{"id":179939,"date":"2019-07-12T06:30:43","date_gmt":"2019-07-11T22:30:43","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=179939"},"modified":"2019-07-11T16:00:53","modified_gmt":"2019-07-11T08:00:53","slug":"%e5%b7%b2%e6%a0%a1%e7%a8%bf%e4%bb%b6-chem-%e6%8a%a5%e9%81%93-%e5%8f%af%e7%a7%bb%e5%8a%a8%e7%a9%ba%e5%bf%83%e7%ba%b3%e7%b1%b3%e7%b2%92%e5%ad%90%e4%bd%9c%e4%b8%ba%e6%b4%bb%e6%80%a7%e6%b0%a7%e6%b8%85","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=179939","title":{"rendered":"Chem \u62a5\u9053: \u53ef\u79fb\u52a8\u7a7a\u5fc3\u7eb3\u7c73\u7c92\u5b50\u4f5c\u4e3a\u6d3b\u6027\u6c27\u6e05\u9664\u5242"},"content":{"rendered":"

\u3010\u80cc\u666f\u4ecb\u7ecd\u3011<\/strong><\/p>\n

\u5728\u751f\u7269\u6709\u673a\u4f53\u4e2d\uff0c\u5305\u542b\u8fc7\u6c27\u5316\u6c22\uff08H2<\/sub>O2<\/sub>\uff09\u3001\u7f9f\u57fa\u81ea\u7531\u57fa\uff08\u00b7OH\uff09\u7b49\u7684\u6d3b\u6027\u6c27\uff08ROS\uff09\u5904\u4e8e\u6b63\u5e38\u6c34\u5e73\u65f6\uff0c\u5728\u7ec6\u80de\u4fe1\u53f7\u4f20\u5bfc\u3001\u75c5\u539f\u4f53\u9632\u5fa1\u548c\u4f53\u5185\u5e73\u8861\u8d77\u7740\u5173\u952e\u7684\u4f5c\u7528\u3002\u7136\u800c\uff0c\u5927\u91cf\u7684ROS\u4f1a\u901a\u8fc7\u5f15\u8d77\u8102\u8d28\u8fc7\u6c27\u5316\u3001\u86cb\u767d\u8d28\u53d8\u6027\u548cDNA\u635f\u4f24\u800c\u5bf9\u7ec6\u80de\u4ea7\u751f\u4e0d\u5229\u5f71\u54cd\u3002\u8fd9\u4e9b\u4e0d\u826f\u53cd\u5e94\u53ef\u80fd\u5bfc\u81f4\u708e\u75c7\u3001\u764c\u75c7\u7b49\u8bb8\u591a\u4eba\u7c7b\u75be\u75c5\u3002\u57fa\u4e8e\u8fd9\u4e9b\u539f\u56e0\uff0c\u76ee\u524d\u5df2\u7ecf\u7814\u7a76\u4e86\u591a\u79cd\u7eb3\u7c73\u6750\u6599\u7528\u4e8e\u6e05\u9664\u4f53\u5185ROS\uff0c\u8fdb\u800c\u7ef4\u6301\u7ec6\u80de\u5185\u6c27\u5316\u8fd8\u539f\u5e73\u8861\u548c\u4fdd\u62a4\u8eab\u4f53\u514d\u53d7\u6c27\u5316\u635f\u4f24\u3002\u4f46\u662f\uff0c\u5927\u591a\u6570\u7eb3\u7c73\u6e05\u9664\u5242\u4e0d\u5177\u6709\u53ef\u79fb\u52a8\u6027\uff0c\u53ea\u80fd\u6d88\u9664\u6e05\u9664\u5242\u9644\u8fd1\u7684ROS\uff0c\u800c\u4e0d\u80fd\u4e3b\u52a8\u53bb\u6e05\u5904\u5176\u4ed6\u4f4d\u7f6e\u7684ROS\uff0c\u964d\u4f4e\u4e86\u5176\u6e05\u9664\u6548\u7387\u3002\u76ee\u524d\u4e3b\u8981\u662f\u901a\u8fc7\u589e\u52a0\u6e05\u9664\u5242\u7684\u7528\u91cf\u6765\u63d0\u9ad8\u6e05\u9664\u6548\u7387\uff0c\u4f46\u540c\u65f6\u4f1a\u589e\u5927\u5bf9\u7ec6\u80de\u7684\u6bd2\u6027\u3002\u53ef\u89c1\u589e\u52a0\u7eb3\u7c73\u6e05\u9664\u5242\u7684\u5242\u91cf\u5e76\u4e0d\u662f\u6700\u6709\u6548\u53bb\u9664ROS\u7684\u7b56\u7565\u3002\u56e0\u6b64\uff0c\u9700\u8981\u8bbe\u8ba1\u5728\u9700\u8981\u7684\u5730\u65b9\u7cbe\u786e\u91ca\u653eROS\u6e05\u9664\u5242\u4ee5\u63d0\u9ad8\u836f\u7269\u7684\u5229\u7528\u7387\u5e76\u6700\u5927\u9650\u5ea6\u5730\u964d\u4f4e\u6bd2\u526f\u4f5c\u7528\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u4e2d\u79d1\u9662\u5317\u5316\u6240\u7684\u738b\u94c1\u7814\u7a76\u5458\u548c\u5317\u4eac\u5316\u5de5\u5927\u5b66\u7684\u9648\u65ed\u6559\u6388\uff08\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u8054\u5408\u62a5\u9053\u4e86\u5229\u7528\u8d1f\u8f7d\u6c2f\u5316\u8840\u7ea2\u7d20\u7684\u4ecb\u5b54\u4e8c\u6c27\u5316\u7845\u7eb3\u7c73\u7c92\u5b50\uff08hemin-MSNs\uff09\u4f5c\u4e3a\u53ef\u79fb\u52a8\u7684\u7eb3\u7c73\u7c92\u5b50\u6a21\u578b\uff0c\u7528\u6765\u6e05\u9664\u7ec6\u80de\u5728\u6c27\u5316\u5e94\u6fc0\u4e0b\u5185\u6e90\u6027\u4ea7\u751f\u7684ROS\u3002\u5176\u4e2d\uff0cROS\u662f\u88ab\u6c2f\u5316\u8840\u7ea2\u7d20\u50ac\u5316\u5206\u89e3\uff0c\u5176\u4ea7\u751f\u7684\u5316\u5b66\u80fd\u4e3ahemin-MSNs\u5728\u7ec6\u80de\u5185\u79fb\u52a8\u63d0\u4f9b\u4e86\u52a8\u529b\u3002\u6587\u4e2d\u5236\u5907\u4e86\u4e09\u79cd\u7c7b\u578b\u7684hemin-MSNs\uff0c\u5206\u522b\u662f\u8d1f\u8f7d\u8840\u7ea2\u7d20\u7684\u56fa\u4f53\u4ecb\u5b54\u4e8c\u6c27\u5316\u7845\u7eb3\u7c73\u7c92\u5b50\uff08hemin-SMSNs\uff09\u3001\u8d1f\u8f7d\u6c2f\u5316\u8840\u7ea2\u7d20\u7684\u539a\u58c1\u4ecb\u5b54\u4e8c\u6c27\u5316\u7845\u7eb3\u7c73\u7c92\u5b50\uff08hemin-TMSNs\uff09\u548c\u8d1f\u8f7d\u6c2f\u5316\u8840\u7ea2\u7d20\u7684\u7a84\u58c1\u4ecb\u5b54\u4e8c\u6c27\u5316\u7845\u7eb3\u7c73\u7c92\u5b50\uff08hemin-NMSNs\uff09\uff0c\u901a\u8fc7\u7cfb\u7edf\u7684\u8bc4\u4f30\u8fd9\u4e9b\u7eb3\u7c73\u6750\u6599\u7684\u8fd0\u52a8\u6027\u80fd\u53ca\u5176\u4f53\u5916\u548c\u4f53\u5185\u6297\u6c27\u5316\u884c\u4e3a\u4e4b\u95f4\u7684\u5173\u7cfb\u3002\u5176\u4e2d\uff0cHemin-NMSNs\u5728\u4f53\u5916\u548c\u4f53\u5185\u5747\u6709\u4f18\u5f02\u7684\u6297\u6c27\u5316\u6548\u7387\u3002\u53ef\u79fb\u52a8\u7684ROS\u6e05\u9664\u5242\u964d\u4f4e\u4e86\u4e0e\u9ad8\u5242\u91cf\u8840\u7ea2\u7d20\u6f5c\u5728\u6bd2\u6027\u76f8\u5173\u7684\u5b89\u5168\u6027\u95ee\u9898\u3002\u8be5\u7b56\u7565\u65e2\u53ef\u4ee5\u6269\u5c55\u7528\u4e8eROS\u6e05\u9664\u5242\u7684\u5404\u79cd\u4e2d\u7a7a\u7eb3\u7c73\u9897\u7c92\u7684\u5f00\u53d1\u4e2d\uff0c\u53c8\u53ef\u4ee5\u7528\u4e8e\u8c03\u8282ROS\u7684\u6e05\u9664\u6548\u7387\u548c\u57fa\u4e8eROS\u7684\u6cbb\u7597\u5242\u7684\u5e7f\u6cdb\u5e94\u7528\u4e2d\u3002\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a\u201cMovable Hollow Nanoparticles as Reactive Oxygen Scavengers\u201d<\/strong>\u53d1\u8868\u5728\u56fd\u9645\u8457\u540d\u671f\u520aChem<\/strong>\u4e0a\u3002
\n \"\"\u672c\u6587\u4eae\u70b9\uff1a<\/span><\/strong><\/p>\n

1\u3001\u53ef\u79fb\u52a8\u7684\u4e2d\u7a7a\u7eb3\u7c73\u9897\u7c92\u53ef\u4ee5\u6709\u6548\u7684\u53bb\u9664\u7ec6\u80de\u5185ROS\uff1b<\/strong><\/p>\n

2\u3001\u7a7a\u5fc3NPs\u7684\u6e05\u9664\u80fd\u529b\u5927\u4e8e\u56fa\u4f53NPs\u548c\u6e38\u79bb\u6c2f\u5316\u8840\u7ea2\u7d20\uff1b<\/strong><\/p>\n

3\u3001\u53ef\u79fb\u52a8\u7684\u4e2d\u7a7a\u7eb3\u7c73\u590d\u5408\u7269\u51cf\u8f7b\u4e86\u9ad8\u5242\u91cf\u836f\u7269\u7684\u6bd2\u6027\uff1b<\/strong><\/p>\n

4\u3001\u8be5\u7b56\u7565\u5141\u8bb8\u8bbe\u8ba1\u5404\u79cd\u7a7a\u5fc3\u7eb3\u7c73ROS\u6e05\u9664\u5242\uff0c\u5177\u6709\u901a\u7528\u6027\u3002<\/strong><\/p>\n

\u3010\u56fe\u6587\u89e3\u8bfb\u3011<\/strong><\/p>\n

\u56fe\u4e00\u3001Hemin-MSNs\u7684\u8868\u5f81\u548c\u8fd0\u52a8\u884c\u4e3a<\/strong><\/p>\n

\"\"\uff08A-C\uff09TEM\u56fe\u663e\u793ahemin-SMSNs\u7684\u5e73\u5747\u76f4\u5f84\u4e3a\u7ea6630 nm\u3001hemin-TMSNs\u7684\u58f3\u539a\u5ea6\u4e3a150 nm\u548chemin-NMSNs\u7684\u58f3\u539a\u5ea6\u4e3a70 nm\uff1b<\/p>\n

\uff08D\uff09\u5177\u6709\u4ee3\u8868\u6027\u7684\u8ddf\u8e2a\u8f68\u8ff9\u8868\u660e\uff0c\u4e0d\u540c\u58f3\u539a\u7684Hemin-MSNs\u7684\u6269\u6563\u589e\u5f3a\uff1b<\/p>\n

\uff08E\uff09\u572830 mM H2<\/sub>O2<\/sub>\u5b58\u5728\u4e0b\uff0chemin-MSNs\u7684\u5e73\u5747\u901f\u5ea6\u548c\u6269\u6563\u7cfb\u6570\u3002<\/p>\n

\u56fe\u4e8c\u3001Hemin-MSNs\u8fd0\u52a8\u7684\u673a\u5236<\/strong><\/p>\n

\"\"\uff08A\uff09hemin-SMSNs\u548chemin-NMSNs\u4e0eH2<\/sub>O2<\/sub>\u77ac\u65f6\u53cd\u5e94\u7684\u70ed\u901a\u91cf\u56fe\uff1b<\/p>\n

\uff08B\uff09hemin-MSNs\u7684\u8fd0\u52a8\u673a\u5236\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08C\uff09Hemin-MSNs\u7684\u8ddf\u8e2a\u8f68\u8ff9\u548c\u6269\u6563\u7cfb\u6570\u4e0e402 nm\u6fc0\u5149\u529f\u7387\u7684\u51fd\u6570\u5173\u7cfb\u793a\u610f\u56fe\u3002<\/p>\n

\u56fe\u4e09\u3001Hemin-MSNs\u7684ROS\u6e05\u9664\u6d3b\u6027<\/strong>
\n \"\"\uff08A\uff09\u7528H2<\/sub>O2<\/sub>\u5bf9\u6c2f\u5316\u8840\u7ea2\u86cb\u767d-MSNs\u8fdb\u884c\u7a33\u6001\u52a8\u529b\u5b66\u6d4b\u5b9a\uff1b<\/p>\n

\uff08B-C\uff09\u6c2f\u5316\u7269-MSNs\u5bf9\u8d85\u6c27\u81ea\u7531\u57fa\u548c\u7f9f\u57fa\u81ea\u7531\u57fa\u7684\u6e05\u9664\u6548\u7387\uff1b<\/p>\n

\uff08D\uff09\u5404\u79cdROS\u6e05\u9664\u5242\u5904\u7406\u540e\u7684HUVEC\u7ec6\u80de\u7684\u8367\u5149\u663e\u5fae\u56fe\uff1b<\/p>\n

\uff08E\uff09\u7ec6\u80de\u5185hemin-MSNs\u7684\u53ef\u9006\u8f68\u8ff9\u3002<\/p>\n

\u56fe\u56db\u3001Hemin\u548cHemin-NMSNs\u7684ROS\u6e05\u9664\u6d3b\u6027<\/strong>
\n \"\"\uff08A-B\uff09hemin\u548chemin-NMSNs\u5904\u7406\u540e\uff0cHUVEC\u7ec6\u80de\u7684\u8367\u5149\u663e\u5fae\u56fe\uff1b<\/p>\n

\uff08C\uff09\u5404\u79cd\u5904\u7406\u540e\uff0cHUVEC\u7ec6\u80de\u7684\u8367\u5149\u663e\u5fae\u7167\u7247\u4e2dDCFH-DA\u7684\u76f8\u5e94\u8367\u5149\u5f3a\u5ea6\uff0c\u4ee5\u53ca\u4e0ehemin\u548chemin-NMSNs\u5b75\u80b2\u540e\u7684\u7ec6\u80de\u5b58\u6d3b\u7387\uff1b<\/p>\n

\uff08D\uff09\u7528\u4e0d\u540c\u6750\u6599\u5904\u7406\u540e\uff0c\u5177\u6709PMA\u8bf1\u5bfc\u7684\u5c0f\u9f20\u4f53\u5185\u8367\u5149\u56fe\u50cf\u3002<\/p>\n

\u56fe\u4e94\u3001\u7a7a\u5fc3\u7eb3\u7c73\u7c92\u5b50\u6e05\u9664ROS\u7684\u901a\u7528\u6027<\/strong>
\n \"\"\uff08A-H\uff09\uff08A\uff09170 nm hemin-SMSNs\u3001\uff08B\uff09170 nm hemin-NMSNs\u3001\uff08C\uff09hemin-SCSs\u3001\uff08D\uff09hemin-HCSs\u3001\uff08E\uff09hemin-MnO2<\/sub>\u3001\uff08F\uff09Pd\u7eb3\u7c73\u9897\u7c92\u3001\uff08G\uff09AuPd\u7eb3\u7c73\u7c92\u5b50\u548c\uff08H\uff09Pt\u7eb3\u7c73\u7c92\u5b50\u7684TEM\u548c\u4f5c\u7528\u4e8e\u7ec6\u80de\u540e\u7684\u8367\u5149\u663e\u5fae\u56fe\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

\u7efc\u4e0a\u6240\u8ff0\uff0c\u4f5c\u8005\u63d0\u51fa\u4e86\u4e00\u79cd\u81ea\u6211\u9a71\u52a8\u7684ROS\u6e05\u9664\u7cfb\u7edf\uff0c\u5e76\u9a8c\u8bc1\u4e86\u5176\u5728\u7ec6\u80de\u548c\u5c0f\u9f20\u6a21\u578b\u4e2d\u5177\u6709\u4f18\u5f02\u7684ROS\u6e05\u9664\u6027\u80fd\u3002\u8fd9\u4e9b\u7a7a\u5fc3\u7ed3\u6784\u7684\u5e73\u5747\u901f\u5ea6\u6bd4\u5b9e\u5fc3\u7ed3\u6784\u7684\u5e73\u5747\u901f\u5ea6\u9ad83.5\u500d\u3002\u7a7a\u5fc3\u7ed3\u6784\u5c40\u90e8\u52a0\u70ed\u5bfc\u81f4\u663e\u7740\u7684\u975e\u5b9a\u5411\u81ea\u4e3b\u8fd0\u52a8\u3002\u6b64\u5916\uff0c\u4f5c\u8005\u8fd8\u8bc4\u4f30\u4e86\u5176\u4ed6\u4e2d\u7a7a\u7ed3\u6784\u7528\u4e8e\u6e05\u9664ROS\u548c\u4fdd\u62a4\u7ec6\u80de\u514d\u53d7\u6c27\u5316\u635f\u4f24\u7684\u6027\u80fd\u3002\u603b\u4e4b\uff0c\u6587\u4e2d\u5173\u4e8e\u901a\u8fc7\u8c03\u8282\u79fb\u52a8\u7eb3\u7c73\u9897\u7c92\u7684\u5e73\u5747\u901f\u5ea6\u6765\u8c03\u8282ROS\u53bb\u9664\u6548\u7387\u7684\u5b9e\u9a8c\u7ed3\u679c\uff0c\u4e3a\u8bbe\u8ba1\u57fa\u4e8e\u7eb3\u7c73\u6750\u6599\u7684\u5177\u6709\u9ad8\u50ac\u5316\u6d3b\u6027\u7684\u4eff\u9176\u50ac\u5316\u5242\u6253\u5f00\u4e86\u5927\u95e8\uff0c\u672a\u6765\u53ef\u4ee5\u4f5c\u4e3a\u4e0e\u6c27\u5316\u5e94\u6fc0\u76f8\u5173\u7684\u4e34\u5e8a\u75c5\u75c7\u6cbb\u7597\u5242\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aMovable Hollow Nanoparticles as Reactive Oxygen Scavengers<\/a><\/strong>. (Chem, 2019<\/strong>, DOI: 10.1016\/j.chempr.2019.05.023)<\/p>\n

\u672c\u6587\u7531CQR\u7f16\u8bd1\u3002<\/p>\n

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