{"id":207631,"date":"2020-08-17T06:45:01","date_gmt":"2020-08-16T22:45:01","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=207631"},"modified":"2020-08-16T19:45:24","modified_gmt":"2020-08-16T11:45:24","slug":"%e4%b8%ad%e7%a7%91%e9%99%a2%e6%b7%b1%e5%9c%b3%e5%85%88%e8%bf%9b%e6%8a%80%e6%9c%af%e7%a0%94%e7%a9%b6%e9%99%a2adv-mater-%e6%89%98%e7%8f%a0%e5%8d%95%e6%8a%97%e5%85%b1%e8%bd%ad%e8%81%9a%e5%90%88","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=207631","title":{"rendered":"\u4e2d\u79d1\u9662\u6df1\u5733\u5148\u8fdb\u6280\u672f\u7814\u7a76\u9662Adv. Mater.:\u6258\u73e0\u5355\u6297\u5171\u8f6d\u805a\u5408\u7269\u7eb3\u7c73\u7c92\u5b50\u7528\u4e8eNIR-II\u5149\u58f0\u6210\u50cf\u4ecb\u5bfc\u7684\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u7684\u6cbb\u7597"},"content":{"rendered":"

\u3010\u80cc\u666f\u4ecb\u7ecd\u3011<\/strong><\/p>\n

\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\uff08RA\uff09\u662f\u4e00\u79cd\u9690\u533f\u7684\u81ea\u8eab\u514d\u75ab\u6027\u5173\u8282\u708e\u6027\u75be\u75c5\uff0c\u5176\u76f4\u63a5\u75c5\u56e0\u76ee\u524d\u5c1a\u4e0d\u6e05\u695a\u3002\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u7684\u7279\u70b9\u662f\u6301\u7eed\u6027\u6ed1\u819c\u708e\u548c\u8f6f\u9aa8\u4ee5\u53ca\u9aa8\u7684\u6e10\u8fdb\u6027\u7834\u574f\uff0c\u5bfc\u81f4\u5468\u56f4\u5173\u8282\u5bf9\u79f0\u6027\u75bc\u75db\u3001\u53d1\u7ea2\u548c\u80bf\u80c0\uff0c\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\u4f1a\u5bfc\u81f4\u6c38\u4e45\u6027\u6b8b\u75be\u3002\u4e0d\u5e78\u7684\u662f\uff0c\u5728\u8fd9\u79cd\u75be\u75c5\u7684\u65e9\u671f\uff0c\u60a3\u8005\u7684\u75c7\u72b6\u4e0e\u5176\u4ed6\u5f62\u5f0f\u7684\u708e\u75c7\u6027\u591a\u5173\u8282\u708e\u76f8\u4f3c\uff0c\u56e0\u6b64\u65e9\u671f\u8bca\u65ad\u548c\u6cbb\u7597\u662f\u4e00\u4e2a\u91cd\u5927\u6311\u6218\u3002\u5728\u4e34\u5e8a\u5b9e\u8df5\u4e2d\uff0c\u76ee\u524d\u7684\u8bca\u65ad\u65b9\u6cd5\u9700\u8981\u8840\u6e05\u5b66\u68c0\u67e5\u548c\u4f7f\u7528\u5e38\u89c4\u6210\u50cf\u65b9\u5f0f\uff0c\u5982\u5173\u8282\u9020\u5f71\u3001\u808c\u8089\u9aa8\u9abc\u8d85\u58f0\u548c\u78c1\u5171\u632f\u6210\u50cf\u3002\u800c\u8fd9\u4e9b\u8840\u6e05\u5b66\u65b9\u6cd5\u8d39\u65f6\uff0c\u4e14\u7ecf\u5e38\u4f1a\u51fa\u73b0\u5047\u9633\u6027\u3002\u6b64\u5916\uff0c\u8fd9\u4e9b\u6210\u50cf\u65b9\u5f0f\u7684\u4f4e\u7075\u654f\u5ea6\u9650\u5236\u4e86\u5b83\u4eec\u5728\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u540e\u671f\u89c2\u5bdf\u5173\u8282\u7ed3\u6784\u53d8\u5316\u7684\u7528\u9014\uff0c\u4e0d\u9002\u5408\u76d1\u6d4b\u6cbb\u7597\u8fdb\u5c55\u3002\u8fd1\u7ea2\u5916\uff08NIR\uff09\u8367\u5149\u6210\u50cf\u6280\u672f\u5df2\u6210\u4e3aRA\u65e9\u671f\u8bca\u65ad\u7684\u4e00\u79cd\u6709\u6548\u65b9\u6cd5\u3002\u4e0e\u524d\u9762\u63d0\u5230\u7684\u6210\u50cf\u65b9\u5f0f\u76f8\u6bd4\uff0c\u8fd9\u79cd\u6280\u672f\u53ef\u4ee5\u901a\u8fc7\u8367\u5149\u68c0\u6d4b\u7279\u5b9a\u7684\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u751f\u7269\u6807\u5fd7\u7269\u6765\u63d0\u4f9b\u5173\u8282\u7684\u7279\u5b9a\u75c5\u7406\u751f\u7406\u4fe1\u606f\u3002\u7136\u800c\uff0c\u8367\u5149\u6210\u50cf\u6709\u9650\u7684\u7ec4\u7ec7\u7a7f\u900f\u6df1\u5ea6\u963b\u788d\u4e86\u83b7\u5f97\u5b8c\u6574\u8bca\u65ad\u4fe1\u606f\u7684\u80fd\u529b\u3002\u56e0\u6b64\uff0c\u53d1\u5c55\u4e00\u79cd\u80fd\u591f\u5728\u5927\u6210\u50cf\u6df1\u5ea6\u83b7\u5f97\u7279\u5b9a\u5206\u5b50\u4fe1\u606f\u7684\u6210\u50cf\u65b9\u5f0f\u5bf9\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u7684\u8bca\u65ad\u662f\u975e\u5e38\u5fc5\u8981\u7684\u3002<\/p>\n

NIR-II\uff081000-1700nm\uff09\u5149\u58f0\uff08PA\uff09\u5206\u5b50\u6210\u50cf\uff08PMI\uff09\u662f\u4e00\u79cd\u65b0\u5174\u7684\u65e0\u521b\u8bca\u65ad\u65b9\u6cd5\uff0c\u5177\u6709\u9ad8\u4fe1\u566a\u6bd4\uff08SNR\uff09\u3001\u5927\u6210\u50cf\u6df1\u5ea6\u548c\u9ad8\u7075\u654f\u5ea6\u3002\u4e0e\u4f20\u7edf\u5149\u5b66\u6210\u50cf\u65b9\u5f0f\u76f8\u6bd4\uff0cNIR-II PMI\u5177\u6709\u8bb8\u591a\u663e\u8457\u7684\u4f18\u52bf\u3002\u800c\u89c2\u5bdf\u5230\u7684PA\u4fe1\u53f7\u662f\u7531\u5206\u5b50\u5728\u77ed\u8109\u51b2\u6fc0\u5149\u7167\u5c04\u4e0b\u5438\u6536\u5149\u800c\u4ea7\u751f\u7684\u3002\u7531\u4e8e\u58f0\u6ce2\u5728\u751f\u7269\u7ec4\u7ec7\u4e2d\u7684\u6563\u5c04\u8fdc\u5c0f\u4e8e\u5149\u7684\u6563\u5c04\uff0c\u8fd9\u79cd\u6210\u50cf\u7b56\u7565\u514b\u670d\u4e86\u5e38\u89c1\u7684\u5149\u5b66\u6269\u6563\u9650\u5236\u3002\u4e0e\u5728NIR-I\u533a\u57df\uff08650-900 nm\uff09\u4e2d\u4f7f\u7528\u6fc0\u53d1\u6ce2\u957f\u76f8\u6bd4\uff0cNIR-II\u533a\u57df\uff081000-1700 nm\uff09\u663e\u8457\u51cf\u5c11\u4e86\u5149\u6563\u5c04\u548c\u8870\u51cf\uff0c\u4e14\u6765\u81ea\u5185\u6e90\u6027\u751f\u8272\u56e2\u548c\u7ec4\u7ec7\uff08\u5982\u8840\u7ea2\u86cb\u767d\u3001\u9ed1\u8272\u7d20\u3001\u8102\u80aa\u548c\u7ec4\u7ec7\u6db2\uff09\u7684\u80cc\u666f\u5e72\u6270\u6700\u5c0f\u3002\u8fd1\u5e74\u6765\uff0c\u7f8e\u56fd\u548c\u5176\u4ed6\u56fd\u5bb6\u7684\u7814\u7a76\u8868\u660e\uff0cNIR-II PMI\u5177\u6709\u8f83\u9ad8\u7684\u4fe1\u566a\u6bd4\u3001\u7075\u654f\u5ea6\u548c\u826f\u597d\u7684\u6df1\u5ea6\u7a7f\u900f\u80fd\u529b\uff0c\u53ef\u7528\u4e8e\u8111\u8840\u7ba1\u8109\u7edc\u548c\u539f\u4f4d\u809d\u7ec6\u80de\u764c\u7b49\u75be\u75c5\u7684\u8bca\u65ad\u3002\u7136\u800c\uff0c\u8fc4\u4eca\u4e3a\u6b62\uff0cRA\u9776\u5411NIR-II PMI\u4ecd\u7136\u662f\u4e00\u4e2a\u6709\u5f85\u5f00\u53d1\u7684\u9886\u57df\uff0c\u4e3b\u8981\u539f\u56e0\u5728\u4e8e\uff1a1\uff09\u4e0e\u80bf\u7624\u76f8\u6bd4\uff0cRA\u5173\u8282\u5177\u6709\u66f4\u590d\u6742\u7684\u7ec4\u7ec7\u73af\u5883\uff0c\u4f8b\u5982\uff0cRA\u5173\u8282\u9664\u4e86\u5185\u6e90\u6027\u53d1\u8272\u56e2\u5916\uff0c\u8fd8\u6709\u8f6f\u9aa8\u548c\u9aa8\u7ec4\u7ec7\uff0c\u9700\u8981\u66f4\u6df1\u5165\u7684\u6210\u50cf\u7a7f\u900f\uff1b2\uff09RA\u5173\u8282\u6709\u5173\u8282\u8154\uff0c\u751f\u7269\u76f8\u5bb9\u6027\u4f4e\u7684\u6750\u6599\u5bb9\u6613\u505c\u6ede\uff0c\u5bfc\u81f4\u66f4\u4e25\u91cd\u7684\u5173\u8282\u635f\u4f24\u3002\u76ee\u524d\u7684NIR-II\u63a2\u9488\u8303\u56f4\u4ece\u65e0\u673a\u6750\u6599\u3001\u5c0f\u5206\u5b50\u67d3\u6599\u5230\u5171\u8f6d\u805a\u5408\u7269\u57fa\u6750\u6599\u3002\u957f\u671f\u4f7f\u7528\u65e0\u673a\u6750\u6599\u7684\u5b89\u5168\u6027\u95ee\u9898\u9650\u5236\u4e86\u5176\u53d1\u5c55\uff0c\u5c0f\u5206\u5b50\u67d3\u6599\u8868\u73b0\u51fa\u8f83\u5f3a\u7684NIR-II\u5438\u6536\u548c\u826f\u597d\u7684\u751f\u7269\u76f8\u5bb9\u6027\uff0c\u4f46\u5176\u5149\u7a33\u5b9a\u6027\u8f83\u5dee\u3002\u6709\u673a\u5171\u8f6d\u9ad8\u5206\u5b50\u6750\u6599\u7531\u4e8e\u5177\u6709\u8f83\u5f3a\u7684NIR-II\u5438\u6536\u3001\u9ad8\u7684\u5149\u7a33\u5b9a\u6027\u548c\u826f\u597d\u7684\u751f\u7269\u76f8\u5bb9\u6027\uff0c\u6b63\u9010\u6e10\u6210\u4e3aPA\u8bca\u65ad\u7684\u5019\u9009\u6750\u6599\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u6700\u8fd1\uff0c\u4e2d\u56fd\u79d1\u5b66\u9662\u6df1\u5733\u5148\u8fdb\u6280\u672f\u7814\u7a76\u9662\u5218\u6210\u6ce2\u526f\u7814\u7a76\u5458\u3001\u5f20\u9e4f\u7814\u7a76\u5458\u548c\u5357\u5f00\u5927\u5b66\u4e01\u4e39\u7814\u7a76\u5458<\/strong>\u56e2\u961f\u5408\u4f5c\u62a5\u9053\u4e86\u4e00\u79cd\u7528\u4e8eNIR-II\u5149\u58f0\u6210\u50cf\u4ecb\u5bfc\u6cbb\u7597\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u7684\u6258\u73e0\u5355\u6297\u5171\u8f6d\u805a\u5408\u7269\u7eb3\u7c73\u7c92\u5b50\u3002\u4f5c\u8005\u901a\u8fc7\u628a\u6297\u98ce\u6e7f\u9776\u5411\u836f\u7269\u6258\u73e0\u5355\u6297\uff08TCZ\uff09\u4e0e\u805a\u5408\u7269\u7eb3\u7c73\u7c92\u5b50\uff08PNPs\uff09\u7ed3\u5408\uff0c\u5f00\u53d1\u4e86\u7b2c\u4e00\u4f8b\u7528\u4e8e\u5149\u58f0\uff08PA\uff09\u6210\u50cf\u4ecb\u5bfc\u6cbb\u7597\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\uff08RA\uff09\u7684NIR-II\u6cbb\u7597\u7eb3\u7c73\u5e73\u53f0TCZ-PNPs\u3002\u5b9e\u9a8c\u7814\u7a76\u8868\u660e\uff0cTCZ-PNPs\u5177\u6709\u8f83\u5f3a\u7684NIR-II\u6d88\u5149\u7cfb\u6570\u3001\u9ad8\u7684\u5149\u7a33\u5b9a\u6027\u548c\u826f\u597d\u7684\u751f\u7269\u76f8\u5bb9\u6027\u3002NIR-IIPMI\u7684\u7ed3\u679c\u663e\u793aTCZ-PNPs\u5177\u6709\u826f\u597d\u7684\u9776\u5411\u6027\uff0c\u57283D-PA\u65ad\u5c42\u56fe\u50cf\u4e2d\u5177\u670935.8dB\u7684\u9ad8\u4fe1\u566a\u6bd4\u3002\u540c\u65f6\uff0c\u7ecf\u4e00\u4e2a\u6708\u7684\u6cbb\u7597\u548cTCZ-PNPs\u76d1\u6d4bPA\u663e\u793aRA\u88ab\u663e\u8457\u6291\u5236\u3002\u6b64\u5916\uff0cNIR-II-PMI\u5bf9RA\u5c0f\u9f20\u7684\u6cbb\u7597\u8bc4\u4ef7\u4e0e\u4e34\u5e8amicro-CT\u548c\u7ec4\u7ec7\u5b66\u5206\u6790\u4e00\u81f4\u3002\u4f5c\u8005\u8ba4\u4e3a\uff0cTCZ PNP\u8f85\u52a9\u7684NIR-II PMI\u4e3aRA\u6cbb\u7597\u3001\u6cbb\u7597\u76d1\u6d4b\u7b49\u63d0\u4f9b\u4e86\u65b0\u7684\u7b56\u7565\u3002\u76f8\u5173\u6210\u679c\u4ee5\u201cTocilizumab-Conjugated Polymer Nanoparticles for NIR-II Photoacoustic-Imaging-Guided Therapy of Rheumatoid Arthritis\u201d<\/strong>\u53d1\u8868\u4e8eAdv. Mater.<\/strong>\u671f\u520a\u4e0a\u3002<\/strong><\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe\u4e00<\/strong><\/p>\n

\"\"\uff08a\uff09TCZ-PNPs\u7528\u4e8eNIR-II\u5149\u58f0\u6210\u50cf\u548c1064 nm\u6fc0\u5149\u6cbb\u7597RA\u6a21\u578b\u5c0f\u9f20\u7684\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08b\uff09TCZ-PNPs\u7684TEM\u56fe\u50cf\uff1b<\/p>\n

\uff08c\uff09\u6c34\u6eb6\u6db2\u4e2dTCZ-PNPs\u7684DLS\u6d4b\u5b9a\uff1b<\/p>\n

\uff08d\uff09PBDTBBT\u5728CHCl3<\/sub>\u6eb6\u6db2\u4e2d\u7684\u5f52\u4e00\u5316UV-vis-NIR\u5438\u6536\u5149\u8c31\u548cTCZ-PNPs\u5728\u6c34\u4e2d\u7684\u6807\u51c6\u5316\u5438\u6536\u5149\u8c31\u3002\u63d2\u56fe\u663e\u793a\u4e86PBDTBBT\u5728CHCl3<\/sub>\u6eb6\u6db2\u4e2d\u7684\u7167\u7247\uff08i\uff09\u548c\u5728\u6c34\u4e2d\u5236\u5907\u7684TCZ PNPs\uff08ii\uff09\u3002<\/p>\n

\u56fe\u4e8c\u3001<\/strong>TCZ-PNPs<\/strong>\u7684<\/strong>NIR-IIPA<\/strong>\u7279\u6027<\/strong><\/p>\n

\"\"\uff08a\uff09TCZ-PNPs\u7684PA\u8c31\uff1b<\/p>\n

\uff08b\u3001c\uff09\u7528800\u30011064\u548c1200 nm\u6ce2\u957f\u8109\u51b2\u6fc0\u5149\u5bf91.5 cm\u9e21\u80f8\u4e0b\u4e0d\u540c\u6d53\u5ea6TCZ-PNPs\u7684\u7167\u7247\u548c\u626b\u63cfPA\u56fe\u50cf\u8fdb\u884c\u5206\u6790\uff1b<\/p>\n

\uff08d\uff09\u8be5\u56fe\u5bf9\u5e94\u4e8e\uff08c\uff09\u4e2d\u7684\u7ea2\u8272\u865a\u7ebf\uff1b<\/p>\n

\uff08e\uff09\u4e0d\u540c\u6d53\u5ea6TCZ-PNPs\u57281.5 cm\u9e21\u80f8\u4e0b\u4e0d\u540c\u6d53\u5ea6\u6fc0\u5149\u6fc0\u53d1PA\u5f3a\u5ea6\u7684\u7edf\u8ba1\u7ed3\u679c\uff1b<\/p>\n

\uff08f\uff09\uff08c\uff09\u4e2d\u4e0d\u540c\u6d53\u5ea6TCZ-PNPs PA\u56fe\u50cf\u7684\u4fe1\u566a\u6bd4\u6bd4\u8f83\uff1b<\/p>\n

\uff08g\uff09\u57281064 nm\u6fc0\u53d1\u65f6\uff0cPA\u5f3a\u5ea6\u4e0eTCZ-PNPs\u6d53\u5ea6\u7684\u51fd\u6570\u5173\u7cfb\u3002\u63d2\u56fe\u663e\u793a\u4e86\u4e0d\u540c\u6d53\u5ea6TCZ-PNPs\u6c34\u6eb6\u6db2\u57281064 nm\u6fc0\u53d1\u4e0b\u7684PA\u56fe\u50cf\uff1b<\/p>\n

\uff08h\uff091064 nm\u8109\u51b2\u6fc0\u5149\u6fc0\u53d15 min\u540ePA\u5f3a\u5ea6\u7684\u53d8\u5316\uff1b<\/p>\n

\uff08i\uff09A\/A0<\/sub>\u4e0e\u4e0d\u540c\u8f90\u7167\u65f6\u95f4\u7684\u5173\u7cfb\u56fe\u3002A\u548cA0<\/sub>\u5206\u522b\u662fICG\u548cTCZ-PNPs\u5728\u8fde\u7eed\u6fc0\u5149\u7167\u5c04\u524d\u540e808 nm\u548c1064 nm\u5904\u7684\u6700\u5927\u8fd1\u7ea2\u5916\u5438\u6536\u5f3a\u5ea6\u3002<\/p>\n

\u56fe\u4e09<\/strong><\/p>\n

\"\"\uff08a\uff09RA\u8bf1\u5bfc\u548cPA\u6210\u50cf\u5b9e\u9a8c\u8ba1\u5212\u6d41\u7a0b\u56fe\uff1b<\/p>\n

\uff08b\uff09\u6b63\u5e38\u7ec4\u548cRA\u6a21\u578b\u7ec4\u524d\u722a\u56fe\u50cf\uff1b<\/p>\n

\uff08c\uff09\u514d\u75ab\u5c0f\u9f20\u4e24\u6b21\u514d\u75ab\u540e\u7684\u4e34\u5e8a\u8bc4\u5206\uff1b<\/p>\n

\uff08d\uff09\u5206\u522b\u5728800\u30011064\u548c1200 nm\u6ce2\u957f\u8109\u51b2\u6fc0\u5149\u7167\u5c04\u4e0b\u524d\u722a\u7684\u6700\u5927\u632f\u5e45\u6295\u5f71\uff08MAP\uff09\u56fe\u50cf\u548c\u5bf9\u5e94\u7684\u7edf\u8ba1PA\u5f3a\u5ea6\uff1b<\/p>\n

\uff08f\u3001g\uff09f\uff09\u7ed8\u5236PA\/US\u56fe\u50cf\u548cg\uff09\u6b63\u5e38\u7ec4\u3001RA\u6a21\u578b\u7ec4\u548cRA\u6a21\u578b\u7ec4\u524d\u722a\u76f8\u5e94\u7684PA\u5f3a\u5ea6\u7edf\u8ba1\u503c\uff1b<\/p>\n

\uff08h\u3001i\uff09\u9759\u8109\u6ce8\u5c04TCZ-PNPs\u540eRA\u6a21\u578b\u8db3\u7684B\u8d85\u56fe\u50cf\u3002<\/p>\n

\u56fe\u56db\u3001<\/strong>\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u7684\u4f53\u5185<\/strong>PMI<\/strong>\u76d1\u6d4b\u4e0e\u6cbb\u7597<\/strong><\/p>\n

\"\"\uff08a\uff09\u6cbb\u7597\u548c\u8bca\u65ad\u7684\u5b9e\u9a8c\u8ba1\u5212\uff1b<\/p>\n

\uff08b\u3001c\uff09\u7b2c\u4e00\u6b21\u514d\u75ab\u540e\u7b2c27\u5929\u3001\u7b2c42\u5929\u548c\u7b2c57\u5929\uff0c\u6b63\u5e38\u548cTCZ-PNPs\u6cbb\u7597RA\u6a21\u578b\u7ec4\u524d\u722a\u7684\u7167\u7247\u548cPA\u56fe\u50cf\uff1b<\/p>\n

\uff08d\u3001e\uff09\u7b2c\u4e00\u6b21\u514d\u75ab\u540e\u7b2c27\u5929\u3001\u7b2c42\u5929\u548c\u7b2c57\u5929\uff0c\u6b63\u5e38\u7ec4\u548cTCZ-PNPs\u6cbb\u7597\u7ec4\u524d\u722aMAP PA\uff08d\uff09\u548cB\u626b\u63cfPA\uff08e\uff09\u5f3a\u5ea6\u7684\u7edf\u8ba1\u7ed3\u679c\uff1b<\/p>\n

\uff08f\uff09\u7b2c\u4e00\u6b21\u514d\u75ab\u540e\u7b2c27\u5929\u3001\u7b2c42\u5929\u548c\u7b2c57\u5929\uff0c\u6b63\u5e38\u7ec4\u548cTCZ-PNPs\u6cbb\u7597\u7ec4\u7684\u524d\u722a\u539a\u5ea6\u3002<\/p>\n

\u00a0<\/strong>\u56fe\u4e94<\/strong><\/p>\n

\"\"\uff08a\u3001b\uff09\u6b63\u5e38\u7ec4\u3001\u751f\u7406\u76d0\u6c34\u7ec4\u3001TCZ\u7ec4\u3001PNPs\u7ec4\u548cTCZ-PNP\u6cbb\u7597\u7ec4\u7b2c57\u5929\u524d\u722a\u6709\u4ee3\u8868\u6027\u7684MAP-PA\u56fe\u50cf\u53ca\u76f8\u5e94\u7684\u7edf\u8ba1\u6570\u636e\uff1b<\/p>\n

\uff08c\u3001d\uff09\u6b63\u5e38\u7ec4\u3001\u751f\u7406\u76d0\u6c34\u7ec4\u3001TCZ\u7ec4\u3001PNPs\u7ec4\u548cTCZ-PNPs\u6cbb\u7597\u7ec4\u7b2c57\u5929\u524d\u722a\u7684\u5178\u578b\u663e\u5faeCT\u56fe\u50cf\u548c\u9aa8\u5bc6\u5ea6\uff1b<\/p>\n

\uff08e\u3001f\uff09\u6b63\u5e38\u7ec4\u3001\u751f\u7406\u76d0\u6c34\u7ec4\u3001TCZ\u7ec4\u3001PNPs\u7ec4\u548cTCZ-PNPs\u6cbb\u7597\u7ec4\u5728\u7b2c57\u5929\u6709\u4ee3\u8868\u6027\u7684H&e\u67d3\u8272\u56fe\u50cf\u548c\u7ec4\u7ec7\u5b66\u8bc4\u5206\uff1b<\/p>\n

\uff08g\uff0ch\uff09\u6b63\u5e38\u7ec4\u3001\u751f\u7406\u76d0\u6c34\u7ec4\u3001TCZ\u7ec4\u3001PNPs\u7ec4\u548cTCZ-PNPs\u6cbb\u7597\u7ec4\u7b2c57\u5929\u7684\u4ee3\u8868\u6027\u756a\u7ea2-o\u67d3\u8272\u56fe\u50cf\u548c\u8f6f\u9aa8\u542b\u91cf\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

\u7efc\u4e0a\u6240\u8ff0\uff0c\u4f5c\u8005\u5f00\u53d1\u4e86\u4e00\u79cd\u57fa\u4e8eTCZ\u7684\u5171\u8f6d\u805a\u5408\u7269\u7eb3\u7c73\u7c92\u5b50TCZ-PNPs\uff0c\u5e76\u5c06\u5176\u7528\u4e8eRA\u7684\u8bca\u65ad\u548c\u6cbb\u7597\u76d1\u6d4b\u3002\u4f5c\u8005\u9996\u5148\u5c06\u5177\u6709RA\u6cbb\u7597\u548c\u9776\u5411\u529f\u80fd\u7684\u5355\u514b\u9686\u6297\u4f53tocilizumab\uff08TCZ\uff09\u4e0ePNPs\u5076\u8054\uff0c\u5236\u5907\u4e86\u7528\u4e8eRA\u9776\u5411\u5e76\u884c\u6210\u50cf\u548c\u6cbb\u7597\u7684\u96c6\u6210\u7684TCZPNPs\u3002\u540c\u65f6\uff0c\u4f5c\u8005\u91c7\u7528\u80f6\u539f\u8bf1\u5bfc\u5173\u8282\u708e\uff08CIA\uff09\u52a8\u7269\u6a21\u578b\u8fdb\u884cRA\u7684\u4f53\u5185\u8bca\u65ad\u3002\u7531\u4e8eTCZ-PNPs\u5177\u6709\u826f\u597d\u7684\u5149\u751f\u7406\u7a33\u5b9a\u6027\u3001\u5927\u7684\u5438\u6536\u7cfb\u6570\u3001\u826f\u597d\u7684\u751f\u7269\u76f8\u5bb9\u6027\u548c\u7406\u60f3\u7684PA\u7279\u6027\uff0c\u53ef\u4ee5\u5728\u4f53\u5185\u8fdb\u884c\u6df1\u90e8\u7ec4\u7ec7PA\u6210\u50cf\u3002\u4f5c\u8005\u901a\u8fc7\u7ed3\u5408\u5b9a\u5236\u7684PA\u4e09\u7ef4\u65ad\u5c42\u6210\u50cf\u4eea\uff0c\u5b9e\u73b0\u4e86NIR-II PA\u5206\u5b50\u6210\u50cf\u5f15\u5bfc\u4e0b\u7684RA\u6cbb\u7597\uff0c\u5176\u5177\u6709\u9ad8\u7075\u654f\u5ea6\u3001\u9ad8\u7279\u5f02\u6027\u548c\u9ad8\u4fe1\u566a\u6bd4\u3002\u7ecf\u8fc7\u957f\u65f6\u95f4\u7684\u6cbb\u7597\u548c\u4f7f\u7528\u5927\u6837\u672c\u91cf\uff0840\u53ea\u5c0f\u9f20\uff09\u7684TCZ-PNPs\u5bf9RA\u8fdb\u884c\u6cbb\u7597\u548cNIR-II 3D-PA\u76d1\u6d4b\u53ef\u4ee5\u663e\u8457\u6291\u5236RA\u3002\u6b64\u5916\uff0c\u4f5c\u8005\u53d1\u73b0TCZ-PNPs\u5177\u6709\u8f83\u9ad8\u7684\u708e\u75c7\u7279\u5f02\u6027\uff0c\u5728\u9274\u522b\u65e9\u671f\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u4e0e\u5176\u4ed6\u708e\u75c7\u6027\u75be\u75c5\u65b9\u9762\u6709\u5f88\u5927\u4f18\u52bf\u3002\u5728\u5bf9RA\u5173\u8282\u7ec4\u7ec7\u8fdb\u884cNIR-II PMI\u663e\u793a\uff0c\u53ef\u4ee5\u6e05\u695a\u5730\u663e\u793a\u80bf\u80c0\u548c\u8f6f\u9aa8\u7ec4\u7ec7\uff0c\u8fd9\u8868\u660e\u5176\u5728\u65e0\u521b\u76d1\u6d4bRA\u75be\u75c5\u8fdb\u5c55\u65b9\u9762\u7684\u8bca\u65ad\u6f5c\u529b\u3002\u8fdb\u4e00\u6b65\u7684TCZ-PNPs\u8bca\u65ad\u7ed3\u679c\u5747\u7ecf\u4e34\u5e8a\u5e94\u7528\u7684\u663e\u5faeCT\u6210\u50cf\u548c\u7ec4\u7ec7\u5b66\u5206\u6790\u8bc1\u5b9e\uff1aTCZ-PNPs\u514b\u670d\u4e86\u5355\u6297\u836f\u4ee3\u52a8\u529b\u5b66\u5dee\u7684\u7f3a\u70b9\uff0c\u663e\u793a\u51fa\u6bd4\u6e38\u79bbTCZ\u66f4\u6709\u6548\u7684\u6cbb\u7597\u6548\u679c\u3002\u6cbb\u75971\u4e2a\u6708\u540e\uff0c\u5c0f\u9f20RA\u7ec4\u7ec7\u51fa\u73b0\u8d85\u4f4ePA\u5f3a\u5ea6\uff0c\u4e0e\u6b63\u5e38\u5c0f\u9f20\u7684PA\u5f3a\u5ea6\u76f8\u5f53\u3002\u6700\u91cd\u8981\u7684\u662f\uff0c\u8fd9\u662f\u7b2c\u4e00\u4f8b\u4f7f\u7528NIR-II PMI\u540c\u65f6\u8bca\u65ad\u548c\u6cbb\u7597\u76d1\u6d4bRA\u7684\u4f8b\u5b50\u3002\u56e0\u6b64\uff0c\u4f5c\u8005\u8ba4\u4e3aTCZ-PNPs\u5728\u672a\u6765\u7684\u4e34\u5e8a\u8f6c\u5316\u4e2d\u5177\u6709\u91cd\u8981\u7684\u5e94\u7528\u6f5c\u529b\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aTocilizumab\u2010Conjugated Polymer Nanoparticles for NIR\u2010II Photoacoustic\u2010Imaging\u2010Guided Therapy of Rheumatoid Arthritis<\/a>\uff08Adv. Mater.<\/em> 2020<\/strong>, 2003399\uff09<\/p>\n

\u672c\u6587\u7531\u6211\u4ea6\u662f\u884c\u4eba\u7f16\u8bd1\u3002<\/p>\n

\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1\uff1atougao@cailiaoren.com.<\/a><\/p>\n

\u6295\u7a3f\u4ee5\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1acailiaorenvip.<\/p>\n","protected":false},"excerpt":{"rendered":"

\u3010\u80cc\u666f\u4ecb\u7ecd\u3011 \u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\uff08RA\uff09\u662f\u4e00\u79cd\u9690\u533f\u7684\u81ea\u8eab\u514d\u75ab\u6027\u5173\u8282\u708e\u6027\u75be\u75c5\uff0c\u5176\u76f4\u63a5\u75c5\u56e0\u76ee\u524d\u5c1a\u4e0d\u6e05\u695a\u3002\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u7684\u7279\u70b9\u662f\u6301\u7eed\u6027\u6ed1\u819c\u708e\u548c\u8f6f\u9aa8\u4ee5\u53ca\u9aa8\u7684\u6e10\u8fdb\u6027\u7834\u574f\uff0c\u5bfc\u81f4…<\/p>\n","protected":false},"author":11455,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215],"tags":[4447],"class_list":["post-207631","post","type-post","status-publish","format-standard","hentry","category-jiedu","tag-nir-ii"],"_links":{"self":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/207631"}],"collection":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/users\/11455"}],"replies":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=207631"}],"version-history":[{"count":3,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/207631\/revisions"}],"predecessor-version":[{"id":207655,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/207631\/revisions\/207655"}],"wp:attachment":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=207631"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=207631"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=207631"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}