{"id":193532,"date":"2020-01-08T06:07:00","date_gmt":"2020-01-07T22:07:00","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=193532"},"modified":"2020-01-07T22:07:14","modified_gmt":"2020-01-07T14:07:14","slug":"%e5%8e%a6%e5%a4%a7%e9%ab%98%e9%94%a6%e8%b1%aa%e5%9b%a2%e9%98%9fnano-lett-%ef%bc%9a%e7%ba%a7%e8%81%94%e7%9a%84%e5%a4%9a%e5%93%8d%e5%ba%94%e8%87%aa%e7%bb%84%e8%a3%8519f-mri%e7%ba%b3%e7%b1%b3%e6%8e%a2","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=193532","title":{"rendered":"\u53a6\u5927\u9ad8\u9526\u8c6a\u56e2\u961fNano Lett.\uff1a\u7ea7\u8054\u7684\u591a\u54cd\u5e94\u81ea\u7ec4\u88c519F MRI\u7eb3\u7c73\u63a2\u9488\u901a\u8fc7\u6fc0\u6d3b\/\u6269\u589e\u4e24\u4e2a\u9636\u6bb5\u5bf9\u8fdb\u884c\u80bf\u7624\u7cbe\u786e\u7684\u68c0\u6d4b\u548c\u6210\u50cf"},"content":{"rendered":"

\u3010\u80cc\u666f\u4ecb\u7ecd\u3011<\/strong><\/p>\n

\u76f8\u5bf9\u6b63\u5e38\u751f\u7406\u73af\u5883\u800c\u8a00\uff0c\u75c5\u7406\u72b6\u6001\u5e38\u8868\u73b0\u4e3a\u9178\u4e2d\u6bd2\u3001\u7f3a\u6c27\u3001\u67d0\u4e9b\u86cb\u767d\u8fc7\u8868\u8fbe\u3001\u6c27\u5316\u8fd8\u539f\u5931\u8861\u7b49\u73b0\u8c61\u3002\u76ee\u524d\uff0c\u5df2\u5e7f\u6cdb\u7684\u63a2\u7d22\u4e86\u54cd\u5e94\u4e8e\u751f\u7269\u76f8\u5173\u523a\u6fc0\u7684\u53ef\u6fc0\u6d3b\u63a2\u9488\uff0c\u5e76\u5c06\u5176\u7528\u4e8e\u6210\u50cf\u548c\u836f\u7269\u9012\u9001\uff0c\u4ee5\u901a\u8fc7\u75be\u75c5\u90e8\u4f4d\u7279\u5f02\u6027\u7684\u9012\u9001\u3001\u6fc0\u6d3b\u548c\u63a7\u5236\u91ca\u653e\u6765\u63d0\u9ad8\u8bca\u65ad\u548c\u6cbb\u7597\u6548\u679c\u3002\u4f8b\u5982\uff0c\u8c37\u80f1\u7518\u80bd\uff08GSH\uff09\u5728\u8bb8\u591a\u751f\u7406\u8fc7\u7a0b\u4e2d\u8d77\u7740\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\u3002\u9274\u4e8e\u764c\u7ec6\u80de\u4e2dGSH\u7684\u6d53\u5ea6\u662f\u6b63\u5e38\u7ec6\u80de\u76844\u500d\u4ee5\u4e0a\uff0c\u56e0\u800c\u5229\u7528\u7279\u5f02\u6027\u54cd\u5e94GSH\u8367\u5149\u63a2\u9488\u5bf9\u80bf\u7624\u6210\u50cf\u53ca\u5f15\u5bfc\u80bf\u7624\u6cbb\u7597\u3002\u7136\u800c\uff0c\u7531\u4e8e\u8367\u5149\u63a2\u9488\u7684\u7ec4\u7ec7\u7a7f\u900f\u6027\u8f83\u4f4e\uff0c\u6781\u5927\u7684\u9650\u5236\u4e86\u5176\u5e94\u7528\u3002\u56e0\u6b64\uff0c\u4e9f\u9700\u5f00\u53d1\u80fd\u591f\u8fdb\u884c\u6df1\u90e8\u7ec4\u7ec7\u53ef\u89c6\u5316\u7684\u66ff\u4ee3\u8367\u5149\u63a2\u9488\u3002<\/p>\n

\u8fd1\u4e9b\u5e74\u6765\uff0c\u7531\u4e8e\u78c1\u5171\u632f\u6210\u50cf\uff08MRI\uff09\u5177\u6709\u65e0\u521b\u6027\u3001\u7a7a\u95f4\u5206\u8fa8\u7387\u9ad8\u548c\u7ec4\u7ec7\u7a7f\u900f\u6027\u5f3a\u7b49\u4f18\u70b9\u800c\u6210\u4e3a\u5e94\u7528\u6700\u5e7f\u6cdb\u7684\u8bca\u65ad\u6280\u672f\u4e4b\u4e00\u3002\u7136\u800c\uff0c\u7531\u4e8e\u6c34\u5206\u5b50\u4e2d\u7684\u56fa\u67091<\/sup>H\u4fe1\u53f7\uff0c\u4f7f\u5f97\u4f20\u7edf1<\/sup>H MRI\u7684\u523a\u6fc0\u54cd\u5e94\u63a2\u9488\u53d7\u5230\u5bf9\u6bd4\u5ea6\u4f4e\u548c\u80cc\u666f\u5e72\u6270\u7684\u5f71\u54cd\u3002\u7531\u4e8e19<\/sup>F MRI\u5177\u6709\u9ad8\u7075\u654f\u5ea6\uff081<\/sup>H\u768483\uff05\uff09\uff0c\u5bbd\u6cdb\u7684\u5316\u5b66\u4f4d\u79fb\uff08>350 ppm\uff09\u548c\u53ef\u5ffd\u7565\u7684\u80cc\u666f\uff08\u4eba\u4f53\u4e2d<10-6<\/sup> M\uff09\u7b49\u4f18\u70b9\uff0c\u4f7f\u5176\u6709\u671b\u5f25\u8865\u4f20\u7edf1<\/sup>H MRI\u7684\u4e0d\u8db3\u3002\u867d\u7136\u73b0\u5728\u5df2\u62a5\u9053\u4e86\u591a\u79cd\u901a\u8fc7\u6539\u53d8\u73af\u5883\uff08\u751f\u7269\u5206\u5b50\u3001\u5316\u5b66\u6761\u4ef6\u548c\u5916\u90e8\u7269\u7406\u6761\u4ef6\uff09\u6765\u667a\u80fd\u6027\u7684\u63a7\u5236\u54cd\u5e9419<\/sup>F MRI\uff0c\u4f46\u662f\u5f88\u5c11\u62a5\u9053\u5173\u4e8e19<\/sup>F MRI\u5bf9\u591a\u79cd\u523a\u6fc0\u53cd\u5e94\u7684\u3002\u56e0\u6b64\uff0c\u5229\u7528\u5177\u6709\u591a\u4e2a\u7ea7\u8054\u4fe1\u53f7\u6fc0\u6d3b\/\u6269\u589e\u7684\u523a\u6fc0\u54cd\u5e94\u768419<\/sup>F MRI\u53ef\u80fd\u662f\u4e00\u79cd\u66f4\u597d\u7684\u7b56\u7565\uff0c\u539f\u56e0\u5982\u4e0b\uff1a\uff081\uff09\u7ea7\u8054\u7684\u4fe1\u53f7\u6fc0\u6d3b\/\u6269\u589e\u6d89\u53ca\u591a\u4e2a\u523a\u6fc0\u54cd\u5e94\u8fc7\u7a0b\uff0c\u5c06\u663e\u7740\u589e\u5f3a\u63a2\u9488\u7684\u7279\u5f02\u6027\uff1b\uff082\uff09\u7ea7\u8054\u7684\u4fe1\u53f7\u6fc0\u6d3b\/\u6269\u589e\u7531\u4e8e\u500d\u589e\u6548\u5e94\u53ef\u6781\u5927\u589e\u5f3a\u4fe1\u53f7\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u57fa\u4e8e\u6b64\uff0c\u53a6\u95e8\u5927\u5b66\u7684\u9ad8\u9526\u8c6a\u6559\u6388\uff08\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u56e2\u961f\u62a5\u9053\u4e86\u4e00\u79cd\u7ea7\u8054\u7684\u591a\u54cd\u5e94\u7684\u81ea\u7ec4\u88c5\u7eb3\u7c73\u63a2\u9488\uff0c\u5176\u80fd\u591f\u8fde\u7eed\u6c27\u5316\u8fd8\u539f\u89e6\u53d1\u548c\u8fd1\u7ea2\u5916\uff08NIR\uff09\u8f90\u7167\u8bf1\u5bfc19<\/sup>F MR\u4fe1\u53f7\u6fc0\u6d3b\/\u6269\u589e\uff0c\u4ee5\u8fdb\u884c\u4f20\u611f\u548c\u6210\u50cf\u3002\u5177\u4f53\u800c\u8a00\uff0c\u8bbe\u8ba1\u5e76\u5408\u6210\u4e86\u4e00\u79cd\u57fa\u4e8e\u4e24\u4eb2\u6027\u6c27\u5316\u8fd8\u539f\u53cd\u5e94\u7684\u542b19<\/sup>F\u7684\u805a\u5408\u7269\u548c\u5438\u6536NIR\u7684\u5432\u54da\u83c1\u7eff\uff08ICG\uff09\u5206\u5b50\u81ea\u7ec4\u88c5\u7684\u7ea7\u8054\u7684\u591a\u54cd\u5e94\u6027\u7684\u542b19<\/sup>F\u7eb3\u7c73\u63a2\u9488\u3002\u5229\u7528\u8be5\u7eb3\u7c73\u63a2\u9488\u53ef\u4ee5\u5728\u8fd8\u539f\u6027\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u5b9e\u73b019F\u4fe1\u53f7\u7684\u6fc0\u6d3b\uff0c\u5e76\u901a\u8fc7\u5149\u70ed\u8fc7\u7a0b\u5b9e\u73b0\u968f\u540e\u7684\u4fe1\u53f7\u653e\u5927\u3002\u901a\u8fc7\u5728\u4f53\u5916\u548c\u4f53\u5185\u768419<\/sup>F NMR\u548cMRI\u5b9e\u9a8c\uff0c\u8bc1\u5b9e\u4e8619<\/sup>F\u4fe1\u53f7\u80fd\u591f\u9010\u6b65\u7684\u5206\u9636\u6bb5\u6fc0\u6d3b\/\u6269\u589e\u3002\u5229\u7528\u5177\u6709\u80fd\u591f\u7ea7\u805419<\/sup>F\u4fe1\u53f7\u6fc0\u6d3b\/\u6269\u589e\u548c\u5149\u70ed\u6548\u5e94\u53d1\u6325\u4f5c\u7528\u7684\u591a\u54cd\u5e9419<\/sup>F\u7eb3\u7c73\u63a2\u9488\u53ef\u4ee5\u5bf9\u80bf\u7624\u8fdb\u884c\u7cbe\u786e\u7684\u611f\u6d4b\u548c\u6210\u50cf\u3002\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a\u201cCascaded Multiresponsive Self-Assembled 19<\/sup>F MRI Nanoprobes with Redox-Triggered Activation and NIR-Induced Amplification\u201d<\/strong>\u53d1\u5e03\u5728\u8457\u540d\u671f\u520aNano Lett.<\/strong>\u4e0a\u3002
\n \"\"
\n \u3010\u56fe\u6587\u89e3\u8bfb\u3011<\/strong><\/p>\n

\u56fe\u4e00\u30011-ICG\u7eb3\u7c73\u63a2\u9488\u7684\u793a\u610f\u56fe\u548c\u8868\u5f81<\/strong>
\n \"\"\uff08a\uff09\u7ea7\u805419<\/sup>F\u4fe1\u53f7\u6fc0\u6d3b\/\u6269\u589e\u7684\u81ea\u7ec4\u88c5\u591a\u54cd\u5e94\u768419<\/sup>F\u7eb3\u7c73\u63a2\u9488\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08b-c\uff09\u81ea\u7ec4\u88c5\u76841-ICG NPs\u7684TEM\u56fe\u50cf\u548c\u901a\u8fc7DLS\u7684\u7c92\u5f84\u5206\u6790\uff1b<\/p>\n

\uff08d\uff09\u6c34\u4e2d\u6e38\u79bbICG\u548c\u81ea\u7ec4\u88c5\u76841-ICG NPs\u7684UV-vis\uff08\u9ed1\u7ebf\uff09\u548c\u8367\u5149\u53d1\u5c04\uff08\u7ea2\u7ebf\uff09\u5149\u8c31\u3002<\/p>\n

\u56fe\u4e8c\u3001\u81ea\u7ec4\u88c5\u76841-ICG\u7eb3\u7c73\u63a2\u9488\u7684\u7ea7\u8054\u4fe1\u53f7\u6fc0\u6d3b\/\u6269\u589e\u548c\u7279\u5f02\u6027\u8bc4\u4f30<\/strong>
\n \"\"\uff08a\uff091-ICG NPs\u5728500 \u03bcL10\uff05 D2<\/sub>O\/H2<\/sub>O\u4e2d\u4e0eGSH\u4e00\u8d77\u5b75\u80b2\u6307\u5b9a\u65f6\u95f4\u768419<\/sup>F NMR\u5149\u8c31\uff1b<\/p>\n

\uff08b\uff09\u90e8\u5206a\u4e2d19<\/sup>F NMR\u5149\u8c31\u7684\u4fe1\u566a\u6bd4\uff08SNR\uff09\uff1b<\/p>\n

\uff08c\uff09\u5728808 nm\u6fc0\u5149\u7167\u5c04\u4e0b\uff0c500 \u03bcL10\uff05 D2<\/sub>O\/H2<\/sub>O\u4e2d\u76841-ICG NPs\u768419<\/sup>F NMR\u5149\u8c31\uff1b<\/p>\n

\uff08d\uff09c\u90e8\u5206\u4e2d19<\/sup>F NMR\u5149\u8c31\u7684SNR\uff1b<\/p>\n

\uff08e\uff09\u5728\u4e0d\u540c\u529f\u7387\u5f3a\u5ea6\u4e0b\uff0c\u76f4\u63a5\u7528808 nm\u6fc0\u5149\u7167\u5c041-ICG NPs\u768419<\/sup>F NMR\u5149\u8c31\uff1b<\/p>\n

\uff08f\uff09\u4e0eGSH\u5b75\u80b22 h\u5e76\u7528808 nm\u6fc0\u5149\u7167\u5c04Ctrl 1-ICG NPs\u768419<\/sup>F NMR\u5149\u8c31\uff1b<\/p>\n

\uff08g\uff09\u4e0eGSH\u5b75\u80b22 h\u5e76\u7528808 nm\u6fc0\u5149\u7167\u5c0410 min\u65f6\uff0c1-ICG NPs\u768419<\/sup>F NMR\u5149\u8c31\uff1b<\/p>\n

\uff08h\uff09g\u90e8\u5206\u4e2d19<\/sup>F NMR\u5149\u8c31\u7684SNR\uff1b<\/p>\n

\uff08i\uff09\u4e0eGSH\u5b75\u80b22 h\u540e\uff0c\u7528\u4e0d\u540c\u529f\u7387\u7684808 nm\u6fc0\u5149\u7167\u5c041-ICG NPs\u6c34\u6eb6\u6db2\u7684\u6e29\u5ea6\u66f2\u7ebf\u3002<\/p>\n

\u56fe\u4e09\u3001\u7ea7\u8054\u7684\u591a\u54cd\u5e941-ICG\u7eb3\u7c73\u63a2\u9488\u7684\u5f62\u8c8c\u53d8\u5316<\/strong>
\n \"\"\uff08a\uff09\u752820 mM GSH\u5904\u74062 h\u540e\uff0c1-ICG NPs\u7684TEM\u56fe\u50cf\uff1b<\/p>\n

\uff08b\uff09a\u4e2d1-ICG NPs\u7684\u7c92\u5f84\u5206\u5e03\uff1b<\/p>\n

\uff08c\uff09\u752820 mM GSH\u5b75\u80b22 h\uff0c\u5e76\u7528808 nm\u6fc0\u5149\u4ee51.5 W\/cm2<\/sup>\u8f90\u5c0410 min\u540e\uff0c 1-ICG NPs\u7684TEM\u56fe\u50cf\uff1b<\/p>\n

\uff08d\uff09\u76f4\u63a5\u7528808 nm\u6fc0\u5149\u4ee5\u529f\u7387\u4e3a1.5 \/ cm2<\/sup>\u7167\u5c0410 min\u540e\uff0c1-ICG NPs\u7684TEM\u56fe\u50cf\uff1b<\/p>\n

\uff08e\uff09d\u4e2d1-ICG NPs\u7684\u7c92\u5f84\u5206\u5e03\uff1b<\/p>\n

\uff08f\uff09\u76f4\u63a5\u7528808 nm\u6fc0\u5149\u7167\u5c04\u540e\uff0c1-ICG NPs\u7684\u7ed3\u6784\u53d8\u5316\u3002<\/p>\n

\u56fe\u56db\u300119<\/sup>F\u201c\u70ed\u70b9\u201d\u7ec6\u80de\u5185\u6a21\u62df\u6210\u50cf<\/strong>
\n \"\"\uff08a\uff09\u7528\u81ea\u7ec4\u88c5\u76841-ICG NPs\u5904\u7406HepG2\u7ec6\u80de\uff0c\u5728808 nm\u6fc0\u5149\u8f90\u7167\u540e\uff0c\u8fdb\u884c19<\/sup>F NMR\/MRI\u7684\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08b\uff09\u7528\u81ea\u7ec4\u88c5\u76841-ICG NPs\u5904\u740624 h\u540e\uff0c\u57281.5 W\/cm2<\/sup>\u7684808 nm\u6fc0\u5149\u7167\u5c04\u5904\u740610 min\u540e\uff0cHepG2\u7ec6\u80de\u768419<\/sup>F NMR\u5149\u8c31\uff1b<\/p>\n

\uff08c\uff09\u4e0e1-ICG NPs\u5b75\u80b224 h\u540e\uff0c\u7528808 nm\u6fc0\u5149\u4ee51.5 W\/cm2<\/sup>\u7167\u5c04HepG2\u7ec6\u80de\u7684\u6e29\u5ea6\u66f2\u7ebf\uff1b<\/p>\n

\uff08d\uff09\u91c7\u7528\u4e0d\u540c\u5904\u7406\u65b9\u6cd5\u540e\uff0cHepG2\u7ec6\u80de\u88c2\u89e3\u7269\u76841<\/sup>H MRI\u548c\u76f8\u5e94\u768419<\/sup>F MRI\u6a21\u62df\u56fe\u50cf\u3002<\/p>\n

\u56fe\u4e94\u3001\u5177\u6709\u9010\u6b65\u5206\u9636\u6bb5\u6fc0\u6d3b\/\u6269\u589e\u529f\u80fd\u768419<\/sup>F MRI\u7528\u4e8e\u68c0\u6d4b\u80bf\u7624\u4e2d\u7684\u5916\u6e90\u6027GSH<\/strong>
\n \"\"\uff08a\uff09\u5bf9HepG2\u8377\u7624\u5c0f\u9f20\u6ce8\u5165GSH\u548c\u81ea\u7ec4\u88c5\u76841-ICG NPs\uff0c\u518d\u5229\u7528808 nm\u6fc0\u5149\u7167\u5c04\u540e\u7684\u4f53\u5185\u5b9e\u9a8c\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08b\uff09\u76ae\u4e0b\u6ce8\u5c04GSH\u548c1-ICG NPs\uff08\u4e0a\u56fe\uff09\uff0c\u5728808 nm\u6fc0\u5149\u4ee51.5 W\/cm2<\/sup>\u7167\u5c04\u5904\u74066 min\uff08\u4e0b\u56fe\uff09\u540e\uff0c\u5bf9HepG2\u8377\u7624\u5c0f\u9f20\u8fdb\u884c1<\/sup>H\/19<\/sup>F MRI\u3002<\/p>\n

\u56fe\u516d\u3001\u901a\u8fc7\u4f53\u518519<\/sup>F MRS\/MRI\u6210\u50cf\uff0c\u5229\u75281-ICG NPs\u68c0\u6d4b\u80bf\u7624\u4e2d\u7684\u5185\u6e90\u6027GSH<\/strong>
\n \"\"\uff08a\uff09\u5229\u7528\u81ea\u7ec4\u88c5\u76841-ICG NPs\u5904\u7406\u8377HepG2\u8377\u7624\u5c0f\u9f20\uff0c\u5e76\u7528808 nm\u6fc0\u5149\u7167\u5c04\u83b7\u5f9719<\/sup>F MRS\/MRI\u7684\u4f53\u5185\u5b9e\u9a8c\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08b-c\uff09\u5728\u80bf\u7624\u5185\u6ce8\u5c041-ICG NPs 0 h\u30018 h\u540e\uff0c\u5bf9HepG2\u8377\u7624\u5c0f\u9f20\u8fdb\u884c\u7684\u5b9e\u65f619<\/sup>F MRS\uff1b<\/p>\n

\uff08d\uff09\u6ce8\u5c041-ICG NPs 8 h\u540e\uff0c\u7528808 nm\u6fc0\u5149\u7167\u5c046 min\u540e\uff0c\u5bf9HepG2\u8377\u7624\u5c0f\u9f20\u76841<\/sup>H\/19<\/sup>F MRI\uff1b<\/p>\n

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\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

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\u6587\u732e\u94fe\u63a5\uff1aCascaded Multiresponsive Self-Assembled 19F MRI Nanoprobes with Redox-Triggered Activation and NIR-Induced Amplification<\/a><\/strong>\uff08Nano Lett.<\/em>, 2019<\/strong>, DOI: 10.1021\/acs.nanolett.9b04016\uff09<\/p>\n

\u901a\u8baf\u4f5c\u8005\u7b80\u4ecb<\/strong><\/p>\n

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\u672c\u6587\u7531CQR\u7f16\u8bd1<\/p>\n

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