{"id":198310,"date":"2020-03-31T06:18:18","date_gmt":"2020-03-30T22:18:18","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=198310"},"modified":"2020-03-30T22:19:23","modified_gmt":"2020-03-30T14:19:23","slug":"%e3%80%90%e5%b7%b2%e6%a0%a1%e7%a8%bf%e3%80%91%e9%99%88%e5%ad%a6%e6%80%9d%e5%ae%8b%e4%b8%87%e9%80%9anano-lett-%ef%bc%9a%e5%9f%ba%e4%ba%8e%e8%82%bf%e7%98%a4%e7%89%b9%e5%bc%82%e6%80%a7%e6%b0%a7","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=198310","title":{"rendered":"\u9648\u5b66\u601d&\u5b8b\u4e07\u901aNano Lett.\uff1a\u57fa\u4e8e\u80bf\u7624\u7279\u5f02\u6027\u6c27\u5316\u5e94\u6fc0\u589e\u5f3a\u6297\u80bf\u7624\u514d\u75ab\u7684\u9ad8\u5206\u5b50\u5076\u8054\u7269"},"content":{"rendered":"

\u3010\u7814\u7a76\u80cc\u666f\u3011<\/strong><\/p>\n

\u80bf\u7624\u4e0e\u514d\u75ab\u7ec6\u80de\u4e4b\u95f4\u7684\u4e32\u6270\u5728\u80bf\u7624\u8fdb\u5c55\u548c\u514d\u75ab\u76d1\u6d4b\u4e2d\u8d77\u7740\u91cd\u8981\u4f5c\u7528\u3002\u514d\u75ab\u7ec6\u80de\u5982\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de\uff08TAM\uff09\u5206\u6ccc\u591a\u79cd\u751f\u957f\u56e0\u5b50\u548c\u7ec6\u80de\u56e0\u5b50\u4fc3\u8fdb\u80bf\u7624\u7ec6\u80de\u589e\u6b96\uff0c\u4fc3\u8fdb\u7ec6\u80de\u6269\u6563\uff0c\u523a\u6fc0\u8840\u7ba1\u751f\u957f\u548c\u8840\u7ba1\u751f\u6210\uff1b\u540c\u65f6\uff0c\u80bf\u7624\u7ec6\u80de\u4e5f\u5206\u6ccc\u7ec6\u80de\u56e0\u5b50\uff0c\u5c06\u514d\u75ab\u7ec6\u80de\u7684\u514d\u75ab\u8868\u578b\u8c03\u8282\u4e3a\u514d\u75ab\u6291\u5236\u578b\uff0c\u589e\u5f3a\u514d\u75ab\u8d1f\u6027\u8c03\u8282\u5206\u5b50\u7684\u8868\u8fbe\uff0c\u9632\u6b62\u514d\u75ab\u7ec6\u80de\u7684\u6740\u4f24\u3002\u6700\u8fd1\u7684\u7814\u7a76\u53d1\u73b0\uff0c\u67d0\u4e9b\u6cbb\u7597\u8bf1\u5bfc\u7684\u7ec6\u80de\u6b7b\u4ea1\u4f1a\u5f15\u53d1\u80bf\u7624\u7ec6\u80de\u7279\u5f02\u6027\u7684\u6297\u80bf\u7624\u514d\u75ab\u529b\uff0c\u8fd9\u53ef\u80fd\u662f\u8bb8\u591a\u6210\u529f\u7684\u6297\u764c\u5e72\u9884\u63aa\u65bd\u7684\u91cd\u8981\u539f\u56e0\u4e4b\u4e00\u3002\u8fd9\u79cd\u514d\u75ab\u539f\u6027\u7ec6\u80de\u6b7b\u4ea1\uff08ICD\uff09\u901a\u5e38\u662f\u6cbb\u7597\u8bf1\u5bfc\u7684\u5e7f\u6cdb\u7ec6\u80de\u5e94\u6fc0\u7684\u7ed3\u679c\uff0c\u5176\u7279\u5f81\u662f\u4e3b\u52a8\u6216\u88ab\u52a8\u91ca\u653e\u7ec6\u80de\u6b7b\u4ea1\u76f8\u5173\u5206\u5b50\u6a21\u5f0f\uff08DAMPs\uff09\u3002 \u80bf\u7624\u6d78\u6da6\u6027\u6297\u539f\u63d0\u5448\u7ec6\u80de\u4e0a\u7684\u6a21\u5f0f\u8bc6\u522b\u53d7\u4f53\uff08PRRs\uff09\u53ef\u4ee5\u611f\u53d7\u5230\u8fd9\u4e9b\u963b\u5c3c\uff0c\u5e76\u6fc0\u6d3b\u514d\u75ab\u7cfb\u7edf\u4ee5\u6e05\u9664\u80bf\u7624\u7279\u5f02\u6027\u514d\u75ab\u3002\u5982\u679c\u53ef\u4ee5\u5728\u80bf\u7624\u5185\u90e8\u9009\u62e9\u6027\u5730\u589e\u5f3aICD\u6548\u5e94\uff0c\u5219\u53ef\u4ee5\u901a\u8fc7\u514d\u75ab\u76d1\u89c6\u7684\u6062\u590d\u6765\u6291\u5236\u80bf\u7624\u7684\u751f\u957f\uff0c\u5e76\u4e14\u53ef\u4ee5\u5b9e\u73b0\u957f\u671f\u6291\u5236\u4ee5\u6fc0\u6d3b\u80bf\u7624\u7279\u5f02\u6027\u6297\u80bf\u7624\u514d\u75ab\u529b\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u4e2d\u79d1\u9662\u957f\u6625\u5e94\u5316\u6240\u9648\u5b66\u601d\u9662\u58eb\u3001\u5b8b\u4e07\u901a\u526f\u7814\u7a76\u5458<\/strong>\u7b49\u4eba\u62a5\u9053\u4e86\u4e00\u79cd\u5408\u7406\u8bbe\u8ba1\u7684\u80bf\u7624\u7279\u5f02\u6027\u589e\u5f3a\u6c27\u5316\u5e94\u6fc0\u805a\u5408\u7269\u5076\u8054\u7269\uff08TSEOP\uff09\u4ee5\u589e\u5f3a\u6297\u80bf\u7624\u514d\u75ab\u529b\u3002\u901a\u8fc7\u8089\u6842\u919b\uff08CA\uff09\u30014-\u7532\u9170\u82ef\u787c\u9178\u9891\u54ea\u9187\u916f\u548c5-\u5f02\u6c30\u620a\u70ef-1-\u7094\u7684Passerini\u53cd\u5e94\uff0c\u518d\u4e0e\u805a\uff08L-\u8c37\u6c28\u9178\uff09-\u63a5\u679d\u805a\uff08\u4e59\u4e8c\u9187\uff09\u5355\u7532\u919a\uff08PLG-g<\/em>-mPEG\uff09\u8fdb\u884c\u53e0\u6c2e-\u7094\u70b9\u51fb\u53cd\u5e94\u5236\u5907TSEOP\u3002\u5728\u80bf\u7624\u523a\u6fc0\u6761\u4ef6\u4e0b\uff0cCA\u548c\u918c\u7532\u5316\u5408\u7269\uff08QM\uff09\u8fc5\u901f\u751f\u6210\uff0c\u534f\u540c\u8bf1\u5bfc\u589e\u5f3a\u6c27\u5316\u5e94\u6fc0\u548c\u5185\u8d28\u7f51\u538b\u529b\u3001\u514d\u75ab\u539f\u6027\u80bf\u7624\u7ec6\u80de\u6b7b\u4ea1\uff08ICD\uff09\u548c\u6297\u539f\u63d0\u5448\u7ec6\u80de\u6d3b\u5316\u3002\u4f53\u5185\u7814\u7a76\u8868\u660e\uff0cTSEOP\u6cbb\u7597\u53ef\u589e\u5f3a\u80bf\u7624\u7279\u5f02\u6027\u6297\u80bf\u7624\u514d\u75ab\uff0c\u5e76\u6839\u9664\u5c0f\u9f20\u5927\u80a0\u548c\u4e73\u817a\u80bf\u7624\u3002\u8fd9\u9879\u7814\u7a76\u5bf9\u4e8e\u8bbe\u8ba1\u805a\u5408\u7269\u4f5c\u4e3a\u764c\u75c7\u6cbb\u7597\u7684\u514d\u75ab\u7597\u6cd5\u5177\u6709\u4e00\u5b9a\u7684\u542f\u53d1\u610f\u4e49\u3002\u8be5\u6587\u7ae0\u8fd1\u65e5\u4ee5\u9898\u4e3a\u201cRationally Designed Polymer Conjugate for Tumor-Specific Amplification of Oxidative Stress and Boosting Antitumor Immunity<\/strong>\u201d\u53d1\u8868\u5728\u77e5\u540d\u671f\u520aNano Letters<\/strong>\u4e0a\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe\u4e00\u3001<\/strong>TSEOP<\/strong>\u8bf1\u5bfc<\/strong>ICD<\/strong>\u548c\u589e\u5f3a\u6297\u80bf\u7624\u514d\u75ab\u529b<\/strong><\/p>\n

\"\"<\/p>\n

\u56fe\u4e8c\u3001<\/strong>TSEOP<\/strong>\u7684\u5408\u6210\u9014\u5f84\u4ee5\u53ca<\/strong>CA<\/strong>\u548c<\/strong>QM<\/strong>\u7684\u523a\u6fc0\u54cd\u5e94\u91ca\u653e<\/strong><\/p>\n

\"\"<\/p>\n

\uff08A\uff09 TSEOP\u7684\u5408\u6210\u8def\u7ebf\u3002<\/p>\n

\uff08B\uff09 \u572825\u2103\uff0c100 mM H2<\/sub>O2<\/sub>\u6761\u4ef6\u4e0b\uff0c\u75281<\/sup>H NMR\u6cd5\u6d4b\u8bd5PBCA\u5bf9 H2<\/sub>O2<\/sub>\u7684\u54cd\u5e94\u89e3\u79bb\u4ea7\u751fCA\u548cQM\uff08\u8fc5\u901f\u8f6c\u53d8\u4e3a4-\u7f9f\u57fa\u82c4\u9187\uff09\u3002<\/p>\n

\uff08C\uff09\u5728\u4e0d\u540c\u6761\u4ef6\u4e0b\uff0cTSEOP\u91ca\u653e\u4ea7\u751fCA\u7684\u4f53\u5916\u91ca\u653e\u66f2\u7ebf\u3002<\/p>\n

\u56fe\u4e09\u3001<\/strong>TSEOP<\/strong>\u4f53\u5916\u8bf1\u5bfc\u80bf\u7624\u7ec6\u80de\u6c27\u5316\u5e94\u6fc0\u548c<\/strong>ICD<\/strong><\/p>\n

\"\"<\/p>\n

\uff08A\uff09CLSM\u89c2\u5bdf50 \u03bcMCA\u6d53\u5ea6\u4e0bPBS\u3001CA\u3001P-CA\u3001TSEOP\u5904\u7406CT26\u7ec6\u80de24\u5c0f\u65f6\u540e\u7ec6\u80de\u5185\u7684ROS\u6c34\u5e73\u3002<\/p>\n

\uff08B\uff09\u7ec6\u80de\u5185\u6d3b\u6027\u6c27\u751f\u6210\u7684\u76f8\u5bf9\u5b9a\u91cf\u3002<\/p>\n

\uff08C\uff09CT26\u7ec6\u80de\u672a\u5904\u7406\u548c\u7ecf50 \u03bcM\u7684\u6e38\u79bbCA\u3001P-CA\u3001TSEOP\u5904\u740624\u5c0f\u65f6\u540e\u7684GSH\u6c34\u5e73\u3002<\/p>\n

\uff08D\uff09CT26\u7ec6\u80de\u672a\u5904\u7406\u548c\u7ecfPBA\u6d53\u5ea6\u4e3a50 \u03bcM\u7684\u6e38\u79bbPBA\u6216P-PBA\u5904\u740624\u5c0f\u65f6\u540e\u7684\u7ec6\u80deGSH\u6c34\u5e73\u3002<\/p>\n

\uff08E\uff09\u4e0d\u540cCA\u6d53\u5ea6\u7684CA\u3001P-CA\u548cTSEOP\u5bf9CT26\u7ec6\u80de\u4f53\u5916\u57f9\u517b24\u5c0f\u65f6\u7684\u7ec6\u80de\u6bd2\u6027\u3002<\/p>\n

\uff08F\uff09\u4e0d\u540cCA\u6d53\u5ea6\u7684CA\u3001P-CA\u548cTSEOP\u5bf9NIH-3T3\u7ec6\u80de\u4f53\u5916\u57f9\u517b24\u5c0f\u65f6\u7684\u7ec6\u80de\u6bd2\u6027\u3002<\/p>\n

\uff08G\uff09CLSM\u68c0\u6d4b30 \u03bcg\/mL\u7684CA\u6d53\u5ea6\u4e0bCT26\u7ec6\u80de\u4e0e\u6e38\u79bbCA\u3001P-CA\u548cTSEOP\u5b75\u80b224\u5c0f\u65f6\u540eHMGB1\u7684\u91ca\u653e\u3002<\/p>\n

\uff08H\uff0930 \u03bcg\/mL\u7684CA\u6d53\u5ea6\u4e0bCT26\u7ec6\u80de\u4e0e\u6e38\u79bbCA\u3001P-CA\u548cTSEOP\u5b75\u80b224\u5c0f\u65f6\u540eATP\u7684\u91ca\u653e\u3002<\/p>\n

\uff08I\uff09\u6d41\u5f0f\u7ec6\u80de\u672f\u68c0\u6d4bCT26\u7ec6\u80de\u4e0e\u6e38\u79bbCA\u3001P-CA\u548cTSEOP\u5728100 \u03bcg\/mL\u6d53\u5ea6\u4e0b\u5b75\u80b24h\u540e\u7684CRT\u9633\u6027\u7387\u3002<\/p>\n

\uff08J\uff09\u4f53\u5916DC\u7ec6\u80de\u6d3b\u5316\u5b9e\u9a8c\u793a\u610f\u56fe\u53ca\u6d41\u5f0f\u7ec6\u80de\u672f\u7ed3\u679c\u3002<\/p>\n

\u56fe\u56db\u3001\u4f53\u5185\u6297\u80bf\u7624\u4f5c\u7528<\/strong><\/p>\n

\"\"<\/p>\n

\uff08A\uff09\u4e0d\u540c\u6cbb\u7597\u540eCT26\u80bf\u7624\u8377\u7624\u5c0f\u9f20\u7684\u5e73\u5747\u80bf\u7624\u4f53\u79ef\u66f2\u7ebf\u3002<\/p>\n

\uff08B\uff09\u4e0d\u540c\u6cbb\u7597\u540eCT26\u80bf\u7624\u8377\u7624\u5c0f\u9f20\u7684\u80bf\u7624\u751f\u957f\u66f2\u7ebf\u3002<\/p>\n

\uff08C\uff09\u4e0d\u540c\u6cbb\u7597\u7ed3\u675f\u540eCT26\u80bf\u7624\u7684\u6d41\u5f0f\u7ec6\u80de\u672f\u7ed3\u679c\u3002<\/p>\n

\uff08D\uff09\u4e0d\u540c\u6cbb\u7597\u540e4T1\u80bf\u7624\u8377\u7624\u5c0f\u9f20\u7684\u5e73\u5747\u80bf\u7624\u4f53\u79ef\u66f2\u7ebf\u3002<\/p>\n

\uff08E\uff09\u4e0d\u540c\u6cbb\u7597\u540e\u76844T1\u80bf\u7624\u8377\u7624\u5c0f\u9f20\u7684\u80bf\u7624\u751f\u957f\u66f2\u7ebf\u3002<\/p>\n

\u56fe\u4e94\u3001\u514d\u75ab\u63a5\u79cd\u548c\u518d\u6311\u6218\u5b9e\u9a8c\u8bc4\u4f30<\/strong>TSEOP<\/strong>\u8bf1\u5bfc\u7684\u4f53\u5185\u80bf\u7624\u7279\u5f02\u6027\u514d\u75ab\u6548\u5e94<\/strong><\/p>\n

\"\"<\/p>\n

\uff08A\uff09\u75ab\u82d7\u63a5\u79cd\u548c\u518d\u6311\u6218\u5b9e\u9a8c\u8bbe\u8ba1\u793a\u610f\u56fe\u3002<\/p>\n

\uff08B\uff09\u63a5\u53d7\u5404\u79cd\u75ab\u82d7\u63a5\u79cd\u7684\u5c0f\u9f20\uff1aPBS\uff0cCT26\u7ec6\u80de\uff0cTSEOP-CT26\u7ec6\u80de\u540e\uff0c\u518d\u6311\u6218\u80bf\u7624\u7684\u80bf\u7624\u5e73\u5747\u4f53\u79ef\u66f2\u7ebf\u3002<\/p>\n

\uff08C\uff09\u5728\u63a5\u53d7\u4e0d\u540c\u7684\u514d\u75ab\u63a5\u79cd\u540e\uff0c\u518d\u6311\u6218\u7684\u80bf\u7624\u751f\u957f\u66f2\u7ebf\u3002<\/p>\n

\u3010\u7ed3\u8bba\u5c55\u671b\u3011<\/strong><\/p>\n

\u7efc\u4e0a\u6240\u8ff0\uff0c\u4f5c\u8005\u63d0\u51fa\u4e86\u4e00\u79cd\u5b89\u5168\u6709\u6548\u7684\u5229\u7528\u805a\u5408\u7269\u57fa\u7597\u6cd5\u6765\u6291\u5236\u80bf\u7624\u751f\u957f\u548c\u589e\u5f3a\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u3002\u901a\u8fc7\u5408\u7406\u8bbe\u8ba1\u7684\u7ed3\u6784\uff0cTSEOP\u53ef\u4ee5\u7279\u5f02\u6027\u5730\u534f\u540c\u589e\u52a0\u80bf\u7624\u7ec6\u80de\u7684\u6c27\u5316\u5e94\u6fc0\uff0c\u4ece\u800c\u5728\u4e0d\u6740\u6b7b\u6b63\u5e38\u7ec6\u80de\u7684\u60c5\u51b5\u4e0b\uff0c\u5bf9\u80bf\u7624\u7ec6\u80de\u4ea7\u751f\u6709\u6548\u7684ICD\u3002\u4f53\u5185\u5b9e\u9a8c\u7ed3\u679c\u8868\u660e\uff0c\u5355\u72ec\u4f7f\u7528TSEOP\u6cbb\u7597\u5373\u53ef\u540c\u65f6\u6839\u9664CT26\u7ed3\u80a0\u764c\u548c4T1\u4e09\u9634\u6027\u4e73\u817a\u764c\u3002\u8fdb\u4e00\u6b65\u7814\u7a76\u8868\u660e\uff0cTSEOP\u80fd\u6709\u6548\u6fc0\u6d3b\u4f53\u5185\u514d\u75ab\u7cfb\u7edf\uff0c\u4f7fCD3+<\/sup>CD8+<\/sup>T\u7ec6\u80de\u589e\u591a\uff0c\u5e76\u6fc0\u6d3b\u4e86DC\u7ec6\u80de\u548cM1\u578b\u5de8\u566c\u7ec6\u80de\u7684\u6d78\u6da6\u3002\u75ab\u82d7\u63a5\u79cd\u548c\u518d\u6311\u6218\u5b9e\u9a8c\u8bc1\u5b9eTSEOP\u53ef\u8bf1\u5bfc\u4f53\u5185\u80bf\u7624\u7279\u5f02\u6027\u6297\u80bf\u7624\u514d\u75ab\u3002TSEOP\u5177\u6709\u826f\u597d\u7684\u80bf\u7624\u9009\u62e9\u6027\u548c\u6297\u80bf\u7624\u6548\u679c\uff0c\u4e3a\u8bbe\u8ba1\u57fa\u4e8e\u805a\u5408\u7269\u7684\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u63d0\u4f9b\u4e86\u4e00\u79cd\u65b0\u7684\u9014\u5f84\uff0c\u4e5f\u53ef\u80fd\u6210\u4e3a\u4e00\u79cd\u5b89\u5168\u3001\u7ecf\u6d4e\u7684\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u65b9\u6cd5\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aRationally Designed Polymer Conjugate for Tumor-Specific Amplification of Oxidative Stress and Boosting Antitumor Immunity <\/a>(Nano Letters<\/em>, 2020<\/strong>, DOI: 10.1021\/acs.nanolett.9b05265)<\/p>\n

\u8bfe\u9898\u7ec4\u7b80\u4ecb\uff1a<\/strong><\/p>\n

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\u8bfe\u9898\u7ec4\u4e3b\u9875\uff1ahttp:\/\/www.biopolymer.cn<\/a><\/p>\n

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