{"id":195356,"date":"2020-02-04T06:24:05","date_gmt":"2020-02-03T22:24:05","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=195356"},"modified":"2020-02-03T22:24:43","modified_gmt":"2020-02-03T14:24:43","slug":"adv-mater-%e6%8a%a5%e9%81%93%ef%bc%9a%e4%bb%bf%e7%83%9f%e8%8d%89%e8%8a%b1%e5%8f%b6%e7%97%85%e6%af%92%e7%9a%84%e7%ad%96%e7%95%a5%e7%94%a8%e4%ba%8e%e6%b2%bb%e7%96%97%e5%a4%9a%e8%8d%af%e8%80%90%e8%8d%af","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=195356","title":{"rendered":"Adv. Mater.\u62a5\u9053\uff1a\u4eff\u70df\u8349\u82b1\u53f6\u75c5\u6bd2\u7684\u7b56\u7565\u7528\u4e8e\u6cbb\u7597\u591a\u836f\u8010\u836f\u764c\u75c7"},"content":{"rendered":"

\u3010\u80cc\u666f\u4ecb\u7ecd\u3011<\/strong><\/p>\n

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\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

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\u3010\u56fe\u6587\u89e3\u8bfb\u3011<\/strong><\/p>\n

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\n \"\"\uff08A\uff09ATMVs\u7684\u5236\u5907\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08B\uff09\u7ec6\u80de\u95f4\u548c\u80bf\u7624\u5185\u90e8\u7684\u6eb6\u7624\u793a\u610f\u56fe\u3002<\/p>\n

\u56fe\u4e8c\u3001ATMVs\u7684\u7eb3\u7c73\u7ed3\u6784\u548c\u91ca\u653e\u6548\u679c<\/strong>
\n \"\"\uff08A\uff09SWNT-Rs\u3001SSAPs\u548cATMVs\u6eb6\u6db2\u7684\u7d2b\u5916\u53ef\u89c1\u5438\u6536\u5149\u8c31\u548c\u8367\u5149\u5149\u8c31\uff1b<\/p>\n

\uff08B\uff09SWNT-Rs\u548cATMVs\u7684TEM\u56fe\u50cf\u4ee5\u53caATMVs\u7684AFM\u56fe\u50cf\uff1b<\/p>\n

\uff08C\uff09ATMVs\u7684CD\u5149\u8c31\uff1b<\/p>\n

\uff08D\uff09ATMVs\u6eb6\u6db2\u5728808 nm\uff082.0 W cm-2<\/sup>\uff0c7 min\uff09\u6fc0\u5149\u7167\u5c04\u4e0b\u7684\u5149\u70ed\u66f2\u7ebf\uff0c\u4ee5\u53ca\u7ebf\u6027\u65f6\u95f4\u6570\u636e\u76f8\u5bf9\u4e8e\u51b7\u5374\u8fc7\u7a0b\u7684-ln(\u03b8)\uff08\u03c4s<\/sub>=342.25 s\uff09\uff1b<\/p>\n

\uff08E\uff09\u5f53pH\u4ece\u751f\u7406\u6761\u4ef6\uff08pH=7.4\uff09\u53d8\u4e3a\u9178\u6027\uff08pH=6.5\uff09\u65f6\uff0cATMVs\u7684\u8868\u9762\u7535\u8377\u53cd\u8f6c\uff1b<\/p>\n

\uff08F\uff09\u5f53\u66b4\u9732\u4e8e\u9178\uff08pH=6.5\uff0cpH=5.0\uff09\u548c\u8fd1\u7ea2\u5916\u8f90\u5c04\uff082.0 W cm-2<\/sup>\uff09\u65f6\uff0cDOX\u91ca\u653e\u3002<\/p>\n

\u56fe\u4e09\u3001ATMVs\u7684\u4f53\u5916\u4fb5\u67d3\u8fc7\u7a0b<\/strong>
\n \"\"\uff08A\uff09\u5404\u79cd\u5bf9\u7167\u7ec4\u6750\u6599\u5904\u74062 h\u540e\uff0c\u5229\u7528\u8367\u5149\u5f3a\u5ea6\u548c\u62c9\u66fc\u5149\u8c31\u5bf9cellar\u5438\u6536\u8fdb\u884c\u5b9a\u91cf\uff1b<\/p>\n

\uff08B\uff09\u5728\u6709\u65e0\u8fd1\u7ea2\u5916\u8f90\u5c04\u4e0b\uff0c\u7528ATMVs\u5904\u74062 h\u540e\uff0cLoVo\/Adr\u7ec6\u80de\u7684LDH\u6cc4\u6f0f\u548cSEM\u56fe\u50cf\uff1b<\/p>\n

\uff08C\uff09LoVo\/Adr\u7ec6\u80de\u7684TEM\u56fe\u50cf\u663e\u793a\uff0cATMVs\u5904\u740624 h\u540e\uff0cATMVs\u7c98\u9644\u5e76\u7834\u574f\u4e86\u7ec6\u80de\u819c\u4ee5\u53ca\u4e25\u91cd\u7684ER\u7c97\u7cd9\u6269\u5c55\uff1b<\/p>\n

\uff08D\uff09LoVo\/Adr\u7ec6\u80de\u4e0eATMVs\u548cSSAPs\u5b75\u80b20.5\u30016h\u540e\u76842PLSM\u56fe\u50cf\uff1b<\/p>\n

\uff08E\uff09\u5728\u4e0eSSAPs\u3001ATMVs\u548cATMVs\u4e00\u8d77\u5728NIR\u7167\u5c04\u4e0b\u5b75\u80b224 h\u540e\uff0cLoVo\/Adr\u7684CLSM\u56fe\u50cf\uff1b<\/p>\n

\uff08F\uff09\u7528ATMVs\u548cSSAPs\u9884\u5904\u7406\u7684\u7ec6\u80de\u7684\u8367\u5149\u56fe\u50cf1 h\uff0c\u7136\u540e\u5728\u6709\u65e0NIR\u7167\u5c04\u7684\u60c5\u51b5\u4e0b\u5b75\u80b20\u30011\u30013\u30016\u30019\u548c12 h\u3002<\/p>\n

\uff08G\uff09\u7528DOX\u00b7HCl\u3001ATMVs\u548cATMVs\u5728\u6fc0\u5149\u7167\u5c04\u4e0b\u5904\u740624 h\u7684LoVo\/Adr\u7ec6\u80de\u7684CLSM\u56fe\u50cf\uff1b<\/p>\n

\uff08H\uff09\u5728\u7528\u5404\u79cd\u5236\u5242\u5904\u740648 h\u540e\uff0c\u4f7f\u7528Annexin V\/7AAD\u68c0\u6d4b\u5206\u6790\u548c\u6d41\u5f0f\u7ec6\u80de\u672f\u5206\u6790LoVo\/Adr\u7ec6\u80de\u7684\u51cb\u4ea1\u3002<\/p>\n

\u56fe\u56db\u3001ATMVs\u7684\u6e17\u900f\u6548\u679c<\/strong>
\n \"\"\uff08A\uff09\u5206\u522b\u4e0eDOX\u00b7HCl\u3001SSAP\u548cATMVs\u5b75\u80b21 h\u7684\u9884\u5904\u7406\u7ec6\u80de\u6269\u6563\u81f3\u90bb\u8fd1\u7ec6\u80de\u7684\u6d4b\u8bd5\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08B\uff09\u6d41\u5f0f\u7ec6\u80de\u4eea\u6d4b\u8bd5\u4e86\u5728A\u5b54\u548cB\u5b54\u5171\u57f9\u517b12 h\u540eDOX\u9633\u6027\u7ec6\u80de\u7684\u901f\u7387\uff0c\u4ee5\u53ca\u5728A\u5b54\u548cB\u5b54\u5171\u57f9\u517b48 h\u4e4b\u540e\u7684\u6d3b\/\u6b7b\u7ec6\u80de\u7684\u901f\u7387\uff1b<\/p>\n

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\u6587\u732e\u94fe\u63a5\uff1aBioinspired Artificial Tobacco Mosaic Virus with Combined Oncolytic Properties to Completely Destroy Multidrug-Resistant Cancer<\/a><\/strong>.\uff08Adv. Mater.<\/em>, 2020<\/strong>, DOI: 10.1002\/adma.201904958\uff09<\/p>\n

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