{"id":187889,"date":"2019-10-23T14:36:38","date_gmt":"2019-10-23T06:36:38","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=187889"},"modified":"2019-10-23T14:36:38","modified_gmt":"2019-10-23T06:36:38","slug":"acs-nano%ef%bc%9a%e8%82%bd%e5%9f%ba%e8%87%aa%e7%bb%84%e8%a3%85%e4%bd%93%e9%87%8d%e5%a1%91%e5%89%8d%e5%88%97%e8%85%ba%e8%82%bf%e7%98%a4%e5%be%ae%e7%8e%af%e5%a2%83%e6%8a%91%e5%88%b6%e8%82%bf%e7%98%a4","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=187889","title":{"rendered":"ACS Nano\uff1a\u80bd\u57fa\u81ea\u7ec4\u88c5\u4f53\u91cd\u5851\u524d\u5217\u817a\u80bf\u7624\u5fae\u73af\u5883\u6291\u5236\u80bf\u7624\u8f6c\u79fb"},"content":{"rendered":"<p><strong>\u3010\u7814\u7a76\u80cc\u666f\u3011<\/strong><\/p>\n<p>\u524d\u5217\u817a\u764c\u662f\u897f\u65b9\u56fd\u5bb6\u7537\u6027\u4e2d\u6700\u5e38\u89c1\u7684\u6076\u6027\u80bf\u7624\u4e4b\u4e00\uff0c\u4e5f\u662f\u764c\u75c7\u76f8\u5173\u6b7b\u4ea1\u7684\u7b2c\u4e8c\u5927\u4e3b\u8981\u539f\u56e0\u3002\u867d\u7136\u76ee\u524d\u524d\u5217\u817a\u7684\u6cbb\u7597\u53d6\u5f97\u4e86\u4e00\u5b9a\u6210\u5c31\uff0c\u4f46\u662f\u4ecd\u7136\u7f3a\u4e4f\u6709\u6548\u7684\u9488\u5bf9\u6076\u6027\u8f6c\u79fb\u524d\u5217\u817a\u764c\u7684\u6cbb\u7597\u65b9\u6cd5\uff0c\u8fd9\u4e5f\u662f\u665a\u671f\u524d\u5217\u817a\u764c\u5bfc\u81f4\u6bc1\u706d\u6027\u5e76\u53d1\u75c7\u548c\u6b7b\u4ea1\u7684\u539f\u56e0\u3002\u636e\u62a5\u9053\uff0c\u80bf\u7624\u7ec6\u80de\u7684\u4fb5\u88ad\u548c\u8fc1\u79fb\u4ee5\u53ca\u8840\u7ba1\u751f\u6210\u662f\u80bf\u7624\u8f6c\u79fb\u7684\u5173\u952e\u4e8b\u4ef6\uff0c\u800c\u80bf\u7624\u76f8\u5173\u7684\u6210\u7ea4\u7ef4\u7ec6\u80de\uff08CAFs\uff09\u662f\u8fd9\u4e9b\u4e8b\u4ef6\u4e2d\u7684\u5173\u952e\u542f\u52a8\u5b50\uff0c\u5b83\u901a\u8fc7\u6539\u53d8\u524d\u5217\u817a\u764c\u7684\u5fae\u73af\u5883\u53d1\u6325\u4f5c\u7528\u3002\u56e0\u6b64\uff0c\u51cf\u5c11CAFs\u6216\u9006\u8f6c\u5176\u529f\u80fd\u5e94\u8be5\u662f\u6291\u5236\u80bf\u7624\u8f6c\u79fb\u7684\u53ef\u884c\u7b56\u7565\u3002\u524d\u671f\u7814\u7a76\u8868\u660e\uff0c\u6d88\u9664CAFs\u53ef\u4ee5\u63d0\u9ad8\u524d\u5217\u817a\u80bf\u7624\u5316\u7597\u7684\u7597\u6548\u3002\u7136\u800c\uff0c\u6700\u8fd1\u7684\u7814\u7a76\u8868\u660e\uff0c\u03b1\u5e73\u6ed1\u808c\u808c\u52a8\u86cb\u767d\uff08<em>\u03b1<\/em>-SMA\uff09<sup>+<\/sup>\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u7f3a\u5931\u589e\u52a0\u4e86\u80bf\u7624\u4fb5\u88ad\u6216\u8f6c\u79fb\u7684\u98ce\u9669\u3002\u56e0\u6b64\uff0c\u4e3a\u4e86\u907f\u514d\u6f5c\u5728\u7684\u98ce\u9669\uff0c\u901a\u8fc7\u8c03\u8282CAFs\u7684\u529f\u80fd\u800c\u4e0d\u662f\u76f4\u63a5\u6d88\u8017CAFs\u6765\u63a2\u7d22\u8f6c\u79fb\u6291\u5236\u662f\u4e00\u79cd\u6709\u8f83\u5927\u524d\u666f\u7684\u7b56\u7565\u3002<\/p>\n<p><strong>\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n<p>\u8fd1\u65e5\uff0c<strong>\u56fd\u5bb6\u7eb3\u7c73\u4e2d\u5fc3<\/strong><strong>Ji Tianjiao<\/strong><strong>\u7814\u7a76\u5458<\/strong><strong>\u3001\u8d75\u9896\u7814\u7a76\u5458\u548c\u8042\u5e7f\u519b\u7814\u7a76\u5458<\/strong>\u901a\u8fc7\u5c06\u6210\u7ea4\u7ef4\u7ec6\u80de\u6d3b\u5316\u86cb\u767d-\u03b1\uff08FAP-\u03b1\uff09\u6297\u4f53\u52a0\u8f7d\u5230\u7ec6\u80de\u7a7f\u900f\u80bd\uff08CPP\uff09\u4e3a\u57fa\u7840\u7684\u7eb3\u7c73\u9897\u7c92\u4e0a\uff0c\u6784\u5efa\u4e86\u4e00\u4e2aCAF\u9776\u5411siRNA\u9012\u9001\u7cfb\u7edf\uff0c\u8be5\u7eb3\u7c73\u7c92\u5728CAFs\u4e2d\u7279\u5f02\u6027\u4e0b\u8c03\u4e86C-X-C\u57fa\u5e8f\u8d8b\u5316\u56e0\u5b50\u914d\u4f5312\uff08CXCL12\uff09\u7684\u8868\u8fbe\u3002\u8fd9\u79cd\u8c03\u8282\u901a\u8fc7\u706d\u6d3bCAFs\u800c\u4ea7\u751f\u4e00\u7cfb\u5217\u53d8\u5316\uff0c\u4ece\u800c\u91cd\u5851\u524d\u5217\u817a\u764c\u7684\u5fae\u73af\u5883\u3002\u80bf\u7624\u7ec6\u80de\u7684\u4fb5\u88ad\u3001\u8fc1\u79fb\u548c\u8840\u7ba1\u751f\u6210\u5747\u53d7\u5230\u660e\u663e\u6291\u5236\uff0c\u8fd9\u90fd\u6709\u52a9\u4e8e\u6291\u5236\u539f\u4f4d\u524d\u5217\u817a\u80bf\u7624\u7684\u8f6c\u79fb\u3002\u8fd9\u79cd\u901a\u8fc7CAF\u9776\u5411\u548c\u706d\u6d3b\u7684\u80bf\u7624\u5fae\u73af\u5883\u91cd\u5851\u7b56\u7565\u4e3a\u6291\u5236\u524d\u5217\u817a\u764c\u8f6c\u79fb\u63d0\u4f9b\u4e86\u4e00\u79cd\u65b0\u7684\u9014\u5f84\u3002\u8be5\u6587\u7ae0\u8fd1\u65e5\u4ee5\u9898\u4e3a\u201c<strong>Reshaping Prostate Tumor Microenvironment To Suppress Metastasis via Cancer-Associated Fibroblast Inactivation with Peptide-Assembly-Based Nanosystem<\/strong>\u201d\u53d1\u8868\u5728\u77e5\u540d\u671f\u520a<strong>ACS Nano<\/strong>\u4e0a\u3002<\/p>\n<p><strong>\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n<p><strong>\u56fe\u4e00\u3001<\/strong><strong>PNP\/siCXCL12\/mAb<\/strong><strong>\u7eb3\u7c73\u4f53\u7cfb\u7ed3\u6784\u4e0e\u5de5\u4f5c\u673a\u7406\u793a\u610f\u56fe<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-187890\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/10\/1-1.jpeg\" alt=\"\" width=\"600\" height=\"683\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/10\/1-1.jpeg 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/10\/1-1-264x300.jpeg 264w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\uff08A\uff09\u901a\u8fc7\u8d85\u5206\u5b50\u7ec4\u88c5\u6784\u5efaPNP\/siRNA\/mAb\u7eb3\u7c73\u4f53\u7cfb\uff1b<\/p>\n<p>\uff08B\uff09\u63d0\u51faPNP\/siCXCL12\/mAb\u4ecb\u5bfc\u7684\u8f6c\u79fb\u6291\u5236\u548cCPP\u4ecb\u5bfc\u7684CXCL12 siRNA\u8f6c\u67d3CAFs\u7684\u673a\u5236\u3002<\/p>\n<p><strong>\u56fe\u4e8c\u3001\u7eb3\u7c73\u4f53\u7cfb\u7684\u5236\u5907\u53ca\u8868\u5f81<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-187891\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/10\/1-2.jpeg\" alt=\"\" width=\"600\" height=\"526\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/10\/1-2.jpeg 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/10\/1-2-300x263.jpeg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\uff08A\uff09\u4e0d\u540c\u8d28\u91cf\u6bd4\u7684PNP\/siRNA\u590d\u5408\u7269\u7684\u7535\u6cf3\u8fc1\u79fb\u7387\uff1b<\/p>\n<p>\uff08B\uff09siRNA\u88abPNP\u5438\u9644\u524d\u540e\u5bf9RNase\u7684\u7a33\u5b9a\u6027\uff1b<\/p>\n<p>\uff08C-D\uff09PNP\/siRNA\/mAb\u548cPNP\/siRNA\/IgG\u5728\u4e0d\u540c\u6bd4\u4f8bPNP\u548cmAb\uff08\u6216IgG\uff09\u65f6\u7684Zeta\u7535\u4f4d\u3002<\/p>\n<p>\uff08E\uff09\u901a\u8fc7TEM\u89c2\u5bdf\u7684\u4f18\u5316\u7684PNP\/siRNA\/mAb\u548cPNP\/siRNA\/IgG\u7684\u5f62\u6001\u3002<\/p>\n<p>\uff08F\uff09\u901a\u8fc7DLS\u6d4b\u91cf\u7684PNP\/siRNA\/mAb\u548cPNP\/siRNA\/IgG\u7684\u7c92\u5f84\u3002<\/p>\n<p><strong>\u56fe\u4e09\u3001\u7eb3\u7c73\u4f53\u7cfb\u7684\u7ec6\u80de\u6444\u53d6\u548c\u57fa\u56e0\u6c89\u9ed8\u6548\u7387<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-187892\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/10\/2-1.jpeg\" alt=\"\" width=\"600\" height=\"733\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/10\/2-1.jpeg 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/10\/2-1-246x300.jpeg 246w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\uff08A\uff09\u6d41\u5f0f\u7ec6\u80de\u672f\u5206\u6790FAM-siRNA\u5728CAFs\uff08FAP-\u03b1\u9633\u6027\uff09\u548cPC-3\uff08FAP-\u03b1\u9634\u6027\uff09\u7ec6\u80de\u4e2d\u7684\u5185\u5316\uff1b<\/p>\n<p>\uff08B\uff09\u4e0d\u540c\u914d\u65b9\u5904\u7406\u7684CAFs\u548cPC-3\u7ec6\u80de\u7684\u5e73\u5747\u8367\u5149\u5f3a\u5ea6\uff1b<\/p>\n<p>\uff08C\uff09\u4eceCLSM\u56fe\u50cf\u4e2d\u7814\u7a76\u6bcf\u79cd\u6750\u6599\u7684\u7ec6\u80de\u6444\u53d6\uff1b<\/p>\n<p>\uff08D\uff09\u4e0d\u540c\u65f6\u95f4PNP\/siRNA\/mAb\u5b75\u80b2\u7684CAFs\u4e2dFAM-siRNA\u7684\u5206\u5e03\uff1b<\/p>\n<p>\uff08E\uff09PCR\u68c0\u6d4bCAFs\u4e2dCXCL12 mRNA\u8868\u8fbe\u6c34\u5e73\uff1b<\/p>\n<p>\uff08F\uff09CAF\u4e2dCXCL12\u6d53\u5ea6\uff1b<\/p>\n<p>\uff08G\uff09\u7528WB\u68c0\u6d4b\u4e0d\u540c\u914d\u65b9\u5904\u7406\u7684CAFs\u4e2dCXCL 12\u7684\u8868\u8fbe\uff1b<\/p>\n<p>\uff08H\uff09WB\u7ed3\u679c\u4e2d\u6807\u51c6\u5316CXCL 12\u86cb\u767d\u8868\u8fbe\u7684\u5b9a\u91cf\u5206\u6790\u3002<\/p>\n<p><strong>\u56fe\u56db\u3001<\/strong><strong>CAFs<\/strong><strong>\u6d3b\u6027\u53ca\u5206\u6ccc\u60c5\u51b5\u7684\u53d8\u5316<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-187893\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/10\/3-1.jpeg\" alt=\"\" width=\"600\" height=\"802\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/10\/3-1.jpeg 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/10\/3-1-224x300.jpeg 224w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\uff08A\uff09\u4e0d\u540c\u6cbb\u7597\u7ec4CAFs\u7684\u03b1-SMA\u514d\u75ab\u8367\u5149\u67d3\u8272\u7684CLSM\u56fe\u50cf\uff1b<\/p>\n<p>\uff08B\uff09\uff08A\uff09\u4e2d\u7ed3\u679c\u7684\u6807\u51c6\u5316\u03b1-SMA\u8868\u8fbe\u7684\u5b9a\u91cf\u5206\u6790\uff1b<\/p>\n<p>\uff08C\uff09\u4e0d\u540c\u6cbb\u7597\u7ec4CAFs\u7ec6\u80de\u5468\u671f\u5206\u6790\uff1b<\/p>\n<p>\uff08D\uff09\u5728G0\/G1\u3001S\u548cG2\/M\u65f6\u505c\u6ede\u7684\u7ec6\u80de\u767e\u5206\u6bd4\uff1b<\/p>\n<p>\uff08E\uff09\u86cb\u767d\u8d28\u7ec4\u82af\u7247\u68c0\u6d4bCAFs\u6cbb\u7597\u540e\u7ec6\u80de\u56e0\u5b50\u7684\u5dee\u5f02\u8868\u8fbe\uff1b<\/p>\n<p>\uff08F\uff09\u8840\u7ba1\u751f\u6210\u86cb\u767d\u9635\u5217\u82af\u7247\u68c0\u6d4bCAFs\u6cbb\u7597\u540e\u8840\u7ba1\u751f\u6210\u76f8\u5173\u56e0\u5b50\u7684\u5dee\u5f02\u8868\u8fbe\u3002<\/p>\n<p><strong>\u56fe\u4e94\u3001\u80bf\u7624\u7ec6\u80de\u8fc1\u79fb\u548c\u4fb5\u88ad\u80fd\u529b\u8bc4\u4f30<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-187895\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/10\/4-1.jpeg\" alt=\"\" width=\"600\" height=\"833\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/10\/4-1.jpeg 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/10\/4-1-216x300.jpeg 216w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\uff08A\uff09\u7528\u4e8e\u8fc1\u79fb\u8bc4\u4f30\u7684\u4f24\u53e3\u6108\u5408\u5b9e\u9a8c\u65b9\u6848\uff1b<\/p>\n<p>\uff08B-C\uff09\u6bcf\u4e2aCAF-CM\u6cbb\u7597\u524d\u540e\u7684\u4f24\u53e3\u56fe\u50cf\u548c\u504f\u79fb\u8ddd\u79bb\u7684\u91cf\u5316\u5206\u6790\uff1b<\/p>\n<p>\uff08D\uff09\u80bf\u7624\u7ec6\u80de\u4fb5\u88ad\u6a21\u578b\u7684\u5efa\u7acb\uff1b<\/p>\n<p>\uff08E-F\uff09\u5404\u7ec4PC-3\u7ec6\u80de\u6d78\u6da6\u7684\u56fe\u50cf\u53ca\u5b9a\u91cf\u5206\u6790\u3002<\/p>\n<p><strong>\u56fe\u516d\u3001\u5185\u76ae\u7ec6\u80de\u529f\u80fd\u8bc4\u4ef7<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-187894\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/10\/5-1.jpeg\" alt=\"\" width=\"600\" height=\"712\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/10\/5-1.jpeg 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/10\/5-1-253x300.jpeg 253w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\uff08A\uff09\u4eceTranswell\u8bd5\u9a8c\u4e2d\u83b7\u5f97\u7684CAF 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href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acsnano.9b04857\">Reshaping Prostate Tumor Microenvironment To Suppress Metastasis via Cancer-Associated Fibroblast Inactivation with Peptide-Assembly-Based Nanosystem<\/a> (<em>ACS Nano<\/em> <strong>2019<\/strong>, DOI: 10.1021\/acsnano.9b04857)<\/p>\n<p>\u672c\u6587\u7531\u5927\u5175\u54e5\u4f9b\u7a3f\u3002<\/p>\n<p>\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1\uff1a<a href=\"mailto:tougao@cailiaoren.com\">tougao@cailiaoren.com<\/a><\/p>\n<p>\u6295\u7a3f\u4ee5\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1acailiaokefu<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u7814\u7a76\u80cc\u666f\u3011 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