{"id":180639,"date":"2019-07-18T06:30:01","date_gmt":"2019-07-17T22:30:01","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=180639"},"modified":"2019-07-17T13:54:26","modified_gmt":"2019-07-17T05:54:26","slug":"%e3%80%90%e5%b7%b2%e6%a0%a1%e7%a8%bf%e3%80%91%e6%96%bd%e5%89%91%e6%9e%97%e6%9c%80%e6%96%b0jacs%ef%bc%9a%e5%8e%9f%e4%bd%8d%e9%93%9c%e8%9e%af%e5%90%88%e5%bc%95%e5%8f%91%e6%97%a0%e6%af%92","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=180639","title":{"rendered":"\u65bd\u5251\u6797\u6700\u65b0JACS\uff1a\u539f\u4f4d\u94dc\u87af\u5408\u5f15\u53d1\u201c\u65e0\u6bd2-\u6709\u6bd2\u201d\u7684\u8f6c\u6362\u589e\u5f3a\u53cc\u786b\u4ed1\u5316\u7597\u4f5c\u7528"},"content":{"rendered":"

\u3010\u7814\u7a76\u80cc\u666f\u3011<\/strong><\/p>\n

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\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

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\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

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\n \"\"
\n DSF@PEG\/Cu-HMSNs\u7eb3\u7c73\u836f\u7269\u7684\u4f5c\u7528\u539f\u7406\u56fe\uff0c\u4ee5\u53caROS\u4e0eCuETs\u5728\u589e\u5f3aDSF\u5316\u7597\u7597\u6548\u65b9\u9762\u7684\u534f\u540c\u4f5c\u7528\u3002<\/p>\n

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\n \"\"
\n \uff08a\uff09\u94dc\u63ba\u6742\u5230MSNs\u8fc7\u7a0b\u4e2d\u7ed3\u6784\u53d8\u5316\u7684\u793a\u610f\u56fe\u3002
\n \uff08b\uff09Cu-HMSNs\u7684SEM\u56fe\u50cf\u3002
\n \uff08c\uff09SiO2<\/sub>\uff0cCu-HMSNs\u548cCuSiO3<\/sub>\u20223H2<\/sub>O\u7684XRD\u56fe\u8c31\u3002
\n \uff08d\uff09MSNs\u548cCu-HMSNs\u7684TEM\u56fe\u50cf\u548c\u76f8\u5e94\u533a\u57df\u7684\u7535\u5b50\u884d\u5c04\uff08ED\uff09\u56fe\u50cf\u3002
\n \uff08e\uff09\u6697\u573aTEM\u56fe\u50cf\u548cCu-HMSNs\u7684\u76f8\u5e94\u533a\u57df\u5143\u7d20mapping\u3002<\/p>\n

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\n \"\"
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\n \uff08c-d\uff09\u4e0d\u540cpH\u6761\u4ef6\u4e0b\uff08c\uff09Cu\u548c\uff08d\uff09Si\u7684\u91ca\u653e\u3002<\/p>\n

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\n \"\"
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\n \uff08b\uff09\u4e0d\u540c\u6761\u4ef6\u4e0b\u68c0\u6d4b\u5230\u7684ESR\u4fe1\u53f7\uff08H2<\/sub>O2<\/sub>\uff1bDSF@PEG\/Cu HMSNs+ H2<\/sub>O2<\/sub>\uff0cpH=7.4\uff1bDSF@PEG\/Cu HMSNs+ H2<\/sub>O2<\/sub>\uff0cpH=6.5\uff09\u3002
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\n \uff08g\uff094T1\u7ec6\u80de\u7ecfPEG\/Cu-HMSNs\u3001\u6e38\u79bbDSF\u3001CuET\u3001H2<\/sub>O2<\/sub>\uff08100 \u03bcM\uff09\u3001DSF@PEG\/Cu-HMSNs\u548cDSF@PEG\/Cu-HMSNs+ H2<\/sub>O2<\/sub>\uff08100 \u03bcM\uff09\u5b75\u80b224\u5c0f\u65f6\u540e\u7684CLSM\u56fe\u50cf\u548c\u7528FITC\u6807\u8bb0\u7684PEG\/Cu-HMSNs\u5b75\u80b24\u5c0f\u65f6\u76844T1\u7ec6\u80de\u7684CLSM\u56fe\u50cf\u3002
\n \uff08h\uff09\u7528\u6d41\u5f0f\u7ec6\u80de\u4eea\u5b9a\u91cf4T1\u7ec6\u80de\uff0c\u5305\u62ec\u4e0d\u540c\u5904\u7406\u540e\u6d3b\u7ec6\u80de\u3001\u65e9\u671f\u51cb\u4ea1\u7ec6\u80de\u548c\u665a\u671f\u51cb\u4ea1\u7ec6\u80de\u7684\u767e\u5206\u6bd4\u3002<\/p>\n

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\n \"\"
\n \uff08a\uff094T1\u80bf\u7624\u5f02\u79cd\u79fb\u690d\u5efa\u7acb\u548c\u6cbb\u7597\u8fc7\u7a0b\u793a\u610f\u56fe\u3002
\n \uff08b\uff09\u6ce8\u5c04PEG\/Cu-HMSNs\u540e\u6606\u660e\u9f20\u8840\u6db2\u4e2dSi\u7684\u4ee3\u8c22\u66f2\u7ebf\u3002
\n \uff08c\uff09\u4e0d\u540c\u65f6\u95f4\u70b9\u5fc3\u3001\u809d\u3001\u813e\u3001\u80ba\u3001\u80be\u548c\u80bf\u7624\u5185\u7684Si\u7684\u5206\u5e03\u3002
\n \uff08d\uff09\u4e0d\u540c\u6cbb\u7597\u7ec4\u5c0f\u9f20\u4f53\u91cd\u53d8\u5316\u3002
\n \uff08e\uff09\u4e0d\u540c\u6cbb\u7597\u7ec4\u5c0f\u9f20\u80bf\u7624\u4f53\u79ef\u53d8\u5316\u3002
\n \uff08f\uff09\u4e0d\u540c\u6cbb\u7597\u7ec415\u5929\u540e\u5207\u9664\u80bf\u7624\u7684\u7167\u7247\u3002
\n \uff08g\uff09\u4e0d\u540c\u6cbb\u7597\u7ec4\u80bf\u7624\u7684H&E\u3001TUNEL\u548cKi-67\u67d3\u8272\u5207\u7247\u56fe\u50cf\u3002<\/p>\n

\u3010\u603b\u7ed3\u5c55\u671b\u3011<\/strong><\/p>\n

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\u6587\u732e\u94fe\u63a5\uff1aEnhanced Tumor-Specific Disulfiram Chemotherapy by In Situ Cu2+ Chelation-Initiated Nontoxicity-to-Toxicity Transition<\/a> (J. Am. Chem. Soc.<\/em>, 2019<\/strong>, DOI: 10.1021\/jacs.9b03503)<\/p>\n

\u672c\u6587\u7531\u5927\u5175\u54e5\u4f9b\u7a3f\u3002<\/p>\n

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