{"id":184993,"date":"2019-09-06T06:30:32","date_gmt":"2019-09-05T22:30:32","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=184993"},"modified":"2019-09-04T18:10:13","modified_gmt":"2019-09-04T10:10:13","slug":"%e5%b7%b2%e6%a0%a1%e7%a8%bf%e4%bb%b6-adv-mater-%e6%8a%a5%e9%81%93-%e5%88%a9%e7%94%a8%e5%85%89%e8%af%b1%e5%af%bc%e7%ba%b3%e7%b1%b3%e9%a2%97%e7%b2%92%e8%87%aa%e5%a2%9e%e5%bc%ba%e8%8d%af%e7%89%a9","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=184993","title":{"rendered":"\u4e2d\u79d1\u9662\u4e0a\u6d77\u836f\u7269\u7814\u7a76\u6240Adv. Mater.: \u5229\u7528\u5149\u8bf1\u5bfc\u7eb3\u7c73\u9897\u7c92\u81ea\u589e\u5f3a\u836f\u7269\u9012\u9001\u6765\u589e\u5f3a\u764c\u75c7\u7684\u514d\u75ab\u6cbb\u7597"},"content":{"rendered":"<p><strong>\u3010\u80cc\u666f\u4ecb\u7ecd\u3011<\/strong><\/p>\n<p>\u4f17\u6240\u5468\u77e5\uff0c\u9488\u5bf9PD-L1\u6216PD-1\u7684\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\uff08ICB\uff09\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u5df2\u7ecf\u5728\u4e34\u5e8a\u4e0a\u53d6\u5f97\u663e\u8457\u6210\u529f\u5e76\u53d7\u5230\u5e7f\u6cdb\u5173\u6ce8\u3002\u7136\u800c\uff0c\u7531\u4e8e\u5bf9ICB\u6cbb\u7597\u7684\u5185\u5728\u6297\u6027\uff0c\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u5b58\u5728\u54cd\u5e94\u7387\u4f4e\u548c\u6cbb\u7597\u529f\u6548\u6709\u9650\u7684\u7f3a\u70b9\u3002\u5176\u4e2d\uff0c\u514d\u75ab\u6291\u5236\u80bf\u7624\u5fae\u73af\u5883\uff08ITM\uff09\u662f\u5bfc\u81f4ICB\u6cbb\u7597\u8010\u53d7\u7684\u4e3b\u8981\u539f\u56e0\u3002\u5c3d\u7ba1\u963f\u9709\u7d20\uff08DOX\uff09\u7b49\u5316\u7597\u836f\u7269\u3001PDT\u548cPTT\u7b49\u6cbb\u7597\u624b\u6bb5\u4e5f\u53ef\u4ee5\u8bf1\u5bfc\u80bf\u7624\u7ec6\u80de\u7684\u514d\u75ab\u539f\u6027\u7ec6\u80de\u6b7b\u4ea1\uff08ICD\uff09\uff0c\u5f15\u53d1\u514d\u75ab\u5e94\u7b54\u3002\u4f46\u662fITM\u548c\u9002\u5e94\u6027\u514d\u75ab\u6297\u6027\u4e25\u91cd\u6291\u5236ICD\u6fc0\u53d1\u7684\u7ea7\u8054\u6297\u80bf\u7624\u514d\u75ab\u6548\u5e94\u3002<\/p>\n<p><strong>\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n<p>\u6700\u8fd1\uff0c<strong>\u4e2d\u56fd\u79d1\u5b66\u9662\u4e0a\u6d77\u836f\u7269\u7814\u7a76\u6240\u4e8e\u6d77\u519b\u7814\u7a76\u5458\u548c\u674e\u4e9a\u5e73\u7814\u7a76\u5458<\/strong>\u8054\u5408\u62a5\u9053\u4e86\u4e00\u79cd\u7528\u4e8e\u514d\u75ab\u6cbb\u7597\u7684\u5149\u8bf1\u5bfc\u7eb3\u7c73\u9897\u7c92\uff08LINC\uff09\u3002\u5176\u4e2d\uff0cLINC\u7531\u5149\u654f\u5242\u8131\u9541\u53f6\u7eff\u7d20A\uff08PPa\uff09\u3001\u5432\u54da\u80fa-2\uff0c3-\u53cc\u52a0\u6c27\u9176-1\uff08IDO-1\uff09\u6291\u5236\u5242\uff08NLG919\uff09\u4e8c\u805a\u4f53\u548c\u5965\u6c99\u5229\u94c2\uff08OXA\uff09\u524d\u836f\u7ec4\u6210\u3002\u901a\u8fc7\u9759\u8109\u5185\u6ce8\u5c04\u7684LINC\u79ef\u805a\u5728\u80bf\u7624\u90e8\u4f4d\u4ee5\u4ea7\u751f\u8fd1\u7ea2\u5916\uff08NIR\uff09\u8367\u5149\u4fe1\u53f7\u3002\u5728\u8367\u5149\u6210\u50cf\u6307\u5bfc\u4e0b\uff0c\u8fdb\u884c\u7b2c\u4e00\u6b21\u8fd1\u7ea2\u5916\u6fc0\u5149\u7167\u5c04\u8bf1\u5bfc\u4ea7\u751f\u6d3b\u6027\u6c27\uff08ROS\uff09\u5bfc\u81f4\u805a\u4e59\u4e8c\u9187\uff08PEG\uff09\u88c2\u89e3\uff0c\u4fc3\u8fdb\u7eb3\u7c73\u7c92\u5b50\u5728\u80bf\u7624\u5904\u7684\u6ede\u7559\u548c\u6df1\u5ea6\u7a7f\u900f\u3002\u7b2c\u4e8c\u6b21NIR\u6fc0\u5149\u7167\u5c04\u65f6\uff0cLINC\u6709\u6548\u5730\u5f15\u53d1\u514d\u75ab\u5e94\u7b54\u5e76\u4fc3\u8fdb\u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de\uff08CTL\uff09\u7684\u80bf\u7624\u5185\u6d78\u6da6\u3002\u6b64\u5916\uff0cLINC\u9012\u9001\u7684NLG919\u53ef\u6709\u6548\u6291\u5236IDO-1\u6d3b\u6027\uff0c\u9006\u8f6c\u514d\u75ab\u6291\u5236\u6027\u80bf\u7624\u5fae\u73af\u5883\u3002LINC\u4ecb\u5bfc\u7684\u5316\u5b66\u514d\u75ab\u7597\u6cd5\u6291\u5236\u80bf\u7624\u751f\u957f\u3001\u80ba\u8f6c\u79fb\u548c\u80bf\u7624\u590d\u53d1\u3002\u8be5\u7814\u7a76\u65b9\u6cd5\u4e3a\u6539\u5584\u836f\u7269\u9012\u9001\u548c\u514d\u75ab\u7597\u6cd5\u7684\u5149\u8bf1\u5bfc\u81ea\u653e\u5927\u6548\u5e94\u63d0\u4f9b\u4e86\u65b0\u7b56\u7565\u3002\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a<strong>\u201cSelf-Amplified Drug Delivery with Light-Inducible Nanocargoes to Enhance Cancer Immunotherapy\u201d<\/strong>\u53d1\u5e03\u5728\u56fd\u9645\u8457\u540d\u671f\u520a<strong>Adv. Mater.<\/strong>\u4e0a\u3002<\/p>\n<p><strong>\u3010\u56fe\u6587\u89e3\u8bfb\u3011<\/strong><\/p>\n<p><strong>\u56fe\u4e00\u3001NIR\u8bf1\u5bfcLINC\u7684\u81ea\u653e\u5927\u836f\u7269\u9012\u9001\u548c\u7ec4\u5408\u514d\u75ab\u7597\u6cd5\u793a\u610f\u56fe<\/strong><br \/>\n <img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-184994\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/09\/1.jpg\" alt=\"\" width=\"600\" height=\"565\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/09\/1.jpg 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/09\/1-300x283.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" 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loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-184997\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/09\/4.jpg\" alt=\"\" width=\"600\" height=\"505\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/09\/4.jpg 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/09\/4-300x253.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" 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href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/adma.201902960\" target=\"_blank\" rel=\"noopener\">Self-Amplified Drug Delivery with Light-Inducible Nanocargoes to Enhance Cancer Immunotherapy<\/a><\/strong>\uff08<em>Adv. Mater.<\/em>, <strong>2019<\/strong>, DOI: 10.1002\/adma.201902960\uff09<\/p>\n<p>\u672c\u6587\u7531CQR\u7f16\u8bd1\u3002<\/p>\n<p>\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1\uff1atougao@cailiaoren.com.<\/p>\n<p>\u6295\u7a3f\u4ee5\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1acailiaokefu.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u80cc\u666f\u4ecb\u7ecd\u3011 \u4f17\u6240\u5468\u77e5\uff0c\u9488\u5bf9PD-L1\u6216PD-1\u7684\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\uff08ICB\uff09\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u5df2\u7ecf\u5728\u4e34\u5e8a\u4e0a\u53d6\u5f97\u663e\u8457\u6210\u529f\u5e76\u53d7\u5230\u5e7f\u6cdb\u5173\u6ce8\u3002\u7136\u800c\uff0c\u7531\u4e8e\u5bf9ICB\u6cbb\u7597\u7684\u5185\u5728\u6297\u6027\uff0c&#8230;<\/p>\n","protected":false},"author":7770,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215,2],"tags":[4177],"class_list":["post-184993","post","type-post","status-publish","format-standard","hentry","category-jiedu","category-keji","tag-4177"],"_links":{"self":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/184993"}],"collection":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/users\/7770"}],"replies":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=184993"}],"version-history":[{"count":3,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/184993\/revisions"}],"predecessor-version":[{"id":185051,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/184993\/revisions\/185051"}],"wp:attachment":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=184993"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=184993"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=184993"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}