{"id":178741,"date":"2019-06-26T06:30:21","date_gmt":"2019-06-25T22:30:21","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=178741"},"modified":"2019-06-25T22:19:11","modified_gmt":"2019-06-25T14:19:11","slug":"%e3%80%90%e5%ae%a1%e7%a8%bf%e5%b7%b2%e5%9b%9e%e5%a4%8d%e3%80%91%e6%96%b0%e5%8a%a0%e5%9d%a1%e5%8d%97%e6%b4%8b%e7%90%86%e5%b7%a5%e5%a4%a7%e5%ad%a6adv-mater-%e7%94%a8%e4%ba%8e%e7%94%9f%e7%89%a9","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=178741","title":{"rendered":"\u65b0\u52a0\u5761\u5357\u6d0b\u7406\u5de5\u5927\u5b66Adv. Mater.:\u7528\u4e8e\u751f\u7269\u533b\u5b66\u9886\u57df\u7684\u8fd1\u7ea2\u5916\u5149\u8c03\u8282\u7684\u7eb3\u7c73\u8f6c\u6362\u5668"},"content":{"rendered":"

\u3010\u5f15\u8a00<\/strong>\u3011<\/p>\n

\u751f\u547d\u7cfb\u7edf\u4e2d\u7684\u8fdc\u7a0b\u8c03\u8282\u5728\u751f\u7269\u5b66\u548c\u533b\u5b66\u4e2d\u53d1\u6325\u4e86\u91cd\u8981\u4f5c\u7528\uff0c\u56e0\u4e3a\u5b83\u6709\u52a9\u4e8e\u63ed\u793a\u751f\u547d\u7cfb\u7edf\u4e2d\u6f5c\u5728\u7684\u751f\u7406\u8fc7\u7a0b\uff0c\u5e76\u53ef\u80fd\u6f5c\u5728\u5730\u4ea7\u751f\u65b0\u7684\u6cbb\u7597\u65b9\u5f0f\u3002\u76ee\u524d\u5f88\u591a\u7814\u7a76\u5df2\u7ecf\u4f7f\u7528\u5404\u79cd\u5916\u90e8\u523a\u6fc0\uff08\u5305\u62ec\u78c1\u573a\uff0c\u8d85\u58f0\u6ce2\uff0c\u52a0\u70ed\uff0c\u7535\u573a\u548c\u673a\u68b0\u529b\uff09\u6765\u63a7\u5236\u751f\u7269\u4f53\u5728\u6307\u5b9a\u4f4d\u7f6e\u5904\u7684\u7279\u5b9a\u751f\u7269\u8fc7\u7a0b\u3002\u8fd9\u4e9b\u523a\u6fc0\u65b9\u6cd5\u5df2\u7ecf\u80fd\u591f\u8c03\u8282\u591a\u79cd\u751f\u7269\u8fdb\u7a0b\uff0c\u5305\u62ec\u57fa\u56e0\u8f6c\u67d3\uff0c\u4fe1\u53f7\u4f20\u5bfc\u9014\u5f84\uff0c\u79bb\u5b50\u901a\u9053\uff0c\u86cb\u767d\u8d28\u6d3b\u6027\uff0c\u7ec6\u80de\u529f\u80fd\uff0c\u5206\u5b50\u5206\u79bb\u548c\u7ec4\u7ec7\u518d\u751f\u3002\u7136\u800c\uff0c\u7531\u4e8e\u78c1\u70ed\u6548\u7387\u6162\uff0c\u78c1\u573a\u9700\u8981\u6570\u5341\u5230\u6570\u5343\u79d2\u624d\u80fd\u4ea7\u751f\u8db3\u591f\u7684\u5f3a\u5ea6\uff1b\u5e76\u4e14\u5728\u8bbe\u7f6e\u78c1\u6027\u8bbe\u5907\u65f6\u9700\u8981\u590d\u6742\u7684\u64cd\u4f5c\u8fc7\u7a0b\u3002\u8d85\u58f0\u5177\u6709\u8f83\u5dee\u7684\u7ec4\u7ec7\u9776\u5411\u6027\uff0c\u5e76\u4e14\u7531\u4e8e\u8840\u7ba1\u901a\u900f\u6027\u589e\u5f3a\u53ef\u80fd\u5bfc\u81f4\u8f6c\u79fb\u6027\u6269\u6563\uff1b\u52a0\u70ed\u548c\u673a\u68b0\u529b\u5728\u65f6\u95f4\u548c\u7a7a\u95f4\u4e0a\u90fd\u5f88\u96be\u63a7\u5236\uff1b\u7535\u523a\u6fc0\u662f\u4fb5\u5165\u6027\u7684\uff0c\u540c\u6837\u5177\u6709\u8f83\u5dee\u7684\u7a7a\u95f4\u9009\u62e9\u6027\u3002\u56e0\u6b64\uff0c\u8fd9\u4e9b\u5916\u90e8\u523a\u6fc0\u7684\u5c40\u9650\u6027\u90e8\u5206\u963b\u788d\u4e86\u5b83\u4eec\u7684\u751f\u7269\u533b\u5b66\u5e94\u7528\u3002<\/p>\n

\u8c03\u8282\u751f\u7269\u8fc7\u7a0b\u7684\u53e6\u4e00\u79cd\u66ff\u4ee3\u65b9\u6848\u662f\u5149\u8c03\u8282\u3002\u7531\u4e8e\u5149\u5177\u6709\u65e0\u521b\u6027\uff0c\u9ad8\u65f6\u7a7a\u5206\u8fa8\u7387\u4ee5\u53ca\u5728\u5f3a\u5ea6\u548c\u6ce2\u957f\u4e0b\u6613\u4e8e\u63a7\u5236\u7684\u4f18\u52bf\uff0c\u56e0\u6b64\u5149\u8c03\u8282\u6709\u671b\u7528\u4e8e\u4e30\u5bcc\u7684\u751f\u7269\u533b\u5b66\u5e94\u7528\u4e2d\u3002\u9664\u4e86\u53ef\u4ee5\u6740\u6b7b\u75be\u75c5\u7ec6\u80de\u7684\u5149\u70ed\u7597\u6cd5\uff08PTT\uff09\u548c\u5149\u52a8\u529b\u7597\u6cd5\uff08PDT\uff09\u4e4b\u5916\uff0c\u57fa\u4e8e\u5149\u7684\u5e94\u7528\u5305\u62ec\u79bb\u5b50\u901a\u9053\u7684\u5149\u70ed\u5f00\u653e\uff0c\u5149\u654f\u86cb\u767d\u7684\u5149\u523a\u6fc0\uff0c\u751f\u7269\u5206\u5b50\u7684\u5149\u6d3b\u5316\u63a7\u91ca\uff0c\u7ec4\u7ec7\u7684\u5149\u4ea4\u8054\u7b49\u7b49\u3002\u7136\u800c\uff0c\u5149\u8c03\u8282\u6280\u672f\u7ecf\u5e38\u9047\u5230\u67d0\u4e9b\u5371\u53ca\u5176\u6f5c\u5728\u5e94\u7528\u7684\u56f0\u5883\u3002\u8fd9\u4e3b\u8981\u662f\u7531\u4e8e\u5728\u5149\u8c03\u8282\u4e2d\u5e7f\u6cdb\u4f7f\u7528\u7d2b\u5916\u5149\uff08UV\uff09\u6216\u53ef\u89c1\u5149\uff0c\u56e0\u4e3a\u5927\u591a\u6570\u5f53\u524d\u7684\u5149\u654f\u90e8\u5206\u4ec5\u54cd\u5e94\u8fd9\u4e9b\u6ce2\u957f\u7684\u5149\u6e90\u3002\u7d2b\u5916\u7ebf\u548c\u53ef\u89c1\u5149\u7531\u4e8e\u5176\u5728\u6d3b\u7ec4\u7ec7\u4e2d\u6613\u4e8e\u5438\u6536\u548c\u6563\u5c04\uff0c\u800c\u5177\u6709\u975e\u5e38\u6d45\u7684\u7ec4\u7ec7\u7a7f\u900f\u6df1\u5ea6\u3002\u6b64\u5916\uff0c\u6bcf\u5149\u5b50\u5177\u6709\u9ad8\u80fd\u91cf\u7684UV\u5149\u5f88\u53ef\u80fd\u635f\u574f\u751f\u7269\u5206\u5b50\uff08\u4f8b\u5982\u6838\u9178\uff0c\u86cb\u767d\u8d28\u548c\u8102\u8d28\uff09\uff0c\u53ef\u80fd\u5bfc\u81f4\u5149\u6bd2\u6027\u3002\u4e3a\u4e86\u89e3\u51b3\u8fd9\u4e9b\u95ee\u9898\uff0c\u7528\u5177\u6709\u8f83\u4f4e\u7ec4\u7ec7\u5438\u6536\u3001\u8f83\u5c11\u5149\u6563\u5c04\u548c\u8f83\u6df1\u7ec4\u7ec7\u7a7f\u900f\u7684\u8fd1\u7ea2\u5916\uff08NIR\uff09\u5149\u6e90\uff08700-1000nm\uff09\u66ff\u6362UV\u548c\u53ef\u89c1\u5149\uff0c\u4ee5\u5b9e\u73b0\u5bf9\u4e0d\u540c\u751f\u7269\u8fc7\u7a0b\u7684\u5149\u8c03\u8282\u3002<\/p>\n

\u5206\u5b50\u8f6c\u6362\u5668\u5bf9\u751f\u7269\u8fc7\u7a0b\u7684\u5149\u8c03\u8282\u662f\u5fc5\u4e0d\u53ef\u5c11\u7684\uff0c\u56e0\u4e3a\u5f88\u5c11\u6709\u5185\u6e90\u751f\u7269\u5206\u5b50\u80fd\u591f\u76f4\u63a5\u54cd\u5e94NIR\u5149\u3002\u5728\u8fd9\u65b9\u9762\uff0c\u5149\u5b66\u7eb3\u7c73\u6750\u6599\u5df2\u7ecf\u663e\u793a\u51fa\u5b83\u4eec\u4f5c\u4e3a\u5148\u8fdb\u7eb3\u7c73\u6362\u80fd\u5668\u7684\u6f5c\u529b\uff0c\u5e76\u6210\u529f\u7528\u4e8e\u5c06\u5149\u8f6c\u6362\u6210\u53ef\u4ee5\u89e6\u53d1\u751f\u7269\u8fc7\u7a0b\u6216\u751f\u7269\u5206\u5b50\u6d3b\u52a8\u7684\u6f5c\u529b\u3002\u4f8b\u5982\uff0c\u4e0a\u8f6c\u6362\u7eb3\u7c73\u7c92\u5b50\uff08UCNP\uff09\u53ef\u4ee5\u5c06NIR\u5149\u8f6c\u6362\u6210\u4e0e\u5149\u654f\u90e8\u5206\u6216\u86cb\u767d\u8d28\u79bb\u5b50\u901a\u9053\u7684\u5438\u6536\u5149\u8c31\u5339\u914d\u7684UV\u548c\u53ef\u89c1\u5149\u3002\u6709\u673a\u534a\u5bfc\u4f53\u7eb3\u7c73\u9897\u7c92\uff0c\u7eb3\u7c73\u6c27\u5316\u94f1\uff0c\u78b3\u7eb3\u7c73\u7ba1\u548c\u91d1\u5c5e\u7eb3\u7c73\u9897\u7c92\u53ef\u4ee5\u8f6c\u6362NIR\u5149\u200b\u200b\u4ee5\u4ea7\u751f\u5c40\u90e8\u70ed\u91cf\uff0c\u4ece\u800c\u5141\u8bb8\u5149\u70ed\u523a\u6fc0\u5bf9\u6e29\u5ea6\u654f\u611f\u7684\u751f\u7269\u884c\u4e3a\u3002\u6b64\u5916\uff0c\u5728\u66b4\u9732\u4e8eNIR\u5149\u65f6\uff0c\u57fa\u4e8e\u5149\u654f\u5242\u7684\u7eb3\u7c73\u7ed3\u6784\u80fd\u591f\u4ea7\u751f\u6d3b\u6027\u6c27\u7269\u8d28\uff08ROS\uff09\u4ee5\u5728\u6d3b\u4f53\u4e2d\u8bf1\u5bfc\u751f\u5316\u53cd\u5e94\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb<\/strong>\u3011<\/p>\n

\u5728\u8fd9\u7bc7\u7efc\u8ff0\u4e2d\uff0c\u65b0\u52a0\u5761\u5357\u6d0b\u7406\u5de5\u5927\u5b66\u6d66\u4f83\u88d4\u6559\u6388\u8bfe\u9898\u7ec4<\/strong>\u603b\u7ed3\u4e86\u7528\u4e8e\u8fd1\u7ea2\u5916\u5149\u8c03\u8282\u7684\u5149\u5b66\u7eb3\u7c73\u8f6c\u6362\u5668\u7684\u6700\u65b0\u53d1\u5c55\uff0c\u5305\u62ec\u795e\u7ecf\u5143\u7684\u5149\u8c03\u8282\uff0c\u57fa\u56e0\u8868\u8fbe\u548c\u89c6\u89c9\u7cfb\u7edf\uff0c\u4ee5\u53ca\u5149\u5316\u5b66\u7ec4\u7ec7\u7ed3\u5408\u3002\u5728\u6587\u7ae0\u4e2d\uff0c\u4f5c\u8005\u8ba8\u8bba\u4e86\u7eb3\u7c73\u8f6c\u6362\u5668\u7684\u8bbe\u8ba1\u539f\u7406\u3001\u5149\u5b66\u6027\u8d28\u4ee5\u53ca\u4e0eNIR\u5149\u4ecb\u5bfc\u7684\u5149\u8c03\u8282\u6709\u5173\u7684\u5de5\u4f5c\u673a\u5236\uff0c\u4ee5\u53ca\u4ee3\u8868\u6027\u5b9e\u4f8b\u3002\u6700\u540e\uff0c\u7ed9\u51fa\u4e86\u4e00\u4e2a\u7b80\u77ed\u7684\u603b\u7ed3\uff0c\u5e76\u8ba8\u8bba\u4e86\u8be5\u9886\u57df\u76ee\u524d\u7684\u6311\u6218\u548c\u524d\u666f\u3002\u8be5\u6210\u679c\u4ee5\u9898\u4e3a\u201cNanotransducers for Near-Infrared Photoregulation in Biomedicine<\/strong>\u201d\u53d1\u8868\u5728Adv. Mater<\/strong>.<\/strong>\u4e0a\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

Figure 1.<\/strong>\u7528\u4e8e\u8fd1\u7ea2\u5916\u5149\u8c03\u8282\u7684\u5149\u5b66\u7eb3\u7c73\u8f6c\u6362\u5668\u7684\u6c47\u603b<\/strong><\/p>\n

\"\"<\/p>\n

(a).\u795e\u7ecf\u5143\u7684\u5149\u8c03\u8282<\/p>\n

(b).\u57fa\u56e0\u8868\u8fbe\u7684\u5149\u8c03\u8282<\/p>\n

(c).\u89c6\u89c9\u7cfb\u7edf\u7684\u5149\u8c03\u8282<\/p>\n

(d).\u5149\u5316\u5b66\u7ec4\u7ec7\u7c98\u5408<\/p>\n

Figure 2.<\/strong>\u4e0a\u8f6c\u6362\u7eb3\u7c73\u7c92\u5b50\u4f5c\u4e3a\u7eb3\u7c73\u8f6c\u6362\u5668\u7684\u5e94\u7528<\/strong><\/p>\n

\"\"<\/p>\n

(a).UCNP\u53c2\u4e0e\u7684NIR\u4e0a\u8f6c\u6362\u5149\u9057\u4f20\u5b66\u793a\u610f\u56fe<\/p>\n

(b).\u5728980nm\u6fc0\u53d1\u4e0b\uff0cUCNP\u7684\u53d1\u5c04\u5149\u8c31\u3002\u63d2\u56fe\uff1aUCNP\u7684\u4e0a\u8f6c\u6362\u53d1\u5c04\u5f3a\u5ea6\u968f980nm\u5904\u6fc0\u53d1\u5f3a\u5ea6\u7684\u53d8\u5316<\/p>\n

(c).\u7528\u4e8e\u6d4b\u91cfUCNP\u4ecb\u5bfc\u7684\u6df1\u90e8\u8111\u7ec4\u7ec7NIR\u4e0a\u8f6c\u6362\u7684\u4f53\u5185\u7ea4\u7ef4\u5149\u5ea6\u6d4b\u5b9a\u793a\u610f\u56fe<\/p>\n

(d).\u5728\u4e0d\u540c\u8ddd\u79bb\u7684980nm NIR\u6fc0\u5149\u7167\u5c04\u4e0bVTA\u4e0a\u7684\u4e0a\u8f6c\u6362\u53d1\u5c04<\/p>\n

(e).\u53d1\u84dd\u5149\u7684NaYF4<\/sub>:Yb\/Tm@SiO2<\/sub> UCNPs\u7684\u793a\u610f\u56fe<\/p>\n

(f).\u7ecf\u9ebb\u9189\u5c0f\u9f20\u7ecf\u9885NIR\u6fc0\u5149\u523a\u6fc0VTA\u7684\u4f53\u5185\u5b9e\u9a8c\u793a\u610f\u56fe<\/p>\n

(g).\u7531DAPI\u67d3\u8272\u7684\u7ec6\u80de\u5185c-Fos\u9633\u6027\u7684\u795e\u7ecf\u5143\u7684\u767e\u5206\u6bd4<\/p>\n

(h,i).\u5728\u4e0d\u540c\u6761\u4ef6\u4e0b\u54cd\u5e94\u7ecf\u9885VTA\u523a\u6fc0\u7684\u8179\u4fa7\u7eb9\u72b6\u4f53\u4e2d\u7684\u77ac\u65f6DA\u6d53\u5ea6<\/p>\n

(j).\u5728\uff08h\uff09\u548c\uff08i\uff09\u6240\u793a\u7684\u4e94\u79cd\u6761\u4ef6\u4e0b\u7ecf\u9885\u523a\u6fc0\u5f00\u59cb\u540e15\u79d2\u5185\u7684\u7d2f\u79efDA\u91ca\u653e<\/p>\n

(k).\u7eff\u8272\u53d1\u5149NaYF4<\/sub>:Yb\/Er@SiO2<\/sub> UCNPs\u7684\u793a\u610f\u56fe<\/p>\n

(l).\u5728\u56db\u79cd\u4e0d\u540c\u6761\u4ef6\u4e0b\u7ecf\u9885NIR\u6fc0\u5149\u7167\u5c04\u540e\u6d77\u9a6c\u7684\u5171\u805a\u7126\u8367\u5149\u56fe\u50cf<\/p>\n

(m).\u5728\uff081\uff09\u4e2d\u6240\u793a\u7684\u56db\u79cd\u4e0d\u540c\u6761\u4ef6\u4e0b\u7684c-Fos\u8868\u8fbe<\/p>\n

Figure 3.<\/strong> \u534a\u5bfc\u4f53\u805a\u5408\u7269\u4f5c\u4e3a\u5149\u5b66\u7eb3\u7c73\u8f6c\u6362\u6750\u6599<\/strong><\/p>\n

\"\"<\/p>\n

(a).SP1\u548cSP2\u7684\u5316\u5b66\u7ed3\u6784<\/p>\n

(b).SPN\u548cSPNbc<\/sub>\u7684\u5408\u6210\u793a\u610f\u56fe<\/p>\n

(c).SPN1\uff0cSPN2\u548cAuNRs\u7684\u5438\u6536<\/p>\n

(d).\u7528SPN1bc<\/sub>\u5904\u7406ND7\/23\u7ec6\u80de\u548cHeLa\u7ec6\u80de\u540e\u7684\u8367\u5149\u56fe\u50cf<\/p>\n

(e).SPNbc<\/sub>\u63a7\u5236\u7684\u5149\u70ed\u6fc0\u6d3b\u795e\u7ecf\u5143\u4e2dTRPV1\u79bb\u5b50\u901a\u9053\u7684\u793a\u610f\u56fe<\/p>\n

(f).\u5728808nm\u6fc0\u5149\u7167\u5c042\u79d2\u4e4b\u524d\u548c\u4e4b\u540e\u7528SPN1bc<\/sub>\u6216SPN2bc<\/sub>\u5904\u7406\u7684ND7\/23\u7ec6\u80de\u6216HeLa\u7ec6\u80de\u7684\u8367\u5149\u56fe\u50cf<\/p>\n

(g).Fluo-8\u7684\u8367\u5149\u5f3a\u5ea6\u968f\u6fc0\u5149\u7167\u5c04\u65f6\u95f4\u7684\u53d8\u5316<\/p>\n

(h).Fluo-8\u7684\u8367\u5149\u5f3a\u5ea6\u968f\u7740\u6fc0\u5149\u7167\u5c04\u5728808nm\u5904\u7684\u53d8\u5316<\/p>\n

Figure 4.NIR<\/strong>\u8bf1\u5bfc\u7684\u5149\u9057\u4f20\u7eb3\u7c73\u5e73\u53f0\uff0c\u4ee5\u5b9e\u73b0\u7ec6\u80de\u5185<\/strong>Ca2+<\/sup><\/strong>\u4f9d\u8d56\u6027\u57fa\u56e0\u8868\u8fbe\u7684\u8fdc\u7a0b\u5149\u8c03\u8282<\/strong><\/p>\n

\"\"<\/p>\n

(a).\u94fe\u9709\u6297\u751f\u7269\u7d20\u86cb\u767d\u7f00\u5408\u7684UCNP\u4e0e\u5de5\u7a0b\u5316\u7684ORAI1 Ca2+<\/sup>\u901a\u9053\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u793a\u610f\u56fe<\/p>\n

(b).\u7531NIR\u5149\u7167\u5c04\u5f15\u53d1\u7684\u4f53\u5185NFAT\u4f9d\u8d56\u6027\u8367\u5149\u7d20\u9176\u8868\u8fbe\u7684\u793a\u610f\u56fe<\/p>\n

(c).\u4e09\u53ea\u4ee3\u8868\u6027BALB\/c\u5c0f\u9f20\u7684\u751f\u7269\u6210\u50cf\uff0c\u4e00\u53ea\u690d\u5165\u4ec5\u8868\u8fbeNFAT-Luc\u7684HeLa\u7ec6\u80de\uff08\u5de6\uff09\uff0c\u53e6\u4e24\u53ea\u7528\u8868\u8fbeLOVSoc\u548cNFAT-Luc\uff08\u4e2d\u95f4\u548c\u53f3\u4fa7\uff09\u7684\u7ec6\u80de\u3002\u7528980nm\u6fc0\u5149\u5bf9\u5c0f\u9f20\u8fdb\u884cNIR\u5149\u7167\u5c04\uff08\u5de6\u548c\u53f3\uff09\u3002\u7ea2\u8272\u5706\u5708\u8868\u793a\u690d\u5165\u533a\u57df\u3002<\/p>\n

(d).\u5728Opto-CRAC DCs\u4e2dNIR\u523a\u6fc0\u7684Ca2+<\/sup>\u6d41\u5165\uff0c\u4ee5\u4fc3\u8fdb\u672a\u6210\u719f\u7684DC\u6210\u719f\u548c\u589e\u5f3a\u6297\u80bf\u7624\u514d\u75ab\u5e94\u7b54<\/p>\n

(e).\u80bf\u7624\u63a5\u79cd\u90e8\u4f4d\u88ab\u5c4f\u853d\u6216\u66b4\u9732\u4e8eNIR\u6fc0\u5149\u7167\u5c04<\/p>\n

(f).\u4e0d\u540c\u5904\u7406\u540e\u7684\u80bf\u7624\u751f\u957f\u66f2\u7ebf<\/p>\n

(g).\u6cbb\u7597\u540e\u5c0f\u9f20\u80ba\u90e8\u80bf\u7624\u8f6c\u79fb\u7684\u6570\u91cf<\/p>\n

(h).UCNP\u4ecb\u5bfc\u7684\u5149\u9057\u4f20\u7eb3\u7c73\u7cfb\u7edf\u793a\u610f\u56fe<\/p>\n

(i).\u4f7f\u7528UCNP\u5c06Fas-Cib1-EGFP\u548cCry2-mCherry FADD\u6784\u5efa\u4f53\uff081:2\u6bd4\u4f8b\uff09\u5728HeLa\u7ec6\u80de\u4e2d\u5171\u8f6c\u67d348\u5c0f\u65f6\uff1b\u5728\u5171\u805a\u7126\u663e\u5fae\u955c\u4e0b\u89c2\u5bdfCry2-mCherry-FADD\u805a\u96c6\u81f3\u8d28\u819c\u4e0aFas-Cib1-EGFP\u7684\u65f6\u95f4\u8fc7\u7a0b<\/p>\n

(j).\u5728\u75284W NIR\u6fc0\u5149\u6216\u84dd\u5149LED\u7167\u5c04\u5904\u74062\u5c0f\u65f6\u540e\uff0c\u5728\u5149\u7167\u540e48\u5c0f\u65f6\uff0c\u5149\u89e6\u53d1HeLa\u7ec6\u80de\u4e2d\u88c2\u89e3\u7684\u805a\uff08ADP-\u6838\u7cd6\uff09\u805a\u5408\u9176\uff08PARP\uff09\u7247\u6bb5\u7684\u5f62\u6210<\/p>\n

Figure 5.<\/strong>\u6811\u679d\u72b6\u534a\u5bfc\u4f53\u805a\u5408\u7269\u7528\u4e8e\u6d3b\u7ec6\u80de\u548c\u52a8\u7269\u4e2d\u57fa\u56e0\u8868\u8fbe\u7684\u8fdc\u7a0b\u5149\u8c03\u8282<\/strong><\/p>\n

\"\"<\/p>\n

(a).DSP\u7684\u5316\u5b66\u7ed3\u6784\u548c\u81ea\u7ec4\u88c5<\/p>\n

(b).\u5728808nm NIR\u6fc0\u5149\u7167\u5c04\u4e0bDSP\u4ecb\u5bfc\u7684\u57fa\u56e0\u9012\u9001\u548c\u57fa\u56e0\u8868\u8fbe\u7684\u8fdc\u7a0b\u5149\u70ed\u6fc0\u6d3b\u7684\u793a\u610f\u56fe<\/p>\n

(c).\u7528DSP\/pHSP70-EGFP\u7eb3\u7c73\u590d\u5408\u7269\u8f6c\u67d3\u540e\u7684HeLa\u7ec6\u80de\u7684\u8367\u5149\u56fe\u50cf<\/p>\n

(d).\u6d3b\u4f53\u88f8\u9f20\u4e2d\u6fc0\u5149\u7167\u5c04\u7684\u793a\u610f\u56fe<\/p>\n

(e).\u5728808nm\u5904\u5177\u6709\u548c\u6ca1\u6709\u6fc0\u5149\u7167\u5c04\u7684\u52a8\u7269\u751f\u7269\u53d1\u5149\uff08BL\uff09\u56fe\u50cf<\/p>\n

(f).\u7528\uff08\u7ea2\u8272\uff09\u548c\u4e0d\u7528\uff08\u9ed1\u8272\uff09NIR\u6fc0\u5149\u7167\u5c04\uff0cBL\u5f3a\u5ea6\u53d8\u5316\u968f\u65f6\u95f4\u7684\u53d8\u5316<\/p>\n

(g).\u7528\u4e8e\u5149\u70ed\u6fc0\u6d3bTRPV1\u4fe1\u53f7\u4f20\u5bfc\u9014\u5f84\u4ee5\u51cf\u5f31\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684CuS-\u6297TRPV1\u5f00\u5173\u793a\u610f\u56fe<\/p>\n

(h).\u7531CuS-anti-TRPV1\u52a0\u70ed\u8bf1\u53d1\u7684Ca2+<\/sup>\u6d41\u5165\u8bf1\u5bfc\u7684VSMC\u4e2dAMPK\u78f7\u9178\u5316\u548cLC3I\u548cLC3II\u8868\u8fbe\u7684Western\u5206\u6790<\/p>\n

(i).\u4e3b\u52a8\u8109\u6839\u90e8\u7684\u67d3\u8272\u56fe\u50cf<\/p>\n

Figure 6.<\/strong>\u4e0a\u8f6c\u6362\u7eb3\u7c73\u7c92\u5b50\u7528\u4e8e\u7ec6\u80de\u5206\u5316<\/strong><\/p>\n

\"\"<\/p>\n

(a).NIR-\u5149\u4ecb\u5bfc\u7684\u5bf9\u4f53\u5916\u548c\u4f53\u5185\u57fa\u4e8eUCNP\u7684\u7eb3\u7c73\u590d\u5408\u7269\u7684KGN\u548cCa2+<\/sup>\u87af\u5408\u5242\u6216Ca2+<\/sup>\u4f9b\u4f53\u7684\u7ec6\u80de\u5185\u91ca\u653e\u7684\u63a7\u5236\u3002\u6574\u5408\u7d20\u7ed3\u5408RGD\u914d\u4f53\u4e0e\u5149\u8001\u5316\u7684UCNP\u590d\u5408\uff0c\u4ee5\u5141\u8bb8\u5b83\u4eec\u901a\u8fc7NIR\u5149\u76f4\u63a5\u8c03\u8282\u7ec6\u80de\u5185Ca2+<\/sup>\uff0c\u4ece\u800c\u8c03\u8282\u5e72\u7ec6\u80de\u5206\u5316<\/p>\n

(b,c).\u690d\u5165\u540e21\u5929\u8f6f\u9aa8\u7ec6\u80de\u6807\u8bb0\u7269\uff08\u80f6\u539f\u86cb\u767dII\u548c\u805a\u96c6\u86cb\u767d\u805a\u7cd6\uff09\uff08b\uff09\u548c\u80a5\u5927\u8f6f\u9aa8\u7ec6\u80de\u6807\u8bb0\u7269\uff08RUNX2\uff09\uff08c\uff09\u7684\u514d\u75ab\u7ec4\u7ec7\u5316\u5b66\u67d3\u8272<\/p>\n

(d).\u690d\u5165\u540e\u7b2c21\u5929\u6210\u9aa8\u7ec6\u80de\u6807\u8bb0\u7269\uff08\u9aa8\u9499\u86cb\u767d\uff09\u548c\u831c\u7d20\u7ea2S\uff08ARS\uff09\u67d3\u8272\u7684\u514d\u75ab\u7ec4\u7ec7\u5316\u5b66\u67d3\u8272<\/p>\n

Figure 7.<\/strong>\u5c06\u5149\u611f\u53d7\u5668\u7ed3\u5408\u7684<\/strong>UCNP<\/strong>\uff08<\/strong>pbUCNPs<\/strong>\uff09\u6ce8\u5c04\u5230\u5c0f\u9f20\u773c\u775b\u7684\u89c6\u7f51\u819c\u4e0b<\/strong><\/p>\n

\"\"<\/p>\n

(a).\u5728980nm\u8fde\u7eed\u6ce2\uff08CW\uff09NIR\u6fc0\u5149\u7167\u5c04\u4e0bUCNP\u7684\u53d1\u5c04\u5149\u8c31<\/p>\n

(b).\u6765\u81ea\u6ce8\u5c04PBS\u7684\u5c0f\u9f20\uff08\u5de6\uff09\u548c\u6ce8\u5c04pbUCNP\u7684\u5c0f\u9f20\uff08\u53f3\uff09\u7684\u89c6\u7f51\u819c\u7684\u8367\u5149\u56fe\u50cf\u3002(c).\u6765\u81ea\u672a\u6ce8\u5c04\u7684\u5c0f\u9f20\u7684\u9971\u548c\u5149\u7535\u6d41<\/p>\n

(d).\u660e\u6697\u7bb1\u5b9e\u9a8c\u56fe<\/p>\n

(e).\u5728\u4e09\u79cd\u4e0d\u540c\u706f\u7bb1\u6761\u4ef6\u4e0b\uff0c\u6697\u7bb1\u7684\u504f\u597d\u6307\u6570<\/p>\n

(f).\u4efb\u52a11-5\u7684Y\u5f62\u6c34\u8ff7\u5bab\u884c\u4e3a\u793a\u610f\u56fe<\/p>\n

(g).\u4efb\u52a11\u7684\u523a\u6fc0<\/p>\n

(h).\u5149\u6805\u8bc6\u522b\u4efb\u52a11\u7684\u6b63\u786e\u7387<\/p>\n

(i).\u7528\u4e8e535\u548c980nm\u5149\u6805\u7684pbUCNP\u6ce8\u5c04\u7684\u5c0f\u9f20\u548c\u5bf9\u7167\u5c0f\u9f20\u7684\u89c6\u89c9\u7a7a\u95f4\u5206\u8fa8\u7387<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

\u5229\u7528\u5149\u6765\u8fdc\u7a0b\u63a7\u5236\u751f\u7269\u8fdb\u7a0b\u7684\u5149\u8c03\u8282\u63d0\u4f9b\u4e86\u4e00\u79cd\u53ef\u5728\u751f\u7269\u533b\u5b66\u4e2d\u5e7f\u6cdb\u53d1\u5c55\u7684\u65b0\u65b9\u6cd5\u3002\u7136\u800c\uff0c\u5176\u53d1\u5c55\u6f5c\u529b\u53d7\u5230\u4e0e\u5185\u6e90\u6027\u5149\u654f\u7269\u8d28\u7684\u5149\u5b66\u54cd\u5e94\u76f8\u5339\u914d\u7684\u7d2b\u5916\uff08UV\uff09\/\u53ef\u89c1\u5149\u7684\u6d45\u7ec4\u7ec7\u7a7f\u900f\u80fd\u529b\u548c\u5149\u6bd2\u6027\u7684\u9650\u5236\u3002\u56e0\u6b64\uff0c\u7814\u7a76\u4eba\u5458\u5c06\u5177\u6709\u66f4\u597d\u7ec4\u7ec7\u7a7f\u900f\u80fd\u529b\u7684\u8fd1\u7ea2\u5916\uff08NIR\uff09\u5149\u7528\u4e8e\u5149\u8c03\u8282\u3002\u7531\u4e8e\u5728NIR\u533a\u57df\u4e2d\u5b58\u5728\u5c11\u91cf\u5185\u6e90\u6027\u751f\u7269\u5206\u5b50\u5438\u6536\u6216\u53d1\u5c04\u5149\uff0c\u56e0\u6b64\u57fa\u4e8eNIR\u5149\u7684\u7eb3\u7c73\u8f6c\u6362\u5668\u5438\u5f15\u4e86\u5f88\u591a\u5173\u6ce8\u3002\u5728\u8fd9\u65b9\u9762\uff0c\u80fd\u591f\u5c06NIR\u5149\u8f6c\u6362\u6210UV\/\u53ef\u89c1\u5149\uff0c\u70ed\u6216\u81ea\u7531\u57fa\u7684\u5149\u5b66\u7eb3\u7c73\u6750\u6599\u9002\u5408\u4e8e\u5f88\u591a\u5e94\u7528\u573a\u666f\u4e2d\u3002\u5728\u8fd9\u7bc7\u7efc\u8ff0\u4e2d\u4f5c\u8005\u603b\u7ed3\u4e86\u7528\u4e8eNIR\u5149\u4ecb\u5bfc\u7684\u533b\u5b66\u5149\u8c03\u8282\u7684\u5149\u5b66\u7eb3\u7c73\u8f6c\u6362\u5668\u7684\u6700\u65b0\u53d1\u5c55\u3001\u65b0\u5174\u7684\u5e94\u7528\uff08\u5305\u62ec\u795e\u7ecf\u6d3b\u52a8\u7684\u5149\u8c03\u8282\uff0c\u57fa\u56e0\u8868\u8fbe\u548c\u89c6\u89c9\u7cfb\u7edf\uff0c\u4ee5\u53ca\u5149\u5316\u5b66\u7ec4\u7ec7\u7ed3\u5408\uff09\u4ee5\u53ca\u7eb3\u7c73\u4f20\u611f\u5668\u7684\u8bbe\u8ba1\u3002\u6b64\u5916\uff0c\u8fd8\u8ba8\u8bba\u4e86\u8be5\u9886\u57df\u76ee\u524d\u7684\u6311\u6218\u548c\u524d\u666f\u3002<\/p>\n

Nanotransducers for Near-Infrared Photoregulation in Biomedicine<\/a><\/p>\n

(Adv. Mater., 2019, DOI: 10.1002\/adma.201901607)<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u5b66\u672f\u7ec4tt\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u6574\u7406\u7f16\u8f91\u3002\u00a0<\/p>\n

\u6750\u6599\u725b\u7f51\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u662f\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c\u70b9\u6211\u52a0\u5165\u7f16\u8f91\u90e8\u5927\u5bb6\u5ead\u3002\u00a0<\/p>\n

\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1tougao@cailiaoren.com\u3002<\/p>\n

\u6295\u7a3f\u4ee5\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1acailiaokefu\uff0c\u6211\u4eec\u4f1a\u9080\u8bf7\u5404\u4f4d\u8001\u5e08\u52a0\u5165\u4e13\u5bb6\u7fa4\u3002<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

\u3010\u5f15\u8a00\u3011 \u751f\u547d\u7cfb\u7edf\u4e2d\u7684\u8fdc\u7a0b\u8c03\u8282\u5728\u751f\u7269\u5b66\u548c\u533b\u5b66\u4e2d\u53d1\u6325\u4e86\u91cd\u8981\u4f5c\u7528\uff0c\u56e0\u4e3a\u5b83\u6709\u52a9\u4e8e\u63ed\u793a\u751f\u547d\u7cfb\u7edf\u4e2d\u6f5c\u5728\u7684\u751f\u7406\u8fc7\u7a0b\uff0c\u5e76\u53ef\u80fd\u6f5c\u5728\u5730\u4ea7\u751f\u65b0\u7684\u6cbb\u7597\u65b9\u5f0f\u3002\u76ee\u524d\u5f88\u591a\u7814\u7a76\u5df2\u7ecf\u4f7f\u7528\u5404\u79cd\u5916…<\/p>\n","protected":false},"author":7336,"featured_media":178742,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[533],"tags":[75],"class_list":["post-178741","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-zongshu","tag-biomaterial"],"_links":{"self":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/178741"}],"collection":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/users\/7336"}],"replies":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=178741"}],"version-history":[{"count":3,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/178741\/revisions"}],"predecessor-version":[{"id":178920,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/178741\/revisions\/178920"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/media\/178742"}],"wp:attachment":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=178741"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=178741"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=178741"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}