{"id":214957,"date":"2020-12-22T06:05:36","date_gmt":"2020-12-21T22:05:36","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=214957"},"modified":"2020-12-21T22:05:50","modified_gmt":"2020-12-21T14:05:50","slug":"acc-chem-res-%e7%bb%bc%e8%bf%b0%ef%bc%9a%e8%87%aa%e7%bb%84%e8%a3%85%e8%b6%85%e5%88%86%e5%ad%90%e6%a0%91%e5%bd%a2%e5%88%86%e5%ad%90%e7%94%a8%e4%ba%8e%e7%94%9f%e7%89%a9%e5%8c%bb%e5%ad%a6%e7%a0%94","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=214957","title":{"rendered":"Acc. Chem. Res.\u7efc\u8ff0\uff1a\u81ea\u7ec4\u88c5\u8d85\u5206\u5b50\u6811\u5f62\u5206\u5b50\u7528\u4e8e\u751f\u7269\u533b\u5b66\u7814\u7a76"},"content":{"rendered":"<p><strong>\u3010\u80cc\u666f\u4ecb\u7ecd\u3011<\/strong><\/p>\n<p>\u6811\u5f62\u5206\u5b50\u4ee5\u5176\u72ec\u7279\u7684\u5f84\u5411\u5bf9\u79f0\u7ed3\u6784\u4ee5\u53ca\u591a\u4ef7\u534f\u540c\u4f5c\u7528\u800c\u8457\u79f0\uff0c\u5728\u836f\u7269\u9012\u9001\u3001\u8bca\u65ad\u548c\u6cbb\u7597\u7b49\u751f\u7269\u533b\u5b66\u5e94\u7528\u4e0a\u90fd\u5c55\u73b0\u51fa\u4e86\u5de8\u5927\u7684\u6f5c\u529b\u3002\u7136\u800c\uff0c\u8fd9\u7c7b\u5316\u5408\u7269\u7684\u5408\u6210\u548c\u7eaf\u5316\u90fd\u6781\u5176\u56f0\u96be\uff0c\u9650\u5236\u5176\u8fdb\u4e00\u6b65\u7684\u4e34\u5e8a\u8f6c\u5316\u3002\u4e3a\u89e3\u51b3\u8fd9\u4e00\u95ee\u9898\uff0c<strong>\u6cd5\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\uff0c\u827e\u514b\u65af<\/strong><strong>&#8211;<\/strong><strong>\u9a6c\u8d5b\u5927\u5b66\u7684<\/strong><strong>Ling Peng<\/strong>\uff08\u5f6d\u73b2\uff09\u56e2\u961f\u5f00\u521b\u6027\u5730\u5229\u7528\u4e24\u4eb2\u6027\u6811\u5f62\u5206\u5b50\u901a\u8fc7\u81ea\u7ec4\u88c5\u7b56\u7565\u6210\u529f\u6784\u5efa\u4e86\u975e\u5171\u4ef7\u8d85\u5206\u5b50\u6811\u5f62\u5206\u5b50\u3002\u8fd9\u7c7b\u4e24\u4eb2\u6027\u6811\u5f62\u5206\u5b50\u6613\u4e8e\u5408\u6210\u548c\u7eaf\u5316\uff0c\u5176\u6784\u5efa\u7684\u8d85\u5206\u5b50\u6811\u5f62\u5206\u5b50\uff0c\u5728\u7ed3\u6784\u4e0a\u4e0d\u4ec5\u4f9d\u7136\u5177\u6709\u5f84\u5411\u7ed3\u6784\u6a21\u62df\u5171\u4ef7\u6811\u5f62\u5206\u5b50\uff0c\u8fd8\u80fd\u591f\u9012\u9001\u836f\u7269\u548c\u6210\u50cf\u8bd5\u5242\u7528\u4e8e\u751f\u7269\u533b\u5b66\u9886\u57df\u3002<\/p>\n<p><strong>\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n<p>\u8fd1\u671f\uff0c<strong>\u6cd5\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\uff0c\u827e\u514b\u65af<\/strong><strong>&#8211;<\/strong><strong>\u9a6c\u8d5b\u5927\u5b66\u7684<\/strong><strong>Ling Peng<\/strong>\uff08\u5f6d\u73b2\uff0c\u901a\u8baf\u4f5c\u8005\uff09\u8bfe\u9898\u7ec4\u53d1\u8868\u4e86\u7efc\u8ff0\u6587\u7ae0\uff0c\u9610\u8ff0\u4e86\u57fa\u4e8e\u81ea\u7ec4\u88c5\u65b9\u6cd5\u6784\u5efa\u975e\u5171\u4ef7\u8d85\u5206\u5b50\u805a\u9170\u80fa-\u80fa\uff08PAMAM\uff09\u6811\u5f62\u5206\u5b50\u7684\u7b56\u7565\u53ca\u5176\u5728\u751f\u7269\u533b\u5b66\u9886\u57df\u7684\u5e94\u7528\u3002\u8be5\u6587\u7ae0\u9996\u5148\u4ecb\u7ecd\u4e86\u4f20\u7edf\u7684\u6811\u5f62\u5206\u5b50\u53ca\u5176\u5408\u6210\u7b56\u7565\uff0c\u7136\u540e\u4ecb\u7ecd\u4e86\u65b0\u578b\u7684\u975e\u5171\u4ef7\u6811\u5f62\u5206\u5b50\u7684\u81ea\u7ec4\u88c5\u5236\u5907\u65b9\u6cd5\uff0c\u5e76\u603b\u7ed3\u4e86\u8d85\u5206\u5b50\u6811\u5f62\u5206\u5b50\u7528\u4e8e\u9012\u9001\u5316\u5b66\u836f\u7269\u3001\u6838\u9178\u548c\u6210\u50cf\u8bd5\u5242\u7684\u7814\u7a76\uff0c\u62d3\u5c55\u4e86\u6811\u5f62\u5206\u5b50\u5728\u751f\u7269\u533b\u5b66\u9886\u57df\u7684\u5e94\u7528\u524d\u666f\u3002\u8be5\u7efc\u8ff0\u6587\u7ae0\u4ee5\u9898\u4e3a<strong>\u201cSelf-Assembling Supramolecular Dendrimers for Biomedical Applications: Lessons Learned from Poly(amidoamine) Dendrimers\u201d<\/strong>\u53d1\u5e03\u5728\u56fd\u9645\u8457\u540d\u671f\u520a<strong>Acc. Chem. Res.<\/strong>\u4e0a\u3002<\/p>\n<p><strong>\u3010\u56fe\u6587\u89e3\u8bfb\u3011<\/strong><\/p>\n<p><strong>\u56fe\u4e00\u3001\u805a\u9170\u80fa<\/strong><strong>&#8211;<\/strong><strong>\u80fa<\/strong><strong> (PAMAM) <\/strong><strong>\u6811\u5f62\u5206\u5b50\u7684\u5316\u5b66\u7ed3\u6784\u548c\u4f20\u7edf\u6811\u5f62\u5206\u5b50\u7684\u7ed3\u6784\u793a\u610f\u56fe<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-214969\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2020\/12\/1-1.jpeg\" alt=\"\" width=\"600\" height=\"303\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2020\/12\/1-1.jpeg 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2020\/12\/1-1-300x152.jpeg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\uff08A\uff09\u9996\u4e2a\u62a5\u5bfc\u7684\u805a\u9170\u80fa-\u80fa (PAMAM) \u6811\u5f62\u5206\u5b50<strong>1<\/strong>\uff1b<\/p>\n<p>\uff08B\uff09\u6811\u5f62\u5206\u5b50\u7684\u7ed3\u6784\u793a\u610f\u56fe\uff0c\u7531\u4e2d\u5fc3\u6838\u3001\u91cd\u590d\u7684\u5206\u652f\u5355\u5143\u548c\u8868\u9762\u5b98\u80fd\u56e2\u6784\u6210\u3002G0: \u6811\u5f62\u5206\u5b50\u7684\u4e2d\u5fc3\u6838;\u00a0 G1, G2, G3: \u6811\u5f62\u5206\u5b50\u7684\u4ee3\u6570\uff0c\u6bcf\u4e00\u5c42\u79f0\u4e3a\u6811\u5f62\u5206\u5b50\u7684\u4e00\u4ee3.<\/p>\n<p><strong>\u56fe\u4e8c\u3001\u81ea\u7ec4\u88c5\u8d85\u5206\u5b50\u6811\u5f62\u5206\u5b50\u6a21\u62df\u5171\u4ef7\u6811\u5f62\u5206\u5b50\u4ee5\u53ca\u9012\u9001\u836f\u7269\u548c\u6838\u9178\u7684\u793a\u610f\u56fe<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-214968\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2020\/12\/2-1.jpeg\" alt=\"\" width=\"600\" height=\"590\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2020\/12\/2-1.jpeg 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2020\/12\/2-1-300x295.jpeg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\uff08A\uff09\u5c0f\u7684\u4e24\u4eb2\u6027\u6811\u5f62\u5206\u5b50\u81ea\u7ec4\u88c5\u6210\u8d85\u5206\u5b50\u6811\u5f62\u5206\u5b50, \u5e76\u6a21\u62df\u5171\u4ef7\u6811\u5f62\u5206\u5b50\uff1b<\/p>\n<p>\uff08B\uff09\u81ea\u7ec4\u88c5\u8d85\u5206\u5b50\u6811\u5f62\u5206\u5b50\u9012\u9001\u4eb2\/\u758f\u6c34\u836f\u7269\u548c\u6838\u9178\u836f\u7269\u7684\u793a\u610f\u56fe\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u56fe\u4e09\u3001\u6811\u5f62\u5206\u5b50\u7684\u591a\u79cd\u5408\u6210\u65b9\u6cd5<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-214967\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2020\/12\/3-1.jpeg\" alt=\"\" width=\"600\" height=\"715\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2020\/12\/3-1.jpeg 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2020\/12\/3-1-252x300.jpeg 252w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\uff08A\uff09\u53d1\u6563\u6cd5\uff1b<\/p>\n<p>\uff08B\uff09\u6536\u655b\u6cd5\uff1b<\/p>\n<p>\uff08C\uff09\u53d1\u6563\/\u6536\u655b\u5171\u7528\u6cd5\uff1b<\/p>\n<p>\uff08D\uff09\u81ea\u7ec4\u88c5\u6cd5\u6784\u5efa\u975e\u5171\u4ef7\u8d85\u5206\u5b50\u6811\u5f62\u5206\u5b50\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u56fe\u56db\u3001\u5177\u6709\u4e09\u4e59\u9187\u80fa\u5185\u6838\u7684<\/strong><strong>PAMAM<\/strong><strong>\u6811\u5f62\u5206\u5b50<\/strong><strong>2<\/strong><strong>\u7684\u5316\u5b66\u7ed3\u6784<\/strong><\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-214966\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2020\/12\/4-1.jpeg\" alt=\"\" width=\"600\" height=\"579\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2020\/12\/4-1.jpeg 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2020\/12\/4-1-300x290.jpeg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u56fe\u4e94\u3001\u4e24\u4eb2\u6027\u6811\u5f62\u5206\u5b50<\/strong><strong>3-5<\/strong><strong>\u53ca\u5176\u81ea\u7ec4\u88c5\u5f62\u6210\u7684\u8d85\u5206\u5b50\u6811\u5f62\u5206\u5b50\u7528\u4e8e\u5c0f\u5e72\u6270<\/strong><strong>RNA<\/strong><strong>\uff08<\/strong><strong>siRNA<\/strong><strong>\uff09\u9012\u9001<\/strong><\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-214965\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2020\/12\/5-1.jpeg\" alt=\"\" width=\"600\" height=\"521\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2020\/12\/5-1.jpeg 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2020\/12\/5-1-300x261.jpeg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\uff08A\uff09\u4e24\u4eb2\u6027\u6811\u5f62\u5206\u5b50<strong>3<\/strong>&#8211;<strong>5<\/strong>\u7684\u5316\u5b66\u7ed3\u6784\u793a\u610f\u56fe\uff1b<\/p>\n<p>\uff08B\uff09\u4e24\u4eb2\u6027\u6811\u5f62\u5206\u5b50\u81ea\u7ec4\u88c5\u5f62\u6210\u8d85\u5206\u5b50\u6811\u5f62\u5206\u5b50\u7ed3\u5408\u5e76\u9012\u9001siRNA\u7684\u793a\u610f\u56fe\uff1b<\/p>\n<p>\uff08C\uff09\u7531<strong>3<\/strong>\u81ea\u7ec4\u88c5\u5f62\u6210\u7684\u8d85\u5206\u5b50\u6811\u5f62\u5206\u5b50\u7684TEM\u56fe\u50cf\uff1b<\/p>\n<p>\uff08D\uff09\u7531<strong>3<\/strong>\u81ea\u7ec4\u88c5\u7684\u8d85\u5206\u5b50\u6811\u5f62\u5206\u5b50\u9012\u9001siRNA, \u964d\u4f4e\u5c0f\u9f20\u80bf\u7624\u4e2d\u7684Hsp27 mRNA\u6c34\u5e73\uff1b<\/p>\n<p>\uff08E\uff09\u7531<strong>3<\/strong>\u81ea\u7ec4\u88c5\u7684\u8d85\u5206\u5b50\u6811\u5f62\u5206\u5b50\u9012\u9001siRNA, \u964d\u4f4e\u5c0f\u9f20\u80bf\u7624\u4e2d\u7684Hsp27\u86cb\u767d\u7684\u8868\u8fbe\u6c34\u5e73\uff1b<\/p>\n<p>\uff08F\uff09\u7531<strong>3<\/strong>\u548c<strong>4<\/strong>\u81ea\u7ec4\u88c5\u7684\u8d85\u5206\u5b50\u6811\u5f62\u5206\u5b50\u5728HEK293\u7ec6\u80de\u4e2d\u7684\u6bd2\u6027\u8bc4\u4ef7\uff1b<\/p>\n<p>\uff08G\uff09\u7531<strong>4<\/strong>\u81ea\u7ec4\u88c5\u5f62\u6210\u7684\u8d85\u5206\u5b50\u6811\u5f62\u5206\u5b50\u9012\u9001siRNA, \u4f7f\u5f97\u80bf\u7624\u7c7b\u5668\u5b98\u4e2d\u7684\u81f4\u764c\u57fa\u56e0Myc\u7684\u8868\u8fbe\u6c34\u5e73\u964d\u4f4e\uff1b<\/p>\n<p>\uff08H\uff09\u76f8\u6bd4\u4e8e<strong>3<\/strong>, \u7531<strong>5<\/strong>\u81ea\u7ec4\u88c5\u5f62\u6210\u7684\u8d85\u5206\u5b50\u6811\u5f62\u5206\u5b50\u80fd\u591f\u66f4\u52a0\u9ad8\u6548\u5730\u9012\u9001siRNA\u3002<\/p>\n<p><strong>\u56fe\u516d\u3001\u4e24\u4eb2\u6027\u6811\u5f62\u5206\u5b50\u81ea\u7ec4\u88c5\u7684\u6784\u6548\u5173\u7cfb<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-214964\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2020\/12\/6-1.jpeg\" alt=\"\" width=\"600\" height=\"417\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2020\/12\/6-1.jpeg 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2020\/12\/6-1-300x209.jpeg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\uff08A\uff09\u4e24\u4eb2\u6027\u6811\u5f62\u5206\u5b50<strong>3a<\/strong>&#8211;<strong>e<\/strong>\u7684\u5316\u5b66\u7ed3\u6784\u793a\u610f\u56fe\uff1b<\/p>\n<p>\uff08B\uff09\u7531\u4e24\u4eb2\u6027\u6811\u5f62\u5206\u5b50<strong>3c<\/strong>&#8211;<strong>e<\/strong>\u81ea\u7ec4\u88c5\u5f62\u6210\u7684\u8d85\u5206\u5b50\u6811\u5f62\u5206\u5b50\u7684TEM\u56fe\u50cf\u3002<\/p>\n<p><strong>\u56fe\u4e03\u3001\u4e24\u4eb2\u6027\u6811\u5f62\u5206\u5b50<\/strong><strong>8<\/strong><strong>\u53ca\u5176\u8d85\u5206\u5b50\u81ea\u7ec4\u88c5\u4f53\u7528\u4e8e\u5c0f\u5e72\u6270<\/strong><strong>RNA<\/strong><strong>\uff08<\/strong><strong>siRNA<\/strong><strong>\uff09\u7684\u4f20\u9012\u548c\u57fa\u56e0\u6c89\u9ed8<\/strong>\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-214963\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2020\/12\/7-1.jpeg\" alt=\"\" width=\"600\" height=\"358\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2020\/12\/7-1.jpeg 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2020\/12\/7-1-300x179.jpeg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\uff08A\uff09\u6811\u5f62\u5206\u5b50<strong>8<\/strong>\u7684\u5316\u5b66\u7ed3\u6784\u53ca\u5176\u8d85\u5206\u5b50\u81ea\u7ec4\u88c5\u4f53\u4e0esiRNA\u7ed3\u5408\u7684\u793a\u610f\u56fe\uff1b<\/p>\n<p>\uff08B\uff09\u7531<strong>8<\/strong>\u81ea\u7ec4\u88c5\u5f62\u6210\u7684\u8d85\u5206\u5b50\u7684TEM\u56fe\u50cf\uff1b<\/p>\n<p>\uff08C\uff09siRNA\/<strong>8<\/strong>\u590d\u5408\u7269\u7684TEM\u56fe\u50cf\uff1b<\/p>\n<p>\uff08D\uff09\u9012\u9001 Tat\/rev siRNA \u5230\u539f\u4ee3T\u7ec6\u80de\u4e2d, \u964d\u4f4e\u5176Tat\/rev mRNA\u7684\u8868\u8fbe\uff1b<\/p>\n<p>\uff08E\uff09\u9012\u9001NKG2D siRNA\u5230\u539f\u4ee3\u81ea\u7136\u6740\u4f24\u7ec6\u80de\u4e2d, \u964d\u4f4e\u5176NKG2D\u7684\u8868\u8fbe\uff1b<\/p>\n<p>\uff08F\uff09\u9012\u9001JAK1 siRNA \u5230\u539f\u4ee3\u5de8\u566c\u7ec6\u80de\u4e2d, \u964d\u4f4e\u5176JAK1\u86cb\u767d\u8d28\u7684\u8868\u8fbe\u3002<\/p>\n<p><strong>\u56fe\u516b\u3001\u6811\u5f62\u5206\u5b50<\/strong><strong>8<\/strong><strong>\u81ea\u7ec4\u88c5\u7528\u4e8e\u764c\u75c7\u6cbb\u7597\u4e2d\u7684\u9776\u5411<\/strong><strong>siRNA<\/strong><strong>\u9012\u9001\u548c\u57fa\u56e0\u6c89\u9ed8<\/strong><strong>\u3002<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-214962\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2020\/12\/8-1.jpeg\" alt=\"\" width=\"600\" height=\"335\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2020\/12\/8-1.jpeg 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2020\/12\/8-1-300x168.jpeg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\uff08A\uff09\u6811\u5f62\u5206\u5b50<strong>8<\/strong>\u7528\u4e8e\u9776\u5411\u9012\u9001siRNA\u7684\u793a\u610f\u56fe\uff1b<\/p>\n<p>\uff08B\uff09\u9776\u5411\u57fa\u56e0Hsp27\u5728mRNA\u6c34\u5e73\u7684\u8868\u8fbe\uff1b<\/p>\n<p>\uff08C\uff09\u9776\u5411\u9012\u9001siRNA\u80fd\u66f4\u6709\u6548\u6291\u5236\u80bf\u7624\u751f\u957f\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u56fe\u4e5d\u3001\u81ea\u7ec4\u88c5\u8d85\u5206\u5b50\u6811\u5f62\u5206\u5b50\u7528\u4e8e\u6297\u764c\u836f\u7269\u7684\u88c5\u8f7d\u548c\u9012\u9001\u3002<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-214961\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2020\/12\/9-1.jpeg\" alt=\"\" width=\"600\" height=\"342\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2020\/12\/9-1.jpeg 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2020\/12\/9-1-300x171.jpeg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\uff08A\uff09\u4e24\u4eb2\u6027\u6811\u5f62\u5206\u5b50<strong>8<\/strong>\u81ea\u7ec4\u88c5\u5f62\u6210\u8d85\u5206\u5b50\u7eb3\u7c73\u80f6\u675f\u5177\u6709\u5e9e\u5927\u7684\u758f\u6c34\u7a7a\u8154\uff0c\u80fd\u591f\u88c5\u8f7d\u5927\u91cf\u6297\u764c\u836f\u7269\u963f\u9709\u7d20\uff1b<\/p>\n<p>\uff08B\uff09\u8f7d\u836f\u7684\u8d85\u5206\u5b50\u6811\u5f62\u5206\u5b50\u7684TEM\u56fe\u50cf\uff1b<\/p>\n<p>\uff08C\uff09\u8d85\u5206\u5b50\u7eb3\u7c73\u80f6\u675f\u5728\u80bf\u7624\u90e8\u4f4d\u7684\u5bcc\u96c6\u60c5\u51b5\uff1b<\/p>\n<p>\uff08D\uff09\u8f7d\u836f\u7684\u8d85\u5206\u5b50\u7eb3\u7c73\u80f6\u675f\u663e\u8457\u6291\u5236\u80bf\u7624\u7684\u751f\u957f\uff1b<\/p>\n<p>\uff08E\uff09\u8f7d\u836f\u7684\u8d85\u5206\u5b50\u7eb3\u7c73\u80f6\u675f\u53ef\u4ee5\u5ef6\u957f\u8377\u7624\u5c0f\u9f20\u7684\u751f\u5b58\u7387\u3002<\/p>\n<p><strong>\u56fe\u5341\u3001\u6838\u82f7\u7c7b\u836f\u7269\u7684\u4e24\u4eb2\u6027\u6811\u5f62\u5206\u5b50<\/strong><strong>9<\/strong><strong>\u548c<\/strong><strong>10<\/strong><strong>\u7684\u5316\u5b66\u7ed3\u6784<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-214960\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2020\/12\/10-1.jpeg\" alt=\"\" width=\"600\" height=\"354\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2020\/12\/10-1.jpeg 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2020\/12\/10-1-300x177.jpeg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong>\u56fe\u5341\u4e00\u3001\u5e26\u6709\u653e\u5c04\u6027\u6838\u7d20\u7684\u4e24\u4eb2\u6027\u6811\u5f62\u5206\u5b50<\/strong><strong>11<\/strong><strong>\u3001<\/strong><strong>12<\/strong><strong>\u548c<\/strong><strong>13<\/strong><strong>\u81ea\u7ec4\u88c5\u5f62\u6210\u8d85\u5206\u5b50\u7eb3\u7c73\u63a2\u9488\u7528\u4e8e\u80bf\u7624\u7684\u5355\u5149\u5b50\u53d1\u5c04\u8ba1\u7b97\u65ad\u5c42\u626b\u63cf\u6210\u50cf\uff08<\/strong><strong>SPECT<\/strong><strong>\uff09\u548c\u6b63\u7535\u5b50\u53d1\u5c04\u65ad\u5c42\u626b\u63cf\u6210\u50cf\uff08<\/strong><strong>PET<\/strong><strong>\uff09<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-214959\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2020\/12\/11-1.jpeg\" alt=\"\" width=\"600\" height=\"354\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2020\/12\/11-1.jpeg 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2020\/12\/11-1-300x177.jpeg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\uff08A\uff09\u4e24\u4eb2\u6027\u6811\u5f62\u5206\u5b50<strong>11<\/strong><strong>\u3001<\/strong><strong>12<\/strong>\u548c<strong>13<\/strong>\u7684\u5316\u5b66\u7ed3\u6784\u53ca\u5176\u81ea\u7ec4\u88c5\u5f62\u6210\u7684\u8d85\u5206\u5b50\u6811\u5f62\u5206\u5b50\u793a\u610f\u56fe\uff1b<\/p>\n<p>\uff08B\uff09\u4e24\u4eb2\u6027\u6811\u5f62\u5206\u5b50<strong>11<\/strong>\uff08\u5de6\uff09<strong>\u3001<\/strong><strong>12<\/strong>\uff08\u4e2d\uff09\u548c<strong>13<\/strong>\uff08\u53f3\uff09\u5f62\u6210\u7684\u8d85\u5206\u5b50\u7eb3\u7c73\u80f6\u675f\u7684TEM\u56fe\u50cf\uff1b<\/p>\n<p>\uff08C\uff09\u6ce8\u5c04\u7531<strong>11<\/strong>\uff08\u5de6\uff09<strong>\u3001<\/strong><strong>12<\/strong>\uff08\u53f3\uff09\u5f62\u6210\u7684\u8d85\u5206\u5b50\u7eb3\u7c73\u63a2\u9488\u7684\u8377\u7624\u5c0f\u9f20\u7684\u03bcSPECT\/CT\u6210\u50cf\u56fe\uff1b<\/p>\n<p>\uff08D\uff09\u6ce8\u5c04\u7531<strong>13<\/strong>\u5f62\u6210\u7684\u8d85\u5206\u5b50\u7eb3\u7c73\u63a2\u9488\u7684\u5c0f\u9f20PET\u6210\u50cf\u56fe\uff1b<\/p>\n<p>\uff08E\uff09 \u7531<strong>13<\/strong>\u5f62\u6210\u7684\u8d85\u5206\u5b50\u7eb3\u7c73\u63a2\u9488\u5728\u8377\u7624\u5c0f\u9f20\u4e2d\u7684\u80f0\u817a\u764c\u5bcc\u96c6\uff08\u4e0a\uff09\uff0c\u4e34\u5e8a\u9ec4\u91d1\u6807\u51c6\u6210\u50cf\u5242[<sup>18<\/sup>F] FDG\u5728\u80f0\u817a\u764c\u4e2d\u6ca1\u6709\u5bcc\u96c6\uff08\u4e0b\uff09\u3002\u6a59\u8272\u7bad\u5934\u6307\u793a\u80bf\u7624\u4f4d\u7f6e\u3002<\/p>\n<p><strong>\u56fe\u5341\u4e8c\u3001\u5728\u81ea\u7ec4\u88c5\u8d85\u5206\u5b50\u7684\u5185\u8154\u4e2d\u5305\u8f7d\u6210\u50cf\u5242\u7528\u4e8e\u751f\u7269\u6210\u50cf<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-214958\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2020\/12\/12-1.jpeg\" alt=\"\" width=\"600\" height=\"635\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2020\/12\/12-1.jpeg 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2020\/12\/12-1-283x300.jpeg 283w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\uff08A\uff09\u7531\u4e24\u4eb2\u6027\u6811\u5f62\u5206\u5b50<strong>8<\/strong>\u81ea\u7ec4\u88c5\u5f62\u6210\u7684\u8d85\u5206\u5b50\u6811\u5f62\u5206\u5b50\u88c5\u8f7d\u8367\u5149\u67d3\u6599DiR\u7528\u4e8e\u80bf\u7624\u8367\u5149\u6210\u50cf\u7684\u793a\u610f\u56fe\uff1b<\/p>\n<p>\uff08B\uff09\u5c01\u88c5\u5728\u8d85\u5206\u5b50\u6811\u5f62\u5206\u5b50<strong>8<\/strong>\u4e2d\u7684DiR\u5728\u6c34\u4e2d\u7684\u8367\u5149\u53d1\u5c04\u56fe\u8c31\uff1b<\/p>\n<p>\uff08C\uff09DiR\u5728\u6709\u673a\u6eb6\u5242\u7532\u9187\u4e2d\u7684\u8367\u5149\u53d1\u5c04\u56fe\u8c31\uff1b<\/p>\n<p>\uff08D\uff09DiR\/<strong>8<\/strong>\u5f62\u6210\u7684\u8d85\u5206\u5b50\u7eb3\u7c73\u63a2\u9488\u7684TEM\u56fe\u50cf;<\/p>\n<p>\uff08E\uff09\u6ce8\u5c04DiR\/<strong>8<\/strong>\u7eb3\u7c73\u63a2\u9488\u540e\u7684\u8377\u7624\u5c0f\u9f20\u7684\u6d3b\u4f53\u8367\u5149\u6210\u50cf\u56fe\u3002<\/p>\n<p><strong>\u3010\u603b\u7ed3\u3011<\/strong><\/p>\n<p>\u8be5\u6587\u7ae0\u6700\u540e\u603b\u7ed3\u8ba4\u4e3a\u8d85\u5206\u5b50\u6811\u5f62\u5206\u5b50\u7684\u81ea\u7ec4\u88c5\u5408\u6210\u7b56\u7565\u548c\u4e34\u5e8a\u8f6c\u5316\u6781\u5177\u524d\u666f\uff0c\u4f46\u540c\u65f6\u4e5f\u5b58\u5728\u7740\u6311\u6218\u3002\u5c3d\u7ba1\u4e24\u4eb2\u6027\u6811\u5f62\u5206\u5b50\u7684\u5408\u6210\u76f8\u5bf9\u7b80\u5355\u6613\u884c\uff0c\u4f46\u7531\u4e8e\u9a71\u52a8\u81ea\u7ec4\u88c5\u8fc7\u7a0b\u7684\u662f\u8f83\u5f31\u7684\u975e\u5171\u4ef7\u4f5c\u7528\u529b\uff0c\u56e0\u6b64\u5982\u4f55\u589e\u5f3a\u8d85\u5206\u5b50\u6811\u5f62\u5206\u5b50\u7684\u7a33\u5b9a\u6027\u662f\u91cd\u8981\u7684\u6311\u6218\u4e4b\u4e00\u3002\u7279\u522b\u662f\u4f53\u5185\u8840\u6db2\u7684\u7a00\u91ca\u6216\u8005\u4e0e\u751f\u7269\u5927\u5206\u5b50\u7684\u76f8\u4e92\u4f5c\u7528\u53ef\u80fd\u4f1a\u5bfc\u81f4\u5176\u88c5\u8f7d\u7684\u836f\u7269\u6216\u5236\u5242\u63d0\u65e9\u6cc4\u6f0f\u3002\u6b64\u5916\uff0c\u4f5c\u4e3a\u5916\u6765\u7269\u8d28\uff0c\u8d85\u5206\u5b50\u6811\u5f62\u5206\u5b50\u5728\u4f53\u5185\u4e5f\u5bb9\u6613\u88ab\u7f51\u72b6\u5185\u76ae\u7cfb\u7edf\u8bc6\u522b\u5e76\u6e05\u9664\u3002\u8fd9\u4e9b\u95ee\u9898\u90fd\u4e9f\u5f85\u89e3\u51b3\u3002\u6b23\u559c\u7684\u662f\uff0c\u76ee\u524d\u6210\u719f\u7684\u8102\u8d28\u4f53\u53ca\u8d85\u5206\u5b50\u5316\u5b66\u7eb3\u7c73\u836f\u7269\u7684\u7814\u7a76\u53ef\u4ee5\u4e3a\u53d1\u5c55\u81ea\u7ec4\u88c5\u6811\u5f62\u5206\u5b50\u836f\u7269\u63d0\u4f9b\u4e30\u5bcc\u7ecf\u9a8c\uff0c\u6709\u671b\u52a9\u529b\u52a0\u901f\u8d85\u5206\u5b50\u6811\u5f62\u5206\u5b50\u5728\u751f\u7269\u533b\u5b66\u9886\u57df\u7684\u5e94\u7528\u8f6c\u5316\u3002<\/p>\n<p><strong>\u6587\u732e\u94fe\u63a5<\/strong><strong>\uff1a<\/strong><a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.accounts.0c00589\" target=\"_blank\" rel=\"noopener\"><strong>Self-Assembling Supramolecular Dendrimers for Biomedical Applications: Lessons Learned from Poly(amidoamine) Dendrimers<\/strong><\/a>. <em>Acc. Chem. Res.<\/em>, <strong>2020<\/strong>, DOI: 10.1021\/ acs.accounts.0c00589.<\/p>\n<p><strong>\u901a\u8baf\u4f5c\u8005\u7b80\u4ecb\uff1a<\/strong><\/p>\n<p>\u5f6d\u73b2 (PENG Ling) \uff0c\u5973\uff0c1966\u5e74\u51fa\u751f\u4e8e\u4e2d\u56fd\u6e56\u5357\u7701\u8861\u9633\u5e02\u3002\u6cd5\u56fd\u56fd\u5bb6\u79d1\u7814\u4e2d\u5fc3(CNRS)\u4e00\u7ea7\u4e3b\u4efb\u7814\u7a76\u5458\uff0c\u535a\u58eb\u751f\u5bfc\u5e08\u3002\u672c\u79d1\u6bd5\u4e1a\u4e8e\u4e2d\u56fd\u5357\u4eac\u5927\u5b66\u5316\u5b66\u7cfb\uff0c\u5e08\u4ece\u4e8e\u7a0b\u9555\u65f6\u9662\u58eb\u30021993\u5e74\u83b7\u5f97\u745e\u58eb\u8054\u90a6\u82cf\u9ece\u4e16\u7406\u5de5\u5b66\u9662\uff08ETH\uff09\u535a\u58eb\u5b66\u4f4d\uff0c\u5e08\u4ece\u4e8e\u8457\u540d\u7684\u5316\u5b66\u5bb6Albert Eschenmoser\u6559\u6388\u3002\u4e4b\u540e\u5230\u6cd5\u56fd\u65af\u7279\u62c9\u65af\u5821\u5927\u5b66\u836f\u5b66\u9662\u4ece\u4e8b\u535a\u58eb\u540e\u7814\u7a76\u30021997\u5e74\u6210\u4e3a\u6cd5\u56fd\u56fd\u5bb6\u79d1\u7814\u4e2d\u5fc3\u7ec8\u8eab\u7814\u7a76\u5458\uff0c2008\u5e74\u664b\u5347\u4e3b\u4efb\u7814\u7a76\u5458\uff0c2015\u5e74\u664b\u5347\u4e00\u7ea7\u4e3b\u4efb\u7814\u7a76\u5458\u3002\u73b0\u662f\u6cd5\u56fd\u9a6c\u8d5b\u7eb3\u7c73\u79d1\u5b66\u8de8\u5b66\u79d1\u7814\u7a76\u4e2d\u5fc3\u8bfe\u9898\u8d1f\u8d23\u4eba\u3002<\/p>\n<p>\u5f6d\u73b2\u535a\u58eb\u8fd1\u5e74\u6765\u4e3b\u8981\u81f4\u529b\u4e8e\u7814\u7a76\u591a\u529f\u80fd\u667a\u80fd\u7eb3\u7c73\u6750\u6599\u5728\u836f\u7269\u9012\u9001\u4ee5\u53ca\u751f\u7269\u533b\u5b66\u5f71\u50cf\u65b9\u9762\u7684\u5e94\u7528\uff0c\u6210\u529f\u5f00\u53d1\u51fa\u81ea\u7ec4\u88c5\u6811\u72b6\u5927\u5206\u5b50\u4eff\u751f\u7eb3\u7c73\u6750\u6599\uff0c\u4e3a\u751f\u7269\u533b\u7528\u6750\u6599\u9886\u57df\u5f00\u8f9f\u4e86\u65b0\u65b9\u5411\u3002\u76ee\u524d\u5df2\u5728\u5305\u62ec\u300aPNAS\u300b\u3001\u300aAngewandte Chemie International Edition\u300b\u3001\u300aJ Am Chem Soc\u300b\u3001 \u300aNature Communications\u300b\u3001\u300aNature Protocols\u300b\u7b49\u56fd\u9645\u4e00\u6d41\u4e13\u4e1a\u671f\u520a\u4e0a\u53d1\u8868100\u591a\u7bc7SCI\u79d1\u5b66\u8bba\u6587\u3002\u8fc4\u4eca\u4e3a\u6b62\uff0c\u5f6d\u73b2\u535a\u58eb\u5148\u540e\u4e3b\u6301\u4e86\u6cd5\u56fd\u548c\u6b27\u76df\u591a\u9879\u7eb3\u7c73\u751f\u7269\u533b\u836f\u79d1\u7814\u9879\u76ee\u3002\u9274\u4e8e\u5f6d\u73b2\u535a\u58eb\u5728\u5316\u5b66\u751f\u7269\u5b66\u7814\u7a76\u9886\u57df\u53bb\u7684\u7684\u7a81\u51fa\u6210\u679c\uff0c\u83b7\u98812017\u5e74\u6cd5\u56fd\u6cd5\u5170\u897f\u79d1\u5b66\u9662\u201c\u6602\u91cc\u00d7\u62c9\u8d1d\u535a\u58eb\u592b\u5987\u5956\u201d\u30022020\u5e74\u5f6d\u73b2\u535a\u58eb\u6210\u4e3a\u6cd5\u56fd\u5316\u5b66\u4f1a\u7ec8\u751f\u6770\u51fa\u4f1a\u5458.<\/p>\n<p>\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1\uff1atougao@cailiaoren.com.<\/p>\n<p>\u6295\u7a3f\u4ee5\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1acailiaokefu.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u80cc\u666f\u4ecb\u7ecd\u3011 \u6811\u5f62\u5206\u5b50\u4ee5\u5176\u72ec\u7279\u7684\u5f84\u5411\u5bf9\u79f0\u7ed3\u6784\u4ee5\u53ca\u591a\u4ef7\u534f\u540c\u4f5c\u7528\u800c\u8457\u79f0\uff0c\u5728\u836f\u7269\u9012\u9001\u3001\u8bca\u65ad\u548c\u6cbb\u7597\u7b49\u751f\u7269\u533b\u5b66\u5e94\u7528\u4e0a\u90fd\u5c55\u73b0\u51fa\u4e86\u5de8\u5927\u7684\u6f5c\u529b\u3002\u7136\u800c\uff0c\u8fd9\u7c7b\u5316\u5408\u7269\u7684\u5408\u6210\u548c\u7eaf\u5316\u90fd\u6781&#8230;<\/p>\n","protected":false},"author":1076,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215],"tags":[],"class_list":["post-214957","post","type-post","status-publish","format-standard","hentry","category-jiedu"],"_links":{"self":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/214957"}],"collection":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/users\/1076"}],"replies":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=214957"}],"version-history":[{"count":2,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/214957\/revisions"}],"predecessor-version":[{"id":214971,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/214957\/revisions\/214971"}],"wp:attachment":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=214957"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=214957"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=214957"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}