{"id":181754,"date":"2019-07-29T06:30:59","date_gmt":"2019-07-28T22:30:59","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=181754"},"modified":"2019-07-28T21:56:27","modified_gmt":"2019-07-28T13:56:27","slug":"%e5%b7%b2%e6%a0%a1%e7%a8%bf%e4%bb%b6-afm-%e6%8a%a5%e9%81%93-%e7%83%ad%e5%93%8d%e5%ba%94%e5%8d%8a%e5%af%bc%e4%bd%93%e8%81%9a%e5%90%88%e7%89%a9%e7%ba%b3%e7%b1%b3%e9%a2%97%e7%b2%92%e7%94%a8%e4%ba%8e","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=181754","title":{"rendered":"AFM \u62a5\u9053: \u70ed\u54cd\u5e94\u534a\u5bfc\u4f53\u805a\u5408\u7269\u7eb3\u7c73\u9897\u7c92\u7528\u4e8e\u5bf9\u6bd4\u589e\u5f3a\u5149\u58f0\u6210\u50cf"},"content":{"rendered":"

\u3010\u80cc\u666f\u4ecb\u7ecd\u3011<\/strong><\/p>\n

\u5149\u58f0\uff08photoacoustic, PA\uff09\u6210\u50cf\u662f\u4e00\u79cd\u68c0\u6d4b\u5149\u80fd\u8f6c\u6362\u4e3a\u8d85\u58f0\u6ce2\u7684\u6df7\u5408\u578b\u975e\u7535\u79bb\u6210\u50cf\u6280\u672f\u3002\u8d85\u58f0\u6ce2\u5728\u7a7f\u8fc7\u7ec4\u7ec7\u65f6\u6563\u5c04\u6bd4\u5149\u66f4\u5c11\uff0c\u6240\u4ee5PA\u6210\u50cf\u5177\u6709\u66f4\u6df1\u7684\u7ec4\u7ec7\u7a7f\u900f\u6df1\u5ea6\u3002\u5728\u6210\u50cf\u8fc7\u7a0b\u4e2d\uff0c\u7ec4\u7ec7\u5f80\u5f80\u4f1a\u4ea7\u751f\u80cc\u666f\u4fe1\u53f7\uff0c\u56e0\u6b64\u9700\u8981\u901a\u8fc7\u5206\u5b50\u8bbe\u8ba1\u7b56\u7565\u6765\u63d0\u9ad8PA\u6210\u50cf\u7684\u4fe1\u566a\u6bd4\uff08signal-to-background ratios, SBRs\uff09\u3002\u867d\u7136\u4e00\u4e9b\u54cd\u5e94\u6027\u7684PA\u63a2\u9488\u5df2\u7ecf\u88ab\u5f00\u53d1\uff0c\u4f46\u662f\u8fd9\u4e9b\u63a2\u9488\u7684SBRs\u5f88\u5927\u7a0b\u5ea6\u4e0a\u4f9d\u8d56\u4e8e\u75be\u75c5\u7ec4\u7ec7\u548c\u6b63\u5e38\u7ec4\u7ec7\u95f4\u7684\u5185\u6e90\u6027\u751f\u7269\u6807\u8bb0\u7269\u7684\u6d53\u5ea6\u5dee\u5f02\u3002\u76f8\u6bd4\u8f83\u800c\u8a00\uff0c\u5916\u90e8\u523a\u6fc0\u53ef\u4ee5\u901a\u8fc7\u624b\u52a8\u64cd\u4f5c\u7684\u65b9\u5f0f\u6765\u65e0\u521b\u6027\u5730\u63a7\u5236PA\u9020\u5f71\u5242\u7684\u4fe1\u53f7\u751f\u6210\uff0c\u56e0\u6b64\u589e\u5f3a\u6210\u50cf\u7075\u654f\u5ea6\u3002\u4f46\u662f\u5916\u90e8\u523a\u6fc0\u54cd\u5e94\u6027\u7684\u9020\u5f71\u5242\u5f88\u5c11\u88ab\u7528\u4e8ePA\u6210\u50cf\u3002\u7531\u4e8e\u5177\u6709\u826f\u597d\u7684\u5149\u5b66\u6027\u8d28\u548c\u751f\u7269\u76f8\u5bb9\u6027\uff0c\u6709\u673a\u534a\u5bfc\u4f53\u805a\u5408\u7269\u7eb3\u7c73\u9897\u7c92\uff08semiconducting polymer nanoparticles, SPNs\uff09\u4f5c\u4e3a\u4e00\u7c7b\u65b0\u5174\u7684\u5149\u8bca\u7597\u5242\u88ab\u5e7f\u6cdb\u5173\u6ce8\u3002\u76ee\u524d\uff0c\u57fa\u4e8eSPNs\u7684\u9020\u5f71\u5242\u5df2\u88ab\u5e7f\u6cdb\u7528\u4e8e\u751f\u7269\u7cfb\u7edf\u7684PA\u6210\u50cf\uff0c\u4f46\u662f\u5916\u90e8\u523a\u6fc0\u54cd\u5e94\u6027\u7684SPNs\u9020\u5f71\u5242\u7528\u4e8ePA\u6210\u50cf\u5f88\u5c11\u88ab\u5f00\u53d1\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u5357\u6d0b\u7406\u5de5\u5927\u5b66\u7684\u6d66\u4f83\u88d4\u548c\u6b66\u6c49\u5927\u5b66\u4e2d\u5357\u533b\u9662\u7684\u55bb\u7231\u559c\u548c\u80e1\u7965\uff08\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u8054\u5408\u62a5\u9053\u4e86\u4e00\u79cd\u7528\u4e8e\u80bf\u7624PA\u6210\u50cf\u7684\u70ed\u54cd\u5e94SPNs\u3002\u8fd9\u4e9bPA\u9020\u5f71\u5242\u7531\u805a\uff08N,N-\u4e8c\u7532\u57fa\u4e19\u70ef\u9170\u80fa\uff09-r-\uff08\u4e19\u70ef\u9178\u7f9f\u4e19\u916f\uff09\uff08PDMA-r-HPA\uff09\u4fee\u9970\u7684\u534a\u5bfc\u4f53\u805a\u5408\u7269\u81ea\u7ec4\u88c5\u800c\u6210\u3002PDMA-r-HPA\u5177\u6709\u70ed\u54cd\u5e94\u6027\uff0c\u53ef\u4ee5\u54cd\u5e94\u73af\u5883\u6e29\u5ea6\u7684\u53d8\u5316\u800c\u53d1\u751f\u53ef\u9006\u7684\u76f8\u53d8\u3002\u56e0\u6b64\uff0c\u5236\u5907\u7684SPNs\uff08SPNph1\u548cSPNph2\uff09\u5177\u6709\u8f83\u4f4e\u7684\u4e34\u754c\u6eb6\u89e3\u6e29\u5ea6\uff08LCSTs\uff09\uff0c\u5f53\u9ad8\u4e8e\u8be5\u6e29\u5ea6\u65f6\u76f8\u5206\u79bb\u53d1\u751f\uff0c\u4ece\u800c\u5f15\u8d77\u8fd9\u4e9b\u7eb3\u7c73\u9897\u7c92\u7684\u805a\u96c6\u3002\u968f\u7740\u5c3a\u5bf8\u7684\u589e\u5927\uff0c\u6563\u70ed\u91cf\u589e\u5927\uff0c\u9020\u5f71\u5242\u7684PA\u4fe1\u53f7\u653e\u5927\u3002\u56e0\u6b64\uff0c\u901a\u8fc7\u5347\u6e29\u53ef\u4ee5\u589e\u5f3a\u70ed\u54cd\u5e94SPNs\u7684PA\u4fe1\u53f7\uff0c\u4ece\u800c\u63d0\u4f9b\u4e86\u4e00\u79cd\u8fdc\u7a0b\u589e\u5f3aPA\u6210\u50cfSBRs\u7684\u65b9\u6cd5\u3002\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a\u201cThermoresponsive Semiconducting Polymer Nanoparticles for Contrast-Enhanced Photoacoustic Imaging\u201d<\/strong>\u53d1\u5e03\u5728\u56fd\u9645\u8457\u540d\u671f\u520aAdv. Funct. Mater.<\/strong>\u4e0a\u3002<\/p>\n

\u3010\u56fe\u6587\u89e3\u8bfb\u3011<\/strong><\/p>\n

\u56fe\u4e00\u3001\u6750\u6599\u7684\u5236\u5907\u4e0e\u4f5c\u7528\u793a\u610f\u56fe<\/strong>
\n \"\"
\n \uff08a\uff09 \u70ed\u54cd\u5e94\u6027\u805a\u5408\u7269\uff086\u548c7\uff09\u548c\u5bf9\u7167\u805a\u5408\u7269\uff085\uff09\u7684\u5408\u6210\u8def\u7ebf\uff0c\u4ee5\u53ca\u805a\u5408\u7269\u7684\u81ea\u7ec4\u88c5\u5f62\u6210\u7eb3\u7c73\u9897\u7c92\uff08SPNph1\u3001SPNph2\u548cSPNp\uff09\u3002<\/p>\n

\uff08b\uff09 \u70ed\u54cd\u5e94\u6027\u7eb3\u7c73\u9897\u7c92\u7684\u70ed\u523a\u6fc0\u5f15\u8d77\u7684PA\u4fe1\u53f7\u589e\u5f3a\u7684\u793a\u610f\u56fe\u3002<\/p>\n

\u56fe\u4e8c\u3001\u4f53\u5916\u8868\u5f81<\/strong>
\n \"\"\uff08a-b\uff09SPNs\u7684\u7d2b\u5916-\u53ef\u89c1\u5438\u6536\u548c\u8367\u5149\u5149\u8c31\uff1b<\/p>\n

\uff08c\uff09SPNs\u5728\u4e0d\u540c\u6e29\u5ea6\u4e0b\u7684\u5c3a\u5bf8\u53d8\u5316\uff08pH = 7.4\uff09\uff1b<\/p>\n

\uff08d\uff09\u572825\u621650\u2103\u6e29\u80b2\u540e\uff0cSPNph1\u548cSPNp\u7684TEM\u56fe\u50cf\uff1b<\/p>\n

\uff08d\uff09\u572825\u621650\u2103\u6e29\u80b2\u540e\uff0cSPNph1\u548cSPNp\u7684\u03b6-\u7535\u4f4d\uff1b<\/p>\n

\uff08f\uff09\u4e0d\u540c\u6d53\u5ea6\u7684SPNph1\u6216SPNp\u5904\u7406\u540e4T1\u7ec6\u80de\u7684\u7ec6\u80de\u5b58\u6d3b\u7387\u3002<\/p>\n

\u56fe\u4e09\u3001SPNph1\u548cSPNp\u7684\u4f53\u5916\u5149\u70ed\u548cPA\u8868\u5f81<\/strong>
\n \"\"\uff08a\uff09SPNph1\u548cSPNp\u6eb6\u6db2\u7684\u5149\u70ed\u6e29\u5ea6\u4e0e\u6fc0\u5149\u7167\u5c04\u65f6\u95f4\u7684\u51fd\u6570\u5173\u7cfb\uff1b<\/p>\n

\uff08b\uff09SPNph1\u548cSPNp\u5728\u5404\u81ea\u7684\u6700\u9ad8\u6e29\u5ea6\u4e0b\u7684\u70ed\u56fe\u50cf\uff1b<\/p>\n

\uff08c\uff09SPNph1\u548cSPNp\u7684\u5149\u70ed\u7a33\u5b9a\u6027\u7814\u7a76\uff1b<\/p>\n

\uff08d\uff09\u4e0d\u540c\u6e29\u5ea6\u4e0bSPNph1\u548cSPNp\u6eb6\u6db2\u7684PA\u4fe1\u53f7\u5f3a\u5ea6\uff1b<\/p>\n

\uff08e\uff09\u5728\u6709\uff08\u65e0\uff09\u6fc0\u5149\u7167\u5c04\u4e0b\uff0c\u4e0d\u540c\u6d53\u5ea6\u7684SPNph1\u548cSPNp\u6eb6\u6db2\u7684PA\u6210\u50cf\u56fe\u50cf\uff1b<\/p>\n

\uff08f-g\uff09\u5728\u6709\uff08\u65e0\uff09\u6fc0\u5149\u7167\u5c04\u4e0b\uff0c\u4e0d\u540c\u6d53\u5ea6\u7684SPNph1\u548cSPNp\u6eb6\u6db2\u7684PA\u4fe1\u53f7\u5f3a\u5ea6\u3002<\/p>\n

\u56fe\u56db\u3001\u4f53\u5185PA\u6210\u50cf<\/strong>
\n \"\"\uff08a\uff09\u5728\u6709\uff08\u65e0\uff09\u6fc0\u5149\u7167\u5c04\u7684\u60c5\u51b5\u4e0b\uff0c\u5c3e\u9759\u8109\u6ce8\u5c04SPNph1\u6216SPNp\u540e24 h\u6d3b\u4f53\u5c0f\u9f20\u80bf\u7624\u7684PA\u6210\u50cf\u56fe\u50cf\uff1b<\/p>\n

\uff08b\uff09\u5c3e\u9759\u8109\u6ce8\u5c04SPNph1\u6216SPNp\u540e32 h\uff0c\u5c0f\u9f20\u7684\u4e3b\u8981\u5668\u5b98\u548c\u80bf\u7624\u7684PA\u4fe1\u53f7\u5f3a\u5ea6\uff1b<\/p>\n

\uff08c\uff09\u5c3e\u9759\u8109\u6ce8\u5c04SPNph1\u540e\uff0c\u5149\u7167\u5f15\u8d77\u5c0f\u9f20\u80bf\u7624\u90e8\u4f4dPA\u4fe1\u53f7\u589e\u5f3a\u7684\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08d\uff09\u5728\u6709\uff08\u65e0\uff09\u6fc0\u5149\u7167\u5c04\u7684\u60c5\u51b5\u4e0b\uff0c\u5c3e\u9759\u8109\u6ce8\u5c04SPNp\u6216SPNph1\u540e\u5c0f\u9f20\u80bf\u7624\u90e8\u5206\u7684PA\u4fe1\u53f7\u5f3a\u5ea6\u3002<\/p>\n

\u3010\u603b\u7ed3\u3011<\/strong><\/p>\n

\u7efc\u4e0a\u6240\u8ff0\uff0c\u4f5c\u8005\u6210\u529f\u5236\u5907\u4e86\u53ef\u4ee5\u81ea\u7ec4\u88c5\u5f62\u6210\u70ed\u54cd\u5e94\u6027PA\u9020\u5f71\u5242\uff08SPNph1\uff09\u7684PDMA-r-HPA\u4fee\u9970\u7684\u534a\u5bfc\u4f53\u805a\u5408\u7269\uff0c\u7528\u4e8e\u5bf9\u6bd4\u589e\u5f3a\u7684\u4f53\u5185\u6210\u50cf\u3002\u7531\u4e8ePDMA-r-HPA\u7684\u4fee\u9970\uff0cSPNph1\u7684LCSTs\u662f48\u2103\uff0c\u5728\u6e29\u5ea6\u5347\u9ad8\u7684\u60c5\u51b5\u4e0b\u53ef\u4ee5\u8fdb\u884c\u76f8\u5206\u79bb\u5f62\u6210\u5927\u7684\u7eb3\u7c73\u9897\u7c92\u3002\u56e0\u6b64\uff0cSPNph1\u5177\u6709\u70ed\u54cd\u5e94PA\u7279\u6027\uff0c\u5f53\u6e29\u5ea6\u9ad8\u4e8eLCSTs\u65f6PA\u4fe1\u53f7\u5f3a\u5ea6\u589e\u52a01.6\u500d\u3002\u800c\u6ca1\u6709PDMA-r-HPA\u4fee\u9970\u7684\u5bf9\u7167\u9020\u5f71\u5242\uff08SPNp\uff09\u4e0d\u5177\u6709\u8fd9\u79cd\u6e29\u5ea6\u54cd\u5e94\u6027\u7684PA\u6027\u8d28\u3002\u6b64\u5916\uff0cSPNph1\u7684\u5149\u70ed\u8f6c\u6362\u6548\u7387\u6bd4SPNp\u9ad81.3\u500d\uff0c\u5bfc\u81f4\u5728\u76f8\u540c\u6d53\u5ea6\u4e0bSPNph1\u7684PA\u4fe1\u53f7\u5f3a\u5ea6\u66f4\u9ad8\u3002\u7531\u4e8e\u5176\u8f83\u5c0f\u7684\u5c3a\u5bf8\uff0835 nm\uff09\uff0cSPNph\u901a\u8fc7\u7cfb\u7edf\u6ce8\u5c04\u540e\u80fd\u5f88\u597d\u5730\u805a\u96c6\u5728\u80bf\u7624\u90e8\u5206\u3002\u7531\u4e8eSPNph1\u7684\u70ed\u54cd\u5e94PA\u6027\u8d28\uff0c\u53ef\u4ee5\u901a\u8fc7\u6fc0\u5149\u7167\u5c04\u4ecb\u5bfc\u7684\u5347\u6e29\u6765\u539f\u4f4d\u8fdc\u7a0b\u64cd\u7eb5PA\u4fe1\u53f7\uff0c\u4ece\u800c\u5b9e\u73b0\u80bf\u7624\u90e8\u4f4dSBR\u76841.43\u500d\u589e\u5f3a\u3002\u56e0\u6b64\uff0c\u672c\u7814\u7a76\u4ecb\u7ecd\u4e86\u65b0\u4e00\u4ee3\u5177\u6709\u70ed\u54cd\u5e94\u7279\u6027\u7684\u6709\u673aPA\u9020\u5f71\u5242\uff0c\u53ef\u4ee5\u7528\u4e8e\u80bf\u7624\u90e8\u5206\u5bf9\u6bd4\u589e\u5f3a\u7684\u5149\u58f0\u6210\u50cf\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aThermoresponsive Semiconducting Polymer Nanoparticles for Contrast-Enhanced Photoacoustic Imaging<\/strong>\uff08Adv. Funct. Mater.<\/em>, 2019<\/strong>, DOI:10.1002\/adfm.201903461\uff09<\/p>\n

\u901a\u8baf\u4f5c\u8005\u7b80\u4ecb<\/strong><\/p>\n

\u6d66\u4f83\u88d4\uff0c\u73b0\u4efb\u65b0\u52a0\u5761\u5357\u6d0b\u7406\u5de5\u5927\u5b66\u5316\u5b66\u4e0e\u751f\u7269\u533b\u5b66\u5de5\u7a0b\u5b66\u9662\u526f\u6559\u6388\uff1b2011\u5e74\u4e8e\u65b0\u52a0\u5761\u56fd\u7acb\u5927\u5b66\u83b7\u5f97\u535a\u58eb\u5b66\u4f4d\uff0c\u540c\u5e74\u4f5c\u4e3a\u535a\u58eb\u540e\u52a0\u5165\u65af\u5766\u798f\u5927\u5b66\u4ece\u4e8b\u5206\u5b50\u5f71\u50cf\u5b66\u7814\u7a76\uff0c2015\u5e746\u6708\u4ee5\u526f\u6559\u6388\u53d7\u8058\u4e8e\u5357\u6d0b\u7406\u5de5\u5927\u5b66\u3002<\/strong><\/p>\n

\u8fd1\u5e74\u6765\uff0c\u6d66\u4f83\u88d4\u6559\u6388\u8bfe\u9898\u7ec4\u4e3b\u8981\u63a2\u7d22\u6709\u673a\u6750\u6599\u5728\u751f\u7269\u533b\u5b66\u5149\u5b50\u5b66\u4e2d\u5e94\u7528\u3002\u76ee\u524d\u4e3b\u8981(i)\u9488\u5bf9\u4e34\u5e8a\u9700\u6c42\u5f00\u53d1\u667a\u80fd\u54cd\u5e94\u578b\u6d3b\u4f53\u8367\u5149\u3001\u81ea\u53d1\u5149\u53ca\u5149\u58f0\u6210\u50cf\u5206\u5b50\u63a2\u9488\u7528\u4e8e\u65e9\u671f\u75be\u75c5\u8bca\u65ad;(ii) \u9488\u5bf9\u57fa\u7840\u751f\u7269\u533b\u5b66\u5f00\u53d1\u57fa\u4e8e\u534a\u5bfc\u4f53\u805a\u5408\u7269(SPN\uff1asemiconducting polymer nanoparticles)\u7684\u7eb3\u7c73\u5149\u5b50\u8f6c\u6362\u5668\u7528\u4e8e\u5728\u5206\u5b50\u5c42\u9762\u8c03\u63a7\u5e76\u4e86\u89e3\u751f\u7269\u8fc7\u7a0b\uff1b(iii)\u7814\u7a76\u6709\u673a\u5149\u5b66\u6750\u6599\u5728\u80bf\u7624\u6cbb\u7597\u4e2d\u7684\u5e94\u7528\u3002\u76ee\u524d\uff0c\u8be5\u8bfe\u9898\u7ec4\u5df2\u5728\u764c\u75c7\u8bca\u7597\u3001\u76ae\u80a4\u75c5\u68c0\u6d4b\u4e0e\u836f\u7269\u6bd2\u6027\u7b5b\u9009\u4e2d\u53d6\u5f97\u521d\u6b65\u8fdb\u5c55\u3002\u4f8b\u5982\uff0c\u57282017\u5e74\u8be5\u8bfe\u9898\u7ec4\u9996\u6b21\u5f00\u521b\u4e86\u57fa\u4e8e\u53ef\u964d\u89e3\u6709\u673a\u9ad8\u5206\u5b50\u7eb3\u7c73\u9897\u7c92\u7684\u5206\u5b50\u4f59\u8f89\u6210\u50cf(MAI: molecular afterglow imaging)\uff0c\u5e76\u63a2\u7d22\u4e86\u5176\u5728\u75be\u75c5\u7684\u65e9\u671f\u8bca\u65ad\u548c\u6cbb\u7597\u65b9\u9762\u7684\u6f5c\u5728\u5e94\u7528\u3002\u8be5\u7814\u7a76\u6210\u679c\u53d1\u8868\u4e8e\u56fd\u9645\u9876\u7ea7\u671f\u520aNature Biotechnology\u3002\u57282019\u5e74\u8be5\u8bfe\u9898\u7ec4\u8bbe\u8ba1\u4e86\u4e00\u79cd\u5177\u6709\u9ad8\u6548\u7684\u80be\u6e05\u9664\u6548\u7387\u7684\u5206\u5b50\u80be\u810f\u63a2\u9488(MRPs: molecular renal probes)\u7528\u4e8e\u5bf9\u836f\u7269\u6027\u6025\u6027\u80be\u635f\u4f24(AKI: acute kidney injury)\u7684\u4f53\u5185\u5149\u5b66\u6210\u50cf\u3002\u8be5\u63a2\u9488\u7684\u8fd1\u7ea2\u5916\u8367\u5149\u6216\u8005\u5316\u5b66\u53d1\u5149\u4fe1\u53f7\u53ef\u4ee5\u88abAKI\u7684\u524d\u671f\u751f\u7269\u6807\u8bb0\u7269\u7279\u5f02\u6027\u5730\u6fc0\u6d3b\uff0c\u4f7f\u5f97\u8be5\u63a2\u9488\u53ef\u4ee5\u5bf9\u5b9e\u9a8c\u5c0f\u9f20\u80be\u810f\u5185\u591a\u4e2a\u5206\u5b50\u4e8b\u4ef6\u8fdb\u884c\u7eb5\u5411\u6210\u50cf\u3002\u8be5\u7814\u7a76\u6210\u679c\u53d1\u8868\u4e8e\u56fd\u9645\u9876\u7ea7\u671f\u520aNature Materials\u3002\u53e6\u5916\uff0c\u91c7\u7528\u8fd1\u7ea2\u5916\u8367\u5149\u548c\u5149\u58f0\u7b49\u6210\u50cf\u6280\u672f\uff0c\u8be5\u7ec4\u5b9e\u73b0\u4e86\u76ae\u80a4\u75c5\u3001\u809d\u635f\u4f24\u4ee5\u53ca\u80bf\u7624\u7b49\u75be\u75c5\u53d1\u5c55\u8fc7\u7a0b\u4e2d\u76f8\u5173\u751f\u7269\u6807\u8bb0\u7269\u7684\u6d3b\u4f53\u68c0\u6d4b\uff0c\u4e3a\u75be\u75c5\u7684\u65e9\u671f\u8bca\u65ad\u63d0\u4f9b\u4e86\u6709\u7528\u4fe1\u606f\u3002\u8be5\u56e2\u961f\u7814\u7a76\u65b9\u5411\u4e5f\u6d89\u53ca\u667a\u80fd\u54cd\u5e94\u578b\u7eb3\u7c73\u533b\u836f\uff0c\u5149\u70ed\u8c03\u63a7\u79bb\u5b50\u901a\u9053\u3001\u57fa\u56e0\u8868\u8fbe\u548c\u86cb\u767d\u6d3b\u6027\u7b49\u76f8\u5173\u7814\u7a76\u3002\u81ea2015\u5e746\u6708\u6210\u7acb\u81f3\u4eca\uff0c\u8be5\u56e2\u961f\u5df2\u5728\u56fd\u9645\u4e3b\u6d41\u671f\u520a\u4e0a\u53d1\u8868\u9ad8\u6c34\u5e73\u6587\u7ae080\u591a\u7bc7\uff08\u5305\u62ecNature Materials, Nature Biotechnology, Nature Communications, Chemical Society Reviews, Accounts of Chemical Research, Journal of the American Chemical Society, Angewandte Chemie International Edition, Advanced Materials, Nano Letters, ACS Nano\u7b49\uff09\u3002\u81f3\u4eca\uff0c\u6d66\u4f83\u88d4\u6559\u6388\u7d2f\u8ba1\u53d1\u8868\u9ad8\u6863\u6b21\u6587\u7ae0140\u591a\u7bc7\uff0cSCI H-index = 60\u3002\u76ee\u524d\uff0c\u6d66\u4f83\u88d4\u535a\u58eb\u62c5\u4efbACS Applied Polymer Materials \u548cBiomaterials Research\u526f\u4e3b\u7f16\uff0cNano Research\u671f\u520aYoung Star\u4e3b\u7f16\uff0cAdvanced Functional Materials, Bioconjugate Chemistry, ACS Applied Bio Materials, Advanced Biosystems\u548cChemNanoMat\u7b49\u671f\u520a\u7f16\u59d4\u3002<\/p>\n

\u8bfe\u9898\u7ec4\u4e3b\u9875\uff1ahttp:\/\/www.ntu.edu.sg\/home\/kypu\/index.html<\/strong><\/p>\n

\u8fd1\u671f\u4ee3\u8868\u6027\u5de5\u4f5c\uff1a<\/strong><\/p>\n

1. J. Huang, J. Li, Y. Lyu, Q. Miao, K. Pu*. Molecular optical imaging probes for early diagnosis of drug-induced acute kidney injury. Nat. Mater.<\/em>, 2019<\/strong>, DOI: 10.1038\/s41563-019-0378-4.<\/p>\n

2. Q. Miao, C. Xie, X. Zhen, Y. Lyu, H. Duan, X. Liu, J. Jokerst, K Pu*. Molecular afterglow imaging with bright, biodegradable polymer nanoparticles. Nat. Biotechnol.<\/em>, 2017<\/strong>, 35, 1102-1110.<\/p>\n

3. Y. Jiang, J. Huang, X. Zhen, Z. Zeng, J. Li, C. Xie, Q. Miao, J. Chen, P. Chen, K. Pu*. A generic approach towards afterglow luminescent nanoparticles for ultrasensitive in vivo imaging. Nat. Commun.<\/em>, 2019<\/strong>, 10, 2064.<\/p>\n

4. P. Cheng, Q. Miao, J. Li, J. Huang, C. Xie, K. Pu*. J. Am. Chem. Soc.<\/em>, 2019<\/strong>, 141, 27, 10581-10584.<\/p>\n

5. J. Li, J. Huang, Y. Lyu, J. Huang, Y. Jiang, C. Xie, K. Pu*. Photoactivatable organic semiconducting pro-nanoenzymes. J. Am. Chem. Soc.<\/em>, 2019<\/strong>, 141, 4073-4079.<\/p>\n

6. S. He, C. Xie, Y. Jiang, K. Pu*. An organic afterglow protheranostic nanoassembly. Adv. Mater.<\/em>, 2019<\/strong>, 31, 1902672.<\/p>\n

7. Y. Jiang, J. Li, Z. Zeng, C. Xie, Y. Lyu, K. Pu*. Organic photodynamic nanoinhibitor for synergistic cancer therapy. Angew. Chem., Int. Ed.<\/em>, 2019<\/strong>, 58, 8161-8165.<\/p>\n

8. D. Cui, J. Huang, X. Zhen, J. Li, Y. Jiang, K. Pu*. Semiconducting polymer nano-prodrug for hypoxia-activated synergetic photodynamic cancer therapy. Angew. Chem., Int. Ed.<\/em>, 2019<\/strong>, 58, 5920-5924.<\/p>\n

9. Y. Lyu, D. Cui, J. Huang, W. Fan, Y. Miao, K. Pu*. Near-infrared afterglow semiconducting nano-polycomplexes for multiplex differentiation of cancer exosomes. Angew. Chem., Int. Ed.<\/em>, 2019<\/strong>, 58, 4983-4987.<\/p>\n

10. Y. Jiang, P. Upputuri, C. Xie, Z. Zeng, A. Sharma, X. Zhen, J. Li, J. Huang, M. Pramanik, K. Pu*. Metabolizable semiconducting polymer nanoparticles for second near-infrared photoacoustic imaging. Adv. Mater.<\/em>, 2019<\/strong>, 31, 1808166.<\/p>\n

11. J. Li, K. Pu*. Development of organic semiconducting materials for deep-tissue optical imaging, phototherapy and photoactivation. Chem. Soc. Rev.<\/em>, 2019<\/strong>, 48, 38-71.<\/p>\n

\u672c\u6587\u7531CQR\u7f16\u8bd1\u3002<\/p>\n

\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1tougao@cailiaoren.com.<\/p>\n

\u6295\u7a3f\u4ee5\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1acailiaokefu.<\/p>\n","protected":false},"excerpt":{"rendered":"

\u3010\u80cc\u666f\u4ecb\u7ecd\u3011 \u5149\u58f0\uff08photoacoustic, PA\uff09\u6210\u50cf\u662f\u4e00\u79cd\u68c0\u6d4b\u5149\u80fd\u8f6c\u6362\u4e3a\u8d85\u58f0\u6ce2\u7684\u6df7\u5408\u578b\u975e\u7535\u79bb\u6210\u50cf\u6280\u672f\u3002\u8d85\u58f0\u6ce2\u5728\u7a7f\u8fc7\u7ec4\u7ec7\u65f6\u6563\u5c04\u6bd4\u5149\u66f4\u5c11\uff0c\u6240\u4ee5PA\u6210\u50cf\u5177\u6709\u66f4…<\/p>\n","protected":false},"author":7770,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215,2],"tags":[4124],"class_list":["post-181754","post","type-post","status-publish","format-standard","hentry","category-jiedu","category-keji","tag-pdma-r-hpaspnph1"],"_links":{"self":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/181754"}],"collection":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/users\/7770"}],"replies":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=181754"}],"version-history":[{"count":3,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/181754\/revisions"}],"predecessor-version":[{"id":181967,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/181754\/revisions\/181967"}],"wp:attachment":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=181754"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=181754"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=181754"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}