{"id":186723,"date":"2019-10-05T06:30:17","date_gmt":"2019-10-04T22:30:17","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=186723"},"modified":"2019-10-04T17:40:27","modified_gmt":"2019-10-04T09:40:27","slug":"%e5%b7%b2%e6%a0%a1%e7%a8%bf%e4%bb%b6-%e5%94%90%e6%9c%ac%e5%bf%a0%e9%99%a2%e5%a3%ab%e7%ad%89%e4%ba%ba-acs-nano-%e5%88%86%e5%ad%90%e5%8a%9f%e8%83%bd%e5%8c%96%e8%ae%be%e8%ae%a1%e8%b0%83%e8%8a%82","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=186723","title":{"rendered":"\u5510\u672c\u5fe0\u9662\u58eb\u7b49\u4eba ACS Nano: \u5206\u5b50\u529f\u80fd\u5316\u8bbe\u8ba1\u8c03\u8282\u7ec6\u80de\u5668\u7279\u5f02\u6027\u548c\u5149\u52a8\u529b\u6cbb\u7597\u6548\u7387"},"content":{"rendered":"

\u3010\u80cc\u666f\u4ecb\u7ecd\u3011<\/strong><\/p>\n

\u76ee\u524d\uff0c\u5728\u4e34\u5e8a\u5e94\u7528\u4e2d\uff0c\u5149\u52a8\u529b\u6cbb\u7597\uff08PDT\uff09\u5728\u6cbb\u7597\u5404\u79cd\u5b9e\u4f53\u7624\u4e2d\u88ab\u5e7f\u6cdb\u5173\u6ce8\u3002PDT\u5177\u6709\u65f6\u7a7a\u7cbe\u5ea6\u9ad8\u3001\u65e0\u521b\u4f24\u6027\u3001\u53ef\u63a7\u6027\u3001\u4f4e\u6bd2\u6027\u4ee5\u53ca\u53ef\u91cd\u590d\u6cbb\u7597\u7b49\u4f18\u70b9\uff0c\u5176\u673a\u7406\u4e0e\u5149\u654f\u5242\uff08PSs\uff09\u5728\u5149\u7167\u5c04\u4e0b\u4ea7\u751f\u6d3b\u6027\u6c27\uff08ROS\uff09\u6709\u5173\u3002ROS\u4e3b\u8981\u5305\u62ec\uff1aI\u578b\u7684\u8d85\u6c27\u9634\u79bb\u5b50\uff08O2<\/sub>\u2022-<\/sup>\uff09\u3001\u7f9f\u57fa\u81ea\u7531\u57fa\uff08\u2022OH\uff09\uff0c\u8fc7\u6c27\u5316\u7269\uff08O2<\/sub>2-<\/sup>\uff09\uff1bII\u578b\u7684\u5355\u7ebf\u6001\u6c27\uff081<\/sup>O2<\/sub>\uff09\u3002\u4f46\u662f\uff0c\u5982\u4f55\u83b7\u5f97\u4e00\u4e2a\u9ad8\u6548\u548c\u7406\u60f3\u7684PSs\u4ecd\u7f3a\u4e4f\u901a\u7528\u7684\u6307\u5bfc\u539f\u5219\u3002\u4f17\u6240\u5468\u77e5\uff0c\u535f\u5549\u548c\u915e\u83c1\u7c7b\u5206\u5b50\u662f\u7814\u7a76\u6700\u5e7f\u6cdb\u7684PSs\uff0c\u5e76\u4e14\u5df2\u5728\u4e34\u5e8a\u4e2d\u5e94\u7528\u3002\u7136\u800c\uff0c\u7531\u4e8e\u8fd9\u7c7bPSs\u5177\u6709\u5927\u7684\u5171\u8f6d\u4f53\u7cfb\u6613\u5728\u6c34\u6eb6\u6db2\u4e2d\u805a\u96c6\uff0c\u5b58\u5728\u805a\u96c6\u5bfc\u81f4\u8367\u5149\u731d\u706d\uff08ACQ\uff09\u6548\u5e94\uff0c\u4f1a\u964d\u4f4e\u8367\u5149\u5f3a\u5ea6\u548cPDT\u6548\u7387\uff0c\u4ece\u800c\u96be\u4ee5\u5b9e\u73b0\u6210\u50cf\u6307\u5bfc\u7684PDT\u3002\u56e0\u6b64\uff0c\u5177\u6709\u805a\u96c6\u8bf1\u5bfc\u53d1\u5149\uff08AIE\uff09\u7279\u6027\u7684PSs\u6709\u671b\u89e3\u51b3\u4e0a\u8ff0\u95ee\u9898\u3002AIE PSs\u5728\u805a\u96c6\u4f53\u6216\u7eb3\u7c73\u9897\u7c92\u4e2d\u4e0d\u4ec5\u80fd\u591f\u589e\u5f3a\u8367\u5149\u5f3a\u5ea6\uff0c\u800c\u4e14\u53ef\u6709\u6548\u5730\u4ea7\u751fROS\u3002\u4f46\u662f\uff0c\u5bf9\u4e8eAIE PSs\u7684\u7ed3\u6784\u6027\u80fd\u5173\u7cfb\u53ca\u4ea7\u751fROS\u7684\u673a\u5236\u7814\u7a76\u5374\u76f8\u5bf9\u8f83\u5c11\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u9999\u6e2f\u79d1\u6280\u5927\u5b66\u7684\u5510\u672c\u5fe0\u9662\u58eb\u548c\u5357\u65b9\u533b\u79d1\u5927\u5b66\u7684\u90d1\u78ca\u6559\u6388\uff08\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u8054\u5408\u62a5\u9053\u4e86\u4ed6\u4eec\u4ee5\u4e09\u82ef\u80fa-\u6c2e\u6742\u82b4\u916e\u4e3a\u6838\u5fc3\u8bbe\u8ba1\u5e76\u5408\u6210\u4e86\u4e00\u7cfb\u5217PSs\u3002\u540c\u65f6\uff0c\u5bf9\u5b83\u4eec\u7684\u7ed3\u6784\u6027\u8d28-\u5e94\u7528\u5173\u7cfb\u8fdb\u884c\u4e86\u7cfb\u7edf\u7684\u7814\u7a76\uff0c\u53d1\u73b0\u9633\u79bb\u5b50\u5316\u5206\u5b50\u662f\u901a\u8fc7\u9776\u5411\u7ebf\u7c92\u4f53\u6765\u63d0\u9ad8AIE PSs\u7684PDT\u6548\u7387\u7684\u6709\u6548\u7b56\u7565\u3002\u4ece\u5206\u5b50\u5355\u5206\u6563\u72b6\u6001\u5230\u805a\u96c6\u72b6\u6001\uff0c\u7531\u4e8e\u5206\u5b50\u5185\u8fd0\u52a8\u7684\u9650\u5236\u548c\u7cfb\u95f4\u7a7f\u8d8a\u7684\u589e\u5f3a\uff0c\u5177\u6709\u805a\u96c6\u8bf1\u5bfc\u53d1\u5149\uff08AIE\uff09\u7684PSs\u540c\u65f6\u589e\u5f3a\u4e86\u8367\u5149\u5f3a\u5ea6\u548c\u6d3b\u6027\u6c27\u4ea7\u751f\u901f\u7387\u3002\u6b64\u5916\uff0c\u9633\u79bb\u5b50\u5316\u7684\u7ebf\u7c92\u4f53\u9776\u5411PSs\u7684PDT\u6548\u7387\u9ad8\u4e8e\u975e\u79bb\u5b50\u5316\u7684\u8102\u6ef4\u9776\u5411\u7684PSs\u3002\u901a\u8fc7\u5c06PDT\u4e0e\u653e\u5c04\u7597\u6cd5\u76f8\u7ed3\u5408\uff0c\u53ef\u4ee5\u8fdb\u4e00\u6b65\u589e\u5f3aAIE PSs\u6740\u6b7b\u764c\u7ec6\u80de\u7684\u80fd\u529b\u3002\u603b\u4e4b\uff0c\u8be5\u7814\u7a76\u7ed3\u679c\u6709\u5229\u4e8e\u6307\u5bfc\u4eba\u4eec\u8bbe\u8ba1\u5408\u6210\u5177\u6709\u66f4\u9ad8PDT\u6548\u7387\u548c\u6027\u80fd\u7684AIE PSs\u5206\u5b50\u3002\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a\u201cTuning Organelle Specificity and Photodynamic Therapy Efficiency by Molecular Function Design\u201d<\/strong>\u53d1\u8868\u5728\u56fd\u9645\u8457\u540d\u671f\u520aACS Nano<\/strong>\u4e0a\u3002<\/p>\n

\u672c\u6587\u5171\u540c\u4e00\u4f5c\u4e3a\u9999\u6e2f\u79d1\u6280\u5927\u5b66\u7684\u5218\u5fd7\u6d0b\u535a\u58eb\u548c\u5357\u65b9\u533b\u79d1\u5927\u5b66\u7684\u90b9\u822a\u535a\u58eb\u3002<\/strong><\/p>\n

\"\"<\/p>\n

\u3010\u56fe\u6587\u89e3\u8bfb\u3011<\/strong><\/p>\n

\u56fe\u4e00\u3001\u76ee\u6807\u5206\u5b50\u7684\u5206\u5b50\u7ed3\u6784\u3001\u6469\u5c14\u5438\u6536\u7cfb\u6570\u548cPL\u5149\u8c31<\/strong><\/p>\n

\"\"\uff08A\uff09\u76ee\u6807\u6750\u6599\u7684\u5206\u5b50\u7ed3\u6784\uff1b<\/p>\n

\uff08B\uff09THF\u6eb6\u6db2\u4e2dTPAN\u3001TPAPy\u3001TPANPF6<\/sub>\u548cTPAPyPF6<\/sub>\u7684\u6469\u5c14\u5438\u6536\u7cfb\u6570\uff1b<\/p>\n

\uff08C\uff09\u5728\u4e8c\u6c27\u516d\u73af\u6eb6\u6db2\u4e2d\u7684TPAN\u3001TPAPy\u3001TPANPF6<\/sub>\u548cTPAPyPF6<\/sub>\u7684\u5f52\u4e00\u5316PL\u5149\u8c31\u3002<\/p>\n

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\n \"\"\uff08A\uff09\u56fa\u6001\u7684TPAPy\u3001TPANPF6<\/sub>\u548cTPAPyPF6<\/sub>\u7684\u5f52\u4e00\u5316PL\u5149\u8c31\uff1b<\/p>\n

\uff08B\uff09\u5728THF\/\u6c34\uff08TPAPy\uff09\u6216DMSO\/\u6c34\uff08TPANPF6<\/sub>\u548cTPAPyPF6<\/sub>\uff09\u6eb6\u6db2\u4e2d\u76f8\u5bf9PL\u5f3a\u5ea6\uff08I\/I0<\/sub>\uff09\u7684\u5173\u7cfb\u56fe\uff1b<\/p>\n

\uff08C\uff09\u5728PBS\u4e2d\u6709\u65e0\u56db\u79cd\u5316\u5408\u7269\u4ee5\u53ca\u4e0d\u540c\u65f6\u95f4\u7684\u5149\u7167\u5c04\u4e0b\uff0cH2DCF-DA\u5728525 nm\u5904\u7684PL\u5f3a\u5ea6\u7684\u53d8\u5316\uff1b<\/p>\n

\uff08D\uff09\u6709\u65e0\u56db\u79cd\u5316\u5408\u7269\u548c\u5149\u7167\u5c04\u4e0b\u7684ABDA\u7684\u5206\u89e3\u901f\u7387\u3002<\/p>\n

\u56fe\u4e09\u3001TPANPF6<\/sub>\u7684ROS\u8868\u5f81\u3001PL\u8870\u51cf\u66f2\u7ebf\u3001\u6cbb\u7597\u673a\u7406\u548c\u793a\u610f\u56fe<\/strong>
\n \"\"\uff08A\uff09\u5b58\u5728TPANPF6<\/sub>\u7684\u60c5\u51b5\u4e0b\uff0c\u5728\u5177\u6709\u4e0d\u540c\u6c34\u542b\u91cf\uff08f<\/em>w<\/sub>\uff09\u7684DMSO\/\u6c34\u6df7\u5408\u6eb6\u6db2\u4e2d\uff0c\u5728\u5149\u7167\u5c04\u4e0bABDA\u7684 \u5206\u89e3\u901f\u7387\uff1b<\/p>\n

\uff08B\uff09TPANPF6<\/sub>\u5728\u4e0d\u540c\u6761\u4ef6\u4e0b\u7684PL\u8870\u51cf\u66f2\u7ebf\uff1b<\/p>\n

\uff08C\uff09\u5149\u52a8\u529b\u6cbb\u7597\u7684\u57fa\u672c\u673a\u7406\u793a\u610f\u56fe\uff1b<\/p>\n

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\u56fe\u56db\u3001\u5408\u6210\u5206\u5b50\u5bf9HeLa\u7ec6\u80de\u67d3\u8272\u5171\u5b9a\u4f4d\u6210\u50cf<\/strong>
\n \"\"\uff08A1-A4\uff09\u5206\u522b\u7528TPAN\u3001TPAPy\u3001TPANPF6<\/sub>\u3001TPAPyPF6<\/sub>\u5bf9HeLa\u7ec6\u80de\u5171\u805a\u7126\u6210\u50cf\uff1b<\/p>\n

(B1\u548cB2) Nile Red \uff08\u8102\u6ef4\uff09\uff0c(B3\u548cB4) MitoTracker Deep Red \uff08\u7ebf\u7c92\u4f53\uff09\u5bf9HeLa\u7ec6\u80de\u5171\u805a\u7126\u6210\u50cf\uff1b<\/p>\n

\uff08C1-C4\uff09\u76f8\u5e94\u7684A\u548cB\u56fe\u7684\u5408\u5e76\u56fe\u50cf\uff1b<\/p>\n

\uff08D1-D4\uff09\u6563\u70b9\u56fe\uff0c\u6307\u793aA\u548cB\u4e4b\u95f4\u7684\u6821\u6b63\u7cfb\u6570\u3002<\/p>\n

\u56fe\u4e94\u3001\u4e0d\u540c\u6d53\u5ea6\u76ee\u6807\u5206\u5b50\u7684PDT\u6548\u7387<\/strong>
\n \"\"\uff08A\uff09\u5728\u6697\u6216\u767d\u5149\u7167\u5c04\u4e0b\uff0c\u4e0d\u540c\u6d53\u5ea6TPAN\u67d3\u8272HeLa\u7ec6\u80de\u7684\u7ec6\u80de\u5b58\u6d3b\u7387\uff1b<\/p>\n

\uff08B\uff09\u5728\u6697\u6216\u767d\u5149\u7167\u5c04\u4e0b\uff0c\u4e0d\u540c\u6d53\u5ea6TPAPy\u67d3\u8272HeLa\u7ec6\u80de\u7684\u7ec6\u80de\u5b58\u6d3b\u7387\uff1b<\/p>\n

\uff08C\uff09\u5728\u6697\u6216\u767d\u5149\u7167\u5c04\u4e0b\uff0c\u4e0d\u540c\u6d53\u5ea6TPANPF6<\/sub>\u67d3\u8272HeLa\u7ec6\u80de\u7684\u7ec6\u80de\u5b58\u6d3b\u7387\uff1b<\/p>\n

\uff08D\uff09\u5728\u6697\u6216\u767d\u5149\u7167\u5c04\u4e0b\uff0c\u4e0d\u540c\u6d53\u5ea6TPAPyPF6<\/sub>\u67d3\u8272HeLa\u7ec6\u80de\u7684\u7ec6\u80de\u5b58\u6d3b\u7387\u3002<\/p>\n

\u56fe\u516d\u3001\u653e\u7597\u548cPDT\u8054\u5408\u7597\u6cd5\u7684\u5b9e\u9a8c\u8bc4\u4ef7<\/strong>
\n \"\"\uff08A\uff09\u7528\u5404\u79cd\u5904\u7406\u7684HeLa\u7ec6\u80de\u7684\u5b58\u6d3b\u66f2\u7ebf\uff1b<\/p>\n

\uff08B\uff09\u4e0d\u540c\u5904\u7406\u6761\u4ef6\u4e0b\u5177\u6709\u4ee3\u8868\u6027\u7684\u7ec6\u80de\u96c6\u843d\u5f62\u6210\u56fe\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

\u7efc\u4e0a\u6240\u8ff0\uff0c\u4f5c\u8005\u5408\u6210\u4e86\u56db\u79cd\u4ee5\u4e09\u82ef\u80fa-\u6c2e\u6742\u82b4\u916e\u4e3a\u6838\u7684PSs\uff0c\u53d1\u73b0\u5b83\u4eec\u4ec5\u6709\u7ec6\u5fae\u7684\u5b98\u80fd\u56e2\u5dee\u522b\uff0c\u5374\u8868\u73b0\u51fa\u4e0d\u540c\u7684\u5149\u7269\u7406\u6027\u8d28\u548c\u751f\u7269\u5e94\u7528\u3002\u7814\u7a76\u53d1\u73b0\u9633\u79bb\u5b50\u5316\u5206\u5b50\u662f\u63d0\u9ad8PSs\u7684PDT\u6548\u7387\u7684\u6709\u6548\u7b56\u7565\u3002\u7531\u4e8e\u5206\u5b50\u7684\u805a\u96c6\u8bf1\u5bfc\u53d1\u5149\u673a\u7406\uff0cAIE PSs\u8868\u73b0\u51fa\u4ece\u5206\u5b50\u5206\u6563\u6001\u5230\u805a\u96c6\u6001\u540c\u65f6\u589e\u52a0\u8367\u5149\u5f3a\u5ea6\u548cROS\u751f\u6210\u901f\u7387\u7684\u73b0\u8c61\u3002\u8fd9\u6709\u52a9\u4e8e\u8f7b\u677e\u5b9e\u73b0\u6210\u50cf\u6307\u5bfc\u7684PDT\uff0c\u800c\u4e0d\u9700\u8981\u590d\u6742\u7684\u5316\u5b66\u5408\u6210\u3002\u6b64\u5916\uff0cAIE PSs\u4e5f\u53ef\u4f5c\u4e3a\u653e\u5c04\u6cbb\u7597\u7684\u589e\u654f\u5242\uff0cPDT\u8054\u5408\u653e\u5c04\u6cbb\u7597\u6781\u5927\u5730\u63d0\u9ad8\u4e86\u5bf9\u764c\u7ec6\u80de\u7684\u6740\u4f24\u6548\u7387\u3002\u603b\u4e4b\uff0c\u8be5\u7814\u7a76\u4e3aPSs\u7684\u5206\u5b50\u8bbe\u8ba1\u63d0\u4f9b\u4e86\u4e00\u79cd\u65b0\u601d\u8def\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aTuning Organelle Specificity and Photodynamic Therapy Efficiency by Molecular Function Design<\/a><\/strong>. (ACS Nano<\/em>, 2019<\/strong>, DOI: 10.1021\/acsnano.9b04430)<\/p>\n

\u901a\u8baf\u4f5c\u8005\u7b80\u4ecb<\/strong><\/p>\n

\"\"<\/p>\n

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\"\"<\/p>\n

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