{"id":192073,"date":"2019-12-22T06:07:51","date_gmt":"2019-12-21T22:07:51","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=192073"},"modified":"2019-12-21T21:08:07","modified_gmt":"2019-12-21T13:08:07","slug":"%e6%9d%8e%e4%ba%9a%e5%b9%b3%e4%ba%8e%e6%b5%b7%e5%86%9bnano-lett-%ef%bc%9a%e5%89%8d%e8%8d%af%e5%9b%8a%e6%b3%a1%e7%94%a8%e4%ba%8e%e8%82%bf%e7%98%a4%e7%9a%84%e5%85%89%e5%8a%a8%e5%8a%9b%e5%85%8d%e7%96%ab","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=192073","title":{"rendered":"\u674e\u4e9a\u5e73&#038;\u4e8e\u6d77\u519bNano Lett.\uff1a\u524d\u836f\u56ca\u6ce1\u7528\u4e8e\u80bf\u7624\u7684\u5149\u52a8\u529b\u514d\u75ab\u6cbb\u7597"},"content":{"rendered":"<p><strong>\u3010\u7814\u7a76\u80cc\u666f\u3011<\/strong><\/p>\n<p>\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\uff08ICB\uff09\u6cbb\u7597\u5728\u8f6c\u79fb\u6027\u6216\u665a\u671f\u80bf\u7624\u7684\u4e34\u5e8a\u6cbb\u7597\u4e2d\u5f15\u8d77\u4e86\u5e7f\u6cdb\u5173\u6ce8\u3002ICB\u7597\u6cd5\u53ef\u4ee5\u8bf1\u5bfc\u9488\u5bf9\u80bf\u7624\u6d88\u9000\u7684\u5168\u8eab\u4fdd\u62a4\u6027\u514d\u75ab\u5e94\u7b54\uff0c\u4f46\u662f\u7531\u4e8e\u80bf\u7624\u7ec6\u80de\u7684\u514d\u75ab\u539f\u6027\u4f4e\u548c\u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de\uff08CTL\uff09\u7684\u80bf\u7624\u5185\u6d78\u6da6\u4e0d\u8db3\uff0c\u53ea\u6709\u4e00\u90e8\u5206\u764c\u75c7\u60a3\u8005\u5bf9\u76ee\u524d\u7684ICB\u6cbb\u7597\u6709\u53cd\u5e94\u3002\u7814\u7a76\u8005\u4eec\u76ee\u524d\u5df2\u5f00\u53d1\u51fa\u5305\u62ec\u5316\u5b66\u7597\u6cd5\u3001\u653e\u5c04\u7597\u6cd5\u548c\u5149\u52a8\u529b\u7597\u6cd5\uff08PDT\uff09\u5728\u5185\u7684\u51e0\u79cd\u6cbb\u7597\u65b9\u5f0f\u6765\u5f15\u53d1\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u3002PDT\u53ef\u4ee5\u8bf1\u5bfc\u6d3b\u6027\u6c27\uff08ROS\uff09\u751f\u6210\uff0c\u4ece\u800c\u89e6\u53d1\u514d\u75ab\u539f\u6027\u7ec6\u80de\u6b7b\u4ea1\uff08ICD\uff09\u7ea7\u8054\u53cd\u5e94\u3002\u7ecf\u5386ICD\u7684\u80bf\u7624\u7ec6\u80de\u5728\u7ec6\u80de\u819c\u8868\u9762\u8868\u8fbe\u9499\u7f51\u86cb\u767d\uff08CRT\uff09\uff0c\u5e76\u5206\u6ccc\u9ad8\u8fc1\u79fb\u7387\u7ec4\u86cb\u767d1\uff08HMGB1\uff09\u86cb\u767d\u548c\u4e09\u78f7\u9178\u817a\u82f7\uff08ATP\uff09\u52df\u96c6CTL\u3002\u6b64\u5916\uff0c\u4e00\u4e9b\u7814\u7a76\u8868\u660e\uff0cPDT\u53ef\u901a\u8fc7\u4e0a\u8c03\u4fc3\u708e\u56e0\u5b50\uff08\u5982\u70ed\u4f11\u514b\u86cb\u767d70\uff08HSP70\uff09\u548c\u8f6c\u5f55\u56e0\u5b50\u6838\u56e0\u5b50\u03baB\uff08NF-kB\uff09\u7684\u8868\u8fbe\u6765\u89e6\u53d1\u514d\u75ab\u53cd\u5e94\u3002<\/p>\n<p><strong>\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n<p>\u8fd1\u65e5\uff0c<strong>\u4e2d\u79d1\u9662\u4e0a\u6d77\u836f\u7269\u7814\u7a76\u6240\u674e\u4e9a\u5e73\u7814\u7a76\u5458\u548c\u4e8e\u6d77\u519b\u7814\u7a76\u5458<\/strong>\u8054\u5408\u8bc1\u660e\u4e86\u901a\u8fc7\u6291\u5236\u5432\u54da\u80fa2\uff0c3-\u4e8c\u52a0\u6c27\u91761\uff08IDO-1\uff09\u53ef\u4ee5\u514b\u670d\u514d\u75ab\u8010\u53d7\u3002\u4f5c\u8005\u901a\u8fc7\u6574\u5408PEG\u5316\u5149\u654f\u5242\uff08PS\uff09\u548cIDO-1\u6291\u5236\u5242\u7684\u8fd8\u539f\u654f\u611f\u6027\u524d\u836f\uff0c\u5408\u7406\u8bbe\u8ba1\u4e86\u53ef\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u8131\u843d\u7684\u524d\u836f\u56ca\u6ce1\u3002\u524d\u836f\u56ca\u6ce1\u5728\u8840\u6db2\u5faa\u73af\u4e2d\u662f\u60f0\u6027\u7684\uff0c\u800c\u5b83\u4eec\u901a\u8fc7MMP-2\u4ecb\u5bfc\u7684PEG\u88c2\u89e3\u7279\u5f02\u6027\u5730\u805a\u96c6\u5728\u80bf\u7624\u90e8\u4f4d\uff0c\u4ece\u800c\u5b9e\u73b0\u4e86\u8367\u5149\u6210\u50cf\u5f15\u5bfc\u7684PDT\u3002\u4e0e\u5355\u72ec\u7684PDT\u76f8\u6bd4\uff0c\u524d\u836f-\u56ca\u6ce1\u4ecb\u5bfc\u7684\u8054\u5408\u514d\u75ab\u7597\u6cd5\u5728CT26\u5927\u80a0\u548c4T1\u4e73\u817a\u514d\u75ab\u529f\u80fd\u6b63\u5e38\u7684\u5c0f\u9f20\u6a21\u578b\u4e2d\u5747\u589e\u5f3a\u4e86\u6297\u80bf\u7624\u514d\u75ab\u529b\u3002\u524d\u836f\u56ca\u6ce1\u663e\u8457\u6291\u5236\u4e86\u80bf\u7624\u590d\u53d1\u3002\u8be5\u6587\u7ae0\u8fd1\u65e5\u4ee5\u9898\u4e3a\u201c<strong>Sheddable Prodrug Vesicles Combating Adaptive Immune Resistance for Improved Photodynamic Immunotherapy of Cancer<\/strong>\u201d\u53d1\u8868\u5728\u77e5\u540d\u671f\u520a<strong>Nano Lett.<\/strong>\u4e0a\u3002<\/p>\n<p><strong>\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n<p><strong>\u56fe\u4e00\u3001\u7eb3\u7c73\u6750\u6599\u5236\u5907\u53ca\u7ec6\u80de\u4f5c\u7528\u8fc7\u7a0b\u793a\u610f\u56fe<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-192074\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/12\/1-14.jpg\" alt=\"\" width=\"600\" height=\"661\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/12\/1-14.jpg 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/12\/1-14-272x300.jpg 272w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\uff08a\uff09\u7528\u4e8e\u7ec4\u5408\u5149\u52a8\u529b\u514d\u75ab\u7597\u6cd5\u7684MMP-2\u54cd\u5e94\u8131\u843d\u548cGSH\u6d3b\u5316\u7684\u524d\u836f\u56ca\u6ce1\u7684\u793a\u610f\u56fe\uff1b\uff08b\uff09EAPV\u4ecb\u5bfc\u7684\u5149\u52a8\u529b\u514d\u75ab\u6cbb\u7597\u7684\u673a\u5236\u3002<\/p>\n<p><strong>\u56fe\u4e8c\u3001<\/strong><strong>EAPV<\/strong><strong>\u7684\u5316\u5b66\u7269\u7406\u8868\u5f81<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-192075\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/12\/2-14.jpg\" alt=\"\" width=\"600\" height=\"438\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/12\/2-14.jpg 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/12\/2-14-300x219.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\uff08a\uff09HPLC\u8272\u8c31\u56fe\u548c\uff08b\uff09\u572837\u00b0C\u4e0b\u4e0eMMP-2\uff082.5 \u03bcg\/mL\uff09\u5b75\u80b2\u540ePGGP\u7684\u964d\u89e3\u7387\u3002\uff08c\uff09\u7531DLS\u786e\u5b9a\u7684EAPV\u548cPV\u7684\u6c34\u52a8\u529b\u7c92\u5f84\u5206\u5e03\u3002\uff08d\uff09EAPV\u548cPV\u7684\u7d2b\u5916-\u53ef\u89c1\u5149\u8c31\u3002\uff08e\uff09EAPV\u548cPV\u7684\u8367\u5149\u6027\u8d28\uff1b\u63d2\u56fe\u663e\u793aPBS\uff08\u4e0a\u56fe\uff09\u6216SDS\uff08\u4e0b\u56fe\uff09\u4e2dEAPV\u7684NIR\u8367\u5149\u6210\u50cf\u3002\uff08f\uff09\u5206\u522b\u4e0e2.5 \u03bcg\/mL MMP-2\u5b75\u80b20\u30014\u548c24 h\u540e\uff0cEAPV\u7684\u4ee3\u8868\u6027TEM\u56fe\u50cf\uff08\u6bd4\u4f8b\u5c3a\u4e3a100 nm\uff09\u3002\uff08g\uff09EAPV\u7684\u591a\u5206\u6563\u6027\u6307\u6570\uff08PDI\uff09\u548c\uff08h\uff09\u6d41\u4f53\u52a8\u529b\u5b66\u76f4\u5f84\u7684\u53d8\u5316\u4e0e\u5b75\u80b2\u65f6\u95f4\u548cMMP-2\u6d53\u5ea6\u7684\u5173\u7cfb\u3002<\/p>\n<p><strong>\u56fe\u4e09\u3001\u4f53\u5916<\/strong><strong>EAPV<\/strong><strong>\u7684\u7ec6\u80de\u5185\u6444\u53d6\u548c\u5149\u6d3b\u6027<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-192076\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/12\/3-14.jpg\" alt=\"\" width=\"600\" height=\"555\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/12\/3-14.jpg 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/12\/3-14-300x278.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\u5728PPa\u6d53\u5ea6\u4e3a2.0 \u03bcM\u7684\u6761\u4ef6\u4e0b\u7528\uff08a\uff09CLSM\u548c\uff08b\uff09\u4f53\u5916\u6d41\u5f0f\u7ec6\u80de\u672f\u5206\u6790CT26\u7ec6\u80de\u4e2dEAPV\u7684\u7ec6\u80de\u5185\u6444\u53d6\u3002\uff08c\uff09CLSM\u5206\u6790CT26\u7ec6\u80deMCS\u4e2d\u7684EAPV\u548cPV\u5206\u5e03\u3002\uff08d\uff09\u6cbf\u7bad\u5934\u65b9\u5411\u7684CT26\u7ec6\u80deMCS\u4e2dEAPV\u548cPV\u7684\u8367\u5149\u5f3a\u5ea6\u5206\u5e03\u56fe\u548c\uff08e\uff092.5-D\u70ed\u56fe\u3002\uff08f\uff09\u6d41\u5f0f\u7ec6\u80de\u672f\u5206\u6790CT26\u7ec6\u80de\u4e2dEAPV\u4ea7\u751f\u80de\u5185ROS\u3002\uff08g\uff09\u5c06CT26\u7ec6\u80de\u4e0eNLG-919\uff0cNPC\uff0cp-lysoPC\u6216EAPV\u5b75\u80b248\u5c0f\u65f6\u540e\u7684\u7ec6\u80de\u6d3b\u529b\u3002\uff08h\uff09EAPV\u5728\u4f53\u5916CT26\u7ec6\u80de\u4e2d\u7684\u5149\u6bd2\u6027\u3002\uff08i\uff09PDT\u89e6\u53d1\u7684CRT\u66b4\u9732\u548c\uff08j\uff09\u4f53\u5916CT26\u7ec6\u80de\u7684HMGB1\u5916\u6392\u3002\uff08k\uff09\u4f53\u5916DC\u6210\u719f\u6d4b\u5b9a\u7684\u793a\u610f\u56fe\u3002\uff08l\uff09EAPV\u8bf1\u5bfc\u7684DC\u4f53\u5916\u6210\u719f\u3002<\/p>\n<p><strong>\u56fe\u56db\u3001<\/strong><strong>\u4f53\u5185\u524d\u836f\u56ca\u6ce1\u7684\u751f\u7269\u5206\u5e03\u548c\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u5f81<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-192077\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/12\/4-14.jpg\" alt=\"\" width=\"600\" height=\"464\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/12\/4-14.jpg 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/12\/4-14-300x232.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\uff08a\uff09\u9759\u8109\u6ce8\u5c04EAPV\u548c\u6e38\u79bbNLG919\u540e\uff0cBalb\/c\u5c0f\u9f20\u8840\u6d46NLG919\u7684\u6d53\u5ea6-\u65f6\u95f4\u66f2\u7ebf\u3002\uff08b\uff09CT26\u8377\u7624\u5c0f\u9f20\u4f53\u5185EAPV\u548cPV\u5206\u5e03\u7684IVIS\u56fe\u50cf\u3002\uff08c\uff09\u6ce8\u5c04\u540e24\u5c0f\u65f6\u68c0\u67e5\u7684\u80bf\u7624\u90e8\u4f4d\u7684\u6807\u51c6\u5316\u8367\u5149\u5f3a\u5ea6\u3002\uff08d\uff09\u6ce8\u5c04\u540e24\u5c0f\u65f6\u68c0\u67e5\u7684\u79bb\u4f53\u8377\u7624\u5c0f\u9f20\u4e3b\u8981\u5668\u5b98\u4e2dEAPV\u548cPV\u5206\u5e03\u7684IVIS\u56fe\u50cf\u3002\uff08e\uff09\u4e3b\u8981\u5668\u5b98\u7684\u6807\u51c6\u5316\u8367\u5149\u5f3a\u5ea6\u3002\uff08f\uff09\u6ce8\u5c04\u540e4 h\u68c0\u67e5CT26\u80bf\u7624\u5207\u7247\u4e2dEAPV\u5206\u5e03\u7684CLSM\u56fe\u50cf\u3002<\/p>\n<p><strong>\u56fe\u4e94\u3001\u4f53\u5185\u6297\u80bf\u7624\u4f5c\u7528\u548c\u514d\u75ab\u5b66\u6307\u6807\u5206\u6790<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-192078\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/12\/5-11.jpg\" alt=\"\" width=\"600\" height=\"716\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/12\/5-11.jpg 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/12\/5-11-251x300.jpg 251w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\uff08a\uff09EAPV\u6cbb\u7597\u7b56\u7565\u7684\u793a\u610f\u56fe\u3002\uff08b\uff094T1\u548c\uff08c\uff09CT26\u80bf\u7624\u6a21\u578b\u7684\u80bf\u7624\u4f53\u79ef\u53d8\u5316\u3002\uff08d\uff094T1\u8377\u7624\u5c0f\u9f20\u548c\uff08e\uff09CT26\u8377\u7624\u5c0f\u9f20\u7684\u751f\u5b58\u66f2\u7ebf\u3002\uff08f\uff09\u4f53\u5185CT26\u80bf\u7624\u8868\u9762CRT\u8868\u8fbe\u7684\u514d\u75ab\u8367\u5149\u548c\uff08g\uff09HMGB1\u5916\u6392\u5728CT26\u80bf\u7624\u4e2d\u7684\u514d\u75ab\u8367\u5149\u3002\uff08h\uff09\u80bf\u7624\u5f15\u6d41\u6dcb\u5df4\u7ed3\u7684\u7167\u7247\uff0c\u4ee5\u53ca\uff08i\uff09\u5728\u80bf\u7624\u5f15\u6d41\u6dcb\u5df4\u7ed3\u4e2d\u7684\u6210\u719f\u7684DC\u7684\u6bd4\u7387\u3002\uff08j\uff09\u80bf\u7624\u7ec4\u7ec7\u4e2d\u80bf\u7624\u5185\u6d78\u6da6T\u6dcb\u5df4\u7ec6\u80de\u7684\u6bd4\u7387\u3002\uff08k\uff09\u6cbb\u7597\u540e3\u5929\u68c0\u67e5\u7684IFN-\u03b3<sup>+<\/sup> CTLs \u7684\u4ee3\u8868\u6027\u6d41\u5f0f\u7ec6\u80de\u66f2\u7ebf\u3002<\/p>\n<p><strong>\u56fe\u516d\u3001<\/strong><strong>EAPV<\/strong><strong>\u8bf1\u5bfc\u7684\u4f53\u5185<\/strong><strong>ICD<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-192079\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/12\/6-7.jpg\" alt=\"\" width=\"600\" height=\"730\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/12\/6-7.jpg 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2019\/12\/6-7-247x300.jpg 247w\" sizes=\"(max-width: 600px) 100vw, 600px\" 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href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.nanolett.9b04012\">Sheddable Prodrug Vesicles Combating Adaptive Immune Resistance for Improved Photodynamic Immunotherapy of Cancer<\/a> (<em>Nano Lett.,<\/em> <strong>2019<\/strong>, DOI: 10.1021\/acs.nanolett.9b04012)<\/p>\n<p><strong>\u674e\u4e9a\u5e73\u7814\u7a76\u5458<\/strong>\uff1a\u836f\u5242\u5b66\u535a\u58eb\uff0c\u7814\u7a76\u5458\uff0c\u56fd\u5bb6\u57fa\u91d1\u59d4\u521b\u65b0\u7fa4\u4f53\u5b66\u672f\u5e26\u5934\u4eba\uff0c\u6770\u51fa\u9752\u5e74\u57fa\u91d1\u83b7\u5f97\u8005\uff0c973\u9996\u5e2d\u79d1\u5b66\u5bb6\uff0c\u56fd\u5bb6\u4e07\u4eba\u8ba1\u5212\u3001\u4e2d\u79d1\u9662\u767e\u4eba\u8ba1\u5212\u4e13\u5bb6\uff0c\u73b0\u4efb\u4e2d\u79d1\u9662\u4e0a\u6d77\u836f\u7269\u7814\u7a76\u6240\u836f\u7269\u5236\u5242\u7814\u7a76\u4e2d\u5fc3\u4e3b\u4efb\u3002\u7814\u7a76\u65b9\u5411\u5305\u62ec\u7eb3\u7c73\u8f7d\u836f\u7cfb\u7edf\u6297\u80bf\u7624\u8f6c\u79fb\u53ca\u514b\u670d\u80bf\u7624\u8010\u836f\uff0c\u6838\u9178\u836f\u7269\u975e\u75c5\u6bd2\u8f7d\u4f53\u53ca\u5176\u5bfc\u5165\u7cfb\u7edf\uff0c\u4ee5\u53ca\u521b\u65b0\u836f\u7269\u4e0e\u9ad8\u7aef\u5236\u5242\u7684\u7814\u7a76\u5f00\u53d1\u3002\u5728Nat Med\u3001Chem Soc\u3001Adv Mater\u3001Sci Immunol\u3001Nat Commun\u7b49\u56fd\u9645\u91cd\u8981\u5b66\u672f\u671f\u520a\u4e0a\u53d1\u8868\u9ad8\u8d28\u91cf\u8bba\u6587200\u4f59\u7bc7\uff08\u5176\u4e2dIF\uff1e10\u7684\u8bba\u658780\u4f59\u7bc7\uff09\u3002\u5df2\u83b7\u5f97\u65b0\u836f\u8bc1\u4e669\u672c, \u4e34\u5e8a\u6279\u4ef613\u4ef6\uff08\u521b\u65b0\u836f\u7269\u5236\u5242\u4e34\u5e8a\u6279\u4ef610\u4ef6\uff09; \u7533\u8bf7\u4e13\u522982\u4ef6(\u6388\u674342\u4ef6)\u3002<\/p>\n<p><strong>\u4e8e\u6d77\u519b\u7814\u7a76\u5458<\/strong>\uff1a\u4e8e\u6d77\u519b\u7814\u7a76\u5458\u957f\u671f\u81f4\u529b\u4e8e\u65b0\u578b\u7eb3\u7c73\u8f7d\u836f\u7cfb\u7edf\u7814\u7a76\u5e76\u53d6\u5f97\u4e86\u7a81\u51fa\u6210\u7ee9\uff1a1\uff09\u6784\u5efa\u4e86\u7cfb\u5217\u65b0\u578b\u7eb3\u7c73\u8f7d\u836f\u7cfb\u7edf\uff0c\u6fc0\u6d3b\u80bf\u7624\u514d\u75ab\u6548\u5e94\u5e76\u9006\u8f6c\u80bf\u7624\u514d\u75ab\u6291\u5236\u5fae\u73af\u5883\uff0c\u6709\u6548\u6297\u80bf\u7624\u8f6c\u79fb\u548c\u590d\u53d1\uff1b2\uff09\u6784\u5efa\u4e86\u7cfb\u5217\u5feb\u901f\u54cd\u5e94\u7eb3\u7c73\u8f7d\u836f\u7cfb\u7edf\u514b\u670d\u80bf\u7624\u7ec4\u7ec7\u548c\u7ec6\u80de\u751f\u7406\u5c4f\u969c\uff0c\u63d0\u9ad8\u836f\u7269\u8f6c\u8fd0\u6548\u7387\uff0c\u663e\u8457\u6539\u5584\u80bf\u7624\u5316\u7597\u548cRNA\u5e72\u6270\u6cbb\u7597\u6548\u679c\uff1b3\uff09\u4ece\u5206\u5b50\u3001\u7ec6\u80de\u548c\u7ec4\u7ec7\u5c42\u9762\u63ed\u793a\u4e86\u4e0a\u8ff0\u7eb3\u7c73\u8f7d\u836f\u7cfb\u7edf\u6297\u80bf\u7624\u8010\u836f\u548c\u8f6c\u79fb\u7684\u5173\u952e\u4f5c\u7528\u673a\u5236\u3002\u66fe\u83b7\u5f97\u79d1\u6280\u90e8\u4e2d\u9752\u5e74\u79d1\u6280\u521b\u65b0\u9886\u519b\u4eba\u624d\u548c\u4e2d\u56fd\u836f\u5b66\u4f1a-\u8d5b\u8bfa\u83f2\u9752\u5e74\u751f\u7269\u836f\u7269\u5956\u7b49\u79d1\u7814\u5956\u52b1\u53ca\u8363\u8a89\u3002\u4e3b\u6301\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u201c\u4f18\u79c0\u9752\u5e74\u57fa\u91d1\u201d\u3001\u9762\u4e0a\u9879\u76ee\u548c\u79d1\u6280\u90e8\u201c973\u201d\u8bfe\u9898\u7b49\u591a\u9879\u79d1\u7814\u9879\u76ee\u3002<\/p>\n<p>\u672c\u6587\u7531\u5927\u5175\u54e5\u4f9b\u7a3f\u3002<\/p>\n<p>\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1\uff1a<a href=\"mailto:tougao@cailiaoren.com\">tougao@cailiaoren.com<\/a><\/p>\n<p>\u6295\u7a3f\u4ee5\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1acailiaokefu<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u7814\u7a76\u80cc\u666f\u3011 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