{"id":186134,"date":"2019-10-01T06:30:58","date_gmt":"2019-09-30T22:30:58","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=186134"},"modified":"2019-09-30T22:51:14","modified_gmt":"2019-09-30T14:51:14","slug":"adv-mater-%e6%8a%a5%e9%81%93-%e5%8f%88%e4%b8%80%e9%87%8d%e5%a4%a7%e7%aa%81%e7%a0%b4%ef%bc%81nir-aiegens%e5%8a%a9%e5%8a%9b%e6%b7%b1%e9%83%a8%e8%84%91%e8%a1%80%e7%ae%a1%e5%92%8c%e8%82%bf%e7%98%a4","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=186134","title":{"rendered":"Adv. Mater.\u62a5\u9053: \u53c8\u4e00\u91cd\u5927\u7a81\u7834\uff01NIR AIEgens\u52a9\u529b\u6df1\u90e8\u8111\u8840\u7ba1\u548c\u80bf\u7624\u8840\u7ba1\u9020\u5f71"},"content":{"rendered":"

\u3010\u80cc\u666f\u4ecb\u7ecd\u3011<\/strong><\/p>\n

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\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u65b0\u52a0\u5761\u56fd\u7acb\u5927\u5b66\u7684\u5218\u658c\u6559\u6388\u548c\u5357\u4eac\u5de5\u4e1a\u5927\u5b66\u5218\u6770\u6559\u6388\uff08\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u8054\u5408\u62a5\u9053\u4e86\u4e00\u79cd\u5177\u6709\u957f\u6ce2\u957f\u5438\u6536\u548c\u805a\u96c6\u8bf1\u5bfcNIR\u53d1\u5c04\u7684\u9ad8\u4eae\u5ea6\u8367\u5149\u56e2\uff08BTPETQ\uff09\u7528\u4e8eNIR-II\uff081200 nm\uff09\u6fc0\u53d1\u4e0b\u5bf9\u5c0f\u9f20\u5927\u8111\u548c\u80bf\u7624\u8840\u7ba1\u5b9e\u73b0\u53cc\u5149\u5b50\u8367\u5149\uff082PF\uff09\u6d3b\u4f53\u6210\u50cf\u3002\u901a\u8fc7\u7eb3\u7c73\u6c89\u6dc0\u6cd5\u5236\u5907\u7684BTPETQ\u70b9\u5728\u6c34\u4ecb\u8d28\u4e2d\u5c3a\u5bf8\u5747\u5300\uff0c\u8367\u5149\u91cf\u5b50\u4ea7\u7387\u9ad8\u8fbe19\u00b11%\u3002\u7528BTPETQ\u70b9\u6807\u8bb0\u5c0f\u9f20\u5927\u8111\u8840\u7ba1\u7f51\u7edc\u7ed3\u6784\u76842PF\u6210\u50cf\u5c55\u793a\u4e86\u4e00\u4e2a\u6df1\u5ea6\u4e3a924 \u03bcm\u7684\u4e09\u7ef4\u8840\u7ba1\u7f51\u7edc\u3002\u5728BTPETQ\u70b9\u6807\u8bb0\u7684\u80bf\u7624\u8840\u7ba1\u9020\u5f71\u4e2d\uff0c\u4e0e\u6b63\u5e38\u7ec4\u7ec7\u4e2d\u7684\u8840\u7ba1\u76f8\u6bd4\uff0c\u80bf\u7624\u8840\u7ba1\u663e\u793a\u51fa\u589e\u5f3a\u7684\u53cc\u5149\u5b50\u8367\u5149\uff0c\u8fd9\u53ef\u80fd\u662f\u7531\u4e8e\u80bf\u7624\u8840\u7ba1\u7279\u6b8a\u7684\u6e17\u6f0f\u7ed3\u6784\u548c\u589e\u5f3a\u7684\u5f02\u8d28\u6027\u5bfc\u81f4\u7684\u3002\u8fd9\u79cd\u660e\u663e\u7684\u9020\u5f71\u5dee\u5f02\u6709\u52a9\u4e8e\u8bc6\u522b\u548c\u76d1\u6d4b\u6b63\u5e38\u7ec4\u7ec7\u8840\u7ba1\u4e0e\u80bf\u7624\u7ec4\u7ec7\u4e2d\u7684\u53d8\u5f02\u8840\u7ba1\uff0c\u4e3a\u80bf\u7624\u7684\u68c0\u6d4b\u4ee5\u53ca\u672f\u540e\u5fae\u5c0f\u6b8b\u4f59\u80bf\u7624\u7ec4\u7ec7\u7684\u9ad8\u7075\u654f\u68c0\u6d4b\u63d0\u4f9b\u5e2e\u52a9\u3002\u6b64\u5916\uff0c\u901a\u8fc7\u5bf9\u6bd4\u5206\u6790\u540c\u4e00\u80bf\u7624\u7ec4\u7ec7\u5728NIR-I\u548cNIR-II\u6fc0\u53d1\u4e0b\u7684\u53cc\u5149\u5b50\u8367\u5149\u6210\u50cf\uff0c\u8bc1\u660e\u4e86NIR-II\u6fc0\u53d1\u5149\u5728\u66f4\u6df1\u5c42\u7ec4\u7ec7\u548c\u66f4\u9ad8\u4fe1\u566a\u6bd4\u6210\u50cf\u4e2d\u7684\u5de8\u5927\u4f18\u52bf\u3002\u672c\u7814\u7a76\u5f3a\u8c03\u4e86\u5f00\u53d1NIR-II\u533a\u6fc0\u53d1\u7684\u9ad8\u6548NIR\u8367\u5149\u56e2\u7528\u4e8e\u4f53\u5185\u6df1\u5c42\u7ec4\u7ec7\u548c\u9ad8\u5bf9\u6bd4\u5ea6\u80bf\u7624\u6210\u50cf\u7684\u91cd\u8981\u6027\u3002\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a\u201cNIR-II-Excited Intravital Two-Photon Microscopy Distinguishes Deep Cerebral and Tumor Vasculatures with an Ultrabright NIR-I AIE Luminogen\u201d<\/strong>\u53d1\u8868\u5728\u56fd\u9645\u8457\u540d\u671f\u520aAdv. Mater.<\/strong>\u4e0a\u3002\u7b2c\u4e00\u4f5c\u8005\u4e3a\u65b0\u52a0\u5761\u56fd\u7acb\u5927\u5b66\u738b\u5c11\u4f1f\u535a\u58eb\uff0c\u901a\u8baf\u4f5c\u8005\u4e3a\u65b0\u52a0\u5761\u56fd\u7acb\u5927\u5b66\u5218\u658c\u6559\u6388\u548c\u5357\u4eac\u5de5\u4e1a\u5927\u5b66\u5218\u6770\u6559\u6388\uff0c\u5408\u4f5c\u8005\u5305\u62ec\u65b0\u52a0\u5761\u79d1\u6280\u5c40Chi Ching Goh\u535a\u58eb\u548cLai Guan Ng\u535a\u58eb\u3002<\/strong>
\n \"\"
\n \u3010\u56fe\u6587\u89e3\u8bfb\u3011<\/strong><\/p>\n

\u56fe\u4e00\u3001BTPETQ\u7684\u7ed3\u6784\u548c\u6027\u8d28<\/strong>
\n \"\"\uff08a\uff09BTPETQ\u7684\u5316\u5b66\u7ed3\u6784\u548cBTPETQ\u70b9\u5408\u6210\u7684\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08b\uff09BTPETQ\u5728\u4e0d\u540c\u4f53\u79ef\u5206\u6570\u7684THF\/\u6c34\u4e2d\u7684\u5149\u81f4\u53d1\u5149\uff08PL\uff09\u5149\u8c31\uff1b<\/p>\n

\uff08c\uff09\u5728THF\/\u6c34\u6df7\u5408\u7269\u4e2dBTPETQ\u7684\u5f52\u4e00\u5316PL\u5f3a\u5ea6\uff1b<\/p>\n

\uff08d\uff09BTPETQ\u70b9\u5728\u6c34\u4ecb\u8d28\u4e2d\u7684\u5c3a\u5bf8\u5206\u5e03\uff1b<\/p>\n

\uff08e\uff09BTPETQ\u70b9\u5728\u6c34\u4ecb\u8d28\u4e2d\u7684\u5438\u6536\u548c\u8367\u5149\u5149\u8c31\uff1b<\/p>\n

\uff08f\uff09\u57fa\u4e8e\u5355\u4e2a\u7eb3\u7c73\u70b9\u8ba1\u7b97\u7684BTPETQ\u70b9\u7684\u53cc\u5149\u5b50\u5438\u6536\u622a\u9762\uff08\u03c32<\/sub>\uff09\uff1b<\/p>\n

\uff08g\uff09\u5728\u76f8\u540c\u7684\u98de\u79d2\u6fc0\u5149\u7167\u5c04\u4e0b\uff0cBTPETQ\u70b9\u3001Qtracker 705\u548cAlexa Fluor 647\u7684\u5f52\u4e00\u5316\u53cc\u5149\u5b50\u8367\u5149\u5f3a\u5ea6\u3002<\/p>\n

\u56fe\u4e8c\u3001BTPETQ\u70b9\u6807\u8bb0\u7684\u5c0f\u9f20\u8111\u8840\u7ba1\u7f51\u7edc\u7684\u6d3b\u4f53\u6210\u50cf<\/strong>
\n \"\"\uff08a\uff09\u5728NIR-II\uff081200 nm\uff09\u6fc0\u53d1\u4e0b\uff0c\u4e0d\u540c\u6df1\u5ea6\u533a\u57df\u7684\u8111\u8840\u7ba1\u7f51\u7edc\u76843D\u91cd\u6784\u53cc\u5149\u5b50\u8367\u5149\u56fe\u50cf\uff1b<\/p>\n

\uff08b\uff09\u5728NIR-II\uff081200 nm\uff09\u6fc0\u53d1\u4e0b\uff0c\u4ece0-924 \u03bcm\u6df1\u5ea6\u7684\u8111\u8840\u7ba1\u7f51\u7edc\u76843D\u91cd\u6784\u53cc\u5149\u5b50\u8367\u5149\u56fe\u50cf\uff1b<\/p>\n

\uff08c-d\uff09\u5728NIR-1\uff08920 nm\uff09\uff08c\uff09\u548cNIR-II\uff081200 nm\uff09\uff08d\uff09\u6fc0\u53d1\u4e0b\uff0c\u4e0d\u540c\u6df1\u5ea6\u7684\u76f8\u540c\u8111\u8840\u7ba1\u7684\u53cc\u5149\u5b50\u8367\u5149\u56fe\u50cf\uff1b<\/p>\n

\uff08e\uff09\uff08c\uff09\u548c\uff08d\uff09\u4e2d\u6df1\u5ea6\u4e3a500\u548c788 \u03bcm\u7684\u56fe\u50cf\u7684\u5f52\u4e00\u5316\u7ebf\u5f3a\u5ea6\u5206\u5e03\u3002<\/p>\n

\u56fe\u4e09\u3001BTPETQ\u70b9\u5728\u4f53\u5185\u80bf\u7624\u8840\u7ba1\u4e2d\u6210\u50cf<\/strong>
\n \"\"\uff08a\uff09\u5c0f\u9f20\u8033\u80bf\u7624\u6a21\u578b\u76842PF\u6d3b\u4f53\u6210\u50cf\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08b\uff09\u5177\u6709\u80bf\u7624\u7684\u5c0f\u9f20\u8033\u5782\u76f4\u6a2a\u622a\u9762\u56fe\uff1b<\/p>\n

\uff08c-d\uff09\u6b63\u5e38\u8033\u771f\u76ae\u7684\u4e09\u7ef4\u91cd\u6784SHG\u56fe\u50cf\u548c\u771f\u76ae\u4e2dBTPETQ\u70b9\u6807\u8bb0\u7684\u6b63\u5e38\u8033\u8840\u7ba1\u76842PF\u56fe\u50cf\uff1b<\/p>\n

\uff08e\uff09\u63d2\u56fe\uff08c\uff09\u548c\uff08d\uff09\u7684\u53e0\u52a0\u56fe\u50cf\uff1b<\/p>\n

\uff08f-g\uff09\u80bf\u7624\u771f\u76ae\u7684\u4e09\u7ef4\u91cd\u6784SHG\u56fe\u50cf\uff08f\uff09\u548c\u7531BTPETQ\u70b9\u6807\u8bb0\u7684\u80bf\u7624\u8840\u7ba1\u76842PF\u56fe\u50cf\uff08g\uff09\uff1b<\/p>\n

\uff08h\uff09\u8033\u80bf\u7624\u8fb9\u754c\u5904\u7684\u8840\u7ba1\u76842PF\u56fe\u50cf\uff1b<\/p>\n

\uff08i\uff09\u6ce8\u5c0424 h\u540e\uff0c\u5728\u80bf\u7624\u4e2d\u7d2f\u79ef\u7684BTPETQ\u70b9\u76843D\u91cd\u67842PF\u56fe\u50cf\uff1b<\/p>\n

\uff08j\uff09LuminiCell Tracker 540\u6807\u8bb0\u7684\u80bf\u7624\u8840\u7ba1\u76843D\u91cd\u67842PF\u56fe\u50cf\uff1b<\/p>\n

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\n \"\"\uff08a\uff09NIR-II\u548cNIR-1\u6fc0\u53d1\u4e0b\uff0c\u5728\u4e0d\u540c\u6df1\u5ea6\u6807\u8bb0\u80bf\u7624\u8840\u7ba1\u7684BTPETQ\u70b9\u76842PF\u56fe\u50cf\uff1b<\/p>\n

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\uff08h-i\uff09NIR-1\uff08h\uff09\u548cNIR-II\uff08i\uff09\u6fc0\u53d1\u4e0b\uff0c\u5728\u80bf\u7624\u4e2d\u7d2f\u79ef\u7684BTPETQ\u70b9\u76843D 2PF\u56fe\u50cf\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

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\u6587\u732e\u94fe\u63a5\uff1aNIR-II-Excited Intravital Two-Photon Microscopy Distinguishes Deep Cerebral and Tumor Vasculatures with an Ultrabright NIR-I AIE Luminogen<\/a><\/strong>.\uff08Adv. Mater.<\/em>, 2019<\/strong>, DOI: 10.1002\/adma.201904447\uff09<\/p>\n

\u901a\u8baf\u4f5c\u8005\u7b80\u4ecb<\/strong><\/p>\n

\u5218\u658c\uff0c\u65b0\u52a0\u5761\u56fd\u7acb\u5927\u5b66\u6559\u6388\uff0c\u65b0\u52a0\u5761\u56fd\u7acb\u5927\u5b66\u526f\u6821\u957f\uff08\u4e3b\u7ba1\u79d1\u7814\uff09\uff0c\u5316\u5b66\u4e0e\u751f\u7269\u5206\u5b50\u5de5\u7a0b\u7cfb\u7cfb\u4e3b\u4efb\uff0c\u65b0\u52a0\u5761\u5de5\u7a0b\u9662\u9662\u58eb\uff0c\u4e9a\u592a\u6750\u6599\u79d1\u5b66\u9662\u9662\u58eb\uff0c\u82f1\u56fd\u7687\u5bb6\u5316\u5b66\u4f1a\u4f1a\u58eb<\/strong>\u3002 ACS Materials Letters\u6267\u884c\u4e3b\u7f16, \u540c\u65f6\u62c5\u4efbAdvanced Materials and Advanced Functional Materials \u7b49\u591a\u4e2a\u6742\u5fd7\u7684\u7f16\u59d4\u3002\u81f4\u529b\u4e8e\u5171\u8f6d\u805a\u5408\u7269\u53d1\u5149\u6750\u6599\u3001\u805a\u96c6\u8bf1\u5bfc\u53d1\u5149\u6750\u6599\u7b49\u5728\u751f\u7269\u533b\u5b66\u53ca\u80fd\u6e90\u4e2d\u7684\u5e94\u7528\u7814\u7a76\uff0c\u5176\u6210\u679c\u591a\u6b21\u53d1\u8868\u5728\u56fd\u9645\u4e00\u6d41\u671f\u520a\uff0ch-\u56e0\u5b50\u4e3a 82 \uff08Google Scholar\uff09\uff0c\u8fde\u7eed\u591a\u5e74\u8363\u83b7\u79d1\u777f\u552f\u5b89\u201c\u9ad8\u88ab\u5f15\u79d1\u5b66\u5bb6\u201d\u79f0\u53f7\u3002\u5176\u591a\u9879\u7814\u7a76\u6210\u679c\u5b9e\u73b0\u4ea7\u4e1a\u5316\u5e76\u521b\u7acb\u4e86 LuminiCell \u516c\u53f8\u3002\u4e2a\u4eba\u4e3b\u9875\uff1ahttp:\/\/www.chbe.nus.edu.sg\/faculty\/cheliub\u3002\u8bfe\u9898\u7ec4\u4e3b\u9875\uff1ahttp:\/\/cheed.nus.edu.sg\/stf\/cheliub\/\u3002\u53ef\u5173\u6ce8 Wiley \u5bf9\u5218\u658c\u6559\u6388\u7684\u4eba\u7269\u8bbf\u8c08\uff1a\u4e0e\u5149\u6253\u4ea4\u9053\u7684\u79d1\u5b66\u5bb6\u2014\u2014\u65b0\u52a0\u5761\u56fd\u7acb\u5927\u5b66\u5218\u658c\u6559\u6388\u8bbf\u8c08\uff1a<\/p>\n

http:\/\/www.materialsviewschina.com\/2019\/03\/33902\/<\/p>\n

\u5218\u6770\uff0c\u5357\u4eac\u5de5\u4e1a\u5927\u5b66\u6559\u6388<\/strong>\u30022005\u5e74\u4e8e\u5170\u5dde\u5927\u5b66\u83b7\u5b66\u58eb\u5b66\u4f4d\uff0c2010\u5e74\u4e8e\u534e\u5357\u7406\u5de5\u5927\u5b66\u83b7\u535a\u58eb\u5b66\u4f4d\u3002\u968f\u540e\u8d74\u65b0\u52a0\u5761\u56fd\u7acb\u5927\u5b66\u5218\u658c\u6559\u6388\u8bfe\u9898\u7ec4\u8fdb\u884c\u535a\u58eb\u540e\u7814\u7a76\u5de5\u4f5c\u30022018\u5e744\u6708\u6b63\u5f0f\u52a0\u5165\u5357\u4eac\u5de5\u4e1a\u5927\u5b66\u5148\u8fdb\u6750\u6599\u7814\u7a76\u9662\uff08IAM\uff09\u3002\u5df2\u5728Adv. Mater., Angew. Chem. Int. Ed., ACS Nano, Adv. Funct. Mater., Chem. Sci., Biomaterials, Small, Chem. Commun.\u7b49\u671f\u520a\u53d1\u8868\u8bba\u658750\u4f59\u7bc7\u3002\u76ee\u524d\u4e3b\u8981\u4ece\u4e8b\u8fd1\u7ea2\u5916\u4e8c\u533a\u8367\u5149\u63a2\u9488\u7684\u5f00\u53d1\u53ca\u5176\u5728\u80bf\u7624\u548c\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u4e2d\u7684\u5e94\u7528\u3002<\/p>\n

\u5218\u658c\u56e2\u961f\u8fd1\u671f\u5728\u53cc\u5149\u5b50\u6210\u50cf\u9886\u57df\u7684\u6210\u679c\uff1a<\/strong><\/p>\n

Wang, S.; Hu, F.; Pan, Y.; Ng, L. G.; Liu, B.*, Bright AIEgen\u2013Protein Hybrid Nanocomposite for Deep and High Resolution In Vivo Two-Photon Brain Imaging. Adv. Funct. Mater.<\/em> 2019<\/strong>, 29<\/em>, 1902717.<\/p>\n

Wang, S.#; Wu, W.#; Manghnani, P.; Xu, S.; Wang, Y.; Goh, C. C.; Ng, L. G.; Liu, B.*, Polymerization Enhanced Two-Photon Photosensitization for Precise Photodynamic Therapy. ACS nano<\/em> 2019<\/strong>, 13<\/em>, 3095\u20133105.<\/p>\n

Wang, S.; Liu, J.; Feng, G.; Ng, L. G.; Liu, B.*, NIR\u2010II Excitable Conjugated Polymer Dots with Bright NIRI Emission for Deep In Vivo Two-Photon Brain Imaging Through Intact Skull. Adv. Funct. Mater.<\/em> 2019<\/strong>, 29<\/em>, 1808365. (Cover Feature)<\/p>\n

Zhen, S.#; Wang, S.#; Li, S.; Luo, W.; Gao, M.; Ng, L. G.; Goh, C. C.; Qin, A.; Zhao, Z.*; Liu, B.*; Tang, B. Z.*, Efficient Red\/Near-Infrared Fluorophores Based on Benzo [1,2-b:4,5-b’] dithiophene 1,1,5,5-Tetraoxide for Targeted Photodynamic Therapy and In Vivo Two-Photon Fluorescence Bioimaging. Adv. Funct. Mater.<\/em> 2018<\/strong>, 28<\/em>, 1706945. (Cover Feature)<\/p>\n

\u672c\u6587\u7531CQR\u7f16\u8bd1\u3002<\/p>\n

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