{"id":196130,"date":"2020-04-08T06:10:46","date_gmt":"2020-04-07T22:10:46","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=196130"},"modified":"2020-04-07T20:11:30","modified_gmt":"2020-04-07T12:11:30","slug":"%e5%8d%97%e4%ba%ac%e5%8c%bb%e7%a7%91%e5%a4%a7%e5%8c%97%e8%88%aa%e7%ad%89-nat-commun-%ef%bc%9a%e8%a1%80%e6%b6%b2%e4%b8%ad%e8%a7%a6%e5%8f%91%e7%94%9f%e6%88%90%e5%85%b7%e6%9c%89%e6%8a%97%e7%99%8c","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=196130","title":{"rendered":"\u5357\u4eac\u533b\u79d1\u5927&\u5317\u822a\u7b49 Nat. Commun.\uff1a\u8840\u6db2\u4e2d\u89e6\u53d1\u751f\u6210\u5177\u6709\u6297\u764c\u4f5c\u7528\u7684\u94c2\u7eb3\u7c73\u9897\u7c92"},"content":{"rendered":"

\u3010\u80cc\u666f\u4ecb\u7ecd\u3011<\/strong><\/p>\n

\u968f\u7740\u7eb3\u7c73\u79d1\u5b66\u6280\u672f\u7684\u8fc5\u901f\u53d1\u5c55\uff0c\u91d1\u5c5e\u6216\u91d1\u5c5e\u5316\u5408\u7269\u7eb3\u7c73\u9897\u7c92\uff08NPs\uff09\u5728\u6d3b\u751f\u7269\u4f53\u4e2d\u7684\u4f7f\u7528\u4e5f\u6b63\u5728\u8fc5\u901f\u589e\u52a0\u3002\u81ea\u4ece\u5728\u4eba\u8111\u4e2d\u53d1\u73b0\u78c1\u94c1\u77ff\u9897\u7c92\u540e\uff0c\u7814\u7a76\u5df2\u53d1\u73b0\u5176\u662f\u6c27\u5316\u8fd8\u539f\u6d3b\u6027\u3001\u8868\u9762\u7535\u8377\u548c\u78c1\u6027\u884c\u4e3a\u7684\u72ec\u7279\u7ec4\u5408\uff0c\u5e76\u6697\u793a\u7740\u91d1\u5c5eNPs\u53ef\u4ee5\u5b89\u5168\u5730\u5e94\u7528\u4e8e\u4eba\u4f53\u3002\u4e8b\u5b9e\u4e0a\uff0c\u6297\u764c\u836f-\u987a\u94c2\uff08Pt\uff09\u3001\u4e2d\u836f\u4f7f\u7528\u6c5e\u4f50\u5242\u3001\u653e\u5c04\u5b66\u4e2d\u4f7f\u7528\u542b\u9486\u9020\u5f71\u5242\u90fd\u542b\u6709\u91cd\u91d1\u5c5e\u3002\u987aPt\u5df2\u7ecf\u88ab\u6279\u51c6\u4f5c\u4e3a\u5375\u5de2\u764c\u3001\u777e\u4e38\u764c\u3001\u80ba\u764c\u7b49\u764c\u75c7\u7684\u4e00\u7ebf\u6cbb\u7597\u836f\u7269\uff0c\u4ece\u800c\u4ea7\u751f\u4e86\u591a\u79cd\u57fa\u4e8e\u987aPt\u7684\u590d\u5408\u7269\u3002<\/p>\n

\u5df2\u6709\u7814\u7a76\u53d1\u73b0\u57fa\u4e8e\u91d1\u5c5e\u7684\u7269\u7406\u5316\u5b66\u6027\u8d28\uff0c\u751f\u7406\u73af\u5883\u6709\u5229\u4e8e\u5c06\u5176\u8f6c\u5316\u4e3a\u91d1\u5c5eNPs\u3002\u7814\u7a76\u53d1\u73b0\uff0c\u5f53\u5728\u6c34\u6eb6\u6db2\u4e2d\u52a0\u5165Zn\u79bb\u5b50\u65f6\uff0c\u4f1a\u81ea\u53d1\u751f\u6210ZnO NPs\uff08bio-ZnO NPs\uff09\u3002\u6b64\u5916\uff0cNPs\u901a\u5e38\u5728\u5faa\u73af\u4e2d\u88ab\u86cb\u767d\u8d28\u7535\u6655\u8986\u76d6\u3002\u6709\u8da3\u7684\u662f\uff0c\u57fa\u4e8e\u8d35\u91d1\u5c5e\u7684NPs\uff08Pt\u3001Au\u3001Ag\u7b49\uff09\u53ef\u4ee5\u81ea\u53d1\u5438\u6536\u8c37\u80f1\u7518\u80bd\uff08GSH\uff09\uff0c\u800c\u5def\u57fa\u4f5c\u4e3a\u5c01\u7aef\u914d\u4f53\uff0c\u6709\u52a9\u4e8e\u764c\u75c7\u6cbb\u7597\u3002\u7136\u800c\uff0c\u8fd9\u4e9b\u91d1\u5c5eNPs\u5b58\u5728\u7684\u672a\u77e5\u6bd2\u6027\u3001\u6210\u672c\u548c\u4eba\u7c7b\u7814\u7a76\u7684\u9053\u5fb7\u969c\u788d\u963b\u788d\u4e86\u5176\u4e34\u5e8a\u8f6c\u5316\u5e94\u7528\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u57fa\u4e8e\u6b64\uff0c\u5357\u4eac\u533b\u79d1\u5927\u5b66\u7684\u5f20\u6839\u8bb2\u5e08\u548c\u5434\u827a\u821f\u8bb2\u5e08\u3001\u5317\u4eac\u822a\u7a7a\u822a\u5929\u5927\u5b66\u7684\u4ed8\u7389\u660e\u526f\u6559\u6388\u4ee5\u53ca\u56fd\u5bb6\u7eb3\u7c73\u79d1\u5b66\u4e2d\u5fc3\u7684\u8042\u5e7f\u519b\u7814\u7a76\u5458\uff08\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u8054\u5408\u62a5\u9053\u4e86\u5f53\u5229\u7528\u987aPt\u6cbb\u7597\u60a3\u8005\u65f6\uff0c\u5728\u4eba\u4f53\u8840\u6db2\u4e2d\u4f53\u5185\u68c0\u6d4b\u5230\u751f\u7269\u5f62\u6210\u7684Pt NPs\u3002\u8fd9\u4e9b\u81ea\u7ec4\u88c5\u8fc5\u901f\u5f62\u6210\u7684Pt NPs\uff0c\u5728\u80bf\u7624\u5904\u7d2f\u79ef\uff0c\u5177\u6709\u8f83\u957f\u7684\u5faa\u73af\u534a\u8870\u671f\uff0c\u5e76\u4e14\u80fd\u901a\u8fc7\u80be\u5c0f\u7403\u6ee4\u8fc7\u5c4f\u969c\u8fdb\u884c\u7f13\u6162\u7684\u6e17\u900f\u3002\u6b64\u5916\uff0cPt NPs\u5728\u4eba\u7c7b\u4e2d\u662f\u5b89\u5168\u4f7f\u7528\u7684\uff0c\u53ef\u4ee5\u901a\u8fc7\u6d88\u8017\u7ec6\u80de\u5185\u7684\u8c37\u80f1\u7518\u80bd\uff08GSH\uff09\u548c\u6fc0\u6d3b\u7ec6\u80de\u51cb\u4ea1\u6765\u5145\u5f53\u6297\u764c\u5242\uff0c\u4ee5\u6291\u5236\u5bf9\u5316\u7597\u8010\u836f\u7684\u80bf\u7624\u751f\u957f\u3002\u5f53Pt NPs\u5728\u4f53\u5916\u8d1f\u8f7d\u5316\u7597\u836f\u7269\uff08\u67d4\u7ea2\u9709\u7d20\uff09\u65f6\uff0c\u6781\u5927\u7684\u589e\u5f3a\u4e86\u5bf9\u80bf\u7624\u7684\u6291\u5236\u6d3b\u6027\uff0c\u8be5\u5236\u5242\u5bf9\u8010\u67d4\u7ea2\u9709\u7d20\u80bf\u7624\u6a21\u578b\u4e5f\u6709\u6548\u3002\u8fd9\u4e9b\u4f53\u5185\u4ea7\u751f\u7684\u91d1\u5c5eNPs\u4ee3\u8868\u4e86\u4e00\u4e2a\u751f\u7269\u76f8\u5bb9\u6027\u7684\u836f\u7269\u9012\u9001\u5e73\u53f0\u5bf9\u5316\u7597\u8010\u836f\u80bf\u7624\u7684\u6cbb\u7597\u3002\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a\u201cBlood-triggered generation of platinum nanoparticle functions as an anti-cancer agent\u201d<\/strong>\u53d1\u5e03\u5728\u56fd\u9645\u8457\u540d\u671f\u520aNature Communications<\/strong>\u4e0a\u3002<\/p>\n

\u3010\u56fe\u6587\u89e3\u8bfb\u3011<\/strong><\/p>\n

\u56fe\u4e00\u3001Pt NPs\u7684\u8868\u5f81<\/strong>
\n \"\"\uff08a\uff09\u4eba\u4f53\u8840\u6db2\u4e2dPt NPs\u7684\u751f\u7269\u5408\u6210\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08b\uff09\u4ece\u60a3\u8005\u8840\u6db2\u4e2d\u5206\u79bb\u51fa\u7684Pt NPs\u7684EDS\u5149\u8c31\uff1b<\/p>\n

\uff08c\uff09\u4ece\u60a3\u8005\u8840\u6db2\u4e2dHPLC\u7eaf\u5316\u7684Pt NPs\u7684\u7d2b\u5916\u53ef\u89c1\u5438\u6536\u5149\u8c31\uff1b<\/p>\n

\uff08d\uff09\u7528DLS\u8868\u5f81\u78f7\u9178\u76d0\u7f13\u51b2\u6db2\u4e2dPt NPs\u7684\u7c92\u5f84\u5206\u5e03\uff1b<\/p>\n

\uff08e\uff09\u70b9\u5370\u8ff9\u6cd5\u68c0\u6d4bPt NPs\u4e2d\u7684\u4eba\u8840\u6e05\u767d\u86cb\u767d\uff1b<\/p>\n

\uff08f\uff09\u901a\u8fc7\u8d28\u8c31\u6cd5\u9274\u5b9aPt NPs\u4e2d\u7684\u767d\u86cb\u767d\u3002<\/p>\n

\u56fe\u4e8c\u3001\u5229\u7528\u987aPt\u5316\u7597\u540e\uff0cPt NPs\u7684\u751f\u7269\u5408\u6210\u548c\u4ee3\u8c22<\/strong>
\n \"\"\uff08a\uff09Pt NPs\u7684\u6210\u6838\u548c\u751f\u957f\u8fc7\u7a0b\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08b\uff09\u5229\u7528\u987aPt\u6cbb\u7597\u540e0.5 h\uff08\u4e0a\uff09\uff0c\u6cbb\u7597\u540e0.5 h\uff08\u4e2d\uff09\u548c\u5c3f\u540e24 h\uff08\u4e0b\uff09\u8840\u6db2\u4e2d\u60a3\u8005\u8840\u6db2\u4e2dPt NPs\u7684\u7c92\u5f84\u5dee\u5f02\uff1b<\/p>\n

\uff08c\uff09\u987aPt\u5316\u7597\u540e30\u5929\u5185\uff0c\u60a3\u8005\u8840\u6db2\u4e2dPt NPs\u7684\u6d53\u5ea6\uff1b<\/p>\n

\uff08d\uff09\u4e0d\u540c\u7c92\u5f84\u5927\u5c0fPt NPs\u7684\u80be\u5c0f\u7403\u6ee4\u8fc7\uff0c\u53d1\u73b0Pt NPs<6 nm\u6bd4Pt NPs>6 nm\u66f4\u5bb9\u6613\u901a\u8fc7GBM\u3002<\/p>\n

\u56fe\u4e09\u3001\u987aPt\u6cbb\u7597\u540e\uff0c\u80be\u5c0f\u7403\u7684\u8d85\u5fae\u7ed3\u6784<\/strong><\/p>\n

\"\"<\/p>\n

\u56fe\u56db\u3001\u4f53\u5185Pt NPs\u7684\u80bf\u7624\u9776\u5411\u548c\u751f\u7269\u5206\u5e03<\/strong>
\n \"\"\uff08a\uff09\u4eba\u80bf\u7624\u5300\u6d46\u4e2dPt NPs\u7684\u4ee3\u8868\u6027TEM\u56fe\u50cf\uff1b<\/p>\n

\uff08b\uff09120 kV bio-TEM\u663e\u793a\u4ece\u5207\u9664\u7684\u60a3\u8005\u80bf\u7624\u7ec4\u7ec7\u4e2d\u79ef\u7d2f\u7684Pt NPs\u5728\u80bf\u7624\u7ec6\u80de\u4e2d\uff1b<\/p>\n

\uff08c\uff09\u5b9a\u91cf\u4eba\u7c7b\u80bf\u7624\u548c\u90bb\u8fd1\u7684\u6b63\u5e38\u7ec4\u7ec7\u4e2d\u7684Pt NPs\uff08n=3\uff09\uff0c*P<0.05\uff1b<\/p>\n

\uff08d\uff09\u5b9a\u91cf\u6d4b\u5b9a\u5c0f\u9f20\u80bf\u7624\u548c\u6b63\u5e38\u90bb\u8fd1\u7ec4\u7ec7\u4e2d\u7684Pt NPs\uff08n=3\uff09\uff0c*P<0.05\uff1b<\/p>\n

\uff08e\uff09\u4e0b\u62c9\u6d4b\u5b9a\u6cd5\u8bc4\u4f30Pt NPs\u4e0eSPARC\u7684\u76f8\u4e92\u4f5c\u7528\uff1b<\/p>\n

\uff08f\uff09\u5728\u9759\u8109\u5185\u6ce8\u5c04NPs\u540e\uff0c\u5728DNR\u8010\u836fK562\u7ec6\u80de\u5f02\u79cd\u79fb\u690d\u88f8\u9f20\u4e2d\u7684125<\/sup>I-Pt NPs\u7684NanoScan SPECT\/CT\u6210\u50cf\uff1b<\/p>\n

\uff08g\uff09C57BL\/6\u5c0f\u9f20\u4e2d64<\/sup>Cu-SA\u548c64<\/sup>Cu-Pt NPs\u7684\u65f6\u95f4\u4f9d\u8d56\u6027\u751f\u7269\u5206\u5e03\u3002<\/p>\n

\u56fe\u4e94\u3001\u4f53\u5185Pt NPs\u7684\u539f\u4f4d\u809d\u80bf\u7624\u9776\u5411<\/strong>
\n \"\"\uff08a\uff095\u53ea\u88f8\u9f20\u7684\u539f\u4f4d\u809d\u80bf\u7624\u7684\u89e3\u5256\u4f4d\u7f6e\u548cMIR\u6210\u50cf\uff1b<\/p>\n

\uff08b\uff09\u9759\u8109\u5185\u6ce8\u5c041 \u03bcmg kg-1<\/sup> ICG\u7ed3\u5408\u7684Pt NPs\u62161 \u03bcmg kg-1<\/sup> ICG\u7ed3\u5408\u7684chem-Pt NPs\u540e1-3 d\u7684\u80bf\u7624NIR\u56fe\u50cf\uff1b<\/p>\n

\uff08c\uff09\u75281 \u03bcmg kg-1<\/sup> ICG\u5076\u8054\u7684Pt NPs\u6cbb\u7597\u539f\u4f4d\u809d\u80bf\u7624\u6a21\u578b\u7684NIR\u56fe\u50cf\u7684\u4e09\u7ef4\u91cd\u5efa\uff1b<\/p>\n

\uff08d\uff09\u539f\u4f4d\u809d\u80bf\u7624\u7684\u89e3\u5256\u4f4d\u7f6e\u548cMIR\u6210\u50cf\uff1b<\/p>\n

\uff08e\uff09\u9759\u8109\u6ce8\u5c041 \u03bcmg kg-1<\/sup> ICG\u7ed3\u5408\u7684Pt NPs\u62161 \u03bcmg kg-1<\/sup>\u767d\u86cb\u767d\u7ed3\u5408\u7d2b\u6749\u9187\uff08Abraxane\uff09-ICG\u6cbb\u7597\u540e1-2\u5929\uff0c\u80bf\u7624\u7684NIR\u56fe\u50cf;<\/p>\n

\uff08f\uff091 mg\/kg ICG\u5076\u8054\u7684Pt NPs\u6cbb\u7597\u540e\u80bf\u7624\u7684NIR\u56fe\u50cf\u7684\u4e09\u7ef4\u91cd\u5efa\u3002<\/p>\n

\u56fe\u516d\u3001Pt NPs\u9006\u8f6c\u80bf\u7624\u7ec6\u80de\u7684DNR\u8010\u836f\u6027<\/strong>
\n \"\"\uff08a\uff09\u7528PBS\u30010.1 \u03bcmg kg-1<\/sup> DNR\u30011\u03bcmg kg-1<\/sup>\u987aPt\u30011 \u03bcmg kg-1<\/sup>\u7684Pt NPs\u7b49\u5904\u7406DNR\u654f\u611f\u548c\u8010DNR\u7684K562\u7ec6\u80de\u8377\u7624\u88f8\u9f20\uff1b<\/p>\n

\uff08b\uff09\u5982\u56fea\u6240\u793a\uff0c\u5904\u7406\u5bf9DNR\u654f\u611f\u548c\u5bf9DNR\u6709\u62b5\u6297\u529b\u7684K562\u7ec6\u80de\u6216HepG2\u7ec6\u80de\uff0c\u5e76\u5904\u7406\u80bf\u7624\u4f53\u79ef\uff1b<\/p>\n

\uff08c\uff09\u5bf9K562\u80bf\u7624\u7ec4\u7ec7\u5207\u7247\u8fdb\u884cTUNEL\u67d3\u8272\uff1b<\/p>\n

\uff08d\uff09\u786e\u5b9a\u51cb\u4ea1\u7ec6\u80de\u7684\u767e\u5206\u6bd4\uff1b<\/p>\n

\uff08e\uff09\u5bf9K562\u80bf\u7624\u88c2\u89e3\u7269\u4e2d\u88c2\u89e3\u7684caspase-3\u3001-8\u548c-9\u7684\u6c34\u5e73\u8fdb\u884c\u86cb\u767d\u8d28\u5370\u8ff9\u5206\u6790\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

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\u6587\u732e\u94fe\u63a5\uff1aBlood-triggered generation of platinum nanoparticle functions as an anti-cancer agent<\/a><\/strong>\uff08Nature Communications<\/em>, 2020<\/strong>, DOI: 10.1038\/s41467-019-14131-z\uff09<\/p>\n

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