{"id":209440,"date":"2020-09-20T06:46:14","date_gmt":"2020-09-19T22:46:14","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=209440"},"modified":"2020-09-19T20:46:36","modified_gmt":"2020-09-19T12:46:36","slug":"%e6%9e%97%e6%81%92%e4%bc%9f%e5%9b%a2%e9%98%9fangew-chem-int-ed-%ef%bc%9a%e8%82%bf%e7%98%a4%e5%be%ae%e7%8e%af%e5%a2%83%e5%93%8d%e5%ba%94%e5%9e%8b%e7%a2%b3%e7%82%b9-cu2%e7%a6%bb%e5%ad%90%e7%ba%b3","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=209440","title":{"rendered":"\u6797\u6052\u4f1f\u56e2\u961fAngew. Chem. Int. Ed.\uff1a\u80bf\u7624\u5fae\u73af\u5883\u54cd\u5e94\u578b\u78b3\u70b9-Cu2+\u79bb\u5b50\u7eb3\u7c73\u7ec4\u88c5\u4f53\u7528\u4e8e\u6210\u50cf\u53ca\u534f\u540c\u6cbb\u7597"},"content":{"rendered":"

\u3010\u7814\u7a76\u80cc\u666f\u3011<\/strong><\/p>\n

\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u4ee5\u65b0\u751f\u8840\u7ba1\u3001\u5f02\u5e38\u7684\u751f\u7269\u5408\u6210\u4e2d\u95f4\u4f53\u3001\u5f31\u9178\u73af\u5883\u3001\u4e4f\u6c27\u4e3a\u4e3b\u8981\u7279\u5f81\uff0c\u4e3a\u80bf\u7624\u7684\u4ea7\u751f\u53ca\u53d1\u5c55\u63d0\u4f9b\u4e86\u6761\u4ef6\uff0c\u5e76\u4e14\u4e0e\u80bf\u7624\u7684\u4fb5\u88ad\u6027\u8f6c\u79fb\u53ca\u591a\u836f\u8010\u836f\u6027\u7684\u4ea7\u751f\u5bc6\u5207\u76f8\u5173\u3002\u6b64\u5916\uff0cTME\u7684\u7279\u5f02\u6027\u4e5f\u4e3a\u764c\u75c7\u6cbb\u7597\u63d0\u4f9b\u4e86\u6709\u6548\u9776\u70b9\uff0c\u56e0\u800c\u5728\u63a2\u7d22\u5168\u65b0\u6297\u764c\u7b56\u7565\u7684\u8fc7\u7a0b\u4e2d\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\u3002\u57fa\u4e8e\u7eb3\u7c73\u6750\u6599\u6784\u5efa\u7684\u9488\u5bf9\u5185\u6e90\u6027TME\u53ca\u5916\u6e90\u523a\u6fc0\uff08\u5149\/\u78c1\u573a\/\u8d85\u58f0\u6ce2\u7b49\uff09\u54cd\u5e94\u7684\u8bca\u7597\u5e73\u53f0\u5177\u6709\u9776\u5411\u6cbb\u7597\u53ca\u964d\u4f4e\u526f\u4f5c\u7528\u7684\u4f18\u52bf\u3002\u78b3\u70b9\uff08carbon dots, CDs\uff09\u4f5c\u4e3a\u4e00\u7c7b\u65b0\u578b\u8367\u5149\u7eb3\u7c73\u6750\u6599\uff0c\u51ed\u501f\u7a33\u5b9a\u7684\u5149\u5b66\u6027\u80fd\u3001\u4f18\u5f02\u7684\u751f\u7269\u76f8\u5bb9\u6027\u3001\u6613\u4e8e\u4fee\u9970\u6027\u53ca\u6f5c\u5728\u7684\u5149\u70ed\uff08PTT\uff09\/\u5149\u52a8\u529b\uff08PDT\uff09\u6cbb\u7597\u6027\u80fd\u800c\u5728\u80bf\u7624\u8bca\u7597\u9886\u57df\u5c55\u73b0\u51fa\u5de8\u5927\u7684\u5e94\u7528\u6f5c\u529b\u3002\u76ee\u524d\uff0c\u9650\u5236CDs\u5728\u8be5\u9886\u57df\u5e94\u7528\u7684\u4e3b\u8981\u56e0\u7d20\u5305\u62ec\uff1a1\uff09\u5728\u80bf\u7624\u7ec4\u7ec7\u7684\u7d2f\u79ef\u4e0d\u5145\u5206\uff08\u53d7\u9650\u4e8e\u5c0f\u5c3a\u5bf8\u6027\uff09\uff1b2\uff09\u7f3a\u4e4f\u9488\u5bf9\u80bf\u7624\u5fae\u73af\u5883\u7279\u5f02\u6027\u8bc6\u522b\u3001\u54cd\u5e94\u7684\u80fd\u529b\uff1b3\uff09\u5355\u4e00\u6a21\u5f0f\u7684\u6cbb\u7597\u6548\u7387\u6709\u9650\uff0c\u90e8\u5206\u63d0\u9ad8\u6548\u7387\u7684\u65b9\u6cd5\u4f34\u968f\u7740\u63d0\u5347\u6cbb\u7597\u526f\u4f5c\u7528\u7684\u98ce\u9669\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u4e2d\u79d1\u9662\u5b81\u6ce2\u6750\u6599\u6240<\/strong>\/<\/strong>\u6c5f\u5357\u5927\u5b66\u6797\u6052\u4f1f\u7814\u7a76\u5458\uff08\u6559\u6388\uff09<\/strong>\u7b49\u4eba\u901a\u8fc7\u7b80\u4fbf\u7ec4\u88c5\u5149\u654f\u5242\uff08Ce6\uff09\u4fee\u9970\u7684\u8367\u5149\u78b3\u70b9\uff08CDs-Ce6\uff09\u548cCu2+<\/sup>\u7684\u65b9\u6cd5\uff0c\u6784\u5efa\u4e86TME\u667a\u80fd\u54cd\u5e94\u578b\u7eb3\u7c73\u5e73\u53f0\uff0c\u53ef\u7528\u4e8e\u8367\u5149\u6210\u50cf\u4ecb\u5bfc\u4e0b\u7684\u534f\u540c\u6cbb\u7597\u3002\u57fa\u4e8e\u91d1\u5c5e\u79bb\u5b50\u4e0eCDs-Ce6\u7684\u7edc\u5408\u6548\u5e94\u6240\u5236\u5907\u7684\u7eb3\u7c73\u7ec4\u88c5\u4f53\uff08Cu\/CC NPs\uff09\u5c55\u73b0\u51fa\u66f4\u9002\u4e8e\u8840\u6db2\u957f\u5faa\u73af\u7684\u5c3a\u5bf8\uff0847.5 nm\uff09\uff0c\u5e76\u4e14\u8868\u73b0\u51fa\u731d\u706d\u7684\u8367\u5149\u4e0e\u5149\u654f\u6027\u80fd\u3002\u5f53\u5176\u66b4\u9732\u4e8eTME\u7684\u523a\u6fc0\u4e2d\uff0cCu2+<\/sup>\u79bb\u5b50\u4e00\u65b9\u9762\u80fd\u591f\u4e0e\u8fc7\u8868\u8fbe\u7684\u53cc\u6c27\u6c34\uff08H2<\/sub>O2<\/sub>\uff09\u53cd\u5e94\u4ea7\u751f\u5177\u6709\u764c\u7ec6\u80de\u6740\u4f24\u529b\u7684\u7f9f\u57fa\u81ea\u7531\u57fa\uff08\u2022OH\uff09\u53d1\u6325\u5316\u5b66\u52a8\u529b\u5b66\u6cbb\u7597\uff08CDT\uff09\u529f\u6548\uff0c\u53e6\u4e00\u65b9\u9762\u80fd\u591f\u548c\u80bf\u7624\u7ec4\u7ec7\u4e2d\u9ad8\u6d53\u5ea6\u7684\u8c37\u80f1\u7518\u80bd\uff08GSH\uff09\u53cd\u5e94\uff0c\u901a\u8fc7\u6d88\u8017GSH\u8fbe\u5230\u589e\u5f3a\u7ec6\u80de\u5185\u6d3b\u6027\u6c27\uff08ROS\uff09\u4ea7\u751f\uff0c\u653e\u5927\u6c27\u5316\u5e94\u6fc0\u7684\u76ee\u7684\u3002\u540c\u65f6\uff0cCu2+<\/sup>\u5728\u53cd\u5e94\u4e2d\u88ab\u8fd8\u539f\u4e3aCu+<\/sup>\uff0c\u4e0eCDs-Ce6\u7684\u7edc\u5408\u80fd\u529b\u51cf\u5f31\uff0c\u5728\u80bf\u7624\u5fae\u9178\u73af\u5883\u7684\u4f5c\u7528\u4e0b\u8bf1\u5bfc\u7ec4\u88c5\u4f53\u53d1\u751f\u89e3\u7ec4\u88c5\uff0c\u540c\u65f6\u4f34\u968f\u7740\u8367\u5149\u6027\u80fd\u4e0e\u5149\u654f\u6027\u80fd\u7684\u6709\u6548\u6062\u590d\u53ca\u529f\u80fd\u7ec4\u5206\u5411\u80bf\u7624\u6df1\u7ec4\u7ec7\u7684\u6269\u6563\u3002\u6700\u540e\uff0c\u901a\u8fc7\u7ec6\u80de\u53ca\u52a8\u7269\u5c42\u9762\u7684\u5b9e\u9a8c\u8bc1\u660e\u4e86Cu\/CC NPs\u4f18\u5f02\u7684\u534f\u540c\u6cbb\u7597\u6548\u679c\uff08PDT\u3001PTT\u53ca\u5149\u70ed\u589e\u5f3a\u7684CDT\uff09\u3002\u8be5\u6587\u7ae0\u8fd1\u65e5\u4ee5\u9898\u4e3a\u201cTumor Microenvironment Stimuli-Responsive Fluorescence Imaging and Synergistic Cancer Therapy by Carbon- Dot-Cu2+<\/sup> Nanoassemblies<\/strong>\u201d\u53d1\u8868\u5728\u77e5\u540d\u671f\u520aAngew. Chem. Int. Ed.<\/strong>\u4e0a<\/strong>\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe\u4e00\u3001<\/strong>Cu\/CC NPs<\/strong>\u7684\u5236\u5907\u53ca\u8868\u5f81<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a-d\uff09Cu\/CC NPs\u7684TEM\uff0cHR-TEM\uff0c\u5143\u7d20mapping\u56fe\u50cf\u4ee5\u53ca\u6c34\u5408\u52a8\u529b\u5b66\u76f4\u5f84\u3002<\/p>\n

\uff08e\uff09CDs, CDs-Ce6\u4ee5\u53caCu\/CC NPs\u7684\u7ea2\u5916\u5149\u8c31\u3002<\/p>\n

\uff08f-g\uff09Cu\/CC NPs\u7684XPS\u5168\u8c31\u4ee5\u53caCu 2p\u8c31\u3002<\/p>\n

\uff08h\uff09CDs, CDs-Ce6, Cu\/CC NPs\u4ee5\u53caCe6\u7684\u7d2b\u5916-\u53ef\u89c1\u5149\u5438\u6536\u5149\u8c31\u3002<\/p>\n

\uff08i\uff09550 nm\u6fc0\u53d1\u4e0bCDs-Ce6\u548cCu\/CC NPs\u7684\u8367\u5149\u5149\u8c31\u3002<\/p>\n

\u56fe\u4e8c\u3001<\/strong>Cu\/CC NPs<\/strong>\u7684\u5185\u6e90\u523a\u6fc0\u54cd\u5e94\u6027<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09\u968fGSH\u7684\u52a0\u5165\uff0cCu\/CC NPs\u7684\u8367\u5149\u5f3a\u5ea6\u53d8\u5316\u3002<\/p>\n

\uff08b\uff09\u7a7a\u767d\u7ec4\u3001CDs-Ce6\u548cCu\/CC NPs\u5206\u522b\u5bf9GSH\u7684\u6d88\u8017\u80fd\u529b\u8bc4\u4f30\u3002<\/p>\n

\uff08c\uff09Cu2+<\/sup>\u4e0eH2<\/sub>O2<\/sub>\u53cd\u5e94\u7684\u65b9\u7a0b\u5f0f\u3002<\/p>\n

\uff08d\uff09\u5bf9\u7167\u7ec4\u3001Cu\/CC NP\u5728\u53cc\u6c27\u6c34\u5b58\u5728\u6761\u4ef6\u4e0b\u4e0e\u2022OH\u68c0\u6d4b\u63a2\u9488\uff08TA\uff09\u53cd\u5e94\u7684\u63a2\u9488\u8367\u5149\u5149\u8c31\u3002<\/p>\n

\u56fe\u4e09\u3001<\/strong>Cu\/CC NPs<\/strong>\u7684\u5916\u6e90\u523a\u6fc0\u54cd\u5e94\u6027<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09\u5728660 nm\u6fc0\u5149\u8f90\u7167\u4e0b\uff0c\u4e0d\u540c\u6d53\u5ea6\uff0850\u81f3200 \u03bcg mL-1<\/sup>\uff09\u7684Cu\/CC NPs\u6eb6\u6db2\u6e29\u5ea6\u968f\u65f6\u95f4\u7684\u53d8\u5316\u66f2\u7ebf\u3002<\/p>\n

\uff08b\uff09\u4e0d\u540c\u6d53\u5ea6\u7684Cu\/CC NPs\u6eb6\u6db2\uff0850\u3001100 \u03bcg mL-1<\/sup>\uff09\u5728\u6709\/\u65e0\u6fc0\u5149\u8f90\u7167\u6761\u4ef6\u4e0b\u4e0e\u2022OH\u68c0\u6d4b\u63a2\u9488\uff08TA\uff09\u53cd\u5e94\u7684\u63a2\u9488\u8367\u5149\u5f3a\u5ea6\u7684\u6bd4\u503c\u3002<\/p>\n

\uff08c\uff09\u5728660 nm\u6fc0\u5149\u8f90\u7167\u4e0b\uff0c\u6709\/\u65e0GSH\u52a0\u5165\u65f6\uff0cCu\/CC NPs\u6eb6\u6db2\u4e0e\u5355\u7ebf\u6001\u6c27\u68c0\u6d4b\u63a2\u9488\uff08SOSG\uff09\u53cd\u5e94\u7684\u63a2\u9488\u8367\u5149\u5f3a\u5ea6\u968f\u8f90\u7167\u65f6\u95f4\u7684\u53d8\u5316\u3002<\/p>\n

\uff08d\uff09\u5728660 nm\u6fc0\u5149\u8f90\u71675 min\u540e\uff0cSOSG\u5206\u522b\u4e0eCu\/CC NPs\u548cCDs-Ce6\u6eb6\u6db2\u53cd\u5e94\u7684\u63a2\u9488\u8367\u5149\u5f3a\u5ea6\u53d8\u5316\u3002<\/p>\n

\u56fe\u56db\u3001\u4f53\u5916\u8367\u5149\u6210\u50cf\u4e0e\u534f\u540c\u6cbb\u7597<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09\u7528Cu\/CC NPs\u548cHoechst\u5904\u7406\u76844T1\u7ec6\u80de\u7684CLSM\u56fe\u50cf\u3002<\/p>\n

\uff08b\uff09\u6709\/\u65e0ALA\u9884\u5904\u7406\u76844T1\u7ec6\u80de\u4e0eCu\/CC NPs\u5b75\u80b2\u7684CLSM\u56fe\u50cf\u53ca\u8367\u5149\u5f3a\u5ea6\u5b9a\u91cf\u7ed3\u679c\u3002<\/p>\n

\uff08c\uff09\u4e0d\u540c\u6d53\u5ea6\u7684Cu\/CC NPs\u4e0e\u6b63\u5e38\u7ec6\u80de\uff08MRC-5\uff09\u53ca\u764c\u7ec6\u80de\uff08A549\u548c4T1\uff09\u5171\u5b75\u80b224\u5c0f\u65f6\u540e\u7684\u7ec6\u80de\u5b58\u6d3b\u7387\u3002<\/p>\n

\uff08d\uff094T1\u7ec6\u80de\u4e0ePBS\u3001H2<\/sub>O2<\/sub>\u3001Cu\/CC NPs\u548cCu\/CC NPs\u4e0eH2<\/sub>O2<\/sub>\u7684\u6df7\u5408\u6eb6\u6db2\u5b75\u80b2\u540e\u7684\u6d3b\/\u6b7b\u7ec6\u80de\u67d3\u8272\u56fe\u50cf\u3002<\/p>\n

\uff08e\uff09\u4e0e\u4e0d\u540c\u6d53\u5ea6\u7684Cu\/CC NPs\u5b75\u80b2\u76844T1\u7ec6\u80de\u5728\u4e0d\u540c\u7684\u6fc0\u5149\u8f90\u7167\u6761\u4ef6\u4e0b\u7684\u7ec6\u80de\u5b58\u6d3b\u7387\u3002<\/p>\n

\uff08f\uff09\u4e0eDCFH-DA\u5b75\u80b2\u76844T1\u7ec6\u80de\uff0c\u5206\u522b\u7ecf\u8fc7PBS\uff0cCu\/CC NP\u548cCu\/CC NPs+\u6fc0\u5149\u5904\u7406\u7684CLSM\u56fe\u50cf\u53ca\u8367\u5149\u5f3a\u5ea6\u5b9a\u91cf\u7ed3\u679c\u3002<\/p>\n

\u56fe\u4e94\u3001\u4f53\u5185\u6210\u50cf\u4e0e\u6297\u80bf\u7624\u4f5c\u7528<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09\u5c3e\u9759\u8109\u6ce8\u5c04\u6750\u6599\u540e\u4e0d\u540c\u65f6\u95f4\u70b9\u5c0f\u9f20\u4e3b\u8981\u5668\u5b98\u548c\u80bf\u7624\u7684\u8367\u5149\u56fe\u50cf\u3002<\/p>\n

\uff08b\uff09\u4e0d\u540c\u5904\u7406\u7ec4\u8377\u7624\u5c0f\u9f20\u6fc0\u5149\u8f90\u716710\u5206\u949f\u524d\u540e\u7684\u70ed\u6210\u50cf\u56fe\u3002<\/p>\n

\uff08c\uff09b\u56fe\u5bf9\u5e94\u7684\u5c0f\u9f20\u80bf\u7624\u90e8\u4f4d\u6e29\u5ea6\u968f\u65f6\u95f4\u53d8\u5316\u66f2\u7ebf\u3002<\/p>\n

\uff08d\uff09\u76d1\u6d4b\u671f\u5185\u4e0d\u540c\u7ec4\u522b\u8377\u7624\u5c0f\u9f20\u7684\u80bf\u7624\u4f53\u79ef\u53d8\u5316\u60c5\u51b5\u3002<\/p>\n

\uff08e\uff09\u7b2c1\u5929\u548c\u7b2c14\u5929\u4e0d\u540c\u7ec4\u522b\u4ee3\u8868\u6027\u5c0f\u9f20\u7167\u7247\uff0c\u4ee5\u53ca\u7b2c14\u5929\u727a\u7272\u5c0f\u9f20\u6536\u96c6\u7684\u80bf\u7624\u7ec4\u7ec7\u7684H\uff06E\u67d3\u8272\u5207\u7247\u3002<\/p>\n

\u3010\u7ed3\u8bba\u5c55\u671b\u3011<\/strong><\/p>\n

\u672c\u7814\u7a76\u901a\u8fc7CDs-Ce6\u548cCu2+<\/sup>\u79bb\u5b50\u7684\u7b80\u4fbf\u7ec4\u88c5\uff0c\u6784\u5efa\u4e86\u5177\u6709TME\u53ca\u5916\u5149\u6e90\u523a\u6fc0\u54cd\u5e94\u6027\u7684\u667a\u80fd\u80bf\u7624\u8bca\u7597\u5e73\u53f0\uff0c\u5c55\u73b0\u51faTME\u7279\u5f02\u6027\u6fc0\u6d3b\u7684FL\u6210\u50cf\u3001\u5149\u654f\u6027\u80fd\u4e0e\u89e3\u7ec4\u88c5\u6027\u80fd\uff0c\u7ed3\u5408PTT\u3001PDT\u548c\u5149\u70ed\u589e\u5f3a\u7684CDT\u534f\u540c\u6cbb\u7597\u6a21\u5f0f\uff0c\u5728\u63d0\u9ad8\u80bf\u7624\u6cbb\u7597\u6548\u7387\u7684\u540c\u65f6\u6709\u6548\u964d\u4f4e\u4e86\u526f\u4f5c\u7528\u3002\u672c\u7814\u7a76\u4e00\u65b9\u9762\u9488\u5bf9CDs\u5728\u80bf\u7624\u751f\u7269\u533b\u5b66\u4e2d\u7684\u5e94\u7528\uff0c\u63d0\u51fa\u4e86\u89e3\u51b3CDs\u80bf\u7624\u7d2f\u79ef\u4e0d\u5145\u5206\u3001\u7f3a\u4e4fTME\u7279\u5f02\u6027\u8bc6\u522b\/\u54cd\u5e94\u80fd\u529b\u53ca\u5355\u4e00\u6cbb\u7597\u6a21\u5f0f\u9650\u5236\u7684\u95ee\u9898\u7684\u7b56\u7565\uff0c\u53e6\u4e00\u65b9\u9762\u4e5f\u62d3\u5c55\u4e86\u91d1\u5c5e\u79bb\u5b50\u5728\u80bf\u7624\u6cbb\u7597\u4e2d\u7684\u6f5c\u5728\u4ef7\u503c\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aTumor Microenvironment Stimuli-Responsive Fluorescence Imaging and Synergistic Cancer Therapy by Carbon\u2010Dot\u2013Cu2+ Nanoassemblies<\/a> (Angew. Chem. Int. Ed.<\/em>, 2020<\/strong>, DOI: 10.1002\/anie. 202007786)<\/p>\n

\u56e2\u961f\u4ecb\u7ecd\uff1a<\/strong><\/p>\n

\u56e2\u961f\u8d1f\u8d23\u4eba\uff1a\u6797\u6052\u4f1f\uff0c\u6c5f\u5357\u5927\u5b66\u6559\u6388\uff0c\u535a\u58eb\u751f\u5bfc\u5e08\uff0c\u4e2d\u79d1\u9662\u201c\u767e\u4eba\u8ba1\u5212\u201d\u5165\u9009\u8005\uff0c\u4e3b\u8981\u4ece\u4e8b\u65b0\u578b\u53d1\u5149\u6750\u6599\u5236\u5907\u4e0e\u5e94\u7528\u53ca\u98df\u54c1\u5b89\u5168\u3001\u75be\u75c5\u8bca\u7597\u76f8\u5173\u7684\u7814\u7a76\u5de5\u4f5c\u3002\u56e2\u961f\u5728\u5148\u8fdb\u6750\u6599(Advanced Materials)\u3001\u5fb7\u56fd\u5e94\u7528\u5316\u5b66\uff08Angewandte Chemie\uff09\u3001\u7f8e\u56fd\u5316\u5b66\u4f1a\u5fd7\uff08Journal of the American Chemical Society\uff09\u7b49\u671f\u520a\u53d1\u8868SCI\u8bba\u658750\u4f59\u7bc7\uff08\u5176\u4e2dSCI\u9ad8\u88ab\u5f15\u8bba\u65877\u7bc7\uff09\uff0c\u88ab\u5f15\u75283400\u4f59\u6b21\u3002<\/p>\n

\u56e2\u961f\u5728\u8be5\u9886\u57df\u5de5\u4f5c\u6c47\u603b\uff1a<\/strong><\/p>\n

\u56e2\u961f\u8fd1\u5e74\u6765\u5728\u78b3\u57fa\u8367\u5149\u7eb3\u7c73\u6750\u6599\u7684\u5f00\u53d1\u53ca\u5176\u5728\u751f\u7269\u533b\u5b66\u9886\u57df\u7684\u5e94\u7528\u7814\u7a76\u4e2d\u53d6\u5f97\u7684\u4e3b\u8981\u6210\u679c\u603b\u7ed3\u5982\u4e0b\uff1a1\uff09\u6784\u5efa\u4e86\u57fa\u4e8e\u78b3\u70b9\u7684\u7ec6\u80de\u5668\u9776\u5411\u6210\u50cf\u53ca\u591a\u79cd\u751f\u7269\u5c0f\u5206\u5b50\u548c\u79bb\u5b50\uff08\u8c37\u80f1\u7518\u80bd\u3001\u534a\u80f1\u6c28\u9178\u3001\u6297\u574f\u8840\u9178\u3001\u78f7\u9178\u6839\u3001\u8fc7\u6c27\u4e9a\u785d\u9178\u6839\u7b49\uff09\u63a2\u9488\uff08Chem. Commun<\/em>. 2015, 51, 12748; Biosens. Bioelectron<\/em>. 2017, 90, 501; Carbon<\/em> 2017, 124, 342; Biosens. Bioelectron<\/em>. 2017, 97, 150; Anal. Chm<\/em>. 2017, 89, 5542; Nanoscale<\/em> 2018, 10, 1532\uff1bNanoscale<\/em> 2018, 10, 17834; Analyst<\/em>, 2019, 144, 468\uff09\uff1b2) \u6784\u5efa\u4e86\u591a\u7c7b\u57fa\u4e8e\u78b3\u70b9\u7684\u7eb3\u7c73\u590d\u5408\u80bf\u7624\u8bca\u7597\u6750\u6599\uff08\u4f8b\u5982\uff1a\u78b3\u70b9-\u5149\u654f\u5242 \uff08ACS Appl. Mater. Interfaces <\/em>2019, 11<\/em>, 5791\uff09\uff0c\u78b3\u70b9-\u4ecb\u5b54\u7845\uff08Nano-Micro Lett.<\/em> 2019, 11<\/em>, 32\uff09\uff0c\u78b3\u70b9-\u91d1\u5c5e\u79bb\u5b50\u7b49\uff09\uff0c\u57fa\u4e8e\u590d\u5408\u5355\u5143\u7684\u591a\u6a21\u6001\u6210\u50cf\u3001\u80bf\u7624\u5fae\u73af\u5883\u54cd\u5e94\u3001\u50ac\u5316\u53ca\u5149\u70ed\/\u5149\u52a8\u529b\u529f\u80fd\u5b9e\u73b0\u4e86\u5728\u7ec6\u80de\u53ca\u5c0f\u52a8\u7269\u5c42\u9762\u6210\u50cf\u4ecb\u5bfc\u4e0b\u7684\u80bf\u7624\u6cbb\u7597\u3002<\/p>\n

\u4e0e\u8be5\u5de5\u4f5c\u76f8\u5173\u4f18\u8d28\u6587\u732e\u63a8\u8350\uff1a<\/strong><\/p>\n

1\uff09Zhao, S.; Sun, S.*; Jiang, K.; Wang, Y.; Liu, Y.; Wu, S.; Li, Z.; Shu, Q.*; Lin, H.*, In Situ Synthesis of Fluorescent Mesoporous Silica\u2013Carbon Dot Nanohybrids Featuring Folate Receptor-Overexpressing Cancer Cell Targeting and Drug Delivery. Nano-Micro Lett.<\/em><\/strong> 2019<\/strong>, 11<\/em>, 32.<\/p>\n

2\uff09Sun, S., Chen, J., Jiang, k., Tang, Z., Wang, Y., Li, Z., Liu, C.*, Wu, A., Lin, H.*, Ce6-modified Carbon Dots for Multimodal-Imaging-Guided and Single-NIR-Laser-Triggered Photothermal\/ Photodynamic Synergistic Cancer Therapy by Reduced Irradiation Power. ACS Appl. Mater. Interfaces <\/em>2019<\/strong>, 11<\/em>, 5791. (IF=8.758, JCR Q1)<\/p>\n

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