{"id":179062,"date":"2019-06-30T06:30:54","date_gmt":"2019-06-29T22:30:54","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=179062"},"modified":"2019-06-29T20:01:31","modified_gmt":"2019-06-29T12:01:31","slug":"%e3%80%90%e5%ae%a1%e7%a8%bf%e5%b7%b2%e5%9b%9e%e5%a4%8d%e3%80%91%e6%96%b0%e5%8a%a0%e5%9d%a1%e5%8d%97%e6%b4%8b%e7%90%86%e5%b7%a5%e5%a4%a7%e5%ad%a6adv-mater-%e7%94%a8%e4%ba%8e%e7%94%9f%e7%89%a9-2","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=179062","title":{"rendered":"\u65b0\u52a0\u5761\u5357\u6d0b\u7406\u5de5\u5927\u5b66Adv. Mater.:\u7528\u4e8e\u751f\u7269\u533b\u5b66\u9886\u57df\u8fd1\u7ea2\u5916\u5149\u8c03\u63a7\u7684\u7eb3\u7c73\u8f6c\u6362\u5668"},"content":{"rendered":"

\u3010\u5f15\u8a00<\/strong>\u3011<\/p>\n

\u8fdc\u7a0b\u8c03\u63a7\u751f\u7269\u6d3b\u6027\u6709\u52a9\u4e8e\u63ed\u793a\u751f\u547d\u7cfb\u7edf\u4e2d\u6f5c\u5728\u7684\u751f\u7406\u8fc7\u7a0b\uff0c\u5e76\u6709\u53ef\u80fd\u7814\u53d1\u51fa\u65b0\u7684\u6cbb\u7597\u65b9\u5f0f\uff0c\u56e0\u6b64\u5b83\u5728\u751f\u7269\u5b66\u548c\u533b\u5b66\u9886\u57df\u53d1\u6325\u4e86\u91cd\u8981\u7684\u4f5c\u7528\u3002\u76ee\u524d\u5404\u79cd\u5916\u90e8\u523a\u6fc0\uff08\u5305\u62ec\u78c1\u573a\u3001\u8d85\u58f0\u6ce2\u3001\u52a0\u70ed\u3001\u7535\u573a\u548c\u673a\u68b0\u529b\uff09\u5df2\u7ecf\u88ab\u7528\u6765\u8c03\u63a7\u751f\u7269\u4f53\u4e2d\u6307\u5b9a\u90e8\u4f4d\u7684\u7279\u5b9a\u751f\u7269\u8fc7\u7a0b\u3002\u8fd9\u4e9b\u523a\u6fc0\u65b9\u6cd5\u80fd\u591f\u5b9e\u73b0\u591a\u79cd\u751f\u7269\u6d3b\u6027\u7684\u8c03\u63a7\uff0c\u5305\u62ec\u57fa\u56e0\u8f6c\u67d3\u3001\u4fe1\u53f7\u901a\u8def\u3001\u79bb\u5b50\u901a\u9053\u3001\u86cb\u767d\u8d28\u6d3b\u6027\u3001\u7ec6\u80de\u529f\u80fd\u3001\u751f\u7269\u5206\u5b50\u5206\u79bb\u548c\u7ec4\u7ec7\u518d\u751f\u3002\u7136\u800c\uff0c\u7531\u4e8e\u5177\u6709\u6162\u7684\u78c1\u70ed\u6548\u5e94\uff0c\u78c1\u573a\u9700\u8981\u6570\u5341\u5230\u6570\u5343\u79d2\u624d\u80fd\u4ea7\u751f\u8db3\u591f\u7684\u5f3a\u5ea6\uff1b\u5e76\u4e14\u5728\u8bbe\u7f6e\u78c1\u6027\u8bbe\u5907\u65f6\u9700\u8981\u590d\u6742\u7684\u64cd\u4f5c\u8fc7\u7a0b\u3002\u8d85\u58f0\u5904\u7406\u5177\u6709\u8f83\u5dee\u7684\u7ec4\u7ec7\u9776\u5411\u6027\uff0c\u800c\u4e14\u53ef\u80fd\u4f1a\u5bfc\u81f4\u6076\u6027\u7ec6\u80de\u7684\u8f6c\u79fb\u6027\u6269\u6563\u3002\u52a0\u70ed\u3001\u673a\u68b0\u529b\u548c\u7535\u523a\u6fc0\u90fd\u5f88\u96be\u5b9e\u73b0\u5728\u65f6\u95f4\u548c\u7a7a\u95f4\u4e0a\u7684\u53ef\u63a7\u5236\u6027\u3002\u56e0\u6b64\uff0c\u8fd9\u4e9b\u5916\u90e8\u523a\u6fc0\u7684\u5c40\u9650\u6027\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u9650\u5236\u4e86\u5b83\u4eec\u7684\u751f\u7269\u533b\u5b66\u5e94\u7528\u3002<\/p>\n

\u8c03\u63a7\u751f\u7269\u8fc7\u7a0b\u7684\u53e6\u4e00\u79cd\u66ff\u4ee3\u65b9\u6cd5\u662f\u5149\u8c03\u8282\u3002\u5149\u5177\u6709\u65e0\u521b\u6027\u3001\u9ad8\u65f6\u7a7a\u5206\u8fa8\u7387\u548c\u6613\u8c03\u63a7\u6027\u7b49\u4f18\u52bf\uff0c\u56e0\u6b64\u5149\u8c03\u63a7\u6709\u671b\u5e94\u7528\u4e8e\u751f\u7269\u533b\u5b66\u9886\u57df\u7684\u5404\u4e2a\u65b9\u9762\u3002\u9664\u4e86\u7528\u4e8e\u6740\u6b7b\u75c5\u53d8\u7ec6\u80de\u7684\u5149\u70ed\u7597\u6cd5\uff08PTT\uff09\u548c\u5149\u52a8\u529b\u7597\u6cd5\uff08PDT\uff09\u4e4b\u5916\uff0c\u57fa\u4e8e\u5149\u8c03\u63a7\u7684\u751f\u7269\u5e94\u7528\u8fd8\u5305\u62ec\u79bb\u5b50\u901a\u9053\u7684\u5149\u70ed\u6253\u5f00\u3001\u5149\u654f\u86cb\u767d\u7684\u5149\u523a\u6fc0\u3001\u751f\u7269\u5206\u5b50\u7684\u5149\u6d3b\u5316\u63a7\u91ca\u4ee5\u53ca\u7ec4\u7ec7\u7684\u5149\u4ea4\u8054\u7b49\u7b49\u3002\u7136\u800c\uff0c\u5149\u8c03\u63a7\u6280\u672f\u7ecf\u5e38\u9047\u5230\u4e00\u4e9b\u9650\u5236\u5176\u6f5c\u5728\u5e94\u7528\u7684\u56f0\u5883\u3002\u8fd9\u4e3b\u8981\u662f\u7531\u4e8e\u5728\u5149\u8c03\u63a7\u4e2d\u5e7f\u6cdb\u4f7f\u7528\u7d2b\u5916\u5149\uff08UV\uff09\u6216\u53ef\u89c1\u5149\uff08\u5927\u591a\u6570\u5f53\u524d\u62a5\u9053\u7684\u5149\u654f\u6210\u5206\u4ec5\u54cd\u5e94\u8fd9\u4e9b\u6ce2\u957f\u7684\u5149\u6e90\uff09\u3002\u7d2b\u5916\u5149\u548c\u53ef\u89c1\u5149\u7531\u4e8e\u5176\u5728\u6d3b\u4f53\u7ec4\u7ec7\u4e2d\u6613\u4e8e\u88ab\u5438\u6536\u548c\u6563\u5c04\uff0c\u800c\u5177\u6709\u975e\u5e38\u6d45\u7684\u7ec4\u7ec7\u7a7f\u900f\u6df1\u5ea6\u3002\u6b64\u5916\uff0c\u7d2b\u5916\u5149\u5177\u6709\u5f88\u9ad8\u7684\u80fd\u91cf\uff0c\u5f88\u53ef\u80fd\u635f\u574f\u751f\u7269\u5206\u5b50\uff08\u4f8b\u5982\u6838\u9178\uff0c\u86cb\u767d\u8d28\u548c\u8102\u8d28\uff09\uff0c\u4ece\u800c\u5bfc\u81f4\u5149\u6bd2\u6027\u3002\u4e3a\u4e86\u89e3\u51b3\u8fd9\u4e9b\u95ee\u9898\uff0c\u53ef\u4ee5\u8003\u8651\u7528\u5177\u6709\u8f83\u4f4e\u7ec4\u7ec7\u5438\u6536\u3001\u8f83\u5c11\u5149\u6563\u5c04\u548c\u8f83\u5f3a\u7ec4\u7ec7\u7a7f\u900f\u80fd\u529b\u7684\u8fd1\u7ea2\u5916\uff08NIR\uff09\u5149\u6e90\uff08700-1000nm\uff09\u66ff\u6362UV\u548c\u53ef\u89c1\u5149\uff0c\u4ee5\u5b9e\u73b0\u5bf9\u4e0d\u540c\u751f\u7269\u6d3b\u6027\u7684\u5149\u8c03\u63a7\u3002<\/p>\n

\u7531\u4e8e\u751f\u7269\u4f53\u5185\u5f88\u5c11\u6709\u5185\u6e90\u6027\u7684\u751f\u7269\u5206\u5b50\u80fd\u591f\u76f4\u63a5\u5730\u54cd\u5e94NIR\u5149\uff0c\u5206\u5b50\u8f6c\u6362\u5668\u5bf9\u4e8e\u751f\u7269\u6d3b\u6027\u7684\u5149\u8c03\u63a7\u662f\u5fc5\u4e0d\u53ef\u5c11\u7684\u3002\u5c31\u8fd9\u4e00\u70b9\u800c\u8a00\uff0c\u5177\u6709\u5149\u5b66\u6027\u8d28\u7684\u7eb3\u7c73\u6750\u6599\u5df2\u7ecf\u5c55\u73b0\u51fa\u80fd\u591f\u5c06\u5149\u8f6c\u6362\u6210\u5404\u79cd\u5f62\u5f0f\u7684\u523a\u6fc0\u56e0\u7d20\u4ece\u800c\u8c03\u63a7\u751f\u7269\u8fc7\u7a0b\u6216\u8005\u751f\u7269\u5206\u5b50\u6d3b\u6027\u7684\u6f5c\u529b\u3002\u4f8b\u5982\uff0c\u4e0a\u8f6c\u6362\u7eb3\u7c73\u9897\u7c92\uff08UCNP\uff09\u53ef\u4ee5\u5c06NIR\u5149\u8f6c\u6362\u6210\u4e0e\u5149\u654f\u6210\u5206\u6216\u86cb\u767d\u8d28\u79bb\u5b50\u901a\u9053\u7684\u5438\u6536\u5149\u8c31\u76f8\u5339\u914d\u7684UV\u548c\u53ef\u89c1\u5149\u3002\u6709\u673a\u534a\u5bfc\u4f53\u7eb3\u7c73\u9897\u7c92\u3001\u6c27\u5316\u77f3\u58a8\u70ef\u3001\u78b3\u7eb3\u7c73\u7ba1\u548c\u91d1\u5c5e\u7eb3\u7c73\u9897\u7c92\u53ef\u4ee5\u8f6c\u6362NIR\u5149\u4ee5\u4ea7\u751f\u5c40\u90e8\u70ed\u91cf\uff0c\u4ece\u800c\u5b9e\u73b0\u5149\u70ed\u523a\u6fc0\u5bf9\u6e29\u5ea6\u654f\u611f\u7684\u751f\u7269\u884c\u4e3a\u3002\u6b64\u5916\uff0c\u5728NIR\u5149\u7167\u5c04\u4e0b\uff0c\u57fa\u4e8e\u5149\u654f\u5242\u7684\u7eb3\u7c73\u9897\u7c92\u80fd\u591f\u4ea7\u751f\u6d3b\u6027\u6c27\u81ea\u7531\u57fa\uff08ROS\uff09\u4ee5\u8bf1\u53d1\u6d3b\u4f53\u4e2d\u7684\u751f\u5316\u53cd\u5e94\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb<\/strong>\u3011<\/p>\n

\u5728\u8fd9\u7bc7\u7efc\u8ff0\u4e2d\uff0c\u65b0\u52a0\u5761\u5357\u6d0b\u7406\u5de5\u5927\u5b66\u6d66\u4f83\u88d4\u6559\u6388\u8bfe\u9898\u7ec4<\/strong>\u603b\u7ed3\u4e86\u7528\u4e8e\u8fd1\u7ea2\u5916\u5149\u8c03\u63a7\u7684\u5149\u5b66\u7eb3\u7c73\u8f6c\u6362\u5668\u7684\u6700\u65b0\u7814\u7a76\u8fdb\u5c55\uff0c\u5305\u62ec\u795e\u7ecf\u5143\u3001\u57fa\u56e0\u8868\u8fbe\u548c\u89c6\u89c9\u7cfb\u7edf\u7684\u5149\u8c03\u63a7\u4ee5\u53ca\u5149\u5316\u5b66\u7ec4\u7ec7\u7c98\u5408\u3002\u5728\u6587\u7ae0\u4e2d\uff0c\u4f5c\u8005\u8ba8\u8bba\u4e86\u7eb3\u7c73\u8f6c\u6362\u5668\u7684\u8bbe\u8ba1\u539f\u7406\u3001\u5149\u5b66\u6027\u8d28\u4ee5\u53caNIR\u5149\u4ecb\u5bfc\u7684\u5149\u8c03\u63a7\u7684\u4f5c\u7528\u673a\u5236\u3002\u6700\u540e\uff0c\u8be5\u6587\u7ae0\u7ed9\u51fa\u4e86\u4e00\u4e2a\u7b80\u77ed\u7684\u603b\u7ed3\uff0c\u5e76\u8ba8\u8bba\u4e86\u8be5\u9886\u57df\u76ee\u524d\u7684\u6311\u6218\u548c\u524d\u666f\u3002\u8be5\u6210\u679c\u4ee5\u9898\u4e3a\u201cNanotransducers for Near-Infrared Photoregulation in Biomedicine<\/strong>\u201d\u53d1\u8868\u5728Adv. Mater<\/strong>.<\/strong>\u4e0a\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

Figure 1.<\/strong>\u5149\u5b66\u7eb3\u7c73\u8f6c\u6362\u5668\u7684\u8fd1\u7ea2\u5916\u5149\u8c03\u63a7\u5e94\u7528\u6c47\u603b<\/strong><\/p>\n

\"\"<\/p>\n

(a).\u795e\u7ecf\u5143\u7684\u5149\u8c03\u63a7<\/p>\n

(b).\u57fa\u56e0\u8868\u8fbe\u7684\u5149\u8c03\u63a7<\/p>\n

(c).\u89c6\u89c9\u7cfb\u7edf\u7684\u5149\u8c03\u63a7<\/p>\n

(d).\u5149\u5316\u5b66\u7ec4\u7ec7\u7c98\u5408<\/p>\n

Figure 2.<\/strong>\u795e\u7ecf\u7cfb\u7edf\u6d3b\u6027\u7684\u5149\u9057\u4f20\u8c03\u63a7<\/strong><\/p>\n

\"\"<\/p>\n

(a).UCNP\u4ecb\u5bfc\u7684NIR\u4e0a\u8f6c\u6362\u5149\u9057\u4f20\u793a\u610f\u56fe<\/p>\n

(b).\u5728980nm\u6fc0\u53d1\u4e0b\uff0cUCNP\u7684\u53d1\u5c04\u5149\u8c31\u3002\u63d2\u56fe\uff1aUCNP\u7684\u4e0a\u8f6c\u6362\u53d1\u5c04\u5f3a\u5ea6\u968f\u6fc0\u53d1\u5f3a\u5ea6\u7684\u53d8\u5316<\/p>\n

(c).\u7528\u4e8e\u6d4b\u91cfUCNP\u4ecb\u5bfc\u7684\u6df1\u90e8\u8111\u7ec4\u7ec7NIR\u4e0a\u8f6c\u6362\u7684\u4f53\u5185\u7ea4\u7ef4\u5149\u5ea6\u6d4b\u5b9a\u793a\u610f\u56fe<\/p>\n

(d).\u5728\u4e0d\u540c\u8ddd\u79bb\u7684980nm NIR\u6fc0\u5149\u7167\u5c04\u4e0bVTA\u90e8\u4f4d\u7684\u4e0a\u8f6c\u6362\u53d1\u5c04\u5149\u8c31<\/p>\n

(e).\u53d1\u84dd\u5149\u7684NaYF4<\/sub>:Yb\/Tm@SiO2<\/sub> UCNP\u7684\u793a\u610f\u56fe<\/p>\n

(f).UCNP\u4ecb\u5bfc\u7684NIR\u5149\u523a\u6fc0VTA\u7684\u5c0f\u9f20\u4f53\u5185\u5b9e\u9a8c\u793a\u610f\u56fe<\/p>\n

(g).c-Fos\u9633\u6027\u795e\u7ecf\u7ec6\u80de\u7684\u767e\u5206\u6bd4<\/p>\n

(h,i).\u5728\u4e0d\u540c\u523a\u6fc0\u6761\u4ef6\u4e0b\uff0c\u8179\u4fa7\u7eb9\u72b6\u4f53\u4e2d\u7684\u77ac\u65f6DA\u6d53\u5ea6<\/p>\n

(j).\u5728\uff08h\uff09\u548c\uff08i\uff09\u6240\u793a\u7684\u4e94\u79cd\u6761\u4ef6\u4e0b\u7ecf\u9885\u523a\u6fc0\u540e15\u79d2\u5185\u8179\u4fa7\u7eb9\u72b6\u4f53\u4e2d\u7684\u7d2f\u79efDA\u91ca\u653e\u91cf<\/p>\n

(k).\u53d1\u7eff\u5149\u7684NaYF4<\/sub>:Yb\/Er@SiO2<\/sub> UCNP\u7684\u793a\u610f\u56fe<\/p>\n

(l).\u5728\u56db\u79cd\u4e0d\u540c\u6761\u4ef6\u4e0b\u7ecf\u9885NIR\u5149\u7167\u5c04\u540e\u6d77\u9a6c\u4f53\u7684\u5171\u805a\u7126\u8367\u5149\u56fe\u50cf<\/p>\n

(m).\u5728\uff081\uff09\u6240\u793a\u7684\u56db\u79cd\u4e0d\u540c\u6761\u4ef6\u4e0bc-Fos\u7684\u8868\u8fbe<\/p>\n

Figure 3.<\/strong> \u795e\u7ecf\u7ec6\u80de\u6d3b\u6027\u7684\u5149\u70ed\u8c03\u63a7<\/strong><\/p>\n

\"\"<\/p>\n

(a).SP1\u548cSP2\u7684\u5316\u5b66\u7ed3\u6784<\/p>\n

(b).SPN\u548cSPNbc\u7684\u5408\u6210\u793a\u610f\u56fe<\/p>\n

(c).SPN1\uff0cSPN2\u548cAuNR\u7684\u5438\u6536\u56fe\u8c31<\/p>\n

(d).SPN1bc\u5904\u7406\u540eND7\/23\u7ec6\u80de\u548cHeLa\u7ec6\u80de\u7684\u8367\u5149\u56fe\u50cf<\/p>\n

(e).SPNbc\u63a7\u5236\u7684\u5149\u70ed\u6fc0\u6d3b\u795e\u7ecf\u5143\u4e2dTRPV1\u79bb\u5b50\u901a\u9053\u7684\u793a\u610f\u56fe<\/p>\n

(f).\u5728808nm\u6fc0\u5149\u7167\u5c04\u4e4b\u524d\u548c\u7167\u5c042\u79d2\u4e4b\u540e\uff0cSPN1bc\u6216SPN2bc\u5904\u7406\u540e\u7684ND7\/23\u7ec6\u80de\u6216HeLa\u7ec6\u80de\u7684\u8367\u5149\u56fe\u50cf<\/p>\n

(g).Fluo-8\u7684\u8367\u5149\u5f3a\u5ea6\u968f\u6fc0\u5149\u7167\u5c04\u65f6\u95f4\u7684\u53d8\u5316<\/p>\n

(h).Fluo-8\u7684\u8367\u5149\u5f3a\u5ea6\u968f\u7740\u6fc0\u5149\u6253\u5f00\u548c\u5173\u95ed\u7684\u53d8\u5316<\/p>\n

Figure 4.<\/strong>\u5149\u9057\u4f20\u7eb3\u7c73\u5e73\u53f0\u7528\u4ee5\u5b9e\u73b0\u7ec6\u80de\u5185<\/strong>Ca2+<\/sup><\/strong>\u4f9d\u8d56\u6027\u57fa\u56e0\u8868\u8fbe\u7684\u8fdc\u7a0b\u5149\u8c03\u63a7<\/strong><\/p>\n

\"\"<\/p>\n

(a).\u94fe\u9709\u6297\u751f\u7269\u7d20\u86cb\u767d\u4fee\u9970\u7684UCNP\u4e0e\u57fa\u56e0\u7f16\u8f91\u7684ORAI1 Ca2+<\/sup>\u901a\u9053\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u793a\u610f\u56fe<\/p>\n

(b).\u7531NIR\u5149\u7167\u5c04\u5f15\u53d1\u7684\u4f53\u5185NFAT\u4f9d\u8d56\u6027\u8367\u5149\u7d20\u9176\u8868\u8fbe\u7684\u793a\u610f\u56fe<\/p>\n

(c).\u79fb\u690d\u8868\u8fbeNFAT-Luc\u7684HeLa\u7ec6\u80de\uff08\u5de6\uff09\u3001\u8868\u8fbeLOVSoc\u548cNFAT-Luc\uff08\u4e2d\u95f4\u548c\u53f3\uff09\u7684HeLa\u7ec6\u80de\u540e\u7ecf\u8fc7980nm\u6fc0\u5149\u7167\u5c04\uff08\u5de6\u548c\u53f3\uff09\u540eBALB\/c\u5c0f\u9f20\u7684\u751f\u7269\u53d1\u5149\u6210\u50cf\u3002\u7ea2\u8272\u5706\u5708\u8868\u793a\u7ec6\u80de\u79fb\u690d\u533a\u57df<\/p>\n

(d).NIR\u523a\u6fc0\u5f15\u8d77\u7684Opto-CRAC DC\u7ec6\u80de\u4e2dCa2+<\/sup>\u5185\u6d41\u4ee5\u4fc3\u8fdb\u672a\u6210\u719f\u7684DC\u7ec6\u80de\u7684\u6210\u719f\u548c\u589e\u5f3a\u6297\u80bf\u7624\u514d\u75ab\u5e94\u7b54\u7684\u793a\u610f\u56fe<\/p>\n

(e).NIR\u6fc0\u5149\u7167\u5c04\u80bf\u7624\u63a5\u79cd\u90e8\u4f4d\u540e\u5c0f\u9f20\u7684\u56fe\u7247<\/p>\n

(f).\u4e0d\u540c\u6761\u4ef6\u5904\u7406\u540e\u80bf\u7624\u7684\u751f\u957f\u66f2\u7ebf<\/p>\n

(g).\u7ecf\u6cbb\u7597\u540e\u5c0f\u9f20\u80ba\u90e8\u8f6c\u79fb\u80bf\u7624\u7684\u6570\u91cf<\/p>\n

(h).UCNP\u4ecb\u5bfc\u7684\u5149\u9057\u4f20\u7eb3\u7c73\u7cfb\u7edf\u7684\u5e94\u7528\u793a\u610f\u56fe<\/p>\n

(i).\u4f7f\u7528UCNP\u5c06Fas-Cib1-EGFP\u548cCry2-mCherry FADD\u6784\u5efa\u4f53\uff081\uff1a2\u6bd4\u4f8b\uff09\u8f6c\u67d3\u5230HeLa\u7ec6\u80de\u4e2d48\u5c0f\u65f6\u5e76\u7ecf\u8fc7NIR\u6fc0\u5149\u7167\u5c04\u540e\uff0cCry2-mCherry-FADD\u805a\u96c6\u5230\u8d28\u819c\u4e0a\u7684Fas-Cib1-EGFP\u7684\u65f6\u95f4\u8fc7\u7a0b<\/p>\n

(j).\u7ecf4W NIR\u6fc0\u5149\u6216\u84dd\u5149LED\u7167\u5c04\u5904\u74062\u5c0f\u65f6\u540e\uff0cHeLa\u7ec6\u80de\u4e2d\u88c2\u89e3\u7684\u805a\uff08ADP-\u6838\u7cd6\uff09\u805a\u5408\u9176\uff08PARP\uff09\u7247\u6bb5\u7684\u5f62\u6210<\/p>\n

Figure 5.<\/strong>\u6d3b\u7ec6\u80de\u548c\u52a8\u7269\u4f53\u4e2d\u57fa\u56e0\u8868\u8fbe\u7684\u8fdc\u7a0b\u5149\u70ed\u8c03\u63a7<\/strong><\/p>\n

\"\"<\/p>\n

(a).DSP\u7684\u5316\u5b66\u7ed3\u6784\u548c\u81ea\u7ec4\u88c5\u793a\u610f\u56fe<\/p>\n

(b).\u5728808nm NIR\u6fc0\u5149\u7167\u5c04\u4e0bDSP\u4ecb\u5bfc\u7684\u57fa\u56e0\u9012\u9001\u548c\u57fa\u56e0\u8868\u8fbe\u7684\u8fdc\u7a0b\u5149\u70ed\u6fc0\u6d3b\u7684\u793a\u610f\u56fe<\/p>\n

(c).\u7ecf808nm NIR\u6fc0\u5149\u7167\u5c04\u524d\u540e\uff0cDSP\/pHSP70-EGFP\u7eb3\u7c73\u590d\u5408\u7269\u8f6c\u67d3\u540e\u7684HeLa\u7ec6\u80de\u7684\u8367\u5149\u56fe\u50cf<\/p>\n

(d).\u6d3b\u4f53\u88f8\u9f20\u4e2d\u6fc0\u5149\u7167\u5c04\u7684\u793a\u610f\u56fe<\/p>\n

(e).\u7ecf808nm\u6fc0\u5149\u7167\u5c04\u7ec6\u80de\u79fb\u690d\u90e8\u4f4d\u540e\u6d3b\u4f53\u5c0f\u9f20\u7684\u751f\u7269\u53d1\u5149\uff08BL\uff09\u6210\u50cf<\/p>\n

(f).\u7ecf\uff08\u7ea2\u8272\uff09\u548c\u4e0d\u7ecf\uff08\u9ed1\u8272\uff09NIR\u6fc0\u5149\u7167\u5c04\uff0cBL\u5f3a\u5ea6\u53d8\u5316\u968f\u65f6\u95f4\u7684\u53d8\u5316\u66f2\u7ebf<\/p>\n

(g).TRPV1\u6297\u4f53\u4fee\u9970\u7684CuS\u7eb3\u7c73\u9897\u7c92\u4ecb\u5bfc\u7684\u5149\u70ed\u6fc0\u6d3bTRPV1\u4fe1\u53f7\u901a\u8def\u4ee5\u51cf\u8f7b\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u793a\u610f\u56fe<\/p>\n

(h).\u7ecfTRPV1\u6297\u4f53\u4fee\u9970\u7684CuS\u7eb3\u7c73\u9897\u7c92\u901a\u8fc7\u5149\u70ed\u6548\u5e94\u5f15\u8d77\u7684Ca2+<\/sup>\u5185\u6d41\u540eVSMC\u4e2dAMPK\u78f7\u9178\u5316\u548cLC3I\u548cLC3II\u8868\u8fbe<\/p>\n

(i).\u4e3b\u52a8\u8109\u6839\u90e8\u7684\u9971\u548c\u6cb9\u7ea2O\u67d3\u8272\u56fe\u50cf<\/p>\n

Figure 6.<\/strong>\u8f6c\u57fa\u56e0\u7cfb\u7edf\u7684\u5149\u8c03\u63a7<\/strong><\/p>\n

\"\"<\/p>\n

(a).NIR\u5149\u4ecb\u5bfc\u7684\u57fa\u4e8eUCNP\u7684\u7eb3\u7c73\u590d\u5408\u7269\u7684KGN\u548cCa2+<\/sup>\u87af\u5408\u5242\u6216Ca2+<\/sup>\u4f9b\u4f53\u7684\u7ec6\u80de\u5185\u63a7\u5236\u6027\u91ca\u653e\u3002<\/p>\n

(b,c).\u76ae\u4e0b\u79fb\u690dUCNP\u7eb3\u7c73\u590d\u5408\u7269\u6807\u8bb0\u7684\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5230\u5c0f\u9f20\u4f53\u5185\u540e21\u5929\u8f6f\u9aa8\u7ec6\u80de\u6807\u8bb0\u7269\uff08\u80f6\u539f\u86cb\u767dII\u548c\u805a\u96c6\u86cb\u767d\u805a\u7cd6\uff09\uff08b\uff09\u548c\u80a5\u5927\u8f6f\u9aa8\u7ec6\u80de\u6807\u8bb0\u7269\uff08RUNX2\uff09\uff08c\uff09\u7684\u514d\u75ab\u7ec4\u7ec7\u5316\u5b66\u67d3\u8272\u56fe\u7247<\/p>\n

(d). \u76ae\u4e0b\u79fb\u690dUCNP\u7eb3\u7c73\u590d\u5408\u7269\u6807\u8bb0\u7684\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5230\u5c0f\u9f20\u4f53\u5185\u540e\u7b2c21\u5929\u6210\u9aa8\u7ec6\u80de\u6807\u8bb0\u7269\uff08\u9aa8\u9499\u86cb\u767d\uff09\u548c\u831c\u7d20\u7ea2S\uff08ARS\uff09\u67d3\u8272\u7684\u514d\u75ab\u7ec4\u7ec7\u5316\u5b66\u67d3\u8272\u56fe\u7247<\/p>\n

Figure 7. UCNP<\/strong>\u4ecb\u5bfc\u7684\u5c0f\u9f20\u773c\u775b\u89c6\u89c9\u7cfb\u7edf\u7684\u5149\u8c03\u63a7<\/strong><\/p>\n

\"\"<\/p>\n

(a).\u5728980nm NIR\u6fc0\u5149\u7167\u5c04\u4e0bUCNP\u7684\u53d1\u5c04\u5149\u8c31<\/p>\n

(b).\u6ce8\u5c04PBS\uff08\u5de6\uff09\u548c\u5149\u611f\u53d7\u5668\u4fee\u9970\u7684UCNP\uff08pbUCNP\uff09\uff08\u53f3\uff09\u540e\u5c0f\u9f20\u7684\u89c6\u7f51\u819c\u7684\u8367\u5149\u56fe\u50cf<\/p>\n

(c).\u7ecf\u4e0d\u540c\u65b9\u5f0f\u5904\u7406\u540e\u5c0f\u9f20\u7684\u89c6\u6746\u7ec6\u80de\u7684\u9971\u548c\u5149\u7535\u6d41<\/p>\n

(d).\u660e\u6697\u7bb1\u5b9e\u9a8c\u56fe\u89e3<\/p>\n

(e).\u5728\u4e09\u79cd\u4e0d\u540c\u706f\u7bb1\u6761\u4ef6\u4e0b\uff0c\u5c0f\u9f20\u7684\u6697\u7bb1\u504f\u597d\u6307\u6570<\/p>\n

(f).\u4efb\u52a11-5\u7684Y\u5f62\u6c34\u8ff7\u5bab\u884c\u4e3a\u5b9e\u9a8c\u793a\u610f\u56fe<\/p>\n

(g).\u4efb\u52a11\u7684\u523a\u6fc0\u65b9\u5f0f\u56fe\u89e3<\/p>\n

(h).\u5c0f\u9f20\u5149\u6805\u8bc6\u522b\u4efb\u52a11\u7684\u6b63\u786e\u7387<\/p>\n

(i).\u4e0d\u540c\u6761\u4ef6\u4e0bpbUCNP\u6ce8\u5c04\u540e\u5c0f\u9f20\u548c\u5bf9\u7167\u5c0f\u9f20\u7684\u89c6\u89c9\u7a7a\u95f4\u5206\u8fa8\u7387<\/p>\n

Figure 8. UCNP<\/strong>\u4ecb\u5bfc\u7684\u5149\u5316\u5b66\u7ec4\u7ec7\u7c98\u5408<\/strong><\/p>\n

\"\"<\/p>\n

(a).UCNP\/PAAm\/HA-RB\u7eb3\u7c73\u590d\u5408\u7269\u4ecb\u5bfc\u7684\u5149\u5316\u5b66\u7ec4\u7ec7\u7c98\u5408\u793a\u610f\u56fe<\/p>\n

(b).\u732a\u76ae\u7684\u5149\u5316\u5b66\u7ec4\u7ec7\u7c98\u5408\u6297\u62c9\u5f3a\u5ea6\u8bd5\u9a8c<\/p>\n

(c).\u7ecf\u4e0d\u540c\u65b9\u5f0f\u5904\u7406\u540e\u7c98\u5408\u7ec4\u7ec7\u7684\u62c9\u529b\u5f3a\u5ea6<\/p>\n

(d).\u5c0f\u9f20\u4f53\u5185\u5149\u5316\u5b66\u7ec4\u7ec7\u7c98\u5408\u5b9e\u9a8c\u793a\u610f\u56fe<\/p>\n

(e).\u7ecf\u4e0d\u540c\u65b9\u5f0f\u5904\u7406\u540e\u5c0f\u9f20\u76ae\u80a4\u7684\u56fe\u7247<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

\u5229\u7528\u5149\u6765\u8fdc\u7a0b\u8c03\u63a7\u751f\u7269\u6d3b\u6027\u7684\u5149\u8c03\u63a7\u63d0\u4f9b\u4e86\u4e00\u79cd\u53ef\u5728\u751f\u7269\u533b\u5b66\u4e2d\u5e7f\u6cdb\u5e94\u7528\u7684\u65b0\u65b9\u6cd5\u3002\u7136\u800c\uff0c\u5176\u53d1\u5c55\u6f5c\u529b\u53d7\u5230\u4e0e\u5185\u6e90\u6027\u5149\u654f\u611f\u6210\u5206\u76f8\u5339\u914d\u7684\u7d2b\u5916\uff08UV\uff09\/\u53ef\u89c1\u5149\u7684\u6d45\u7ec4\u7ec7\u7a7f\u900f\u80fd\u529b\u548c\u5149\u6bd2\u6027\u7684\u9650\u5236\u3002\u56e0\u6b64\uff0c\u7814\u7a76\u4eba\u5458\u5c06\u5177\u6709\u66f4\u597d\u7ec4\u7ec7\u7a7f\u900f\u80fd\u529b\u7684\u8fd1\u7ea2\u5916\uff08NIR\uff09\u5149\u7528\u4e8e\u5149\u8c03\u63a7\u3002\u751f\u7269\u4f53\u5185\u5b58\u5728\u5f88\u5c11\u91cf\u7684\u5185\u6e90\u6027\u751f\u7269\u5206\u5b50\u80fd\u591f\u5438\u6536\u6216\u53d1\u5c04NIR\u5149\uff0c\u56e0\u6b64\u57fa\u4e8e\u5177\u6709NIR\u5149\u5b66\u7279\u6027\u7684\u7eb3\u7c73\u8f6c\u6362\u5668\u5438\u5f15\u4e86\u5f88\u591a\u5173\u6ce8\u3002\u5728\u8fd9\u65b9\u9762\uff0c\u8fd9\u4e9b\u5149\u5b66\u7eb3\u7c73\u6750\u6599\u80fd\u591f\u5c06NIR\u5149\u8f6c\u6362\u6210UV \/\u53ef\u89c1\u5149\u3001\u70ed\u6216\u81ea\u7531\u57fa\uff0c\u4ece\u800c\u5b9e\u73b0\u4e0d\u540c\u7684\u5149\u8c03\u63a7\u5e94\u7528\u3002\u5728\u8fd9\u7bc7\u7efc\u8ff0\u4e2d\uff0c\u4f5c\u8005\u603b\u7ed3\u4e86\u7528\u4e8eNIR\u5149\u4ecb\u5bfc\u7684\u751f\u7269\u533b\u5b66\u9886\u57df\u5149\u8c03\u63a7\u7684\u5149\u5b66\u7eb3\u7c73\u8f6c\u6362\u5668\u7684\u6700\u65b0\u7814\u7a76\u8fdb\u5c55\uff08\u5305\u62ec\u795e\u7ecf\u6d3b\u6027\u3001\u57fa\u56e0\u8868\u8fbe\u548c\u89c6\u89c9\u7cfb\u7edf\u7684\u5149\u8c03\u63a7\u4ee5\u53ca\u5149\u5316\u5b66\u7ec4\u7ec7\u7c98\u5408\uff09\u3002\u6b64\u5916\uff0c\u4f5c\u8005\u8fd8\u8ba8\u8bba\u4e86\u8be5\u9886\u57df\u76ee\u524d\u7684\u6311\u6218\u548c\u524d\u666f\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1a<\/strong><\/p>\n

Nanotransducers for Near-Infrared Photoregulation in Biomedicine<\/a><\/p>\n

(Adv. Mater., 2019, DOI: 10.1002\/adma.201901607)<\/p>\n

\u00a0<\/strong><\/p>\n

\u901a\u8baf\u4f5c\u8005\u7b80\u4ecb<\/strong><\/p>\n

\u6d66\u4f83\u88d4\uff0c\u73b0\u4efb\u65b0\u52a0\u5761\u5357\u6d0b\u7406\u5de5\u5927\u5b66\u5316\u5b66\u4e0e\u751f\u7269\u533b\u5b66\u5de5\u7a0b\u5b66\u9662\u526f\u6559\u6388\uff1b2011\u5e74\u4e8e\u65b0\u52a0\u5761\u56fd\u7acb\u5927\u5b66\u83b7\u5f97\u535a\u58eb\u5b66\u4f4d\uff0c\u540c\u5e74\u4f5c\u4e3a\u535a\u58eb\u540e\u52a0\u5165\u65af\u5766\u798f\u5927\u5b66\u4ece\u4e8b\u5206\u5b50\u5f71\u50cf\u5b66\u7814\u7a76\uff0c2015\u5e746\u6708\u4ee5\u526f\u6559\u6388\u53d7\u8058\u4e8e\u5357\u6d0b\u7406\u5de5\u5927\u5b66\u3002<\/p>\n

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\u8bfe\u9898\u7ec4\u4e3b\u9875\uff1ahttp:\/\/www.ntu.edu.sg\/home\/kypu\/index.html<\/a><\/p>\n

\u00a0<\/strong><\/p>\n

\u8fd1\u671f\u4ee3\u8868\u6027\u5de5\u4f5c\uff1a<\/strong><\/p>\n

    \n
  1. Huang, J. Li, Y. Lyu, Q. Miao, K. Pu*. Molecular optical imaging probes for early diagnosis of drug-induced acute kidney injury. Nat. Mater., 2019, DOI: 10.1038\/s41563-019-0378-4.<\/li>\n
  2. Miao, C. Xie, X. Zhen, Y. Lyu, H. Duan, X. Liu, J. Jokerst, K Pu*. Molecular afterglow imaging with bright, biodegradable polymer nanoparticles. Nat. Biotechnol., 2017, 35, 1102-1110.<\/li>\n
  3. Jiang, J. Huang, X. Zhen, Z. Zeng, J. Li, C. Xie, Q. Miao, J. Chen, P. Chen, K. Pu*. A generic approach towards afterglow luminescent nanoparticles for ultrasensitive in vivo imaging. Nat. Commun., 2019, 10, 2064.<\/li>\n
  4. Cheng, Q. Miao, J. Li, J. Huang, C. Xie, K. Pu*. J. Am. Chem. Soc., 2019, 141, accepted.<\/li>\n
  5. Li, J. Huang, Y. Lyu, J. Huang, Y. Jiang, C. Xie, K. Pu*. Photoactivatable organic semiconducting pro-nanoenzymes. J. Am. Chem. Soc., 2019, 141, 4073-4079.<\/li>\n
  6. He, C. Xie, Y. Jiang, K. Pu*. An organic afterglow protheranostic nanoassembly. Adv. Mater., 2019, 31, 1902672.<\/li>\n
  7. Jiang, J. Li, Z. Zeng, C. Xie, Y. Lyu, K. Pu*. Organic photodynamic nanoinhibitor for synergistic cancer therapy. Angew. Chem., Int. Ed., 2019, 58, 8161-8165.<\/li>\n
  8. Cui, J. Huang, X. Zhen, J. Li, Y. Jiang, K. Pu*. Semiconducting polymer nano-prodrug for hypoxia-activated synergetic photodynamic cancer therapy. Angew. Chem., Int. Ed., 2019, 58, 5920-5924.<\/li>\n
  9. Lyu, D. Cui, J. Huang, W. Fan, Y. Miao, K. Pu*. Near-infrared afterglow semiconducting nano-polycomplexes for multiplex differentiation of cancer exosomes. Angew. Chem., Int. Ed., 2019, 58, 4983-4987.<\/li>\n
  10. Jiang, P. Upputuri, C. Xie, Z. Zeng, A. Sharma, X. Zhen, J. Li, J. Huang, M. Pramanik, K. Pu*. Metabolizable semiconducting polymer nanoparticles for second near-infrared photoacoustic imaging. Adv. Mater., 2019, 31, 1808166.<\/li>\n
  11. Li, K. Pu*. Development of organic semiconducting materials for deep-tissue optical imaging, phototherapy and photoactivation. Chem. Soc. Rev., 2019, 48, 38-71.<\/li>\n<\/ol>\n

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