{"id":187029,"date":"2019-10-17T06:30:31","date_gmt":"2019-10-16T22:30:31","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=187029"},"modified":"2019-10-16T16:12:17","modified_gmt":"2019-10-16T08:12:17","slug":"%e3%80%90%e9%a6%96%e6%8e%a8%e3%80%91%e6%a2%b3%e7%90%86%ef%bc%9a%e4%bb%8enature%e7%9c%8b%e6%b0%b4%e5%87%9d%e8%83%b6%e6%9d%90%e6%96%99%e7%9a%84%e6%9c%80%e6%96%b0%e6%88%90%e6%9e%9c","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=187029","title":{"rendered":"\u68b3\u7406\uff1a\u4eceNature\u770b\u6c34\u51dd\u80f6\u6750\u6599\u7684\u6700\u65b0\u6210\u679c"},"content":{"rendered":"

\u5f15\u8a00<\/h3>\n

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\u56fe1<\/p>\n

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a) \u81ea\u6108\u6027\u542b\u94f6\u786b\u9187\u914d\u4f4d\u6c34\u51dd\u80f6\u5408\u6210\u793a\u610f\u56fe\uff1bb) \u6ce8\u5165\u8840\u7ba1\u751f\u6210\u836f\u7269\u83b7\u5f97\u53ef\u81ea\u6211\u4fee\u590d\uff0c\u53ef\u6ce8\u5c04\uff0c\u6297\u83cc\uff0c\u591a\u529f\u80fd\u6c34\u51dd\u80f6\uff1bc) I\u578b\u7cd6\u5c3f\u75c5\u8db3\u6e83\u75a1\uff08\u5de6\uff09\u548c\u6c34\u51dd\u80f6\u6cbb\u7597\u540e\u6548\u679c\uff08\u53f3\uff09;\u00a0d) \u6c34\u51dd\u80f6\u4fee\u590d\u4f5c\u7528\u673a\u5236\u793a\u610f\u56fe\u3002[1]<\/sup><\/p>\n

2. \u5177\u6709\u5f3a\u7c98\u6027\u7684\u6b62\u8840\u6c34\u51dd\u80f6<\/h3>\n

\u4e0d\u53ef\u63a7\u51fa\u8840\u662f\u91cd\u5927\u521b\u4f24\u548c\u5916\u79d1\u624b\u672f\u8fc7\u7a0b\u4e2d\u7ecf\u5e38\u9047\u5230\u7684\u95ee\u9898\u3002\u4e0d\u53ef\u63a7\u51fa\u8840\u662f\u76ee\u524d\u5168\u7403\u6b7b\u4ea1\u7387\u9ad8\u7684\u4e00\u4e2a\u4e3b\u8981\u539f\u56e0\u3002\u5176\u4e2d\uff0c\u4fee\u590d\u4e3b\u52a8\u8109\u7834\u88c2\u548c\u5fc3\u810f\u7a7f\u900f\u4f24\u53e3\u5f15\u8d77\u7684\u5fc3\u810f\u51fa\u8840\u662f\u5916\u79d1\u624b\u672f\u7684\u96be\u70b9\u3002\u76ee\u524d\u5e38\u7528\u7684\u6b62\u8840\u5242\u5bf9\u4e8e\u6e7f\u73af\u5883\u548c\u8fd0\u52a8\u7ec4\u7ec7\u7684\u7c98\u9644\u529b\u8f83\u5f31\uff0c\u5f88\u96be\u63a7\u5236\u521b\u4f24\u6027\u52a8\u8109\u548c\u5fc3\u810f\u4f24\u53e3\u7684\u51fa\u8840\u3002\u5916\u79d1\u624b\u672f\u7f1d\u5408\u662f\u5f53\u524d\u552f\u4e00\u7528\u4e8e\u4e3b\u52a8\u8109\u7834\u88c2\u548c\u5fc3\u810f\u4f24\u53e3\u5bc6\u5c01\u7684\u4e34\u5e8a\u65b9\u6cd5\u3002\u7136\u800c\uff0c\u8fd9\u5728\u5927\u591a\u6570\u533b\u9662\u73af\u5883\u5916\u548c\u7d27\u6025\u60c5\u51b5\u4e0b\u90fd\u4e0d\u53ef\u884c\u3002\u968f\u7740\u6750\u6599\u79d1\u6280\u7684\u53d1\u5c55\uff0c\u79d1\u5b66\u5bb6\u4eec\u7814\u7a76\u51fa\u4e86\u8bb8\u591a\u5feb\u901f\u4f24\u53e3\u5bc6\u5c01\u6750\u6599\uff0c\u5982\u7ea4\u7ef4\u86cb\u767d\u80f6\uff0c\u660e\u80f6\uff0c\u6c27\u5316\u7ea4\u7ef4\u7d20\uff0c\u80bd\u7b49\u3002\u7136\u800c\uff0c\u7531\u4e8e\u8fd9\u4e9b\u6750\u6599\u5728\u6e7f\u7ec4\u7ec7\u8868\u9762\u7c98\u9644\u6027\u5dee\uff0c\u7c98\u7ed3\u673a\u5236\u8f83\u5f31\uff0c\u8fd9\u4e9b\u6750\u6599\u5e76\u4e0d\u9002\u7528\u4e8e\u4e3b\u52a8\u8109\u548c\u5fc3\u810f\u5916\u4f24\u6b62\u8840\u3002\u7528\u4e8e\u52a8\u8109\u53ca\u5fc3\u810f\u7ec4\u7ec7\u5904\u7684\u5feb\u901f\u5bc6\u5c01\u6027\u6750\u6599\u9700\u8981\u5728\u8fde\u7eed\u6d41\u52a8\u7684\u60c5\u51b5\u4e0b\u5feb\u901f\u7c98\u5408\uff0c\u5728\u6e7f\u7ec4\u7ec7\u58c1\u548c\u8868\u9762\u4e4b\u95f4\u5177\u6709\u5f3a\u7c98\u5408\u529b\uff0c\u62e5\u6709\u53ef\u4ee5\u627f\u53d7\u8840\u538b\u7684\u9ad8\u673a\u68b0\u5f3a\u5ea6\u4ee5\u53ca\u751f\u7269\u76f8\u5bb9\u6027\u3002\u6700\u8fd1\uff0c\u6d59\u6c5f\u5927\u5b66\u533b\u5b66\u9662\u4e8c\u9644\u9662\u6b27\u9633\u5b8f\u4f1f\u6559\u6388\u548c\u4ed6\u7684\u56e2\u961f\u8bbe\u8ba1\u4e86\u4e00\u79cd\u4eff\u751f\u7ec4\u7ec7\u6c34\u51dd\u80f6\u7c98\u5408\u5242\u6750\u6599\u3002\u8fd9\u79cd\u6750\u6599\u53ef\u4ee5\u5728\u51e0\u79d2\u5185\u805a\u5408\u5e76\u7c98\u9644\u3002\u5728\u7d2b\u5916\u7ebf\u5149\u6fc0\u6d3b\u540e\u7262\u56fa\u5730\u7c98\u5408\u5230\u6e7f\u751f\u7269\u7ec4\u7ec7\u8868\u9762\u3002\u8be5\u6750\u6599\u7684\u8bbe\u8ba1\u53d7\u5230\u751f\u7269\u7ed3\u7f14\u7ec4\u7ec7\u7684\u7ec6\u80de\u5916\u57fa\u8d28\u7684\u542f\u53d1\u3002\u5b9e\u9a8c\u5c0f\u7ec4\u8bbe\u8ba1\u7684\u6c34\u51dd\u80f6\u751f\u7269\u7c98\u5408\u5242\u75315%\u7684\u7532\u57fa\u4e19\u70ef\u9178\u660e\u80f6(GelMA)\uff0c1.25%\u7684N-(2aminoethyl)\u22124-(4-(hydroxymethyl)\u22122-methoxy-5-nitrosophenoxy) butanamide (NB)\u8fde\u63a5\u7cd6\u80fa\u805a\u7cd6\u900f\u660e\u8d28\u9178\uff08HA-NB\uff09\u548c0.1%\u7684\u805a\u5408\u5f15\u53d1\u5242\u82ef\u57fa-2,4,6-\u4e09\u7532\u57fa\u82ef\u7532\u9170\u57fa\u6b21\u81a6\u9178\u9502\uff08LAP\uff09\u3002\u5c06\u7532\u57fa\u4e19\u70ef\u9178\u660e\u80f6(GelMA)\u5f15\u5165\u6c34\u51dd\u80f6\u53ef\u4fdd\u6301\u5176\u6e7f\u4f24\u53e3\u5bc6\u5c01\u7684\u80fd\u529b\uff0c\u5e76\u5927\u5e45\u5ea6\u52a0\u901f\u805a\u5408\uff0c\u907f\u514d\u4e86\u672a\u805a\u5408\u7684\u6750\u6599\u5728\u5f62\u6210\u952e\u5408\u51dd\u80f6\u4e4b\u524d\u88ab\u8840\u6d41\u51b2\u8d70\uff0c\u4ece\u800c\u5927\u5927\u63d0\u9ad8\u4e86\u8fd9\u79cd\u4f24\u53e3\u5bc6\u5c01\u6c34\u51dd\u80f6\u7684\u4e34\u5e8a\u5b9e\u7528\u6027\u3002\u5b9e\u9a8c\u7ed3\u679c\u663e\u793a\uff0c\u7531\u8be5\u6750\u6599\u4fee\u590d\u7684\u8840\u7ba1\u53ef\u4ee5\u627f\u53d7\u9ad8\u8fbe290 mmHg\u7684\u8840\u538b\uff0c\u9ad8\u4e8e\u5927\u591a\u6570\u4e34\u5e8a\u60c5\u51b5\u4e0b\u7684\u8840\u538b\uff08\u6536\u7f29\u538bBP 60-160 mmHg\uff09\u3002\u9664\u6b64\u4e4b\u5916\uff0c\u52a8\u7269\u5b9e\u9a8c\u663e\u793a\uff0c\u8be5\u6c34\u51dd\u80f6\u53ef\u4ee520s\u5185\u963b\u6b624~5 mm\u957f\u5207\u53e3\u4f24\u53e3\u7684\u732a\u9888\u52a8\u8109\u548c\u76f4\u5f84\u4e3a6 mm\u7684\u5fc3\u810f\u7a7f\u900f\u5b54\u7684\u732a\u5fc3\u810f\u9ad8\u538b\u51fa\u8840\u4e14\u4e0d\u4f7f\u7528\u7f1d\u5408\u7ebf\u3002\u7528\u8be5\u6c34\u51dd\u80f6\u8fdb\u884c\u6b62\u8840\u6cbb\u7597\u540e\u7684\u732a\u6210\u529f\u5b58\u6d3b\u4e86\u4e0b\u6765\u3002\u8fd9\u79cd\u4e0d\u9700\u8981\u7f1d\u5408\u5373\u53ef\u5b9e\u73b0\u5feb\u901f\u6b62\u8840\u548c\u5bc6\u5c01\u7684\u6750\u6599\uff0c\u6709\u671b\u88ab\u8fd0\u7528\u4e8e\u5916\u79d1\u624b\u672f\u548c\u7d27\u6025\u6b62\u8840\u3002<\/p>\n

\u56fe2\u00a0\u6750\u6599\u6210\u5206\u548c\u7ed3\u6784\u793a\u610f\u56fe\u53ca\u5149\u8bf1\u5bfc\u5408\u6210\u6750\u6599\u6d41\u7a0b\u793a\u610f\u56fe\u3002\u00a0[2]<\/sup><\/p>\n

\"\"<\/p>\n

3. \u5177\u6709\u5404\u5411\u5f02\u6027\u54cd\u5e94\u9a71\u52a8\u80fd\u529b\u7684\u81ea\u4fee\u590d\u6c34\u51dd\u80f6<\/h3>\n

\u8bb8\u591a\u6d3b\u4f53\u751f\u7269\u4f53\u5185\uff0c\u5927\u591a\u6570\u7ec4\u7ec7\u5177\u6709\u4ece\u5206\u5b50\u6c34\u5e73\u5230\u5b8f\u89c2\u6c34\u5e73\u7684\u5404\u5411\u5f02\u6027\u5f62\u6001\uff0c\u7ed3\u6784\u548c\u53cd\u5e94\u3002\u4f8b\u5982\uff0c\u7d27\u5bc6\u5e73\u884c\u6392\u5e03\u7ed3\u6784\u7684\u80f6\u539f\u7ea4\u7ef4\u4f7f\u808c\u8089\u5177\u6709\u663e\u8457\u7684\u4e00\u7ef4\u65b9\u5411\u4e0a\u7684\u6536\u7f29\u529b\u3002\u7531\u4e8e\u5177\u6709\u826f\u597d\u7684\u751f\u7269\u76f8\u5bb9\u6027\u548c\u751f\u7269\u7cfb\u7edf\u7684\u76f8\u4f3c\u6027\uff0c\u6c34\u51dd\u80f6\u88ab\u5e7f\u6cdb\u7528\u4f5c\u4eba\u9020\u5668\u5b98\u6216\u8005\u7ec4\u7ec7\u5de5\u7a0b\u7684\u805a\u5408\u7269\u652f\u67b6\u3002\u7136\u800c\uff0c\u5927\u591a\u6570\u6c34\u51dd\u80f6\u901a\u5e38\u8868\u73b0\u51fa\u5404\u5411\u540c\u6027\u7ed3\u6784\uff0c\u4ece\u800c\u5bfc\u81f4\u5728\u63a5\u53d7\u5916\u754c\u523a\u6fc0\u65f6\u53d1\u751f\u975e\u5b9a\u5411\u5f62\u53d8\u3002\u53d7\u5230\u667a\u80fd\u751f\u7269\u7ec4\u7ec7\u7684\u542f\u53d1\uff0c\u4e2d\u56fd\u79d1\u6280\u5927\u5b66\u4ece\u6000\u840d\u6559\u6388\u548c\u5979\u7684\u56e2\u961f\u8bbe\u8ba1\u4e86\u4e00\u79cd\u7531\u9ad8\u5ea6\u6709\u5e8f\u7684\u5c42\u72b6\u7f51\u7edc\u7ed3\u6784\u7ec4\u6210\u7684\uff0c\u4ee5\u91d1\u5c5e\u94a0\u7c73\u7ed3\u6784\u4e3a\u88c5\u914d\u7ed3\u6784\u7684\u5404\u5411\u5f02\u6027\u6c34\u51dd\u80f6\u6750\u6599\uff08\u6750\u6599\u7ed3\u6784\u53ef\u89c1\u4e8e\u56fe3\uff09\u3002\u5b9e\u9a8c\u56e2\u961f\u63d0\u51fa\u4f7f\u7528\u91d1\u7eb3\u7c73\u9897\u7c92\u7684\u52a8\u6001\u786b\u9187\u76d0\uff08RS-Au\uff09\u914d\u4f4d\u4f5c\u4e3a\u6c34\u51dd\u80f6\u7684\u4ea4\u8054\u8fde\u63a5\u65b9\u5f0f\u3002\u8fd9\u79cd\u65b9\u5f0f\u53ef\u4ee5\u5b9e\u73b0\u5f53\u6750\u6599\u5185\u90e8\u53d1\u751f\u8f83\u5927\u5f62\u53d8\u65f6\uff0c\u5f15\u8d77\u7684\u7f3a\u53e3\u533a\u57df\u5f97\u4ee5\u81ea\u6211\u4fee\u590d\u3002\u7531\u4e8e\u52a8\u6001RS-Ag\u76f8\u4e92\u4f5c\u7528\u7684\u5b58\u5728\uff0c\u8be5\u6c34\u51dd\u80f6\u6750\u6599\u663e\u793a\u51fa\u7531NIR\u6fc0\u5149\u548c\u9178\u6027\u6761\u4ef6\u8bf1\u5bfc\u7684\u5feb\u901f\u6709\u6548\u7684\u591a\u54cd\u5e94\u81ea\u6211\u4fee\u590d\u529f\u80fd\u3002\u6709\u8da3\u7684\u662f\uff0c\u4e00\u4e9b\u590d\u6742\u7684\u9a71\u52a8\u884c\u4e3a\uff0c\u4f8b\u5982\u4f7f\u7528\u673a\u68b0\u81c2\u62ac\u8d77\u548c\u6293\u53d6\u52a8\u4f5c\uff0c\u53ef\u4ee5\u901a\u8fc7\u8bf1\u5bfc\u6108\u5408\u5177\u6709\u4e0d\u540c\u7ed3\u6784\u7684\u6c34\u51dd\u80f6\u788e\u7247\u6765\u5b9e\u73b0\uff08\u9a71\u52a8\u8fc7\u7a0b\u53ef\u89c1\u56fe4\uff09\uff0c\u4ece\u800c\u5b9e\u73b0\u5177\u6709\u8fd0\u7528\u4ef7\u503c\u7684\u8f6f\u4f53\u9a71\u52a8\u5668\u3002\u5b9e\u9a8c\u7ed3\u679c\u663e\u793a\uff0c\u8be5\u6750\u6599\u5728\u673a\u68b0\uff0c\u5149\u5b66\uff0c\u81a8\u80c0\u548c\u6d88\u80c0\u884c\u4e3a\u4e0a\u7684\u5404\u5411\u5f02\u6027\u3002\u5176\u5e73\u884c\u65b9\u5411\u6a21\u91cf\u662f\u5782\u76f4\u65b9\u5411\u6a21\u91cf\u76843.9\u500d\u3002\u8be5\u5404\u5411\u5f02\u6027\u6c34\u51dd\u80f6\u6750\u6599\u5728\u672a\u6765\u7814\u7a76\u548c\u5f00\u53d1\u667a\u80fd\u673a\u5668\u4eba\u7b49\u9ad8\u7ea7\u8f6f\u4f53\u9a71\u52a8\u5668\u6709\u7740\u5de8\u5927\u7684\u6f5c\u529b\u3002<\/p>\n

\u56fe3\u00a0\u5408\u6210SNPP\u6c34\u51dd\u80f6\u6750\u6599\u7684\u56fe\u50cf\u793a\u610f\u56fe\u3002<\/p>\n

\"\"<\/p>\n

a Ag@BACA \u5fae\u7c92\u4e0eRS-Ag\u914d\u4f4d\u952e\u76f8\u8fde\uff1bb\u00a0\u5f53BACA\u5206\u5b50\u5438\u9644\u5230\u5fae\u7c92\u4e0a\u540e\uff0cS-S\u952e\u65ad\u5f00\uff0c\u5728\u7d2b\u5916\u7ebf\u5149\u7684\u7167\u5c04\u4e0b\uff0cBACA\u5206\u5b50\u91cd\u65b0\u6392\u5e03\uff0c\u5e76\u5728\u805a\u5408\u53cd\u5e94\u548c\u758f\u6c34\u4f5c\u7528\u4e0b\u4e8e\u6c34\u51dd\u80f6\u4e0a\u751f\u6210Ag\/PAM\u5c42\uff1bc\u00a0\u901a\u8fc7PAM\u6750\u6599\u94fe\u5f0f\u7ed3\u6784\u7684\u751f\u957f\u548c\u7d2b\u5916\u7ebf\u5149\u7684\u7167\u5c04\u4f5c\u7528\uff0c\u5404\u5411\u5f02\u6027\u7684\u6c34\u51dd\u80f6\u88ab\u51c6\u5907\u5b8c\u6210\uff1bd\u00a0\u6240\u5236\u5f97\u6750\u6599\u5728\u6536\u5230\u5916\u754c\u6eb6\u5242\u73af\u5883\u53d8\u5316\u65f6\u5f15\u8d77\u7684\u5b9a\u5411\u5f62\u53d8\u884c\u4e3a\u3002[3]<\/sup><\/p>\n

\u56fe4\u00a0\u8be5\u6c34\u51dd\u80f6\u6210\u679c\u5728\u8f6f\u4f53\u9a71\u52a8\u5668\u4e0a\u8fd0\u7528\u539f\u7406\u793a\u610f\u56fe\u3002<\/p>\n

\"\"<\/p>\n

\u5b9e\u9a8c\u56e2\u961f\u8bbe\u8ba1\u7684\u6c34\u51dd\u80f6\u5728\u53d7\u5230\u5916\u754c\u6eb6\u5242\u73af\u5883\u523a\u6fc0\u65f6\u4f1a\u5411\u5782\u76f4\u4e8e\u5c42\u72b6\u7ed3\u6784\u7684\u65b9\u5411\u5f2f\u66f2\uff08a\u00a0– d\uff09\u3002\u5b9e\u73b0\u56e2\u961f\u5229\u7528\u8fd9\u4e00\u7279\u6027\uff0c\u5c06\u6750\u6599\u788e\u7247\u6309\u7167\u4e0d\u540c\u7ed3\u6784\u65b9\u5411\u6574\u5408\u5b89\u88c5\uff08e\u548ci\uff09\uff0c\u4f7f\u96c6\u6210\u7ed3\u6784\u6709\u5b9a\u5411\u5f2f\u66f2\u5f62\u53d8\u7684\u80fd\u529b\uff0c\u4ece\u800c\u5b9e\u73b0\u8f6f\u4f53\u673a\u68b0\u81c2\u7684\u6293\u53d6\u884c\u4e3a\u3002[3]<\/sup><\/p>\n

4. \u53ef\u7528\u4e8e\u9aa8\u7ec4\u7ec7\u5de5\u7a0b\u7684\u591a\u5b54\u6c34\u51dd\u80f6<\/h3>\n

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\u56fe5\u00a0\u5185\u90e8\u8fde\u63a5\u7684\u5fae\u5b54\u72b6\u7ed3\u6784SEM\u56fe\u50cf\u3002\u56fe\u50cf\u5bf9\u5e94\u4e0d\u540c\u6bd4\u91cdMMT\u6750\u6599\u4e0b\u7684\u5fae\u89c2\u7ed3\u6784\u56fe\u3002[4]<\/sup><\/p>\n

\"\"<\/p>\n

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\u56fe6\u00a0\u6709\u673a\u6c34\u51dd\u80f6\u786c\u819c\u4e0b\u7535\u6781\u8bbe\u8ba1\u793a\u610f\u56fe\u53ca\u5176\u4f18\u70b9\u3002\u00a0[5]<\/sup><\/p>\n

\"\"<\/p>\n

\u53c2\u8003\u6587\u732e<\/h3>\n
    \n
  1. Chen, H., Cheng, R., Zhao, X., Zhang, Y., Tam, A., & Yan, Y. et al. (2019). An injectable self-healing coordinative hydrogel with antibacterial and angiogenic properties for diabetic skin wound repair. NPG Asia Materials, 11(1). doi: 10.1038\/s41427-018-0103-9<\/li>\n
  2. Hong, Y., Zhou, F., Hua, Y., Zhang, X., Ni, C., & Pan, D. et al. (2019). A strongly adhesive hemostatic hydrogel for the repair of arterial and heart bleeds. Nature Communications, 10(1). doi: 10.1038\/s41467-019-10004-7<\/li>\n
  3. Qin, H., Zhang, T., Li, N., Cong, H., & Yu, S. (2019). Anisotropic and self-healing hydrogels with multi-responsive actuating capability. Nature Communications, 10(1). doi: 10.1038\/s41467-019-10243-8<\/li>\n
  4. Cui, Z., Kim, S., Baljon, J., Wu, B., Aghaloo, T., & Lee, M. (2019). Microporous methacrylated glycol chitosan-montmorillonite nanocomposite hydrogel for bone tissue engineering. Nature Communications, 10(1). doi: 10.1038\/s41467-019-11511-3<\/li>\n
  5. Oribe, S., Yoshida, S., Kusama, S., Osawa, S., Nakagawa, A., & Iwasaki, M. et al. (2019). Hydrogel-Based Organic Subdural Electrode with High Conformability to Brain Surface.\u00a0Scientific Reports<\/i><\/em>,\u00a09<\/i><\/em>(1). doi: 10.1038\/s41598-019-49772-z<\/li>\n<\/ol>\n

    \u672c\u6587\u7531\u5143\u540c\u5b66\u4f9b\u7a3f\u3002<\/p>\n

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