{"id":181271,"date":"2019-07-26T06:30:14","date_gmt":"2019-07-25T22:30:14","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=181271"},"modified":"2019-07-25T14:06:29","modified_gmt":"2019-07-25T06:06:29","slug":"%e3%80%90%e5%b7%b2%e6%a0%a1%e7%a8%bf%e3%80%91nat-nanotechnol-gsh%e4%bb%8b%e5%af%bc%e7%9a%84%e7%94%9f%e7%89%a9%e8%bd%ac%e5%8c%96%e8%b0%83%e8%8a%82%e7%ba%b3%e7%b1%b3%e7%b2%92%e5%ad%90%e7%9a%84","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=181271","title":{"rendered":"Nat. Nanotechnol.: GSH\u4ecb\u5bfc\u7684\u751f\u7269\u8f6c\u5316\u8c03\u8282\u7eb3\u7c73\u7c92\u5b50\u7684\u4f53\u5185\u8f6c\u8fd0"},"content":{"rendered":"

\u3010\u7814\u7a76\u80cc\u666f\u3011<\/strong><\/p>\n

\u8c37\u80f1\u7518\u80bd\u4ecb\u5bfc\u7684\u809d\u5185\u751f\u7269\u8f6c\u5316\u662f\u4f17\u6240\u5468\u77e5\u7684\u89e3\u6bd2\u8fc7\u7a0b\u3002\u5bf9\u4e8e\u5de5\u7a0b\u7eb3\u7c73\u9897\u7c92\uff0c\u809d\u5185\u5355\u6838\u541e\u566c\u7ec6\u80de\u7cfb\u7edf\uff08MPS\uff09\u53ef\u4ee5\u7f29\u77ed\u5176\u8840\u6db2\u6ede\u7559\u65f6\u95f4\uff0c\u8bf1\u5bfc\u957f\u671f\u7eb3\u7c73\u6bd2\u6027\uff0c\u963b\u6b62\u75be\u75c5\u9776\u5411\uff0c\u964d\u4f4e\u4e34\u5e8a\u8f6c\u5316\u6f5c\u529b\u3002\u5bf9\u4e8e\u5c0f\u578b\u5916\u6e90\u6027\u7269\u8d28\uff0c\u809d\u810f\u89e3\u6bd2\u4f5c\u7528\u4e3b\u8981\u4f9d\u8d56\u8c37\u80f1\u7518\u80bd\uff08GSH\uff09\u4ecb\u5bfc\u7684\u751f\u7269\u8f6c\u5316\u3002GSH\u5728\u809d\u810f\u5185\u542b\u91cf\u8f83\u9ad8\uff08~10 mM\uff09\uff0c\u5b83\u7684\u4eb2\u6838\u534a\u80f1\u6c28\u9178\u6b8b\u57fa\u5bf9\u4eb2\u7535\u4ee3\u8c22\u7269\u6216\u91cd\u91d1\u5c5e\u5177\u6709\u9ad8\u5ea6\u53cd\u5e94\u6027\uff0c\u53ef\u4ee5\u964d\u4f4e\u5b83\u4eec\u7684\u6bd2\u6027\uff0c\u589e\u52a0\u5b83\u4eec\u7684\u4eb2\u6c34\u6027\uff0c\u5e76\u901a\u8fc7\u809d\u80c6\u9014\u5f84\u6216\u80be\u810f\u7cfb\u7edf\u6e05\u9664\u3002\u7136\u800c\uff0cGSH\u4ecb\u5bfc\u7684\u751f\u7269\u8f6c\u5316\u5982\u4f55\u5f71\u54cd\u7eb3\u7c73\u7c92\u5b50\u7684\u8840\u6db2\u6ede\u7559\u3001\u75be\u75c5\u9776\u5411\u548c\u4f53\u5185\u6e05\u9664\u4ecd\u7136\u662f\u672a\u77e5\u7684\uff0c\u5373\u4f7f\u8fd9\u4e00\u751f\u7406\u8fc7\u7a0b\u4e0d\u65ad\u5728\u4f53\u5185\u53d1\u751f\u3002\u4e0eMPS\u4ecb\u5bfc\u7684\u5de5\u7a0b\u7eb3\u7c73\u7c92\u5b50\u89e3\u6bd2\u76f8\u6bd4\uff0c\u4eba\u4eec\u5bf9GSH\u4ecb\u5bfc\u7684\u89e3\u6bd2\u8fc7\u7a0b\u77e5\u4e4b\u751a\u5c11\uff0c\u4e3b\u8981\u56e0\u4e3a\uff1a\uff081\uff09MPS\u4e0eGSH\u4ecb\u5bfc\u7684\u809d\u810f\u89e3\u6bd2\u4f5c\u7528\u5e38\u5e38\u96be\u4ee5\u533a\u522b\uff0c\u4f7f\u5f97\u5f88\u96be\u51c6\u786e\u5b9a\u4f4dGSH\u4ecb\u5bfc\u7684\u751f\u7269\u8f6c\u5316\u5728\u7eb3\u7c73\u9897\u7c92\u8f6c\u8fd0\u4e2d\u7684\u4f5c\u7528\uff1b\uff082\uff09\u7f3a\u4e4f\u7528\u4e8e\u809d\u810f\u4e2dGSH\u4ecb\u5bfc\u7684\u751f\u7269\u8f6c\u5316\u7684\u5b9e\u65f6\u975e\u4fb5\u5165\u6027\u76d1\u6d4b\u7684\u6210\u50cf\u6280\u672f\uff1b\uff083\uff09\u5728\u4f53\u5185\u751f\u7269\u8f6c\u5316\u540e\u56de\u6536\u5de5\u7a0b\u7eb3\u7c73\u7c92\u5b50\u8fdb\u884c\u8be6\u7ec6\u7684\u5316\u5b66\u5206\u6790\u975e\u5e38\u5177\u6709\u6311\u6218\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u671f\uff0c\u5fb7\u514b\u8428\u65af\u5927\u5b66\u8fbe\u62c9\u65af\u5206\u6821\u90d1\u6770\u6559\u6388\u548c\u848b\u5174\u57ad\u535a\u58eb\uff08\u7b2c\u4e00\u4f5c\u8005\uff09<\/strong>\u901a\u8fc7\u8bbe\u8ba1\u53ef\u4e0e\u8840\u6e05\u86cb\u767d\u7ed3\u5408\u5e76\u8f6c\u8fd0\u81f3\u809d\u810f\u7684\u786b\u9187\u53ef\u6fc0\u6d3b\u7684\u8367\u5149\u91d1\u7eb3\u7c73\u63a2\u9488ICG4<\/sub>-GS-Au25\uff08ICG\uff0c\u5432\u54da\u83c1\u7eff\uff1bGS-Au25\uff0cGSH\u5305\u88ab\u7684Au25\u7eb3\u7c73\u56e2\u7c07\uff09\uff0c\u4ee5\u9ad8\u7279\u5f02\u6027\u975e\u4fb5\u5165\u6027\u5730\u5728\u4f53\u5185\u6210\u50cf\u751f\u7269\u8f6c\u5316\u52a8\u529b\u5b66\uff0c\u5e76\u5728\u5316\u5b66\u6c34\u5e73\u4e0a\u68c0\u6d4b\u4e86\u8fd9\u4e00\u8fc7\u7a0b\u3002\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u809d\u7ec6\u80de\u7684GSH\u5916\u6392\u5bfc\u81f4\u809d\u7aa6\u4e2dGSH\u548c\u534a\u80f1\u6c28\u9178\uff08Cys\uff09\u7684\u5c40\u90e8\u5347\u9ad8\uff0c\u8fd9\u6539\u53d8\u4e86\u7eb3\u7c73\u9897\u7c92\u8868\u9762\u7684\u5316\u5b66\u6027\u8d28\uff0c\u964d\u4f4e\u4e86\u5176\u5bf9\u8840\u6e05\u86cb\u767d\u7684\u4eb2\u548c\u529b\uff0c\u5e76\u663e\u8457\u6539\u53d8\u4e86\u5176\u8840\u6db2\u6ede\u7559\u3001\u9776\u5411\u6027\u548c\u6e05\u9664\u6027\u3002\u901a\u8fc7\u8fd9\u79cd\u751f\u7269\u8f6c\u5316\uff0c\u809d\u810f\u7684\u89e3\u6bd2\u4f5c\u7528\uff0c\u8fd9\u4e2a\u957f\u671f\u4ee5\u6765\u88ab\u8ba4\u4e3a\u662f\u7eb3\u7c73\u836f\u7269\u8f6c\u5316\u7684\u963b\u788d\uff0c\u53ef\u4ee5\u6210\u4e3a\u63d0\u9ad8\u7eb3\u7c73\u836f\u7269\u7684\u9776\u5411\u548c\u964d\u4f4e\u7eb3\u7c73\u6bd2\u6027\u7684\u6865\u6881\u3002\u8be5\u6210\u679c\u8fd1\u65e5\u4ee5\u9898\u4e3a\u201cGlutathione-mediated biotransformation in the liver modulates nanoparticle transport<\/strong>\u201d\u53d1\u8868\u5728\u77e5\u540d\u671f\u520aNature Nanotechnology<\/strong>\u4e0a\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe\u4e00\uff1aICG4<\/sub>-GS-Au25\u4e0e\u809d\u7aa6\u5185GSH\u5916\u6392\u7684\u76f8\u4e92\u4f5c\u7528<\/strong>
\n \"\"
\n \uff08a\uff09\u809d\u7ec6\u80deGSH\u5916\u6392\u5230\u809d\u7aa6\u3002
\n \uff08b\uff09ICG4<\/sub>-GS-Au25\u5728\u809d\u5185\u7684\u4f5c\u7528\u8fc7\u7a0b\u53ca\u68c0\u6d4b\u673a\u7406\u3002<\/p>\n

\u56fe\u4e8c\uff1aICG-GS-Au25\u7eb3\u7c73\u63a2\u9488\u7684\u8868\u5f81<\/strong>
\n \"\"
\n \uff08a\uff09\u5def\u57fa\u53ef\u6d3b\u5316\u7684ICG-GS-Au25\u7eb3\u7c73\u63a2\u9488\u7684\u793a\u610f\u56fe\uff1a\u5f53ICG\u4e0eAu25\u4e0a\u7684GSH\u8fde\u63a5\u65f6\uff0cICG\u7684\u8367\u5149\u7531\u4e8e\u5149\u8bf1\u5bfc\u7684\u7535\u5b50\u8f6c\u79fb\u800c\u4e25\u91cd\u731d\u706d\uff0c\u4e00\u65e6ICG-GS\u914d\u4f53\u88ab\u751f\u7269\u786b\u9187\u5206\u5b50\u7f6e\u6362\u5e76\u4eceAu25\u8868\u9762\u5206\u79bb\uff0c\u7535\u5b50\u8f6c\u79fb\u8fc7\u7a0b\u5c31\u88ab\u7834\u574f\uff0c\u540c\u65f6\u6062\u590dICG\u7684NIR\u8367\u5149\u3002
\n \uff08b\uff09\u542b\u4e0d\u540c\u6570\u76eeICG [0.9 (1), 1.8 (2), 2.6 (3), 4.1 (4)]\u7684GS-Au25\u548c\u5355\u72ecICG\u7684\u5438\u6536\u66f2\u7ebf\u3002
\n \uff08c\uff09\u76f8\u540cICG\u6d53\u5ea6\u4e0b\uff0c\u5bf9\u5e94\uff08b\uff09\u4e2d\u6750\u6599\u7684\u7684\u8367\u5149\u8c31\u56fe\u3002
\n \uff08d\uff09\u6eb6\u89e3\u5728PBS\u4e2d\u7684\u6750\u65991-5\u7684\u5f69\u8272\u56fe\u50cf\uff08\u4e0a\u56fe\uff09\uff0c\u76f8\u5e94\u7684\u4f53\u5185\u6210\u50cfICG\u8367\u5149\u4fe1\u53f7\uff08\u4e2d\u95f4\uff09\uff0c\u5e95\u90e8\u4e3a\u76f8\u540c\u91cf\u7684\u6750\u65991-5\u7684\u8367\u5149\u4fe1\u53f7\u6eb6\u89e3\u5728\u542b\u670910mM GSH\u7684PBS\u4e2d\uff08pH\u8c03\u8282\u81f37.4\uff09\u3002
\n \uff08e\uff09GS-Au25\u548cGS-Au25 ICG\u6750\u6599\u7684\u8840\u6e05\u86cb\u767d\u7ed3\u5408\u767e\u5206\u6bd4\u3002
\n \uff08f\uff09\u5c06ICG4<\/sub>-GS-Au25\u5728PBS\u621650\uff05FBS\u4e2d\u4e0e\u4e0d\u540c\u6d53\u5ea6\u7684GSH\uff08pH\u8c03\u8282\u81f37.4\uff09\u572837\u2103 \u5b75\u80b210\u5206\u949f\u540eICG\u8367\u5149\u6062\u590d\u7684\u767e\u5206\u6bd4\u3002<\/p>\n

\u56fe\u4e09\uff1a\u809d\u7ec6\u80deGSH\u91ca\u653e\u5bf9ICG4<\/sub>-GS-Au25\u4f53\u5185\u884c\u4e3a\u7684\u5f71\u54cd<\/strong>
\n \"\"
\n \uff08a\uff09BALB\/c\u5c0f\u9f20\u9759\u8109\u6ce8\u5c04GS-Au25\u548cICG4<\/sub>-GS-Au25 (n=3)\u7684\u80be\u810f\u6e05\u9664\u52a8\u529b\u5b66\u3002
\n \uff08b\uff09(i)\u9759\u8109\u6ce8\u5c04GS-Au25\u548cICG4<\/sub>-GS-Au25\uff08n=3\uff09\u7684\u836f\u4ee3\u52a8\u529b\u5b66\uff1b(ii) GS-Au25\u548cICG4-GS-Au25\uff08n=3\uff09\u836f\u4ee3\u52a8\u529b\u5b66\u6d4b\u91cf\u5f97\u5230\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u66f2\u7ebf\u4e0b\u9762\u79ef(AUC)\u548c\u6e05\u9664\u53c2\u6570\u3002
\n \uff08c\uff09\u9759\u8109\u6ce8\u5c04ICG4<\/sub>-GS-Au25\uff08n=3\uff09\u540e24\u5c0f\u65f6\uff0c\u5c3f\u6db2\u548c\u7caa\u4fbf\u4e2d\u7684ICG\u548cAu\u6e05\u9664\u7387\u3002
\n \uff08d\uff09\u9759\u8109\u6ce8\u5c04ICG4<\/sub>-GS-Au25\u7684PBS\u5904\u7406\uff08\u5bf9\u7167\u7ec4\uff09\u548cDEM\u5904\u7406\u5c0f\u9f20\u7684\u65f6\u95f4\u5e8f\u5217\u65e0\u521b\u8367\u5149\u6210\u50cf\u3002
\n \uff08e\uff09\u5728\u9759\u8109\u5185\u6ce8\u5c04\u76f8\u540c\u7684ICG4<\/sub>-GS-Au25\u540e\u7684\u524d5\u5206\u949f\uff0cPBS\u5904\u7406\u5c0f\u9f20\u548cDEM\u5904\u7406\u5c0f\u9f20\uff08n=3\uff09\u7684\u809d\u5185ICG\u8367\u5149\u52a8\u529b\u5b66\u3002
\n \uff08f\uff09\u9759\u8109\u6ce8\u5c04ICG4<\/sub>-GS-Au25\u540ePBS\u5904\u7406\u5c0f\u9f20\u548cDEM\u5904\u7406\u5c0f\u9f20\uff08n=3\uff09\u4e2d\u6bcf\u4e2a\u5faa\u73afAu25\u7684ICG\u5206\u5b50\u5e73\u5747\u6570\u3002
\n \uff08g\uff09\u5728\u9759\u8109\u5185\u6ce8\u5c04\u76f8\u540c\u7684ICG4<\/sub>-GS-Au25\u540e\uff0cPBS\u5904\u7406\u548cDEM\u5904\u7406\u5c0f\u9f20\uff08n=3\uff09\u7684\u524d2\u5c0f\u65f6Au\u836f\u4ee3\u52a8\u529b\u5b66\u3002
\n \uff08h\uff09\u9759\u8109\u6ce8\u5c04ICG4<\/sub>-GS-Au25\u540e10\u5206\u949f\u548c24\u5c0f\u65f6\u6b63\u5e38\u5c0f\u9f20\u809d\u7ec4\u7ec7\u5207\u7247\u7684\u8367\u5149\u6210\u50cf\u3002
\n \uff08i\uff09\u4ece\u9759\u8109\u6ce8\u5c04ICG4<\/sub>-GS-Au25\u7684PBS\u5904\u7406\u5c0f\u9f20\u548cDEM\u5904\u7406\uff08n=3\uff09\u5c0f\u9f20\u5c3f\u6db2\u4e2d\u6392\u6cc4\u7684Au\u7eb3\u7c73\u56e2\u7c07\u7684\u5438\u6536\u66f2\u7ebf\u3002<\/p>\n

\u56fe\u56db\uff1a\u4f53\u5185\u751f\u7269\u8f6c\u5316\u540eAu25\u8868\u9762\u5316\u5b66\u5206\u6790<\/strong>
\n \"\"
\n \uff08a\uff09\u7528\u4e8e\u5206\u6790\u751f\u7269\u8f6c\u5316\u540eAu25\u8868\u9762\u914d\u4f53\u7684\u4e24\u76f8\u914d\u4f53\u4ea4\u6362\u6cd5\u7684\u793a\u610f\u56fe\u3002
\n \uff08b\uff09HPLC\u7ed3\u679c\u8868\u660eAu25\u7684\u8868\u9762\u914d\u4f53\u5728\u6ce8\u5c04ICG4-GS-Au25\u7684\u5c0f\u9f20\u7684\u5c3f\u6db2\u4e2d\u6392\u6cc4\uff08n=3\uff09\u3002
\n \uff08c\uff09\uff08i\uff09GS-Au25\u8868\u9762\u914d\u4f53(Au25(SG)18)\u4f53\u591637\u2103\u57f9\u517b10 min\uff0c\u4f53\u5185\u5faa\u73af10 min\uff0c\u53cc\u80be\u52a8\u8109\u6682\u65f6\u5939\u4f4f\uff0c\u4ee5\u9632\u6b62GS-Au25\u80be\u810f\u5feb\u901f\u6e05\u9664\uff0c\u4f53\u5916\u57f9\u517b10 min\u540e\u7684HPLC\u7ed3\u679c\uff1b\uff08ii\uff09\u4f53\u5916\u5b75\u80b2\u6216\u4f53\u5185\u5faa\u73af10 min\u540e\u6bcf\u4e2aAu25\u8868\u9762\u4e0a\u7684Cys\u914d\u4f53\u7684\u5e73\u5747\u6570\u76ee\uff08n=3\uff09\u3002
\n \uff08d\uff09\u9759\u8109\u6ce8\u5c04ICG4<\/sub>-GS-Au25\u540e10 min\u6b63\u5e38\u5c0f\u9f20H\uff06E\u67d3\u8272\u7684\u80be\u7ec4\u7ec7\u7684\u8367\u5149\u6210\u50cf\u3002<\/p>\n

\u56fe\u4e94\uff1aICG4-GS-Au25\u7684\u80bf\u7624\u9776\u5411\u7814\u7a76<\/strong>
\n \"\"
\n \uff08a\uff09\u4ee5Au\uff08i\uff09\u548cICG\uff08ii\uff09\u5bf9\u6bd4\u6ce8\u5c0424\u5c0f\u65f6\u7684ICG4<\/sub>-GS-Au25\u4e0eGS-Au25\u548c\u6e38\u79bbICG\u5bf9MCF-7\u7ec6\u80de\u7684\u9776\u5411\u6548\u7387\uff08n=3\uff09\u3002
\n \uff08b\uff09\u9759\u8109\u6ce8\u5c04\u6e38\u79bbICG\u548cICG4<\/sub>-GS-Au25\uff08n=3\uff09\u7684\u5c0f\u9f20\u8840\u6db2\u4e2dICG\u836f\u4ee3\u52a8\u529b\u5b66\u7684\u5bf9\u6bd4\u3002
\n \uff08c\uff09\u9759\u8109\u6ce8\u5c04ICG4<\/sub>-GS-Au25\u6216\u7b49\u91cf\u7684\u6e38\u79bbICG\u540e\uff0c\u5728\u4e0d\u540c\u65f6\u95f4\u70b9 MCF-7\u8377\u7624\u5c0f\u9f20\u7684\u8367\u5149\u56fe\u50cf\u3002
\n \uff08d\uff09\u9759\u8109\u6ce8\u5c04ICG4<\/sub>-GS-Au25\u548c\u6e38\u79bbICG\uff08n=3\uff09\u540e\uff0c\u65f6\u95f4\u4f9d\u8d56\u6027\u5c0f\u9f20\u80bf\u7624\u5bf9\u6bd4\u6307\u6570\u3002
\n \uff08e\uff09ICG4<\/sub>-GS-Au25\u548c\u6e38\u79bbICG\uff08n=3\uff09\u7684\u65f6\u95f4\u4f9d\u8d56\u6027\u80bf\u7624\u8367\u5149\u5f3a\u5ea6\u3002
\n \uff08f\uff09\u5de6\uff1a\u5728\u9759\u8109\u5185\u6ce8\u5c04ICG4<\/sub>-GS-Au25\u540e15 min\uff0c\u5c06\u5c0f\u9f20\u5b89\u4e50\u6b7b\u5e76\u7528PBS\u5f7b\u5e95\u704c\u6ce8\u4ee5\u9664\u53bb\u8840\u7ba1\u4e2d\u7684ICG-Au25\u7ed3\u5408\u7269\uff0c\u7136\u540e\u5207\u9664\u80bf\u7624\u5e76\u7624\u5185\u6ce8\u5c04GSH\uff0810 mM, pH7.4\uff09\u4ee5\u8bf1\u5bfcICG-Au25\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u89e3\u79bb\u3002
\n \u53f3\uff1a\u5728\u6ce8\u5c04GSH\u4e4b\u524d\u548c\u4e4b\u540e\u7684\u80bf\u7624ICG\u8367\u5149\u5f3a\u5ea6\uff08n=3\uff09\u3002
\n \uff08g\uff09\u9759\u8109\u6ce8\u5c04ICG4<\/sub>-GS-Au25\u540e24\u5c0f\u65f6H\uff06E\u67d3\u8272\u80bf\u7624\u7ec4\u7ec7\u7684\u8367\u5149\u6210\u50cf\u3002<\/p>\n

\u56fe\u516d\uff1a\u809d\u5185GSH\u4ecb\u5bfc\u7684\u751f\u7269\u8f6c\u5316\u5f71\u54cdICG4-GS-Au25\u7684\u4f53\u5185\u8f6c\u8fd0<\/strong>
\n \"\"
\n \u9759\u8109\u5185\u7ed9\u836f\u540e\uff0cICG4<\/sub>-GS-Au25\u7eb3\u7c73\u56e2\u7c07\u7acb\u5373\u4e0e\u8840\u6e05\u86cb\u767d\u7ed3\u5408\u3002\u8840\u6e05\u86cb\u767d\u7ed3\u5408\u7684ICG4<\/sub>-GS-Au25\u7684\u6574\u4f53\u5c3a\u5bf8\u5927\u4e8e\u80be\u810f\u8fc7\u6ee4\u9608\u503c\uff0c\u56e0\u6b64\u53ef\u4ee5\u9632\u6b62\u5feb\u901f\u80be\u810f\u6d88\u9664\uff0c\u5e76\u90e8\u5206\u8f6c\u8fd0\u5230\u809d\u7aa6\u3002\u7531\u4e8e\u809d\u7aa6\u5904\u5c40\u90e8\u9ad8\u6d53\u5ea6\u7684GSH\u548c\u534a\u80f1\u6c28\u9178 \u4f7f\u90e8\u5206\u6216\u5168\u90e8\u7684ICG-GS\u4eceAu25\u8868\u9762\u7f6e\u6362\u8131\u79bb\uff0c\u964d\u4f4e\u4e86ICG4<\/sub>-GS-Au25\u7684\u86cb\u767d\u7ed3\u5408\u4eb2\u548c\u529b\u3002\u88ab\u7f6e\u6362\u7684ICG-GS\u88ab\u809d\u7ec6\u80de\u6444\u53d6\u5e76\u901a\u8fc7\u809d\u80c6\u9014\u5f84\u6e05\u9664\uff0c\u800c\u751f\u7269\u8f6c\u5316\u7684ICG-GS-Au25\u7eb3\u7c73\u56e2\u7c07\u88ab\u8f6c\u8fd0\u56de\u8840\u6db2\u5faa\u73af\u5e76\u901a\u8fc7EPR\u6548\u5e94\u9776\u5411\u80bf\u7624\u7ec4\u7ec7\u3002\u5f53\u751f\u7269\u8f6c\u5316\u7684ICG-GS-Au25\u7eb3\u7c73\u56e2\u7c07\u5faa\u73af\u5230\u80be\u810f\u65f6\uff0c\u5bf9\u8840\u6e05\u86cb\u767d\u5177\u6709\u4f4e\u4eb2\u548c\u529b\u7684\u7eb3\u7c73\u9897\u7c92\u901a\u8fc7\u80be\u5c0f\u7403\u8fc7\u6ee4\u5e76\u5728\u80be\u8fd1\u7aef\u5c0f\u7ba1\u4e2d\u8fdb\u884c\u989d\u5916\u7684\u8868\u9762\u4fee\u9970\uff0c\u5176\u4e2dAu25\u7eb3\u7c73\u56e2\u7c07\u4e0a\u5269\u4f59\u7684ICG-GS\u88ab\u534a\u80f1\u6c28\u9170\u7518\u6c28\u9178\u8fdb\u4e00\u6b65\u53d6\u4ee3\uff0c\u8fd1\u7aef\u5c0f\u7ba1\u4e2dGSH\u7684\u7ec6\u80de\u5916\u4ee3\u8c22\u4ea7\u7269\u3002\u5bf9\u4e8e\u4ecd\u7136\u4e0e\u8840\u6e05\u86cb\u767d\u7ed3\u5408\u7684\u751f\u7269\u8f6c\u5316\u7684ICG-GS-Au25\uff0c\u5b83\u4eec\u4fdd\u7559\u5728\u8840\u6d41\u4e2d\u5e76\u7ee7\u7eed\u9776\u5411\u80bf\u7624\u3002\u5728\u80bf\u7624\u4e2d\uff0cICG4<\/sub>-GS-Au25\u53ca\u5176\u751f\u7269\u8f6c\u5316\u7684\u884d\u751f\u7269\u8fdb\u5165\u80bf\u7624\u5fae\u73af\u5883\u5e76\u88ab\u80bf\u7624\u7ec6\u80de\u6444\u53d6\u3002\u9ad8\u6d53\u5ea6\u7684\u80de\u5185GSH\u8bf1\u5bfcICG-GS\u4ece\u7ec6\u80de\u5185\u7684Au25\u89e3\u79bb\u5e76\u6301\u7eed\u53d1\u5149\u3002<\/p>\n

\u3010\u603b\u7ed3\u5c55\u671b\u3011<\/p>\n

\u4f5c\u4e3a\u4f17\u6240\u5468\u77e5\u7684\u89e3\u6bd2\u8fc7\u7a0b\uff0c\u809d\u810f\u5185GSH\u4ecb\u5bfc\u7684\u751f\u7269\u8f6c\u5316\uff0c\u53ef\u7528\u4e8e\u8c03\u8282\u7eb3\u7c73\u9897\u7c92\u7684\u4f53\u5185\u8fd0\u8f93\uff0c\u4ee5\u63d0\u9ad8\u7eb3\u7c73\u7c92\u5b50\u7684\u75be\u75c5\u9776\u5411\u540c\u65f6\u51cf\u5c11\u5728\u5065\u5eb7\u7ec4\u7ec7\u4e2d\u7684\u975e\u7279\u5f02\u6027\u79ef\u7d2f\uff0c \u964d\u4f4e\u201c\u8131\u9776\u201d\u7eb3\u7c73\u7c92\u5b50\u7684\u5371\u5bb3\u3002\u6b64\u5916\uff0c\u8fd9\u79cd\u5bf9\u7eb3\u7c73\u7c92\u5b50\u7684\u5316\u5b66\u6c34\u5e73\u548c\u4f53\u5185\u8f6c\u8fd0\u7684\u7eb3\u7c73\u751f\u7269\u76f8\u4e92\u4f5c\u7528\u7684\u57fa\u672c\u7406\u89e3\u5c06\u8fdb\u4e00\u6b65\u63a8\u8fdb\u7eb3\u7c73\u751f\u7406\u5b66\u548c\u6bd2\u7406\u5b66\uff0c\u4e3a\u7eb3\u7c73\u836f\u7269\u7684\u4e34\u5e8a\u8f6c\u5316\u5f00\u8f9f\u4e86\u66f4\u591a\u7684\u673a\u4f1a\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aGlutathione-mediated biotransformation in the liver modulates nanoparticle transport<\/a> (Nature Nanotechnology<\/em>, 2019<\/strong>, DOI: 10.1038\/s41565-019-0499-6)<\/p>\n

\u7814\u7a76\u56e2\u961f\u7b80\u4ecb<\/strong>
\n \"\"
\n \u90d1\u6770\u535a\u58eb\uff0c\u5fb7\u514b\u8428\u65af\u5927\u5b66\u8fbe\u62c9\u65af\u5206\u6821\u5316\u5b66\u4e0e\u751f\u7269\u5316\u5b66\u7cfb\u7ec8\u8eab\u6559\u6388\uff0c\u5fb7\u514b\u8428\u65af\u5927\u5b66\u897f\u5357\u533b\u5b66\u4e2d\u5fc3\u6ccc\u5c3f\u79d1\u517c\u804c\u6559\u6388\u3002\u4e3b\u8981\u7814\u7a76\u65b9\u5411\u4e3a\u7eb3\u7c73\u751f\u7269\u533b\u5b66\uff0c\u7eb3\u7c73\u6750\u6599\u4e0e\u751f\u7269\u4f53\u7684\u76f8\u4e92\u4f5c\u7528\u548c\u751f\u7269\u6210\u50cf\u7b49\u3002\u8fc4\u4eca\u5df2\u5728Nature nanotechnology\uff0cNature reviews materials\uff0c JACS\uff0c Angew Chem Int Ed\uff0cACS Nano\u7b49\u9ad8\u6c34\u5e73\u671f\u520a\u4f5c\u4e3a\u901a\u8baf\u4f5c\u8005\u53d1\u8868\u8bba\u658740\u4f59\u7bc7\u3002<\/strong><\/p>\n

\u8bfe\u9898\u7ec4\u7f51\u9875\uff1ahttps:\/\/www.utdallas.edu\/~jiezheng\/<\/a><\/strong><\/p>\n

\u6b22\u8fce\u611f\u5174\u8da3\u7684\u7814\u7a76\u751f\u548c\u535a\u58eb\u540e\u52a0\u5165\u56e2\u961f\u3002<\/strong><\/p>\n

\u672c\u6587\u7531\u5927\u5175\u54e5\u4f9b\u7a3f\u3002<\/p>\n

\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1\uff1atougao@cailiaoren.com<\/a><\/p>\n

\u6295\u7a3f\u4ee5\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1acailiaokefu<\/p>\n","protected":false},"excerpt":{"rendered":"

\u3010\u7814\u7a76\u80cc\u666f\u3011 \u8c37\u80f1\u7518\u80bd\u4ecb\u5bfc\u7684\u809d\u5185\u751f\u7269\u8f6c\u5316\u662f\u4f17\u6240\u5468\u77e5\u7684\u89e3\u6bd2\u8fc7\u7a0b\u3002\u5bf9\u4e8e\u5de5\u7a0b\u7eb3\u7c73\u9897\u7c92\uff0c\u809d\u5185\u5355\u6838\u541e\u566c\u7ec6\u80de\u7cfb\u7edf\uff08MPS\uff09\u53ef\u4ee5\u7f29\u77ed\u5176\u8840\u6db2\u6ede\u7559\u65f6\u95f4\uff0c\u8bf1\u5bfc\u957f\u671f\u7eb3\u7c73\u6bd2\u6027\uff0c\u963b\u6b62\u75be\u75c5…<\/p>\n","protected":false},"author":1004,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215],"tags":[4117],"class_list":["post-181271","post","type-post","status-publish","format-standard","hentry","category-jiedu","tag-gsh"],"_links":{"self":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/181271"}],"collection":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/users\/1004"}],"replies":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=181271"}],"version-history":[{"count":3,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/181271\/revisions"}],"predecessor-version":[{"id":181544,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/181271\/revisions\/181544"}],"wp:attachment":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=181271"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=181271"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=181271"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}