{"id":182693,"date":"2019-08-12T06:30:11","date_gmt":"2019-08-11T22:30:11","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=182693"},"modified":"2019-10-18T18:31:06","modified_gmt":"2019-10-18T10:31:06","slug":"%e3%80%90%e5%ae%a1%e7%a8%bf%e5%b7%b2%e5%9b%9e%e5%a4%8d%e3%80%91%e5%8d%97%e6%b4%8b%e7%90%86%e5%b7%a5yong-ken-tye%ef%bc%8c%e6%b7%b1%e5%9c%b3%e5%a4%a7%e5%ad%a6%e5%be%90%e6%94%b9%e9%9c%9e%e5%92%8cnih","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=182693","title":{"rendered":"\u5357\u6d0b\u7406\u5de5Yong Ken-Tye\uff0c\u6df1\u5733\u5927\u5b66\u8bb8\u6539\u971e\u548cNIH\u9648\u5c0f\u5143Chem. Rev.:\u7528\u4e8e\u751f\u7269\u5b66\u548c\u533b\u5b66\u7684\u7eb3\u7c73\u78b3\uff1a\u4f20\u611f\uff0c\u6210\u50cf\u548c\u836f\u7269\u4f20\u9012"},"content":{"rendered":"

\u3010\u5f15\u8a00<\/strong>\u3011<\/p>\n

\u7eb3\u7c73\u6280\u672f\u5728\u751f\u7269\u533b\u5b66\u7814\u7a76\u4e2d\u53d1\u6325\u7740\u5173\u952e\u4f5c\u7528\u3002\u7eb3\u7c73\u6750\u6599\u7684\u7269\u7406\u548c\u5316\u5b66\u6027\u8d28\u662f\u72ec\u7279\u7684\uff0c\u5e76\u4e14\u7531\u4e8e\u5176\u8d85\u5c0f\u5c3a\u5bf8\u7684\u8303\u56f4\uff081\u81f3100nm\uff09\u800c\u4e0e\u5b83\u4eec\u7684\u5927\u5757\u5bf9\u5e94\u7269\u5177\u6709\u4e0d\u540c\u7684\u6027\u8d28\u3002\u534a\u5bfc\u4f53\u91cf\u5b50\u70b9\uff08QD\uff09\u7684\u53d1\u5149\u7279\u6027\u5df2\u7ecf\u5e7f\u6cdb\u7528\u4e8e\u4f53\u5916\u548c\u4f53\u5185\u6210\u50cf\uff0c\u800c\u91d1\u5c5e\u7eb3\u7c73\u9897\u7c92\u7684\u5f3a\u5149\u5b66\u5438\u6536\u5cf0\u5bf9\u5468\u56f4\u4ecb\u8d28\u975e\u5e38\u654f\u611f\uff0c\u56e0\u6b64\u80fd\u591f\u8fdb\u884c\u6bd4\u8272\u68c0\u6d4b\u3002\u5728\u8fc7\u53bb\u7684\u51e0\u5e74\u4e2d\uff0c\u7531\u4e8e\u7eb3\u7c73\u78b3\u6750\u6599\u7684\u4f4e\u6bd2\u6027\uff0c\u5927\u89c4\u6a21\u751f\u4ea7\u7684\u4f4e\u6210\u672c\u4ee5\u53ca\u591a\u529f\u80fd\u7684\u8868\u9762\u529f\u80fd\u5316\uff0c\u7eb3\u7c73\u78b3\u6750\u6599\u5df2\u6210\u4e3a\u5404\u79cd\u751f\u7269\u5b66\u5e94\u7528\uff08\u5982\u4f20\u611f\uff0c\u6210\u50cf\u548c\u836f\u7269\u8f93\u9001\uff09\u7684\u5176\u4ed6\u7eb3\u7c73\u6750\u6599\u7684\u66ff\u4ee3\u54c1\u3002\u6b64\u5916\uff0c\u78b3\u662f\u5730\u7403\u4e0a\u6700\u4e30\u5bcc\u7684\u5143\u7d20\u4e4b\u4e00\u3002\u7eb3\u7c73\u7ea7\u78b3\u7684\u540c\u7d20\u5f02\u5f62\u4f53\u5305\u62ec0D\u5bcc\u52d2\u70ef\u548c\u78b3\u7eb3\u7c73\u70b9\uff0c1D\u78b3\u7eb3\u7c73\u7ba1\/\u7eb3\u7c73\u89d2\u548c\u77f3\u58a8\u70ef\u7eb3\u7c73\u5e26\uff0c2D\u77f3\u58a8\u70ef\u548c\u6c27\u5316\u77f3\u58a8\u70ef\uff0c\u4ee5\u53ca3D\u7eb3\u7c73\u91d1\u521a\u77f3\u3002\u5728\u6240\u6709\u8fd9\u4e9b\u540c\u7d20\u5f02\u5f62\u4f53\u4e2d\uff0c\u77f3\u58a8\u70ef\u662f\u57282004\u5e74\u7531Andre Geim\u548cKostya Novoselov\u53d1\u73b0\u7684\u3002<\/p>\n

\u8bb8\u591a\u7eb3\u7c73\u78b3\u6750\u6599\u7684\u4e00\u4e2a\u6301\u4e45\u6311\u6218\u662f\u5b83\u4eec\u7684\u7269\u7406\u548c\u5316\u5b66\u6027\u8d28\u4e0d\u5982\u7ade\u4e89\u6750\u6599\u90a3\u4e48\u7cbe\u786e\u3002\u5b83\u4eec\u4e0d\u4ec5\u6bd4\u6709\u673a\u67d3\u6599\u7b49\u5206\u5b50\u79cd\u7c7b\u66f4\u4e0d\u786e\u5b9a\uff0c\u800c\u4e14\u4e0eQD\uff0c\u8d35\u91d1\u5c5e\u7eb3\u7c73\u9897\u7c92\u4ee5\u53ca\u5728\u751f\u7269\u533b\u5b66\u5e94\u7528\u4e2d\u5177\u6709\u6f5c\u529b\u7684\u7c7b\u4f3c\u7eb3\u7c73\u7ed3\u6784\u76f8\u6bd4\u4e5f\u4e0d\u592a\u7cbe\u786e\u3002\u8fd9\u4f7f\u5f97\u5bf9\u4ed6\u4eec\u7684\u7406\u89e3\u4ea7\u751f\u4e86\u4e0d\u786e\u5b9a\u6027\uff0c\u8fd9\u4e9b\u7269\u7406\u548c\u5316\u5b66\u73b0\u8c61\u5b9a\u4e49\u4e86\u5b83\u4eec\u7684\u8868\u9762\u72b6\u6001\uff0c\u5b83\u4eec\u7684\u8868\u9762\u53ef\u4ee5\u88ab\u529f\u80fd\u5316\u7684\u65b9\u5f0f\uff0c\u4ee5\u53ca\u5b83\u4eec\u7684\u5149\u81f4\u53d1\u5149\u548c\u5176\u4ed6\u6027\u8d28\u7684\u673a\u5236\u3002\u56e0\u6b64\uff0c\u91cd\u8981\u7684\u662f\u63cf\u8ff0\u8868\u5f81\u65b9\u6cd5\u5e76\u7406\u89e3\u7eb3\u7c73\u78b3\u6750\u6599\u7684\u7269\u7406\u6027\u8d28\u548c\u8868\u9762\u5316\u5b66\uff0c\u4ee5\u5bfb\u6c42\u76d1\u7ba1\u90e8\u95e8\u6279\u51c6\u5176\u5728\u5404\u79cd\u5e94\u7528\u4e2d\u7684\u4f7f\u7528\u3002<\/p>\n

\u6b64\u5916\uff0c\u7eb3\u7c73\u78b3\u6750\u6599\u7684\u53ef\u8c03\u5149\u5b66\u548c\u7535\u5b50\u7279\u6027\uff0c\u5b83\u4eec\u7b80\u5355\u7684\u5408\u6210\u6280\u672f\uff0c\u4ee5\u53ca\u5b83\u4eec\u4e0e\u5404\u79cd\u914d\u4f53\u548c\u751f\u7269\u5206\u5b50\u7684\u901a\u7528\u529f\u80fd\u5316\u76f8\u5bb9\u6027\uff0c\u4f7f\u5f97\u5b83\u4eec\u5728\u4f53\u5916\u548c\u4f53\u5185\u7684\u751f\u7269\u4f20\u611f\uff0c\u751f\u7269\u6210\u50cf\u548c\u836f\u7269\u9012\u9001\u4e2d\u7684\u5e94\u7528\u90fd\u975e\u5e38\u6709\u7528\u3002\u867d\u7136\u8fd9\u4e9b\u6027\u8d28\u4f7f\u5b83\u4eec\u5728\u7eb3\u7c73\u533b\u5b66\u9886\u57df\u5907\u53d7\u5173\u6ce8\uff0c\u4f46\u662f\u5728\u6211\u4eec\u9884\u6d4b\u5b83\u4eec\u5728\u4e34\u5e8a\u6cbb\u7597\u4e2d\u7684\u6210\u529f\u4e4b\u524d\uff0c\u5fc5\u987b\u4ed4\u7ec6\u7814\u7a76\u548c\u5206\u6790\u4e0d\u540c\u7eb3\u7c73\u78b3\u6750\u6599\u7684\u6bd2\u6027\u6548\u5e94\uff0c\u4ee5\u53ca\u5b83\u4eec\u5728\u5404\u79cd\u7ec4\u7ec7\u548c\u5668\u5b98\u4e2d\u7684\u751f\u7269\u5206\u5e03\u3002\u4e3a\u6b64\uff0c\u9700\u8981\u4ed4\u7ec6\u548c\u8be6\u7ec6\u5730\u53cd\u601d\u5f71\u54cd\u5185\u5728\u6bd2\u6027\u673a\u5236\u7684\u56e0\u7d20\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb<\/strong>\u3011<\/p>\n

\u8fd1\u65e5\uff0c\u5357\u6d0b\u7406\u5de5\u5927\u5b66Yong Ken-Tye\uff0c\u6df1\u5733\u5927\u5b66\u8bb8\u6539\u971e\u548cNIH\u9648\u5c0f\u5143<\/strong>\u5728\u8fd9\u7bc7\u7efc\u8ff0\u7cfb\u7edf\u5730\u6982\u8ff0\u4e86\u7eb3\u7c73\u78b3\u6750\u6599\u7684\u6700\u65b0\u6cbb\u7597\u5e94\u7528\uff0c\u7efc\u5408\u6bd4\u8f83\u4e86\u4e0d\u540c\u78b3\u7eb3\u7c73\u6750\u6599\u7684\u7279\u6027\uff0c\u4ee5\u53ca\u8fd9\u4e9b\u7279\u6027\u4ee5\u53ca\u836f\u4ee3\u52a8\u529b\u5b66\u548c\u6bd2\u7406\u5b66\u6548\u5e94\u5982\u4f55\u5f71\u54cd\u5b83\u4eec\u7684\u6cbb\u7597\u5e94\u7528\u3002\u8be5\u7efc\u8ff0\u6db5\u76d6\u4e86\u57fa\u4e8e\u5404\u79cd\u7eb3\u7c73\u78b3\u6750\u6599\u7684\u4f53\u5916\u548c\u4f53\u5185\u4f20\u611f\uff0c\u6210\u50cf\u548c\u836f\u7269\u4f20\u9012\u7cfb\u7edf\u7684\u7814\u7a76\u4eae\u70b9\uff0c\u65e8\u5728\u4e3a\u7814\u7a76\u4eba\u5458\u9009\u62e9\u548c\u8bbe\u8ba1\u7528\u4e8e\u764c\u75c7\u6cbb\u7597\u5e94\u7528\u7684\u5de5\u5177\u3002\u8be5\u6210\u679c\u4ee5\u9898\u4e3a\u201cNanocarbons for Biology and Medicine: Sensing, Imaging, and Drug Delivery\u201d\u53d1\u8868\u5728Chem. Rev.\u4e0a\u3002<\/strong><\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

Figure 1.<\/strong>\u7efc\u8ff0\u7684\u6982\u62ec<\/strong><\/p>\n

\"\"<\/p>\n

Figure 2.<\/strong>\u7528\u4e8e\u4f53\u5916\u4f20\u611f\u7684\u57fa\u4e8e\u78b3\u7eb3\u7c73\u6750\u6599\u7684\u4f20\u611f\u5668\u7684\u4ee3\u8868\u6027\u56fe\u50cf<\/strong><\/p>\n

\"\"<\/p>\n

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\uff08C\uff09\u57fa\u4e8eFRET\u7684\u6bd4\u7387\u5f0f\u78b3\u70b9\u4f20\u611f\u5668\uff0c\u7528\u4e8e\u91cf\u5316\u6c34\u4ecb\u8d28\uff0c\u8840\u6e05\u548c\u6d3b\u7ec6\u80de\u4e2d\u7684\u6c22\u786b\u5316\u7269\uff08H2<\/sub>S\uff09\uff0c\u68c0\u6d4b\u9650\u4e3a10 nM\u3002<\/p>\n

Figure 3.<\/strong>\u7528\u4e8e\u68c0\u6d4b<\/strong>CRP<\/strong>\u7684\u57fa\u4e8e\u77f3\u58a8\u70ef\u7684<\/strong>CRET<\/strong>\u5e73\u53f0\u7684\u793a\u610f\u56fe<\/strong><\/p>\n

\"\"<\/p>\n

Figure 4.rGO-BiVO4<\/sub><\/strong>\u7eb3\u7c73\u590d\u5408\u6750\u6599\u4e0e\u8fc7\u6c27\u8349\u9178\u76d0\u5316\u5b66\u53d1\u5149\u81ea\u53d1\u5149\u7535\u6c60\u548c\u6570\u5b57\u4e07\u7528\u8868\u7535\u8def\u76f8\u7ed3\u5408<\/strong><\/p>\n

\"\"<\/p>\n

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\uff08B-a\uff09GOx\u50ac\u5316\u6eb6\u6db2\u7684pH\uff0c\u548c\uff08B-b\uff09PEC\u68c0\u6d4b\u6c60\u4e2dPBS\u7684pH\u503c\u5bf9\u81ea\u53d1\u5149\u7684\u5149\u7535\u6d41\u7684\u5f71\u54cd PEC\u514d\u75ab\u6d4b\u5b9a\uff08\u5728\u8be5\u60c5\u51b5\u4e0b\u4f7f\u75280.5 ng \/ mL PSA\uff09<\/p>\n

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Figure 5.<\/strong>\u53ef\u8c03\u8c10\u77f3\u58a8\u70ef\u4e2d\u7ea2\u5916\u751f\u7269\u4f20\u611f\u5668<\/strong><\/p>\n

\"\"<\/p>\n

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\uff08B\uff09\u77f3\u58a8\u70ef\u7eb3\u7c73\u5e26\u9635\u5217\u7684SEM\u56fe\u50cf<\/p>\n

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Figure 6.<\/strong>\u57fa\u4e8e<\/strong>SWCNHs<\/strong>\u7684\u8367\u5149\u9002\u4f53\u4f20\u611f\u5668\uff0c\u7528\u4e8e\u9776\u5411\u68c0\u6d4b\u51dd\u8840\u9176\u5206\u5b50<\/strong><\/p>\n

\"\"<\/p>\n

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\uff08C\uff09\u5728\u7a7a\u767d\u7f13\u51b2\u6db2\u4e2d\u6dfb\u52a0\u7684\u9002\u4f53\u4f20\u611f\u5668\u7684\u8367\u5149\u54cd\u5e94\uff0c\u7f13\u51b2\u6db2\u4e2d\u7684100nM BSA\uff0c\u7f13\u51b2\u6db2\u4e2d\u7684100nM IgG\u548c\u7f13\u51b2\u6db2\u4e2d\u7684100nM\u51dd\u8840\u9176\u3002<\/p>\n

\uff08D\uff09\u67e0\u6aac\u9178\u76d0\u5b98\u80fd\u5316\u7684\u4e0a\u8f6c\u6362\u7eb3\u7c73\u9897\u7c92-ssDNA\u7684\u5236\u5907\u7684\u793a\u610f\u56fe\u3002<\/p>\n

\uff08E\uff09\u4f7f\u7528\u57fa\u4e8eLRET\u7684\u68c0\u6d4b\u4f7f\u7528\u67e0\u6aac\u9178\u76d0\u5b98\u80fd\u5316\u7684\u4e0a\u8f6c\u6362\u7eb3\u7c73\u9897\u7c92-ssDNA\u548cSWCNH\u7528\u4e8e\u68c0\u6d4b\u6025\u6027\u65e9\u5e7c\u7c92\u7ec6\u80de\u767d\u8840\u75c5\u7684\u793a\u610f\u56fe\u3002<\/p>\n

\uff08F\uff09\u591a\u91cd\u67e0\u6aac\u9178\u76d0\u5b98\u80fd\u5316\u7684\u4e0a\u8f6c\u6362\u7eb3\u7c73\u9897\u7c92-ssDNA-SWCNHs\u7eb3\u7c73\u5e73\u677f\u4e0e\u4e0d\u540c\u6d53\u5ea6\u7684\u9776DNA\u7684\u53d1\u5149\u54cd\u5e94\u3002<\/p>\n

\uff08G\uff09\u5728545nm\u5904\u89c2\u5bdf\u5230\u7684\u4e0a\u8f6c\u6362\u53d1\u5149\u5f3a\u5ea6\u4e0e\u9776DNA\u6d53\u5ea6\u4e4b\u95f4\u7684\u7ebf\u6027\u5173\u7cfb\u3002<\/p>\n

Figure 7.CNHs<\/strong>\u4e0e\u949b\u5408\u91d1\u95f4\u63a5\u7ba1\u7ed3\u5408\uff0c\u7528\u4e8e\u589e\u5f3a\u53f6\u9178\u7684<\/strong>PEC<\/strong>\u4f20\u611f<\/strong><\/p>\n

\"\"<\/p>\n

\uff08A\uff09\u5728\u5149\u7167\u5c04\u4e0b\u949b\u9178\u76d0\u7eb3\u7c73\u7ba1\/CNHs\/GCE\u7ed3\u6784\u4e0a\u7684\u7535\u8377\u8f6c\u79fb\u7684\u793a\u610f\u56fe\u3002<\/p>\n

\uff08B\uff09\u7535\u6d41\u5bc6\u5ea6\u548cFA\u6d53\u5ea6\u7684\u7ebf\u6027\u6821\u51c6\u66f2\u7ebf\u3002\u63d2\u56fe\u56fe\u50cf\u662f\u57fa\u4e8e\u65f6\u95f4\u7684\u5149\u7535\u6d41\u54cd\u5e94\u7684\u7535\u6d41I-t\u66f2\u7ebf\u3002<\/p>\n

\uff08C\uff09\u9009\u62e9\u6027\u5b9e\u9a8c<\/p>\n

Figure 8.<\/strong>\u57fa\u4e8e\u78b3\u91cf\u5b50\u70b9\uff08<\/strong>CQD<\/strong>\uff09\u7684\u53cc\u6a21\u4f20\u611f\u5668\uff0c\u7528\u4e8e<\/strong>GSH<\/strong>\u7684\u8367\u5149\u548c\u6bd4\u8272\u4f20\u611f<\/strong><\/p>\n

\"\"<\/p>\n

\uff08A\uff09\u4f7f\u7528\u53cc\u6a21\u5f0f\u6bd4\u8272\u548c\u8367\u5149\u7eb3\u7c73\u4f20\u611f\u5668\u7684GSH\u68c0\u6d4b\u7684\u793a\u610f\u56fe\u3002<\/p>\n

\uff08B\uff09\u7531CQD\u8bf1\u5bfc\u7684\u805a\u96c6\u7684AuNP\u7684TEM\u56fe\u50cf\uff0c\u4e0d\u6dfb\u52a0GSH;<\/p>\n

\uff08C\uff09\u901a\u8fc7\u6dfb\u52a0CQD\u548cGSH\u5206\u6563AuNP\u3002<\/p>\n

\uff08D\uff09CQD\u548cAuNP\u7684\u56fe\u50cf\u4e0e\u4ece\u5de6\u5230\u53f3\u7684GSH\u6d53\u5ea6\u589e\u52a0\u6df7\u5408\u3002<\/p>\n

\uff08E\uff09\u4ece\u5de6\u5230\u53f3\uff0c\u6ca1\u6709\u548c\u6dfb\u52a0GSH\u7684CQD\u6eb6\u6db2\u548cCQD\u548cAuNP\u7684\u6df7\u5408\u7269\u7684\u56fe\u50cf\u3002<\/p>\n

Figure 9.<\/strong>\u7528\u4e8e\u591a\u91cd\u76ee\u6807\u68c0\u6d4b\u7684<\/strong>ssDNA-GO<\/strong>\u67b6\u6784\u5e73\u53f0\u7684\u793a\u610f\u56fe<\/strong><\/p>\n

\"\"<\/p>\n

\uff08A\uff09\u5728\u5b58\u5728\u4e92\u8865\u9776T3\u7684\u60c5\u51b5\u4e0b\uff0cP3\u4e0eT3\u53cd\u5e94\u5f62\u6210P3-T3\u590d\u5408\u7269\uff0c\u5176\u4e0eGO\u8868\u9762\u5206\u79bb\uff0c\u5bfc\u81f4\u8367\u5149\u201c\u5f00\u201d\u72b6\u6001\u3002<\/p>\n

\uff08B\uff09P1\u901a\u8fc7\u63a2\u9488-GO\u7ed3\u6784\u7684\u5f62\u6210\u5448\u73b0\u8367\u5149\u201coff\u201d\u72b6\u6001\uff0c\u4f46\u901a\u8fc7\u4e0e\u51dd\u8840\u9176\u7684\u76f8\u4e92\u4f5c\u7528\u5207\u6362\u5230\u201c\u5f00\u542f\u201d\u72b6\u6001\u3002<\/p>\n

\uff08C\uff09\u5728Ag+<\/sup>\u6216Hg2+<\/sup>\u5b58\u5728\u4e0b\uff0cP4\u6216P5\u81ea\u6298\u53e0\u5f62\u6210\u7a33\u5b9a\u7684C-Ag+<\/sup>-C\u6216T-Hg2+<\/sup>-T\u7ed3\u6784\uff0c\u5bfc\u81f4\u8367\u5149\u201c\u5f00\u201d\u72b6\u6001\u3002\u7136\u800c\uff0c\u901a\u8fc7\u7ee7\u7eed\u5411\u4e0a\u8ff0\u6eb6\u6db2\u4e2d\u52a0\u5165\u534a\u80f1\u6c28\u9178\uff0cC-Ag+<\/sup>-C\u6216T-Hg2+<\/sup>-T\u7ed3\u6784\u88ab\u534a\u80f1\u6c28\u9178\u548cAg+<\/sup>\u6216Hg2+<\/sup>\u4e4b\u95f4\u7684Ag-S\u6216Hg-S\u952e\u7834\u574f\uff0c\u8f6c\u6362\u4e3a\u8367\u5149\u201coff\u201d\u518d\u6b21\u58f0\u660e\u3002<\/p>\n

Figure 10.<\/strong>\u94f6\u7eb3\u7c73\u7c07\u7528\u4e8e\u4f20\u611f<\/strong><\/p>\n

\"\"<\/p>\n

\uff08A\uff09\u5728\u6c34\u6eb6\u6db2\u4e2dDNA\u652f\u67b6\u4e0a\u5236\u5907\u94f6\u7eb3\u7c73\u56e2\u7c07\u7684\u793a\u610f\u56fe\u3002<\/p>\n

\uff08B\uff09\u4f7f\u7528AgNCs-GO\u7eb3\u7c73\u6742\u5316\u6750\u6599\u8fdb\u884c\u65e0\u6807\u8bb0DNA\u68c0\u6d4b\u7684\u6d4b\u5b9a\u7684\u793a\u610f\u56fe\u3002<\/p>\n

Figure 11.<\/strong>\u8fd8\u539f\u6c27\u5316\u77f3\u58a8\u70ef\u751f\u7269\u4f20\u611f\u5e73\u53f0<\/strong><\/p>\n

\"\"<\/p>\n

\uff08A\uff09\u8fd8\u539f\u6c27\u5316\u77f3\u58a8\u70ef\u751f\u7269\u4f20\u611f\u5e73\u53f0\u7684\u793a\u610f\u56fe\u3002<\/p>\n

\uff08B\uff09\u901a\u8fc70.6\uff05\u743c\u8102\u7cd6\u51dd\u80f6\u7535\u6cf3\u5206\u6790\u6eda\u73af\u6269\u589e\u4ea7\u7269\u3002 \u6bcf\u4e2a\u53cd\u5e94\u572830\u2103\u4e0b\u572860\u03bcL\u9776\u7ed3\u5408\u7f13\u51b2\u6db2\uff08TBB\uff1a20mM PBS\uff0c150mM NaCl\uff0c20mM KCl\uff0c5mM MgCl2<\/sub>\uff0cpH 7.5\uff09\u4e2d\u8fdb\u884c1\u5c0f\u65f6\uff0c\u6240\u8ff0\u9776\u7ed3\u5408\u7f13\u51b2\u6db2\u542b\u6709\u6307\u793a\u7684rGO\u5438\u9644\u7684TP1\u7ec4\u5206\uff08250\uff09\u3002 nM\uff09\uff0c\u73af\u72b6DNA\u6a21\u677f1\uff088nM\uff09\u548c\u51dd\u8840\u9176\uff08Thr; 200nM\uff09\u3002<\/p>\n

\uff08C\uff09\u5728Thr\uff08200nM\uff09\uff0c\u73af\u72b6DNA\u6a21\u677f1\uff088nM\uff09\u6216\u4e24\u8005\u5b58\u5728\u4e0b\uff0c\u8fd8\u539f\u7684GO-\u5438\u9644\u7684FAM\u6807\u8bb0\u7684TP1\uff08250nM\uff09\u7684\u65f6\u95f4\u4f9d\u8d56\u6027\u8367\u5149\u54cd\u5e94\u3002\u03bbex<\/sub>\/\u03bbem<\/sub>= 494\/518nm\u3002<\/p>\n

Figure 12.DNA<\/strong>\u7684\u68c0\u6d4b<\/strong><\/p>\n

\"\"<\/p>\n

\uff08A\uff09DNA\u68c0\u6d4b\u7a0b\u5e8f\u7684\u793a\u610f\u56fe\u3002<\/p>\n

\uff08B\uff09\u5728\u5b58\u5728\u4e0d\u540c\u91cf\u7684DNA\u65f6\uff0c\u5728652nm\u5904\u7684\u65f6\u95f4\u4f9d\u8d56\u6027\u5438\u5149\u5ea6\u53d8\u5316\u8303\u56f4\u4e3a0\u81f3200nM\uff080,0.5,1,2,5,8,10,20,50,80,100,200nM\uff09\uff09\u3002<\/p>\n

\uff08C\uff09\u5bf9\u5e94\u4e8e10\u5206\u949f\u95f4\u9694\u540e\u5404\u79cd\u6d53\u5ea6\u7684DNA\u7684\u5438\u5149\u5ea6\u7684\u6821\u51c6\u66f2\u7ebf\u3002\u63d2\u56fe\uff1a\u7ebf\u6027\u56fe\u3002<\/p>\n

\uff08D\uff09\u5728652nm\u5904\u7684\u65f6\u95f4\u4f9d\u8d56\u6027\u5438\u5149\u5ea6\uff0c\u5176\u4e2dDNA-GH\u6742\u4ea4\u4f53\u7684\u76f8\u5e94\u4e0a\u6e05\u6db2\u5177\u6709100nM T1,100nM T2\u548c100nM T3\u3002<\/p>\n

\uff08E\uff09\u76f8\u5e94\u7684\u5438\u5149\u5ea6\u76f4\u65b9\u56fe\u3002<\/p>\n

Figure 13.<\/strong>\u77f3\u58a8\u70ef<\/strong>–<\/strong>\u91d1\u8868\u9762\u7ed3\u6784\u7684\u8bbe\u8ba1<\/strong><\/p>\n

\"\"<\/p>\n

\uff08A\uff09\u5728\u91d1\u8868\u9762\u4e0a\u6c89\u79ef\u4e00\u5c42\u77f3\u58a8\u70ef\u7684\u57fa\u672c\u7ed3\u6784\u3002\u4e3a\u4e86\u5728\u77f3\u58a8\u70ef-\u91d1\u754c\u9762\u4e0a\u6fc0\u53d1\u8868\u9762\u7b49\u79bb\u5b50\u4f53\u6fc0\u5143\uff0c\u5149\u675f\u901a\u5e38\u7a7f\u8fc7\u73bb\u7483\u68f1\u955c\u5e76\u4ece\u6c89\u79ef\u5728\u5176\u4e00\u4e2a\u523b\u9762\u4e0a\u768450nm\u91d1\u819c\u53cd\u5c04\u3002<\/p>\n

\uff08B\uff09\u5148\u8fdb\u7684\u7eb3\u7c73\u7c92\u5b50\u589e\u5f3a\u7ed3\u6784\uff0c\u4f7f\u7528Au\u7eb3\u7c73\u7c92\u5b50\u4f5c\u4e3aSPR\u653e\u5927\u6807\u7b7e\u3002<\/p>\n

\uff08C\uff09\u5171\u632f\u5355\u5c42\u77f3\u58a8\u70ef\u6d82\u5c42Au\u4f20\u611f\u819c\u7684\u6709\u9650\u5143\u5206\u6790\uff08FEA\uff09\u6a21\u62df\uff1ay\u5206\u91cf\u4e2d\u7684\u7535\u573a\uff0c\u663e\u793a\u5165\u5c04\u5149\u7684\u89d2\u5ea6\u224852\u00b0\uff0c\u5e76\u4e14\u5728\u4f20\u611f\u754c\u9762\u5904\u5177\u6709\u6e05\u6670\u7684\u6e10\u901d\u573a\u3002<\/p>\n

\uff08D\uff09\u5171\u632f\u7403\u5f62Au NP\u8026\u5408\u5230\u5355\u5c42\u77f3\u58a8\u70ef\u6d82\u8986\u7684Au\u611f\u5e94\u819c\u7684FEA\u6a21\u62df\uff1a\u7528Au NP\uff08\u76f4\u5f84\u4e3a30nm\uff0c\u8ddd\u611f\u6d4b\u819c\u7684\u8ddd\u79bb\u4e3a5nm\uff09\u7684\u7535\u5bfc\u4f53\u7684\u6807\u51c6\u3002<\/p>\n

\uff08E\uff09\u6cbf\u7740y = 0\u7684\u603b\u7535\u573a\u7684\u622a\u9762\u56fe\uff0c\u5177\u6709\u4e0d\u540c\u6570\u91cf\u7684\u77f3\u58a8\u70ef\u5c42L.<\/p>\n

Figure 14.HFs-GOx<\/strong>\u7eb3\u7c73\u590d\u5408\u6750\u6599\u5728<\/strong>GCE<\/strong>\u8868\u9762\u4e0a\u5b98\u80fd\u5316\u5e76\u7528\u4e00\u5c42\u58f3\u805a\u7cd6\u819c\u949d\u5316<\/strong><\/p>\n

\"\"<\/p>\n

\uff08A\uff09HFs-GOx\u7684\u7ed3\u6784\u3002<\/p>\n

\uff08B\uff09\u542b\u6709HFs-GOx\u7684\u88c5\u7f6e\u7684\u7ed3\u6784\uff0c\u5176\u7528\u4e00\u5c42\u58f3\u805a\u7cd6\u819c\u949d\u5316\u3002<\/p>\n

\uff08C\uff09\u54cd\u5e94\u7535\u6d41\u5bf9\u8461\u8404\u7cd6\u6d53\u5ea6\u7684\u56fe\u3002<\/p>\n

\uff08D\uff09Lineweaver-Burk\u56fe\u3002<\/p>\n

Figure 15.<\/strong>\u5728\u67d4\u6027\u805a\u5bf9\u82ef\u4e8c\u7532\u9178\u4e59\u4e8c\u9187\u916f\uff08<\/strong>PET<\/strong>\uff09\u57fa\u677f\u4e0a\u5236\u9020\u548c\u56fe\u6848\u5316<\/strong>rGO<\/strong>\u4ee5\u6784\u5efa<\/strong>FET<\/strong>\u4f20\u611f\u5668<\/strong><\/p>\n

\"\"<\/p>\n

\uff08A\uff09\u5728\u805aL-\u8d56\u6c28\u9178\u5305\u88ab\u7684rGO-PET\u88c5\u7f6e\u4e0a\u751f\u957f\u7684PC12\u7ec6\u80de\u7684\u5149\u5b66\u56fe\u50cf\u3002<\/p>\n

\uff08B\uff09PC12\u7535\u6c60\u548crGO FET\u4e4b\u95f4\u7684\u754c\u9762\u7684\u793a\u610f\u56fe\u3002<\/p>\n

\uff08C\uff09rGO-PET FET\u5bf9\u7531\u9ad8K+\u6eb6\u6db2\u523a\u6fc0\u7684PC12\u7ec6\u80de\u7684\u513f\u8336\u915a\u80fa\u7684\u56ca\u6ce1\u5206\u6ccc\u7684\u5b9e\u65f6\u54cd\u5e94\uff0cVds = 100mV\u548cVg = 0V\u3002<\/p>\n

Figure 16.<\/strong>\u8461\u8404\u7cd6\u4f20\u611f\u5668<\/strong><\/p>\n

\"\"<\/p>\n

\uff08A\uff09RGO-GOx\u590d\u5408\u6750\u6599\u5236\u9020\u7684\u793a\u610f\u56fe\u3002<\/p>\n

\uff08B\uff09\u542b\u6709\u4e0d\u540c\u8461\u8404\u7cd6\u6d53\u5ea6\u6c34\u5e73\u7684\u6c27\u9971\u548cPBS\u4e2dGCE\/RGO-GOx\u7684\u5faa\u73af\u4f0f\u5b89\u56fe\u3002<\/p>\n

Figure 17.<\/strong>\u5176\u4ed6\u57fa\u4e8e\u78b3\u6750\u6599\u7684\u4f20\u611f\u5668<\/strong><\/p>\n

\"\"<\/p>\n

\uff08A\uff09\u4e0e\u7b14\u8bb0\u672c\u7535\u8111\u6216PDA\u4e92\u8fde\u7684\u9065\u6d4b\u8bbe\u5907\u7684\u793a\u610f\u56fe\u3002<\/p>\n

\uff08B\uff09\u7528\u5bcc\u52d2\u70ef\u6216\u7eb3\u7c73\u7ba1\u5b98\u80fd\u5316\u7684\u4f20\u611f\u5668\u7684\u793a\u610f\u56fe\u3002<\/p>\n

Figure 18.<\/strong>\u57fa\u4e8e<\/strong>CQD<\/strong>\u7684\u4f20\u611f\u5668<\/strong><\/p>\n

\"\"<\/p>\n

\uff08A\uff09\u57fa\u4e8eCQD\u7684\u805a\u96c6\u548c\u89e3\u805a\u7684\u7126\u78f7\u9178\u6839\u9634\u79bb\u5b50\u548cALP\u6d3b\u6027\u7684\u68c0\u6d4b\u7b56\u7565\u7684\u793a\u610f\u56fe\u3002<\/p>\n

\uff08B\uff09\u968f\u7740Cu2+<\/sup>\u91cf\u7684\u589e\u52a0\uff0cCQD\u7684\u8367\u5149\u54cd\u5e94<\/p>\n

\uff08C\uff09CQD\u548cCu 2+\u6df7\u5408\u7269\u968f\u7740\u7126\u78f7\u9178\u6839\u9634\u79bb\u5b50\u6d53\u5ea6\u589e\u52a0\u7684\u8367\u5149\u54cd\u5e94\u3002<\/p>\n

Figure 19.<\/strong>\u80bd\u529f\u80fd\u5316\u7684<\/strong>GO<\/strong>\u4f5c\u4e3a\u8367\u5149\u6210\u50cf\u6807\u8bb0<\/strong><\/p>\n

\"\"<\/p>\n

\uff08A\uff09\u4f7f\u7528GO-\u80bd\u7f00\u5408\u7269\u68c0\u6d4b\u80f1\u5929\u86cb\u767d\u9176-3\u7684\u793a\u610f\u56fe\u3002<\/p>\n

\uff08B\uff09\u5236\u5907GO-\u80bd\u7f00\u5408\u7269\u7684\u793a\u610f\u56fe\u3002AFM\u548c\uff08C\uff09GO\u548c\uff08D\uff09GO-\u80bd\u7f00\u5408\u7269\u7684\u9ad8\u5ea6\u5206\u5e03\u3002<\/p>\n

Figure 20.<\/strong>\u77f3\u58a8\u70ef\u7eb3\u7c73\u63a2\u9488<\/strong><\/p>\n

\"\"<\/p>\n

\uff08A\uff09\u4f7f\u7528\u5fae\u6ce2\u52a0\u70ed\u8d85\u58f0\u8f85\u52a9\u5de5\u827a\u5236\u5907\u77f3\u58a8\u70ef\u7eb3\u7c73\u63a2\u9488\u7684\u793a\u610f\u56fe\uff0c\u4ee5\u53ca\u4e19\u70ef\u9178\u548c\u7532\u57fa\u4e19\u70ef\u9178\u8367\u5149\u7d20\u7684\u8868\u9762\u6539\u6027\u3002<\/p>\n

\uff08B-G\uff09\u5bf9\u7167\uff08\u4e0a\u6392\uff09\u548c\u5904\u7406\uff08\u4e0b\u6392\uff09HeLa\u7ec6\u80de\u7684CLSM\u56fe\u50cf\u3002<\/p>\n

\uff08B\uff0cE\uff09\u662f\u4f7f\u7528DAPI\u6ee4\u6ce2\u5668\u62cd\u6444\u7684\u6838\u56fe\u50cf\u3002<\/p>\n

\uff08C\uff0cF\uff09\u662f\u6765\u81ea\u7528FITC\u6ee4\u6ce2\u5668\u8bb0\u5f55\u7684\u77f3\u58a8\u70ef\u7684\u7eff\u8272\u8367\u5149\u56fe\u50cf\u3002<\/p>\n

\uff08D\uff0cG\uff09\u662f\u6838\u56fe\u50cf\u548c\u7eff\u8272\u8367\u5149\u56fe\u50cf\u7684\u91cd\u53e0\u56fe\u50cf\u3002<\/p>\n

Figure 21.<\/strong>\u591a\u529f\u80fd\u7eb3\u7c73\u63a2\u9488<\/strong><\/p>\n

\"\"<\/p>\n

\uff08A\uff09\u591a\u529f\u80fd\u7eb3\u7c73\u63a2\u9488\u7684\u5236\u5907\u793a\u610f\u56fe\u3002<\/p>\n

\uff08B\uff09\u6d3b\u7ec6\u80de\u7684\u78c1\u573a\u5f15\u5bfcSERS-\u8367\u5149\u6210\u50cf\u7684\u793a\u610f\u56fe\u3002<\/p>\n

\uff08C\uff09\u8367\u5149\u56fe\u50cf\uff0c\uff08D\uff09SERS\u56fe\u50cf\uff0c\uff08E\uff09\u4eae\u573a\uff0c\u548c\uff08F\uff09\u6765\u81ea\u75284ATP\u7f16\u7801\u7684\u7eb3\u7c73\u63a2\u9488\u5b75\u80b2\u7684SKBR3\u7ec6\u80de\u7684SERS\u5149\u8c31\u3002<\/p>\n

\uff08G\uff09\u8367\u5149\u56fe\u50cf\uff0c\uff08H\uff09SERS\u56fe\u50cf\uff0c\uff08I\uff09\u4eae\u573a\uff0c\u548c\uff08J\uff09\u6765\u81ea\u75284ATP\u7f16\u7801\u7684\u7eb3\u7c73\u63a2\u9488\u5b75\u80b2\u7684MCF7\u7ec6\u80de\u7684SERS\u5149\u8c31\u3002<\/p>\n

Figure 22.CdSe\/ZnS QDs<\/strong>\u5728\u6210\u50cf\u4e0a\u7684\u5e94\u7528<\/strong><\/p>\n

\"\"<\/p>\n

\uff08A\uff09\u63cf\u8ff0SWNH\u4e0eCdSe\/ZnS QDs\u7684\u7f00\u5408\u7684\u793a\u610f\u56fe\u3002<\/p>\n

\uff08A,B,D\uff09\u5728\u6ca1\u6709\u7eb3\u7c73\u63a2\u9488\u7684\u60c5\u51b5\u4e0bRENCA\u7ec6\u80de\u548c\u4e0e\u7eb3\u7c73\u63a2\u9488\u5b75\u80b224\u5c0f\u65f6\u540e\u7684\u76f8\u5dee\u56fe\u50cf\u3002<\/p>\n

(C,F)\u6ca1\u6709\u7eb3\u7c73\u63a2\u9488\u7684RENCA\u7ec6\u80de\u4e0e\u7eb3\u7c73\u63a2\u9488\u5b75\u80b224\u5c0f\u65f6\u540e\u7684\u8367\u5149\u56fe\u50cf\u3002\u5728\u6ca1\u6709\u7eb3\u7c73\u63a2\u9488\u7684\u60c5\u51b5\u4e0b\u91cd\u53e0\u76f8\u5dee\u56fe\u50cf\u548c\u8367\u5149\u56fe\u50cf\uff08C\uff09\uff0c\u5e76\u4e14\u5728\u7528\u7eb3\u7c73\u63a2\u9488\u5b75\u80b224\u5c0f\u65f6\u540e\u91cd\u53e0\uff08F\uff09\u3002<\/p>\n

Figure 23.<\/strong>\u7ec6\u80de\u6210\u50cf\u8868\u5f81<\/strong><\/p>\n

\"\"<\/p>\n

\uff08A\uff09\u901a\u8fc7DIC\/epi\u8367\u5149\u663e\u5fae\u955c\u89c2\u5bdfND\u6807\u8bb0\u7684Hela\u7ec6\u80de\u7684\u7ec6\u80de\u5468\u671f\u7684ND\u3002\u7ec6\u80de\u6838\u7528Hoechst 33342\u67d3\u8272\uff0c\u7ea2\u8272\u53d1\u5c04\u6765\u81eaND\u3002<\/p>\n

\uff08B\uff09ND\u548c\u7fa7\u57fa\u8367\u5149\u7d20\u7425\u73c0\u9170\u4e9a\u80fa\u916f\u4f5c\u4e3a\u957f\u671f\u7ec6\u80de\u8ffd\u8e2a\u5242\u7684\u6bd4\u8f83\u7814\u7a76\u3002\u5728\u4e0d\u540c\u7684\u5b75\u80b2\u65f6\u95f4\u5185ND\u548cCDSE\u5b75\u80b2\u76843T3-L1\u7ec6\u80de\u7684\u6d41\u5f0f\u7ec6\u80de\u672f\u7ed3\u679c\u3002<\/p>\n

Figure 24.<\/strong>\u78b3\u70b9\u5728\u6210\u50cf\u4e0a\u7684\u5e94\u7528<\/strong><\/p>\n

\"\"<\/p>\n

\uff08A\uff09TEM\u56fe\u50cf\u548c\uff08B\uff09CD\u7684DLS\u5206\u5e03\u3002<\/p>\n

\uff08C\uff09\u5728\u4e0d\u540c\u6ce2\u957f\uff08320-500nm\uff09\u4e0b\u6fc0\u53d1\u65f6C\u70b9\u7684\u6fc0\u53d1\u4f9d\u8d56\u6027\u3002\u63d2\u56fe\u5206\u522b\u662f\u5728\u5f3a\u5149\u548cUV\u7167\u5c04\u4e0b\u7684C\u70b9\u6eb6\u6db2\u3002<\/p>\n

\uff08D\uff09\u7528\u4e0d\u540c\u6d53\u5ea6\u7684C\u70b9\u5b75\u80b26\u5c0f\u65f6\u540e2\uff05\u7ea2\u7ec6\u80de\u7684\u6eb6\u8840\u7387\u3002<\/p>\n

\uff08E\uff09\u7528\u4e0d\u540c\u6d53\u5ea6\u7684C\u70b9\u5b75\u80b224\u5c0f\u65f6\u540eC6\u7ec6\u80de\u7684\u7ec6\u80de\u6d3b\u529b\u3002<\/p>\n

\uff08F\uff09\u4f7f\u7528C6\u7ec6\u80de\u4f5c\u4e3a\u7ec6\u80de\u6a21\u578b\uff0c\u5728\u4e0d\u540c\u65f6\u95f4\u7ec6\u80de\u6444\u53d6\u4e0d\u540c\u6d53\u5ea6\u7684C\u70b9\u3002<\/p>\n

\uff08G\uff09\u5b75\u80b215\u5206\u949f\u548c4\u5c0f\u65f6\u540eC-\u70b9\u4e0e\u5185\u4f53\u7684\u4e9a\u7ec6\u80de\u5b9a\u4f4d\u3002<\/p>\n

Figure 25.PEG-BPEI-rGO<\/strong>\u7684\u5e94\u7528<\/strong><\/p>\n

\"\"<\/p>\n

\uff08A\uff09PEG-BPEI-rGO\u7684\u5408\u6210\u548c\u6539\u6027\u7684\u793a\u610f\u56fe\u3002<\/p>\n

\uff08B\uff09\u5728NIR\u7167\u5c04\u4e0bGO\uff0cPEG-BPEI-rGO\u548cPEG-BPEI-rGO\/DOX\u6eb6\u6db2\u7684\u6e29\u5ea6\u3002<\/p>\n

\uff08C\uff09\u5728\u9ed1\u6697\u548cNIR\u7167\u5c04\u4e0b\u7528\u4e0d\u540c\u6d53\u5ea6\u7684PEG-BPEI-rGO\u5b75\u80b2\u7684PC-3\u548cHeLa\u7ec6\u80de\u7684\u7ec6\u80de\u6d3b\u529b\u3002<\/p>\n

Figure 26.<\/strong>\u8f7d\u836f\u4e2d\u7684\u5e94\u7528<\/strong><\/p>\n

\"\"<\/p>\n

\uff08A\uff09\u63cf\u8ff0\u5728MWCNT-PVA\u4e0a\u8d1f\u8f7dCPT\u7684\u793a\u610f\u56fe\u3002<\/p>\n

\uff08B\uff09\u5177\u6709\u4e0d\u540c\u6d53\u5ea6\u7684MWCNT-PVA\u548cMWCNT-PVA-CPT\u7684UV\u5149\u8c31\u3002<\/p>\n

\uff08C\uff09\u5728\u4e0d\u540c\u6d53\u5ea6\u4e0b\u7528\u6e38\u79bbCPT\uff0cMWCNT PVA-CPT\u548cGO-PVA-CPT\u57f9\u517b\u7684MDA-MB-231\u7ec6\u80de\u7684\u7ec6\u80de\u6d3b\u6027\u3002<\/p>\n

\uff08D\uff09\u5206\u522b\u7528\u548c\u4e0d\u7528CPT\u7684MWCNT-PVA\u548cGO-PVA\u57f9\u517b\u7684MDA-MB-231\u7ec6\u80de\u7684\u7ec6\u80de\u6d3b\u6027\u3002<\/p>\n

\uff08F\uff09\u7528CPT\uff0cMWCNT-PVA-CPT\u548cGO-PVA-CPT\u5904\u7406\u540e\u7684MDA-MP-231\u7ec6\u80de\u7684\u663e\u5fae\u955c\u56fe\u50cf\u3002<\/p>\n

Figure 27.<\/strong>\u5bcc\u52d2\u70ef\u57fa\u805a\u96c6\u4f53\u7528\u4e8e\u8f7d\u836f<\/strong><\/p>\n

\"\"<\/p>\n

\uff08A\uff09\u5177\u6709\u53cc\u91cd\u764c\u75c7\u4f5c\u7528\u7684\u5bcc\u52d2\u70ef\u57fa\u805a\u96c6\u4f53\u7684\u793a\u610f\u56fe\u3002\u63d2\u56feA\u662fDOX-\u80bc-\u5bcc\u52d2\u70ef\u9187-FA-\u805a\u96c6\u4f53\u7684HRTEM\u56fe\u50cf\u3002\u63d2\u56feB\u662fHeLa\u7ec6\u80de\u7684\u8367\u5149\u663e\u5fae\u955c\uff0c\u5176\u4e2dDOX\u5df2\u4ece\u7eb3\u7c73\u8f7d\u4f53\u91ca\u653e\u3002<\/p>\n

\uff08B\uff09\u7528DOX\uff0cDOX-\u8159-\u5bcc\u52d2\u70ef\u9187-FA\u548cDOX-\u8159-\u5bcc\u52d2\u70ef\u9187\u9897\u7c92\u5904\u7406\u7684HeLa\uff08\u4e0a\u56fe\uff09\uff0cL929\uff08\u4e2d\u56fe\uff09\u548cA549\uff08\u4e0b\u56fe\uff09\u7684\u7ec6\u80de\u6d3b\u6027\u3002<\/p>\n

Figure 28.<\/strong>\u8f7d\u836f\u4e2d\u7684\u5e94\u7528<\/strong><\/p>\n

\"\"<\/p>\n

\uff08A,B\uff09\u4f7f\u7528DLS\u6d4b\u91cf\u7684DCA-HPCHS\uff0cDOX\/DCA-HPCHS\uff0cSWNH\/DCA-HPCHS\u548cDOX-SWNH \/ DCA-HPCHS\u7684\u5c3a\u5bf8\u5206\u5e03\u548c\u5438\u6536\u5149\u8c31\u3002<\/p>\n

\uff08C,D\uff09\u7528SWNH\/DCA-HPCHS\u548cDOX-SWNH\/DCA-HPCHS\u5904\u7406\u76844T1\u7ec6\u80de\u7684\u7ec6\u80de\u5b58\u6d3b\u7387\u3002<\/p>\n

Figure 29.<\/strong>\u7528\u67d3\u6599\u6807\u8bb0\u7684\u836f\u7269<\/strong>-DNA<\/strong>\u5be1\u6838\u82f7\u9178\u5bf9<\/strong>ND<\/strong>\u8868\u9762\u8fdb\u884c\u529f\u80fd\u5316\uff0c\u4ee5\u5b9e\u73b0\u591a\u6a21\u5f0f\u764c\u75c7\u6cbb\u7597\u548c\u589e\u5f3a\u6297\u764c\u6548\u679c<\/strong><\/p>\n

\"\"<\/p>\n

\uff08A\uff09PTX-DNA\/mAb@NDs\u7684\u5236\u5907\u793a\u610f\u56fe\u3002<\/p>\n

\uff08B\uff09\u4f7f\u7528DLS\u6d4b\u91cf\u7684ND\u7684\u6d41\u4f53\u52a8\u529b\u5b66\u5c3a\u5bf8\u53ca\u5176\u7f00\u5408\u7269\u3002<\/p>\n

\uff08C\uff09\u4f7f\u7528\u6d41\u5f0f\u7ec6\u80de\u672f\u5206\u6790\u5bf9MCF7\u548cMDA-B-231\u7ec6\u80de\u4e2d\u7684PTX-DNA@ND\u548cPTX-DNA\/mAb@ND\u8fdb\u884c\u5b9a\u91cf\u5206\u6790\u3002<\/p>\n

\uff08D,E\uff09\u7528PTX\uff0cPTX-DNA@ND\u548cPTX-DNA\/mAb@ND\u5904\u740648\u5c0f\u65f6\u7684MCF-7\u548cMDA-MB-231\u7ec6\u80de\u7684\u7ec6\u80de\u6d3b\u6027\u3002<\/p>\n

Figure 30.<\/strong>\u78b3\u70b9\u5728\u6210\u50cf\u548c\u8f7d\u836f\u4e2d\u7684\u5e94\u7528<\/strong><\/p>\n

\"\"<\/p>\n

Figure 31.<\/strong>\u591a\u529f\u80fd\u7535\u8377\u53ef\u8f6c\u6362\u7eb3\u7c73\u590d\u5408\u6750\u6599\u7684\u5408\u6210\u548c\u53d7\u6fc0\u54cd\u5e94\u7684\u793a\u610f\u56fe<\/strong><\/p>\n

\"\"<\/p>\n

Figure 32.SWCNT<\/strong>\u8367\u5149\u7eb3\u7c73\u63a2\u9488\u7528\u4e8e\u591a\u6a21\u5f0f\u4f53\u5185\u6210\u50cf\u5f15\u5bfc\u5149\u70ed\u6cbb\u7597\u524d\u54e8\u6dcb\u5df4\u7ed3\u80bf\u7624<\/strong><\/p>\n

\"\"<\/p>\n

\uff08A\uff09\u52a8\u7269\u5b9e\u9a8c\u8bbe\u8ba1\u7684\u793a\u610f\u56fe\u3002<\/p>\n

\uff08B\uff09\u5728\u6ce8\u5c04SWCNT-PEG\u540e\u4ee5\u4e0d\u540c\u95f4\u9694\u6444\u53d6\u7684\u8377\u7624\u5c0f\u9f20\u7684NIR II\u8303\u56f4\u5185\u7684\u8367\u5149\u6210\u50cf\u3002<\/p>\n

\uff08C\uff09\u5c0f\u9f20\u7684\u7ea2\u5916\u70ed\u56fe\u50cf\u3002<\/p>\n

Figure 33.<\/strong>\u78b3\u7eb3\u7c73\u7ba1\u7528\u4e8e\u80bf\u7624\u6cbb\u7597<\/strong><\/p>\n

\"\"<\/p>\n

\uff08A\uff09\u63cf\u8ff0\u81ea\u653e\u5927\u9776\u5411\u7cfb\u7edf\u673a\u5236\u7684\u793a\u610f\u56fe\u3002<\/p>\n

\uff08B\uff09\u9759\u8109\u5185\u6ce8\u5c044mg\/kg CMWCNTs-PEG\u5e76\u5728\u65bd\u7528\u540e\u7528808nm NIR\u6fc0\u5149\u5904\u7406\u7684\u5c0f\u9f20\u6a21\u578b\u7684\u80bf\u7624\u6e29\u5ea6\u968f\u65f6\u95f4\u7684\u53d8\u5316\u3002<\/p>\n

\uff08C\uff09\u5728\u75284mg\/kg MWCNT\u5904\u7406\u7684\u8377\u7624\u5c0f\u9f20\u6a21\u578b\u4e2d\u4f5c\u4e3aNIR\u5149\u7167\u5c04\u65f6\u95f4\u7684\u51fd\u6570\u7684\u7ea2\u5916\u70ed\u56fe\u50cf\u3002<\/p>\n

Figure 34.<\/strong>\u4f7f\u7528\u57fa\u4e8e\u6df7\u5408\u78b3\u70b9\u7684\u591a\u529f\u80fd\u6cbb\u7597\u8bca\u65ad\u7eb3\u7c73\u5e73\u53f0\u8fdb\u884c\u80bf\u7624\u7279\u5f02\u6027\u57fa\u56e0\u8f6c\u79fb<\/strong><\/p>\n

\u00a0\"\"<\/strong><\/p>\n

\uff08A\uff09\u57288\u5c0f\u65f6\u540e\u901a\u8fc7\u80bf\u7624\u5185\u6ce8\u5c04\uff08\u5de6\uff09\u548c\u9759\u8109\u6ce8\u5c04\uff08\u53f3\uff09\u6ce8\u5c04PPD@HPAP-CDs\/pDNA\u540e\u8377\u7624\u5c0f\u9f20\u7684\u4f53\u5185\u6210\u50cf\u3002<\/p>\n

\uff08B\uff09\u9759\u8109\u5185\u6ce8\u5c04\u4e0d\u540c\u5236\u5242\u548c\u5b9a\u91cf\u5206\u5e03\u5206\u6790\u540e\uff0c\u5728\u80bf\u7624\u7ec4\u7ec7\u4e2dHPAP-CDs\/ pDNA\u590d\u5408\u7269\u79ef\u805a\u7684\u79bb\u4f53\u6210\u50cf\u3002<\/p>\n

\uff08C\uff098\u5c0f\u65f6\u540e\u7528\u4e0d\u540c\u5236\u5242\u9759\u8109\u6ce8\u5c04\u540e\u6536\u83b7\u7684\u4e3b\u8981\u5668\u5b98\u7684\u79bb\u4f53\u6210\u50cf\u53ca\u5176\u76f8\u5e94\u7684\u8367\u5149\u5b9a\u91cf\u6570\u636e\u3002PPD@HPAP-CDs\/pTRAIL\u548c\u5176\u4ed6\u5236\u5242\u5728\u643a\u5e26MCF-7\u7ec6\u80de\u7684\u88f8\u9f20Balb\/c\u5c0f\u9f20\u4e2d\u7684\u4f53\u5185\u6297\u80bf\u7624\u7814\u7a76\uff08D\uff09\u80bf\u7624\u4f53\u79ef\u5206\u5e03\u548c\uff08E\uff09\u5e73\u5747\u4f53\u91cd\u53d8\u5316\u3002<\/p>\n

\uff08F\uff09\u6765\u81ea\u88f8\u9f20\u7684\u80bf\u7624\u7ec4\u7ec7\u56fe\u50cf\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

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Nanocarbons for Biology and Medicine: Sensing, Imaging, and Drug Delivery<\/a><\/p>\n

(Chem. Rev., 2019, DOI: 10.1021\/acs.chemrev.9b00099)<\/p>\n

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\u7814\u7a76\u65b9\u5411
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