{"id":185498,"date":"2019-09-13T06:30:58","date_gmt":"2019-09-12T22:30:58","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=185498"},"modified":"2019-09-12T10:23:41","modified_gmt":"2019-09-12T02:23:41","slug":"%e3%80%90%e6%8a%95%e7%a8%bf%e3%80%91%e6%9a%a8%e5%8d%97%e5%a4%a7%e5%ad%a6%e9%99%88%e5%a1%ab%e7%83%bd%e5%9b%a2%e9%98%9fsmall%e5%b0%81%e9%9d%a2-%e7%ba%b3%e7%b1%b3%e5%8c%96%e7%81%b5%e8%8a%9d%e5%ad%a2","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=185498","title":{"rendered":"\u66a8\u5357\u5927\u5b66\u9648\u586b\u70fd\u56e2\u961fSmall\u5c01\u9762: \u7eb3\u7c73\u5316\u7075\u829d\u5b62\u5b50\u6cb9\u89e3\u51b3\u653e\u7597\u5f15\u8d77\u7684\u5fc3\u808c\u635f\u4f24"},"content":{"rendered":"

\u653e\u5c04\u7597\u6cd5 (Radiotherapy, RT) \u662f\u4e34\u5e8a\u80bf\u7624\u6cbb\u7597\u7684\u4e09\u5927\u7b56\u7565 (\u624b\u672f\u5207\u9664\uff0c\u5316\u5b66\u836f\u7269\u6cbb\u7597\u548c\u653e\u5c04\u6cbb\u7597) \u4e4b\u4e00\u3002\u4f46\u662f\uff0c\u8fd9\u79cd\u5c04\u7ebf\u5c40\u90e8\u6cbb\u7597\u65b9\u5f0f\u65e0\u660e\u663e\u9009\u62e9\u6027\uff0c\u5bb9\u6613\u5f15\u8d77\u673a\u4f53\u6b63\u5e38\u7ec4\u7ec7\u635f\u4f24\u3002\u5176\u4e2d\uff0c\u5fc3\u810f\u5728\u653e\u7597\u4e0a\u8154\u90e8\u4f4d\u80bf\u7624 (\u5982\u4e73\u817a\u764c\u3001\u98df\u7ba1\u764c\u3001\u80ba\u764c\u3001\u7eb5\u8188\u6dcb\u5df4\u7624\u7b49) \u7684\u8fc7\u7a0b\u4e2d\u6613\u53d7\u5230\u8f90\u5c04\u7275\u8fde\uff0c\u7535\u5b50\u675f\u7167\u5c04\u673a\u4f53\u5f15\u53d1\u8fc7\u591a\u7684\u6c27\u81ea\u7531\u57fa\u4ea7\u751f\uff0c\u5f02\u5e38\u4e0a\u8c03\u673a\u4f53\u7684\u6d3b\u6027\u6c27\u6c34\u5e73 (Reactive oxygen species, ROS), \u635f\u4f24\u7ebf\u7c92\u4f53\u7ed3\u6784\u5f62\u6001\u4e0e\u529f\u80fd\uff0c\u5e76\u8bf1\u53d1\u7ec6\u80de\u5185DNA \u635f\u4f24\uff0c\u8fdb\u800c\u8bf1\u5bfc\u7ec6\u80de\u5468\u671f\u963b\u6ede\u751a\u81f3\u51cb\u4ea1\u3002\u4e25\u91cd\u7684\u6c27\u5316\u5e94\u6fc0\u635f\u4f24\u751a\u81f3\u8bf1\u5bfc\u5fc3\u808c\u7ec6\u80de\u51cb\u4ea1\uff0c\u5f15\u8d77\u540e\u7eed\u7684\u653e\u5c04\u6027\u5fc3\u810f\u75be\u75c5 (Radiation-induced heart disease, RIHD)\uff0c\u5982\u5fc3\u5305\u708e\u3001\u5fc3\u808c\u7ea4\u7ef4\u5316\u548c\u5fc3\u808c\u708e\u7b49\u3002<\/span><\/p>\n

\u7075\u829d\u5b62\u5b50\u6cb9 (Ganoderma lucidum spores oil<\/i><\/em>, GLSO) \u56e0\u7518\u6cb9\u4e09\u916f\u7b49\u6d3b\u6027\u6210\u5206\u8868\u73b0\u6297\u6c27\u5316\u3001\u6297\u708e\u53ca\u63d0\u9ad8\u673a\u4f53\u514d\u75ab\u529b\u7b49\u529f\u6548\u800c\u88ab\u4eba\u4eec\u6240\u8bc6\uff0c\u4f46\u540c\u65f6\u4e5f\u7531\u4e8e\u6613\u6c27\u5316\u53d8\u8d28\u3001\u7a33\u5b9a\u6027\u5dee\u548c\u4f4e\u6eb6\u89e3\u6027\u7b49\u7f3a\u70b9\u800c\u4f7f\u5e94\u7528\u53d7\u9650\u3002\u56e0\u6b64\uff0c\u5408\u7406\u8bbe\u8ba1\u7eb3\u7c73\u4f53\u7cfb\u6765\u63d0\u9ad8\u5b62\u5b50\u6cb9\u7684\u7a33\u5b9a\u6027\u53ca\u6eb6\u89e3\u6027\uff0c\u624d\u53ef\u80fd\u589e\u5f3a\u5176\u751f\u7269\u529f\u6548\u3002\u5728\u672c\u7814\u7a76\u5de5\u4f5c\u4e2d\uff0c\u4f5c\u8005\u8bbe\u8ba1\u4e86\u4e00\u79cd\u751f\u7269\u53ef\u964d\u89e3\u7684\u805a\u5408\u7269\u57fa\u7075\u829d\u5b62\u5b50\u6cb9\u7eb3\u7c73\u4f53\u7cfb(GLSO@P188\/PEG400<\/sub>\u00a0NS)\uff0c\u8fdb\u884c\u4e86\u6297\u8f90\u5c04\u6d3b\u6027\u53ca\u76f8\u5173\u4f5c\u7528\u673a\u5236\u548c\u4fdd\u62a4\u5fc3\u529f\u80fd\u4f5c\u7528\u7b49\u7814\u7a76\uff0c\u9610\u8ff0\u4e86\u7eb3\u7c73\u4f53\u7cfb\u5bf9\u4e8e\u4f4e\u6eb6\u89e3\u5ea6\u7684\u4f20\u7edf\u4e2d\u836f\u6210\u5206\u6709\u6548\u53d1\u6325\u751f\u7269\u529f\u6548\u7684\u4fc3\u8fdb\u4f5c\u7528\u3002\u76f8\u5173\u8bba\u6587\u4e8e\u8fd1\u65e5\u4f5c\u4e3a\u5c01\u9762\u53d1\u8868\u5728Small<\/i><\/b><\/em><\/strong>\u6742\u5fd7\u4e0a\uff08DOI: 10.1002\/smll.201902642\uff09\u3002<\/span><\/p>\n

\u56fe1. \u6587\u7ae0\u5c01\u9762\u4ee5\u53ca\u7eb3\u7c73\u5316\u7075\u829d\u5b62\u5b50\u6cb9\u53d1\u6325\u6297\u8f90\u5c04\u5fc3\u808c\u4fdd\u62a4\u7684\u793a\u610f\u56fe\u3002<\/strong><\/span><\/p>\n

\"\"<\/span><\/p>\n

\u56fe2. \u7075\u829d\u5b62\u5b50\u6cb9\u7eb3\u7c73\u4f53\u7cfb\u7f13\u89e3X\u5c04\u7ebf\u8bf1\u53d1\u7684DNA\u635f\u4f24\u3002<\/strong><\/span><\/p>\n

\"\"<\/span><\/p>\n

(a) \u5b62\u5b50\u6cb9\u7eb3\u7c73\u4f53\u7cfb\u51cf\u8f7b\u5fc3\u808c\u7ec6\u80de\u53d7\u8f90\u5c04\u635f\u4f24\u7684\u4fe1\u53f7\u8f6c\u5bfc\u8bbe\u60f3\u3002(b) \u5b62\u5b50\u6cb9\u7eb3\u7c73\u4f53\u7cfb\u9006\u8f6cX\u5c04\u7ebf\u8bf1\u5bfc\u7684\u7ec6\u80de\u5468\u671f\u963b\u6ede\u73b0\u8c61\u3002(c-d) \u5b62\u5b50\u6cb9\u7eb3\u7c73\u4f53\u7cfb\u8c03\u8282\u7ec6\u80de\u81ea\u6211\u635f\u4f24\u4fee\u590d\u76f8\u5173\u7684\u4fe1\u53f7\u8f6c\u5bfc\u3002(e) \u5b62\u5b50\u6cb9\u7eb3\u7c73\u4f53\u7cfb\u51cf\u5c11X\u5c04\u7ebf\u8bf1\u5bfc\u7684\u03b3-H2<\/sub>A.X\u78f7\u9178\u5316\u7126\u70b9\u53ca\u5176 (f) \u5b9a\u91cf\u5206\u6790\u7ed3\u679c\u3002<\/span><\/p>\n

\u7814\u7a76\u8868\u660e\uff0c\u8be5\u5b62\u5b50\u6cb9\u7eb3\u7c73\u4f53\u7cfb\u80fd\u8c03\u8282\u8f90\u5c04\u6240\u81f4\u7684G0\/G1 \u671f\u963b\u6ede\u5e76\u901a\u8fc7\u8c03\u8282\u76f8\u5173\u4fee\u590d\u86cb\u767d (\u5982XRCC1, HSP70, MGMT \u7b49) \u4ee5\u53ca\u6291\u5236\u76f8\u5173\u7ec6\u80de\u635f\u4f24\u86cb\u767d (PARP, p-Chk1\/2, p-\u03b3 H2<\/sub>A.X \u7b49) \u8868\u8fbe\u6c34\u5e73\uff0c\u6765\u4fc3\u8fdbH9<\/sub>C2<\/sub> \u5fc3\u808c\u7ec6\u80de\u751f\u957f\u3002<\/span><\/p>\n

\u56fe3. \u7075\u829d\u5b62\u5b50\u6cb9\u7eb3\u7c73\u4f53\u7cfb\u6539\u5584X\u5c04\u7ebf\u8f90\u5c04\u5f15\u8d77\u7684\u5fc3\u810f\u635f\u4f24\u3002<\/strong><\/span><\/p>\n

\"\"<\/span><\/p>\n

(a) \u5c0f\u9f20\u63a5\u53d7X\u5c04\u7ebf\u8f90\u7167\u53caM-\u578b\u8d85\u58f0\u5fc3\u52a8\u63cf\u8bb0\u7684\u793a\u610f\u56fe\u3002(b) \u4e8c\u5c16\u74e3\u8109\u51b2\u591a\u666e\u52d2 (PWD) \u77ed\u8f74\u56fe\u8c31\u4fe1\u606f\u7528\u4e8e\u5b9a\u91cf\u5206\u6790\u5c0f\u9f20\u5fc3\u529f\u80fd\u76f8\u5173\u53c2\u6570\u3002\u8f90\u7167\u540e35\u5929\u5185\u68c0\u6d4b\u5c0f\u9f20\u5fc3\u810f\u7684 (c) \u5de6\u5ba4\u5c04\u8840\u5206\u6570\uff0c(d) \u5de6\u5ba4\u77ed\u8f74\u7f29\u77ed\u7387\u548c (e) \u4f53\u91cd\u53d8\u5316\u56fe\u3002\u8f90\u7167\u7b2c35\u5929\u68c0\u6d4b\u5c0f\u9f20\u5fc3\u810f\u7684 (f) \u5de6\u5ba4\u5c04\u8840\u5206\u6570\uff0c(g) \u5de6\u5ba4\u77ed\u8f74\u7f29\u77ed\u7387\uff0c(h) \u5fc3\u529f\u80fdTei\u6307\u6570\u548c (i) \u4f53\u91cd\u53d8\u5316\u7387\u3002(j) \u5fc3\u808c\u7ec6\u80de\u4e2d\u7f1d\u9699\u8fde\u63a5\u86cb\u767dConnexin-43\u7684\u8868\u8fbe\u60c5\u51b5\u53ca\u5176 (k) \u534a\u5b9a\u91cf\u5206\u6790\u3002<\/span><\/p>\n

\u8fdb\u4e00\u6b65\u7814\u7a76\u53d1\u73b0\uff0c\u8be5\u5b62\u5b50\u6cb9\u7eb3\u7c73\u4f53\u7cfb\u7684\u9884\u4fdd\u62a4\u4e0e\u540e\u4fee\u590d\u8054\u5408\u6cbb\u7597\u7b56\u7565\u5bf9\u4e8e\u53d7X \u5c04\u7ebf\u8f90\u7167\u7684\u5c0f\u9f20\u5fc3\u810f\u5177\u6709\u66f4\u5f3a\u7684\u4fdd\u62a4\u4e0e\u635f\u4f24\u4fee\u590d\u4f5c\u7528\uff0c\u5176\u80fd\u591f\u8c03\u8282\u5de6\u5ba4\u5c04\u8840\u5206\u6570 (LVEF) \u548c\u77ed\u8f74\u7f29\u77ed\u7387 (LVFS) \u4ee5\u53caTei \u5fc3\u6307\u6570\u7b49\u53c2\u6570\u6c34\u5e73\uff0c\u6062\u590d\u5fc3\u529f\u80fd\u81f3\u6b63\u5e38\u6c34\u5e73\u3002<\/span><\/p>\n

\u56fe4. \u5b62\u5b50\u6cb9\u7eb3\u7c73\u4f53\u7cfb\u7684\u63d0\u524d\u4fdd\u62a4\u4e0e\u540e\u4fee\u590d\u8054\u5408\u6cbb\u7597\u7b56\u7565\u9006\u8f6cX \u5c04\u7ebf\u8f90\u5c04\u5f15\u8d77\u7684\u5fc3\u808c\u7ea4\u7ef4\u5316\u4e0e\u708e\u75c7\u3002<\/strong><\/span><\/p>\n

\"\"<\/span><\/p>\n

(a) X\u5c04\u7ebf\u8f90\u7167\u540e\u7b2c35\u5929\u5c0f\u9f20\u5fc3\u810f\u7247\u7684\u7ea4\u7ef4\u5316\u5206\u6790\u53ca\u5176\u653e\u5927\u56fe\u50cf (Masson\u67d3\u8272) \u53ca\u5176\u5b9a\u91cf\u5206\u6790\u7ed3\u679c (b)\u3002(c) \u4e0d\u540c\u7684\u63d0\u524d\u4fdd\u62a4\u4e0e\u540e\u4fee\u590d\u8054\u5408\u6cbb\u7597\u7b56\u7565\u4f5c\u7528\u4e0b\u5c0f\u9f20\u72b6\u6001\u56fe\u3002(d) \u5c0f\u9f20\u8033\u90e8\u76ae\u80a4\u7684H&E\u67d3\u8272\u5207\u7247\u53ca\u5176\u6e83\u70c2\u73b0\u8c61\u7684\u5b9a\u91cf\u5206\u6790\u7ed3\u679c (e)\u3002(f) \u5c0f\u9f20\u5c3e\u90e8\u76ae\u80a4\u7684H&E\u67d3\u8272\u5207\u7247\u53ca\u5176\u6e83\u70c2\u73b0\u8c61\u7684\u5b9a\u91cf\u5206\u6790\u7ed3\u679c (g)\u3002<\/span><\/p>\n

\u6b64\u5916\uff0c\u4f53\u5185\u6297\u8f90\u5c04\u6539\u5584\u810f\u5668\u7ec4\u7ec7\u635f\u4f24\u73b0\u8c61\u7684\u5206\u6790\u7ed3\u679c\u8868\u660e\uff0c\u8be5\u5b62\u5b50\u6cb9\u7eb3\u7c73\u7c92\u5b50\u9884\u4fdd\u62a4\u4e0e\u540e\u4fee\u590d\u8054\u5408\u6cbb\u7597\u7b56\u7565\u5bf9\u4e8e\u53d7X \u5c04\u7ebf\u8f90\u7167\u5c0f\u9f20\u7684\u53d7\u635f\u810f\u5668\u5177\u6709\u66f4\u597d\u7684\u4fee\u590d\u6548\u679c\uff1b\u540c\u65f6\u6709\u6548\u7f13\u89e3\u76f8\u5173\u8840\u6db2\u751f\u5316\u6307\u6807\u7684\u5f02\u5e38\u4ee5\u53ca\u8d85\u6c27\u5316\u7269\u6b67\u5316\u9176 (T-SOD), \u4e19\u4e8c\u919b (MDA) \u548c\u8c37\u80f1\u7518\u80bd\u8fc7\u6c27\u5316\u7269\u9176 (GSH-Px) \u7b49\u7684\u542b\u91cf\u5f02\u5e38\u53d8\u5316\uff0c\u4f7f\u5176\u4f53\u5185\u6297\u6c27\u5316\u80fd\u529b\u6062\u590d\u6b63\u5e38\u6c34\u5e73\u3002\u5e76\u4e14\u8be5\u7eb3\u7c73\u4f53\u7cfb\u80fd\u663e\u8457\u9006\u8f6c\u8f90\u7167\u6240\u5bfc\u81f4\u7684\u5c0f\u9f20\u8033\u90e8\u3001\u5c3e\u90e8\u7b49\u76ae\u80a4\u90e8\u4f4d\u51fa\u73b0\u7684\u708e\u6027\u6e83\u70c2\u73b0\u8c61\u3002<\/span><\/p>\n

\u56fe5. \u5b62\u5b50\u6cb9\u7eb3\u7c73\u4f53\u7cfb\u51cf\u8f7bX\u5c04\u7ebf\u8f90\u5c04\u5f15\u8d77\u7684\u591a\u810f\u5668\u635f\u4f24\uff0c\u7ef4\u6301\u673a\u4f53\u5185\u6e90\u6027\u6297\u6c27\u5316\u80fd\u529b\u3002<\/strong><\/span><\/p>\n

\"\"<\/span><\/p>\n

(a) \u5b62\u5b50\u6cb9\u7eb3\u7c73\u4f53\u7cfb\u7684\u63d0\u524d\u4fdd\u62a4\u4e0e\u540e\u4fee\u590d\u8054\u5408\u6cbb\u7597\u7b56\u7565\u5bf9X\u5c04\u7ebf\u8f90\u5c04\u6027\u5c0f\u9f20\u5728\u7ec4\u7ec7\u75c5\u7406\u5b66\u7684\u5f71\u54cd\u3002(b)-(g) \u5c0f\u9f20\u7684\u8840\u6db2\u751f\u5316\u5b66\u6307\u6807\u60c5\u51b5\u3002\u809d\u810f\u5185 (h) \u8d85\u6c27\u5316\u7269\u6b67\u5316\u9176\uff0c(i) \u4e19\u4e8c\u919b\u548c (j) \u8c37\u80f1\u7518\u80bd\u8fc7\u6c27\u5316\u7269\u9176\u7684\u542b\u91cf\u6d4b\u5b9a\u3002<\/span><\/p>\n

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\u57fa\u91d1\u8d44\u52a9<\/b><\/strong><\/span><\/h3>\n

\u4e0a\u8ff0\u7814\u7a76\u5de5\u4f5c\u5f97\u5230\u4e86\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d1 (21877049, 21701051)\u3001\u56fd\u5bb6\u9ad8\u5c42\u6b21\u4eba\u624d\u7279\u6b8a\u652f\u6301\u8ba1\u5212 (W02070191)\u3001\u5e7f\u4e1c\u7701\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u00a0(2017A030313051)\u3001\u4e2d\u56fd\u535a\u58eb\u540e\u79d1\u5b66\u57fa\u91d1 (2016M600705) \u548c\u4e2d\u592e\u9ad8\u6821\u57fa\u672c\u79d1\u7814\u4e1a\u52a1\u8d39\u4e13\u9879\u8d44\u91d1\u00a0(21616106) \u7b49\u9879\u76ee\u7684\u8d44\u52a9\u3002<\/span><\/p>\n

\u8bba\u6587\u4fe1\u606f<\/b><\/strong><\/span><\/h3>\n

Chengli Dai, Lizhen He, Bin Ma and Tianfeng Chen*. Facile Nanolization Strategy for Therapeutic Ganoderma Lucidum Spore Oil to Achieve Enhanced Protection against Radiation-Induced Heart Disease. Small<\/i><\/b><\/em><\/strong>. 2019, 1902642. DOI: 10.1002\/smll.201902642<\/span><\/p>\n

\u672c\u6587\u7531\u66a8\u5357\u5927\u5b66\u9648\u586b\u70fd\u56e2\u961f<\/strong>\u4f9b\u7a3f\u3002<\/span><\/p>\n

\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1: tougao@cailiaoren.com.<\/span><\/p>\n

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