{"id":179226,"date":"2019-07-01T06:30:43","date_gmt":"2019-06-30T22:30:43","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=179226"},"modified":"2019-06-30T23:34:05","modified_gmt":"2019-06-30T15:34:05","slug":"%e5%b7%b2%e6%a0%a1%e7%a8%bf%e4%bb%b6-%e6%9e%97%e6%96%87%e6%96%8c%e5%9b%a2%e9%98%9fchem%e6%8a%a5%e9%81%93-%e7%ba%b3%e7%b1%b3%e9%87%91%e5%b1%9e%e6%9c%89%e6%9c%ba%e9%aa%a8%e6%9e%b6%e8%b0%83%e6%8e%a7","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=179226","title":{"rendered":"\u6797\u6587\u658c\u56e2\u961fChem\u62a5\u9053: \u7eb3\u7c73\u91d1\u5c5e\u6709\u673a\u9aa8\u67b6\u8c03\u63a7\u81ea\u7531\u57fa\u7597\u6cd5\u6765\u589e\u5f3a\u764c\u75c7\u514d\u75ab\u6cbb\u7597"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n

\u4f17\u6240\u5468\u77e5\uff0c\u80bf\u7624\u53ef\u4ee5\u9003\u907f\u514d\u75ab\u76d1\u89c6\uff0c\u901a\u8fc7\u8c03\u8282\u4fe1\u53f7\u901a\u8def\u7d0a\u4e71\u3001\u52ab\u6301\u514d\u75ab\u6291\u5236\u7ec6\u80de\u548c\u7ec6\u80de\u56e0\u5b50\u3001\u8017\u7aed\u6548\u5e94\u7ec6\u80de\uff08T\u7ec6\u80de\uff09\u548c\u5206\u5b50\uff0c\u4ece\u800c\u907f\u514d\u88ab\u514d\u75ab\u7cfb\u7edf\u6d88\u9664\u3002\u963b\u65ad\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1\u86cb\u767d-1\uff08PD-1\uff09\u53ca\u5176\u4e0e\u914d\u4f53\uff08PD-L1\uff09\u7b49\u514d\u75ab\u6291\u5236\u9014\u5f84\uff0c\u53ef\u4ee5\u6062\u590d\u5168\u8eab\u6027\u6297\u80bf\u7624\u514d\u75ab\uff0c\u4f7f\u5f97\u88ab\u6279\u51c6\u7684\u51e0\u79cd\u6297PD-1\u548c\u6297PD-L1\u6297\u4f53\u4f5c\u4e3a\u6cbb\u7597\u764c\u75c7\u60a3\u8005\u7684\u6709\u6548\u65b9\u6cd5\u3002\u7136\u800c\uff0c\u5355\u72ec\u9776\u5411PD-1\u548cPD-L1\u7684CBI\u4e0d\u80fd\u5728\u975e\u514d\u75ab\u539f\u6027\u80bf\u7624\u60a3\u8005\u4e2d\u5f15\u8d77\u8db3\u591f\u7684\u53cd\u5e94\u3002\u76ee\u524d\uff0c\u5e38\u7528\u7684\u5149\u52a8\u529b\u7597\u6cd5\uff08PDT\uff09\u548c\u5316\u5b66\u52a8\u529b\u7597\u6cd5\uff08CDT\uff09\u7b49\u81ea\u7531\u57fa\u7597\u6cd5\u5229\u7528\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u4e2d\u7684\u5916\u90e8\u523a\u6fc0\u6216\u5185\u6e90\u6027\u89e6\u53d1\u4ea7\u751f\u7684\u6d3b\u6027\u81ea\u7531\u57fa\uff08ROS\uff09\u6765\u6740\u6b7b\u80bf\u7624\u7ec6\u80de\u3002\u4f46\u662fTME\u4e2d\u5b58\u5728\u7684\u8fd8\u539f\u6027\u7269\u8d28\u3001\u7f3a\u6c27\u73af\u5883\u4ee5\u53ca\u5185\u6e90\u6027H2<\/sub>O2<\/sub>\u4e0d\u8db3\uff0c\u90fd\u964d\u4f4e\u4e86ROS\u6740\u80bf\u7624\u7ec6\u80de\u7684\u6548\u679c\u3002\u56e0\u6b64\uff0c\u9700\u8981\u5f00\u53d1\u65b0\u7b56\u7565\u6765\u514b\u670d\u8fd9\u4e9b\u4e0d\u5229\u56e0\u7d20\u4ee5\u589e\u5f3a\u81ea\u7531\u57fa\u7597\u6cd5\u7684\u7597\u6548\u3002\u7814\u7a76\u53d1\u73b0\u9ad8\u8868\u8fbe\u7684\u8840\u6e05\u96cc\u4e8c\u9187\uff08E2\uff09\uff0c\u4e00\u79cd\u4e3b\u8981\u7684\u96cc\u6fc0\u7d20\uff0c\u4e0e\u764c\u75c7\u98ce\u9669\u589e\u52a0\u6709\u5173\u3002E2\u4e3b\u8981\u4e0e\u96cc\u6fc0\u7d20\u53d7\u4f53ER\u03b1\u548cER\u03b2\u7ed3\u5408\uff0c\u5176\u8868\u8fbe\u6c34\u5e73\u76f4\u63a5\u5f71\u54cd\u7ec6\u80de\u589e\u6b96\uff0c\u7ec6\u80de\u5468\u671f\u505c\u6ede\uff0c\u6700\u7ec8\u5f71\u54cd\u80bf\u7624\u53d1\u751f\u3002\u5df2\u6709\u7814\u7a76\u8bc1\u660e\u901a\u8fc7\u5728\u751f\u7269\u53ef\u5229\u7528\u7684Cu2+<\/sup>\u79bb\u5b50\u50ac\u5316\u96cc\u6fc0\u7d20\u4f1a\u4ea7\u751fROS\uff0c\u8fdb\u800c\u4e0eDNA\u5f62\u6210\u7a33\u5b9a\u7684\u52a0\u5408\u7269\u3002\u56e0\u6b64\uff0c\u5c06\u81ea\u7531\u57fa\u7597\u6cd5\u548c\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u76f8\u7ed3\u5408\uff0c\u6709\u671b\u514b\u670d\u5f7c\u6b64\u4e4b\u95f4\u7684\u7f3a\u70b9\uff0c\u4ee5\u8fbe\u5230\u66f4\u597d\u7684\u6cbb\u7597\u6548\u679c\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u7f8e\u56fd\u829d\u52a0\u54e5\u5927\u5b66\u7684\u6797\u6587\u658c\u6559\u6388\uff08\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u8bfe\u9898\u7ec4\u62a5\u9053\u4e86\u4e00\u79cd\u65b0\u578b\u7684\u7eb3\u7c73\u91d1\u5c5e\u6709\u673a\u9aa8\u67b6\uff08nMOF\uff09\u8c03\u63a7\u7684\u81ea\u7531\u57fa\u7597\u6cd5\u3002\u8be5\u7597\u6cd5\u5229\u7528Cu2+<\/sup>\u50ac\u5316E2\u8bf1\u5bfc\u7684CDT\u548c\u5149\u9a71\u52a8\u7684PDT\uff0c\u4ece\u800c\u5728\u5177\u6709\u9ad8E2\u8868\u8fbe\u7684\u5c0f\u9f20\u6a21\u578b\u4e2d\u5b9e\u73b0\u5c40\u90e8\u80bf\u7624\u63a7\u5236\u4e0e\u514d\u75ab\u6fc0\u6d3b\uff0c\u5e76\u5c06\u81ea\u7531\u57fa\u7597\u6cd5\u4e0eCBI\u7ed3\u5408\u4ee5\u534f\u540c\u6cbb\u7597\u76ae\u4e0b\u9ed1\u8272\u7d20\u7624\u3002\u57fa\u4e8eCu-TBP\u7684\u9178\u54cd\u5e94\u6027\u964d\u89e3\uff0cnMOFs\u53ef\u4ee5\u5728\u80bf\u7624\u5185\u6709\u6548\u91ca\u653eCu2+<\/sup>\u548cH4<\/sub>TBP\u3002\u5176\u4e2d\uff0cCu2+<\/sup>\u50ac\u5316E2\u4ee3\u8c22\u4ee5\u4ea7\u751fH2<\/sub>O2<\/sub>\uff0c\u8fdb\u800c\u751f\u6210\u7f9f\u57fa\u81ea\u7531\u57fa\u548c\u8d85\u6c27\u5316\u7269\u7269\u8d28\uff0c\u800cH4<\/sub>TBP\u4ecb\u5bfc\u5149\u89e6\u53d1\u7684PDT\u3002nMOFs\u8c03\u63a7\u7684CDT\u540c\u65f6\u6d88\u8017\u80bf\u7624\u5185E2\u5e76\u6291\u5236\u80bf\u7624\u751f\u957f\u3002\u7ed3\u5408\u6297PD-L1\u6297\u4f53\u4f7f\u5f97nMOFs\u8c03\u63a7\u7684\u81ea\u7531\u57fa\u6cbb\u7597\u4e0d\u4ec5\u53ef\u4ee5\u6839\u9664\u5c40\u90e8\u80bf\u7624\uff0c\u800c\u4e14\u8fd8\u53ef\u4ee5\u901a\u8fc7\u540c\u7cfbB16F10\u9ed1\u8272\u7d20\u7624\u764c\u75c7\u6a21\u578b\u4e2d\u7684\u5168\u8eab\u6297\u80bf\u7624\u514d\u75ab\u6765\u6d88\u9000\u8fdc\u5904\u80bf\u7624\u3002\u6b64\u5916\uff0c\u4f5c\u8005\u8fd8\u5bf9\u514d\u75ab\u53cd\u5e94\u8fdb\u884c\u4e86\u5206\u6790\uff0c\u4ee5\u8fdb\u4e00\u6b65\u4e86\u89e3\u53cc\u91cd\u89e6\u53d1\u7684\u57fa\u56e0\u6cbb\u7597\u4e0e\u534f\u540cCBI\u5f15\u8d77\u7684\u5c40\u90e8\u6548\u5e94\u3002\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a\u201cNanoscale Metal-Organic Framework Mediates Radical Therapy to Enhance Cancer Immunotherapy\u201d<\/strong>\u53d1\u8868\u5728\u56fd\u9645\u8457\u540d\u671f\u520aChem<\/strong>\u4e0a\u3002
\n \"\"\u672c\u6587\u4eae\u70b9\uff1a<\/strong><\/p>\n

1\u3001\u94dc\u79bb\u5b50\u50ac\u5316\u7684\u96cc\u6fc0\u7d20\u4ee3\u8c22\u9014\u5f84\u88ab\u7528\u4e8e\u5316\u5b66\u52a8\u529b\u6cbb\u7597\uff1b<\/strong><\/p>\n

2\u3001\u57fa\u4e8e\u9178\u54cd\u5e94\u7684nMOF\u91ca\u653e\u7684Cu2+<\/sup>\u548cH4<\/sub>TBP\u5206\u522b\u7528\u4e8e\u5316\u5b66\u52a8\u529b\u6cbb\u7597\u548c\u5149\u52a8\u529b\u7597\u6cd5\u751f\u6210\u4e0d\u540c\u81ea\u7531\u57fa\uff1b<\/strong><\/p>\n

3\u3001\u81ea\u7531\u57fa\u7597\u6cd5\u4e0e\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u6cd5\u534f\u540c\u4f5c\u7528\u4ee5\u6cbb\u7597\u8fdc\u5904\u80bf\u7624\u3002<\/strong><\/p>\n

\u3010\u56fe\u6587\u89e3\u8bfb\u3011<\/strong><\/p>\n

\u56fe\u4e00\u3001Cu-TBP\u7684\u8868\u5f81\u548c\u7ec6\u80de\u5185\u884c\u4e3a<\/strong>
\n \"\"\uff08A\uff09Cu2<\/sub>(COO)4<\/sub>\u7684\u4fef\u89c6\u56fe\u548c\u4fa7\u89c6\u56fe\uff1b<\/p>\n

\uff08B\uff09TBP\u6865\u8fde\u914d\u4f53\u7684\u5316\u5b66\u7ed3\u6784\uff1b<\/p>\n

\uff08C\uff09Cu-TBP\u7684\u7ed3\u6784\u663e\u793a2D\u7f51\u7edc\u7684sql\u62d3\u6251\u7ed3\u6784\uff1b<\/p>\n

\uff08D, E\uff09Cu-TBP\u7684\u900f\u5c04\u7535\u5b50\u663e\u5fae\u955c\uff08TEM\uff09\u56fe\u548c\u9ad8\u5206\u8fa8\u7387TEM\u56fe\u50cf\u53ca\u5176\u5feb\u901f\u5085\u7acb\u53f6\u53d8\u6362\uff08FFT\uff09\u56fe\uff1b<\/p>\n

\uff08F\uff09Cu-TBP\u7684\u6a21\u62df\u548c\u5b9e\u9a8c\u7c89\u672bX\u5c04\u7ebf\u884d\u5c04\uff08PXRD\uff09\u56fe\uff1b<\/p>\n

\uff08G\uff09\u52a8\u6001\u5149\u6563\u5c04\uff08DLS\uff09\u6d4b\u91cf\u6c34\u4e2dCu-TBP\u7684\u7c92\u5f84\uff1b<\/p>\n

\uff08H\uff09Cu-TBP\u548cH4<\/sub>TBP\u7684UV-vis\u5149\u8c31\uff1b<\/p>\n

\uff08I\uff09Cu-TBP\u5728\u4e0d\u540cpH\u4e0b420 nm\u6fc0\u53d1\u7684\u53d1\u5c04\u5149\u8c31\uff1b<\/p>\n

\uff08J\uff09\u901a\u8fc7\u6e38\u79bbH4<\/sub>TBP\u7684UV-vis\u5438\u6536\u5b9a\u91cf\u5206\u6790\u4e0d\u540cpH\u4e0bCu-TBP\u7684\u5206\u89e3\u60c5\u51b5\uff1b<\/p>\n

\uff08K\uff09\u76f8\u540cTBP\u6d53\u5ea6\u4e3a20 \u03bcM\u7684\u5b75\u80b21, 2, 4\u62168 h\u540e\uff0cCu-TBP\u6216H4<\/sub>TBP\u7684\u7ec6\u80de\u6444\u53d6\u7387\uff1b<\/p>\n

\uff08L\uff09\u6fc0\u5149\u5171\u805a\u7126\u76d1\u6d4bCu-TBP\u6216H4<\/sub>TBP\u7684\u65f6\u95f4\u4f9d\u8d56\u6027\u7ec6\u80de\u6444\u53d6\u7387\uff1b<\/p>\n

\uff08M\uff09\u6d41\u5f0f\u7ec6\u80de\u672f\u68c0\u6d4b\u5230\u7684\u7b49\u6548TBP\u6d53\u5ea6\u7684Cu-TBP\u6216H4<\/sub>TBP\u7684\u65f6\u95f4\u4f9d\u8d56\u6027\u7ec6\u80de\u6444\u53d6\u7387\u3002<\/p>\n

\u56fe\u4e8c\u3001\u6fc0\u7d20\u548c\u5149\u5f15\u53d1ROS\u7684\u751f\u6210<\/strong>
\n \"\"\uff08A\uff09\u6fc0\u7d20\u8bf1\u5bfc\u7684Cu\u50ac\u5316\u7684ROS\u4ea7\u751f\u8fc7\u7a0b\uff1b<\/p>\n

\uff08B\uff09\u4e94\u79cd\u4e0d\u540c\u6df7\u5408\u7269\u7684\u7ec4\u5408\u7528\u4e8e\u4ea7\u751fH2<\/sub>O2<\/sub>\u548c\u22c5OH\uff1b<\/p>\n

\uff08C\uff09\u57fa\u4e8e\u8fc7\u6c27\u5316\u6c22\u8bd5\u5242\u76d2\u7684\u8367\u5149\u6765\u5b9a\u91cf\u5728A-E\u4e2d\u4ea7\u751f\u7684H2<\/sub>O2<\/sub>\uff1b<\/p>\n

\uff08D\uff09\u5229\u7528\u9999\u8c46\u7d20\u9178\u6d4b\u5b9a\u6cd5\u5b9a\u91cf\u5728A-E\u4e2d\u4ea7\u751f\u7684\u22c5OH\uff1b<\/p>\n

\uff08E\uff09\u7531Cu2+<\/sup>\u548c4-OHE2\u4ea7\u751f\u7684O2-<\/sup>\u7684BMPO\u52a0\u5408\u7269\u7684EPR\u5149\u8c31\uff1b<\/p>\n

\uff08F\uff09\u5229\u7528\u6d41\u5f0f\u7ec6\u80de\u672f\u5b9a\u91cf\u5206\u6790\u9999\u8c46\u7d20-3-\u7fa7\u9178\u4ea7\u751f\u22c5OH\u7684\u91cf\uff1b<\/p>\n

\uff08G\uff09\u7528SOSG\u548c\u8d85\u6c27\u5316\u7269\u8bd5\u5242\u76d2\u68c0\u6d4b\u5149\u7167\u5c04\u4e0bPBS\u3001CuCl2<\/sub>\u3001H4<\/sub>TBP\u6216Cu-TBP\u5904\u7406\u7684\u7ec6\u80de\u4ea7\u751f\u76841<\/sup>O2<\/sub>\u548cO2-<\/sup>\u3002<\/p>\n

\u56fe\u4e09\u3001nMOF\u8c03\u63a7\u4ea7\u751f\u7684ROS\u7684\u4f53\u5185\u53ca\u4f53\u5916\u6297\u764c\u529f\u6548<\/strong>
\n \"\"\uff08A\uff09\u6ca1\u6709\u6216\u6709\u5149\u7167\u4e0b\uff0c\u5229\u7528PBS\u3001CuCl2<\/sub>\u3001H4<\/sub>TBP\u6216Cu-TBP\u5904\u7406\u7684B16F10\u7ec6\u80de\u7684\u5149\u5b66\u56fe\uff1b<\/p>\n

\uff08B, C\uff09\u6ca1\u6709\u6216\u6709\u5149\u7167\u4e0b\uff0cCuCl2<\/sub>\u3001H4<\/sub>TBP\u6216Cu-TBP\u5904\u7406\u7684B16F10\u7ec6\u80de\u6bd2\u6027\uff08MTS\uff09\u6d4b\u5b9a\uff1b<\/p>\n

\uff08D\uff09B16F10\u7ec6\u80de\u7684\u819c\u8054\u86cb\u767dV\/PI\u5206\u6790\uff1b<\/p>\n

\uff08E\uff09\u03b3-H2<\/sub>AX\u6d4b\u5b9a\u5728\u5149\u7167\u5c04\u4e0b\u7528PBS\u3001CuCl2<\/sub>\u3001H4<\/sub>TBP\u6216Cu-TBP\u5904\u7406\u7684B16F10\u7ec6\u80de\u4e2d\u7684DNA\u53cc\u94fe\u65ad\u88c2\uff1b<\/p>\n

\uff08F\uff09\u5149\u7167\u5c04\u65f6\u7528PBS\u3001CuCl2<\/sub>\u3001H4<\/sub>TBP\u6216Cu-TBP\u5904\u7406\u7684B16F10\u7ec6\u80de\u7684COX-2\u8868\u8fbe\uff1b<\/p>\n

\uff08G, J\uff09H4<\/sub>TBP\u6216Cu-TBP\u4e0e\u7528\u6216\u4e0d\u7528\u5149\u7167\u5bf9\u643a\u5e26B16F10\u7684C57BL\/6\u5c0f\u9f20\u548c\u643a\u5e26SKOV-3\u7684\u88f8\u9f20\u7684\u6297\u764c\u6548\u529b\uff1b<\/p>\n

\uff08H, I\uff09\u5728\u4e2d\u5904\u7406\u7684\u7b2c15\u5929\u5207\u9664\u7684B16F10\u80bf\u7624\u7684\u7167\u7247\u548c\u91cd\u91cf\uff1b<\/p>\n

\uff08K, L\uff09\u6cbb\u75978\u5929\u540e\u5bf9B16F10\u6a21\u578b\u7684\u80bf\u7624\u5185\u96cc\u4e8c\u9187\u7684\u6d4b\u5b9a\u548c\u6cbb\u75973\u5929\u540e\u7684SKOV-3\u6a21\u578b\u7684\u6d4b\u5b9a\u3002<\/p>\n

\u56fe\u56db\u3001\u514d\u75ab\u539f\u6027\u548c\u8fdc\u4f4d\u6548\u5e94<\/strong>
\n \"\"\uff08A, B\uff09\u901a\u8fc7\u6d41\u5f0f\u7ec6\u80de\u672f\u548c\u5171\u805a\u7126\u663e\u5fae\u955c\u68c0\u6d4b\u5149\u7167\u5c04\u540e\uff0c\u7528PBS\u3001CuCl2<\/sub>\u3001H4<\/sub>TBP\u6216Cu-TBP\u5904\u7406\u7684B16F10\u7ec6\u80de\u8868\u9762\u4e0a\u7684CRT\u66b4\u9732\uff1b<\/p>\n

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\u8be5\u5de5\u4f5c\u7684\u7b2c\u4e00\u4f5c\u8005\u4e3a\u829d\u52a0\u54e5\u5927\u5b66\u7684\u56db\u5e74\u7ea7\u535a\u58eb\u751f\u502a\u5f00\u5143\uff0c\u901a\u8baf\u4f5c\u8005\u4e3a\u8457\u540d\u534e\u4eba\u5316\u5b66\u5bb6\u6797\u6587\u658c\u6559\u6388\u3002<\/strong><\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aNanoscale Metal-Organic Framework Mediates Radical Therapy to Enhance Cancer Immunotherapy<\/a><\/strong>. (Chem, 2019<\/strong>, DOI: 10.1016\/j.chempr.2019.05.013)<\/p>\n

\u56e2\u961f\uff08\u901a\u8baf\u4f5c\u8005\uff09\u7b80\u4ecb<\/strong><\/p>\n

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\u6797\u6587\u658c\u6559\u6388\u6240\u9886\u5bfc\u7684\u7814\u7a76\u56e2\u961f\u662f\u56fd\u9645\u4e0a\u6700\u65e9\u8fdb\u884c\u7406\u6027\u8bbe\u8ba1\u5408\u6210\u91d1\u5c5e\uff0d\u6709\u673a\u6846\u67b6\u6750\u6599\u7684\u56e2\u961f\u4e4b\u4e00\uff0c\u4e3b\u8981\u7814\u7a76\u9886\u57df\u4e3a\u529f\u80fd\u6750\u6599\u3001\u624b\u6027\u50ac\u5316\u3001\u5149\u50ac\u5316\u3001\u7eb3\u7c73\u533b\u5b66\u53ca\u5316\u5b66\u836f\u7269\u8bbe\u8ba1\u7b49<\/strong>\u3002\u6797\u6587\u658c\u6559\u6388\u7814\u7a76\u7ec4\u57282005\u5e74\u9996\u6b21\u6210\u529f\u5f00\u53d1\u51fa\u6709\u9ad8\u624b\u6027\u9009\u62e9\u6027\u7684\u91d1\u5c5e\u6709\u673a\u6846\u67b6\u5316\u5408\u7269\u4e0d\u5bf9\u79f0\u50ac\u5316\u5242\uff0c\u540c\u65f6\u5728\u5229\u7528\u91d1\u5c5e\u6709\u673a\u6846\u5316\u5408\u7269\u53d1\u5c55\u975e\u7ebf\u6027\u5149\u5b66\u6750\u6599\u53ca\u4eba\u5de5\u5149\u5408\u4f5c\u7528\u65b9\u9762\u7684\u7814\u7a76\u8d70\u5728\u56fd\u9645\u524d\u5217\uff0c\u6240\u53d1\u5c55\u7684\u5177\u6709\u4e8c\u9636\u975e\u7ebf\u6027\u5149\u5b66\u6027\u8d28\u7684\u91d1\u5c5e\u6709\u673a\u6750\u6599\u662f\u662f\u6700\u65e9\u8fdb\u884c\u6676\u4f53\u5de5\u7a0b\u65b9\u6cd5\u63a7\u5236\u91d1\u5c5e\u6709\u673a\u5316\u5408\u7269\u7684\u5c1d\u8bd5\u4e4b\u4e00\u3002\u8fd1\u5e74\u6765\uff0c\u6797\u6587\u658c\u6559\u6388\u56e2\u961f\u521b\u9020\u6027\u5730\u5f00\u53d1\u4e86\u591a\u79cd\u57fa\u4e8e\u91d1\u5c5e\u6709\u673a\u6846\u67b6\u7eb3\u7c73\u7c92\u5b50\u7684\u751f\u7269\u53ef\u964d\u89e3\u6027\u3001\u9ad8\u836f\u7269\u8f7d\u91cf\u4ee5\u53ca\u5206\u5b50\u53ef\u8c03\u63a7\u6027\u7684\u65b0\u578b\u7eb3\u7c73\u6297\u764c\u836f\u7269\u5e76\u7387\u5148\u62a5\u5bfc\u4e86\u5c40\u90e8\u7eb3\u7c73\u836f\u7269\u9012\u9001\u7528\u4e8e\u5c40\u90e8\u514d\u75ab\u6fc0\u6d3b\u4e0e\u7cfb\u7edf\u6027\u514d\u75ab\u6cbb\u7597\u76f8\u7ed3\u5408\u7684\u764c\u75c7\u6cbb\u7597\u65b0\u601d\u8def\u3002\u4e3a\u4e86\u63a8\u52a8\u76f8\u5173\u4ea7\u54c1\u7684\u4e34\u5e8a\u8f6c\u5316\uff0c\u6797\u6587\u658c\u6559\u6388\u521b\u7acb\u4e86\u540d\u4e3aCoordination Pharmaceuticals\u7684\u751f\u7269\u533b\u836f\u516c\u53f8\uff0c\u76ee\u524d\u5df2\u6709\u4e09\u79cd\u836f\u7269\u5f00\u59cb\u4e34\u5e8aI\u671f\u7814\u7a76\u3002<\/p>\n

\u6797\u6587\u658c\u6559\u6388\u76ee\u524d\u5df2\u5728\u5305\u62ecNat. Chem.\uff0cNat. Biomed. Eng., Nat. Commun., Chem, J. Am. Chem. Soc., Angew. Chem. Int. Ed\uff0c\u7b49\u4e16\u754c\u9876\u7ea7\u6742\u5fd7\u4e0a\u53d1\u8868\u6587\u7ae0340\u4f59\u7bc7\uff0c\u6587\u7ae0\u88ab\u5f15\u7528\u8d85\u8fc746000\u6b21(h-index >100) \uff0c\u540c\u65f6\u4ed6\u8fd8\u62c5\u4efb\u591a\u672c\u8457\u540d\u6742\u5fd7\u7684\u987e\u95ee\uff0c\u6bd4\u5982Chem. Sci., Chem. Mater., ACS Catal, Inorganic Chemistry Frontiers \u548cAsian J. Org. Chem.\u7b49\uff0c\u6797\u6587\u658c\u6559\u6388\u5728\u79d1\u7814\u5de5\u4f5c\u4e2d\u53d6\u5f97\u7684\u5353\u8d8a\u6210\u5c31\uff0c\u4f7f\u5176\u4e8e2009\u5e74\u5165\u9009\u7531\u53d1\u8868\u6587\u7ae0\u5f71\u54cd\u56e0\u5b50\u786e\u5b9a\u76841999-2009\u5e74\u5ea6\u5168\u7403\u201c\u5341\u5927\u5316\u5b66\u5bb6\u201d(\u201cTop ten chemists\u201d\uff0cby Thomson Reuters)\u3002<\/p>\n

\u5de5\u4f5c\u6c47\u603b\u53ca\u76f8\u5173\u6587\u732e<\/strong><\/p>\n

\u5728\u7eb3\u7c73\u533b\u5b66\u4e0e\u514d\u75ab\u6cbb\u7597\u7ed3\u5408\u65b9\u9762\uff0c\u6797\u6587\u658c\u6559\u6388\u56e2\u961f\u5df2\u53d1\u8868\u7cfb\u5217\u5de5\u4f5c\uff0c\u5305\u62ec\u9996\u6b21\u5b9e\u73b0\u5149\u52a8\u529b\u6cbb\u7597\u4e0e\u514d\u75ab\u6cbb\u7597\u76f8\u7ed3\u5408\uff08J. Am. Chem. Soc. 2016<\/strong>, 138 (38), 12502-12510\uff09,\u4ee5\u53ca\u8fdb\u4e00\u6b65\u514b\u670d\u80bf\u7624\u4e4f\u6c27\u7684\u5149\u52a8\u529b\u6cbb\u7597\u7ed3\u5408\u68c0\u67e5\u70b9\u963b\u65ad\u514d\u75ab\u6cbb\u7597\uff08J. Am. Chem. Soc. 2018<\/strong>,140 (17), 5670-5673\uff09\uff1b\u9996\u6b21\u7cfb\u7edf\u6bd4\u8f83\u4e86\u4e0d\u540c\u653e\u7597\u589e\u654f\u5242\u4e0e\u8f90\u5c04\u589e\u5f3a\u7684\u6784\u6548\u5173\u7cfb\u7528\u4e8e\u63d0\u9ad8\u8fdc\u4f4d\u6548\u5e94\uff08Nature communications\uff0c2018<\/strong>\uff0c 9 (1), 2351\uff09\uff1b \u9996\u6b21\u63d0\u51fa\u4e86\u8f90\u5c04\u52a8\u529b\u5b66\u7597\u6cd5\u7528\u4e8e\u7ed3\u5408\u514d\u75ab\u6cbb\u7597\uff08Nature Biomedical Engineering\uff0c2018<\/strong>\uff0c2 (8), 600\uff09\u3002\u8fd9\u4e00\u7cfb\u5217\u5f00\u521b\u6027\u5de5\u4f5c\u5b9e\u73b0\u4e86\u5229\u7528\u7eb3\u7c73\u91d1\u5c5e\u6709\u673a\u6846\u67b6\u4ecb\u5bfc\u5c40\u90e8\u7597\u6cd5\u63d0\u9ad8\u80bf\u7624\u708e\u6027\u5e76\u534f\u540c\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u5242\u5b9e\u73b0\u7cfb\u7edf\u6027\u6297\u80bf\u7624\u514d\u75ab\u6fc0\u6d3b\u7684\u6784\u60f3\u3002<\/p>\n

\u672c\u6587\u7531CQR\u7f16\u8bd1\u3002<\/p>\n

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