{"id":187230,"date":"2019-10-11T06:30:43","date_gmt":"2019-10-10T22:30:43","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=187230"},"modified":"2019-10-10T16:55:47","modified_gmt":"2019-10-10T08:55:47","slug":"%e3%80%90%e5%b7%b2%e6%a0%a1%e7%a8%bf%e3%80%91nano-lett-%ef%bc%9a%e4%b8%80%e7%a7%8d%e6%96%b0%e5%9e%8b%e6%a0%b8%e5%a3%b3%e7%bb%93%e6%9e%84%e6%9d%90%e6%96%99%e7%94%a8%e4%ba%8enir-ii%e5%8c%ba%e5%8d%8f","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=187230","title":{"rendered":"Nano Lett.\uff1a\u4e00\u79cd\u65b0\u578b\u6838\u58f3\u7ed3\u6784\u6750\u6599\u7528\u4e8eNIR-II\u533a\u534f\u540c\u5149\u70ed\u5316\u5b66\u6cbb\u7597"},"content":{"rendered":"

\u3010\u7814\u7a76\u80cc\u666f\u3011<\/strong><\/p>\n

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\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u4e2d\u79d1\u9662\u957f\u6625\u5e94\u5316\u6240\u7a0b\u5b50\u6cf3\u7814\u7a76\u5458\u4e0e\u6797\u541b\u7814\u7a76\u5458<\/strong>\u5171\u540c\u4ee5\u661f\u5f62\u91d1\uff08Au-star\uff09\u7eb3\u7c73\u9897\u7c92\u4e3a\u7b2c\u4e8c\u8fd1\u7ea2\u5916\uff08NIR-II\uff09\u5149\u70ed\u5375\u9ec4\uff0c\u4ee5\u53ef\u751f\u7269\u964d\u89e3\u7684\u6676\u4f53\u6cb8\u77f3\u4e9a\u54aa\u5511\u9178\u76d0\u6676\u4f53\u9aa8\u67b6-8\uff08ZIF-8\uff09\u4e3a\u58f3\u5c42\uff0c\u6210\u529f\u6784\u5efa\u4e86\u4e00\u79cd\u65b0\u578b\u7684\u523a\u6fc0\u54cd\u5e94\u591a\u529f\u80fdYSNs\u3002\u5728\u8be5\u5e73\u53f0\u4e0a\uff0c\u5c06\u5316\u7597\u836f\u7269\u76d0\u9178\u963f\u9709\u7d20\uff08DOX\uff09\u5305\u57cb\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\uff0c\u663e\u793a\u4e86ZIF-8\u5728\u5fae\u73af\u5883\u4e2d\u964d\u89e3\u8fc7\u7a0b\u4e2d\u7684\u63a7\u91ca\u884c\u4e3a\u3002\u57281064 nm\uff08NIR-II\u7a97\u53e3\uff09\u6fc0\u5149\u7167\u5c04\u4e0b\uff0c\u661f\u5f62\u7eb3\u7c73\u91d1@ZIF-8\uff08Au@MOF\uff09\u5177\u6709\u4f18\u5f02\u7684\u5149\u70ed\u6548\u5e94\u548c\u4fc3\u8fdb\u836f\u7269\u91ca\u653e\u7684\u534f\u540c\u6297\u764c\u6548\u5e94\u3002\u6b64\u5916\uff0c\u5f3a\u70c8\u7684\u8fd1\u7ea2\u5916\u533a\u57df\u5438\u6536\u8d4b\u4e88\u4e86\u8fd1\u7ea2\u5916\u70ed\u6210\u50cf\u548c\u5149\u58f0\uff08PA\uff09\u6210\u50cf\u7684Au@MOF\u7279\u6027\u3002\u8fd9\u9879\u5de5\u4f5c\u6709\u52a9\u4e8e\u8bbe\u8ba1\u4e00\u79cd\u523a\u6fc0\u54cd\u5e94\u7684\u201c\u4e00\u4f53\u5f0f\u201d\u7eb3\u7c73\u8f7d\u4f53\uff0c\u5b9e\u73b0\u53cc\u5cf0\u6210\u50cf\u8bca\u65ad\u548c\u5316\u5b66\u5149\u70ed\u534f\u540c\u6cbb\u7597\u3002\u8be5\u6587\u7ae0\u8fd1\u65e5\u4ee5\u9898\u4e3a\u201cYolk\u2212Shell Structured Au Nanostar@Metal\u2212Organic Framework for Synergistic Chemo-photothermal Therapy in the Second NearInfrared Window<\/strong>\u201d\u53d1\u8868\u5728\u77e5\u540d\u671f\u520aNano Letters<\/strong>\u4e0a\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe\u4e00\u3001\u6750\u6599\u5236\u5907\u53ca\u4f5c\u7528\u8fc7\u7a0b\u793a\u610f\u56fe<\/strong><\/p>\n

\"\"<\/p>\n

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\u56fe\u4e8c\u3001<\/strong>Au@MOF<\/strong>\u7eb3\u7c73\u6750\u6599\u7684\u8868\u5f81<\/strong><\/p>\n

\"\"<\/p>\n

\uff08A-C\uff09\u661f\u5f62\u7eb3\u7c73Au\u3001Au@MOF\u3001\u6838\u58f3\u7ed3\u6784Au@MOF\u7684TEM\u56fe\u50cf\u3002\uff08D-E\uff09Au@MOF\u3001\u6838\u58f3\u7ed3\u6784Au@MOF\u7684SEM\u56fe\u50cf\u3002<\/p>\n

\uff08F-H\uff09Au@MOF\u7684EDS\u5143\u7d20mapping\u56fe\u3002<\/p>\n

\u56fe\u4e09\u3001<\/strong>Au@MOF<\/strong>\u7684\u5149\u70ed\u6027\u80fd<\/strong><\/p>\n

\"\"<\/p>\n

\uff08A\uff09808 nm\u5149\u7167\u4e0b\uff0cAu@MOF\u7684\u5149\u70ed\u7a33\u5b9a\u6027\u6d4b\u8bd5\u3002<\/p>\n

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\uff08D\uff091064 nm\u5149\u7167\u4e0b\uff0cAu@MOF\u7684\u5149\u70ed\u7a33\u5b9a\u6027\u6d4b\u8bd5\u3002<\/p>\n

\uff08E\uff091064 nm\u5149\u7167\u4e0b\uff0c\u4e0d\u540c\u6d53\u5ea6Au@MOF\u7684\u5149\u70ed\u6027\u80fd\u3002<\/p>\n

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\u56fe\u56db\u3001\u4f53\u5916\u6297\u80bf\u7624\u5b9e\u9a8c\u53ca\u4f53\u5185\u5149\u70ed\u6210\u50cf\u5b9e\u9a8c<\/strong><\/p>\n

\"\"<\/p>\n

\uff08A\uff09\u5728\u6709\u6216\u65e01064 nm\u6fc0\u5149\u5f15\u53d1DOX\u91ca\u653e\u7684\u60c5\u51b5\u4e0b\uff0cHela\u7ec6\u80de\u4e0eAu@MOF-DOX\u957f\u5b75\u80b2\u7684CLSM\u56fe\u50cf\u3002<\/p>\n

\uff08B\uff09\u5728\u4e0d\u540c\u91d1\u6d53\u5ea6\uff080.0313\u30010.0625\u30010.125\u30010.25\u30010.5\u548c1.0mg\u00b7ml-1<\/sup>\uff09\u4e0b\uff0c\u7528Au@MOF\u5b75\u80b2L929\u7ec6\u80de24 h\u548c48 h\u7ec6\u80de\u6bd2\u6027\u3002<\/p>\n

\uff08C\uff09\u5206\u522b\u4e0eDOX\u3001Au@MOF\u548cAu@MOF-DOX\u57281064nm\u6fc0\u5149\u548c\u65e01064nm\u6fc0\u5149\u4f5c\u7528\u4e0b\u5b75\u80b2Hela\u7ec6\u80de\u540e\u7684\u5b58\u6d3b\u7387\u3002<\/p>\n

\uff08D\uff090.8w\u00b7cm-2<\/sup> 1064 nm\u6fc0\u5149\u7167\u5c04\u7eaf\u6c34\u548cAu@MOF\u6eb6\u6db25min\u7684\u7ea2\u5916\u70ed\u50cf\u56fe\u3002<\/p>\n

\uff08E\uff09\u4e0d\u540c\u65f6\u95f4\u95f4\u9694\uff08e\uff09\u9759\u8109\u6ce8\u5c04Au@MOF\u540eAu\u5728\u5c0f\u9f20\u80bf\u7624\u53ca\u4e3b\u8981\u810f\u5668\u4e2d\u7684\u751f\u7269\u5206\u5e03\u3002<\/p>\n

\uff08F\uff090.8w\u00b7cm-2<\/sup> 1064 nm\u6fc0\u5149\u6fc0\u6d3bPBS\u6216Au@MOF\u9759\u6ce8H22\u8377\u7624\u5c0f\u9f205min\u7684\u4f53\u5185\u7ea2\u5916\u70ed\u50cf\u56fe\u3002<\/p>\n

\uff08G\uff09\u4e0d\u540c\u65f6\u95f4\u70b9\u9759\u8109\u6ce8\u5c04Au@MOF\u7684balb\/c\u88f8\u9f20\u4f53\u5185PAI\u56fe\u50cf\u3002<\/p>\n

\u56fe\u4e94\u3001<\/strong>Au@MOF-DOX<\/strong>\u4f53\u5185\u6297\u80bf\u7624\u6548\u679c<\/strong><\/p>\n

\"\"<\/p>\n

\uff08A\uff09\u4e0d\u540c\u7ec4\u8377\u7624\u5c0f\u9f20\u7684\u4f53\u91cd\u53d8\u5316\u3002<\/p>\n

\uff08B\uff09\u4e0d\u540c\u7ec4\u8377\u7624\u5c0f\u9f20\u7684\u80bf\u7624\u4f53\u79ef\u53d8\u5316\u3002<\/p>\n

\uff08C\uff09\u8377\u7624\u5c0f\u9f20\u7ecf\u4e0d\u540c\u5904\u7406\u540e\u7684\u4ee3\u8868\u6027\u7167\u7247\u3002<\/p>\n

\uff08D\uff09\u5404\u7ec4\u80bf\u7624\u5207\u7247H&E\u67d3\u8272\u56fe\u50cf\u3002<\/p>\n

\uff08E\uff09Au@MOF-DOX\u8fd1\u7ea2\u5916\u7167\u5c04\u540e\uff0cPBS\u5904\u7406\u540e\u7684\u5c0f\u9f20\u4e3b\u8981\u810f\u5668H&E\u67d3\u8272\u5207\u7247\u3002<\/p>\n

\u3010\u7ed3\u8bba\u5c55\u671b\u3011<\/strong><\/p>\n

\u7efc\u4e0a\u6240\u8ff0\uff0c\u4f5c\u8005\u6210\u529f\u5236\u5907\u4e86\u65b0\u578b\u6838\u58f3Au@MOF\u7eb3\u7c73\u8f7d\u4f53\uff0c\u8be5\u8f7d\u4f53\u5177\u6709\u9ad8\u7684\u6297\u764c\u836f\u7269\u9012\u9001\u80fd\u529b\u3001pH\u654f\u611f\u6027\u836f\u7269\u91ca\u653e\u3001\u4f18\u8d8a\u7684NIR-II\u53cd\u5e94\u5149\u70ed\u8f6c\u6362\u80fd\u529b\u4ee5\u53ca\u826f\u597d\u7684\u751f\u7269\u76f8\u5bb9\u6027\u3002\u4e0eNIR-I\u6fc0\u5149\u76f8\u6bd4\uff0cNIR-II\u6fc0\u5149\u53ef\u4ee5\u5b9e\u73b0\u66f4\u6df1\u7684\u7ec4\u7ec7\u7a7f\u900f\u548c\u66f4\u9ad8\u7684\u65f6\u7a7a\u5206\u8fa8\u7387\u3002\u57281064 nm\u6fc0\u5149\u7167\u5c04\u4e0b\uff0c\u6838\u58f3Au@MOF\u7684\u5149\u70ed\u8f6c\u5316\u6548\u7387\u660e\u663e\u9ad8\u4e8eNIR-I\u3002\u6b64\u5916\uff0c\u8054\u5408\u5316\u7597\u5149\u70ed\u7597\u6cd5\u5728\u6291\u5236\u80bf\u7624\u751f\u957f\u65b9\u9762\u5177\u6709\u663e\u8457\u7684\u534f\u540c\u6548\u5e94\u3002\u540c\u65f6\uff0c\u7ea2\u5916\/PAI\u6210\u50cf\u5728\u5f71\u50cf\u5f15\u5bfc\u4e0b\u7684\u76d1\u6d4b\u548c\u6cbb\u7597\u4e2d\u663e\u793a\u51fa\u5176\u4f18\u8d8a\u6027\u3002\u6b64\u5916\uff0c\u672c\u7814\u7a76\u4e3a\u6784\u5efa\u57fa\u4e8eMOF\u7684\u6838\u58f3\u7eb3\u7c73\u8f7d\u4f53\u63d0\u4f9b\u4e86\u4e00\u79cd\u53ef\u884c\u7684\u65b9\u6cd5\uff0c\u53ef\u7528\u4e8e\u836f\u7269\u9012\u9001\u548c\u5176\u4ed6\u53ef\u80fd\u7684\u5e94\u7528\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aYolk\u2212Shell Structured Au Nanostar@Metal\u2212Organic Framework for Synergistic Chemo-photothermal Therapy in the Second NearInfrared Window<\/a> (Nano Letters<\/em> 2019<\/strong>, DOI: 10.1021\/acs.nanolett.9b01716)<\/p>\n

\u672c\u6587\u7531\u5927\u5175\u54e5\u4f9b\u7a3f\u3002<\/p>\n

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