u65e0\u673a\u7684\u58f3\u6d82\u8986\u94c1\u82af\u6765\u5236\u9020\u7528\u4e8e\u5404\u79cd\u751f\u7269\u533b\u5b66\u5e94\u7528\u7684\u542b\u94c1\u7684\u6838\u58f3\u7eb3\u7c73\u9897\u7c92\uff0c\u4f46\u662f\u5f88\u5c11\u62a5\u9053\u4f7f\u7528\u7eafFeNPs\u8fdb\u884c\u4f53\u5185MHT\u6d88\u878d\u80bf\u7624\u3002\u5176\u4e2d\uff0c\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\uff08ICB\uff09\u7b49\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u901a\u8fc7\u6fc0\u6d3b\u60a3\u8005\u81ea\u8eab\u7684\u514d\u75ab\u7cfb\u7edf\u6765\u6740\u6b7b\u80bf\u7624\u7ec6\u80de\u3002\u7136\u800c\uff0c\u5c1a\u672a\u62a5\u9053MHT\u7597\u6cd5\u4e0eICB\u514d\u75ab\u7597\u6cd5\u7684\u7ec4\u5408\u3002<\/p>\n<p><strong>\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n<p>\u6700\u8fd1\uff0c<strong>\u82cf\u5dde\u5927\u5b66\u7684\u5218\u5e84\u6559\u6388\uff08\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u8bfe\u9898\u7ec4\u62a5\u9053\u4e86\u4e00\u79cd\u901a\u8fc7\u5316\u5b66\u8fd8\u539f\u65b9\u6cd5\u5236\u5907\u7eaf\u94c1\u7eb3\u7c73\u9897\u7c92\uff08FeNPs\uff09\uff0c\u5229\u7528\u805a\u4e59\u4e8c\u9187\uff08PEG\uff09\/\u591a\u5df4\u80fa\uff08DA\uff09\u5171\u63a5\u679d\u805a\u5408\u7269\u8fdb\u884c\u5b98\u80fd\u5316\uff0c\u5f97\u5230PEG\u5316FeNPs\u3002\u8fd9\u79cd\u751f\u7269\u76f8\u5bb9\u6027\u805a\u5408\u7269\u4fee\u9970\u7684FeNPs\u5177\u6709\u826f\u597d\u7684\u6c34\u6eb6\u6db2\u7a33\u5b9a\u6027\uff0c\u4e14\u662f\u4e00\u79cd\u9ad8\u6548\u7684MHT\u8bd5\u5242\uff0c\u5728\u4f4e\u529f\u7387AFM\u4e0b\u5c31\u80fd\u4ea7\u751f\u8db3\u591f\u7684\u70ed\u91cf\u3002\u7136\u540e\uff0c\u901a\u8fc7\u5c40\u90e8\u6216\u9759\u8109\u6ce8\u5c04FeNPs\uff0c\u5728\u5c40\u90e8\u65bd\u52a0\u80bf\u7624\u805a\u7126\u6052\u5b9a\u78c1\u573a\u7684\u5e2e\u52a9\u4e0b\uff0c\u589e\u5f3a\u8fd9\u4e9b\u7eb3\u7c73\u9897\u7c92\u5728\u80bf\u7624\u5904\u7684\u7d2f\u79ef\uff0c\u4ece\u800c\u5b9e\u73b0\u5bf9\u80bf\u7624\u7684\u6709\u6548MHT\u6d88\u878d\u3002\u4f5c\u8005\u8fdb\u4e00\u6b65\u8bc1\u660e\u57fa\u4e8eFeNPs\u7684MHT\u4e0e\u5c40\u90e8\u6ce8\u5c04\u7eb3\u7c73\u4f50\u5242\u548c\u6297\u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de\u7684\u6297\u539f-4\uff08\u6297-CTLA4\uff09\u68c0\u67e5\u70b9\u963b\u65ad\u76f8\u7ed3\u5408\uff0c\u53ef\u4ea7\u751f\u6291\u5236\u80bf\u7624\u8f6c\u79fb\u7684\u5168\u8eab\u6cbb\u7597\u53cd\u5e94\u3002\u5728\u8054\u5408\u5e94\u7528MHT\u514d\u75ab\u6cbb\u7597\u540e\uff0c\u8fd8\u53ef\u4ee5\u89c2\u5bdf\u5230\u4e00\u79cd\u5f3a\u5927\u7684\u514d\u75ab\u8bb0\u5fc6\u6548\u5e94\uff0c\u4ee5\u9632\u6b62\u80bf\u7624\u590d\u53d1\u3002\u8be5\u7814\u7a76\u4e0d\u4ec5\u53d1\u73b0PEG\u8868\u9762\u4fee\u9970\u7684FeNPs\u53ef\u4ee5\u4f5c\u4e3a\u4e00\u79cd\u9ad8\u6548\u7684MHT\u836f\u7269\uff0c\u800c\u4e14\u8fd8\u63d0\u51fa\u4e86\u5c06MHT\u4e0eICB\u514d\u75ab\u6cbb\u7597\u76f8\u7ed3\u5408\u4ee5\u5728\u5c40\u90e8MHT\u6cbb\u7597\u540e\u5b9e\u73b0\u957f\u671f\u7684\u5168\u8eab\u6cbb\u7597\u53cd\u5e94\u800c\u63d0\u51fa\u65b0\u7684\u7b56\u7565\u3002\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a<strong>\u201cIron Nanoparticles for Low-Power Local Magnetic Hyperthermia in Combination with Immune Checkpoint Blockade for Systemic Antitumor Therapy\u201d<\/strong>\u53d1\u5e03\u5728\u8457\u540d\u671f\u520a<strong>Nano Lett.<\/strong>\u4e0a\u3002<strong>\u8be5\u8bba\u6587\u7b2c\u4e00\u4f5c\u8005\u4e3a\u5218\u5e84\u6559\u6388\u8bfe\u9898\u7ec4\u535a\u58eb\u751f\u5de2\u5b87\u3002<\/strong><br \/>\n <img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-178003\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/06\/TOC-2.jpeg\" alt=\"\" width=\"600\" height=\"532\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/06\/TOC-2.jpeg 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/06\/TOC-2-300x266.jpeg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><br \/>\n <strong>\u3010\u56fe\u6587\u89e3\u8bfb\u3011<\/strong><\/p>\n<p><strong>\u56fe\u4e00\u3001PRG\u5316FeNPs\u7684\u5236\u5907\u548c\u8868\u5f81<\/strong><br \/>\n <img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-178004\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/06\/1-2.jpeg\" alt=\"\" width=\"600\" height=\"485\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/06\/1-2.jpeg 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/06\/1-2-300x243.jpeg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/>\uff08a\uff09PEG\u5316FeNPs\u7684\u5408\u6210\u548c\u8868\u9762\u4fee\u9970\u7684\u793a\u610f\u56fe\uff1b<\/p>\n<p>\uff08b\uff09PEG\u5316FeNPs\u7684TEM\u56fe\u50cf\uff1b<\/p>\n<p>\uff08c\uff09FeNPs\u548cPEG\u5316FeNPs\u5728T=300 K\u65f6\u76f8\u5e94\u7684\u78c1\u6ede\u56de\u7ebf\uff1b<\/p>\n<p>\uff08d\uff09FeNPs\u3001IONC\u3001CIONP\u548cIONP\u7684\u6e29\u5ea6\u4f9d\u8d56\u6027\u78c1\u5316\uff1b<\/p>\n<p>\uff08e\uff09\u4ee5100 kHz\u7684FeNPs\u3001IONC\u3001CIONP\u548cIONP\u6d4b\u91cf\u7684SAR\uff1b<\/p>\n<p>\uff08f, g\uff09FeNPs\u3001IONC\u3001CIONP\u548cIONP\u7684\u5b9e\u65f6\u4f53\u5185IR\u70ed\u6210\u50cf\u548c\u6e29\u5ea6\u4e0a\u5347\u66f2\u7ebf\u3002<\/p>\n<p><strong>\u56fe\u4e8c\u3001\u4f53\u5185\u78c1\u70ed\u7597\u6cd5\uff08MHT\uff09<\/strong><br \/>\n <img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-178005\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/06\/2-2.jpeg\" alt=\"\" width=\"600\" height=\"756\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/06\/2-2.jpeg 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/06\/2-2-238x300.jpeg 238w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/>\uff08a\uff09\u5c40\u90e8\u6ce8\u5c04FeNPs\u540e\u4f53\u5185MHT\u7684\u793a\u610f\u56fe\uff1b<\/p>\n<p>\uff08b\uff09\u78c1\u6d41\u4ea4\u53d8\u673a\u7684\u7167\u7247\uff1b<\/p>\n<p>\uff08c, d\uff09AMF\u4e0b\u5c0f\u9f20\u7684\u5b9e\u65f6\u4f53\u5185IR\u70ed\u6210\u50cf\uff08c\uff09\u548c\u6e29\u5ea6\u4e0a\u5347\u66f2\u7ebf\uff08d\uff09\uff1b<\/p>\n<p>\uff08e, f\uff09\u5404\u79cd\u5904\u7406\u540e\u4e0d\u540c\u7ec4\u5c0f\u9f20\u7684\u80bf\u7624\u751f\u957f\u66f2\u7ebf\uff08e\uff09\u548c\u5b58\u6d3b\u5929\u6570\uff08f\uff09\uff1b<\/p>\n<p>\uff08g\uff09\u5728\u78c1\u6027\u80bf\u7624\u9776\u5411\u7684\u5e2e\u52a9\u4e0b\uff0c\u5168\u8eab\u6ce8\u5c04\u540e\u4f53\u5185MHT\u7684\u793a\u610f\u56fe\uff1b<\/p>\n<p>\uff08h\uff09\u901a\u8fc7\u9759\u8109\u5185\u6ce8\u5c04Cy5.5\u6807\u8bb0\u7684FeNPs\u7684\u5149\u5b66\u8367\u5149\u6210\u50cf\uff1b<\/p>\n<p>\uff08i\uff09\u9759\u8109\u6ce8\u5c04\u540e\u5c0f\u9f20\u4e2dCy5.5\u6807\u8bb0\u7684FeNPs\u7684\u8840\u6db2\u5faa\u73af\u66f2\u7ebf\u56fe\uff1b<\/p>\n<p>\uff08j\uff09FeNPs\u5728\u5c0f\u9f20\u4e2d\u7684\u751f\u7269\u5206\u5e03\u7279\u5f81\uff1b<\/p>\n<p>\uff08k, l\uff09\u5c0f\u9f20\u7684\u5b9e\u65f6\u4f53\u5185IR\u70ed\u6210\u50cf\u548c\u80bf\u7624\u6e29\u5ea6\u4e0a\u5347\u66f2\u7ebf\uff1b<\/p>\n<p>\uff08m, n\uff09\u5404\u79cd\u5904\u7406\u540e\u7684\u80bf\u7624\u751f\u957f\u66f2\u7ebf\u548c\u5b58\u6d3b\u767e\u5206\u6bd4\u3002<\/p>\n<p><strong>\u56fe\u4e09\u3001\u4f53\u5185MHT\u514d\u75ab\u7597\u6cd5\u5b9e\u73b0CT26\u80bf\u7624\u6a21\u578b\u7684\u8fdc\u9694\u6548\u5e94<\/strong><br \/>\n <img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-178006\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/06\/3.jpeg\" alt=\"\" width=\"600\" height=\"759\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/06\/3.jpeg 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/06\/3-237x300.jpeg 237w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/>\uff08a\uff09MHT+CTLA4\u963b\u65ad\u4ee5\u6291\u5236\u8fdc\u5904\u80bf\u7624\u751f\u957f\u7684\u793a\u610f\u56fe\uff1b<\/p>\n<p>\uff08b, c\uff09CT26\u80bf\u7624\u6a21\u578b\u5728\u5404\u79cd\u6cbb\u7597\u540e\u539f\u53d1\u6027\u548c\u8fdc\u7a0b\u7684\u80bf\u7624\u751f\u957f\u66f2\u7ebf\uff1b<\/p>\n<p>\uff08d\uff09CT26\u80bf\u7624\u6a21\u578b\u5728\u5404\u79cd\u6cbb\u7597\u540e\u4e0d\u540c\u80bf\u7624\u7ec4\u7684\u5b58\u6d3b\u767e\u5206\u6bd4\uff1b<\/p>\n<p>\uff08e\uff09\u6d41\u5f0f\u7ec6\u80de\u56fe\u663e\u793a\u590d\u53d1\u6027\u80bf\u7624\u4e2d\u4e0d\u540c\u7ec4\u7684T\u7ec6\u80de\uff1b<\/p>\n<p>\uff08f\uff09\u6d41\u5f0f\u7ec6\u80de\u56fe\u663e\u793a\u5728\u5404\u79cd\u5904\u7406\u540e\uff0c\u590d\u53d1\u6027\u80bf\u7624\u4e2dCD4+FoxP+T\u7ec6\u80de\u7684\u767e\u5206\u6bd4\uff1b<\/p>\n<p>\uff08g, h\uff09\u80bf\u7624\u5185\u80bf\u7624\u6d78\u6da6\u6027CD8+\u6740\u4f24T\u7ec6\u80de\u548cCD4 + FoxP3 +\u8c03\u63a7T\u7ec6\u80de\u7684\u6bd4\u4f8b\uff1b<\/p>\n<p>\uff08i\uff09CD8+CTL\u5728\u7b2c\u4e00\u6b21\u53bb\u9664\u80bf\u7624\u7684\u5404\u79cd\u5904\u7406\u540e\uff0c\u590d\u53d1\u6027\u80bf\u7624\u4e2d\u7684Tregs\u6bd4\u7387\uff1b<\/p>\n<p>\uff08j\uff09\u4e0d\u540c\u5904\u7406\u540e\u7b2c1\u30015\u548c9\u5929\u5206\u79bb\u7684\u5c0f\u9f20\u8840\u6e05\u4e2d\u7684\u7ec6\u80de\u56e0\u5b50\u6c34\u5e73\u3002<\/p>\n<p><strong>\u56fe\u56db\u3001\u514d\u75ab\u8bb0\u5fc6\u6548\u5e94<\/strong><br \/>\n <img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-178007\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/06\/4-2.jpeg\" alt=\"\" width=\"600\" height=\"776\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/06\/4-2.jpeg 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/06\/4-2-232x300.jpeg 232w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/>\uff08a\uff09\u8bc4\u4f30MHT\u514d\u75ab\u7597\u6cd5\u540e\u514d\u75ab\u8bb0\u5fc6\u6548\u5e94\u7684\u5b9e\u9a8c\u8bbe\u8ba1\uff1b<\/p>\n<p>\uff08b, 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href=\"https:\/\/pubs.acs.org\/doi\/full\/10.1021\/acs.nanolett.9b00579\" target=\"_blank\" rel=\"noopener\">Iron Nanoparticles for Low-Power Local Magnetic Hyperthermia in Combination with Immune Checkpoint Blockade for Systemic Antitumor Therapy<\/a><\/strong>\uff08Nano Lett., <strong>2019<\/strong>, DOI: 10.1021\/acs.nanolett.9b00579\uff09<\/p>\n<p style=\"text-align: center;\"><strong>\u901a\u8baf\u4f5c\u8005\u7b80\u4ecb<\/strong><\/p>\n<p><strong>\u5218\u5e84\u6559\u6388\u4e3a\u56fd\u5bb6\u6770\u9752\u3001\u957f\u6c5f\u5b66\u8005\u3001\u82f1\u56fd\u7687\u5bb6\u5316\u5b66\u4f1a(RSC) Fellow\u3001\u7f8e\u56fd\u533b\u5b66\u4e0e\u751f\u7269\u5de5\u7a0b\u5b66\u4f1a(AIMBE) Fellow<\/strong>\uff1b\u53d1\u8868\u5b66\u672f\u8bba\u6587280\u4f59\u7bc7\uff0c\u603bSCI\u5f15\u75284\u4e07\u4f59\u6b21\uff0cH\u56e0\u5b50106\uff1b\u4e8e2015-2018\u5e74\u8fde\u7eed\u5165\u9009\u201c\u5168\u7403\u9ad8\u88ab\u5f15\u79d1\u5b66\u5bb6\u201d\uff0c\u4efb\u751f\u7269\u6750\u6599\u9886\u57df\u56fd\u9645\u8457\u540d\u671f\u520aBiomaterials\u526f\u4e3b\u7f16\u3002<\/p>\n<p><strong>\u5728\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u9886\u57df\uff0c\u5218\u5e84\u6559\u6388\u56e2\u961f\u81ea2014\u5e74\u8d77\u57fa\u4e8e\u7eb3\u7c73\u751f\u7269\u6750\u6599\u5df2\u7ecf\u53d1\u5c55\u4e86\u4e00\u7cfb\u5217\u5149\u70ed\u6cbb\u7597\u3001\u5149\u52a8\u529b\u6cbb\u7597\u3001\u653e\u5c04\u6cbb\u7597\u7b49\u5c40\u90e8\u80bf\u7624\u7597\u6cd5\u4ecb\u5bfc\u7684\u514d\u75ab\u6cbb\u7597\u7b56\u7565\uff0c\u5176\u6838\u5fc3\u601d\u60f3\u662f\u5728\u5c40\u90e8\u6cbb\u7597\u6740\u706d\u539f\u4f4d\u80bf\u7624\u540e\u901a\u8fc7\u514d\u75ab\u523a\u6fc0\u4ea7\u751f\u201c\u80bf\u7624\u7279\u5f02\u6027\u75ab\u82d7\u201d\uff0c\u5e76\u5728\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u7597\u6cd5\u7684\u5e2e\u52a9\u4e0b\u653e\u5927\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\uff0c\u4ece\u800c\u6291\u5236\u80bf\u7624\u8f6c\u79fb\u4e0e\u590d\u53d1<\/strong>\u3002\u76f8\u5173\u4ee3\u8868\u6027\u5de5\u4f5c\u5217\u4e3e\u5982\u4e0b\uff1a<\/p>\n<p>Qian Chen, Jiawen Chen, Zhijuan Yang, Jun Xu, Ligeng Xu, Chao Liang, Xiao Han and Zhuang Liu*. \u201cNanoparticle-Enhanced Radiotherapy to Trigger Robust Cancer Immunotherapy\u201d <strong>Adv. Mater<\/strong>., 31(10), e1802228 (2019)<\/p>\n<p>Yu Chao, Ligeng Xu, Chao Liang, Liangzhu Feng, Jun Xu, Ziliang Dong, Longlong Tian, Xuan Yi, Kai Yang* and Zhuang Liu*. &#8220;Combined Local Immunostimulatory Radioisotope Therapy and Systemic Immune Checkpoint Blockade Imparts Potent Antitumour Responses&#8221; <strong>Nat. Biomed. Eng.<\/strong>, 2, 611-621(2018).<\/p>\n<p>Guangbao Yang, Ligeng Xu, Yu Chao, Jun Xu, Xiaoqi Sun, Yifan Wu, Rui Peng, and Zhuang Liu*. \u201cHollow MnO2 as A Tumor-microenvironment-responsive Biodegradable Nano-platform for Combination Therapy Favoring Antitumor Immune Responses\u201d<strong> Nat. Commun.<\/strong>, 8, 902 (2017).<\/p>\n<p>Qian Chen, Ligeng Xu, ChaoLiang, Chao Wang, Rui Peng, and Zhuang Liu*. \u201cPhotothermal Therapy with Immune-adjuvant Nanoparticles Together with Checkpoint Blockade for Effective Cancer Immunotherapy\u201d <strong>Nat. Commun.<\/strong>, 7, 13193 (2016).<\/p>\n<p>Chao Wang, Ligeng Xu, Chao Liang, Jian Xiang, Rui Peng, and Zhuang Liu*. \u201cImmunological Responses Triggered by Photothermal Therapy with Carbon Nanotubes in Combination with Anti-CTLA-4 Therapy to Inhibit Cancer Metastasis\u201d <strong>Adv. Mater.<\/strong>, 26, 8154-8162 (2014).<\/p>\n<p><strong>\u8bfe\u9898\u7ec4\u7f51\u9875\uff1ahttp:\/\/nano.suda.edu.cn\/lz\/<\/strong><\/p>\n<p>\u672c\u6587\u7531CQR\u7f16\u8bd1\u3002<\/p>\n<p>\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1\uff1atougao@cailiaoren.com.<\/p>\n<p>\u6295\u7a3f\u4ee5\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1acailiaokefu.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u80cc\u666f\u4ecb\u7ecd\u3011 \u78c1\u70ed\u7597\u6cd5\uff08MHT\uff09\u662f\u4e00\u79cd\u5229\u7528\u78c1\u6027\u7eb3\u7c73\u7c92\u5b50\u5728\u5f3a\u4ea4\u53d8\u78c1\u573a\uff08AMF\uff09\u4e0b\u4ea7\u751f\u5927\u91cf\u70ed\u91cf\u6740\u6b7b\u80bf\u7624\u7684\u6280\u672f\u3002\u5bf9\u6bd4\u5149\u70ed\u7597\u6cd5\uff0c\u7531\u4e8eAMF\u5177\u6709\u4f18\u5f02\u7684\u7ec4\u7ec7\u7a7f\u900f\u80fd\u529b\uff0c\u6240\u4ee5M&#8230;<\/p>\n","protected":false},"author":7770,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215,2],"tags":[4058],"class_list":["post-178000","post","type-post","status-publish","format-standard","hentry","category-jiedu","category-keji","tag-pegfenps-mht"],"_links":{"self":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/178000"}],"collection":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/users\/7770"}],"replies":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=178000"}],"version-history":[{"count":3,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/178000\/revisions"}],"predecessor-version":[{"id":178251,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/178000\/revisions\/178251"}],"wp:attachment":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=178000"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=178000"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=178000"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}