{"id":195133,"date":"2020-01-29T06:46:07","date_gmt":"2020-01-28T22:46:07","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=195133"},"modified":"2020-01-28T19:46:34","modified_gmt":"2020-01-28T11:46:34","slug":"%e6%9c%80%e6%96%b0%e8%82%ba%e7%82%8e%e7%96%ab%e6%83%85%e7%9a%84%e6%9d%83%e5%a8%81%e8%a7%a3%e8%af%bb%e6%9d%a5%e4%ba%86%e5%8c%bb%e5%ad%a6%e9%a1%b6%e5%88%8a%e3%80%8anejm%e3%80%8b%e5%92%8c%e3%80%8alancet","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=195133","title":{"rendered":"\u6700\u65b0\u80ba\u708e\u75ab\u60c5\u7684\u6743\u5a01\u89e3\u8bfb\u6765\u4e86!\u533b\u5b66\u9876\u520a\u300aNEJM\u300b\u548c\u300aLANCET\u300b\u7eb7\u7eb7\u53d1\u8868\u6743\u5a01\u5206\u6790\uff01"},"content":{"rendered":"

\u5982\u4eca\uff0c\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u8086\u8650\uff0c\u5b85\u5728\u5bb6\u7684\u6211\u4eec\uff0c\u5ef6\u671f\u5f00\u5b66\u4e0a\u73ed\uff0c\u4e0d\u5982\u8ba9\u6211\u4eec\u4e00\u8d77\u6765\u770b\u770b\u533b\u5b66\u754c\u5bf9\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u7684\u6700\u65b0\u7814\u7a76\u60c5\u51b5\u3002<\/p>\n

1\u3001\u4e2d\u56fd\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u8bfe\u9898\u7ec4\u7684\u6731\u5a1c\u7b49\u4eba\u5728The New England Journal of Medicine (IF:70.67)\u4e0a\u53d1\u8868:\u00a0A Novel Coronavirus from Patients with Pneumonia in China, 2019 \uff082019\u5e74\u4e2d\u56fd\u80ba\u708e\u60a3\u8005\u4e2d\u7684\u4e00\u79cd\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\uff09\u3002<\/strong><\/p>\n

\u901a\u8fc7\u5bf9\u80ba\u708e\u60a3\u8005\u7684\u6837\u672c\u8fdb\u884c\u65e0\u504f\u5e8f\u6d4b\u5e8f\uff0c\u53d1\u73b0\u4e86\u4e00\u79cd\u4ee5\u524d\u4e0d\u4e3a\u4eba\u77e5\u7684\u6b21\u51a0\u72b6\u75c5\u6bd2\u3002\u4eba\u7c7b\u6c14\u9053\u4e0a\u76ae\u7ec6\u80de\u88ab\u7528\u6765\u5206\u79bb\u4e00\u79cd\u65b0\u7684\u51a0\u72b6\u75c5\u6bd2\uff0c\u547d\u540d\u4e3a2019-nCoV\uff0c\u5b83\u5f62\u6210\u4e86subgenus sarbecovirus\u7684\u53e6\u4e00\u4e2a\u5206\u652f\uff0c\u5373\u539f\u51a0\u72b6\u75c5\u6bd2\u4e9a\u79d1\u3002\u4e0eMERS-CoV\u548cSARS-CoV\u4e0d\u540c\uff0c2019-nCoV\u662f\u611f\u67d3\u4eba\u7c7b\u7684\u51a0\u72b6\u75c5\u6bd2\u5bb6\u65cf\u4e2d\u7684\u7b2c7\u4e2a\u6210\u5458\u3002\u6b63\u5728\u52a0\u5f3a\u76d1\u6d4b\u548c\u8fdb\u4e00\u6b65\u8c03\u67e5\u3002(\u56fd\u5bb6\u91cd\u70b9\u7814\u7a76\u5f00\u53d1\u9879\u76ee\u3001\u56fd\u5bb6\u4f20\u67d3\u75c5\u9632\u6cbb\u91cd\u70b9\u9879\u76ee\u8d44\u52a9)<\/p>\n

2\u3001\u56fd\u5bb6\u547c\u5438\u75be\u75c5\u4e34\u5e8a\u7814\u7a76\u4e2d\u5fc3\u547c\u5438\u5185\u79d1\u80ba\u79d1\u548c\u91cd\u75c7\u533b\u5b66\u79d1\u3001\u6b66\u6c49\u91d1\u94f6\u6ee9\u533b\u9662\u7b49\u5355\u4f4d\u7684\u9ec4\u671d\u6797\u7b49\u4eba\u5728LANCET(IF:59.10)\u4e0a\u53d1\u8868\uff1aClinical features of patients infected with 2019 novel coronavirus in Wuhan, China\uff08\u6b66\u6c49\u5e022019\u5e74\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u611f\u67d3\u8005\u7684\u4e34\u5e8a\u7279\u5f81\uff09\u3002<\/strong><\/p>\n

\u672c\u7814\u7a76\u8868\u660e2019-nCoV\u611f\u67d3\u5bfc\u81f4\u4e86\u7c7b\u4f3c\u4e8e\u4e25\u91cd\u6025\u6027\u547c\u5438\u7efc\u5408\u5f81\u51a0\u72b6\u75c5\u6bd2\u7684\u4e25\u91cd\u547c\u5438\u9053\u75be\u75c5\u7fa4\u96c6\uff0c\u5e76\u4e0eICU\u5165\u9662\u548c\u9ad8\u6b7b\u4ea1\u7387\u76f8\u5173\u3002\u622a\u81f32020\u5e741\u67082\u65e5\uff0c\u6b66\u6c49\u5e02\u5171\u670941\u4f8b\u4f4f\u9662\u60a3\u8005\u88ab\u5b9e\u9a8c\u5ba4\u786e\u8bca\u4e3a2019-nCoV\u611f\u67d3\uff0c\u5176\u4e2d20\u4f8b(49%)\u60a3\u8005\u5e74\u9f8425 ~ 49\u5c81\uff0c14\u4f8b(34%)\u60a3\u8005\u5e74\u9f8450 ~ 64\u5c81(\u56fe1A)\u3002\u60a3\u8005\u4e2d\u4f4d\u5e74\u9f8449.0\u5c81(IQR 41.0-58.0;\u88681)\u3002\u622a\u6b621\u67082\u65e5\uff0c\u6211\u4eec\u7684\u961f\u5217\u524d41\u4f8b\u60a3\u8005\u4e2d\uff0c\u6ca1\u6709\u513f\u7ae5\u6216\u9752\u5c11\u5e74\u611f\u67d3\u3002\u572841\u4f8b\u60a3\u8005\u4e2d\uff0c\u670913\u4f8b(32%)\u56e0\u9700\u8981\u9ad8\u6d41\u91cf\u9f3b\u63d2\u7ba1\u6216\u9ad8\u6c34\u5e73\u6c27\u652f\u6301\u63aa\u65bd\u6765\u7ea0\u6b63\u4f4e\u6c27\u8840\u75c7\u800c\u4f4f\u8fdbICU\u3002\u611f\u67d3\u60a3\u8005\u4ee5\u7537\u6027\u5c45\u591a(30\u4f8b[73%]);\u4e0d\u5230\u4e00\u534a\u7684\u4eba\u6709\u6f5c\u5728\u7684\u75be\u75c5(13\u4eba[32%])\uff0c\u5305\u62ec\u7cd6\u5c3f\u75c5(8\u4eba[20%])\u3001\u9ad8\u8840\u538b(6\u4eba[15%])\u548c\u5fc3\u8840\u7ba1\u75be\u75c5(6\u4eba[15%])\u3002<\/p>\n

\u60a3\u8005\u76f4\u63a5\u63a5\u89e6\u534e\u5357\u6d77\u9c9c\u5e02\u573a27\u4f8b(66%)(\u56fe1B)\u3002ICU\u62a4\u7406\u60a3\u8005(9\u4f8b[69%])\u4e0e\u975eICU\u62a4\u7406\u60a3\u8005(18\u4f8b[64%])\u7684\u5e02\u573a\u66b4\u9732\u76f8\u4f3c\u3002\u7b2c\u4e00\u4f8b\u786e\u8bca\u60a3\u8005\u7684\u75c7\u72b6\u51fa\u73b0\u65e5\u671f\u4e3a2019\u5e7412\u67081\u65e5\u3002\u4ed6\u7684\u5bb6\u4eba\u6ca1\u6709\u51fa\u73b0\u53d1\u70e7\u6216\u4efb\u4f55\u547c\u5438\u9053\u75c7\u72b6\u3002\u5728\u7b2c\u4e00\u4e2a\u75c5\u4eba\u548c\u540e\u6765\u7684\u75c5\u4f8b\u4e4b\u95f4\u6ca1\u6709\u53d1\u73b0\u6d41\u884c\u75c5\u5b66\u4e0a\u7684\u8054\u7cfb\u3002\u7b2c\u4e00\u4f8b\u81f4\u547d\u75c5\u4f8b\u6301\u7eed\u66b4\u9732\u4e8e\u5e02\u573a\uff0c\u56e0\u67097\u5929\u53d1\u70e7\u3001\u54b3\u55fd\u548c\u547c\u5438\u56f0\u96be\u53f2\u800c\u5165\u9662\u3002\u5728\u53d1\u75c55\u5929\u540e\uff0c\u4ed6\u7684\u59bb\u5b50\uff0c\u4e00\u540d\u6ca1\u6709\u5df2\u77e5\u5e02\u573a\u66b4\u9732\u53f2\u768453\u5c81\u5987\u5973\uff0c\u4e5f\u51fa\u73b0\u80ba\u708e\uff0c\u88ab\u9001\u8fdb\u9694\u79bb\u75c5\u623f\u3002<\/p>\n

\u5982\u88681\u6240\u793a\uff0c\u53d1\u75c5\u65f6\u6700\u5e38\u89c1\u7684\u75c7\u72b6\u4e3a\u53d1\u70ed(41\u4f8b\u60a3\u8005\u4e2d\u670940\u4f8b[98%])\u3001\u54b3\u55fd(31\u4f8b[76%])\u548c\u808c\u75db\u6216\u75b2\u52b3(18\u4f8b[44%]);\u8f83\u4e0d\u5e38\u89c1\u7684\u75c7\u72b6\u6709\u75f0(39\u4f8b\u4e2d\u670911\u4f8b[28%])\u3001\u5934\u75db(38\u4f8b\u4e2d\u67093\u4f8b[8%])\u3001\u54af\u8840(39\u4f8b\u4e2d\u67092\u4f8b[5%])\u548c\u8179\u6cfb(38\u4f8b\u4e2d\u67091\u4f8b[3%])\u3002\u5982\u56fe2\u6240\u793a\uff0c\u8d85\u8fc7\u4e00\u534a\u7684\u60a3\u8005(40\u4f8b\u4e2d\u670922\u4f8b[55%])\u51fa\u73b0\u547c\u5438\u56f0\u96be\u3002\u4ece\u53d1\u75c5\u5230\u547c\u5438\u56f0\u96be\u7684\u4e2d\u4f4d\u65f6\u95f4\u4e3a8.0\u5929(IQR 5.0 \u2013\u00a013.0)\u3002\u4ece\u75c7\u72b6\u51fa\u73b0\u5230\u9996\u6b21\u5165\u9662\u65f6\u95f4\u4e2d\u4f4d\u6570\u4e3a7.0\u5929(4.0 \u2013\u00a08.0)\uff0c\u5230\u6c14\u77ed8.0\u5929(5.0 \u2013\u00a013.0)\uff0c\u5230ARDS 9.0\u5929(8.0 \u2013\u00a014.0)\uff0c\u5230\u673a\u68b0\u901a\u6c1410.5\u5929(7.0 \u2013\u00a014.0)\uff0c\u5230ICU\u5165\u966210.5\u5929(8.0 \u2013\u00a017.0))\u3002<\/p>\n

\u56fe1:<\/strong><\/p>\n

\"\"<\/p>\n

\u7ecf\u5b9e\u9a8c\u5ba4\u786e\u8ba4\u76842019-nCoV\u611f\u67d3\u60a3\u8005\u7684\u53d1\u75c5\u65e5\u671f\u548c\u5e74\u9f84\u5206\u5e03(A)\u5404\u5e74\u9f84\u7ec4\u5165\u9662\u4eba\u6570\u3002(B)\u5b9e\u9a8c\u5ba4\u786e\u8bca\u75c5\u4f8b\u7684\u75c7\u72b6\u5f00\u59cb\u65e5\u671f\u7684\u5206\u5e03\u3002\u6b66\u6c49\u5e02\u536b\u751f\u5c40\u4e8e2019\u5e7412\u670830\u65e5\u53d1\u5e03\u6d41\u884c\u75c5\u5b66\u9884\u8b66\uff0c\u5e76\u4e8e2\u5929\u540e\u5173\u95ed\u4e86\u534e\u5357\u6d77\u9c9c\u5e02\u573a\u3002<\/p>\n

\u88681:2019-nCoV\u60a3\u8005\u7684\u4eba\u53e3\u5b66\u7279\u5f81\u548c\u57fa\u7ebf\u7279\u5f81<\/strong><\/p>\n

\"\"<\/p>\n

\u56fe2:2019-nCoV\u53d1\u75c5\u540e\u75c5\u4f8b\u7684\u65f6\u95f4\u7ebf<\/strong><\/p>\n

\"\"<\/p>\n

\u4ed6\u4eec\u5728\u6b64\u62a5\u544a41\u4f8b\u5b9e\u9a8c\u5ba4\u786e\u8bca\u76842019-nCoV\u611f\u67d3\u60a3\u8005\u3002\u60a3\u8005\u60a3\u6709\u4e25\u91cd\u7684\u3001\u6709\u65f6\u751a\u81f3\u81f4\u547d\u7684\u80ba\u708e\uff0c\u5e76\u4e8e2020\u5e741\u67082\u65e5\u524d\u88ab\u9001\u5165\u4e2d\u56fd\u6b66\u6c49\u7684\u6307\u5b9a\u533b\u9662\u3002\u4e34\u5e8a\u8868\u73b0\u4e0eSARS-CoV\u6781\u4e3a\u76f8\u4f3c\u3002\u91cd\u75c7\u60a3\u8005\u51fa\u73b0ARDS\uff0c\u9700\u8981ICU\u4f4f\u9662\u548c\u6c27\u7597\u3002\u5165\u9662\u81f3ARDS\u7684\u65f6\u95f4\u6700\u77ed\u4e3a2\u5929\u3002\u5728\u8fd9\u4e2a\u9636\u6bb5\uff0c2019-nCoV\u7684\u6b7b\u4ea1\u7387\u5f88\u9ad8\uff0c\u56e0\u4e3a41\u4f8b\u60a3\u8005\u4e2d\u67096\u4f8b(15%)\u6b7b\u4ea1\u3002<\/p>\n

\u7531\u4e8e2019-nCoV\u662f\u4e00\u79cd\u65b0\u51fa\u73b0\u7684\u75c5\u6bd2\uff0c\u76ee\u524d\u8fd8\u6ca1\u6709\u9488\u5bf9\u8be5\u75c5\u6bd2\u5f15\u8d77\u7684\u75be\u75c5\u7684\u6709\u6548\u6cbb\u7597\u65b9\u6cd5\u3002\u7531\u4e8e\u6d1b\u5421\u90a3\u97e6\u548c\u5229\u6258\u90a3\u97e6\u7684\u8054\u5408\u7528\u836f\u5df2\u7ecf\u5728\u6307\u5b9a\u7684\u533b\u9662\u4e2d\u53ef\u7528\uff0c\u4e00\u9879\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u5df2\u7ecf\u8fc5\u901f\u542f\u52a8\uff0c\u4ee5\u8bc4\u4f30\u6d1b\u5421\u90a3\u97e6\u548c\u5229\u6258\u90a3\u97e6\u8054\u5408\u7528\u836f\u5bf92019-nCoV\u611f\u67d3\u4f4f\u9662\u60a3\u8005\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u3002<\/p>\n

3\u3001\u6765\u81ea\u7231\u8377\u534e\u5927\u5b66\u5fae\u751f\u7269\u4e0e\u514d\u75ab\u5b66\u7cfb\u7684Stanley Perlman\u533b\u5b66\u535a\u58eb\u5728The New England Journal of Medicine\u4e0a\u53d1\u8868\uff1aAnother Decade, Another Coronavirus\uff08\u53c8\u4e00\u4e2a\u5341\u5e74\uff0c\u53c8\u4e00\u79cd\u51a0\u72b6\u75c5\u6bd2\uff09\u3002<\/strong><\/p>\n

\u4ed6\u8868\u793a\u8fd9\u662f\u51e0\u5341\u5e74\u6765\u7b2c\u4e09\u6b21\u4eba\u755c\u5171\u60a3\u75c5\u51a0\u72b6\u75c5\u6bd2\u8de8\u8d8a\u7269\u79cd\u611f\u67d3\u4eba\u7c7b\u3002\u8fd9\u79cd\u75c5\u6bd2\u6682\u65f6\u88ab\u79f0\u4e3a2019-nCoV\uff0c\u6700\u521d\u5728\u4e2d\u56fd\u6b66\u6c49\u7684\u6d77\u9c9c\u5e02\u573a\u6216\u83dc\u5e02\u573a\u53d1\u73b0\u3002\u4e2d\u56fd\u516c\u5171\u536b\u751f\u3001\u4e34\u5e8a\u548c\u79d1\u5b66\u754c\u7684\u5feb\u901f\u53cd\u5e94\u4fc3\u8fdb\u4e86\u5bf9\u4e34\u5e8a\u75be\u75c5\u7684\u8ba4\u8bc6\u548c\u5bf9\u611f\u67d3\u6d41\u884c\u75c5\u5b66\u7684\u521d\u6b65\u4e86\u89e3\u3002\u6700\u521d\u7684\u62a5\u544a\u8868\u660e\uff0c\u4eba\u4f20\u4eba\u662f\u6709\u9650\u7684\u6216\u4e0d\u5b58\u5728\uff0c\u4f46\u6211\u4eec\u73b0\u5728\u77e5\u9053\uff0c\u8fd9\u79cd\u4f20\u64ad\u53d1\u751f\u4e86\uff0c\u5c3d\u7ba1\u5728\u4f55\u79cd\u7a0b\u5ea6\u4e0a\u4ecd\u4e0d\u6e05\u695a\u3002\u4e0e\u53e6\u5916\u4e24\u79cd\u81f4\u75c5\u6027\u4eba\u7c7b\u547c\u5438\u9053\u51a0\u72b6\u75c5\u6bd2(SARS-CoV)\u548c\u4e2d\u4e1c\u547c\u5438\u7efc\u5408\u5f81\u51a0\u72b6\u75c5\u6bd2(MERS-CoV)\u5f15\u8d77\u7684\u75ab\u60c5\u4e00\u6837\uff0c2019-nCoV\u5f15\u8d77\u7684\u547c\u5438\u9053\u75be\u75c5\u5f80\u5f80\u662f\u4e25\u91cd\u7684\u3002\u622a\u81f32020\u5e741\u670824\u65e5\uff0c\u62a5\u544a\u7684\u75c5\u4f8b\u8d85\u8fc7800\u4f8b\uff0c\u6b7b\u4ea1\u7387\u4e3a3%\u3002<\/p>\n

\u6b63\u5982\u73b0\u5728\u5728\u6742\u5fd7\u4e0a\u62a5\u9053\u7684\uff0cZhu\u7b49\u4eba\u5df2\u7ecf\u9274\u5b9a\u5e76\u8868\u5f81\u4e862019-nCoV\u3002\u75c5\u6bd2\u57fa\u56e0\u7ec4\u5df2\u7ecf\u6d4b\u5e8f\uff0c\u8fd9\u4e9b\u7ed3\u679c\u4e0e\u5176\u4ed6\u62a5\u544a\u663e\u793a\uff0c\u5b83\u4e0eSARS-CoV\u670975%\u523080%\u7684\u76f8\u540c\uff0c\u751a\u81f3\u4e0e\u51e0\u79cd\u8759\u8760\u51a0\u72b6\u75c5\u6bd2\u6709\u66f4\u5bc6\u5207\u7684\u5173\u7cfb\u3002\u5b83\u53ef\u4ee5\u5728\u4e0e\u751f\u957fSARS-CoV\u548cMERS-CoV\u76f8\u540c\u7684\u7ec6\u80de\u4e2d\u7e41\u6b96\uff0c\u4f46\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c2019-nCoV\u5728\u4eba\u6c14\u9053\u539f\u4ee3\u4e0a\u76ae\u7ec6\u80de\u4e2d\u6bd4\u5728\u6807\u51c6\u7ec4\u7ec7\u57f9\u517b\u7ec6\u80de\u4e2d\u751f\u957f\u5f97\u66f4\u597d\uff0c\u4e0d\u50cfSARS-CoV\u6216MERS-CoV\u3002\u75c5\u6bd2\u7684\u9274\u5b9a\u5c06\u4f7f\u8bd5\u5242\u7684\u53d1\u5c55\u80fd\u591f\u89e3\u51b3\u5173\u4e8e\u8fd9\u79cd\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u611f\u67d3\u7684\u5173\u952e\u672a\u77e5\u56e0\u7d20\uff0c\u5e76\u6307\u5bfc\u6297\u75c5\u6bd2\u6cbb\u7597\u7684\u53d1\u5c55\u3002\u9996\u5148\uff0c\u4e86\u89e3\u57fa\u56e0\u7ec4\u5e8f\u5217\u6709\u52a9\u4e8e\u5f00\u53d1\u654f\u611f\u7684\u5b9a\u91cf\u9006\u8f6c\u5f55\u9176\u805a\u5408\u9176\u94fe\u53cd\u5e94\u6d4b\u5b9a\u6cd5\uff0c\u4ece\u800c\u5feb\u901f\u68c0\u6d4b\u75c5\u6bd2\u3002\u7b2c\u4e8c\uff0c\u8840\u6e05\u5b66\u5316\u9a8c\u7684\u53d1\u5c55\u5c06\u6709\u52a9\u4e8e\u8bc4\u4f30\u4eba\u7c7b\u611f\u67d3\u7684\u6d41\u884c\u7a0b\u5ea6\uff0c\u4ee5\u53ca\u5728\u83dc\u5e02\u573a\u548c\u5176\u4ed6\u73af\u5883\u4e2d\u75c5\u6bd2\u7684\u6f5c\u5728\u4eba\u755c\u5171\u60a3\u75c5\u6e90\u3002\u8fd9\u4e9b\u8bd5\u5242\u4e5f\u5c06\u6709\u52a9\u4e8e\u8bc4\u4f30\u4eba\u7c7b\u611f\u67d3\u662f\u5426\u6bd4\u539f\u6765\u8ba4\u4e3a\u7684\u66f4\u5e7f\u6cdb\uff0c\u56e0\u4e3a\u4e2d\u56fd\u5404\u5730\u90fd\u6709\u83dc\u5e02\u573a\u3002\u7b2c\u4e09\uff0c\u6709\u4e86\u8fd9\u79cd\u75c5\u6bd2\uff0c\u5c31\u4f1a\u4fc3\u4f7f\u4eba\u4eec\u52aa\u529b\u5f00\u53d1\u6297\u75c5\u6bd2\u7597\u6cd5\u548c\u75ab\u82d7\uff0c\u4ee5\u53ca\u5b9e\u9a8c\u52a8\u7269\u6a21\u578b\u3002<\/p>\n

\u5173\u4e8e\u8fd9\u79cd\u611f\u67d3\u8fd8\u6709\u5f88\u591a\u9700\u8981\u4e86\u89e3\u3002\u6700\u91cd\u8981\u7684\u662f\uff0c\u9700\u8981\u786e\u5b9a\u4eba\u9645\u4f20\u64ad\u7684\u7a0b\u5ea6\u548c\u4e34\u5e8a\u75be\u75c5\u7684\u8303\u56f4\u3002SARS-CoV\u548cMERS-CoV\u7684\u4f20\u64ad\u5728\u5f88\u5927\u7a0b\u5ea6\u4e0a\u662f\u901a\u8fc7\u8d85\u4f20\u64ad\u4e8b\u4ef6\u53d1\u751f\u7684\u30022019-nCoV\u7684\u4f20\u64ad\u6d89\u53ca5\u4e2a\u8d85\u7ea7\u4f20\u64ad\u4e8b\u4ef6\uff0c\u4f46\u5b83\u4eec\u7684\u76f8\u5bf9\u91cd\u8981\u6027\u5c1a\u4e0d\u6e05\u695a\u3002SARS-CoV\u548cMERS-CoV\u611f\u67d3\u80ba\u5185\u4e0a\u76ae\u7ec6\u80de\u5747\u591a\u4e8e\u611f\u67d3\u4e0a\u547c\u5438\u9053\u7ec6\u80de\u3002\u56e0\u6b64\uff0c\u4f20\u64ad\u4e3b\u8981\u53d1\u751f\u5728\u5df2\u786e\u8bca\u7684\u75c5\u4eba\u8eab\u4e0a\uff0c\u800c\u4e0d\u662f\u53d1\u751f\u5728\u6709\u8f7b\u5fae\u3001\u975e\u7279\u5f02\u6027\u75c7\u72b6\u7684\u75c5\u4eba\u8eab\u4e0a\u3002\u770b\u67652019-nCoV\u4f7f\u7528\u4e0eSARS-CoV(\u4eba\u8840\u7ba1\u7d27\u5f20\u7d20\u8f6c\u6362\u91762 [hACE2])\u76f8\u540c\u7684\u7ec6\u80de\u53d7\u4f53\uff0c\u56e0\u6b64\u53ea\u6709\u5728\u4e0b\u547c\u5438\u9053\u75be\u75c5\u51fa\u73b0\u75c7\u72b6\u540e\u624d\u53ef\u80fd\u4f20\u64ad\u3002SARS-CoV\u57282002-2004\u5e74\u7684\u6d41\u884c\u671f\u95f4\u53d1\u751f\u7a81\u53d8\uff0c\u4ee5\u66f4\u597d\u5730\u4e0e\u5176\u7ec6\u80de\u53d7\u4f53\u7ed3\u5408\uff0c\u5e76\u4f18\u5316\u4eba\u7c7b\u7ec6\u80de\u7684\u590d\u5236\uff0c\u589e\u5f3a\u6bd2\u6027\u3002\u7531\u4e8e\u51a0\u72b6\u75c5\u6bd2\u5177\u6709\u5bb9\u6613\u51fa\u9519\u7684RNA\u4f9d\u8d56RNA\u805a\u5408\u9176\uff0c\u4f7f\u5f97\u7a81\u53d8\u548c\u91cd\u7ec4\u4e8b\u4ef6\u9891\u7e41\u53d1\u751f\uff0c\u56e0\u6b64\u5f88\u5bb9\u6613\u53d1\u751f\u9002\u5e94\u6027\u53d8\u5316\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0cMERS-CoV\u81ea2012\u5e74\u88ab\u53d1\u73b0\u4ee5\u6765\uff0c\u5e76\u6ca1\u6709\u53d1\u751f\u663e\u8457\u7684\u7a81\u53d8\u6765\u589e\u5f3a\u4eba\u7c7b\u7684\u4f20\u67d3\u6027\u3002<\/p>\n

\u975e\u5178\u75ab\u60c5\u7684\u4e00\u4e2a\u663e\u8457\u7279\u5f81\u662f\uff0c\u6050\u60e7\u5728\u7ecf\u6d4e\u548c\u793e\u4f1a\u540e\u679c\u4e2d\u626e\u6f14\u4e86\u91cd\u8981\u89d2\u8272\u3002\u867d\u7136\u5177\u4f53\u7684\u6297\u75c5\u6bd2\u7597\u6cd5\u4ecd\u5728\u53d1\u5c55\u4e2d\uff0c\u4f46\u6211\u4eec\u73b0\u5728\u77e5\u9053\u4e86\u66f4\u591a\u5173\u4e8e\u5982\u4f55\u5728\u793e\u533a\u548c\u533b\u9662\u63a7\u5236\u8fd9\u7c7b\u611f\u67d3\u7684\u77e5\u8bc6\uff0c\u8fd9\u5e94\u8be5\u4f1a\u51cf\u8f7b\u8fd9\u79cd\u6050\u60e7\u3002\u6839\u636e\u6211\u4eec\u5bf9SARS-CoV\u548cMERS-CoV\u7684\u7ecf\u9a8c\uff0c2019-nCoV\u7684\u4f20\u64ad\u53ef\u80fd\u901a\u8fc7\u5927\u6db2\u6ef4\u548c\u63a5\u89e6\u53d1\u751f\uff0c\u8f83\u5c11\u901a\u8fc7\u6c14\u6eb6\u80f6\u548c\u6c61\u67d3\u7269\u53d1\u751f\u30024\u30015\u9879\u516c\u5171\u536b\u751f\u63aa\u65bd\uff0c\u5305\u62ec\u793e\u533a\u9694\u79bb\u3001\u53ca\u65f6\u8bca\u65ad\u548c\u4e25\u683c\u9075\u5b88\u536b\u751f\u4fdd\u5065\u673a\u6784\u7684\u666e\u904d\u9884\u9632\u63aa\u65bd\uff0c\u5bf9\u63a7\u5236SARS\u548cMERS\u81f3\u5173\u91cd\u8981\u3002\u5236\u5b9a\u7c7b\u4f3c\u7684\u63aa\u65bd\u5c06\u662f\u91cd\u8981\u7684\uff0c\u5e76\u5e0c\u671b\u5728\u51cf\u5c112019-nCoV\u7684\u4f20\u64ad\u65b9\u9762\u53d6\u5f97\u6210\u529f\u3002<\/p>\n

4\u3001\u7f8e\u56fd\u56fd\u5bb6\u536b\u751f\u7814\u7a76\u9662\u56fd\u5bb6\u8fc7\u654f\u4e0e\u4f20\u67d3\u75c5\u7814\u7a76\u6240\u5fae\u751f\u7269\u5b66\u5b9e\u9a8c\u5ba4\u3001\u8377\u5170\u9e7f\u7279\u4e39\u4f0a\u62c9\u65af\u8c1f\u533b\u5b66\u4e2d\u5fc3\u75c5\u6bd2\u5b66\u90e8\u7684Vincent J. Munster\u7b49\u4eba\u5728The New England Journal of Medicine\u4e0a\u53d1\u8868\uff1aA Novel Coronavirus Emerging in China \u2014 Key Questions for Impact Assessment\uff08\u4e00\u79cd\u65b0\u7684\u51a0\u72b6\u75c5\u6bd2\u5728\u4e2d\u56fd\u51fa\u73b0\u2014\u2014\u5f71\u54cd\u8bc4\u4f30\u7684\u5173\u952e\u95ee\u9898\uff09\u3002<\/strong><\/p>\n

\u5728\u6b66\u6c49\u9996\u6b21\u62a5\u544a\u4e86\u4e00\u79cd\u7c7b\u4f3cSARS\u7684\u75c5\u6bd2\u51fa\u73b0\u540e\uff0c2019-nCoV\u7684\u81f4\u75c5\u6027\u53ef\u80fd\u4f4e\u4e8eMERS-CoV\u548cSARS-CoV(\u89c1\u88682)\u3002<\/p>\n

\u88682.\u65b0\u8fd1\u51fa\u73b0\u7684\u75c5\u6bd2\u7684\u81f4\u75c5\u6027\u548c\u4f20\u64ad\u7279\u6027\u4e0e\u66b4\u53d1\u63a7\u5236\u6709\u5173<\/strong><\/p>\n

\"\"<\/p>\n

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\u56fe3. \u76d1\u6d4b\u91d1\u5b57\u5854\u53ca\u5176\u4e0e\u75ab\u60c5\u63a7\u5236\u7684\u5173\u7cfb<\/strong><\/p>\n

\"\"<\/p>\n

(\u5bf9\u4e8e2019-nCoV\uff0c\u76ee\u524d\u5c1a\u4e0d\u6e05\u695a\u8f7b\u5ea6\u548c\u65e0\u75c7\u72b6\u75c5\u4f8b\u4e0e\u4e25\u91cd\u548c\u81f4\u547d\u75c5\u4f8b\u7684\u6bd4\u4f8b\u3002\u8fd9\u4e00\u77e5\u8bc6\u7f3a\u53e3\u59a8\u788d\u5bf9\u75c5\u6bd2\u6d41\u884c\u6f5c\u529b\u7684\u73b0\u5b9e\u8bc4\u4f30\uff0c\u5e76\u4f7f\u75ab\u60c5\u5e94\u5bf9\u590d\u6742\u5316\u3002)<\/p>\n

\u663e\u7136\uff0c\u6709\u6548\u7684\u4eba\u9645\u4f20\u64ad\u662f\u8fd9\u4e00\u65b0\u5174\u75c5\u6bd2\u5927\u89c4\u6a21\u4f20\u64ad\u7684\u5fc5\u8981\u6761\u4ef6\u3002\u7136\u800c, \u75c5\u6bd2\u4f20\u64ad\u80fd\u529b\u662f\u5f71\u54cd\u75be\u75c5\u4e25\u91cd\u7a0b\u5ea6\u7684\u4e00\u4e2a\u91cd\u8981\u7684\u95f4\u63a5\u56e0\u7d20\uff0c\u4e5f\u662f\u5f71\u54cd\u6211\u4eec\u8bc6\u522b\u5e76\u63a7\u5236\u611f\u67d3\u8005\u7684\u4e00\u4e2a\u91cd\u8981\u56e0\u7d20:\u65e0\u8bba\u66b4\u53d1\u662f\u7531\u5355\u4e2a\u6ea2\u51fa\u4e8b\u4ef6(SARS-CoV)\u8fd8\u662f\u7531\u91cd\u590d\u8de8\u8d8a\u7269\u79cd\u5c4f\u969c(MERS-CoV)\u5f15\u8d77\uff0c\u90fd\u662f\u9002\u7528\u7684\u3002<\/p>\n

5\u3001\u53c2\u8003\u6587\u732e<\/strong><\/p>\n

[1]\u00a0C. Huang, Y. Wang, X. Li, et al.\u00a0Lancet<\/i><\/em>, January 24, 2020. https:\/\/doi.org\/10.1016\/S0140-6736 (20) 30183-5.<\/p>\n

[2] S. Perlman. N. Engl. J. Med<\/i><\/em>.\u00a0<\/i><\/em>January 24, 2020. DOI: 10.1056\/NEJMe2001126.<\/p>\n

[3] N. Zhu, D. Zhang, W. Wang, et al.\u00a0N. Engl. J. Med<\/i><\/em>.\u00a0<\/i><\/em>January 24, 2020. DOI: 10.1056\/NEJMoa2001017.<\/p>\n

[4] V.J. Munster, M. Koopmans, N. Doremalen, et al. N. Engl. J. Med<\/i><\/em>.\u00a0<\/i><\/em>January 24, 2020.\u00a0DOI: 10.1056\/NEJMp2000929.<\/p>\n

\u672c\u6587\u7531Yun<\/strong>\u4f9b\u7a3f\u3002<\/p>\n

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