{"id":205372,"date":"2020-07-15T06:03:23","date_gmt":"2020-07-14T22:03:23","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=205372"},"modified":"2020-07-14T22:03:35","modified_gmt":"2020-07-14T14:03:35","slug":"acc-chem-res-%e7%bb%bc%e8%bf%b0%ef%bc%9a%e7%94%a8%e4%ba%8e%e6%97%b6%e9%97%b4%e5%88%86%e8%be%a8%e5%8f%91%e5%85%89%e7%94%9f%e7%89%a9%e4%bc%a0%e6%84%9f%e5%92%8c%e6%88%90%e5%83%8f%e7%9a%84%e5%93%8d","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=205372","title":{"rendered":"Acc. Chem. Res.\u7efc\u8ff0\uff1a\u7528\u4e8e\u65f6\u95f4\u5206\u8fa8\u53d1\u5149\u751f\u7269\u4f20\u611f\u548c\u6210\u50cf\u7684\u54cd\u5e94\u578b\u91d1\u5c5e\u914d\u5408\u7269\u63a2\u9488"},"content":{"rendered":"

\u3010\u80cc\u666f\u4ecb\u7ecd\u3011<\/strong><\/p>\n

\u751f\u7269\u533b\u5b66\u7814\u7a76\u7684\u8fdb\u5c55\u5f88\u5927\u7a0b\u5ea6\u4e0a\u4f9d\u8d56\u4e8e\u5404\u79cd\u751f\u7269\u5206\u6790\u65b9\u6cd5\u7684\u53d1\u5c55\uff0c\u901a\u8fc7\u7cbe\u786e\u5730\u68c0\u6d4b\u7279\u5b9a\u7684\u751f\u7269\u5206\u5b50\uff0c\u5e76\u5bf9\u8fd9\u4e9b\u7269\u79cd\u5728\u590d\u6742\u7684\u751f\u7269\u7cfb\u7edf\u4e2d\u8fdb\u884c\u76d1\u6d4b\u4ee5\u63a2\u7a76\u751f\u7269\u5206\u5b50\u5728\u751f\u547d\u4f53\u4e2d\u8fd0\u884c\u673a\u5236\u3002\u5728\u5404\u79cd\u65b9\u6cd5\u4e2d\uff0c\u4f7f\u7528\u54cd\u5e94\u63a2\u9488\u7684\u53d1\u5149\u751f\u7269\u6d4b\u5b9a\u6280\u672f\u4f7f\u751f\u7269\u5b66\u7814\u7a76\u8fdb\u5165\u4e86\u4e00\u4e2a\u65b0\u7684\u9886\u57df\uff0c\u8fd9\u79cd\u6280\u672f\u53ef\u4ee5\u5728\u4e9a\u7ec6\u80de\u548c\/\u6216\u5206\u5b50\u6c34\u5e73\u4e0a\u66f4\u597d\u5730\u4e86\u89e3\u6d3b\u751f\u7269\u4f53\u4e2d\u751f\u7269\u5206\u5b50\u7684\u52a8\u6001\u3002\u5728\u8fc7\u53bb\u7684\u51e0\u5341\u5e74\u91cc\uff0c\u5927\u91cf\u7684\u6709\u673a\u67d3\u6599\u8367\u5149\u63a2\u9488\u88ab\u6210\u529f\u5730\u53d1\u5c55\u6210\u4e3a\u7814\u7a76\u751f\u7269\u5206\u5b50\u5728\u81ea\u7136\u73af\u5883\u4e2d\u6d3b\u52a8\u7684\u5de5\u5177\u3002\u4f5c\u4e3a\u8367\u5149\u6709\u673a\u67d3\u6599\u7684\u4e00\u79cd\u66ff\u4ee3\u6027\u53d1\u5149\u6750\u6599\uff0c\u4e00\u4e9b\u53d1\u5149\u91d1\u5c5e\u914d\u5408\u7269\u7279\u522b\u662f\u9567\u7cfb\u5143\u7d20\uff08\u5982Eu\uff08III\uff09\u548cTb\uff08III\uff09\uff09\u548c\u8fc7\u6e21\u91d1\u5c5e\uff08\u5982Ru\uff08II\uff09\u548cIr\uff08III\uff09\uff09\u914d\u5408\u7269\uff0c\u7531\u4e8e\u5176\u72ec\u7279\u7684\u5149\u7269\u7406\/\u5316\u5b66\u6027\u8d28\uff0c\u6b63\u88ab\u5e7f\u6cdb\u5c1d\u8bd5\u5e94\u7528\u4e8e\u751f\u7269\u4f20\u611f\u548c\u6210\u50cf\u9886\u57df\u4e2d\u3002\u8fd9\u4e9b\u62a5\u9053\u7684\u54cd\u5e94\u578b\u91d1\u5c5e\u914d\u5408\u7269\u63a2\u9488\u53ef\u4ee5\u901a\u8fc7\u7279\u5b9a\u7684\u8bc6\u522b\u53cd\u5e94\u5bf9\u7279\u5b9a\u7684\u5206\u6790\u7269\u505a\u51fa\u54cd\u5e94\uff0c\u4ece\u800c\u4fdd\u8bc1\u4e86\u63a2\u9488\u5bf9\u8be5\u5206\u6790\u7269\u7684\u9ad8\u9009\u62e9\u6027\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0c\u91d1\u5c5e\u914d\u5408\u7269\u63a2\u9488\u7684\u957f\u5bff\u547d\u53d1\u5149\u53ef\u4ee5\u663e\u8457\u5730\u6d88\u9664\u80cc\u666f\u81ea\u8367\u5149\u548c\u5149\u6563\u5c04\u7684\u5e72\u6270\u3002<\/p>\n

\u5229\u7528\u957f\u5bff\u547d\u53d1\u5149\u63a2\u9488\u8fdb\u884c\u65f6\u95f4\u5206\u8fa8\uff08\u65f6\u95f4\u95e8\u63a7\uff09\u53d1\u5149\uff08TGL\uff09\u751f\u7269\u68c0\u6d4b\u5df2\u5e7f\u6cdb\u5e94\u7528\u4e8e\u4e34\u5e8a\u8bca\u65ad\u548c\u751f\u7269\u533b\u5b66\u7814\u7a76\u3002\u7531\u4e8e\u80fd\u6709\u6548\u5730\u6d88\u9664\u80cc\u666f\u4fe1\u53f7\uff0cTGL\u6280\u672f\u663e\u8457\u63d0\u9ad8\u4e86\u7075\u654f\u5ea6\u548c\u4fe1\u566a\u6bd4\uff0c\u4ece\u800c\u51cf\u5c11\u4e86\u751f\u7269\u68c0\u6d4b\u4e2d\u7684\u5047\u9633\u6027\/\u9634\u6027\u4fe1\u53f7\u3002\u6b64\u5916\uff0cTGL\u663e\u5fae\u955c\u7684\u5feb\u901f\u53d1\u5c55\u4e5f\u4fc3\u8fdb\u4e86\u54cd\u5e94\u578b\u91d1\u5c5e\u914d\u5408\u7269\u63a2\u9488\u5728\u7ec6\u80de\u3001\u4e9a\u7ec6\u80de\u548c\u5206\u5b50\u6c34\u5e73\u4e0a\u7684\u52a8\u6001\u5206\u6790\u5e94\u7528\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u6700\u8fd1\uff0c\u5927\u8fde\u7406\u5de5\u5927\u5b66\u8881\u666f\u5229\u6559\u6388\u548c\u6fb3\u5927\u5229\u4e9a\u6606\u58eb\u5170\u5927\u5b66<\/strong>Run Zhang<\/strong>\u535a\u58eb<\/strong>\u7efc\u8ff0\u4e86\u8fd1\u5e74\u6765\u5173\u4e8e\u65f6\u95f4\u5206\u8fa8\u53d1\u5149\u751f\u7269\u4f20\u611f\u548c\u6210\u50cf\u7684\u91d1\u5c5e\u914d\u5408\u7269\u63a2\u9488\u7684\u6700\u65b0\u7814\u7a76\u8fdb\u5c55\u3002\u4ee5\u201cResponsive Metal Complex Probes for Time-Gated Luminescence Biosensing and Imaging<\/strong>\u201d\u53d1\u8868\u4e8eAcc. Chem. Res<\/strong>\u671f\u520a\u4e0a\u3002\u5728\u672c\u6587\u4e2d\uff0c\u4f5c\u8005\u9996\u5148\u4ecb\u7ecd\u4e86\u5305\u62ec\u9567\u7cfb\uff08\u94d5\u548c\u94fd\uff09\u548c\u8fc7\u6e21\u91d1\u5c5e\uff08\u948c\u548c\u94f1\uff09\u914d\u5408\u7269\u7b49\u53d1\u5149\u91d1\u5c5e\u914d\u5408\u7269\u7684\u5149\u7269\u7406\/\u5316\u5b66\u6027\u8d28\u3002\u63a5\u7740\u4ecb\u7ecd\u4e86\u8fd9\u4e9b\u957f\u5bff\u547d\u53d1\u5149\u7684\u91d1\u5c5e\u914d\u5408\u7269\u80fd\u591f\u7528\u4e8e\u68c0\u6d4b\u67d0\u4e9b\u6d3b\u6027\u751f\u7269\u5206\u5b50\uff0c\u5982\u6d3b\u6027\u6c27\/\u6c2e\u7269\u79cd\uff08ROS\/RNS\uff09\u548c\u751f\u7269\u786b\u9187\u54cd\u5e94\u63a2\u9488\u65b9\u9762\u7684\u5e94\u7528\u3002\u6700\u540e\uff0c\u4f5c\u8005\u8fd8\u8fdb\u4e00\u6b65\u6982\u8ff0\u4e86\u5f00\u53d1\u65b0\u4e00\u4ee3\u54cd\u5e94\u578bTGL\u63a2\u9488\u4ee5\u4fc3\u8fdb\u5176\u5b9e\u9645\u5e94\u7528\u7684\u672a\u6765\u65b9\u5411\u3002\u6700\u540e\u4f5c\u8005\u8fd8\u5c55\u671b\u4e86\u54cd\u5e94\u578bTGL\u63a2\u9488\u7684\u8fdb\u4e00\u6b65\u5f00\u53d1\uff0c\u8fd9\u5c06\u6709\u52a9\u4e8e\u66f4\u5177\u6311\u6218\u6027\u7684\u751f\u7269\u7cfb\u7edf\u7684\u751f\u7269\u68c0\u6d4b\u3002<\/p>\n

\u3010\u56fe\u6587\u89e3\u8bfb\u3011<\/strong><\/p>\n

1<\/strong>\u3001\u5f15\u8a00<\/strong><\/p>\n

2<\/strong>\u3001\u957f\u5bff\u547d\u53d1\u5149\u91d1\u5c5e<\/strong>\u914d<\/strong>\u5408\u7269\u63a2\u9488<\/strong><\/p>\n

\u56fe\u4e00\u3001<\/strong>BHHCT-Eu<\/strong>\u3001<\/strong>BHHBCB-Eu<\/strong>\u3001<\/strong>BPTA-Eu\/Tb<\/strong>\u3001<\/strong>PTTA-Eu\/Tb<\/strong>\u3001<\/strong>Ru(bpy)3<\/sub>2+<\/sup><\/strong>\u3001<\/strong>Ru(phen)3<\/sub>2+<\/sup><\/strong>\u548c<\/strong>Ir(ppy)2<\/sub>(bpy)+<\/sup><\/strong>\u7684\u7ed3\u6784\u793a\u610f\u56fe<\/strong><\/p>\n

\"\"3<\/strong>\u3001\u7528\u4e8e<\/strong>TGL<\/strong>\u751f\u7269\u4f20\u611f\u548c\u6210\u50cf\u7684\u7a00\u571f\u914d\u5408\u7269\u63a2\u9488<\/strong><\/p>\n

3.1<\/strong>\u3001\u201c\u5173<\/strong>–<\/strong>\u5f00\u201d\u578b<\/strong>Eu(III)\/Tb(III)<\/strong>\u914d<\/strong>\u5408\u7269\u8367\u5149\u63a2\u9488<\/strong><\/p>\n

\u56fe\u4e8c\u3001\u54cd\u5e94\u578b<\/strong>Eu(III)\/Tb(III)<\/strong>\u914d\u5408\u7269<\/strong>\u63a2\u9488\u7528\u4e8e<\/strong>1<\/sup><\/strong>O2<\/sub><\/strong>\u7684<\/strong>TGL<\/strong>\u68c0\u6d4b<\/strong><\/p>\n

\"\"\uff08A\uff09ATTA-Eu\uff0cPATA-Tb\uff0cMTTA-Eu\u7684\u7ed3\u6784\u53ca\u5176\u4e0e1<\/sup>O2<\/sub>\u7684\u53cd\u5e94\uff1b<\/p>\n

\uff08B\uff09MTTA-Eu\u4e0e\u4e0d\u540c\u6d53\u5ea61<\/sup>O2<\/sub>\u53cd\u5e94\u7684\u65f6\u95f4\u5206\u8fa8\u6fc0\u53d1\u548c\u53d1\u5c04\u5149\u8c31\uff1b<\/p>\n

\uff08C\uff09\u4e0d\u540c\u7167\u5c04\u65f6\u95f4\u4e0b\u542b\u6709TMPyP-MTTA-Eu\u7684HeLa\u7ec6\u80de\u7684\u660e\u573a\u56fe\u548cTGL\u56fe\u50cf<\/p>\n

\u56fe\u4e09\u3001\u63a2\u9488<\/strong>BMTA-Tb<\/strong>\u7528\u4e8e\u8fc7\u6c27\u5316\u6c22\u7684<\/strong>TGL<\/strong>\u68c0\u6d4b\u548c\u6210\u50cf<\/strong><\/p>\n

\"\"\uff08A\uff09BMTA-Tb\u7684\u7ed3\u6784\u53ca\u5176\u4e0eH2<\/sub>O2<\/sub>\u7684\u53cd\u5e94\uff1b<\/p>\n

\uff08B\uff09\u4f4e\u805a\u7cd6\uff080.2g\/L\uff09\u5904\u74065h\u524d\u540eBMTA-Tb\u67d3\u8272\u70df\u8349\u53f6\u7247\u7ec4\u7ec7\u7684TGL\u548c\u7a33\u6001\u53d1\u5149\u56fe\u50cf\u3002<\/p>\n

\u56fe\u56db\u3001<\/strong>\u54cd\u5e94\u578b<\/strong>Eu(III)\/Tb(III)<\/strong>\u914d\u5408\u7269<\/strong>\u63a2\u9488\u7528\u4e8e<\/strong>HOCl<\/strong>\u7684<\/strong>TGL<\/strong>\u68c0\u6d4b<\/strong><\/p>\n

\"\"\uff08A\uff09AMTTA-Eu\/AMTTA-Tb\u63a2\u9488\u7684\u7ed3\u6784\u53ca\u5176\u4e0eHOCl\u7684\u53cd\u5e94\uff1b<\/p>\n

\uff08B\uff0cC\uff09AMTTA Eu\/AMTTA-Tb\u63a2\u9488\u4e0e\u4e0d\u540c\u6d53\u5ea6HOCl\u53cd\u5e94\u7684TGL\u5149\u8c31\uff08\u63d2\u56fe\uff1aHOCl\u7684TGL\u68c0\u6d4b\u6807\u51c6\u66f2\u7ebf\uff09\uff1b<\/p>\n

\uff08D\uff09HeLa\u7ec6\u80de\u4e2d\u5916\u6e90\u6027HOCl\u7684TGL\u6210\u50cf\u3002<\/p>\n

3.2<\/strong>\u3001\u6bd4\u7387\u578b<\/strong>Eu(III)\/Tb(III)<\/strong>\u914d<\/strong>\u5408\u7269\u8367\u5149\u63a2\u9488<\/strong><\/p>\n

\u56fe\u4e94\u3001<\/strong>\u53bb\u6838\u94c1<\/strong>\u86cb\u767d\u7ec4\u88c5<\/strong>PTTA-Tb-<\/strong>\u7f57\u4e39\u660e<\/strong>-FRET<\/strong>\u63a2\u9488\u6bd4\u7387<\/strong>\u68c0\u6d4b<\/strong>\u4e00\u6c27\u5316\u6c2e<\/strong><\/p>\n

\"\"\uff08A\uff09PTTATb@AFt-Rh-NO\u5bf9NO\u7684\u53d1\u5149\u54cd\u5e94\u793a\u610f\u56fe\u4ee5\u53caPTTA-Tb\u548cRh-NO\u7684\u7ed3\u6784\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08B\uff09PTTATb@AFt-Rh-NO\u4e0e\u4e0d\u540c\u6d53\u5ea6\u7684NO\u53cd\u5e94\u7684TGL\u5149\u8c31\uff0c\u5f97\u5230\u6bd4\u7387\u578bTGL\u5206\u6790\u7684\u6807\u51c6\u66f2\u7ebf\uff1b<\/p>\n

\uff08C\uff09HepG2\u7ec6\u80de\u548cD. magna<\/em>\u4e2dNO\u7684\u7a33\u6001\u8367\u5149\u548c\u6bd4\u7387TGL\u6210\u50cf\u3002<\/p>\n

\u56fe\u516d\u3001\u57fa\u4e8e<\/strong>Eu(III)\/Tb(III)<\/strong>\u53cc\u9567\u7cfb<\/strong>\u6df7\u5408<\/strong>\u7b56\u7565\u7684\u6bd4\u7387\u578b<\/strong>TGL<\/strong>\u63a2\u9488<\/strong><\/p>\n

\"\"\uff08A\uff0cB\uff09HTTA-Eu\/Tb\u7684\u7ed3\u6784\uff08A\uff09\u53ca\u5176\u5728\u4e0d\u540cpH\uff08B\uff09\u4e0b\u7684TGL\u8c31\uff1b<\/p>\n

\uff08C\uff09NSTTA-Eu\/Tb\u548cNPTTA-Eu\/Tb\u7684\u7ed3\u6784\u53ca\u5176\u4e0e\u751f\u7269\u786b\u9187\u548cH2<\/sub>S\u7684\u53cd\u5e94\u3002<\/p>\n

\u56fe\u4e03\u3001\u6bd4\u7387\u578b<\/strong>TGL<\/strong>\u7eb3\u7c73\u63a2\u9488\u7528\u4e8e<\/strong>HOCl<\/strong>\u7684\u68c0\u6d4b\u548c\u6210\u50cf<\/strong><\/p>\n

\"\"\uff08A\uff09\u57fa\u4e8e\u914d\u5408\u7269PTTA-Tb\u5305\u57cb\uff08\u6838\uff09\u53caBHHBB-Eu\u4fee\u9970\uff08\u58f3\uff09\u7845\u80f6\u7eb3\u7c73\u9897\u7c92\u7684HOCl\u6bd4\u7387\u578bTGL\u7eb3\u7c73\u63a2\u9488\uff08RTLNP\uff09\u7684\u8bbe\u8ba1\uff1b<\/p>\n

\uff08B\uff09\u7528\u4e8eHOCl\u68c0\u6d4b\u7684RTLNP\u7684TGL\u5149\u8c31\uff1b<\/p>\n

\uff08C\uff09RAW 264.7\u7ec6\u80de\uff08\u7ec6\u80de\u7ecfLPS\/INF-\u03b3\/PMA\u548c\u5927\u80a0\u6746\u83cc\uff0c\u6291\u5236\u5242\uff1a4-\u6c28\u57fa\u82ef\u7532\u9178\u9170\u80bc\uff09\u4e2dHOCl\u751f\u6210\u7684\u6bd4\u7387TGL\u6210\u50cf\u3002<\/p>\n

3.3<\/strong>\u3001<\/strong>\u7ec6\u80de\u5668\u7279\u5f02\u6027<\/strong>\u6bd4\u7387\u578b<\/strong>Eu(III)\/Tb(III)<\/strong>\u914d\u5408\u7269\u8367\u5149\u63a2\u9488<\/strong><\/p>\n

\u56fe\u516b\u3001\u6bd4\u7387\u578b<\/strong>TGL<\/strong>\u63a2\u9488<\/strong>TRP-NO<\/strong>\u7528\u4e8e\u6eb6\u9176\u4f53<\/strong>NO<\/strong>\u7684\u68c0\u6d4b\u548c\u6210\u50cf<\/strong><\/p>\n

\"\"\uff08A\uff09TRP-NO\u7684\u7ed3\u6784\u53ca\u5176\u54cd\u5e94NO\u7684\u53cd\u5e94\uff1b<\/p>\n

\uff08B\uff09\u4e0d\u540c\u6d53\u5ea6NO\u5b58\u5728\u4e0bTRP-NO\u7684TGL\u5149\u8c31\u548cNO\u68c0\u6d4b\u7684\u6807\u51c6\u66f2\u7ebf\uff1b<\/p>\n

\uff08C\uff09HepG2\u7ec6\u80de\u5185TRP-NO\u548c\u6eb6\u9176\u4f53\u7eff\u7684\u5171\u5b9a\u4f4d\u5206\u6790\uff1b<\/p>\n

\uff08D\uff09HepG2\u7ec6\u80deNO\u7684\u7a33\u6001\u8367\u5149\u548cTGL\u6210\u50cf\u3002<\/p>\n

\u56fe\u4e5d\u3001\u57fa\u4e8e<\/strong>Eu(III)\/Tb(III)<\/strong>\u53cc\u9567\u7cfb<\/strong>\u6df7\u5408<\/strong>\u6cd5<\/strong>\u7684\u6bd4\u7387\u578b\u63a2\u9488<\/strong>ER-NFTTA-Eu\/Tb<\/strong>\u7528\u4e8e<\/strong>\u5185\u8d28\u7f51<\/strong>\u4e2d<\/strong>O2<\/sub>\u2022\u2212<\/sup><\/strong>\u7684<\/strong>T<\/strong>GL<\/strong>\u68c0\u6d4b\u4e0e\u6210\u50cf<\/strong><\/p>\n

\"\"\uff08A\uff09ER-NFTTA-Eu\/Tb\u7684\u7ed3\u6784\u53ca\u5176\u4e0eO2<\/sub>\u2022\u2212<\/sup>\u7684\u53cd\u5e94\uff1b<\/p>\n

\uff08B\uff09ER-NFTTA-Eu\/Tb\u4e0eO2\u2022\u2212\u53cd\u5e94\u7684TGL\u5149\u8c31\uff1b<\/p>\n

\uff08C\uff09\u5206\u522b\u5728LPS\uff0810\u03bcg\/mL\uff09\u548c\u987a\u94c2\uff08300\u03bcM\uff09\u523a\u6fc0\u4e0bHepG2\u548cHK-2\u7ec6\u80deO2<\/sub>\u2022\u2212<\/sup>\u4ea7\u751f\u7684\u6bd4\u7387TGL\uff08\u5ef6\u8fdf33\u03bcs\uff09\u6210\u50cf\u3002<\/p>\n

\u56fe\u5341\u3001\u57fa\u4e8e<\/strong>Eu(III)\/Tb(III)<\/strong>\u53cc\u9567\u7cfb<\/strong>\u6df7\u5408<\/strong>\u6cd5\u7684<\/strong>\u7684\u6bd4\u7387\u578b\u63a2\u9488<\/strong>Mito-NBTTA-Eu\/Tb<\/strong>\u7528\u4e8e\u7ebf\u7c92\u4f53\u4e2d<\/strong>CO<\/strong>\u7684<\/strong>TGL<\/strong>\u68c0\u6d4b\u4e0e\u6210\u50cf<\/strong><\/p>\n

\"\"<\/strong>\uff08A\uff09Mito-NBTTA-Eu\/Tb\u7684\u7ed3\u6784\u53ca\u5176\u4e0eCO\u7684\u53cd\u5e94\uff1b<\/p>\n

\uff08B\uff09Mito-NBTTA-Eu\/Tb\u4e0eCO\u53cd\u5e94\u7684TGL\u5149\u8c31\uff1b<\/p>\n

\uff08C\uff09HeLa\u7ec6\u80de\u548c\u5c0f\u9f20\u809d\u7ec4\u7ec7\u4e2dCO\u7684\u6bd4\u7387TGL\u6210\u50cf\u3002<\/p>\n

4<\/strong>\u3001\u7528\u4e8e<\/strong>TGL<\/strong>\u751f\u7269\u4f20\u611f\u548c\u6210\u50cf\u7684\u8fc7\u6e21\u91d1\u5c5e<\/strong>\u914d<\/strong>\u5408\u7269\u63a2\u9488<\/strong><\/p>\n

4.1<\/strong>\u3001<\/strong>\u54cd\u5e94\u578b<\/strong>Ru(II)<\/strong>\u914d\u5408\u7269<\/strong>\u63a2\u9488<\/strong><\/p>\n

\u56fe\u5341\u4e00\u3001\u54cd\u5e94\u578b<\/strong>Ru(II<\/strong>)<\/strong>\u914d\u5408\u7269<\/strong>\u63a2\u9488<\/strong>Ru-2<\/strong>\u7528\u4e8e\u751f\u7269\u786b\u9187\u68c0\u6d4b<\/strong>
\n \"\"\uff08A\uff09Ru-2\u7684\u7ed3\u6784\u53ca\u5176\u4e0e\u751f\u7269\u786b\u9187\u7684\u53cd\u5e94\uff1b<\/p>\n

\uff08B\uff0cC\uff09\u63a2\u9488\u7528\u4e8e\u4eba\u8840\u6e05\u4e2d\u751f\u7269\u786b\u9187\u7684\u7a33\u6001\u53d1\u5149\uff08B\uff09\u548cTGL\uff08C\uff0c100ns\u5ef6\u8fdf\uff09\u5206\u6790\u3002<\/p>\n

\u56fe\u5341\u4e8c\u3001\u54cd\u5e94\u578b<\/strong>Ru(II)<\/strong>\u914d\u5408\u7269<\/strong>\u63a2\u9488<\/strong>Ru-MDB<\/strong>\u7528\u4e8e<\/strong>H2<\/sub>S<\/strong>\u68c0\u6d4b<\/strong><\/p>\n

\"\"\uff08A\uff09Ru-MDB\u7684\u7ed3\u6784\u53ca\u5176\u4e0eH2<\/sub>S\u7684\u53cd\u5e94\uff1b<\/p>\n

\uff08B~D\uff09\u63a2\u9488\u7528\u4e8e\u4eba\u8840\u6e05\u4e2dH2<\/sub>S\u68c0\u6d4b\u7684\u7a33\u6001\u53d1\u5149\uff08B\uff09\u548cTGL\uff08C\uff09\u5149\u8c31\u548c\u6807\u51c6\u66f2\u7ebf\uff08D\uff09\uff1b<\/p>\n

\uff08E\uff09\u7528TGL\u6cd5\u5206\u6790\u6210\u5e74\u6591\u9a6c\u9c7c\u5668\u5b98\u4e2dH2<\/sub>S\u542b\u91cf\u3002<\/p>\n

\u56fe\u5341\u4e09\u3001\u54cd\u5e94\u578b<\/strong>Ru(II)<\/strong>\u914d\u5408\u7269<\/strong>\u63a2\u9488<\/strong>Ru-FA<\/strong>\u7528\u4e8e\u7532\u919b\u68c0\u6d4b<\/strong><\/p>\n

\"\"\uff08A\uff09Ru-FA\u7684\u7ed3\u6784\u53ca\u5176\u4e0e\u7532\u919b\u7684\u53cd\u5e94\uff1b<\/p>\n

\uff08B~D\uff09\u63a2\u9488\u7528\u4e8e\u4eba\u8840\u6e05\u4e2d\u7532\u919b\u68c0\u6d4b\u7684\u7a33\u6001\u53d1\u5149\uff08B\uff09\u548cTGL\uff08C\uff09\u5149\u8c31\u548c\u6807\u51c6\u66f2\u7ebf\uff08D\uff09\uff1b<\/p>\n

\uff08E\uff09\u7528TGL\u6cd5\u5206\u6790\u5c0f\u9f20\u5668\u5b98\u4e2d\u7532\u919b\u542b\u91cf\u3002<\/p>\n

4.2<\/strong>\u3001\u54cd\u5e94\u578b<\/strong>Ir(III)<\/strong>\u914d\u5408\u7269<\/strong>\u63a2\u9488<\/strong><\/p>\n

\u56fe\u5341\u56db\u3001\u54cd\u5e94\u578b<\/strong>Ir(III)<\/strong>\u914d\u5408\u7269\u63a2\u9488<\/strong>[Ir(ppy)2<\/sub>(NTY-bpy)]+<\/sup><\/strong>\u7528\u4e8e<\/strong>Cys<\/strong>\u68c0\u6d4b<\/strong><\/p>\n

\"\"\uff08A\uff09[Ir(ppy)2<\/sub>(NTY-bpy)]+<\/sup>\u7684\u7ed3\u6784\u53ca\u5176\u4e0eCys\u7684\u53cd\u5e94\uff1b<\/p>\n

\uff08B~D\uff09\u63a2\u9488\u7528\u4e8e\u6d4b\u5b9aCys\u7684TGL\u8c31\uff08B\uff09\u548c\u6807\u51c6\u66f2\u7ebf\uff08C\uff09\u53ca\u4eba\u8840\u6e05\u4e2dCys\u7684\u6d4b\u5b9a\uff08D\uff09\uff1b<\/p>\n

\uff08E\uff09\u63a2\u9488\u548c\u6eb6\u9176\u4f53\u7eff\u5171\u67d3\u8272MCF-7\u7ec6\u80de\u7684\u7a33\u6001\u6210\u50cf\u4e0eTGL\u6210\u50cf\u3002<\/p>\n

5<\/strong>\u3001\u603b\u7ed3<\/strong><\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

\u7efc\u4e0a\u6240\u8ff0\uff0c\u4f5c\u8005\u603b\u7ed3\u4e86\u8fd1\u4e9b\u5e74\u7528\u4e8eTGL\u751f\u7269\u4f20\u611f\u548c\u6210\u50cf\u7684\u91d1\u5c5e\u914d\u5408\u7269\u63a2\u9488\u65b9\u9762\u7684\u5de5\u4f5c\u3002\u8fd9\u4e9b\u7814\u7a76\u4e3b\u8981\u96c6\u4e2d\u5728\u5229\u7528\u957f\u5bff\u547d\u53d1\u5149\u7684\u9567\u7cfb\u5143\u7d20\uff08Eu\uff08III\uff09\/Tb\uff08III\uff09\uff09\u548c\u8fc7\u6e21\u91d1\u5c5e\uff08Ru\uff08II\uff09\/Ir\uff08III\uff09\uff09\u914d\u5408\u7269\u6765\u5f00\u53d1\u4e3b\u8981\u7528\u4e8e\u68c0\u6d4bROS\/RNS\u548c\u6297\u6c27\u5316\u5242\uff08\u751f\u7269\u786b\u9187\uff09\u7684\u54cd\u5e94\u578bTGL\u63a2\u9488\u3002\u4f5c\u8005\u8ba4\u4e3a\uff0c\u5c3d\u7ba1\u76ee\u524d\u4eba\u4eec\u5728\u5f00\u53d1\u548c\u5e94\u7528TGL\u751f\u7269\u68c0\u6d4b\u54cd\u5e94\u578b\u63a2\u9488\u65b9\u9762\u53d6\u5f97\u4e86\u5f88\u597d\u7684\u8fdb\u5c55\uff0c\u4f46\u4ecd\u9700\u8fdb\u4e00\u6b65\u52aa\u529b\u4ee5\u63a8\u52a8\u8fd9\u9879\u6280\u672f\u5728\u672a\u6765\u7684\u751f\u7269\u533b\u5b66\u5e94\u7528\u4e2d\u7684\u53d1\u5c55\u3002\u800c\u5bf9\u4e8e\u4e0b\u4e00\u4ee3\u54cd\u5e94\u578bTGL\u63a2\u9488\u7684\u5f00\u53d1\uff0c\u4f5c\u8005\u8ba4\u4e3a\u9700\u8981\u8003\u8651\u7684\u5173\u952e\u6807\u51c6\u662f\u53ef\u9006\u6027\u3001\u8f83\u9ad8\u7684\u751f\u7269\u76f8\u5bb9\u6027\u4ee5\u53ca\u4f7f\u7528\u4f4e\u80fd\u91cf\u5149\u5b50\u6fc0\u53d1\u7684\u80fd\u529b\uff0c\u4f8b\u5982\u7528\u4e8e\u6df1\u5c42\u7ec4\u7ec7\u68c0\u6d4b\u6210\u50cf\u7684\u591a\u5149\u5b50\u6fc0\u53d1\uff08700\u22121000 nm\uff09\u4f53\u7cfb\u3002\u540c\u65f6\uff0c\u4f5c\u8005\u8ba4\u4e3a\u5bf9\u4e8e\u5df2\u5f00\u53d1\u63a2\u9488\u7684\u751f\u7269\u533b\u5b66\u5e94\u7528\u800c\u8a00\uff0c\u5c06\u8fd9\u4e9b\u63a2\u9488\u8f6c\u5316\u4e3a\u5b9e\u7528\u5de5\u5177\u662f\u53e6\u4e00\u4e2a\u9700\u8981\u901a\u8fc7\u4e0e\u751f\u7269\u5b66\u5bb6\u3001\u533b\u5b66\u4ece\u4e1a\u4eba\u5458\u3001\u4e34\u5e8a\u533b\u751f\u548c\u5de5\u4e1a\u754c\u7684\u5bc6\u5207\u5408\u4f5c\u6765\u5e94\u5bf9\u7684\u6311\u6218\u3002\u6b64\u5916\uff0c\u8003\u8651\u5230\u54cd\u5e94\u578bTGL\u63a2\u9488\u6280\u672f\u7684\u72ec\u7279\u4f18\u52bf\uff0c\u4f5c\u8005\u9884\u8ba1\u54cd\u5e94\u578bTGL\u63a2\u9488\u7684\u8fdb\u4e00\u6b65\u5f00\u53d1\u5c06\u6709\u52a9\u4e8e\u5728\u66f4\u5177\u6311\u6218\u6027\u7684\u751f\u7269\u7cfb\u7edf\uff08\u4f8b\u5982\u6bd4\u52a8\u7269\u5177\u6709\u66f4\u9ad8\u80cc\u666f\u81ea\u4f53\u8367\u5149\u7684\u690d\u7269\u4f53\uff09\u4e2d\u8fdb\u884c\u751f\u7269\u68c0\u6d4b\u3002<\/p>\n

\u00a0<\/h1>\n

 <\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aResponsive Metal Complex Probes for Time-Gated Luminescence Biosensing and Imaging<\/a>\uff08Acc. Chem. Res.<\/em> 2020<\/strong>, DOI:https:\/\/dx.doi.org\/10.1021\/acs.accounts.0c00172\uff09<\/p>\n

 <\/p>\n

\u672c\u6587\u7531\u6211\u4ea6\u662f\u884c\u4eba\u7f16\u8bd1\u3002<\/p>\n

\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1\uff1atougao@cailiaoren.com.<\/a><\/p>\n

\u6295\u7a3f\u4ee5\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1acailiaokefu.<\/p>\n","protected":false},"excerpt":{"rendered":"

\u3010\u80cc\u666f\u4ecb\u7ecd\u3011 \u751f\u7269\u533b\u5b66\u7814\u7a76\u7684\u8fdb\u5c55\u5f88\u5927\u7a0b\u5ea6\u4e0a\u4f9d\u8d56\u4e8e\u5404\u79cd\u751f\u7269\u5206\u6790\u65b9\u6cd5\u7684\u53d1\u5c55\uff0c\u901a\u8fc7\u7cbe\u786e\u5730\u68c0\u6d4b\u7279\u5b9a\u7684\u751f\u7269\u5206\u5b50\uff0c\u5e76\u5bf9\u8fd9\u4e9b\u7269\u79cd\u5728\u590d\u6742\u7684\u751f\u7269\u7cfb\u7edf\u4e2d\u8fdb\u884c\u76d1\u6d4b\u4ee5\u63a2\u7a76\u751f\u7269\u5206\u5b50\u5728\u751f\u547d…<\/p>\n","protected":false},"author":11455,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[533],"tags":[4411],"class_list":["post-205372","post","type-post","status-publish","format-standard","hentry","category-zongshu","tag-4411"],"_links":{"self":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/205372"}],"collection":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/users\/11455"}],"replies":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=205372"}],"version-history":[{"count":3,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/205372\/revisions"}],"predecessor-version":[{"id":205427,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/205372\/revisions\/205427"}],"wp:attachment":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=205372"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=205372"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=205372"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}