{"id":202329,"date":"2020-05-28T17:30:30","date_gmt":"2020-05-28T09:30:30","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=202329"},"modified":"2020-05-28T17:29:37","modified_gmt":"2020-05-28T09:29:37","slug":"%e6%ad%a6%e6%b1%89%e5%a4%a7%e5%ad%a6%e5%bc%a0%e5%85%88%e6%ad%a3nat-commun-%ef%bc%9a%e5%9f%ba%e4%ba%8e%e7%96%ab%e8%8b%97%e7%9a%84%e7%ba%b3%e7%b1%b3%e7%b3%bb%e7%bb%9f%e7%94%a8%e4%ba%8e%e5%90%af","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=202329","title":{"rendered":"\u6b66\u6c49\u5927\u5b66\u5f20\u5148\u6b63Nat. Commun.\uff1a\u57fa\u4e8e\u75ab\u82d7\u7684\u7eb3\u7c73\u7cfb\u7edf\u7528\u4e8e\u542f\u52a8\u5929\u7136\u514d\u75ab\u548c\u589e\u5f3a\u80bf\u7624\u514d\u75ab\u6cbb\u7597"},"content":{"rendered":"

\u3010\u7814\u7a76\u80cc\u666f\u3011<\/strong><\/p>\n

\u514d\u75ab\u6cbb\u7597\u91ca\u653e\u60a3\u8005\u81ea\u8eab\u514d\u75ab\u7cfb\u7edf\u5728\u5404\u79cd\u4e0d\u53ef\u6cbb\u6108\u80bf\u7624\u4e2d\u53d6\u5f97\u4e86\u8f83\u597d\u7684\u4e34\u5e8a\u6548\u679c\u3002\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\uff08ICB\uff09\uff0c\u7279\u522b\u662f\u4ee5\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1\u86cb\u767d1\u6216\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1\u86cb\u767d1\uff08PD1\/PDL1\uff09\u4e3a\u9776\u70b9\u7684\u836f\u7269\u6cbb\u7597\u5728\u9ed1\u8272\u7d20\u7624\u3001\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u548c\u4e09\u9634\u6027\u4e73\u817a\u764c\uff08TNBC\uff09\u7684\u6cbb\u7597\u4e2d\u53d6\u5f97\u4e86\u6ee1\u610f\u7684\u7597\u6548\u3002\u5c3d\u7ba1\u5982\u6b64\uff0c\u4f46ICB\u6cbb\u7597\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u9762\u4e34\u7684\u4e00\u4e2a\u4e3b\u8981\u95ee\u9898\u662f\u53cd\u5e94\u7387\u6781\u4f4e\u3002\u5373\u4f7f\u662f\u9ed1\u8272\u7d20\u7624\uff0c\u4e00\u79cd\u6700\u5177\u514d\u75ab\u539f\u6027\u7684\u80bf\u7624\uff0c\u53ea\u670920-50%\u7684\u60a3\u8005\u53d7\u76ca\u4e8eICB\u6cbb\u7597\u3002\u636e\u62a5\u9053\uff0c\u7531\u4e8e\u5fae\u751f\u7269\u80fd\u591f\u5f15\u8d77\u5f3a\u5927\u548c\u6301\u4e45\u7684\u514d\u75ab\u5e94\u7b54\uff0c\u56e0\u6b64\u88ab\u7528\u4e8e\u63d0\u9ad8\u764c\u75c7\u6cbb\u7597\u7684\u6cbb\u7597\u53cd\u5e94\u7387\u3002\u7136\u800c\uff0c\u5b89\u5168\u6027\u95ee\u9898\u662f\u76ee\u524d\u57fa\u4e8e\u5fae\u751f\u7269\u6cbb\u7597\u7684\u6700\u5927\u96be\u9898\u3002\u4f8b\u5982\uff0c\u7531\u7ec6\u83cc\uff08\u5982\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\u548c\u611f\u67d3\uff09\u6216\u75c5\u6bd2\uff08\u4e3b\u8981\u662f\u75b2\u52b3\u3001\u53d1\u70e7\u548c\u5bd2\u6218\uff09\u5f15\u8d77\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u5f88\u5927\u7a0b\u5ea6\u4e0a\u9650\u5236\u4e86\u5b83\u4eec\u7684\u4e34\u5e8a\u8f6c\u5316\u80fd\u529b\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u5728\u5fae\u751f\u7269\u7279\u6027\u548c\u9002\u5f53\u7684\u751f\u7269\u5b89\u5168\u6027\u7684\u542f\u53d1\u4e0b\uff0c\u6b66\u6c49\u5927\u5b66\u5f20\u5148\u6b63\u6559\u6388\u56e2\u961f<\/strong>\u901a\u8fc7\u5c06Cd274\u7684siRNA\u6574\u5408\u5230\u5546\u4e1a\u5316\u7684\u4eba\u4e73\u5934\u7624\u75c5\u6bd2\uff08HPV\uff09L1\uff08HPV16 L1\uff09\u86cb\u767d\u4e2d\uff0c\u5236\u5907\u4e86\u4e00\u79cd\u57fa\u4e8e\u75ab\u82d7\u7684\u7eb3\u7c73\u7cfb\u7edf\uff0c\u7528\u4e8e\u7279\u5f02\u6027\u6291\u5236\u80bf\u7624PDL1\u8868\u8fbe\u3002\u53d7\u76ca\u4e8eHPV\u75ab\u82d7\u7684\u4f18\u70b9\uff0c\u8fd9\u79cdsiRNA\u8d1f\u8f7d\u7684\u7eb3\u7c73\u7cfb\u7edf\uff08siRNA@HPVP\uff09\u5177\u6709\u826f\u597d\u7684\u751f\u7269\u5b89\u5168\u6027\uff0c\u63d0\u9ad8\u4e86\u6297\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7684\u7597\u6548\u3002HPV16-L1\u86cb\u767d\u901a\u8fc7I\u578b\u5e72\u6270\u7d20\u9014\u5f84\u6fc0\u6d3b\u5148\u5929\u514d\u75ab\uff0c\u4e0eICB\u8054\u5408\u6cbb\u7597\u5177\u6709\u6709\u6548\u7684\u6297\u764c\u4f5c\u7528\u3002\u5bf9\u4e8e\u53ef\u5207\u9664\u548c\u4e0d\u53ef\u5207\u9664\u7684\u4e73\u817a\u80bf\u7624\uff0c\u7eb3\u7c73\u7cfb\u7edf\u53ef\u51cf\u5c1171%\u7684\u80bf\u7624\u590d\u53d1\uff0c\u5ef6\u957f67%\u7684\u5c0f\u9f20\u5b58\u6d3b\u671f\u3002\u6700\u91cd\u8981\u7684\u662f\uff0c\u8be5\u7eb3\u7c73\u7cfb\u7edf\u5728\u4e0d\u540c\u7a81\u53d8\u7684\u80bf\u7624\u8377\u7624\u5c0f\u9f20\u4e2d\uff0c\u6cbb\u7597\u54cd\u5e94\u7387\u4e5f\u975e\u5e38\u9ad8\u3002\u8fd9\u79cd\u57fa\u4e8e\u75ab\u82d7\u7684\u7eb3\u7c73\u7cfb\u7edf\u5f15\u53d1\u7684\u5f3a\u70c8\u514d\u75ab\u523a\u6fc0\u53ef\u80fd\u662f\u4e00\u79cd\u663e\u8457\u6539\u5584\u5f53\u524dICB\u514d\u75ab\u6cbb\u7597\u7684\u65b9\u6cd5\u3002\u8be5\u6587\u7ae0\u8fd1\u65e5\u4ee5\u9898\u4e3a\u201cA vaccine-based nanosystem for initiating innate immunity and improving tumor immunotherapy<\/strong>\u201d\u53d1\u8868\u5728\u77e5\u540d\u671f\u520aNature Communications<\/strong>\u4e0a\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe\u4e00\u3001<\/strong>siRNA@HPVP<\/strong>\u7684\u4f5c\u7528\u539f\u7406\u548c\u8868\u5f81<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff091097\u4eba\u7c7b\u4e73\u817a\u80bf\u7624\u548c114\u4e2a\u6765\u81eaUALCAN\u7684\u51c6\u764c\u7ec4\u7ec7\u80bf\u7624\u514d\u75ab\u8c03\u8282\u76f8\u5173\u57fa\u56e0\u7684\u8868\u8fbe\u3002<\/p>\n

\uff08b\uff09CD3E\/IRF7\u8868\u8fbe\u4e0eTCGA\u4e73\u817a\u80bf\u7624\u60a3\u8005\u751f\u5b58\u4e4b\u95f4\u7684\u76f8\u5173\u6027\u3002<\/p>\n

\uff08c\uff09siRNA@HPVP\u7cfb\u7edf\u8bbe\u8ba1\u548c\u529f\u80fd\u8fc7\u7a0b\u7684\u793a\u610f\u56fe\u3002<\/p>\n

\uff08d\uff09\u4e09\u4e2asiRNA\u5e8f\u5217\uff08100 nmol mL-1<\/sup>\uff09\u6c89\u9ed84T1\u7ec6\u80de\u540eCd274\u8f6c\u5f55\u7684PCR\u5206\u6790\u3002<\/p>\n

\uff08e\uff09\u5728HPVP\u4e0esiRNA\u7684\u4e0d\u540c\u8d28\u91cf\u6bd4\u4e0b\uff0csiRNA@HPVP\u7684\u51dd\u80f6\u7535\u6cf3\u3002<\/p>\n

\uff08f\uff09siRNA@HPVP\u7684\u4f4e\u6e29\u900f\u5c04\u7535\u955c\u56fe\u50cf\u3002<\/p>\n

\uff08g\uff09\u6d41\u5f0f\u5206\u6790\u57284T1\u7ec6\u80de\u548c4T1Itga6-<\/sup>\u7ec6\u80de\u4e2dsiRNA@HPVP\u7684\u6444\u53d6\u3002<\/p>\n

\u56fe\u4e8c\u3001\u4f53\u5916\u6297\u539f\u5448\u9012\u7ec6\u80de\uff08<\/strong>APCs<\/strong>\uff09\u6fc0\u6d3b<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09\u813e\u7ec6\u80de\u5bf94T1\u7ec6\u80de\u7684\u4f53\u5916\u6740\u4f24\u4f5c\u7528\uff08\u6548\u5e94\u7269-\u9776\u6bd4\u503c10:1\uff09\u3002<\/p>\n

\uff08b\uff09\u7528\u4e0d\u540csiRNA@HPVP\u5f62\u5f0f\uff08siRNA1@HPVP\u3001siRNA2@HPVP\u6216siRNA3@HPVP\uff09\u3001HPVP\u6216\u65b0\u9c9c\u57f9\u517b\u57fa\u5171\u540c\u5b75\u80b224\u5c0f\u65f6\u540e\uff0c\u5728CD11c+<\/sup>\u7ec6\u80de\u5171\u5b75\u80b2\u6210\u719fDC\uff08CD80+<\/sup>CD86+<\/sup>\uff09\u7684FACS\u6570\u636e\u3002<\/p>\n

\uff08c\uff09\u4e0d\u540c\u5904\u7406\u540eDCs\u4e2dIFN-\u03b1\u548cIFN-\u03b3\u7684\u8f6c\u5f55\u4e30\u5ea6\u3002<\/p>\n

\uff08d-e\uff09FACS\u6570\u636e\u663e\u793a\u5de8\u566c\u7ec6\u80de\uff08CD11b+<\/sup>CD80–<\/sup>\uff09\u7ecf\u8fc7\u4e0d\u540c\u5904\u7406\u540e6\u5c0f\u65f6\u8868\u578b\u548c\u6d3b\u5316\u6bd4\u4f8b\u3002<\/p>\n

\uff08f\uff09\u4e0d\u540c\u5904\u7406\u540eRAW 264.7\u5de8\u566c\u7ec6\u80de\u57f9\u517b\u6db2\u4e2d\u7ec6\u80de\u56e0\u5b50\u6c34\u5e73\u7684\u53d8\u5316\u3002<\/p>\n

\u56fe\u4e09\u3001<\/strong>siRNA2@HPVP<\/strong>\u7684\u80bf\u7624\u805a\u96c6\u548c\u6297\u80bf\u7624\u80fd\u529b<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09\u6ce8\u5c04HPVP\u5bf94T1\u8377\u7624\u5c0f\u9f20\u4f53\u5185\u80bf\u7624\u9776\u5411\u80fd\u529b\u7684\u7814\u7a76\u3002<\/p>\n

\uff08b\uff09\u7528\u4e8e\u8bc4\u4f30PDL1\u6291\u5236siRNA1@HPVP\u3001siRNA2@HPVP\u548csiRNA3@HPVP\u6548\u679c\u7684\u79bb\u4f53\u514d\u75ab\u8367\u5149\u56fe\u50cf<\/p>\n

\uff08c\uff09\u751f\u7269\u53d1\u5149\u6cd5\u539f\u4f4d\u68c0\u6d4bsiRNA2@HPVP\u5bf94T1\u80bf\u7624\u6cbb\u7597\u540e\u7684\u5148\u5929\u514d\u75ab\u53cd\u5e94\u3002<\/p>\n

\uff08d\uff09\u5bf9\u4e0d\u540c\u6cbb\u7597\u7ec4\u5728\u5c0f\u9f20\u76ae\u4e0b\u4e73\u817a\u80bf\u7624\u6a21\u578b\u4e0a\u7684\u4f53\u5185\u6297\u764c\u6548\u679c\u8bc4\u4f30\u3002<\/p>\n

\uff08e\uff09FACS\u5206\u6790\u7528\u4e8e\u6d4b\u91cfPBS\u6216siRNA2@HPVP\u6cbb\u7597\u5c0f\u9f20\u80bf\u7624\u4e2dPDL1\u86cb\u767d\u7684\u8868\u8fbe\u3002<\/p>\n

\uff08f\uff09\u4e0d\u540c\u6cbb\u7597\u540eKi67\u80bf\u7624\u7ec6\u80de\u7684\u5b9a\u91cf\u5206\u6790\u3002<\/p>\n

\uff08g\uff09\u4e0d\u540c\u6cbb\u7597\u540e\u6dcb\u5df4\u7ed3\u5185\u6210\u719fDCs\uff08CD11c+<\/sup>CD80+<\/sup>CD86+<\/sup>\uff09\u548c\u80bf\u7624\u6d78\u6da6\u6027\u7ec6\u80de\u6bd2T\u7ec6\u80de\uff08CD3+<\/sup>CD8+<\/sup>T\u7ec6\u80de\uff09\u7684FACS\u6570\u636e\u3002<\/p>\n

\uff08h\uff09FACS\u5206\u6790\u6cd5\u6d4b\u5b9a\u4e0d\u540c\u6cbb\u7597\u540e\u80bf\u7624\u5185M1\/M2\u5de8\u566c\u7ec6\u80de\u6bd4\u503c\u3002<\/p>\n

\uff08i\uff09\u4e0d\u540c\u5904\u7406\u540e12\u5c0f\u65f6\u5c0f\u9f20\u8840\u6e05IFN\u6c34\u5e73\u7684\u53d8\u5316\u3002<\/p>\n

\u56fe\u56db\u3001<\/strong>\u5148\u5929\u514d\u75ab\u7684\u6fc0\u6d3b\u673a\u5236<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09\u5728\u80bf\u7624\u5185\u6ce8\u5c043\u5929\u540e\uff0c\u7528siRNA2@HPVP\u6216aPDL1\u57284T1\u80bf\u7624\u4e2d\u8bc6\u522b\u5dee\u5f02\u8868\u8fbe\u7684\u57fa\u56e0\u3002<\/p>\n

\uff08b\uff09GeneMANIA\u7528\u4e8e\u9884\u6d4b\u514d\u75ab\u8fc7\u7a0bGO\u672f\u8bed\u4e2d\u5dee\u5f02\u57fa\u56e0\u4e4b\u95f4\u7684\u57fa\u56e0\u76f8\u4e92\u4f5c\u7528\u3002<\/p>\n

\uff08c\uff09KEGG\u6d53\u7f29\u5206\u6790siRNA2@HPVP\u6cbb\u7597\u5f15\u8d77\u7684\u751f\u7269\u6548\u5e94\u6240\u6d89\u53ca\u7684\u9014\u5f84\u3002<\/p>\n

\uff08d\uff09\u4e0d\u540c\u6cbb\u7597\u65b9\u6cd5\u5bf94T1\u80bf\u7624Tlr7\u3001Cxcl9\u3001Infb1\u3001Ifngr1\u548cIfng\u57fa\u56e0\u8f6c\u5f55\u4e30\u5ea6\u7684PCR\u5206\u6790\u3002<\/p>\n

\uff08e\uff09siRNA2@HPVP\u6fc0\u6d3b\u5148\u5929\u514d\u75ab\u7684\u53ef\u80fd\u673a\u5236\u7684\u539f\u7406\u56fe\u3002<\/p>\n

\uff08f\uff09\u77ac\u65f6\u8868\u8fbeTLR\u540c\u578b\u4e8c\u805a\u4f53\u548cELAM-Luc\u62a5\u544a\u8d28\u7c92\u7684HEK-293\u7ec6\u80de\u8bc1\u660esiRNA2@HPVP\u4ecb\u5bfc\u7684\u514d\u75ab\u53cd\u5e94\u4e0eTLR7\u76f8\u5173\u3002<\/p>\n

\uff08g\uff09\u6297IFNAR1\u6297\u4f53\u963b\u65ad\u2160\u578bIFN\u9014\u5f84\u6291\u5236siRNA2@HPVP\u6cbb\u7597\u3002<\/p>\n

\uff08h\uff09\u7528\u514d\u75ab\u8367\u5149\u67d3\u8272\u6cd5\u5b9a\u91cf\u5206\u6790\u4e0d\u540c\u6cbb\u7597\u65b9\u6cd5\u5bf94T1\u80bf\u7624T-bet\uff08\u5de6\uff09\u548cCD4\uff08\u53f3\uff09\u8868\u8fbe\u7684\u5f71\u54cd\u3002<\/p>\n

\u56fe\u4e94\u3001\u53ef\u5207\u9664\u548c\u4e0d\u53ef\u5207\u9664\u80bf\u7624\u6a21\u578b\u7684\u6cbb\u7597\u6548\u679c<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09\u8bc4\u4f30siRNA2@HPVP\u6cbb\u7597\u7684\u6297\u764c\u6548\u679c\u7684\u4e0d\u540c\u80bf\u7624\u6a21\u578b\u3002<\/p>\n

\uff08b\uff09\u6d3b\u4f53\u751f\u7269\u53d1\u5149\u56fe\u50cf\u5bf9\u539f\u53d1\u6027\u80bf\u7624\u5207\u9664\u540e4T1\u80bf\u7624\u7684\u590d\u53d1\u548c\u8f6c\u79fb\u7684\u793a\u8e2a\u3002<\/p>\n

\uff08c\uff09\u539f\u53d1\u6027\u80bf\u7624\u5207\u9664\u540e\u53ef\u5207\u9664\u5c0f\u9f20\u4e73\u817a\u80bf\u7624\u6a21\u578b\u7684\u75c5\u53d8\u60c5\u51b5\u3002<\/p>\n

\uff08d\uff09\u4e0d\u540c\u5904\u740640\u5929\u540e\u813e\u810f\u7ec4\u7ec7\u4e2dTEM<\/sub>\u7ec6\u80de\uff08CD8+<\/sup>CD44+<\/sup>CD62L–<\/sup>\uff09\u7684\u6bd4\u4f8b\u3002<\/p>\n

\uff08e\uff09\u4f53\u5185\u751f\u7269\u53d1\u5149\u56fe\u50cf\u663e\u793a\u5404\u79cd\u6cbb\u7597\u65b9\u6cd5\u7684\u6297\u8f6c\u79fb\u4f5c\u7528\u3002<\/p>\n

\uff08f-g\uff09\u9759\u8109\u6ce8\u5c044T1\u7ec6\u80de\u540e21\u5929\u80ba\u7ec4\u7ec7\u8f6c\u79fb\u7076\u5b9a\u91cf\u8ba1\u6570\u53caH&E\u67d3\u8272\u5207\u7247\u3002<\/p>\n

\uff08h\uff09\u4e0d\u540c\u6cbb\u7597\u65b9\u6cd5\u5bf9\u539f\u4f4d\u4e73\u817a\u764c\u8377\u7624\u5c0f\u9f20\u4f53\u5185\u751f\u7269\u53d1\u5149\u7684\u5f71\u54cd\u3002<\/p>\n

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\u56fe\u516d\u3001<\/strong>siRNA2@HPVP<\/strong>\u7684\u6cbb\u7597\u54cd\u5e94\u7387<\/strong><\/p>\n

\"\"<\/p>\n

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\u3010\u7ed3\u8bba\u5c55\u671b\u3011<\/strong><\/p>\n

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\u6587\u732e\u94fe\u63a5\uff1aA vaccine-based nanosystem for initiating innate immunity and improving tumor immunotherapy<\/a> (Nat. Commun.<\/em>, 2020<\/strong>, DOI: 10.1038\/s41467-020-15927-0)<\/p>\n

\u8bfe\u9898\u7ec4\u7b80\u4ecb\uff1a<\/strong><\/p>\n

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\u8bfe\u9898\u7ec4\u7f51\u7ad9\uff1ahttp:\/\/xzzhang.whu.edu.cn\/index.html<\/a><\/p>\n

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