{"id":197864,"date":"2020-03-17T06:45:56","date_gmt":"2020-03-16T22:45:56","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=197864"},"modified":"2020-03-16T18:46:26","modified_gmt":"2020-03-16T10:46:26","slug":"%e5%8d%97%e6%b4%8b%e7%90%86%e5%b7%a5%e5%a4%a7%e5%ad%a6%e6%b5%a6%e4%be%83%e8%a3%94%e8%af%be%e9%a2%98%e7%bb%84acc-chem-res-%ef%bc%9a%e5%9f%ba%e4%ba%8e%e5%8d%8a%e5%af%bc%e4%bd%93%e8%81%9a%e5%90%88","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=197864","title":{"rendered":"\u5357\u6d0b\u7406\u5de5\u5927\u5b66\u6d66\u4f83\u88d4\u8bfe\u9898\u7ec4Acc. Chem. Res.\uff1a\u57fa\u4e8e\u534a\u5bfc\u4f53\u805a\u5408\u7269\u7eb3\u7c73\u6750\u6599\u7684\u8fd1\u7ea2\u5916\u5149\u6fc0\u6d3b\u65b0\u578b\u80bf\u7624\u836f\u7269"},"content":{"rendered":"

\u3010\u5f15\u8a00<\/strong>\u3011<\/p>\n

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\u3010\u6210\u679c\u7b80\u4ecb<\/strong>\u3011<\/p>\n

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\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe<\/strong>1.<\/strong>\u57fa\u4e8e<\/strong>SPNs<\/strong>\u7684\u5149\u6fc0\u6d3b\u6cbb\u7597\u5242\u7684\u5236\u5907<\/strong><\/p>\n

\"\"<\/p>\n

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\uff08b\uff09\u901a\u8fc7\u81ea\u7ec4\u88c5\u5236\u5907SPN\u7684\u793a\u610f\u56fe\uff0cSP2-PEG\uff0c\u54cd\u5e94\u6027\u7247\u6bb5\u548c\u6cbb\u7597\u5242\u7684\u5316\u5b66\u7ed3\u6784\u5f0f\u4ee5\u53caSPN2\u7684\u900f\u5c04\u7535\u5b50\u663e\u5fae\u7167\u7247<\/p>\n

\uff08c\uff091<\/sup>O2<\/sub>\u8bf1\u5bfc\u76841<\/sup>O2<\/sub>\u54cd\u5e94\u6027\u7247\u6bb5\u88c2\u89e3\u7684\u673a\u5236<\/p>\n

\u56fe<\/strong>2.<\/strong>\u5149\u70ed\u6d3b\u5316\u534a\u5bfc\u4f53\u805a\u5408\u7269\u7eb3\u7c73\u5174\u594b\u5242\u7528\u4e8e\u764c\u75c7\u7684\u6cbb\u7597<\/strong>\"\"<\/strong><\/p>\n

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\uff08b\uff09SPN1-C\u7684\u5408\u6210<\/p>\n

\uff08c\uff09SPN1-C\u4ecb\u5bfc\u7684TRPV-1 Ca2+<\/sup>\u901a\u9053\u5149\u70ed\u6d3b\u5316\u7684\u673a\u7406<\/p>\n

\uff08d\uff09SPN1-C\u548cSPN1-0\u5904\u7406\u540e\u7ecf808 nm\u5149\u7167\u5c0435 s\u540e\u7684U373\u7ec6\u80de\u548cHeLa\u7ec6\u80de\u7684\u8367\u5149\u56fe\u50cf<\/p>\n

\uff08e\uff09\u8377\u7624\u5c0f\u9f20\u7684\u6cbb\u7597\u65b9\u6848<\/p>\n

\uff08f,g\uff09\u4e0d\u540c\u6cbb\u7597\u65b9\u5f0f\u540eU373\u80bf\u7624\u548cHeLa\u80bf\u7624\u7684\u80bf\u7624\u751f\u957f\u66f2\u7ebf<\/p>\n

\u56fe<\/strong>3.<\/strong>\u5149\u70ed\u53ef\u6d3b\u5316\u534a\u5bfc\u4f53\u805a\u5408\u7269\u7eb3\u7c73\u9176\u7528\u4e8e\u764c\u75c7\u7684\u6cbb\u7597<\/strong><\/p>\n

\"\"<\/p>\n

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\uff08f\uff09\u5c3e\u9759\u8109\u5185\u6ce8\u5c04SPN2\u6216SPN2-Bro\u540e\uff0c\u7ecf808 nm\u5149\u7167\u5c04\u76844T1\u8377\u7624\u5c0f\u9f20\u7684\u8fd1\u7ea2\u5916\u8367\u5149\u56fe\u50cf<\/p>\n

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\u56fe<\/strong>4.<\/strong>\u4e4f\u6c27\u6fc0\u6d3b\u7684\u534a\u5bfc\u4f53\u805a\u5408\u7269\u7eb3\u7c73\u524d\u836f\u7528\u4e8e\u764c\u75c7\u6cbb\u7597<\/strong><\/p>\n

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\uff08a\uff09SPN2pd\u7528\u4e8e\u4e4f\u6c27\u6fc0\u6d3b\u7684\u534f\u540cPDT\u548c\u5316\u7597\u7684\u793a\u610f\u56fe<\/p>\n

\uff08b\uff09\u5728808 nm\u5149\u8f90\u7167\u4e0b\uff0cSPN2pd\u548cSPN2c\u5f15\u53d1\u76841<\/sup>O2<\/sub><\/p>\n

\u751f\u6210<\/p>\n

\uff08c\uff09SPN2pd\u7684\u6d3b\u5316\u548c\u91ca\u653e\u836f\u7269\u7684\u673a\u5236\u793a\u610f\u56fe<\/p>\n

\uff08d\uff09\u6fc0\u6d3b\u540e\u7684NADH\uff0cIPM-Br\u548cSPN2pd\u7684\u9ad8\u6548\u6db2\u76f8\u8272\u8c31\u56fe<\/p>\n

\uff08e,f\uff09\u5728\u5e38\u6c27\u548c\u4e4f\u6c27\u73af\u5883\u4e2d\uff0c\u4e0d\u540c\u6d53\u5ea6\u7684SPN2c\u6216SPN2pd\u5904\u7406\u540e4T1\u764c\u7ec6\u80de\u7684\u7ec6\u80de\u6d3b\u6027<\/p>\n

\uff08g\uff09\u4e0d\u540c\u5904\u7406\u65b9\u5f0f\u540e\u5c0f\u9f20\u80bf\u7624\u7684\u514d\u75ab\u8367\u5149caspase-3\u67d3\u8272\u56fe\u50cf<\/p>\n

\u56fe<\/strong>5.<\/strong>1<\/sup><\/strong>O2<\/sub><\/strong>\u6fc0\u6d3b<\/strong>\u7684\u534a\u5bfc\u4f53\u805a\u5408\u7269\u7eb3\u7c73\u9176\u548c\u7eb3\u7c73\u963b\u6ede\u5242\u7528\u4e8e\u764c\u75c7\u6cbb\u7597<\/strong><\/p>\n

\"\"<\/p>\n

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\uff08b\uff09OSPE\u5149\u6d3b\u5316\u4ecb\u5bfc\u7684\u7ec6\u80de\u5185RNA\u964d\u89e3\u548c\u534f\u540c\u764c\u75c7\u6cbb\u7597\u7684\u673a\u5236<\/p>\n

\uff08c\uff09\u5728\u6709\u6216\u65e0H2<\/sub>O2<\/sub>\u7684\u60c5\u51b5\u4e0b\uff0c\u7ecf808 nm\u5149\u7167\u540eOSPE\u7684\u9176\u6d3b\u6027\u5206\u6790<\/p>\n

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\uff08e\uff09\u4e0d\u540c\u6cbb\u7597\u540e\u5c0f\u9f20\u80bf\u7624\u7684\u514d\u75ab\u8367\u5149\u560c\u5464\u9709\u7d20\u7ed3\u5408\u86cb\u767d\u67d3\u8272\u56fe\u50cf<\/p>\n

\uff08f\uff09\u4e0d\u540c\u6cbb\u7597\u540e\u5c0f\u9f20\u80bf\u7624\u7684\u751f\u957f\u66f2\u7ebf<\/p>\n

\uff08g\uff09\u4e0d\u540c\u5904\u7406\u540e\u5c0f\u9f20\u80ba\u8f6c\u79fb\u7684H\uff06E\u67d3\u8272\u56fe\u50cf<\/p>\n

\uff08h\uff09\u5728SPN2B\u6216SPN2C\u4ecb\u5bfc\u7684\u6cbb\u7597\u540e\uff0c4T1\u8377\u7624\u5c0f\u9f20\u7684\u80bf\u7624\u4e2dHGF\uff0cMTA2\u548cVCAM-1\u8868\u8fbe\u91cf<\/p>\n

\u56fe<\/strong>6<\/strong>.<\/strong>\u6709\u673a\u534a\u5bfc\u4f53\u805a\u5408\u7269\u7eb3\u7c73\u523a\u6fc0\u7269\u7528\u4e8e\u764c\u75c7\u7684\u5149\u6fc0\u6d3b\u514d\u75ab\u6cbb\u7597<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09OSPS\u4ecb\u5bfc\u7684\u514d\u75ab\u6fc0\u6d3b\u7528\u4e8e\u8054\u5408\u764c\u75c7\u6cbb\u7597\u7684\u793a\u610f\u56fe<\/p>\n

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\uff08c\uff09\u7ecf808 nm\u5149\u7167\u5c04\u540eOSPS\u7684HPLC\u56fe\u8c31<\/p>\n

\uff08d\uff09OSPS\u4ecb\u5bfc\u7684\u6291\u5236\u80bf\u7624\u751f\u957f\u53ca\u80ba\u8f6c\u79fb\u7684\u764c\u75c7\u6cbb\u7597\u7684\u793a\u610f\u56fe<\/p>\n

\uff08e\uff09OSPS\u4ecb\u5bfc\u7684NIR\u5149\u6d3b\u5316\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u7684\u603b\u7ed3\u56fe<\/p>\n

\u3010\u603b\u7ed3\u3011<\/strong><\/p>\n

\u5728\u8fd9\u4e2a\u5de5\u4f5c\u4e2d\uff0c\u4f5c\u8005\u603b\u7ed3\u4e86\u8fd1\u671fSPN\u7528\u4e8e\u8fd1\u7ea2\u5916\u5149\u6fc0\u6d3b\u7684\u80bf\u7624\u6cbb\u7597\u5242\u7684\u76f8\u5173\u7814\u7a76\u6210\u679c\u3002SPN\u53ef\u4ee5\u5c06NIR\u5149\u8f6c\u6362\u4e3a\u70ed\u62161<\/sup>O2<\/sub>\uff0c\u4ece\u800c\u5bfc\u81f4\u6cbb\u7597\u5242\u7684\u6d3b\u5316\u3002\u57fa\u4e8eSPN\u7684\u5149\u6fc0\u6d3b\u6cbb\u7597\u836f\u7269\u53ef\u4ee5\u8fdc\u7a0b\u548c\u65e0\u521b\u5730\u6fc0\u6d3b\u7279\u5b9a\u7684\u751f\u7269\u884c\u4e3a\uff0c\u4f8b\u5982Ca2+<\/sup>\u901a\u9053\u7684\u5f00\u542f\uff0cECM\u964d\u89e3\uff0c\u57fa\u56e0\u8f6c\u5f55\uff0cDNA\u635f\u4f24\uff0cRNA\u964d\u89e3\uff0c\u86cb\u767d\u8d28\u751f\u7269\u5408\u6210\u6291\u5236\u6216\u6d3b\u4f53\u52a8\u7269\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u514d\u75ab\u53cd\u5e94\u7684\u6fc0\u6d3b\u3002\u8fd9\u4e9b\u5149\u6d3b\u5316\u7684\u6cbb\u7597\u5242\u53ef\u4ee5\u5b9e\u73b0\u7cbe\u786e\u7684\u764c\u75c7\u6cbb\u7597\uff0c\u56e0\u6b64\u4e0d\u4ec5\u6539\u5584\u4e86\u6cbb\u7597\u6548\u679c\uff0c\u800c\u4e14\u964d\u4f4e\u4e86\u6bd2\u526f\u4f5c\u7528\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5<\/strong>\uff1aSemiconducting Polymer Nanomaterials as Near-Infrared Photoactivatable Protherapeutics for Cancer<\/a>. Acc. Chem. Res., <\/em>2020<\/strong>, DOI: 10.1021\/acs.accounts.9b00569.<\/p>\n

 <\/p>\n

\u901a\u8baf\u4f5c\u8005\u7b80\u4ecb\uff1a<\/h1>\n

\u6d66\u4f83\u88d4\uff0c\u73b0\u4efb\u65b0\u52a0\u5761\u5357\u6d0b\u7406\u5de5\u5927\u5b66\u5316\u5b66\u4e0e\u751f\u7269\u533b\u5b66\u5de5\u7a0b\u5b66\u9662\u526f\u6559\u6388\uff1b2011\u5e74\u4e8e\u65b0\u52a0\u5761\u56fd\u7acb\u5927\u5b66\u83b7\u5f97\u535a\u58eb\u5b66\u4f4d\uff0c\u540c\u5e74\u4f5c\u4e3a\u535a\u58eb\u540e\u52a0\u5165\u65af\u5766\u798f\u5927\u5b66\u4ece\u4e8b\u5206\u5b50\u5f71\u50cf\u5b66\u7814\u7a76\uff0c2015\u5e746\u6708\u4ee5\u526f\u6559\u6388\u53d7\u8058\u4e8e\u5357\u6d0b\u7406\u5de5\u5927\u5b66\u3002<\/p>\n

\u8fd1\u5e74\u6765\uff0c\u6d66\u4f83\u88d4\u6559\u6388\u8bfe\u9898\u7ec4\u4e3b\u8981\u63a2\u7d22\u6709\u673a\u6750\u6599\u5728\u751f\u7269\u533b\u5b66\u5149\u5b50\u5b66\u4e2d\u5e94\u7528\u3002\u76ee\u524d\u4e3b\u8981(i)\u9488\u5bf9\u4e34\u5e8a\u9700\u6c42\u5f00\u53d1\u667a\u80fd\u54cd\u5e94\u578b\u6d3b\u4f53\u8367\u5149\u3001\u81ea\u53d1\u5149\u53ca\u5149\u58f0\u6210\u50cf\u5206\u5b50\u63a2\u9488\u7528\u4e8e\u65e9\u671f\u75be\u75c5\u8bca\u65ad;(ii) \u9488\u5bf9\u57fa\u7840\u751f\u7269\u533b\u5b66\u5f00\u53d1\u57fa\u4e8e\u534a\u5bfc\u4f53\u805a\u5408\u7269(SPN\uff1asemiconducting polymer nanoparticles)\u7684\u7eb3\u7c73\u5149\u5b50\u8f6c\u6362\u5668\u7528\u4e8e\u5728\u5206\u5b50\u5c42\u9762\u8c03\u63a7\u5e76\u4e86\u89e3\u751f\u7269\u8fc7\u7a0b\uff1b(iii)\u7814\u7a76\u6709\u673a\u5149\u5b66\u6750\u6599\u5728\u80bf\u7624\u6cbb\u7597\u4e2d\u7684\u5e94\u7528\u3002\u76ee\u524d\uff0c\u8be5\u8bfe\u9898\u7ec4\u5df2\u5728\u764c\u75c7\u8bca\u7597\u3001\u76ae\u80a4\u75c5\u68c0\u6d4b\u4e0e\u836f\u7269\u6bd2\u6027\u7b5b\u9009\u4e2d\u53d6\u5f97\u521d\u6b65\u8fdb\u5c55\u3002\u4f8b\u5982\uff0c\u57282017\u5e74\u8be5\u8bfe\u9898\u7ec4\u9996\u6b21\u5f00\u521b\u4e86\u57fa\u4e8e\u53ef\u964d\u89e3\u6709\u673a\u9ad8\u5206\u5b50\u7eb3\u7c73\u9897\u7c92\u7684\u5206\u5b50\u4f59\u8f89\u6210\u50cf(MAI: molecular afterglow imaging)\uff0c\u5e76\u63a2\u7d22\u4e86\u5176\u5728\u75be\u75c5\u7684\u65e9\u671f\u8bca\u65ad\u548c\u6cbb\u7597\u65b9\u9762\u7684\u6f5c\u5728\u5e94\u7528\u3002\u8be5\u7814\u7a76\u6210\u679c\u53d1\u8868\u4e8e\u56fd\u9645\u9876\u7ea7\u671f\u520aNature Biotechnology\u3002\u57282019\u5e74\u8be5\u8bfe\u9898\u7ec4\u8bbe\u8ba1\u4e86\u4e00\u79cd\u5177\u6709\u9ad8\u6548\u7684\u80be\u6e05\u9664\u6548\u7387\u7684\u5206\u5b50\u80be\u810f\u63a2\u9488(MRPs: molecular renal probes)\u7528\u4e8e\u5bf9\u836f\u7269\u6027\u6025\u6027\u80be\u635f\u4f24(AKI: acute kidney injury)\u7684\u4f53\u5185\u5149\u5b66\u6210\u50cf\u3002\u8be5\u63a2\u9488\u7684\u8fd1\u7ea2\u5916\u8367\u5149\u6216\u8005\u5316\u5b66\u53d1\u5149\u4fe1\u53f7\u53ef\u4ee5\u88abAKI\u7684\u524d\u671f\u751f\u7269\u6807\u8bb0\u7269\u7279\u5f02\u6027\u5730\u6fc0\u6d3b\uff0c\u4f7f\u5f97\u8be5\u63a2\u9488\u53ef\u4ee5\u5bf9\u5b9e\u9a8c\u5c0f\u9f20\u80be\u810f\u5185\u591a\u4e2a\u5206\u5b50\u4e8b\u4ef6\u8fdb\u884c\u7eb5\u5411\u6210\u50cf\u3002\u8be5\u7814\u7a76\u6210\u679c\u53d1\u8868\u4e8e\u56fd\u9645\u9876\u7ea7\u671f\u520aNature Materials\u3002\u53e6\u5916\uff0c\u91c7\u7528\u8fd1\u7ea2\u5916\u8367\u5149\u548c\u5149\u58f0\u7b49\u6210\u50cf\u6280\u672f\uff0c\u8be5\u7ec4\u5b9e\u73b0\u4e86\u76ae\u80a4\u75c5\u3001\u809d\u635f\u4f24\u4ee5\u53ca\u80bf\u7624\u7b49\u75be\u75c5\u53d1\u5c55\u8fc7\u7a0b\u4e2d\u76f8\u5173\u751f\u7269\u6807\u8bb0\u7269\u7684\u6d3b\u4f53\u68c0\u6d4b\uff0c\u4e3a\u75be\u75c5\u7684\u65e9\u671f\u8bca\u65ad\u63d0\u4f9b\u4e86\u6709\u7528\u4fe1\u606f\u3002\u8be5\u56e2\u961f\u7814\u7a76\u65b9\u5411\u4e5f\u6d89\u53ca\u667a\u80fd\u54cd\u5e94\u578b\u7eb3\u7c73\u533b\u836f\uff0c\u5149\u70ed\u8c03\u63a7\u79bb\u5b50\u901a\u9053\u3001\u57fa\u56e0\u8868\u8fbe\u548c\u86cb\u767d\u6d3b\u6027\u7b49\u76f8\u5173\u7814\u7a76\u3002\u81ea2015\u5e746\u6708\u6210\u7acb\u81f3\u4eca\uff0c\u8be5\u56e2\u961f\u5df2\u5728\u56fd\u9645\u4e3b\u6d41\u671f\u520a\u4e0a\u53d1\u8868\u9ad8\u6c34\u5e73\u6587\u7ae080\u591a\u7bc7\uff08\u5305\u62ecNature Materials, Nature Biotechnology, Nature Communications, Chemical Society Reviews, Accounts of Chemical Research, Journal of the American Chemical Society, Angewandte Chemie International Edition, Advanced Materials, Nano Letters, ACS Nano\u7b49\uff09\u3002\u81f3\u4eca\uff0c\u6d66\u4f83\u88d4\u6559\u6388\u7d2f\u8ba1\u53d1\u8868\u9ad8\u6863\u6b21\u6587\u7ae0160\u591a\u7bc7\uff0cSCI H-index = 65\u3002\u76ee\u524d\uff0c\u6d66\u4f83\u88d4\u535a\u58eb\u62c5\u4efbACS Applied Polymer Materials \u548cBiomaterials Research\u526f\u4e3b\u7f16\uff0cNano Research\u671f\u520aYoung Star\u4e3b\u7f16\uff0cAdvanced Functional Materials, Small, Bioconjugate Chemistry, ACS Applied Bio Materials, Advanced Biosystems\u548cChemNanoMat\u7b49\u671f\u520a\u7f16\u59d4\u3002<\/p>\n

\u8bfe\u9898\u7ec4\u4e3b\u9875\uff1ahttp:\/\/www.ntu.edu.sg\/home\/kypu\/index.html<\/a><\/p>\n

\u00a0<\/strong><\/p>\n

\u8fd1\u671f\u4ee3\u8868\u6027\u5de5\u4f5c\uff1a<\/strong><\/p>\n

    \n
  1. Huang, J. Li, Y. Lyu, Q. Miao, K. Pu*. Molecular optical imaging probes for early diagnosis of drug-induced acute kidney injury. Nat. Mater., 2019, 2019, 18, 1133-1143.<\/li>\n
  2. Miao, C. Xie, X. Zhen, Y. Lyu, H. Duan, X. Liu, J. Jokerst, K Pu*. Molecular afterglow imaging with bright, biodegradable polymer nanoparticles. Nat. Biotechnol., 2017, 35, 1102-1110.<\/li>\n
  3. Jiang, J. Huang, X. Zhen, Z. Zeng, J. Li, C. Xie, Q. Miao, J. Chen, P. Chen, K. Pu*. A generic approach towards afterglow luminescent nanoparticles for ultrasensitive in vivo imaging. Nat. Commun., 2019, 10, 2064.<\/li>\n
  4. Cheng, Q. Miao, J. Li, J. Huang, C. Xie, K. Pu*. J. Am. Chem. Soc., 2019, 141, 27, 10581-10584.<\/li>\n
  5. Li, J. Huang, Y. Lyu, J. Huang, Y. Jiang, C. Xie, K. Pu*. Photoactivatable organic semiconducting pro-nanoenzymes. J. Am. Chem. Soc., 2019, 141, 4073-4079.<\/li>\n
  6. He, C. Xie, Y. Jiang, K. Pu*. An organic afterglow protheranostic nanoassembly. Adv. Mater., 2019, 31, 1902672.<\/li>\n
  7. Jiang, J. Li, Z. Zeng, C. Xie, Y. Lyu, K. Pu*. Organic photodynamic nanoinhibitor for synergistic cancer therapy. Angew. Chem., Int. Ed., 2019, 58, 8161-8165.<\/li>\n
  8. Cui, J. Huang, X. Zhen, J. Li, Y. Jiang, K. Pu*. Semiconducting polymer nano-prodrug for hypoxia-activated synergetic photodynamic cancer therapy. Angew. Chem., Int. Ed., 2019, 58, 5920-5924.<\/li>\n
  9. Huang, Y. Jiang, J. Li, S. He, J. Huang, K. Pu*. A Renal-clearable macromolecular reporter for near-infrared fluorescence imaging of bladder cancer. Angew. Chem., Int. Ed., 2020, 59, 4415-4420.<\/li>\n
  10. Jiang, P. Upputuri, C. Xie, Z. Zeng, A. Sharma, X. Zhen, J. Li, J. Huang, M. Pramanik, K. Pu*. Metabolizable semiconducting polymer nanoparticles for second near-infrared photoacoustic imaging. Adv. Mater., 2019, 31, 1808166.<\/li>\n
  11. Li, K. Pu*. Development of organic semiconducting materials for deep-tissue optical imaging, phototherapy and photoactivation. Chem. Soc. Rev., 2019, 48, 38-71.<\/li>\n<\/ol>\n

    \u00a0<\/em><\/p>\n

    \u672c\u6587\u7531tt\u4f9b\u7a3f\u3002\u00a0<\/p>\n

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