{"id":180241,"date":"2019-07-13T16:10:45","date_gmt":"2019-07-13T08:10:45","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=180241"},"modified":"2019-07-13T16:10:45","modified_gmt":"2019-07-13T08:10:45","slug":"%e5%b1%b1%e8%a5%bf%e5%a4%a7%e5%ad%a6%e9%98%b4%e5%bd%a9%e9%9c%9echem-soc-rev-%e7%bb%bc%e8%bf%b0-%e7%94%a8%e4%ba%8e%e9%80%89%e6%8b%a9%e6%80%a7%e9%9d%b6%e5%90%91%e3%80%81%e5%a4%9a%e5%88%86%e6%9e%90","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=180241","title":{"rendered":"\u5c71\u897f\u5927\u5b66\u9634\u5f69\u971eChem. Soc. Rev.\u7efc\u8ff0: \u7528\u4e8e\u9009\u62e9\u6027\u9776\u5411\u3001\u591a\u5206\u6790\u7269\u68c0\u6d4b\u4e0e\u6210\u50cf\u7684\u529f\u80fd\u6027\u5408\u6210\u63a2\u9488"},"content":{"rendered":"

\u3010\u80cc\u666f\u4ecb\u7ecd\u3011<\/strong><\/p>\n

\u8367\u5149\u63a2\u9488\u4f5c\u4e3a\u4e00\u79cd\u5f3a\u5927\u7684\u201c\u4fa6\u67e5\u201d\u5de5\u5177\uff0c\u5b83\u5f7b\u5e95\u6539\u53d8\u4e86\u6211\u4eec\u68c0\u6d4b\u548c\u76d1\u6d4b\u751f\u7269\u6d3b\u6027\u5206\u5b50\u7684\u80fd\u529b\u3002\u5728\u8fc7\u53bb\u7684\u534a\u4e2a\u4e16\u7eaa\u91cc\uff0c\u6210\u5343\u4e0a\u4e07\u79cd\u57fa\u4e8e\u529f\u80fd\u5316\u6709\u673a\u5c0f\u5206\u5b50\u67d3\u6599\u3001\u8367\u5149\u86cb\u767d\u548c\u7eb3\u7c73\u7c92\u5b50\u7684\u8367\u5149\u63a2\u9488\u5df2\u7ecf\u88ab\u5f00\u53d1\u51fa\u6765\u3002\u5176\u4e2d\u8bb8\u591a\u65b9\u6cd5\u8fd8\u80fd\u591f\u5b9e\u65f6\u3001\u9ad8\u7075\u654f\u5ea6\u3001\u9009\u62e9\u6027\u548c\u91cd\u73b0\u6027\u5730\u6d4b\u5b9a\u751f\u7269\u548c\u73af\u5883\u4e2d\u7684\u5206\u5b50\u3001\u79bb\u5b50\u7b49\u3002\u4e0e\u4f20\u7edf\u7684\u5355\u7ed3\u5408\u4f4d\u70b9\u63a2\u9488\u4ee5\u53ca\u7279\u5b9a\u5206\u6790\u7269\u7ed3\u5408\u7684\u8bbe\u8ba1\u4e0d\u540c\uff0c\u5177\u6709\u591a\u4e2a\u76f8\u4e92\u4f5c\u7528\u4f4d\u70b9\u7684\u63a2\u9488\u6216\u5177\u6709\u4fc3\u8fdb\u5bf9\u76ee\u6807\u4e00\u79cd\u6216\u591a\u79cd\u5206\u6790\u7269\u4e32\u8054\u53cd\u5e94\u7684\u5355\u4f4d\u70b9\u63a2\u9488\uff0c\u5176\u88ab\u5e7f\u6cdb\u7528\u4e8e\u89e3\u51b3\u7ed3\u6784\u76f8\u4f3c\u7684\u5316\u5408\u7269\u548c\u590d\u6742\u57fa\u8d28\u4e2d\u5b58\u5728\u9009\u62e9\u6027\u9776\u5411\u7684\u56fa\u6709\u6311\u6218\uff0c\u4ee5\u53ca\u5982\u6d3b\u6027\u786b\uff0c\u6d3b\u6027\u6c27\uff0c\u6838\u82f7\u9178\u548c\u9176\u7b49\u5206\u6790\u7269\u4e4b\u95f4\u7684\u4f53\u5185\u76f8\u4e92\u4f5c\u7528\u6216\u4e32\u6270\u7684\u53ef\u89c6\u5316\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u6700\u8fd1\uff0cChem. Soc. Rev.<\/strong>\u5728\u7ebf\u520a\u767b\u4e86\u5c71\u897f\u5927\u5b66\u9634\u5f69\u971e\u6559\u6388<\/strong>\u548c\u6ce2\u7279\u5170\u5dde\u7acb\u5927\u5b66Robert M. Strongin\u6559\u6388<\/strong>\u7b49\u603b\u7ed3\u7684\u7528\u4e8e\u9009\u62e9\u6027\u9776\u5411\u3001\u591a\u5206\u6790\u7269\u68c0\u6d4b\u4e0e\u6210\u50cf\u7684\u529f\u80fd\u6027\u5408\u6210\u63a2\u9488\u7814\u7a76\u8fdb\u5c55\u7684\u7efc\u8ff0\u3002\u9898\u76ee\u662f\u201cFunctional synthetic probes for selective targeting and multi-analyte detection and imaging<\/strong>\u201d\u3002\u5728\u8fd9\u7bc7\u7efc\u8ff0\u4e2d\uff0c\u4f5c\u8005\u7efc\u8ff0\u4e86\u8fd1\u5e74\u6765\u5728\u63a2\u9488\u8bbe\u8ba1\u3001\u68c0\u6d4b\u673a\u5236\u548c\u751f\u7269\u8fc7\u7a0b\u7814\u7a76\u7b49\u65b9\u9762\u7684\u521b\u65b0\u53d1\u5c55\u3002\u8ba8\u8bba\u4e86\u591a\u5206\u6790\u9776\u5411\u63a2\u9488\u7684\u5e94\u7528\u524d\u666f\u4ee5\u53ca\u6240\u9762\u4e34\u7684\u6311\u6218\uff0c\u63d0\u51fa\u4e86\u4f5c\u8005\u7684\u4e00\u4e9b\u89c1\u89e3\u548c\u5efa\u8bae\uff0c\u5e76\u671f\u671b\u5176\u80fd\u4fc3\u8fdb\u591a\u5206\u6790\u9776\u5411\u8367\u5149\u63a2\u9488\u7684\u4e0d\u65ad\u53d1\u5c55\uff0c\u4ee5\u4fbf\u66f4\u6df1\u5165\u5730\u4e86\u89e3\u751f\u7269\u751f\u7406\u5b66\u8fc7\u7a0b\u3002<\/p>\n

\u3010\u56fe\u6587\u89e3\u8bfb\u3011<\/strong><\/p>\n

1\u3001\u5f15\u8a00<\/strong><\/p>\n

2\u3001\u901a\u8fc7\u5355\u53cd\u5e94\u4f4d\u70b9\u9776\u5411\u591a\u79cd\u5206\u6790\u7269\u7684\u63a2\u9488<\/strong><\/p>\n

2.1\u3001\u5177\u6709\u5355\u7ed3\u5408\u4f4d\u70b9\u7684\u63a2\u9488\u7528\u4e8e\u68c0\u6d4b\u591a\u79cd\u786b\u9187\u5206\u6790\u7269<\/strong><\/p>\n

\u56fe\u4e00\u3001\u4e09\u79cd\u6700\u5e38\u7528\u4e8e\u68c0\u6d4b\u7684\u5c0f\u5206\u5b50\u6c28\u57fa\u786b\u9187<\/strong>
\n \"\"\u56fe\u4e8c\u3001\u57fa\u4e8e\u5def\u57fa\u53d6\u4ee3\u53cd\u5e94\u7684\u63a2\u9488<\/strong>
\n \"\"\u63a2\u94881~4\u4ee5\u53ca1\u4e0eGSH\uff0cCys\u548cHcy\u7684\u53cd\u5e94\u3002\u800c\u5177\u6709\u7ed9\u7535\u5b50R\u57fa\u56e2\u7684\u5316\u5408\u72691e\u548c1f\u662f\u975e\u53cd\u5e94\u6027\u7684\u3002<\/p>\n

\u56fe\u4e09\u3001\u57fa\u4e8e\u5def\u57fa\u53d6\u4ee3\u53cd\u5e94\u7684\u63a2\u9488<\/strong>
\n \"\"\u56fe\u56db\u3001\u901a\u8fc7PET\u548cESIPT\u8fc7\u7a0b\u7528\u4e8e\u53cc\u901a\u9053GSH\u548cCys\/Hcy\u68c0\u6d4b<\/strong>
\n \"\"\u56fe\u4e94\u3001\u57fa\u4e8eNBD\u884d\u751f\u7269\u7684GSH\u548cCys\/Hcy\u591a\u8272\u786b\u9187\u63a2\u9488<\/strong>
\n \"\"\u56fe\u516d\u3001\u7528\u4e8e\u68c0\u6d4b\u6c28\u57fa\u786b\u9187\u548cH2<\/sub>S\u63a2\u9488<\/strong>
\n \"\"\u56fe\u4e03\u3001\u57fa\u4e8e\u786b\u9187-\u70ef\u57fa\u5171\u8f6d\u52a0\u6210\/\u73af\u5316\u53cd\u5e94\u7684\u63a2\u9488<\/strong>
\n \"\"\u56fe\u516b\u3001\u57fa\u4e8epH\u63a7\u5236\u7684\u9009\u62e9\u6027\u68c0\u6d4b\u6d3b\u6027\u786b\u9187\u63a2\u9488<\/strong>
\n \"\"2.2\u3001\u7528\u4e8e\u975e\u786b\u9187\u5206\u6790\u7269\u68c0\u6d4b\u7684\u5355\u7ed3\u5408\u4f4d\u70b9\u63a2\u9488<\/strong><\/p>\n

\u56fe\u4e5d\u3001\u7528\u4e8e\u68c0\u6d4bClO–<\/sup>\u548cONOO–<\/sup>\u7b49ROS\u6216RNS\u63a2\u9488<\/strong>
\n \"\"\u56fe\u5341\u3001\u7528\u4e8e\u7814\u7a76ClO–<\/sup>\u548c\u6c27\u5316\u5e94\u6fc0\u5bf9SO2<\/sub>\u529f\u80fd\u5f71\u54cd\u7684\u63a2\u9488<\/strong>
\n \"\"3\u3001\u9488\u5bf9\u5355\u4e00\u5206\u6790\u7269\u7684\u591a\u4e2a\u53cd\u5e94\u4f4d\u70b9\u63a2\u9488<\/strong><\/p>\n

3.1\u3001\u53cc\u53cd\u5e94\u4f4d\u70b9\u63a2\u9488\u7528\u4e8e\u68c0\u6d4bH2<\/sub>S<\/strong><\/p>\n

\u56fe\u5341\u4e00\u3001\u5177\u6709\u4e24\u4e2a\u4eb2\u7535\u4f4d\u70b9\u7528\u4e8e\u9009\u62e9\u6027\u68c0\u6d4bH2<\/sub>S\u7684\u63a2\u9488<\/strong>
\n \"\"\u56fe\u5341\u4e8c\u3001\u4e24\u53ef\u4eb2\u7535\u7684H2<\/sub>S\u63a2\u9488<\/strong>
\n \"\"\u56fe\u5341\u4e09\u3001\u4e24\u53ef\u4eb2\u7535\u7684H2<\/sub>S\u63a2\u9488<\/strong>
\n \"\"3.2\u3001\u5177\u6709\u591a\u4e2a\u7ed3\u5408\u4f4d\u70b9\u7684\u63a2\u9488\u7528\u4e8e\u68c0\u6d4bATP<\/strong><\/p>\n

\u56fe\u5341\u56db\u3001\u7ed3\u6784\u76f8\u4f3c\u7684\u751f\u7269\u78f7\u9178\u76d0\u5316\u5408\u7269<\/strong>
\n \"\"\u56fe\u5341\u4e94\u3001\u53cc\u7ed3\u5408\u4f4d\u70b9\u63a2\u9488\u7528\u4e8eATP\u68c0\u6d4b<\/strong>
\n \"\"\u56fe\u5341\u516d\u3001\u57fa\u4e8e\u03c0-\u03c0\u76f8\u4e92\u4f5c\u7528\u3001\u7ed3\u5408\u8377\u7535\u6c22\u952e\u9009\u62e9\u6027ATP\u63a2\u9488<\/strong>
\n \"\"\u56fe\u5341\u4e03\u3001\u591a\u4e2a\u7ed3\u5408\u4f4d\u70b9\u63a2\u9488\u7528\u4e8e\u7ec6\u80de\u5185ATP\u6210\u50cf<\/strong>
\n \"\"\u56fe\u50cf\u663e\u793aKCN\u6291\u5236\u7ebf\u7c92\u4f53ATP\u5408\u6210\uff08A\uff09\uff0c\u559c\u6811\u78b1\u8bf1\u5bfc\u7ec6\u80de\u51cb\u4ea1\u65f6ATP\u6c34\u5e73\u5347\u9ad8\uff08B\uff09<\/p>\n

\u56fe\u5341\u516b\u3001ATP\u6fc0\u6d3b\u7684FRET\u5171\u8f6d\u805a\u5408\u7269\u63a2\u9488<\/strong>
\n \"\"\u56fe\u5341\u4e5d\u3001\u6eb6\u9176\u4f53ATP\u68c0\u6d4b\u63a2\u9488\u53ca\u5176\u5728\u819c\u878d\u5408\u8fc7\u7a0b\u53ef\u89c6\u5316\u4e2d\u7684\u5e94\u7528<\/strong>
\n \"\"\uff08a~b\uff09\u6eb6\u9176\u4f53\u7684\u53cc\u5149\u5b50\u6d3b\u7ec6\u80de\u56fe\u50cf\uff0c\u7ecf\u5386\uff08a\uff09\u201c\u4eb2\u543b\u5e76\u8fd0\u884c\u201d\u548c\uff08b\uff09\u201c\u5b8c\u5168\u5d29\u89e3\u878d\u5408\u201d\u8fc7\u7a0b\uff1b<\/p>\n

\uff08c\uff09\uff08a\uff09\u4e2d\u4e24\u79cd\u6eb6\u9176\u4f53\u6bd4\u503c\u7684\u53d8\u5316\uff1b<\/p>\n

\uff08d\uff09\u4e24\u79cd\u6eb6\u9176\u4f53\u5f00\u59cb\u548c\u6700\u540e10\u79d2\u5e73\u5747\u6bd4\u503c\u7684\u6bd4\u8f83\uff1b<\/p>\n

\uff08e\uff09\uff08a\uff09\u4e2d\u4e24\u79cd\u6eb6\u9176\u4f53\u6bd4\u503c\u7684\u53d8\u5316\uff1b<\/p>\n

\uff08f\uff09\u878d\u5408\u524d\u540e\u6eb6\u9176\u4f53\u5e73\u5747\u6bd4\u503c\u7684\u6bd4\u8f83\u3002<\/p>\n

3.3\u3001\u53cc\u53cd\u5e94\u4f4d\u70b9\u63a2\u9488\u7528\u4e8e\u68c0\u6d4b\u786b\u9187\u3001\u805a\u786b\u5316\u7269\u3001pH\u548c\u53bb\u7532\u80be\u4e0a\u817a\u7d20\uff08NE\uff09<\/strong><\/p>\n

\u56fe\u4e8c\u5341\u3001\u53cc\u7ed3\u5408\u4f4d\u70b9\u7684GSH\u63a2\u9488<\/strong>
\n \"\"\u56fe\u4e8c\u5341\u4e00\u3001\u53cc\u53cd\u5e94\u4f4d\u70b9\u7684Cys\u9009\u62e9\u6027\u63a2\u9488<\/strong>
\n \"\"\u56fe\u4e8c\u5341\u4e8c\u3001\u53cc\u53cd\u5e94\u4f4d\u70b9Cys\u9776\u5411\u63a2\u9488\u6bd4\u76f8\u5e94\u7684\u5355\u53cd\u5e94\u4f4d\u70b9\u5bf9\u7167\u63a2\u9488\u66f4\u5177\u6709\u9009\u62e9\u6027<\/strong>
\n \"\"\u56fe\u4e8c\u5341\u4e09\u3001\u53cc\u53cd\u5e94\u4f4d\u70b9H2<\/sub>Sn<\/sub>\u63a2\u9488<\/strong>
\n \"\"\u56fe\u4e8c\u5341\u56db\u3001\u53cc\u53cd\u5e94\u4f4d\u70b9pH\u63a2\u9488<\/strong>
\n \"\"\u56fe\u4e8c\u5341\u4e94\u3001\u7528\u4e8e\u5c0f\u9f20\u8111\u7ec4\u7ec7\u53bb\u7532\u80be\u4e0a\u817a\u7d20\u7684\u68c0\u6d4b\u548c\u6807\u8bb0\u63a2\u9488<\/strong>
\n \"\"4\u3001\u5177\u6709\u591a\u4e2a\u53cd\u5e94\u4f4d\u70b9\u9488\u5bf9\u591a\u4e2a\u5206\u6790\u7269\u68c0\u6d4b\u7684\u63a2\u9488<\/strong><\/p>\n

4.1\u3001\u5177\u6709\u591a\u4e2a\u53cd\u5e94\u4f4d\u70b9\u7684\u786b\u9187\u68c0\u6d4b\u63a2\u9488<\/strong><\/p>\n

\u56fe\u4e8c\u5341\u516d\u3001\u591a\u53cd\u5e94\u4f4d\u70b9\u786b\u9187\u63a2\u9488\u53ca\u5176\u4e0e\u786b\u9187\u7684\u53cd\u5e94<\/strong>
\n \"\"\u56fe\u4e8c\u5341\u4e03\u3001\u53cc\u53cd\u5e94\u4f4d\u70b9\u786b\u9187\u63a2\u9488<\/strong>
\n \"\"\u56fe\u4e8c\u5341\u516b\u3001\u7528\u4e8e\u68c0\u6d4bGSH\u548cCys\u7684\u53cc\u53cd\u5e94\u4f4d\u70b9\u63a2\u9488<\/strong>
\n \"\"\u56fe\u4e8c\u5341\u4e5d\u3001\u53cc\u53cd\u5e94\u4f4d\u70b9\u63a2\u9488\u7528\u4e8e\u4e09\u901a\u9053\u786b\u9187\u6210\u50cf<\/strong>
\n \"\"\u56fe\u4e09\u5341\u3001Cys\u4ee3\u8c22\u63a2\u9488<\/strong>
\n \"\"\u56fe\u4e09\u5341\u4e00\u3001\u7528\u4e8eCys\u5206\u89e3\u4ee3\u8c22\u6210\u50cf\u7684\u63a2\u9488<\/strong>
\n \"\"4.2\u3001\u591a\u53cd\u5e94\u4f4d\u70b9\u63a2\u9488\u7528\u4e8e\u68c0\u6d4b\u5176\u4ed6\u786b\u884d\u751f\u7269<\/strong><\/p>\n

\u56fe\u4e09\u5341\u4e8c\u3001\u7528\u4e8eH2<\/sub>Sn<\/sub>\u548cH2<\/sub>S\u6210\u50cf\u7684\u63a2\u9488<\/strong>
\n \"\"\u5c06HeLa\u7ec6\u80de\u4e0e\u63a2\u9488\u5b75\u80b2\uff0c\u7528\uff08a\u3001e\uff09\u65e0\u6dfb\u52a0\u7269\u5904\u7406\uff1b\uff08b\u3001f\uff09Na2<\/sub>S\uff1b\uff08c\u3001g\uff09Na2<\/sub>S\u548cNaClO\uff1b\uff08d\u3001h\uff09Na2<\/sub>S2<\/sub>\u5904\u7406\u540e\u7684\u7ec6\u80de\u4e0d\u540c\u901a\u9053\u8367\u5149\u6210\u50cf\u3002<\/p>\n

\u56fe\u4e09\u5341\u4e09\u3001\u7528\u4e8eGSH\u548cH2<\/sub>S\u6210\u50cf\u7684\u63a2\u9488<\/strong>
\n \"\"\u56fe\u4e09\u5341\u56db\u3001\u7528\u4e8eGSH\u548cH2<\/sub>Sn<\/sub>\u6210\u50cf\u7684\u63a2\u9488<\/strong>
\n \"\"\u56fe\u4e09\u5341\u4e94\u3001\u53ef\u5b9e\u73b0\u591a\u8272\u68c0\u6d4b\u7684\u786b\u9187\u548cH2<\/sub>S\u63a2\u9488<\/strong>
\n \"\"4.3\u3001\u591a\u53cd\u5e94\u4f4d\u70b9\u63a2\u9488\u7528\u4e8e\u68c0\u6d4bROS\u3001H2<\/sub>S\u548cRNS<\/strong><\/p>\n

\u56fe\u4e09\u5341\u516d\u3001H2<\/sub>O2<\/sub>\u548cNO\u63a2\u9488<\/strong>
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\"\"\u56fe\u56db\u5341\u4e00\u3001\u591a\u53cd\u5e94\u4f4d\u70b9\u63a2\u9488\u540c\u65f6\u68c0\u6d4bMMP-2\u548ccaspase-3<\/strong>
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\u6587\u732e\u94fe\u63a5\uff1a Functional synthetic probes for selective targeting and multi-analyte detection and imaging<\/a>\uff08Chem. Soc. Rev.<\/em> 2019,<\/strong> DOI: 10.1039\/c8cs01006d\uff09<\/p>\n

\n \u672c\u6587\u7531\u6211\u4ea6\u662f\u884c\u4eba\u7f16\u8bd1\u6574\u7406\u3002<\/p>\n

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