{"id":197906,"date":"2020-03-13T06:26:23","date_gmt":"2020-03-12T22:26:23","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=197906"},"modified":"2020-03-12T21:26:43","modified_gmt":"2020-03-12T13:26:43","slug":"%e9%9d%a2%e5%af%b9%e7%96%ab%e6%83%85%ef%bc%8c%e6%88%91%e4%bb%ac%e6%9d%90%e6%96%99%e4%ba%ba%e5%8f%af%e4%bb%a5%e5%81%9a%e4%bb%80%e4%b9%88-%e6%8a%97%e7%97%85%e6%af%92%e7%ba%b3%e7%b1%b3","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=197906","title":{"rendered":"\u9762\u5bf9\u75ab\u60c5\uff0c\u6211\u4eec\u6750\u6599\u4eba\u53ef\u4ee5\u505a\u4ec0\u4e48\u2014\u2014\u6297\u75c5\u6bd2\u7eb3\u7c73\u6750\u6599\u5c06\u4e0e\u75c5\u6bd2\u6597\u4e89\u5230\u5e95\uff01"},"content":{"rendered":"

1 <\/b><\/strong>\u524d\u8a00<\/b><\/strong><\/p>\n

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\u56fe<\/b><\/strong>1<\/b><\/strong>\u00a0\u5404\u7c7b\u75c5\u6bd2\u7684\u7535\u955c\u56fe\u3002\uff08\u6709\u7684\u56fe\u4e0a\u4e86\u4f2a\u5f69\uff0c\u56fe\u7247\u6765\u6e90\u5404\u5927\u7f51\u7ad9\uff09<\/strong><\/p>\n

\"\"<\/p>\n

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2 \u6297\u75c5\u6bd2\u7eb3\u7c73\u6750\u6599\u7684\u7814\u53d1\u6f5c\u529b\u5728\u54ea\u91cc\uff1f<\/b><\/strong><\/p>\n

\"\"<\/p>\n

3<\/b><\/strong>\u00a0<\/b><\/strong>\u6297\u75c5\u6bd2\u836f\u7269\u7684\u7eb3\u7c73\u8f7d\u4f53\u6750\u6599<\/b><\/strong><\/p>\n

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\"\"<\/p>\n

4<\/b><\/strong>\u00a0<\/b><\/strong>\u6297\u75c5\u6bd2\u7eb3\u7c73\u6750\u6599<\/b><\/strong><\/p>\n

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a.\u91d1\u5c5e\u7eb3\u7c73\u6750\u6599<\/b><\/strong><\/p>\n

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\u88681. \u90e8\u5206\u6297\u75c5\u6bd2\u7eb3\u7c73\u7c92\u5b50\u4ee5\u53ca\u6297\u75c5\u6bd2\u6848\u4f8b\uff0c\u5177\u4f53\u89c1\u6587\u732e\u00a0[3-4]<\/sup><\/strong><\/p>\n

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\"\"<\/p>\n

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b.\u975e\u91d1\u5c5e\u7eb3\u7c73\u6750\u6599<\/b><\/strong><\/p>\n

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\u5bcc\u52d2\u70ef\u53ca\u5176\u884d\u751f\u7269<\/i><\/b><\/em><\/strong><\/p>\n

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\u6297\u75c5\u6bd2\u673a\u74061\uff1a\u6291\u5236\u75c5\u6bd2\u5185\u90e8\u9176\u7684\u6d3b\u6027<\/p>\n

\u5b9e\u9a8c\u5bf9\u8c61\uff1aHIV\u75c5\u6bd2\u2014\u2014\u5bcc\u52d2\u70ef\u5bf9HIV\u75c5\u6bd2\u86cb\u767d\u9176\uff08HIVP\uff09\u6709\u6291\u5236\u4f5c\u7528\uff0cHIVP\u662f\u5bcc\u52d2\u70ef\u6297\u75c5\u6bd2\u7684\u4e3b\u8981\u9776\u70b9\uff0c\u6291\u5236\u5176\u6d3b\u6027\u5c31\u53ef\u4ee5\u7ec8\u6b62HIV\u7684\u751f\u547d\u5468\u671f[5]<\/sup>\u3002<\/p>\n

\u6297\u75c5\u6bd2\u673a\u74062\uff1a\u963b\u65ad\u5bbf\u4e3b\u7ec6\u80de\u8868\u9762\u53d7\u4f53<\/p>\n

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\u56fe3 <\/strong><\/p>\n

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a\u3001\u5341\u4e09\u78b3\u5bcc\u52d2\u70ef\uff0817a-c\uff09\u7684\u5408\u6210\u65b9\u6848\u3002b\u3001\u5341\u4e09\u78b3\u5bcc\u52d2\u70ef\uff0817a-c\uff09\u7684\u751f\u7269\u5b66\u7814\u7a76[6]<\/sup>\u3002<\/p>\n

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\u56fe<\/b><\/strong>4 <\/b>GO\u6297\u75c5\u6bd2\u4f5c\u7528\u7684\u53ef\u80fd\u673a\u5236\u793a\u610f\u56fe\u3002<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09\u6b63\u5e38\u75c5\u6bd2\u901a\u8fc7\u4e0e\u7ec6\u80de\u53d7\u4f53\u76f8\u4e92\u4f5c\u7528\u800c\u88ab\u7ec6\u80de\u5438\u6536\uff0c\u4ece\u800c\u5f15\u53d1\u611f\u67d3\u3002\uff08b\uff09\u5e26\u8d1f\u7535\u7684GO\u6709\u66f4\u591a\u673a\u4f1a\u4e0e\u5e26\u6b63\u7535\u7684\u75c5\u6bd2\u76f8\u4e92\u4f5c\u7528\uff0c\u4ece\u800c\u5bfc\u81f4\u75c5\u6bd2\u635f\u574f\u548c\u611f\u67d3\u6291\u5236\u3002\uff08c\uff09GO\u4e0e\u975e\u79bb\u5b50\u578b\u805a\u4e59\u70ef\u5421\u54af\u70f7\u916e\uff08PVP\uff09\u5171\u8f6d\uff0c\u53ef\u4f7f\u611f\u67d3\u88ab\u963b\u65ad\u3002\uff08d\uff09GO\u4e0e\u9633\u79bb\u5b50\u578b\u805a\u4e8c\u70ef\u4e19\u57fa\u4e8c\u7532\u57fa\u6c2f\u5316\u94f5\uff08PDDA\uff09\u5171\u8f6d\u5219\u65e0\u6cd5\u963b\u6b62\u75c5\u6bd2\u611f\u67d3\u7ec6\u80de[7]<\/sup>\u3002<\/p>\n

5<\/b><\/strong>\u00a0<\/b><\/strong>\u6297\u75c5\u6bd2\u7eb3\u7c73\u6750\u6599\u4f5c\u4e3a\u5e7f\u8c31\u6297\u75c5\u6bd2\u836f\u7269\u7684\u8fdb\u5c55<\/b><\/strong><\/p>\n

\u73b0\u6709\u7684\u6297\u75c5\u6bd2\u836f\u7269\u5f80\u5f80\u53ea\u80fd\u9488\u5bf9\u5355\u4e00\u7684\u6216\u8005\u67d0\u4e00\u7c7b\u75c5\u6bd2\uff0c\u800c\u4e14\u9700\u8981\u6301\u7eed\u670d\u7528\u6765\u62b5\u6297\u75c5\u6bd2\uff0c\u4f46\u662f\u75c5\u6bd2\u5bb9\u6613\u53d8\u5f02\uff0c\u4e00\u65e6\u6210\u719f\u540e\u5bfc\u81f4\u7684\u6297\u836f\u6027\u53cd\u800c\u4f1a\u5bfc\u81f4\u4e25\u91cd\u7684\u98ce\u9669\u3002\u56e0\u6b64\u7814\u7a76\u51fa\u5e7f\u8c31\u578b\u6297\u75c5\u6bd2\u7eb3\u7c73\u9897\u7c92\u8feb\u5728\u7709\u776b\u3002\u76ee\u524d\u5df2\u6709\u4e00\u4e9b\u8fdb\u5c55\u3002<\/p>\n

a. \u6297\u75c5\u6bd2\u79cd\u7c7b\uff1a<\/i><\/em><\/i>\u5355\u7eaf\u75b1\u72b6\u75c5\u6bd2\u3001\u4eba\u4e73\u5934\u7624\u75c5\u6bd2\u3001\u547c\u5438\u9053\u5408\u80de\u75c5\u6bd2\u3001\u767b\u9769\u70ed\u75c5\u6bd2\u3001\u6162\u75c5\u6bd2<\/i><\/em><\/p>\n

2017\u5e74\uff0c\u4e00\u4e2a\u7531\u7f8e\u56fd\u3001\u65b0\u897f\u5170\u3001\u610f\u5927\u5229\u7b49\u56fd\u79d1\u5b66\u5bb6\u7ec4\u6210\u7684\u56fd\u9645\u8bfe\u9898\u7ec4\u8bbe\u8ba1\u4e86\u4e00\u79cd\u65b0\u578b\u7684\u6297\u75c5\u6bd2\u7eb3\u7c73\u9897\u7c92\uff0c\u53ef\u4ee5\u5e7f\u8c31\u7684\u9488\u5bf9\u6740\u6b7b\u5404\u79cd\u75c5\u6bd2\uff0c\u540c\u65f6\u5bf9\u4e8e\u6b63\u5e38\u7ec4\u7ec7\u7ec6\u80de\u6ca1\u6709\u4f24\u5bb3\u3002\u8be5\u7eb3\u7c73\u9897\u7c92\u7684\u6297\u75c5\u6bd2\u673a\u7406\u5c31\u5728\u4e8e\u53ef\u4ee5\u6a21\u62df\u7ec6\u80de\u8868\u9762\u7684\u786b\u9178\u4e59\u9170\u809d\u7d20\u86cb\u767d\u591a\u7cd6\u5206\u5b50\uff0c\u963b\u65ad\u591a\u6570\u75c5\u6bd2\u4e0e\u5bbf\u4e3b\u7ec6\u80de\u7684\u7ed3\u5408\u3002\u8be5\u6210\u679c\u53d1\u8868\u4e8eNature Materials\u00a0[8]<\/sup>\u3002\u8fd9\u4e00\u5de5\u4f5c\u53ea\u662f\u4e00\u4e2a\u9488\u5bf9\u5168\u7403\u591a\u75c5\u6bd2\u611f\u67d3\u7684\u6cbb\u7597\u65b9\u9762\u7684\u8d77\u6b65\uff0c\u8fd8\u9700\u8981\u540e\u671f\u6df1\u5165\u7684\u4f53\u5185\u5b9e\u9a8c\u3002<\/p>\n

b. \u6297\u75c5\u6bd2\u79cd\u7c7b\uff1a\u5355\u7eaf\u75b1\u75b9\u75c5\u6bd2\u3001\u547c\u5438\u9053\u5408\u80de\u75c5\u6bd2\u3001\u4e19\u578b\u809d\u708e\u75c5\u6bd2\u3001\u827e\u6ecb\u75c5\u6bd2\u3001\u585e\u5361\u75c5\u6bd2\u7b49<\/i><\/em><\/p>\n

\u4eca\u5e74\u4e00\u6708\u4efd\uff0c\u82f1\u56fd\u66fc\u5f7b\u65af\u7279\u5927\u5b66\u9886\u5bfc\u7684\u4e00\u4e2a\u56fd\u9645\u7814\u7a76\u5c0f\u7ec4\u5229\u7528\u5929\u7136\u8461\u8404\u7cd6\u884d\u751f\u7269\u73af\u7cca\u7cbe\u5f00\u53d1\u51fa\u4e00\u79cd\u65b0\u7684\u6297\u75c5\u6bd2\u836f\u7269\u3002\u76f8\u5173\u6210\u679c\u53d1\u8868\u5728science\u5b50\u520a\u4e0a[9]<\/sup>\u3002\u6297\u75c5\u6bd2\u673a\u7406\u540c\u6837\u4e5f\u662f\u6a21\u62df\u7ec6\u80de\u8868\u9762\u7cd6\u8d1f\u8d23\u6700\u521d\u7684\u75c5\u6bd2\u9644\u7740\uff0c\u5982\u786b\u9178\u4e59\u9170\u809d\u7d20\u3002<\/p>\n

c. \u53ef\u62b5\u6297\u591a\u79cd\u5f02\u578b\u6d41\u611f\u75c5\u6bd2<\/i><\/em><\/i>\uff08\u56fe5\uff09<\/p>\n

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\u56fe5 \u80ba\u8868\u9762\u6d3b\u6027\u5242\u4eff\u751f\u8102\u8d28\u4f53\u00a0(PS-GAMP) \u4ecb\u5bfc\u7684\u4f50\u5242\u6d3b\u6027\u3002<\/strong><\/p>\n

\"\"<\/p>\n

\u5728\u80ba\u6ce1\u4e2d\uff0cPS-GAMP\u4e0e\u8868\u9762\u86cb\u767d-A (SP-A) \u6216\u8868\u9762\u86cb\u767d-D (SP-D) \u7ed3\u5408\u5e76\u51ed\u501f\u5176\u4ecb\u5bfc\u7684\u5185\u541e\u4f5c\u7528\u8fdb\u5165\u80ba\u6ce1\u5de8\u566c\u7ec6\u80de\u00a0(AMs)\u3002PS-GAMP\u4e2d\u76842′,3′-\u73af\u9e1f\u82f7\u4e00\u78f7\u9178-\u817a\u82f7\u4e00\u78f7\u9178\uff08cGAMP\uff09\u968f\u540e\u88ab\u91ca\u653e\u5230\u7ec6\u80de\u8d28\u4e2d\uff0c\u5e76\u901a\u8fc7\u7f1d\u9699\u8fde\u63a5\u6d41\u5165\u80ba\u6ce1\u4e0a\u76ae\u7ec6\u80de\u00a0(AECs)\uff0c\u7136\u540e\u6fc0\u6d3b\u8fd9\u4e9b\u7ec6\u80de\u4e2d\u7684\u5e72\u6270\u7d20\u57fa\u56e0\u523a\u6fc0\u7269\u00a0(STING) \u4fe1\u53f7\u901a\u8def\uff0c\u8bf1\u5bfc\u4ea7\u751f\u5927\u91cf\u76841\u578b\u514d\u75ab\u4ecb\u8d28\u3002\u8fd9\u4e9b\u4ecb\u8d28\u4fc3\u8fdb\u4e86CD11b+<\/sup>\u00a0<\/sup>\u6811\u7a81\u72b6\u7ec6\u80de\u7684\u52df\u96c6\u548c\u5206\u5316\uff0c\u8fdb\u800c\u4ecb\u5bfc\u6297\u75c5\u6bd2CD8+<\/sup>\u00a0T\u7ec6\u80de\u548c\u4f53\u6db2\u514d\u75ab\u5e94\u7b54\u3002[10]<\/sup><\/p>\n

6<\/b><\/strong>\u00a0<\/b><\/strong>\u7ed3\u8bed<\/b><\/strong><\/p>\n

\u6b66\u6c49\u5c01\u57ce\uff0c\u53e3\u7f69\u6210\u4e3a\u7545\u9500\u54c1\uff0c\u5b66\u751f\u5f00\u5b66\u3001\u5de5\u4eba\u590d\u5de5\u5ef6\u671f\uff0c\u5927\u591a\u6570\u4eba\u4e5f\u8bb8\u662f\u7ecf\u5386\u4e86\u6709\u751f\u4ee5\u6765\u6700\u957f\u7684\u4e00\u6b21\u5047\u671f\u3002\u8fd9\u6b21\u7684\u65b0\u51a0\u75c5\u6bd2\u4e0d\u662f\u6211\u4eec\u7b2c\u4e00\u6b21\u9762\u5bf9\u7684\u53ef\u6015\u75c5\u6bd2\uff0c\u4e5f\u4e00\u5b9a\u4e0d\u662f\u6211\u4eec\u6700\u540e\u9762\u5bf9\u7684\u75c5\u6bd2\u3002\u75c5\u6bd2\u57fa\u56e0\u5bb9\u6613\u53d8\u5f02\uff0c\u6297\u75c5\u6bd2\u836f\u7269\u7684\u7814\u53d1\u5fc5\u7136\u662f\u4e00\u4e2a\u76f8\u5f53\u8270\u96be\u53c8\u6f2b\u957f\u7684\u8fc7\u7a0b\u3002\u8fd9\u6b21\u75ab\u60c5\u8ba9\u6211\u4eec\u610f\u8bc6\u5230\u5728\u75c5\u6bd2\u7814\u7a76\u65b9\u9762\u77e5\u8bc6\u50a8\u5907\u975e\u5e38\u5355\u8584\uff0c\u6211\u4eec\u5bf9\u4e8e\u4f20\u67d3\u6027\u75be\u75c5\u7684\u91cd\u89c6\u7a0b\u5ea6\u8fd8\u662f\u4e0d\u591f\u3002\u4efb\u4f55\u804c\u4e1a\u65b9\u5411\u5176\u5b9e\u90fd\u662f\u76f8\u8f85\u76f8\u6210\u7684\uff0c\u4e0d\u7ba1\u662f\u533b\u5b66\u79d1\u7814\u4eba\u5458\uff0c\u8fd8\u662f\u6750\u6599\u7eb3\u7c73\u6280\u672f\u79d1\u7814\u4eba\u5458\uff0c\u53ea\u8981\u6211\u4eec\u9f50\u5fc3\u534f\u529b\uff0c\u76f8\u4fe1\u5728\u672a\u6765\u5c06\u4f1a\u6709\u66f4\u591a\u7684\u7eb3\u7c73\u6750\u6599\u4f5c\u4e3a\u6297\u75c5\u6bd2\u836f\u7269\u7684\u76f8\u5173\u7814\u7a76\u3002\u9632\u60a3\u4e8e\u672a\u7136\uff0c\u8fd9\u6837\u5728\u4eba\u7c7b\u9762\u4e34\u4e0b\u4e00\u6b21\u75c5\u6bd2\u7206\u53d1\u65f6\uff0c\u4e5f\u8bb8\u4f1a\u6709\u66f4\u591a\u7684\u9884\u9632\u63aa\u65bd\u548c\u6cbb\u7597\u624b\u6bb5\uff0c\u5c06\u635f\u5bb3\u964d\u5230\u6700\u4f4e\u3002\u6700\u540e\u501f\u4ee5\u6b64\u6587\u5e0c\u671b\u6b64\u6b21\u75ab\u60c5\u65e9\u65e5\u6d88\u6563\uff0c\u52a0\u6cb9\uff0c\u4e2d\u56fd\uff01<\/p>\n

\u53c2\u8003\u6587\u732e<\/b><\/strong><\/p>\n

[1] Bowman M C, Ballard T E, Ackerson C J, et al. Inhibition of HIV Fusion with Multivalent Gold Nanoparticles[J]. Journal of the American Chemical Society, 2008, 130(22):6896-6897.<\/p>\n

[2] Cao\u00a0<\/sup>S, Slack\u00a0<\/sup>S, Levy C, et al.\u00a0<\/b><\/strong>Hybrid nanocarriers incorporating mechanistically distinct drugs for lymphatic CD4+<\/sup>\u00a0T cell activation and HIV-1 latency reversal.[J]. Science advances, 2019, 3, eaav6322.<\/p>\n

[3] Galdiero S, Falanga A, Vitiello M, et al. Silver Nanoparticles as Potential Antiviral Agents[J]. Molecules, 2011, 16(10):8894-8918.<\/p>\n

[4] Rai M, Deshmukh S D, Ingle A P, et al. Metal nanoparticles: The protective nanoshield against virus infection[J]. Critical Reviews in Microbiology, 2016,\u00a042(1): 46-56.<\/p>\n

[5]\u00a0Friedman S H, Decamp D L, Sijbesma R P, et al. Inhibition of the HIV-1 protease by fullerene derivatives: model building studies and experimental verification[J]. Journal of the American Chemical Society, 1993, 115(15):6506-6509.<\/p>\n

[6] Antonio Mu\u00f1oz, Sigwalt D, Illescas B M, et al. Synthesis of Giant Globular Multivalent Glycofullerenes as Potent Inhibitors in a Model of Ebola Virus Infection[J]. Nature Chemistry, 2016, 8, 50-57.<\/p>\n

[7]\u00a0Ye S, Shao K, Li Z, et al. Antiviral Activity of Graphene Oxide: How Sharp Edged Structure and Charge Matter[J]. ACS Applied Materials & Interfaces, 2015, 7(38):21571-21579.\u00a0<\/p>\n

[8] Cagno V, Andreozzi P, D\u2019Alicarnasso M, et al. Broad-spectrum non-toxic antiviral nanoparticles with a virucidal inhibition mechanism[J]. Nature Materials, 2017, 17,\u00a0195-203.<\/p>\n

[9]\u00a0Jones S, Cagno V, Jane\u010dek M, et al. Modified cyclodextrins as broad-spectrum antivirals [J]. Science Advances, 2020, 6:eaax9318.<\/p>\n

[10] Wang J, Li P, Yu Y, et al. Pulmonary surfactant-biomimetic nanoparticles potentiate heterosubtypic influenza immunity[J]. Science, 2020, 367, eaau0810.<\/p>\n

\u672c\u6587\u7531\u6768\u4e66\u51dd\u4f9b\u7a3f\u3002<\/p>\n

\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1: tougao@cailiaoren.com.<\/p>\n

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